IL6 encodes interleukin-6, a secreted pleiotropic cytokine central to immunity, the acute-phase response, haematopoiesis, tissue regeneration and metabolism. It binds the interleukin-6 receptor (IL6R) and the resulting complex engages the signal-transducing subunit IL6ST/gp130 (in membrane-bound classic, soluble-receptor trans-, and cell-contact cluster signaling), activating the JAK-STAT3 (and MAPK/PI3K) cascades. IL6 drives B- and T-cell responses, hepatic acute-phase protein synthesis and a very wide range of inflammatory and homeostatic programs.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001781 neutrophil apoptotic process | IDA PMID:7595060 Interleukin-6 suppression of neutrophil apoptosis is neutrop... | KEEP AS NON CORE | Summary: Neutrophil apoptotic process. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (neutrophil apoptotic process); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0001960 negative regulation of cytokine-mediated signaling pathway | NAS PMID:8702737 Influence of interleukin-6 (IL-6) dimerization on formation ... | KEEP AS NON CORE | Summary: Negative regulation of cytokine-mediated signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of cytokine-mediated signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002314 germinal center B cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Germinal center B cell differentiation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (germinal center B cell differentiation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002384 hepatic immune response | IDA PMID:2444978 Interferon beta 2/B-cell stimulatory factor type 2 shares id... | KEEP AS NON CORE | Summary: Hepatic immune response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (hepatic immune response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002384 hepatic immune response | TAS PMID:12832423 Cellular cholesterol depletion triggers shedding of the huma... | KEEP AS NON CORE | Summary: Hepatic immune response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (hepatic immune response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002446 neutrophil mediated immunity | TAS PMID:16034137 Bacterial induction of TNF-alpha converting enzyme expressio... | KEEP AS NON CORE | Summary: Neutrophil mediated immunity. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (neutrophil mediated immunity); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002548 monocyte chemotaxis | IC PMID:10510402 Novel path to activation of vascular smooth muscle cells: up... | KEEP AS NON CORE | Summary: Monocyte chemotaxis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (monocyte chemotaxis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002639 positive regulation of immunoglobulin production | IDA PMID:3491322 Complementary DNA for a novel human interleukin (BSF-2) that... | KEEP AS NON CORE | Summary: Positive regulation of immunoglobulin production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of immunoglobulin production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002639 positive regulation of immunoglobulin production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of immunoglobulin production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of immunoglobulin production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002675 positive regulation of acute inflammatory response | IDA PMID:2444978 Interferon beta 2/B-cell stimulatory factor type 2 shares id... | KEEP AS NON CORE | Summary: Positive regulation of acute inflammatory response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of acute inflammatory response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0002690 positive regulation of leukocyte chemotaxis | TAS PMID:16034137 Bacterial induction of TNF-alpha converting enzyme expressio... | KEEP AS NON CORE | Summary: Positive regulation of leukocyte chemotaxis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of leukocyte chemotaxis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | IBA GO_REF:0000033 | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | IDA PMID:12829785 Hexameric structure and assembly of the interleukin-6/IL-6 a... | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | IDA PMID:27830702 Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-... | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | IDA PMID:3023045 Structure and expression of cDNA and genes for human interfe... | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | IDA PMID:3491322 Complementary DNA for a novel human interleukin (BSF-2) that... | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | IEA GO_REF:0000120 | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | ISS GO_REF:0000024 | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | NAS PMID:10443688 Tumor necrosis factor alpha decreases, and interleukin-10 in... | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005125 cytokine activity | TAS PMID:28720735 A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a N... | ACCEPT | Summary: IL6 is a cytokine. Reason: Its defining molecular function as a secreted immune cytokine. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005138 interleukin-6 receptor binding | IEA GO_REF:0000120 | ACCEPT | Summary: IL6 binds the interleukin-6 receptor (IL6R). Reason: Receptor-ligand binding to IL6R initiating signaling; core function. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Binds to IL6R, then the |
| GO:0005138 interleukin-6 receptor binding | IPI PMID:12829785 Hexameric structure and assembly of the interleukin-6/IL-6 a... | ACCEPT | Summary: IL6 binds the interleukin-6 receptor (IL6R). Reason: Receptor-ligand binding to IL6R initiating signaling; core function. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Binds to IL6R, then the |
| GO:0005138 interleukin-6 receptor binding | IPI PMID:12829785 Hexameric structure and assembly of the interleukin-6/IL-6 a... | ACCEPT | Summary: IL6 binds the interleukin-6 receptor (IL6R). Reason: Receptor-ligand binding to IL6R initiating signaling; core function. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Binds to IL6R, then the |
