IGFBP3

UniProt ID: P17936
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for IGFBP3

Existing Annotations Review

GO Term Evidence Action Reason
GO:0031994 insulin-like growth factor I binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031995 insulin-like growth factor II binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001968 fibronectin binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005520 insulin-like growth factor binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006915 apoptotic process
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0014912 negative regulation of smooth muscle cell migration
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019838 growth factor binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031994 insulin-like growth factor I binding
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042567 insulin-like growth factor ternary complex
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048662 negative regulation of smooth muscle cell proliferation
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20353938
Identification of a novel cell death receptor mediating IGFB... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20353938
2010 Mar 30. Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer.
GO:0005515 protein binding
IPI
PMID:23178489
The role of insulin-like growth factor binding protein-3 in ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23178489
The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents.
GO:0005515 protein binding
IPI
PMID:30184438
Interaction of Insulin-Like Growth Factor-Binding Protein 3 ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:30184438
Epub 2018 Sep 17. Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.
GO:0005515 protein binding
IPI
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
GO:0001649 osteoblast differentiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001968 fibronectin binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-381466 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26216267
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:26216267
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
GO:0005788 endoplasmic reticulum lumen
TAS
Reactome:R-HSA-8952289 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042567 insulin-like growth factor ternary complex
IDA
PMID:9497324
Insulin-like growth factor (IGF)-binding protein 5 forms an ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9497324
Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.
GO:0005576 extracellular region
TAS
Reactome:R-HSA-381435 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-381446 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-381461 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-381496 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-381500 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-6800035 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-6800044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008285 negative regulation of cell population proliferation
IGI
PMID:19258508
NKX3.1 activates expression of insulin-like growth factor bi... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19258508
Epub 2009 Mar 3. NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation.
GO:0014912 negative regulation of smooth muscle cell migration
IDA
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
GO:0016942 insulin-like growth factor binding protein complex
IC
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
GO:0031994 insulin-like growth factor I binding
IPI
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
GO:0048662 negative regulation of smooth muscle cell proliferation
IDA
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
GO:0005615 extracellular space
IDA
PMID:17119061
Ethnic disparity in the relationship between obesity and pla... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17119061
Ethnic disparity in the relationship between obesity and plasma insulin-like growth factors: the multiethnic cohort.
GO:0001933 negative regulation of protein phosphorylation
IDA
PMID:17591901
The requirement of pax6 for postnatal eye development: evide... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17591901
The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras.
GO:0005634 nucleus
IDA
PMID:17434920
Contribution of the orphan nuclear receptor Nur77 to the apo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17434920
Apr 13. Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.
GO:0006468 protein phosphorylation
IDA
PMID:17434920
Contribution of the orphan nuclear receptor Nur77 to the apo... 		MODIFY
Summary: OVER-ANNOTATION: IGFBP3 is an IGF-binding protein that modulates IGF signaling. It has NO kinase activity. IGFBP3 affects phosphorylation indirectly by regulating IGF availability and signaling, but doesn't catalyze phosphorylation itself.
Supporting Evidence:
PMID:17434920
Apr 13. Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.
GO:0005515 protein binding
IPI
PMID:14561895
Interaction between the Alzheimer's survival peptide humanin... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14561895
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.
GO:0005515 protein binding
IPI
PMID:9388210
Inhibition of insulin receptor activation by insulin-like gr... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9388210
Inhibition of insulin receptor activation by insulin-like growth factor binding proteins.
GO:0005520 insulin-like growth factor binding
NAS
PMID:12599210
Role of insulin-like growth factor binding protein-3 (IGFBP-... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12599210
Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts.
GO:0008160 protein tyrosine phosphatase activator activity
IDA
PMID:11940579
Insulin-like growth factor-binding protein-3 activates a pho... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11940579
2002 Apr 8. Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase.
GO:0009968 negative regulation of signal transduction
NAS
PMID:11940579
Insulin-like growth factor-binding protein-3 activates a pho... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11940579
2002 Apr 8. Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase.
GO:0043065 positive regulation of apoptotic process
IMP
PMID:11971816
Insulin-like growth factor binding protein-3 mediates tumor ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11971816
Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation.
GO:0045663 positive regulation of myoblast differentiation
IDA
PMID:12599210
Role of insulin-like growth factor binding protein-3 (IGFBP-... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12599210
Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts.
