Integrin beta-1 (CD29) is a single-pass type I transmembrane glycoprotein that forms non-covalent heterodimers with twelve integrin alpha subunits (alpha1-alpha11 and alphaV), making beta1 integrins the largest integrin subfamily. The heterodimers are cell adhesion receptors for extracellular matrix proteins: collagens (alpha1, alpha2, alpha10, alpha11 beta1), laminins (alpha3, alpha6, alpha7 beta1), fibronectin (alpha5beta1 above all, also alpha4, alpha8 and alphaV beta1) and fibrillin-1, and for cell-surface counter-receptors such as VCAM1 (alpha4beta1, alpha9beta1). Ligand binding at the alpha/beta head depends on divalent cations held at the MIDAS, ADMIDAS and SyMBS sites of the beta1 betaI domain. The short cytoplasmic tail, with its NPxY motifs, binds talin, kindlin, filamin, ICAP-1 and kinases such as FAK and Abl2, coupling the receptor to the actin cytoskeleton at focal adhesions and allowing bidirectional (inside-out activation and outside-in) signalling. Beta1 integrins are endocytosed and recycled to the leading edge, support cell spreading and migration, and act in many tissue-level processes including angiogenesis, leukocyte adhesion, myogenesis (the muscle isoform beta1D at costameres) and osteoclast function; several viruses and microbes use beta1 integrins as entry receptors. Integrin beta subunits predate animals: the unicellular holozoan Capsaspora owczarzaki has four integrin beta genes with conserved cation-binding sites and NPxY motifs, and it adheres to substrate through actin-rich filopodia in which integrin beta2 and vinculin form patches, whereas choanoflagellates have lost integrins.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000132 establishment of mitotic spindle orientation | IMP PMID:30992345 Connexin 43 maintains tissue polarity and regulates mitotic ... | KEEP AS NON CORE | Summary: IMP annotation of ITGB1 to establishment of mitotic spindle orientation (GO:0000132) from PMID:30992345. Reason: In 3D breast acini, combined gap-junction and beta1 inhibition alters mitotic spindle orientation; beta1 adhesion to basement membrane orients the spindle in epithelia. Tissue-level, animal-specific role. Supporting Evidence: PMID:30992345 Since Ξ²1-integrin participates in mammary acinar development ( Berdichevsky et al., 1994 ), we investigated the potential role of this adhesion molecule in regulating MSO in the breast epithelium. |
| GO:0000287 magnesium ion binding | IDA PMID:33962943 Structural insights into integrin Ξ±(5)Ξ²(1) opening by fibron... | ACCEPT | Summary: IDA annotation of ITGB1 to magnesium ion binding (GO:0000287) from PMID:33962943. Reason: Magnesium binding at the MIDAS of the beta1 betaI domain is resolved in the native alpha5beta1 cryo-EM structure; Mg2+ at MIDAS coordinates the ligand Asp of RGD. The MIDAS/ADMIDAS cation-binding motifs are conserved in non-metazoan integrin beta subunits, so this is an ancestral biochemical property. Supporting Evidence: PMID:33962943 The integrin Ξ²I domain contains three functional metal ion pockets exhibiting clear densities, namely, MIDAS, ADMIDAS PMID:20479219 are well conserved in the different nonmetazoan integrin Ξ², except for C. owczarzaki integrin Ξ²4 |
| GO:0001525 angiogenesis | IDA PMID:29763414 CD93 promotes Ξ²1 integrin activation and fibronectin fibrill... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to angiogenesis (GO:0001525) from PMID:29763414. Reason: CD93 is required for full beta1 integrin activation and fibronectin fibrillogenesis in tumour endothelium; beta1 integrins take part in angiogenesis as the endothelial matrix receptor. This is a tissue-level, animal-specific role, not the core activity. Supporting Evidence: PMID:29763414 CD93 colocalizes with activated Ξ²1 integrin chain in endothelial cells, and is required for full Ξ²1 integrin activation and fibronectin fibrillogenesis in vitro. |
| GO:0001525 angiogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to angiogenesis (GO:0001525) from GO_REF:0000117; with/from ARBA:ARBA00090097. Reason: ARBA prediction consistent with the IDA evidence (PMID:29763414) that beta1 integrin acts in endothelial sprouting; kept as a non-core, animal-specific process. Supporting Evidence: PMID:29763414 CD93 colocalizes with activated Ξ²1 integrin chain in endothelial cells, and is required for full Ξ²1 integrin activation and fibronectin fibrillogenesis in vitro. |
| GO:0001726 ruffle | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to ruffle (GO:0001726) from GO_REF:0000117; with/from ARBA:ARBA00089602. Reason: Beta1 integrins are present in ruffles and lamellipodia of spreading cells (nascent adhesions), but focal adhesions are the main site. Kept as non-core. Supporting Evidence: PMID:11919189 These adhesion sites are enriched in occupied beta(1) integrins and precede the formation of focal adhesions devoid of ICAP-1alpha and nm23-H2 |
