IKBKB encodes IKK-beta, the principal catalytic serine/threonine kinase subunit of the IkappaB kinase (IKK) complex. Acting in the cytoplasm (with recruitment to receptor signaling complexes at the inner face of the plasma membrane and in membrane rafts), it phosphorylates the inhibitory IkappaB proteins on two critical serines, triggering their ubiquitin-dependent degradation and releasing NF-kappaB to enter the nucleus. It thereby transduces signals from inflammatory cytokine, Toll-like, antigen and other immune receptors into canonical NF-kappaB activation, controlling immunity, inflammation, proliferation and survival.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0002221 pattern recognition receptor signaling pathway | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Pattern recognition receptor signaling pathway. Reason: IKBKB acts downstream of PRRs toward NF-kappaB; non-core participation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0002223 stimulatory C-type lectin receptor signaling pathway | TAS Reactome:R-HSA-5621481 | KEEP AS NON CORE | Summary: Stimulatory C-type lectin receptor signaling. Reason: IKBKB acts downstream of CLRs; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS Reactome:R-HSA-1236974 | KEEP AS NON CORE | Summary: Antigen processing/presentation via MHC I (TAP-dependent). Reason: IKBKB contributes to immune antigen-presentation programs; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0002755 MyD88-dependent toll-like receptor signaling pathway | TAS Reactome:R-HSA-166058 | KEEP AS NON CORE | Summary: MyD88-dependent TLR signaling pathway. Reason: IKBKB is a downstream effector; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0002755 MyD88-dependent toll-like receptor signaling pathway | TAS Reactome:R-HSA-975871 | KEEP AS NON CORE | Summary: MyD88-dependent TLR signaling pathway. Reason: IKBKB is a downstream effector; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004672 protein kinase activity | IDA PMID:20434986 NLRC5 negatively regulates the NF-kappaB and type I interfer... | MODIFY | Summary: Protein kinase activity (InterPro). Reason: Correct but general; IKBKB is a serine/threonine kinase, a term already asserted. Proposed replacements: protein serine/threonine kinase activity Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | MODIFY | Summary: Protein kinase activity (InterPro). Reason: Correct but general; IKBKB is a serine/threonine kinase, a term already asserted. Proposed replacements: protein serine/threonine kinase activity Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | EXP PMID:18692471 Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mas... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | EXP PMID:23613522 IΞΊB kinase phosphorylation of SNAP-23 controls platelet secr... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:11297557 Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kin... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:12656673 The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:14673179 Dual effects of IkappaB kinase beta-mediated phosphorylation... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:15084260 IkappaB kinase promotes tumorigenesis through inhibition of ... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:25326418 Protein kinase IKKΞ²-catalyzed phosphorylation of IRF5 at Ser... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:25636800 Phosphorylation of innate immune adaptor proteins MAVS, STIN... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:32209697 Noncanonical STAT1 phosphorylation expands its transcription... | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | IEA GO_REF:0000003 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-168140 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-202541 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-209087 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-5228811 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-5357831 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9773803 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9860292 | ACCEPT | Summary: IKBKB is a protein serine/threonine kinase. Reason: Its catalytic class; phosphorylates substrates on serine. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:10521409 IkappaB kinases phosphorylate NF-kappaB p65 subunit on serin... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:10733566 Functional isoforms of IkappaB kinase alpha (IKKalpha) lacki... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:11297557 Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kin... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:11971985 Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivat... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:11971985 Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivat... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:12482991 betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires ph... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:12486103 The PAAD/PYRIN-family protein ASC is a dual regulator of a c... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:12486103 The PAAD/PYRIN-family protein ASC is a dual regulator of a c... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:12656673 The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:12656673 The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:12842894 Tumor necrosis factor-alpha-induced IKK phosphorylation of N... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:15084260 IkappaB kinase promotes tumorigenesis through inhibition of ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:15389287 A highly conserved proapoptotic gene, IKIP, located next to ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:15601829 Molecular mechanism of hTid-1, the human homolog of Drosophi... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:15601829 Molecular mechanism of hTid-1, the human homolog of Drosophi... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:15749833 Functional role of c-Src in IL-1-induced NF-kappa B activati... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16126728 Positive regulation of IkappaB kinase signaling by protein s... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16126728 Positive regulation of IkappaB kinase signaling by protein s... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16126728 Positive regulation of IkappaB kinase signaling by protein s... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16126728 Positive regulation of IkappaB kinase signaling by protein s... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16129692 Distinct protein phosphatase 2A heterotrimers modulate growt... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16129692 Distinct protein phosphatase 2A heterotrimers modulate growt... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16129692 Distinct protein phosphatase 2A heterotrimers modulate growt... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16129692 Distinct protein phosphatase 2A heterotrimers modulate growt... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16286467 Interleukin-1beta induction of NFkappaB is partially regulat... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16286467 Interleukin-1beta induction of NFkappaB is partially regulat... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16319058 Binding of manumycin A inhibits IkappaB kinase beta activity... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16319058 Binding of manumycin A inhibits IkappaB kinase beta activity... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16319058 Binding of manumycin A inhibits IkappaB kinase beta activity... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16365431 Modulation of TLR4 signaling by a novel adaptor protein sign... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16365431 Modulation of TLR4 signaling by a novel adaptor protein sign... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:16938294 Theileria-induced constitutive IKK activation is independent... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:17363973 Retroviral oncoprotein Tax deregulates NF-kappaB by activati... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:17568778 SINTBAD, a novel component of innate antiviral immunity, sha... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:17693255 IKK beta suppression of TSC1 links inflammation and tumor an... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:17939994 A role for IkappaB kinase 2 in bipolar spindle assembly. | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:18198944 The viral oncoprotein LMP1 exploits TRADD for signaling by m... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:18266467 Inhibition of IkappaB kinase by vaccinia virus virulence fac... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:18266467 Inhibition of IkappaB kinase by vaccinia virus virulence fac... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:18462684 Structure of a NEMO/IKK-associating domain reveals architect... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:18930133 PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNF... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:18930133 PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNF... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:19196987 Phosphorylation of p53 by IkappaB kinase 2 promotes its degr... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:19196987 Phosphorylation of p53 by IkappaB kinase 2 promotes its degr... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:19345327 Persistently activated Stat3 maintains constitutive NF-kappa... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:19365808 NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein. | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:19666608 A Legionella type IV effector activates the NF-kappaB pathwa... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:19675099 Ro52-mediated monoubiquitination of IKK{beta} down-regulates... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:19706536 Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:20098747 Expanding the substantial interactome of NEMO using protein ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:20211142 An atlas of combinatorial transcriptional regulation in mous... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:20368414 IKK{gamma} protein is a target of BAG3 regulatory activity i... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:20434986 NLRC5 negatively regulates the NF-kappaB and type I interfer... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:20434986 NLRC5 negatively regulates the NF-kappaB and type I interfer... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:20434986 NLRC5 negatively regulates the NF-kappaB and type I interfer... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:20600852 Suppression of NF-kappaB signaling by KEAP1 regulation of IK... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21399639 IKKΞ² phosphorylation regulates RPS3 nuclear translocation an... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21399639 IKKΞ² phosphorylation regulates RPS3 nuclear translocation an... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21423167 Crystal structure of inhibitor of ΞΊB kinase Ξ². | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21423167 Crystal structure of inhibitor of ΞΊB kinase Ξ². | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21474709 TRIM40 promotes neddylation of IKKΞ³ and is downregulated in ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21765415 The kinase IKKΞ± inhibits activation of the transcription fac... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:22037600 The IΞΊB kinase complex regulates the stability of cytokine-e... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:22037600 The IΞΊB kinase complex regulates the stability of cytokine-e... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:22810585 Viral immune modulators perturb the human molecular network ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:22904686 The germinal center kinase TNIK is required for canonical NF... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:23091055 The zinc finger protein ZNF268 is overexpressed in human cer... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:23104095 Immunodeficiency, autoinflammation and amylopectinosis in hu... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:24618592 Hepatitis B virus polymerase suppresses NF-ΞΊB signaling by i... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:25036637 A quantitative chaperone interaction network reveals the arc... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:25326418 Protein kinase IKKΞ²-catalyzed phosphorylation of IRF5 at Ser... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:25759022 A cytoplasmic NF-ΞΊB interacting long noncoding RNA blocks IΞΊ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:25852190 Integrative analysis of kinase networks in TRAIL-induced apo... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:25852190 Integrative analysis of kinase networks in TRAIL-induced apo... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:26212789 Chaperone-mediated autophagy prevents apoptosis by degrading... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:26334375 IFIT5 positively regulates NF-ΞΊB signaling through synergizi... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:27426725 LRRC14 attenuates Toll-like receptor-mediated NF-ΞΊB signalin... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:30833792 A protein-interaction network of interferon-stimulated genes... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:32209697 Noncanonical STAT1 phosphorylation expands its transcription... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:32935379 Negative regulation of NEMO signaling by the ubiquitin E3 li... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:33895773 RNA-induced liquid phase separation of SARS-CoV-2 nucleocaps... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:33895773 RNA-induced liquid phase separation of SARS-CoV-2 nucleocaps... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:38489235 WNT2B activates macrophages via NF-ΞΊB signaling pathway in i... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:9520446 NF-kappaB-inducing kinase activates IKK-alpha by phosphoryla... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:9520446 NF-kappaB-inducing kinase activates IKK-alpha by phosphoryla... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:9751060 IKK-gamma is an essential regulatory subunit of the IkappaB ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005515 protein binding | IPI PMID:9751060 IKK-gamma is an essential regulatory subunit of the IkappaB ... | REMOVE | Summary: Generic protein binding from many interaction studies. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by protein kinase binding, scaffold protein binding and homo/heterodimerization; removal does not dispute the interactions. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: ATP binding. Reason: Required cofactor binding for the kinase reaction; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0005634 nucleus | EXP PMID:20797629 Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiqu... | KEEP AS NON CORE | Summary: Nucleus. Reason: A nuclear pool of IKBKB is reported; non-core relative to cytoplasmic signaling. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005634 nucleus | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Nucleus. Reason: A nuclear pool of IKBKB is reported; non-core relative to cytoplasmic signaling. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005737 cytoplasm | EXP PMID:20797629 Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiqu... | ACCEPT | Summary: Cytoplasm. Reason: IKBKB is predominantly cytoplasmic, where the IKK complex acts. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: Cytoplasm. Reason: IKBKB is predominantly cytoplasmic, where the IKK complex acts. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005737 cytoplasm | IDA PMID:9804806 Role of IKK1 and IKK2 in lipopolysaccharide signaling in hum... | ACCEPT | Summary: Cytoplasm. Reason: IKBKB is predominantly cytoplasmic, where the IKK complex acts. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: Cytoplasm. Reason: IKBKB is predominantly cytoplasmic, where the IKK complex acts. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1168638 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-168140 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-168184 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-168910 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-193641 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-193703 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-193705 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-202500 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-202534 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-202541 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-209087 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730876 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-451561 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5228811 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5228840 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5262921 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357776 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357831 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5607742 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5609665 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5626962 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5684267 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5684275 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8863895 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9014343 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933530 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933539 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-937029 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-937032 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9749471 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9749494 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9749505 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9750226 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9750946 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-975119 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9754839 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9755734 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9758604 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9761344 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9773803 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9818789 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9836500 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9860292 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9861469 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9909510 | ACCEPT | Summary: Cytosol. Reason: The cytosol is the principal site of IKK-mediated IkappaB phosphorylation. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Cytoplasm |
| GO:0006468 protein phosphorylation | IDA PMID:15084260 IkappaB kinase promotes tumorigenesis through inhibition of ... | MODIFY | Summary: Protein phosphorylation (general). Reason: Correct but general; IKBKB specifically carries out peptidyl-serine phosphorylation, already asserted. Proposed replacements: peptidyl-serine phosphorylation Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0006468 protein phosphorylation | NAS PMID:9346484 IKK-1 and IKK-2: cytokine-activated IkappaB kinases essentia... | MODIFY | Summary: Protein phosphorylation (general). Reason: Correct but general; IKBKB specifically carries out peptidyl-serine phosphorylation, already asserted. Proposed replacements: peptidyl-serine phosphorylation Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0006954 inflammatory response | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Inflammatory response. Reason: NF-kappaB activation by IKBKB drives inflammation; broad downstream process. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0006954 inflammatory response | TAS PMID:18626576 The IkappaB kinase complex: master regulator of NF-kappaB si... | KEEP AS NON CORE | Summary: Inflammatory response. Reason: NF-kappaB activation by IKBKB drives inflammation; broad downstream process. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0007249 canonical NF-kappaB signal transduction | IDA PMID:20434986 NLRC5 negatively regulates the NF-kappaB and type I interfer... | ACCEPT | Summary: Canonical NF-kappaB signal transduction. Reason: IKBKB is essential for the canonical pathway; phosphorylating IkappaB to free NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0007249 canonical NF-kappaB signal transduction | IDA PMID:9346484 IKK-1 and IKK-2: cytokine-activated IkappaB kinases essentia... | ACCEPT | Summary: Canonical NF-kappaB signal transduction. Reason: IKBKB is essential for the canonical pathway; phosphorylating IkappaB to free NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0007249 canonical NF-kappaB signal transduction | IEA GO_REF:0000117 | ACCEPT | Summary: Canonical NF-kappaB signal transduction. Reason: IKBKB is essential for the canonical pathway; phosphorylating IkappaB to free NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0007249 canonical NF-kappaB signal transduction | IMP PMID:15383541 INCA, a novel human caspase recruitment domain protein that ... | ACCEPT | Summary: Canonical NF-kappaB signal transduction. Reason: IKBKB is essential for the canonical pathway; phosphorylating IkappaB to free NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0007249 canonical NF-kappaB signal transduction | IMP PMID:25816133 Tumor necrosis factor disrupts claudin-5 endothelial tight j... | ACCEPT | Summary: Canonical NF-kappaB signal transduction. Reason: IKBKB is essential for the canonical pathway; phosphorylating IkappaB to free NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0007249 canonical NF-kappaB signal transduction | TAS PMID:18626576 The IkappaB kinase complex: master regulator of NF-kappaB si... | ACCEPT | Summary: Canonical NF-kappaB signal transduction. Reason: IKBKB is essential for the canonical pathway; phosphorylating IkappaB to free NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0008384 IkappaB kinase activity | IDA PMID:9346484 IKK-1 and IKK-2: cytokine-activated IkappaB kinases essentia... | ACCEPT | Summary: IkappaB kinase activity, the defining catalytic function. Reason: IKBKB (IKK-beta) phosphorylates IkappaB on two critical serines, the core molecular function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0008384 IkappaB kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: IkappaB kinase activity, the defining catalytic function. Reason: IKBKB (IKK-beta) phosphorylates IkappaB on two critical serines, the core molecular function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0008384 IkappaB kinase activity | TAS PMID:11297557 Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kin... | ACCEPT | Summary: IkappaB kinase activity, the defining catalytic function. Reason: IKBKB (IKK-beta) phosphorylates IkappaB on two critical serines, the core molecular function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0008384 IkappaB kinase activity | TAS PMID:18626576 The IkappaB kinase complex: master regulator of NF-kappaB si... | ACCEPT | Summary: IkappaB kinase activity, the defining catalytic function. Reason: IKBKB (IKK-beta) phosphorylates IkappaB on two critical serines, the core molecular function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0008384 IkappaB kinase activity | TAS Reactome:R-HSA-5684267 | ACCEPT | Summary: IkappaB kinase activity, the defining catalytic function. Reason: IKBKB (IKK-beta) phosphorylates IkappaB on two critical serines, the core molecular function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0008384 IkappaB kinase activity | TAS Reactome:R-HSA-5684275 | ACCEPT | Summary: IkappaB kinase activity, the defining catalytic function. Reason: IKBKB (IKK-beta) phosphorylates IkappaB on two critical serines, the core molecular function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0008385 IkappaB kinase complex | IBA GO_REF:0000033 | ACCEPT | Summary: IKBKB is a catalytic subunit of the IkappaB kinase (IKK) complex. Reason: Its functional assembly; the canonical IKK complex. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0008385 IkappaB kinase complex | IEA GO_REF:0000117 | ACCEPT | Summary: IKBKB is a catalytic subunit of the IkappaB kinase (IKK) complex. Reason: Its functional assembly; the canonical IKK complex. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0008385 IkappaB kinase complex | IPI PMID:20434986 NLRC5 negatively regulates the NF-kappaB and type I interfer... | ACCEPT | Summary: IKBKB is a catalytic subunit of the IkappaB kinase (IKK) complex. Reason: Its functional assembly; the canonical IKK complex. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0008385 IkappaB kinase complex | TAS PMID:18626576 The IkappaB kinase complex: master regulator of NF-kappaB si... | ACCEPT | Summary: IKBKB is a catalytic subunit of the IkappaB kinase (IKK) complex. Reason: Its functional assembly; the canonical IKK complex. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0009615 response to virus | TAS PMID:18626576 The IkappaB kinase complex: master regulator of NF-kappaB si... | KEEP AS NON CORE | Summary: Response to virus. Reason: IKBKB participates in antiviral NF-kappaB responses; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0009898 cytoplasmic side of plasma membrane | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Cytoplasmic side of the plasma membrane. Reason: IKBKB is recruited to receptor signaling complexes at the inner leaflet; a non-core location (intracellular face). Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Membrane raft |
| GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway | TAS Reactome:R-HSA-5357905 | KEEP AS NON CORE | Summary: Regulation of TNF-mediated signaling. Reason: IKBKB modulates TNF-to-NF-kappaB signaling; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0018105 peptidyl-serine phosphorylation | IDA PMID:21399639 IKKΞ² phosphorylation regulates RPS3 nuclear translocation an... | ACCEPT | Summary: Peptidyl-serine phosphorylation. Reason: Direct catalytic output of IKBKB on substrate serines. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0018105 peptidyl-serine phosphorylation | IDA PMID:25326418 Protein kinase IKKΞ²-catalyzed phosphorylation of IRF5 at Ser... | ACCEPT | Summary: Peptidyl-serine phosphorylation. Reason: Direct catalytic output of IKBKB on substrate serines. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0019901 protein kinase binding | IPI PMID:12492477 Mixed lineage kinase LZK and antioxidant protein-1 activate ... | KEEP AS NON CORE | Summary: Protein kinase binding. Reason: IKBKB binds other kinases/substrate kinases in the pathway; informative but non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: TNF-mediated signaling pathway. Reason: IKBKB acts downstream of TNFR; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: TNF-mediated signaling pathway. Reason: IKBKB acts downstream of TNFR; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IMP PMID:12656673 The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-... | KEEP AS NON CORE | Summary: TNF-mediated signaling pathway. Reason: IKBKB acts downstream of TNFR; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IMP PMID:15084260 IkappaB kinase promotes tumorigenesis through inhibition of ... | KEEP AS NON CORE | Summary: TNF-mediated signaling pathway. Reason: IKBKB acts downstream of TNFR; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IMP PMID:25816133 Tumor necrosis factor disrupts claudin-5 endothelial tight j... | KEEP AS NON CORE | Summary: TNF-mediated signaling pathway. Reason: IKBKB acts downstream of TNFR; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0034121 regulation of toll-like receptor signaling pathway | TAS Reactome:R-HSA-9860276 | KEEP AS NON CORE | Summary: Regulation of TLR signaling pathway. Reason: IKBKB participates in and regulates TLR-to-NF-kappaB signaling; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0034138 toll-like receptor 3 signaling pathway | TAS Reactome:R-HSA-168164 | KEEP AS NON CORE | Summary: Toll-like receptor 3 signaling pathway. Reason: IKBKB acts downstream of TLR3; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0035631 CD40 receptor complex | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: CD40 receptor complex. Reason: IKBKB is recruited to the CD40 signaling complex; non-core location. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0035666 TRIF-dependent toll-like receptor signaling pathway | TAS Reactome:R-HSA-937061 | KEEP AS NON CORE | Summary: TRIF-dependent TLR signaling pathway. Reason: IKBKB is a downstream effector; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0038095 Fc-epsilon receptor signaling pathway | TAS Reactome:R-HSA-2454202 | KEEP AS NON CORE | Summary: Fc-epsilon receptor signaling pathway. Reason: IKBKB acts downstream of FcepsilonR; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0042802 identical protein binding | IPI PMID:16319058 Binding of manumycin A inhibits IkappaB kinase beta activity... | ACCEPT | Summary: Identical protein binding (homodimerization). Reason: IKBKB self-associates within the IKK complex. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0042802 identical protein binding | IPI PMID:21423167 Crystal structure of inhibitor of ΞΊB kinase Ξ². | ACCEPT | Summary: Identical protein binding (homodimerization). Reason: IKBKB self-associates within the IKK complex. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0042802 identical protein binding | IPI PMID:23776406 A structural basis for IΞΊB kinase 2 activation via oligomeri... | ACCEPT | Summary: Identical protein binding (homodimerization). Reason: IKBKB self-associates within the IKK complex. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0042803 protein homodimerization activity | IDA PMID:23091055 The zinc finger protein ZNF268 is overexpressed in human cer... | ACCEPT | Summary: Protein homodimerization activity. Reason: IKBKB forms homodimers as part of IKK assembly. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: Positive regulation of canonical NF-kappaB signaling. Reason: IKBKB activity is the key positive step activating NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IDA PMID:12656673 The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-... | ACCEPT | Summary: Positive regulation of canonical NF-kappaB signaling. Reason: IKBKB activity is the key positive step activating NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IDA PMID:9346484 IKK-1 and IKK-2: cytokine-activated IkappaB kinases essentia... | ACCEPT | Summary: Positive regulation of canonical NF-kappaB signaling. Reason: IKBKB activity is the key positive step activating NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IMP PMID:30337470 Gain-of-function IKBKB mutation causes human combined immune... | ACCEPT | Summary: Positive regulation of canonical NF-kappaB signaling. Reason: IKBKB activity is the key positive step activating NF-kappaB. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0045087 innate immune response | TAS PMID:18626576 The IkappaB kinase complex: master regulator of NF-kappaB si... | KEEP AS NON CORE | Summary: Innate immune response. Reason: IKBKB is central to innate immune NF-kappaB responses; broad downstream process. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0045121 membrane raft | EXP PMID:17287217 Caveolin-1 triggers T-cell activation via CD26 in associatio... | KEEP AS NON CORE | Summary: Membrane raft. Reason: IKBKB localizes to raft-associated receptor signaling complexes; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Membrane raft |
| GO:0045121 membrane raft | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Membrane raft. Reason: IKBKB localizes to raft-associated receptor signaling complexes; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Membrane raft |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:15790681 Foxp3 interacts with nuclear factor of activated T cells and... | KEEP AS NON CORE | Summary: Positive regulation of DNA-templated transcription. Reason: Via NF-kappaB activation; downstream, non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0045893 positive regulation of DNA-templated transcription | NAS PMID:9346484 IKK-1 and IKK-2: cytokine-activated IkappaB kinases essentia... | KEEP AS NON CORE | Summary: Positive regulation of DNA-templated transcription. Reason: Via NF-kappaB activation; downstream, non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0045893 positive regulation of DNA-templated transcription | NAS PMID:9346485 IkappaB kinase-beta: NF-kappaB activation and complex format... | KEEP AS NON CORE | Summary: Positive regulation of DNA-templated transcription. Reason: Via NF-kappaB activation; downstream, non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0045893 positive regulation of DNA-templated transcription | NAS PMID:9813230 IkappaB kinase-alpha and -beta genes are coexpressed in adul... | KEEP AS NON CORE | Summary: Positive regulation of DNA-templated transcription. Reason: Via NF-kappaB activation; downstream, non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: Via NF-kappaB activation; downstream, non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:23091055 The zinc finger protein ZNF268 is overexpressed in human cer... | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: Via NF-kappaB activation; downstream, non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:23453807 The E3 ligase parkin maintains mitochondrial integrity by in... | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: Via NF-kappaB activation; downstream, non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt free NF-kappa-B is translocated into the |