GO:0046872 metal ion binding
NAS
PMID:14576163
Insulin-like growth factor-independent effects mediated by a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14576163
Oct 22. Insulin-like growth factor-independent effects mediated by a C-terminal metal-binding domain of insulin-like growth factor binding protein-3.
GO:0005576 extracellular region
NAS
PMID:14718574
The human plasma proteome: a nonredundant list developed by ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14718574
Epub 2004 Jan 12. The human plasma proteome: a nonredundant list developed by combination of four separate sources.

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
PMID:11940579
Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulin-like growth factor signaling pathway.
PMID:11971816
Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation.
PMID:12599210
Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts.
PMID:14561895
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.
PMID:14576163
Insulin-like growth factor-independent effects mediated by a C-terminal metal-binding domain of insulin-like growth factor binding protein-3.
PMID:14718574
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
PMID:17119061
Ethnic disparity in the relationship between obesity and plasma insulin-like growth factors: the multiethnic cohort.
PMID:17434920
Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.
PMID:17591901
The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras.
PMID:19258508
NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation.
PMID:20353938
Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer.
PMID:23178489
The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents.
PMID:26216267
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
PMID:30184438
Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:9388210
Inhibition of insulin receptor activation by insulin-like growth factor binding proteins.
PMID:9497324
Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.
Reactome:R-HSA-381435
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS
Reactome:R-HSA-381446
Thrombin proteolyzes IGF:IGFBP3:ALS
Reactome:R-HSA-381461
Plasmin proteolyzes IGF:IGFBP-3:ALS
Reactome:R-HSA-381466
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS
Reactome:R-HSA-381496
Formation of the IGF:IGFBP3:ALS complex
Reactome:R-HSA-381500
Cathepsin G proteolyzes IGF:IGFBP3:ALS
Reactome:R-HSA-6800035
IGFBP3 binds TMEM219
Reactome:R-HSA-6800044
TP53 stimulates IGFBP3 expression
Reactome:R-HSA-8952289
FAM20C phosphorylates FAM20C substrates

📄 View Raw YAML

 
id: P17936
gene_symbol: IGFBP3
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for IGFBP3'
existing_annotations:
  - term:
      id: GO:0031994
      label: insulin-like growth factor I binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031995
      label: insulin-like growth factor II binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001968
      label: fibronectin binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043567
      label: regulation of insulin-like growth factor receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005520
      label: insulin-like growth factor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006915
      label: apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014912
      label: negative regulation of smooth muscle cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019838
      label: growth factor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031994
      label: insulin-like growth factor I binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042567
      label: insulin-like growth factor ternary complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048662
      label: negative regulation of smooth muscle cell proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20353938
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20353938
          supporting_text: 2010 Mar 30. Identification of a novel cell death 
            receptor mediating IGFBP-3-induced anti-tumor effects in breast and 
            prostate cancer.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23178489
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23178489
          supporting_text: The role of insulin-like growth factor binding 
            protein-3 in the breast cancer cell response to DNA-damaging agents.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:30184438
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30184438
          supporting_text: Epub 2018 Sep 17. Interaction of Insulin-Like Growth 
            Factor-Binding Protein 3 With Hyaluronan and Its Regulation by 
            Humanin and CD44.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32814053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32814053
          supporting_text: Interactome Mapping Provides a Network of 
            Neurodegenerative Disease Proteins and Uncovers Widespread Protein 
            Aggregation in Affected Brains.
  - term:
      id: GO:0001649
      label: osteoblast differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001968
      label: fibronectin binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-381466
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26216267
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26216267
          supporting_text: Humanin Peptide Binds to Insulin-Like Growth 
            Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with
            Importin-β.
  - term:
      id: GO:0005788
      label: endoplasmic reticulum lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952289
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042567
      label: insulin-like growth factor ternary complex
    evidence_type: IDA
    original_reference_id: PMID:9497324
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9497324
          supporting_text: Insulin-like growth factor (IGF)-binding protein 5 
            forms an alternative ternary complex with IGFs and the acid-labile 
            subunit.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-381435
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-381446
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-381461
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-381496
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-381500
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6800035
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6800044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008285
      label: negative regulation of cell population proliferation
    evidence_type: IGI
    original_reference_id: PMID:19258508
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19258508
          supporting_text: Epub 2009 Mar 3. NKX3.1 activates expression of 
            insulin-like growth factor binding protein-3 to mediate insulin-like
            growth factor-I signaling and cell proliferation.