| GO:0001726 ruffle | TAS PMID:11919189 Integrin cytoplasmic domain-associated protein 1alpha (ICAP-... | KEEP AS NON CORE | Summary: TAS annotation of ITGB1 to ruffle (GO:0001726) from PMID:11919189. Reason: The cited paper places occupied beta1 integrins with ICAP-1alpha at lamellipodial adhesion sites at the cell periphery during spreading. Ruffle localization is real but secondary to focal adhesions. Supporting Evidence: PMID:11919189 These adhesion sites are enriched in occupied beta(1) integrins and precede the formation of focal adhesions devoid of ICAP-1alpha and nm23-H2 |
| GO:0001968 fibronectin binding | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to fibronectin binding (GO:0001968) from GO_REF:0000033; with/from PANTHER:PTN002560762, RGD:2927, UniProtKB:P05556, ZFIN:ZDB-GENE-060803-2. Reason: PAINT placed fibronectin binding on the beta1 node (PTN002560762) seeded with human, rat and zebrafish beta1 experimental data; alpha5beta1, alpha4beta1, alpha8beta1 and alphaVbeta1 are fibronectin receptors. Ligand binding is shared with the alpha subunit, but the beta1 betaI domain contributes directly (ADMIDAS contact). Supporting Evidence: PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. PMID:33962943 key interactions centered at R1445 and Y1446 of FN and D137 of ADMIDAS in Ξ²1 Ξ²I domain provide an additional anchoring point that triggers the opening of Ξ±5Ξ²1 |
| GO:0001968 fibronectin binding | IDA PMID:26763945 Focal Adhesion Kinase Regulates Fibroblast Migration via Int... | ACCEPT | Summary: IDA annotation of ITGB1 to fibronectin binding (GO:0001968) from PMID:26763945. Reason: FAK-dependent fibroblast migration on fibronectin relies on integrin beta1 as the fibronectin receptor; fibronectin binding is a core beta1 activity. Supporting Evidence: PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0001968 fibronectin binding | IEA GO_REF:0000117 | ACCEPT | Summary: IEA annotation of ITGB1 to fibronectin binding (GO:0001968) from GO_REF:0000117; with/from ARBA:ARBA00091264. Reason: ARBA prediction agrees with the experimental and structural evidence that beta1 integrins (alpha5beta1 above all) bind fibronectin. Supporting Evidence: PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0001968 fibronectin binding | IPI PMID:11792823 Fibulin-1 suppression of fibronectin-regulated cell adhesion... | ACCEPT | Summary: IPI annotation of ITGB1 to fibronectin binding (GO:0001968) from PMID:11792823; with/from UniProtKB:P02751. Reason: IPI with fibronectin (P02751) in a fibulin-1 study of fibronectin-dependent adhesion; the paper tested alpha5beta1-fibronectin interactions. Consistent with the structural evidence for fibronectin binding by alpha5beta1. Supporting Evidence: PMID:11792823 the mechanism for the motility-suppressive effects of fibulin-1 does not involve perturbations of interactions between alpha5beta1 or alpha4 integrins, or heparan sulfate proteoglycans with FN PMID:33962943 key interactions centered at R1445 and Y1446 of FN and D137 of ADMIDAS in Ξ²1 Ξ²I domain provide an additional anchoring point that triggers the opening of Ξ±5Ξ²1 |
| GO:0002020 protease binding | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to protease binding (GO:0002020) from GO_REF:0000117; with/from ARBA:ARBA00087861. Reason: ARBA prediction; consistent with alpha3beta1 docking of seprase/FAP and alpha5beta1 binding of ADAM disintegrin domains. Real but not core. Supporting Evidence: PMID:10455171 The results show that alpha(3)beta(1) integrin is a docking protein for seprase to form functional invadopodia. |
| GO:0002020 protease binding | IPI PMID:10455171 A novel protease-docking function of integrin at invadopodia... | KEEP AS NON CORE | Summary: IPI annotation of ITGB1 to protease binding (GO:0002020) from PMID:10455171; with/from UniProtKB:Q12884. Reason: Collagen induces association of alpha3beta1 with seprase (FAP, Q12884) on invadopodia; the integrin docks the protease. A specialised, non-core activity. Supporting Evidence: PMID:10455171 The results show that alpha(3)beta(1) integrin is a docking protein for seprase to form functional invadopodia. |