| GO:0005138 interleukin-6 receptor binding | NAS PMID:1883960 Marked cell-type-specific differences in glycosylation of hu... | ACCEPT | Summary: IL6 binds the interleukin-6 receptor (IL6R). Reason: Receptor-ligand binding to IL6R initiating signaling; core function. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Binds to IL6R, then the |
| GO:0005138 interleukin-6 receptor binding | TAS PMID:10925276 Loss of IL-6 receptor expression in cervical carcinoma cells... | ACCEPT | Summary: IL6 binds the interleukin-6 receptor (IL6R). Reason: Receptor-ligand binding to IL6R initiating signaling; core function. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Binds to IL6R, then the |
| GO:0005515 protein binding | IPI PMID:11238858 Detection of direct binding of human herpesvirus 8-encoded i... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:12829785 Hexameric structure and assembly of the interleukin-6/IL-6 a... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:12829785 Hexameric structure and assembly of the interleukin-6/IL-6 a... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:18775332 Structural organization of a full-length gp130/LIF-R cytokin... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:18775332 Structural organization of a full-length gp130/LIF-R cytokin... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:25401472 Targeting sortilin in immune cells reduces proinflammatory c... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:28265003 SorLA in Interleukin-6 Signaling and Turnover. | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:28265003 SorLA in Interleukin-6 Signaling and Turnover. | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:32822567 A Human IgSF Cell-Surface Interactome Reveals a Complex Netw... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:32822567 A Human IgSF Cell-Surface Interactome Reveals a Complex Netw... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:36930708 Structural insights into the assembly of gp130 family cytoki... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:36930708 Structural insights into the assembly of gp130 family cytoki... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:8702737 Influence of interleukin-6 (IL-6) dimerization on formation ... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005515 protein binding | IPI PMID:8702737 Influence of interleukin-6 (IL-6) dimerization on formation ... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IL6 receptor binding and receptor-complex membership. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0005576 extracellular region | EXP PMID:11080265 Production of interleukin-6 in contracting human skeletal mu... | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | IBA GO_REF:0000033 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | IDA PMID:10443688 Tumor necrosis factor alpha decreases, and interleukin-10 in... | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | IDA PMID:16034137 Bacterial induction of TNF-alpha converting enzyme expressio... | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | IDA PMID:27830702 Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-... | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | IDA PMID:3023045 Structure and expression of cDNA and genes for human interfe... | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | IEA GO_REF:0000120 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | ISS PMID:27893700 Trans-presentation of IL-6 by dendritic cells is required fo... | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1067640 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1067651 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1067659 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1067667 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1067676 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1067688 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112510 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112514 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112565 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112602 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112604 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112690 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112703 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112708 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112727 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1112755 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-3790130 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-6784160 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-6789524 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-6789615 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9662710 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9958871 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9958875 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9958877 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9958878 | ACCEPT | Summary: IL6 is a secreted, extracellular cytokine. Reason: It is secreted and acts extracellularly on target-cell receptors. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005788 endoplasmic reticulum lumen | TAS Reactome:R-HSA-8952289 | KEEP AS NON CORE | Summary: Endoplasmic reticulum lumen. Reason: Transit location during IL6 biosynthesis/secretion; non-core. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Secreted |
