ID   HSPB9_HUMAN             Reviewed;         159 AA.
AC   Q9BQS6; B3KSG6; Q52LB4;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   28-JAN-2026, entry version 148.
DE   RecName: Full=Heat shock protein beta-9;
DE            Short=HspB9;
DE   AltName: Full=Cancer/testis antigen 51;
DE            Short=CT51;
DE   AltName: Full=Heat shock protein family B member 9;
GN   Name=HSPB9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=11470154; DOI=10.1016/s0167-4781(01)00237-8;
RA   Kappe G., Verschuure P., Philipsen R.L.A., Staalduinen A.A.,
RA   Van de Boogaart P., Boelens W.C., de Jong W.W.;
RT   "Characterization of two novel human small heat shock proteins: protein
RT   kinase-related HspB8 and testis-specific HspB9.";
RL   Biochim. Biophys. Acta 1520:1-6(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19464326; DOI=10.1016/j.bbamcr.2009.05.005;
RA   Vos M.J., Kanon B., Kampinga H.H.;
RT   "HSPB7 is a SC35 speckle resident small heat shock protein.";
RL   Biochim. Biophys. Acta 1793:1343-1353(2009).
CC   -!- INTERACTION:
CC       Q9BQS6; P63172: DYNLT1; NbExp=5; IntAct=EBI-1176448, EBI-1176455;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus
CC       {ECO:0000269|PubMed:19464326}. Note=Translocates to nuclear foci during
CC       heat shock.
CC   -!- TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:11470154}.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; AJ302068; CAC35727.1; -; Genomic_DNA.
DR   EMBL; AK093488; BAG52728.1; -; mRNA.
DR   EMBL; CH471152; EAW60804.1; -; Genomic_DNA.
DR   EMBL; BC093991; AAH93991.1; -; mRNA.
DR   EMBL; BC093993; AAH93993.1; -; mRNA.
DR   CCDS; CCDS11418.1; -.
DR   RefSeq; NP_149971.1; NM_033194.3.
DR   AlphaFoldDB; Q9BQS6; -.
DR   SMR; Q9BQS6; -.
DR   BioGRID; 125108; 25.
DR   FunCoup; Q9BQS6; 893.
DR   IntAct; Q9BQS6; 14.
DR   STRING; 9606.ENSP00000458018; -.
DR   PhosphoSitePlus; Q9BQS6; -.
DR   BioMuta; HSPB9; -.
DR   DMDM; 46576635; -.
DR   MassIVE; Q9BQS6; -.
DR   PaxDb; 9606-ENSP00000458018; -.
DR   Antibodypedia; 59368; 93 antibodies from 22 providers.
DR   DNASU; 94086; -.
DR   Ensembl; ENST00000565659.2; ENSP00000458018.1; ENSG00000260325.2.
DR   GeneID; 94086; -.
DR   KEGG; hsa:94086; -.
DR   MANE-Select; ENST00000565659.2; ENSP00000458018.1; NM_033194.3; NP_149971.1.
DR   UCSC; uc002hyy.3; human.
DR   AGR; HGNC:30589; -.
DR   ClinPGx; PA134875756; -.
DR   CTD; 94086; -.
DR   DisGeNET; 94086; -.
DR   GeneCards; HSPB9; -.
DR   HGNC; HGNC:30589; HSPB9.
DR   HPA; ENSG00000260325; Tissue enhanced (testis).
DR   MIM; 608344; gene.
DR   OpenTargets; ENSG00000260325; -.
DR   VEuPathDB; HostDB:ENSG00000260325; -.
DR   eggNOG; KOG3591; Eukaryota.
DR   GeneTree; ENSGT00510000049735; -.
DR   HOGENOM; CLU_1585932_0_0_1; -.
DR   InParanoid; Q9BQS6; -.
DR   OMA; TAMTCCL; -.
DR   OrthoDB; 8946669at2759; -.
DR   PAN-GO; Q9BQS6; 2 GO annotations based on evolutionary models.
DR   PhylomeDB; Q9BQS6; -.
DR   PathwayCommons; Q9BQS6; -.
DR   SignaLink; Q9BQS6; -.
DR   BioGRID-ORCS; 94086; 14 hits in 1140 CRISPR screens.
DR   GenomeRNAi; 94086; -.
DR   Pharos; Q9BQS6; Tbio.
DR   PRO; PR:Q9BQS6; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9BQS6; protein.
DR   Bgee; ENSG00000260325; Expressed in left testis and 99 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   CDD; cd06481; ACD_HspB9_like; 1.
DR   FunFam; 2.60.40.790:FF:000063; Heat shock protein beta-9; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR042940; HSPB9.
DR   PANTHER; PTHR47896; HEAT SHOCK PROTEIN BETA-9; 1.
DR   PANTHER; PTHR47896:SF1; HEAT SHOCK PROTEIN BETA-9; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Proteomics identification; Reference proteome;
KW   Stress response.
FT   CHAIN           1..159
FT                   /note="Heat shock protein beta-9"
FT                   /id="PRO_0000125950"
FT   DOMAIN          36..147
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   VARIANT         2
FT                   /note="Q -> P (in dbSNP:rs1122326)"
FT                   /id="VAR_022054"
SQ   SEQUENCE   159 AA;  17486 MW;  F28E40D0512C4997 CRC64;
     MQRVGNTFSN ESRVASRCPS VGLAERNRVA TMPVRLLRDS PAAQEDNDHA RDGFQMKLDA
     HGFAPEELVV QVDGQWLMVT GQQQLDVRDP ERVSYRMSQK VHRKMLPSNL SPTAMTCCLT
     PSGQLWVRGQ CVALALPEAQ TGPSPRLGSL GSKASNLTR
//