  - term:
      id: GO:0014912
      label: negative regulation of smooth muscle cell migration
    evidence_type: IDA
    original_reference_id: PMID:10766744
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10766744
          supporting_text: Substitutions for hydrophobic amino acids in the 
            N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding 
            and alter their biologic actions.
  - term:
      id: GO:0016942
      label: insulin-like growth factor binding protein complex
    evidence_type: IC
    original_reference_id: PMID:10766744
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10766744
          supporting_text: Substitutions for hydrophobic amino acids in the 
            N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding 
            and alter their biologic actions.
  - term:
      id: GO:0031994
      label: insulin-like growth factor I binding
    evidence_type: IPI
    original_reference_id: PMID:10766744
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10766744
          supporting_text: Substitutions for hydrophobic amino acids in the 
            N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding 
            and alter their biologic actions.
  - term:
      id: GO:0048662
      label: negative regulation of smooth muscle cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:10766744
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10766744
          supporting_text: Substitutions for hydrophobic amino acids in the 
            N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding 
            and alter their biologic actions.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:17119061
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17119061
          supporting_text: 'Ethnic disparity in the relationship between obesity and
            plasma insulin-like growth factors: the multiethnic cohort.'
  - term:
      id: GO:0001933
      label: negative regulation of protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:17591901
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17591901
          supporting_text: 'The requirement of pax6 for postnatal eye development:
            evidence from experimental mouse chimeras.'
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:17434920
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17434920
          supporting_text: Apr 13. Contribution of the orphan nuclear receptor 
            Nur77 to the apoptotic action of IGFBP-3.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:17434920
    review:
      summary: >-
        OVER-ANNOTATION: IGFBP3 is an IGF-binding protein that modulates IGF signaling.
        It has NO kinase activity. IGFBP3 affects phosphorylation indirectly by regulating
        IGF availability and signaling, but doesn't catalyze phosphorylation itself.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:17434920
          supporting_text: Apr 13. Contribution of the orphan nuclear receptor 
            Nur77 to the apoptotic action of IGFBP-3.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:14561895
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14561895
          supporting_text: Interaction between the Alzheimer's survival peptide 
            humanin and insulin-like growth factor-binding protein 3 regulates 
            cell survival and apoptosis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9388210
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9388210
          supporting_text: Inhibition of insulin receptor activation by 
            insulin-like growth factor binding proteins.
  - term:
      id: GO:0005520
      label: insulin-like growth factor binding
    evidence_type: NAS
    original_reference_id: PMID:12599210
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12599210
          supporting_text: Role of insulin-like growth factor binding protein-3 
            (IGFBP-3) in the differentiation of primary human adult skeletal 
            myoblasts.
  - term:
      id: GO:0008160
      label: protein tyrosine phosphatase activator activity
    evidence_type: IDA
    original_reference_id: PMID:11940579
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11940579
          supporting_text: 2002 Apr 8. Insulin-like growth factor-binding 
            protein-3 activates a phosphotyrosine phosphatase.
  - term:
      id: GO:0009968
      label: negative regulation of signal transduction
    evidence_type: NAS
    original_reference_id: PMID:11940579
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11940579
          supporting_text: 2002 Apr 8. Insulin-like growth factor-binding 
            protein-3 activates a phosphotyrosine phosphatase.
  - term:
      id: GO:0043065
      label: positive regulation of apoptotic process
    evidence_type: IMP
    original_reference_id: PMID:11971816
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11971816
          supporting_text: 'Insulin-like growth factor binding protein-3 mediates
            tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation.'
  - term:
      id: GO:0045663
      label: positive regulation of myoblast differentiation
    evidence_type: IDA
    original_reference_id: PMID:12599210
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12599210
          supporting_text: Role of insulin-like growth factor binding protein-3 
            (IGFBP-3) in the differentiation of primary human adult skeletal 
            myoblasts.