| GO:0005886 plasma membrane | NAS PMID:36930708 Structural insights into the assembly of gp130 family cytoki... | KEEP AS NON CORE | Summary: Plasma membrane. Reason: Reflects membrane-bound IL6:IL6R complexes in classic/cluster signaling; IL6 itself is a secreted ligand, so this is non-core. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0005896 interleukin-6 receptor complex | IDA PMID:12829785 Hexameric structure and assembly of the interleukin-6/IL-6 a... | ACCEPT | Summary: IL6 is part of the interleukin-6 receptor complex. Reason: It assembles with IL6R and IL6ST/gp130 into the signaling receptor complex. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0005896 interleukin-6 receptor complex | IDA PMID:2261637 Molecular cloning and expression of an IL-6 signal transduce... | ACCEPT | Summary: IL6 is part of the interleukin-6 receptor complex. Reason: It assembles with IL6R and IL6ST/gp130 into the signaling receptor complex. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0005896 interleukin-6 receptor complex | IPI PMID:36930708 Structural insights into the assembly of gp130 family cytoki... | ACCEPT | Summary: IL6 is part of the interleukin-6 receptor complex. Reason: It assembles with IL6R and IL6ST/gp130 into the signaling receptor complex. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0005896 interleukin-6 receptor complex | NAS PMID:30279168 Soluble gp130 prevents interleukin-6 and interleukin-11 clus... | ACCEPT | Summary: IL6 is part of the interleukin-6 receptor complex. Reason: It assembles with IL6R and IL6ST/gp130 into the signaling receptor complex. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0005896 interleukin-6 receptor complex | NAS PMID:36930708 Structural insights into the assembly of gp130 family cytoki... | ACCEPT | Summary: IL6 is part of the interleukin-6 receptor complex. Reason: It assembles with IL6R and IL6ST/gp130 into the signaling receptor complex. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0006953 acute-phase response | TAS PMID:12832423 Cellular cholesterol depletion triggers shedding of the huma... | KEEP AS NON CORE | Summary: Acute-phase response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (acute-phase response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0006954 inflammatory response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Inflammatory response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (inflammatory response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0006954 inflammatory response | IDA PMID:10443688 Tumor necrosis factor alpha decreases, and interleukin-10 in... | KEEP AS NON CORE | Summary: Inflammatory response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (inflammatory response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0006954 inflammatory response | NAS PMID:24418198 Inhibition of IL-6 family cytokines by SOCS3. | KEEP AS NON CORE | Summary: Inflammatory response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (inflammatory response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0006954 inflammatory response | TAS PMID:28720735 A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a N... | KEEP AS NON CORE | Summary: Inflammatory response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (inflammatory response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0006955 immune response | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Immune response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (immune response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0006959 humoral immune response | IC PMID:3491322 Complementary DNA for a novel human interleukin (BSF-2) that... | KEEP AS NON CORE | Summary: Humoral immune response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (humoral immune response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:31101051 Response to IL-6 trans- and IL-6 classic signalling is deter... | ACCEPT | Summary: Cell surface receptor signaling via JAK-STAT. Reason: IL6/gp130 signals through the JAK-STAT3 cascade, its principal signaling mechanism. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IMP PMID:28433754 miR-146a suppresses STAT3/VEGF pathways and reduces apoptosi... | ACCEPT | Summary: Cell surface receptor signaling via JAK-STAT. Reason: IL6/gp130 signals through the JAK-STAT3 cascade, its principal signaling mechanism. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0008083 growth factor activity | IDA PMID:12643274 Signaling of human ciliary neurotrophic factor (CNTF) revisi... | KEEP AS NON CORE | Summary: Growth factor activity. Reason: IL6 has growth-promoting activity on some cell types; a parallel, non-core classification of its ligand activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0008083 growth factor activity | IDA PMID:2261637 Molecular cloning and expression of an IL-6 signal transduce... | KEEP AS NON CORE | Summary: Growth factor activity. Reason: IL6 has growth-promoting activity on some cell types; a parallel, non-core classification of its ligand activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0008083 growth factor activity | TAS PMID:2829354 Monocyte-derived human B-cell growth factor identified as in... | KEEP AS NON CORE | Summary: Growth factor activity. Reason: IL6 has growth-promoting activity on some cell types; a parallel, non-core classification of its ligand activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0008284 positive regulation of cell population proliferation | IDA PMID:2261637 Molecular cloning and expression of an IL-6 signal transduce... | KEEP AS NON CORE | Summary: Positive regulation of cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0008284 positive regulation of cell population proliferation | IDA PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | KEEP AS NON CORE | Summary: Positive regulation of cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:25809226 Down-regulation of microRNA-9 leads to activation of IL-6/Ja... | KEEP AS NON CORE | Summary: Positive regulation of cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:18719127 Interleukin-6 regulates pancreatic alpha-cell mass expansion... | KEEP AS NON CORE | Summary: Positive regulation of cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0008285 negative regulation of cell population proliferation | TAS PMID:3023045 Structure and expression of cDNA and genes for human interfe... | KEEP AS NON CORE | Summary: Negative regulation of cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0010573 vascular endothelial growth factor production | IDA PMID:12794819 Anti-interleukin-6 receptor antibody therapy reduces vascula... | KEEP AS NON CORE | Summary: VEGF production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (VEGF production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0010574 regulation of vascular endothelial growth factor production | IDA PMID:8557680 Interleukin 6 induces the expression of vascular endothelial... | KEEP AS NON CORE | Summary: Regulation of VEGF production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (regulation of VEGF production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0010575 positive regulation of vascular endothelial growth factor production | IMP PMID:28433754 miR-146a suppresses STAT3/VEGF pathways and reduces apoptosi... | KEEP AS NON CORE | Summary: Positive regulation of VEGF production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of VEGF production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0010628 positive regulation of gene expression | IDA PMID:27252421 Plasma miR-26a as a Diagnostic Biomarker Regulates Cytokine ... | KEEP AS NON CORE | Summary: Positive regulation of gene expression. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of gene expression); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0010628 positive regulation of gene expression | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | KEEP AS NON CORE | Summary: Positive regulation of gene expression. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of gene expression); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0010718 positive regulation of epithelial to mesenchymal transition | IDA PMID:25916550 Epigenetic silencing of microRNA-149 in cancer-associated fi... | KEEP AS NON CORE | Summary: Positive regulation of EMT. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of EMT); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0010888 negative regulation of lipid storage | NAS PMID:16464856 Cytokines promote Wnt signaling and inflammation and impair ... | KEEP AS NON CORE | Summary: Negative regulation of lipid storage. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of lipid storage); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0014823 response to activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Response to activity. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (response to activity); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:12643274 Signaling of human ciliary neurotrophic factor (CNTF) revisi... | TOO GENERAL | Summary: Cytokine-mediated signaling pathway. Reason: The specific interleukin-6-mediated signaling pathway is asserted and entails this general term. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:2261637 Molecular cloning and expression of an IL-6 signal transduce... | TOO GENERAL | Summary: Cytokine-mediated signaling pathway. Reason: The specific interleukin-6-mediated signaling pathway is asserted and entails this general term. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0030154 cell differentiation | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Cell differentiation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (cell differentiation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0030168 platelet activation | TAS PMID:7831669 Platelet activation induced by interleukin-6: evidence for a... | KEEP AS NON CORE | Summary: Platelet activation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (platelet activation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0031018 endocrine pancreas development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Endocrine pancreas development. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (endocrine pancreas development); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0031175 neuron projection development | IMP PMID:3264880 Induction of neuronal differentiation in PC12 cells by B-cel... | KEEP AS NON CORE | Summary: Neuron projection development. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (neuron projection development); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032494 response to peptidoglycan | NAS PMID:16034137 Bacterial induction of TNF-alpha converting enzyme expressio... | KEEP AS NON CORE | Summary: Response to peptidoglycan. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (response to peptidoglycan); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032682 negative regulation of chemokine production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of chemokine production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of chemokine production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032722 positive regulation of chemokine production | IDA PMID:10510402 Novel path to activation of vascular smooth muscle cells: up... | KEEP AS NON CORE | Summary: Positive regulation of chemokine production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of chemokine production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032722 positive regulation of chemokine production | NAS PMID:16034137 Bacterial induction of TNF-alpha converting enzyme expressio... | KEEP AS NON CORE | Summary: Positive regulation of chemokine production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of chemokine production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032731 positive regulation of interleukin-1 beta production | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | KEEP AS NON CORE | Summary: Positive regulation of IL-1 beta production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of IL-1 beta production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032733 positive regulation of interleukin-10 production | IDA PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | KEEP AS NON CORE | Summary: Positive regulation of IL-10 production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of IL-10 production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032740 positive regulation of interleukin-17 production | ISS PMID:25362566 miR26a modulates Th17/T reg balance in the EAE model of mult... | KEEP AS NON CORE | Summary: Positive regulation of IL-17 production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of IL-17 production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032745 positive regulation of interleukin-21 production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of IL-21 production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of IL-21 production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032755 positive regulation of interleukin-6 production | IDA PMID:10510402 Novel path to activation of vascular smooth muscle cells: up... | KEEP AS NON CORE | Summary: Positive regulation of IL-6 