| GO:0003779 actin binding | IDA PMID:16803572 Role of dystrophins and utrophins in platelet adhesion proce... | UNDECIDED | Summary: IDA annotation of ITGB1 to actin binding (GO:0003779) from PMID:16803572. Reason: The cached abstract reports co-immunoprecipitation and immunofluorescence of a beta1 integrin fraction with dystrophin/utrophin complexes and focal adhesion proteins in platelets; it does not show direct actin binding by beta1. Beta1 reaches actin through talin, filamin and other adaptors. Without the full text the basis for direct actin binding cannot be assessed, so the experimental row is left undecided rather than removed. Supporting Evidence: PMID:16803572 their potential association with integrin beta-1 fraction and the focal adhesion system (alpha-actinin, vinculin and talin) was evaluated by immunofluorescence and immunoprecipitation assays PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0004895 cell adhesion receptor activity | IDA PMID:10655584 Activation of EphA2 kinase suppresses integrin function and ... | ACCEPT | Summary: IDA annotation of ITGB1 to cell adhesion receptor activity (GO:0004895) from PMID:10655584. Reason: Cell adhesion receptor activity (binding ECM to mediate adhesion) is the core molecular function of beta1 integrins. The paper shows integrin adhesive function is switched off by EphA2 through an inactive integrin conformation; the same activity is used in the EPHA2 GO-CAM (689e7a5d00003515). Supporting Evidence: PMID:10655584 activation of endogenous EphA2 kinase induces an inactive conformation of integrins and inhibits cell spreading, migration and integrin-mediated adhesion PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. |
| GO:0005178 integrin binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation of ITGB1 to integrin binding (GO:0005178) from GO_REF:0000033; with/from MGI:MGI:96610, MGI:MGI:96612, MGI:MGI:96614, MGI:MGI:96615. Reason: PAINT IBA for integrin binding across the integrin beta family. For beta1 the 'integrin' partner is its own alpha subunits (heterodimer assembly), which is better captured by the integrin complex CC terms; kept as a valid but non-core MF. Supporting Evidence: PMID:2649503 VLA-6 is a typical integrin heterodimer, with alpha 6-beta 1 subunit association |
| GO:0005178 integrin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to integrin binding (GO:0005178) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl Compara transfer from mouse Itgb1. Beta1 binds integrin alpha subunits (heterodimer partners); valid but redundant with complex membership, so non-core. Supporting Evidence: PMID:2649503 VLA-6 is a typical integrin heterodimer, with alpha 6-beta 1 subunit association |
| GO:0005178 integrin binding | TAS PMID:8020569 Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2)... | KEEP AS NON CORE | Summary: TAS annotation of ITGB1 to integrin binding (GO:0005178) from PMID:8020569. Reason: The cited paper studies alpha4/beta1 (VLA-4) and alpha5/beta1 mRNA regulation in myeloid differentiation; it supports beta1 pairing with alpha subunits (alpha4beta1, alpha5beta1) rather than a separate binding function. Kept as non-core. Supporting Evidence: PMID:8020569 Integrins are a family of cell surface heterodimers which mediate both cell-cell and cell-extracellular matrix interactions |
| GO:0005509 calcium ion binding | IDA PMID:33962943 Structural insights into integrin Ξ±(5)Ξ²(1) opening by fibron... | ACCEPT | Summary: IDA annotation of ITGB1 to calcium ion binding (GO:0005509) from PMID:33962943. Reason: Calcium binding at the ADMIDAS and SyMBS/LIMBS sites of the beta1 betaI domain is resolved in the native alpha5beta1 cryo-EM structure; ADMIDAS D137 contacts fibronectin. Integrin beta also binds Ca2+ via its EGF/PSI region, but the betaI sites are the functional ones. Supporting Evidence: PMID:33962943 The integrin Ξ²I domain contains three functional metal ion pockets exhibiting clear densities, namely, MIDAS, ADMIDAS PMID:33962943 key interactions centered at R1445 and Y1446 of FN and D137 of ADMIDAS in Ξ²1 Ξ²I domain provide an additional anchoring point that triggers the opening of Ξ±5Ξ²1 |
| GO:0005515 protein binding | IPI PMID:10397731 Thrombospondin-1 acts via IAP/CD47 to synergize with collage... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:10397731; with/from UniProtKB:P17301. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA2 (P17301): the paper co-precipitates CD47 (IAP) with alpha2beta1; alpha2-beta1 pairing is captured by the integrin alpha2-beta1 complex row. |
