ID HSPB7_HUMAN Reviewed; 170 AA. AC Q9UBY9; B3KQ37; C9K0Y0; Q9NU17; DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 28-JAN-2026, entry version 178. DE RecName: Full=Heat shock protein beta-7; DE Short=HspB7; DE AltName: Full=Cardiovascular heat shock protein; DE Short=cvHsp; GN Name=HSPB7; Synonyms=CVHSP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). RC TISSUE=Heart; RX PubMed=10593960; DOI=10.1074/jbc.274.51.36592; RA Krief S., Faivre J.-F., Robert P., Le Douarin B., Brument-Larignon N., RA Lefrere I., Bouzyk M.M., Anderson K.M., Greller L.D., Tobin F.L., RA Souchet M., Bril A.; RT "Identification and characterization of cvHsp. A novel human small stress RT protein selectively expressed in cardiovascular and insulin-sensitive RT tissues."; RL J. Biol. Chem. 274:36592-36600(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Salivary gland; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP SUBCELLULAR LOCATION. RX PubMed=19464326; DOI=10.1016/j.bbamcr.2009.05.005; RA Vos M.J., Kanon B., Kampinga H.H.; RT "HSPB7 is a SC35 speckle resident small heat shock protein."; RL Biochim. Biophys. Acta 1793:1343-1353(2009). CC -!- SUBUNIT: Interacts with C-terminal domain of actin-binding protein 280. CC -!- INTERACTION: CC Q9UBY9; O95817: BAG3; NbExp=3; IntAct=EBI-739361, EBI-747185; CC Q9UBY9; Q8WYQ4-2: C22orf15; NbExp=6; IntAct=EBI-739361, EBI-12030460; CC Q9UBY9; Q8TAP6: CEP76; NbExp=6; IntAct=EBI-739361, EBI-742887; CC Q9UBY9; Q96D03: DDIT4L; NbExp=5; IntAct=EBI-739361, EBI-742054; CC Q9UBY9; P63172: DYNLT1; NbExp=3; IntAct=EBI-739361, EBI-1176455; CC Q9UBY9; P21333-2: FLNA; NbExp=10; IntAct=EBI-739361, EBI-9641086; CC Q9UBY9; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-739361, EBI-11978177; CC Q9UBY9; Q9UJY1: HSPB8; NbExp=11; IntAct=EBI-739361, EBI-739074; CC Q9UBY9; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-739361, EBI-747204; CC Q9UBY9; Q9NR12: PDLIM7; NbExp=3; IntAct=EBI-739361, EBI-350517; CC Q9UBY9; P78356-2: PIP4K2B; NbExp=3; IntAct=EBI-739361, EBI-11532361; CC Q9UBY9; Q9H8W4: PLEKHF2; NbExp=6; IntAct=EBI-739361, EBI-742388; CC Q9UBY9; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-739361, EBI-3957793; CC Q9UBY9; Q04864: REL; NbExp=3; IntAct=EBI-739361, EBI-307352; CC Q9UBY9; Q04864-2: REL; NbExp=3; IntAct=EBI-739361, EBI-10829018; CC Q9UBY9; Q15427: SF3B4; NbExp=3; IntAct=EBI-739361, EBI-348469; CC Q9UBY9; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-739361, EBI-6872807; CC Q9UBY9; P15884: TCF4; NbExp=3; IntAct=EBI-739361, EBI-533224; CC Q9UBY9; P15884-3: TCF4; NbExp=3; IntAct=EBI-739361, EBI-13636688; CC Q9UBY9; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-739361, EBI-11139477; CC Q9UBY9; P36406: TRIM23; NbExp=3; IntAct=EBI-739361, EBI-740098; CC Q9UBY9; Q04323-2: UBXN1; NbExp=3; IntAct=EBI-739361, EBI-11530712; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus CC {ECO:0000269|PubMed:19464326}. Nucleus, Cajal body CC {ECO:0000269|PubMed:19464326}. Note=Resides in sub-nuclear structures CC known as SC35 speckles or nuclear splicing speckles. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9UBY9-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9UBY9-2; Sequence=VSP_002424; CC Name=3; CC IsoId=Q9UBY9-3; Sequence=VSP_002425, VSP_002426; CC -!- TISSUE SPECIFICITY: Isoform 1 is highly expressed in adult and fetal CC heart, skeletal muscle, and at a much lower levels in adipose tissue CC and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 CC are poorly detected in heart. CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA CC decay. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family. CC {ECO:0000255|PROSITE-ProRule:PRU00285}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ243191; CAB63258.1; -; mRNA. DR EMBL; AF155908; AAF20022.1; -; mRNA. DR EMBL; AK057295; BAG51899.1; -; mRNA. DR EMBL; CR749298; CAH18153.1; -; mRNA. DR EMBL; AL096775; CAB86671.1; -; Genomic_DNA. DR EMBL; AL355994; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC006319; AAH06319.1; -; mRNA. DR CCDS; CCDS30611.1; -. [Q9UBY9-1] DR CCDS; CCDS85932.1; -. [Q9UBY9-2] DR RefSeq; NP_001336618.1; NM_001349689.2. [Q9UBY9-2] DR RefSeq; NP_055239.1; NM_014424.5. [Q9UBY9-1] DR PDB; 8PA0; X-ray; 2.85 A; B=73-157. DR PDB; 8RHA; X-ray; 2.18 A; A/B/C=73-157. DR PDBsum; 8PA0; -. DR PDBsum; 8RHA; -. DR AlphaFoldDB; Q9UBY9; -. DR SMR; Q9UBY9; -. DR BioGRID; 118020; 23. DR FunCoup; Q9UBY9; 533. DR IntAct; Q9UBY9; 24. DR STRING; 9606.ENSP00000364870; -. DR iPTMnet; Q9UBY9; -. DR PhosphoSitePlus; Q9UBY9; -. DR BioMuta; HSPB7; -. DR jPOST; Q9UBY9; -. DR MassIVE; Q9UBY9; -. DR PaxDb; 9606-ENSP00000310111; -. DR PeptideAtlas; Q9UBY9; -. DR ProteomicsDB; 84101; -. [Q9UBY9-1] DR ProteomicsDB; 84102; -. [Q9UBY9-2] DR ProteomicsDB; 84103; -. [Q9UBY9-3] DR Antibodypedia; 29049; 264 antibodies from 30 providers. DR DNASU; 27129; -. DR Ensembl; ENST00000311890.14; ENSP00000310111.9; ENSG00000173641.19. [Q9UBY9-1] DR Ensembl; ENST00000487046.1; ENSP00000419477.1; ENSG00000173641.19. [Q9UBY9-2] DR GeneID; 27129; -. DR KEGG; hsa:27129; -. DR MANE-Select; ENST00000311890.14; ENSP00000310111.9; NM_014424.5; NP_055239.1. DR UCSC; uc001axo.2; human. [Q9UBY9-1] DR AGR; HGNC:5249; -. DR ClinPGx; PA29514; -. DR CTD; 27129; -. DR DisGeNET; 27129; -. DR GeneCards; HSPB7; -. DR HGNC; HGNC:5249; HSPB7. DR HPA; ENSG00000173641; Group enriched (heart muscle, skeletal muscle, tongue). DR MIM; 610692; gene. DR OpenTargets; ENSG00000173641; -. DR VEuPathDB; HostDB:ENSG00000173641; -. DR eggNOG; KOG3591; Eukaryota. DR GeneTree; ENSGT00390000010674; -. DR HOGENOM; CLU_124226_0_0_1; -. DR InParanoid; Q9UBY9; -. DR OMA; CNPYMEK; -. DR OrthoDB; 9925191at2759; -. DR PAN-GO; Q9UBY9; 2 GO annotations based on evolutionary models. DR PhylomeDB; Q9UBY9; -. DR PathwayCommons; Q9UBY9; -. DR SignaLink; Q9UBY9; -. DR Agora; ENSG00000173641; -. DR