IP6K3

UniProt ID: Q96PC2
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for IP6K3

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005634 nucleus
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046854 phosphatidylinositol phosphate biosynthetic process
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000828 inositol hexakisphosphate kinase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032958 inositol phosphate biosynthetic process
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000166 nucleotide binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000828 inositol hexakisphosphate kinase activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000829 diphosphoinositol pentakisphosphate kinase activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000832 inositol hexakisphosphate 5-kinase activity
IEA
GO_REF:0000116 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005524 ATP binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016301 kinase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016740 transferase activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032958 inositol phosphate biosynthetic process
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043647 inositol phosphate metabolic process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046488 phosphatidylinositol metabolic process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0052839 diphosphoinositol tetrakisphosphate kinase activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090407 organophosphate biosynthetic process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32296183
Apr 8. A reference map of the human binary protein interactome.
GO:0005634 nucleus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043647 inositol phosphate metabolic process
TAS
Reactome:R-HSA-1855167 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000828 inositol hexakisphosphate kinase activity
TAS
Reactome:R-HSA-1855227 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000829 diphosphoinositol pentakisphosphate kinase activity
TAS
Reactome:R-HSA-1855194 		PENDING
Summary: TODO: Review this GOA annotation
GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity
TAS
Reactome:R-HSA-1855158 		PENDING
Summary: TODO: Review this GOA annotation
GO:0052839 diphosphoinositol tetrakisphosphate kinase activity
TAS
Reactome:R-HSA-1855193 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
TAS
Reactome:R-HSA-1855223 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000828 inositol hexakisphosphate kinase activity
IDA
PMID:11502751
Identification and characterization of a novel inositol hexa... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11502751
2001 Aug 13. Identification and characterization of a novel inositol hexakisphosphate kinase.
GO:0005829 cytosol
TAS
Reactome:R-HSA-1855158 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1855193 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1855194 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1855223 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1855227 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000831 inositol hexakisphosphate 6-kinase activity
IDA
PMID:11502751
Identification and characterization of a novel inositol hexa... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11502751
2001 Aug 13. Identification and characterization of a novel inositol hexakisphosphate kinase.
GO:0032958 inositol phosphate biosynthetic process
IDA
PMID:11502751
Identification and characterization of a novel inositol hexa... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11502751
2001 Aug 13. Identification and characterization of a novel inositol hexakisphosphate kinase.
GO:0006468 protein phosphorylation
IDA
PMID:11502751
Identification and characterization of a novel inositol hexa... 		REMOVE
Summary: MISANNOTATION: IP6K3 (Inositol hexakisphosphate kinase 3) is EC 2.7.4.21, an INOSITOL POLYPHOSPHATE kinase, NOT a protein kinase. Its catalytic activity is "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol" - it phosphorylates inositol polyphosphates, not proteins. PMID:11502751 title is "Identification and characterization of a novel inositol hexakisphosphate kinase" - no mention of protein phosphorylation.
Supporting Evidence:
PMID:11502751
2001 Aug 13. Identification and characterization of a novel inositol hexakisphosphate kinase.
GO:0046488 phosphatidylinositol metabolic process
IDA
PMID:11502751
Identification and characterization of a novel inositol hexa... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11502751
2001 Aug 13. Identification and characterization of a novel inositol hexakisphosphate kinase.
GO:0005737 cytoplasm
IDA
PMID:11502751
Identification and characterization of a novel inositol hexa... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11502751
2001 Aug 13. Identification and characterization of a novel inositol hexakisphosphate kinase.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000116
Automatic Gene Ontology annotation based on Rhea mapping
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:11502751
Identification and characterization of a novel inositol hexakisphosphate kinase.
PMID:32296183
A reference map of the human binary protein interactome.
Reactome:R-HSA-1855158
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
Reactome:R-HSA-1855167
Synthesis of pyrophosphates in the cytosol
Reactome:R-HSA-1855193
1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
Reactome:R-HSA-1855194
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
Reactome:R-HSA-1855223
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
Reactome:R-HSA-1855227
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol

📄 View Raw YAML

 
id: Q96PC2
gene_symbol: IP6K3
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for IP6K3'
existing_annotations:
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046854
      label: phosphatidylinositol phosphate biosynthetic process
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000828
      label: inositol hexakisphosphate kinase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032958
      label: inositol phosphate biosynthetic process
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000166
      label: nucleotide binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000827
      label: inositol-1,3,4,5,6-pentakisphosphate kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000828
      label: inositol hexakisphosphate kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000829
      label: diphosphoinositol pentakisphosphate kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000832
      label: inositol hexakisphosphate 5-kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000116
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005524
      label: ATP binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016301
      label: kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016740
      label: transferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032958
      label: inositol phosphate biosynthetic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043647
      label: inositol phosphate metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046488
      label: phosphatidylinositol metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0052836
      label: inositol 5-diphosphate pentakisphosphate 5-kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0052839
      label: diphosphoinositol tetrakisphosphate kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090407
      label: organophosphate biosynthetic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043647
      label: inositol phosphate metabolic process
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855167
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000828
      label: inositol hexakisphosphate kinase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855227
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000829
      label: diphosphoinositol pentakisphosphate kinase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855194
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0052836
      label: inositol 5-diphosphate pentakisphosphate 5-kinase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855158
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0052839
      label: diphosphoinositol tetrakisphosphate kinase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855193
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000827
      label: inositol-1,3,4,5,6-pentakisphosphate kinase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855223
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000828
      label: inositol hexakisphosphate kinase activity
    evidence_type: IDA
    original_reference_id: PMID:11502751
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11502751
          supporting_text: 2001 Aug 13. Identification and characterization of a
            novel inositol hexakisphosphate kinase.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855158
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855193
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855194
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855223
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1855227
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000831
      label: inositol hexakisphosphate 6-kinase activity
    evidence_type: IDA
    original_reference_id: PMID:11502751
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11502751
          supporting_text: 2001 Aug 13. Identification and characterization of a
            novel inositol hexakisphosphate kinase.
  - term:
      id: GO:0032958
      label: inositol phosphate biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:11502751
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11502751
          supporting_text: 2001 Aug 13. Identification and characterization of a
            novel inositol hexakisphosphate kinase.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:11502751
    review:
      summary: >-
        MISANNOTATION: IP6K3 (Inositol hexakisphosphate kinase 3) is EC 2.7.4.21,
        an INOSITOL POLYPHOSPHATE kinase, NOT a protein kinase. Its catalytic activity
        is "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol"
        - it
        phosphorylates inositol polyphosphates, not proteins. PMID:11502751 title
        is
        "Identification and characterization of a novel inositol hexakisphosphate
        kinase"
        - no mention of protein phosphorylation.
      action: REMOVE
      supported_by:
        - reference_id: PMID:11502751
          supporting_text: 2001 Aug 13. Identification and characterization of a
            novel inositol hexakisphosphate kinase.
  - term:
      id: GO:0046488
      label: phosphatidylinositol metabolic process
    evidence_type: IDA
    original_reference_id: PMID:11502751
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11502751
          supporting_text: 2001 Aug 13. Identification and characterization of a
            novel inositol hexakisphosphate kinase.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:11502751
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11502751
          supporting_text: 2001 Aug 13. Identification and characterization of a
            novel inositol hexakisphosphate kinase.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000116
    title: Automatic Gene Ontology annotation based on Rhea mapping
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:11502751
    title: Identification and characterization of a novel inositol 
      hexakisphosphate kinase.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: Reactome:R-HSA-1855158
    title: 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
    findings: []
  - id: Reactome:R-HSA-1855167
    title: Synthesis of pyrophosphates in the cytosol
    findings: []
  - id: Reactome:R-HSA-1855193
    title: 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
    findings: []
  - id: Reactome:R-HSA-1855194
    title: 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
    findings: []
  - id: Reactome:R-HSA-1855223
    title: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the 
      cytosol
    findings: []
  - id: Reactome:R-HSA-1855227
    title: IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
    findings: []