| GO:0005515 protein binding | IPI PMID:10676904 Effect of medium change on the development of in vitro matur... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:10676904; with/from UniProtKB:O75369. Reason: Generic protein binding is uninformative; the partner is filamin-B (O75369), so filamin binding is the informative term, as for the other filamin rows in this review. The cited PMID:10676904 is a bovine oocyte culture paper (J Vet Med Sci 2000), so it cannot support the row; the intended paper is almost certainly PMID:16076904, a transposition of the second and third digits. That paper reports filamin binding to the beta1A subunit, UniProt cites it for the ITGB1-FLNB and ITGB1-FLNC interactions, and GOA's ITGB1-FLNC row from the same UniProt curation date (2006-03-16) cites it correctly. See the PMID:10676904 reference_review. Proposed replacements: filamin binding Supporting Evidence: PMID:16076904 binding activity with the beta1A integrin subunit. PMID:9722563 the cytoplasmic domain of beta1-integrin specifically interacts with the cytoskeletal protein filamin |
| GO:0005515 protein binding | IPI PMID:11279249 Conformation, localization, and integrin binding of talin de... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:11279249; with/from UniProtKB:Q9Y490. Reason: Generic protein binding is uninformative; the partner is talin-1 (Q9Y490) and the paper studies PI(4,5)P2-dependent talin binding to the integrin tail. Talin binding is the informative term. Proposed replacements: talin binding Supporting Evidence: PMID:11279249 the interaction between integrin and talin was greatly enhanced by PI4,5P(2)-induced talin activation |
| GO:0005515 protein binding | IPI PMID:11807099 The integrin cytoplasmic domain-associated protein ICAP-1 bi... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:11807099; with/from UniProtKB:O14713. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ICAP-1 (ITGB1BP1, O14713); ICAP-1 binds the beta1A tail NPXY region and regulates Rho GTPases. GO has no ICAP-1-binding term and no more specific beta1 MF follows. Supporting Evidence: PMID:11807099 Using two-hybrid screening, we isolated the integrin cytoplasmic domain-associated protein (ICAP-1), an interactor for the COOH terminal region of the beta1A integrin cytoplasmic domain. |
| GO:0005515 protein binding | IPI PMID:12473654 Disruption of focal adhesions by integrin cytoplasmic domain... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:12473654; with/from UniProtKB:O14713. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ICAP-1 (ITGB1BP1); the interaction is real and makes ICAP-1 a negative regulator of beta1 avidity, but no specific beta1 MF term follows. Supporting Evidence: PMID:12473654 ICAP-1 alpha to inhibit the association of beta(1A) integrin with talin, which is crucial for the assembly of these structures |
| GO:0005515 protein binding | IPI PMID:12473654 Disruption of focal adhesions by integrin cytoplasmic domain... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:12473654; with/from UniProtKB:Q9Y490. Reason: Generic protein binding is uninformative; the partner is talin-1 (Q9Y490); ICAP-1 competes with talin for the beta1A tail. Talin binding is the informative term. Proposed replacements: talin binding Supporting Evidence: PMID:12473654 ICAP-1 alpha to inhibit the association of beta(1A) integrin with talin, which is crucial for the assembly of these structures |
| GO:0005515 protein binding | IPI PMID:12500944 The integrin beta1 subunit cytoplasmic tail forms oligomers:... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:12500944; with/from UniProtKB:P05556. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Self-interaction of synthetic beta1 cytoplasmic peptides in vitro (SPR, size exclusion); a possible role in clustering is proposed but not shown for the full-length receptor. Supporting Evidence: PMID:12500944 Direct protein-protein interaction studies by surface plasmon resonance demonstrate that integrin beta1 cytoplasmic peptides self-associate in contrast to integrin beta3 cytoplasmic tails. |
| GO:0005515 protein binding | IPI PMID:12592401 Epstein-Barr virus infection of polarized tongue and nasopha... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:12592401; with/from UniProtKB:P03192. Reason: Generic protein binding is uninformative; the partner is Epstein-Barr virus BMRF-2 (P03192) and the interaction mediates virion entry through basolateral membranes. Virus receptor activity is the informative term. Proposed replacements: virus receptor activity Supporting Evidence: PMID:12592401 mediated in part through an interaction between beta1 or alpha5beta1 integrins and the EBV BMRF-2 protein |
| GO:0005515 protein binding | IPI PMID:12695522 CCN3 (NOV) is a novel angiogenic regulator of the CCN protei... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:12695522; with/from UniProtKB:P48745. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner CCN3 (P48745), a matricellular ligand that binds alpha5beta1 and alphavbeta3; the receptor role is covered by cell adhesion receptor activity. Supporting Evidence: PMID:12695522 these findings show that CCN3 is a ligand of integrins alphavbeta3 and alpha5beta1 |