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: NAS
    original_reference_id: PMID:14576163
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14576163
          supporting_text: Oct 22. Insulin-like growth factor-independent 
            effects mediated by a C-terminal metal-binding domain of 
            insulin-like growth factor binding protein-3.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: NAS
    original_reference_id: PMID:14718574
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14718574
          supporting_text: 'Epub 2004 Jan 12. The human plasma proteome: a nonredundant
            list developed by combination of four separate sources.'
references:
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10766744
    title: Substitutions for hydrophobic amino acids in the N-terminal domains 
      of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic 
      actions.
    findings: []
  - id: PMID:11940579
    title: Insulin-like growth factor-binding protein-3 activates a 
      phosphotyrosine phosphatase. Effects on the insulin-like growth factor 
      signaling pathway.
    findings: []
  - id: PMID:11971816
    title: 'Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced
      apoptosis: role of Bcl-2 phosphorylation.'
    findings: []
  - id: PMID:12599210
    title: Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the
      differentiation of primary human adult skeletal myoblasts.
    findings: []
  - id: PMID:14561895
    title: Interaction between the Alzheimer's survival peptide humanin and 
      insulin-like growth factor-binding protein 3 regulates cell survival and 
      apoptosis.
    findings: []
  - id: PMID:14576163
    title: Insulin-like growth factor-independent effects mediated by a 
      C-terminal metal-binding domain of insulin-like growth factor binding 
      protein-3.
    findings: []
  - id: PMID:14718574
    title: 'The human plasma proteome: a nonredundant list developed by combination
      of four separate sources.'
    findings: []
  - id: PMID:17119061
    title: 'Ethnic disparity in the relationship between obesity and plasma insulin-like
      growth factors: the multiethnic cohort.'
    findings: []
  - id: PMID:17434920
    title: Contribution of the orphan nuclear receptor Nur77 to the apoptotic 
      action of IGFBP-3.
    findings: []
  - id: PMID:17591901
    title: 'The requirement of pax6 for postnatal eye development: evidence from experimental
      mouse chimeras.'
    findings: []
  - id: PMID:19258508
    title: NKX3.1 activates expression of insulin-like growth factor binding 
      protein-3 to mediate insulin-like growth factor-I signaling and cell 
      proliferation.
    findings: []
  - id: PMID:20353938
    title: Identification of a novel cell death receptor mediating 
      IGFBP-3-induced anti-tumor effects in breast and prostate cancer.
    findings: []
  - id: PMID:23178489
    title: The role of insulin-like growth factor binding protein-3 in the 
      breast cancer cell response to DNA-damaging agents.
    findings: []
  - id: PMID:26216267
    title: Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3
      (IGFBP3) and Regulates Its Interaction with Importin-β.
    findings: []
  - id: PMID:30184438
    title: Interaction of Insulin-Like Growth Factor-Binding Protein 3 With 
      Hyaluronan and Its Regulation by Humanin and CD44.
    findings: []
  - id: PMID:32814053
    title: Interactome Mapping Provides a Network of Neurodegenerative Disease 
      Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
    findings: []
  - id: PMID:9388210
    title: Inhibition of insulin receptor activation by insulin-like growth 
      factor binding proteins.
    findings: []
  - id: PMID:9497324
    title: Insulin-like growth factor (IGF)-binding protein 5 forms an 
      alternative ternary complex with IGFs and the acid-labile subunit.
    findings: []
  - id: Reactome:R-HSA-381435
    title: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS
    findings: []
  - id: Reactome:R-HSA-381446
    title: Thrombin proteolyzes IGF:IGFBP3:ALS
    findings: []
  - id: Reactome:R-HSA-381461
    title: Plasmin proteolyzes IGF:IGFBP-3:ALS
    findings: []
  - id: Reactome:R-HSA-381466
    title: 'Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS '
    findings: []
  - id: Reactome:R-HSA-381496
    title: Formation of the IGF:IGFBP3:ALS complex
    findings: []
  - id: Reactome:R-HSA-381500
    title: Cathepsin G proteolyzes IGF:IGFBP3:ALS
    findings: []
  - id: Reactome:R-HSA-6800035
    title: IGFBP3 binds TMEM219
    findings: []
  - id: Reactome:R-HSA-6800044
    title: TP53 stimulates IGFBP3 expression
    findings: []
  - id: Reactome:R-HSA-8952289
    title: FAM20C phosphorylates FAM20C substrates
    findings: []