Pathway Summary for INTU

Overview

INTU (Inturned planar cell polarity protein) is a core component of the planar cell polarity (PCP) pathway that regulates ciliogenesis and directional cell movements. It functions in the CPLANE (ciliogenesis and planar polarity effector) complex, controlling primary cilium formation and establishing tissue polarity.

Core Pathways

Planar Cell Polarity Signaling

INTU participates in non-canonical Wnt/PCP signaling:
- Asymmetric protein localization
- Convergent extension movements
- Directional cell migration
- Tissue patterning

Ciliogenesis Regulation

INTU controls primary cilium assembly through:
- CPLANE complex formation
- IFT-A complex recruitment
- Basal body docking
- Ciliary vesicle formation

Pathway Diagram

graph TD A[Wnt/PCP Signals] --> B[INTU: PCP Effector] B --> C[CPLANE Complex] C --> D[Ciliogenesis] B --> E[Cell Polarity] E --> F[Directional Movement] C --> G[IFT-A Recruitment] G --> D H[DVL] --> B I[VANGL] --> B style B fill:#f9f,stroke:#333,stroke-width:2px

Clinical Significance

Ciliopathies: INTU mutations cause skeletal ciliopathies
Neural tube defects: Disrupted convergent extension
Short-rib polydactyly syndrome: Skeletal abnormalities