| GO:0005515 protein binding | IPI PMID:12724312 Ganglioside GM3 inhibits matrix metalloproteinase-9 activati... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:12724312; with/from UniProtKB:P08648. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA5 (P08648); the paper is about MMP-9 association with alpha5beta1; subunit pairing is captured by the integrin alpha5-beta1 complex rows. |
| GO:0005515 protein binding | IPI PMID:12796480 Tetraspanins CD9 and CD81 function to prevent the fusion of ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:12796480; with/from UniProtKB:P21926. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner CD9 (P21926); tetraspanin-integrin complexes in mononuclear phagocyte fusion. No specific beta1 MF follows. Supporting Evidence: PMID:12796480 Among integrins, the Ξ²1 subfamily most commonly associates with tetraspanins |
| GO:0005515 protein binding | IPI PMID:12807887 Cell adhesion to fibrillin-1 molecules and microfibrils is m... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:12807887; with/from UniProtKB:P35555. Reason: Generic protein binding is uninformative; the partner is fibrillin-1 (P35555), an extracellular matrix microfibril protein, and alpha5beta1 is a fibrillin-1 receptor. GO has no fibrillin-binding term, so extracellular matrix binding is used. Proposed replacements: extracellular matrix binding Supporting Evidence: PMID:12807887 alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors |
| GO:0005515 protein binding | IPI PMID:14681217 Involvement of transmembrane domain interactions in signal t... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:14681217; with/from UniProtKB:P13612. Reason: Generic protein binding is uninformative; the paper measures alpha/beta transmembrane helix association (partner ITGA4, P13612) and concludes that the TM helices stabilise the heterodimer. Protein heterodimerization activity describes this. Proposed replacements: protein heterodimerization activity Supporting Evidence: PMID:14681217 Our data suggest that the integrin transmembrane helices can help to stabilize heterodimeric integrins |
| GO:0005515 protein binding | IPI PMID:14681217 Involvement of transmembrane domain interactions in signal t... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:14681217; with/from UniProtKB:P17301. Reason: Generic protein binding is uninformative; as for the ITGA4 row from the same paper, with ITGA2 (P17301) as partner: alpha/beta transmembrane helix heterodimerization. Proposed replacements: protein heterodimerization activity Supporting Evidence: PMID:14681217 Our data suggest that the integrin transmembrane helices can help to stabilize heterodimeric integrins |
| GO:0005515 protein binding | IPI PMID:14970227 Integrin alpha5beta1 and ADAM-17 interact in vitro and co-lo... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:14970227; with/from UniProtKB:P78536. Reason: Generic protein binding is uninformative; the partner ADAM17 (P78536) binds alpha5beta1 through its disintegrin/cysteine-rich region as a ligand; protease binding is the informative term already used for seprase docking. Proposed replacements: protease binding Supporting Evidence: PMID:14970227 the two molecules appear to have a ligand-receptor relationship mediated by the alpha(5)beta(1) ligand binding pocket |
| GO:0005515 protein binding | IPI PMID:15289498 Selective modulation of type 1 insulin-like growth factor re... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:15289498; with/from UniProtKB:P08069. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner IGF1R (P08069); beta1A forms a complex with IGF-IR and IRS-1 that modulates IGF signalling. No specific beta1 MF term follows. Supporting Evidence: PMID:15289498 The beta1A integrin forms a complex with the IGF-IR and insulin receptor substrate-1 (IRS-1) |
| GO:0005515 protein binding | IPI PMID:1542691 A family of beta 7 integrins on human mucosal lymphocytes. | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:1542691; with/from UniProtKB:P13612. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA4 (P13612); the paper defines beta7 integrins and notes alpha4 pairing; alpha4-beta1 pairing is captured by the integrin alpha4-beta1 complex rows. |