production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of IL-6 production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032757 positive regulation of interleukin-8 production | IDA PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | KEEP AS NON CORE | Summary: Positive regulation of IL-8 production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of IL-8 production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032760 positive regulation of tumor necrosis factor production | IDA PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | KEEP AS NON CORE | Summary: Positive regulation of TNF production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of TNF production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0032966 negative regulation of collagen biosynthetic process | IDA PMID:12419823 JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)... | KEEP AS NON CORE | Summary: Negative regulation of collagen biosynthesis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of collagen biosynthesis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0033138 positive regulation of peptidyl-serine phosphorylation | IDA PMID:7508917 Mitogen-activated protein kinases and ribosomal S6 protein k... | KEEP AS NON CORE | Summary: Positive regulation of peptidyl-serine phosphorylation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of peptidyl-serine phosphorylation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0035425 autocrine signaling | NAS PMID:33471392 Increased IL-6 and Potential IL-6 trans-signalling in the ai... | KEEP AS NON CORE | Summary: Autocrine signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (autocrine signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0035633 maintenance of blood-brain barrier | TAS PMID:29702085 TNF-Ξ±-sensitive brain pericytes activate microglia by releas... | KEEP AS NON CORE | Summary: Maintenance of blood-brain barrier. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (maintenance of blood-brain barrier); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0038001 paracrine signaling | NAS PMID:35371975 IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biolog... | KEEP AS NON CORE | Summary: Paracrine signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (paracrine signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0042102 positive regulation of T cell proliferation | IDA PMID:3130269 Synergistic activation of human T cells by interleukin 1 and... | KEEP AS NON CORE | Summary: Positive regulation of T cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of T cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0042593 glucose homeostasis | IDA PMID:22037645 Interleukin-6 enhances insulin secretion by increasing gluca... | KEEP AS NON CORE | Summary: Glucose homeostasis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (glucose homeostasis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0042802 identical protein binding | IPI PMID:8702737 Influence of interleukin-6 (IL-6) dimerization on formation ... | KEEP AS NON CORE | Summary: Identical protein binding. Reason: IL6 associates within higher-order receptor complexes; non-core. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Binds to IL6R, then the |
| GO:0043065 positive regulation of apoptotic process | IDA PMID:9949178 Both Stat3-activation and Stat3-independent BCL2 downregulat... | KEEP AS NON CORE | Summary: Positive regulation of apoptosis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of apoptosis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0043066 negative regulation of apoptotic process | IDA PMID:7595060 Interleukin-6 suppression of neutrophil apoptosis is neutrop... | KEEP AS NON CORE | Summary: Negative regulation of apoptosis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of apoptosis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:12419823 JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)... | KEEP AS NON CORE | Summary: Positive regulation of MAPK cascade. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of MAPK cascade); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:7508917 Mitogen-activated protein kinases and ribosomal S6 protein k... | KEEP AS NON CORE | Summary: Positive regulation of MAPK cascade. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of MAPK cascade); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045599 negative regulation of fat cell differentiation | NAS PMID:16464856 Cytokines promote Wnt signaling and inflammation and impair ... | KEEP AS NON CORE | Summary: Negative regulation of fat cell differentiation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of fat cell differentiation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045669 positive regulation of osteoblast differentiation | TAS PMID:12372336 Gp130 activation by soluble interleukin-6 receptor/interleuk... | KEEP AS NON CORE | Summary: Positive regulation of osteoblast differentiation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of osteoblast differentiation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045727 positive regulation of translation | IDA PMID:16732314 BCL3 is induced by IL-6 via Stat3 binding to intronic enhanc... | KEEP AS NON CORE | Summary: Positive regulation of translation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of translation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045765 regulation of angiogenesis | IC PMID:8557680 Interleukin 6 induces the expression of vascular endothelial... | KEEP AS NON CORE | Summary: Regulation of angiogenesis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (regulation of angiogenesis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045779 negative regulation of bone resorption | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of bone resorption. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of bone resorption); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:16606666 B7-H4 expression identifies a novel suppressive macrophage p... | KEEP AS NON CORE | Summary: Positive regulation of DNA-templated transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of DNA-templated transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:17875732 Relationship between B7-H4, regulatory T cells, and patient ... | KEEP AS NON CORE | Summary: Positive regulation of DNA-templated transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of DNA-templated transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:16946298 STAT3 mediates hepatic hepcidin expression and its inflammat... | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of Pol II transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of Pol II transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:7508917 Mitogen-activated protein kinases and ribosomal S6 protein k... | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of Pol II transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:7749983 Cross-linking of OX40 ligand, a member of the TNF/NGF cytoki... | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of Pol II transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of Pol II transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of Pol II transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of Pol II transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | IC PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | KEEP AS NON CORE | Summary: Positive regulation of JAK-STAT signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of JAK-STAT signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | IDA PMID:12419823 JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)... | KEEP AS NON CORE | Summary: Positive regulation of JAK-STAT signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of JAK-STAT signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | IDA PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | KEEP AS NON CORE | Summary: Positive regulation of JAK-STAT signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of JAK-STAT signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0048661 positive regulation of smooth muscle cell proliferation | IDA PMID:10510402 Novel path to activation of vascular smooth muscle cells: up... | KEEP AS NON CORE | Summary: Positive regulation of smooth muscle cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of smooth muscle cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation | IDA PMID:7508917 Mitogen-activated protein kinases and ribosomal S6 protein k... | KEEP AS NON CORE | Summary: Positive regulation of peptidyl-tyrosine phosphorylation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of peptidyl-tyrosine phosphorylation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0050768 negative regulation of neurogenesis | TAS PMID:20018408 Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis i... | KEEP AS NON CORE | Summary: Negative regulation of neurogenesis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of neurogenesis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0050796 regulation of insulin secretion | IDA PMID:22037645 Interleukin-6 enhances insulin secretion by increasing gluca... | KEEP AS NON CORE | Summary: Regulation of insulin secretion. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (regulation of insulin secretion); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0050796 regulation of insulin secretion | NAS PMID:29508109 IL-6 signalling pathways and the development of type 2 diabe... | KEEP AS NON CORE | Summary: Regulation of insulin secretion. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (regulation of insulin secretion); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0050829 defense response to Gram-negative bacterium | TAS PMID:16034137 Bacterial induction of TNF-alpha converting enzyme expressio... | KEEP AS NON CORE | Summary: Defense response to Gram-negative bacterium. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (defense response to Gram-negative bacterium); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0050830 defense response to Gram-positive bacterium | TAS PMID:16034137 Bacterial induction of TNF-alpha converting enzyme expressio... | KEEP AS NON CORE | Summary: Defense response to Gram-positive bacterium. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (defense response to Gram-positive bacterium); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0050871 positive regulation of B cell activation | IDA PMID:3491322 Complementary DNA for a novel human interleukin (BSF-2) that... | KEEP AS NON CORE | Summary: Positive regulation of B cell activation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of B cell activation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0051251 positive regulation of lymphocyte activation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Positive regulation of lymphocyte activation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of lymphocyte activation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0051384 response to glucocorticoid | IDA PMID:10443688 Tumor necrosis factor alpha decreases, and interleukin-10 in... | KEEP AS NON CORE | Summary: Response to glucocorticoid. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (response to glucocorticoid); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0051607 defense response to virus | IDA PMID:3023045 Structure and expression of cDNA and genes for human interfe... | KEEP AS NON CORE | Summary: Defense response to virus. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (defense response to virus); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0060252 positive regulation of glial cell proliferation | IDA PMID:2104886 Proliferation of astrocytes in vitro in response to cytokine... | KEEP AS NON CORE | Summary: Positive regulation of glial cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of glial cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0061470 T follicular helper cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: T follicular helper cell differentiation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (T follicular helper cell differentiation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0061888 regulation of astrocyte activation | TAS PMID:29702085 TNF-Ξ±-sensitive brain pericytes activate microglia by releas... | KEEP AS NON CORE | Summary: Regulation of astrocyte activation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (regulation of astrocyte activation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0070050 neuron cellular homeostasis | TAS PMID:29702085 TNF-Ξ±-sensitive brain pericytes activate microglia by releas... | KEEP AS NON CORE | Summary: Neuron cellular homeostasis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (neuron cellular homeostasis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0070091 glucagon secretion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Glucagon secretion. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (glucagon secretion); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0070092 regulation of glucagon secretion | IDA PMID:22037645 Interleukin-6 enhances insulin secretion by increasing gluca... | KEEP AS NON CORE | Summary: Regulation of glucagon secretion. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (regulation of glucagon secretion); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0070102 interleukin-6-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:11884403 Shedding of the interleukin-6 (IL-6) receptor (gp80) determi... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:12829785 Hexameric structure and assembly of the interleukin-6/IL-6 a... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:16946298 STAT3 mediates hepatic hepcidin expression and its inflammat... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:27893700 Trans-presentation of IL-6 by dendritic cells is required fo... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:30670152 Regulation of IL-6 signaling by miR-125a and let-7e in endot... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:31101051 Response to IL-6 trans- and IL-6 classic signalling is deter... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:31145836 Physical proximity and functional cooperation of glycoprotei... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:7749983 Cross-linking of OX40 ligand, a member of the TNF/NGF cytoki... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | IMP PMID:28433754 miR-146a suppresses STAT3/VEGF pathways and reduces apoptosi... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070102 interleukin-6-mediated signaling pathway | NAS PMID:37069261 Targeting IL-6 trans-signalling: past, present and future pr... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway. Reason: The core pathway IL6 initiates through IL6R/gp130. Supporting Evidence: file:human/IL6/IL6-uniprot.txt complex associates to the signaling subunit IL6ST/gp130 to trigger the |
| GO:0070301 cellular response to hydrogen peroxide | IDA PMID:19168699 IL-6 protects against hyperoxia-induced mitochondrial damage... | KEEP AS NON CORE | Summary: Cellular response to hydrogen peroxide. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (cellular response to hydrogen peroxide); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0070345 negative regulation of fat cell proliferation | NAS PMID:31980524 Regulation of adipose tissue inflammation by interleukin 6. | KEEP AS NON CORE | Summary: Negative regulation of fat cell proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of fat cell proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0071222 cellular response to lipopolysaccharide | IMP PMID:23776175 SASH1 is a scaffold molecule in endothelial TLR4 signaling. | KEEP AS NON CORE | Summary: Cellular response to lipopolysaccharide. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (cellular response to lipopolysaccharide); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0072540 T-helper 17 cell lineage commitment | IDA PMID:27893700 Trans-presentation of IL-6 by dendritic cells is required fo... | KEEP AS NON CORE | Summary: T-helper 17 cell lineage commitment. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (T-helper 17 cell lineage commitment); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0072540 T-helper 17 cell lineage commitment | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: T-helper 17 cell lineage commitment. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (T-helper 17 cell lineage commitment); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0072574 hepatocyte proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Hepatocyte proliferation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (hepatocyte proliferation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0090091 positive regulation of extracellular matrix disassembly | IMP PMID:26587789 Dysregulated miR-98 Contributes to Extracellular Matrix Degr... | KEEP AS NON CORE | Summary: Positive regulation of extracellular matrix disassembly. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of extracellular matrix disassembly); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0090594 inflammatory response to wounding | IDA PMID:27830702 Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-... | KEEP AS NON CORE | Summary: Inflammatory response to wounding. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (inflammatory response to wounding); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0097421 liver regeneration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Liver regeneration. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (liver regeneration); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0097696 cell surface receptor signaling pathway via STAT | IDA PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK... | KEEP AS NON CORE | Summary: Cell surface receptor signaling via STAT. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (cell surface receptor signaling via STAT); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0097696 cell surface receptor signaling pathway via STAT | IDA PMID:12643274 Signaling of human ciliary neurotrophic factor (CNTF) revisi... | KEEP AS NON CORE | Summary: Cell surface receptor signaling via STAT. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (cell surface receptor signaling via STAT); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0097696 cell surface receptor signaling pathway via STAT | IDA PMID:19390056 Interleukin-6 modulates the expression of the bone morphogen... | KEEP AS NON CORE | Summary: Cell surface receptor signaling via STAT. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (cell surface receptor signaling via STAT); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0097696 cell surface receptor signaling pathway via STAT | IMP PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | KEEP AS NON CORE | Summary: Cell surface receptor signaling via STAT. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (cell surface receptor signaling via STAT); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0098586 cellular response to virus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Cellular response to virus. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (cellular response to virus); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0150077 regulation of neuroinflammatory response | TAS PMID:29702085 TNF-Ξ±-sensitive brain pericytes activate microglia by releas... | KEEP AS NON CORE | Summary: Regulation of neuroinflammatory response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (regulation of neuroinflammatory response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:0150078 positive regulation of neuroinflammatory response | TAS PMID:26753638 Role of TNF in mast cell neuroinflammation and pain. | KEEP AS NON CORE | Summary: Positive regulation of neuroinflammatory response. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of neuroinflammatory response); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:1900017 positive regulation of cytokine production involved in inflammatory response | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | KEEP AS NON CORE | Summary: Positive regulation of inflammatory cytokine production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of inflammatory cytokine production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:1901731 positive regulation of platelet aggregation | IDA PMID:31145836 Physical proximity and functional cooperation of glycoprotei... | KEEP AS NON CORE | Summary: Positive regulation of platelet aggregation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of platelet aggregation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:1902512 positive regulation of apoptotic DNA fragmentation | IMP PMID:28433754 miR-146a suppresses STAT3/VEGF pathways and reduces apoptosi... | KEEP AS NON CORE | Summary: Positive regulation of apoptotic DNA fragmentation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of apoptotic DNA fragmentation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:1902895 positive regulation of miRNA transcription | IDA PMID:19390056 Interleukin-6 modulates the expression of the bone morphogen... | KEEP AS NON CORE | Summary: Positive regulation of miRNA transcription. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of miRNA transcription); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:1903978 regulation of microglial cell activation | TAS PMID:29702085 TNF-Ξ±-sensitive brain pericytes activate microglia by releas... | KEEP AS NON CORE | Summary: Regulation of microglial cell activation. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (regulation of microglial cell activation); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:1904894 positive regulation of receptor signaling pathway via STAT | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Positive regulation of STAT signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of STAT signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:1904894 positive regulation of receptor signaling pathway via STAT | IGI PMID:30670152 Regulation of IL-6 signaling by miR-125a and let-7e in endot... | KEEP AS NON CORE | Summary: Positive regulation of STAT signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of STAT signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell | IDA PMID:30670152 Regulation of IL-6 signaling by miR-125a and let-7e in endot... | KEEP AS NON CORE | Summary: Positive regulation of leukocyte adhesion to endothelium. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of leukocyte adhesion to endothelium); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:2000553 positive regulation of T-helper 2 cell cytokine production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of Th2 cytokine production. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of Th2 cytokine production); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:2000635 negative regulation of primary miRNA processing | IGI PMID:31507089 Reciprocal regulation of miR-206 and IL-6/STAT3 pathway medi... | KEEP AS NON CORE | Summary: Negative regulation of primary miRNA processing. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of primary miRNA processing); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:2000660 negative regulation of interleukin-1-mediated signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of IL-1-mediated signaling. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (negative regulation of IL-1-mediated signaling); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
| GO:2000676 positive regulation of type B pancreatic cell apoptotic process | TAS PMID:18719127 Interleukin-6 regulates pancreatic alpha-cell mass expansion... | KEEP AS NON CORE | Summary: Positive regulation of pancreatic beta cell apoptosis. Reason: A pleiotropic downstream effect of IL6/gp130/JAK-STAT signaling (positive regulation of pancreatic beta cell apoptosis); genuine but non-core relative to IL6 cytokine/receptor-binding activity. Supporting Evidence: file:human/IL6/IL6-uniprot.txt Cytokine with a wide variety of biological functions in |
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Download this section (compressed HTML)Q: How do classic, trans- and cluster IL6 signaling modes differ in their biological outputs and contributions to disease?
Q: Which IL6 downstream programs depend on STAT3 versus MAPK/PI3K branches of gp130 signaling?
Experiment: Selective blockade of membrane IL6R versus soluble IL6R (e.g. olamkicept-type traps) with transcriptomic readouts to separate classic from trans-signaling outputs.
Type: pharmacology
Experiment: gp130 pathway-biased mutants to dissect STAT3- versus SHP2/MAPK-dependent IL6 responses in hepatocytes and immune cells.
Type: cell biology
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