BioGRID-ORCS; 27129; 16 hits in 1141 CRISPR screens. DR CD-CODE; 6F24707C; Cajal body. DR ChiTaRS; HSPB7; human. DR GenomeRNAi; 27129; -. DR Pharos; Q9UBY9; Tbio. DR PRO; PR:Q9UBY9; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q9UBY9; protein. DR Bgee; ENSG00000173641; Expressed in left ventricle myocardium and 135 other cell types or tissues. DR ExpressionAtlas; Q9UBY9; baseline and differential. DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl. DR GO; GO:0016235; C:aggresome; IDA:HPA. DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0031005; F:filamin binding; IEA:Ensembl. DR GO; GO:0007507; P:heart development; IEA:InterPro. DR GO; GO:0008016; P:regulation of heart contraction; TAS:ProtInc. DR GO; GO:0006986; P:response to unfolded protein; TAS:ProtInc. DR CDD; cd06479; ACD_HspB7_like; 1. DR FunFam; 2.60.40.790:FF:000020; heat shock protein beta-7 isoform X1; 1. DR Gene3D; 2.60.40.790; -; 1. DR InterPro; IPR002068; A-crystallin/Hsp20_dom. DR InterPro; IPR037885; ACD_HspB7. DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal. DR InterPro; IPR008978; HSP20-like_chaperone. DR PANTHER; PTHR46907:SF2; HEAT SHOCK PROTEIN BETA-7; 1. DR PANTHER; PTHR46907; HEAT SHOCK PROTEIN BETA-7-RELATED; 1. DR Pfam; PF00011; HSP20; 1. DR PRINTS; PR00299; ACRYSTALLIN. DR SUPFAM; SSF49764; HSP20-like chaperones; 1. DR PROSITE; PS01031; SHSP; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Chaperone; Cytoplasm; Nucleus; KW Proteomics identification; Reference proteome; Stress response. FT CHAIN 1..170 FT /note="Heat shock protein beta-7" FT /id="PRO_0000125941" FT DOMAIN 62..170 FT /note="sHSP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285" FT REGION 1..71 FT /note="Required for localization to SC35 splicing speckles" FT REGION 1..39 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 16..31 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 67 FT /note="A -> AAHPTA (in isoform 2)" FT /evidence="ECO:0000303|PubMed:10593960, FT ECO:0000303|PubMed:17974005" FT /id="VSP_002424" FT VAR_SEQ 68 FT /note="R -> K (in isoform 3)" FT /evidence="ECO:0000303|PubMed:10593960" FT /id="VSP_002425" FT VAR_SEQ 69..170 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:10593960" FT /id="VSP_002426" FT STRAND 81..86 FT /evidence="ECO:0007829|PDB:8RHA" FT HELIX 93..95 FT /evidence="ECO:0007829|PDB:8RHA" FT STRAND 96..101 FT /evidence="ECO:0007829|PDB:8RHA" FT STRAND 104..112 FT /evidence="ECO:0007829|PDB:8RHA" FT STRAND 118..127 FT /evidence="ECO:0007829|PDB:8RHA" FT HELIX 134..136 FT /evidence="ECO:0007829|PDB:8RHA" FT STRAND 138..141 FT /evidence="ECO:0007829|PDB:8RHA" FT STRAND 147..153 FT /evidence="ECO:0007829|PDB:8RHA" SQ SEQUENCE 170 AA; 18611 MW; 0A6F47931AE67B3E CRC64; MSHRTSSTFR AERSFHSSSS SSSSSTSSSA SRALPAQDPP MEKALSMFSD DFGSFMRPHS EPLAFPARPG GAGNIKTLGD AYEFAVDVRD FSPEDIIVTT SNNHIEVRAE KLAADGTVMN TFAHKCQLPE DVDPTSVTSA LREDGSLTIR ARRHPHTEHV QQTFRTEIKI //