| GO:0005515 protein binding | IPI PMID:15466886 alpha4beta1- and alpha6beta1-integrins are functional recept... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:15466886; with/from UniProtKB:O88572. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner mouse LRP6 (O88572), co-precipitated with alpha6beta1/alpha4beta1 in a midkine receptor study; no specific beta1 MF follows. Supporting Evidence: PMID:15466886 We observed that the low-density-lipoprotein-receptor-related-protein-6 ectodomain was immunoprecipitated with alpha6beta1-integrin and alpha4beta1-integrin. |
| GO:0005515 protein binding | IPI PMID:15466886 alpha4beta1- and alpha6beta1-integrins are functional recept... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:15466886; with/from UniProtKB:P13612, UniProtKB:P21741. Reason: Generic protein binding is uninformative; the row records binding of alpha4beta1 (ITGA4 with midkine, P21741) and the paper concludes alpha4beta1 and alpha6beta1 are functional midkine receptors (midkine-dependent migration and paxillin phosphorylation). Signaling receptor activity is the informative term. Proposed replacements: signaling receptor activity Supporting Evidence: PMID:15466886 Therefore, we concluded that alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine. |
| GO:0005515 protein binding | IPI PMID:15466886 alpha4beta1- and alpha6beta1-integrins are functional recept... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:15466886; with/from UniProtKB:P13612, UniProtKB:P23229. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partners ITGA4 and ITGA6 from a midkine receptor study; subunit pairing is captured by the integrin complex rows. |
| GO:0005515 protein binding | IPI PMID:15466886 alpha4beta1- and alpha6beta1-integrins are functional recept... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:15466886; with/from UniProtKB:P21741. Reason: Generic protein binding is uninformative; partner midkine (P21741); alpha4beta1 and alpha6beta1 are functional midkine receptors. Signaling receptor activity is the informative term. Proposed replacements: signaling receptor activity Supporting Evidence: PMID:15466886 Therefore, we concluded that alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine. |
| GO:0005515 protein binding | IPI PMID:15466886 alpha4beta1- and alpha6beta1-integrins are functional recept... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:15466886; with/from UniProtKB:P21741, UniProtKB:P23229. Reason: Generic protein binding is uninformative; partners midkine (P21741) and ITGA6; alpha6beta1 is a functional midkine receptor. Signaling receptor activity is the informative term. Proposed replacements: signaling receptor activity Supporting Evidence: PMID:15466886 Therefore, we concluded that alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine. |
| GO:0005515 protein binding | IPI PMID:15466886 alpha4beta1- and alpha6beta1-integrins are functional recept... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:15466886; with/from UniProtKB:Q62656. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner rat PTPRZ1 (Q62656), another midkine receptor detected in the same multimolecular study; no specific beta1 MF follows. |
| GO:0005515 protein binding | IPI PMID:15703214 Nuclear translocation of integrin cytoplasmic domain-associa... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:15703214; with/from UniProtKB:O14713. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ICAP-1 (ITGB1BP1); the paper is about ICAP-1 nucleocytoplasmic shuttling regulated by beta1. No specific beta1 MF term follows. Supporting Evidence: PMID:15703214 ICAP-1 shuttles between the nucleus and cytoplasm in a beta1 integrin-dependent manner |
| GO:0005515 protein binding | IPI PMID:16076904 The Z-disc proteins myotilin and FATZ-1 interact with each o... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:16076904; with/from UniProtKB:Q14315. Reason: Generic protein binding is uninformative; the partner is filamin-C (Q14315), which links Z-disc proteins to beta1A integrin at the sarcolemma. Filamin binding is the informative term. Proposed replacements: filamin binding Supporting Evidence: PMID:16076904 provide evidence for a novel connection between Z-disc proteins and the sarcolemma via filamins and beta1 integrins |
| GO:0005515 protein binding | IPI PMID:16099422 Murine lipid phosphate phosphohydrolase-3 acts as a cell-ass... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:16099422; with/from UniProtKB:P08648. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA5 (P08648) in an LPP3 ligand study; alpha5-beta1 pairing is captured by the complex rows. |