| GO:0046982 protein heterodimerization activity | IDA PMID:23091055 The zinc finger protein ZNF268 is overexpressed in human cer... | KEEP AS NON CORE | Summary: Protein heterodimerization activity (with IKK-alpha). Reason: IKBKB heterodimerizes with IKK-alpha in the IKK complex; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0050852 T cell receptor signaling pathway | TAS Reactome:R-HSA-202403 | KEEP AS NON CORE | Summary: T cell receptor signaling pathway. Reason: IKBKB links TCR to NF-kappaB; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0051403 stress-activated MAPK cascade | TAS Reactome:R-HSA-450294 | KEEP AS NON CORE | Summary: Stress-activated MAPK cascade. Reason: IKBKB participates in stress signaling crosstalk; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0051604 protein maturation | IDA PMID:11297557 Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kin... | KEEP AS NON CORE | Summary: Protein maturation (NF-kappaB1 p105 processing). Reason: IKBKB phosphorylation promotes NF-kappaB precursor processing; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0070498 interleukin-1-mediated signaling pathway | IMP PMID:25816133 Tumor necrosis factor disrupts claudin-5 endothelial tight j... | KEEP AS NON CORE | Summary: Interleukin-1-mediated signaling pathway. Reason: IKBKB acts downstream of IL-1R; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0070498 interleukin-1-mediated signaling pathway | TAS Reactome:R-HSA-9020702 | KEEP AS NON CORE | Summary: Interleukin-1-mediated signaling pathway. Reason: IKBKB acts downstream of IL-1R; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0071356 cellular response to tumor necrosis factor | IDA PMID:23091055 The zinc finger protein ZNF268 is overexpressed in human cer... | KEEP AS NON CORE | Summary: Cellular response to TNF. Reason: IKBKB mediates cellular TNF responses via NF-kappaB; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0072659 protein localization to plasma membrane | IMP PMID:25816133 Tumor necrosis factor disrupts claudin-5 endothelial tight j... | KEEP AS NON CORE | Summary: Protein localization to plasma membrane. Reason: IKBKB signaling influences membrane localization of partners; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:0097110 scaffold protein binding | IDA PMID:23776175 SASH1 is a scaffold molecule in endothelial TLR4 signaling. | KEEP AS NON CORE | Summary: Scaffold protein binding (e.g. NEMO/IKBKG). Reason: IKBKB binds the NEMO scaffold within the IKK complex; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0097110 scaffold protein binding | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Scaffold protein binding (e.g. NEMO/IKBKG). Reason: IKBKB binds the NEMO scaffold within the IKK complex; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt canonical IKK complex |
| GO:0106310 protein serine kinase activity | EXP PMID:25326418 Protein kinase IKKΞ²-catalyzed phosphorylation of IRF5 at Ser... | ACCEPT | Summary: Protein serine kinase activity. Reason: IKBKB phosphorylates serine residues (RHEA-backed); consistent with its IkappaB kinase function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:0106310 protein serine kinase activity | IEA GO_REF:0000116 | ACCEPT | Summary: Protein serine kinase activity. Reason: IKBKB phosphorylates serine residues (RHEA-backed); consistent with its IkappaB kinase function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Phosphorylates inhibitors of NF-kappa-B on |
| GO:1900016 negative regulation of cytokine production involved in inflammatory response | IDA PMID:16968406 Nicotine inhibits the production of proinflammatory mediator... | KEEP AS NON CORE | Summary: Negative regulation of cytokine production in inflammation. Reason: IKBKB has context-dependent negative regulatory roles; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:1903140 regulation of establishment of endothelial barrier | IMP PMID:25816133 Tumor necrosis factor disrupts claudin-5 endothelial tight j... | KEEP AS NON CORE | Summary: Regulation of endothelial barrier establishment. Reason: IKBKB/NF-kappaB affects endothelial barrier; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:1903347 negative regulation of bicellular tight junction assembly | IMP PMID:25816133 Tumor necrosis factor disrupts claudin-5 endothelial tight j... | KEEP AS NON CORE | Summary: Negative regulation of tight junction assembly. Reason: IKBKB signaling modulates tight junctions; non-core. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:1990459 transferrin receptor binding | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Transferrin receptor binding. Reason: A specific reported interaction (IPI); non-core and peripheral to kinase function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
| GO:1990459 transferrin receptor binding | IPI PMID:23016877 TfR1 interacts with the IKK complex and is involved in IKK-N... | KEEP AS NON CORE | Summary: Transferrin receptor binding. Reason: A specific reported interaction (IPI); non-core and peripheral to kinase function. Supporting Evidence: file:human/IKBKB/IKBKB-uniprot.txt Serine kinase that plays an essential role in the NF-kappa-B |
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Download this section (compressed HTML)Q: How is IKK-beta substrate selectivity (IkappaB versus RELA, NFKB1, TBK1, IKBKE) controlled within and beyond the IKK complex?
Q: What distinguishes membrane-raft/receptor-recruited IKK-beta activity from the bulk cytosolic pool?
Experiment: Analog-sensitive IKK-beta plus phosphoproteomics to define its direct substrate set in different receptor contexts.
Type: proteomics
Experiment: Reconstitute the IKK complex (IKKA/IKKB/NEMO) and measure IkappaB phosphorylation kinetics with and without upstream activating kinases.
Type: biochemistry
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Download this section (compressed HTML)