| GO:0005515 protein binding | IPI PMID:16754661 Collagen XVI harbors an integrin alpha1 beta1 recognition si... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:16754661; with/from UniProtKB:Q07092. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner collagen XVI (Q07092); the abstract states both alpha1beta1 and alpha2beta1 bind collagen XVI through the alpha subunit A domain, so a collagen-binding MF should not be attached to beta1 from this paper. Collagen-receptor function of beta1 integrins is captured by the collagen binding rows. Supporting Evidence: PMID:16754661 Both integrins interact with collagen XVI via the A domain of their alpha subunits. |
| GO:0005515 protein binding | IPI PMID:16754960 Small GTPase Rab21 regulates cell adhesion and controls endo... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:16754960; with/from UniProtKB:P35282. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner mouse Rab21 (P35282). The paper places Rab21 (and Rab5) on the cytoplasmic domains of alpha-integrin chains, so small GTPase binding should not be attributed to beta1 from this paper. Supporting Evidence: PMID:16754960 Rab21 (and Rab5) associate with the cytoplasmic domains of alpha-integrin chains |
| GO:0005515 protein binding | IPI PMID:16803572 Role of dystrophins and utrophins in platelet adhesion proce... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:16803572; with/from UniProtKB:P46939. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner utrophin (P46939), co-immunoprecipitated with a beta1 fraction in platelets; no specific beta1 MF follows. Supporting Evidence: PMID:16803572 their potential association with integrin beta-1 fraction and the focal adhesion system (alpha-actinin, vinculin and talin) was evaluated by immunofluorescence and immunoprecipitation assays |
| GO:0005515 protein binding | IPI PMID:17158881 alphaVbeta6 is a novel receptor for human fibrillin-1. Compa... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:17158881; with/from UniProtKB:P35555. Reason: Generic protein binding is uninformative; the partner is fibrillin-1 (P35555); alpha5beta1 is a low-affinity fibrillin-1 receptor. GO has no fibrillin-binding term, so extracellular matrix binding is used. Proposed replacements: extracellular matrix binding Supporting Evidence: PMID:17158881 our data suggest alpha5beta1 is a low affinity fibrillin-1 receptor |
| GO:0005515 protein binding | IPI PMID:17690686 Structure of three tandem filamin domains reveals auto-inhib... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:17690686; with/from UniProtKB:P21333. Reason: Generic protein binding is uninformative; the partner is filamin A (P21333), and the paper measures FLNa binding to beta1A tails in pull-downs. Filamin binding is the informative term. Proposed replacements: filamin binding Supporting Evidence: PMID:17690686 GFP-FLNa (I2144E) displayed enhanced binding to Ξ²7 and Ξ²1A integrin tails in pull-down assays from cell lysates |
| GO:0005515 protein binding | IPI PMID:17704059 Role of ADAM-9 disintegrin-cysteine-rich domains in human ke... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:17704059; with/from UniProtKB:Q13443. Reason: Generic protein binding is uninformative; the partner ADAM9 (Q13443) disintegrin-cysteine-rich domain binds the beta1 subunit as an adhesive ligand. Protease binding is the informative term, consistent with the other ADAM rows. Proposed replacements: protease binding Supporting Evidence: PMID:17704059 the recombinant disintegrin-cysteine-rich domain of ADAM-9 specifically interacts with the beta1 integrin subunit on keratinocytes |
| GO:0005515 protein binding | IPI PMID:17925226 Rab25 associates with alpha5beta1 integrin to promote invasi... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:17925226; with/from UniProtKB:P57735. Reason: Generic protein binding is uninformative; the partner RAB25 (P57735) binds the beta1 cytoplasmic tail directly and directs alpha5beta1 recycling to pseudopodial tips. Small GTPase binding is the informative term. Proposed replacements: small GTPase binding Supporting Evidence: PMID:17925226 we report a direct interaction between the beta1 integrin cytoplasmic tail and Rab25 |
| GO:0005515 protein binding | IPI PMID:18177638 Filamin A regulates cell spreading and survival via beta1 in... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:18177638; with/from UniProtKB:P21333. Reason: Generic protein binding is uninformative; the partner is filamin A (P21333); filamin A cooperates with beta1 integrins in spreading on collagen. Filamin binding is the informative term (direct binding: PMID:9722563). Proposed replacements: filamin binding Supporting Evidence: PMID:18177638 We conclude that filamin A integrates with beta1 integrins to mediate cell spreading and prevent apoptosis. PMID:9722563 the cytoplasmic domain of beta1-integrin specifically interacts with the cytoskeletal protein filamin |
| GO:0005515 protein binding | IPI PMID:19168626 An unrecognized extracellular function for an intracellular ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:19168626; with/from UniProtKB:P46109. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner CRKL (P46109), found to bind the beta1 PSI domain extracellularly in tumour-bearing mice; unusual, single-study, and no specific beta1 MF term follows. Supporting Evidence: PMID:19168626 we uncovered a direct, specific, and functional interaction between CRKL, an adapter protein [with Src homology 2 (SH2)- and SH3-containing domains], and the plexin-semaphorin-integrin domain of beta(1) integrin in the extracellular milieu |
| GO:0005515 protein binding | IPI PMID:19268462 Galectin-8 interacts with podoplanin and modulates lymphatic... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:19268462; with/from UniProtKB:O00214. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner galectin-8 (O00214), a lectin that binds glycans on alpha3beta1/alpha6beta1; no specific beta1 MF term follows. |
| GO:0005515 protein binding | IPI PMID:20159608 Matrix metalloproteinase-9 promotes chronic lymphocytic leuk... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:20159608; with/from UniProtKB:P07948. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner LYN (P07948); proMMP-9 binding to alpha4beta1 leads to Lyn activation. A kinase-binding term would overstate the evidence in the abstract. Supporting Evidence: PMID:20159608 This pathway is induced in all B-CLL cases, is active in B-CLL lymphoid tissues, and consists of Lyn activation, STAT3 phosphorylation, and Mcl-1 upregulation. |
| GO:0005515 protein binding | IPI PMID:20159608 Matrix metalloproteinase-9 promotes chronic lymphocytic leuk... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:20159608; with/from UniProtKB:P13612. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA4 (P13612); alpha4-beta1 pairing is captured by the complex rows. |
| GO:0005515 protein binding | IPI PMID:20183869 Characterization of L-plastin interaction with beta integrin... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:20183869; with/from UniProtKB:P13796. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner L-plastin (LCP1, P13796) binds the beta1 cytoplasmic domain; GO has no plastin-binding term and no more specific beta1 MF follows. Supporting Evidence: PMID:20183869 L-plastin binds to the cytoplasmic domain of beta1 integrin and to beta1 and beta2 peptides |
| GO:0005515 protein binding | IPI PMID:20802515 Inhibition of Ξ²1 integrin and IL-3RΞ² common subunit interact... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:20802515; with/from UniProtKB:P32927. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner IL-3 receptor common beta (CSF2RB, P32927); its juxtamembrane extracellular domain binds beta1. No specific beta1 MF term follows. |
| GO:0005515 protein binding | IPI PMID:21134644 Structural diversity in integrin/talin interactions. | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:21134644; with/from UniProtKB:P26039. Reason: Generic protein binding is uninformative; the partner is mouse talin-1 (P26039); NMR maps the beta1A and beta1D tail contacts with talin. Talin binding is the informative term. Proposed replacements: talin binding Supporting Evidence: PMID:21134644 revealing marked structural diversity in the contacts between Ξ²1A, Ξ²1D, and Ξ²3 tails and the Talin1 and Talin2 isoforms |
| GO:0005515 protein binding | IPI PMID:21397862 Angiopoietin-like 4 protein elevates the prosurvival intrace... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:21397862; with/from UniProtKB:Q9BY76. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ANGPTL4 (Q9BY76), an integrin ligand in anoikis resistance; the abstract does not specify beta1. No specific beta1 MF follows. |
| GO:0005515 protein binding | IPI PMID:21806020 The metastasis-promoting phosphatase PRL-3 shows activity to... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:21806020; with/from UniProtKB:P18031. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner PTP1B (PTPN1, P18031); the cached abstract (PRL-3 phosphatase on phosphoinositides) does not describe an ITGB1 interaction, and no specific beta1 MF follows. |
| GO:0005515 protein binding | IPI PMID:21947080 SHARPIN is an endogenous inhibitor of Ξ²1-integrin activation... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:21947080; with/from UniProtKB:P08648. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA5 (P08648) in a SHARPIN study; alpha5-beta1 pairing is captured by the complex rows. |
| GO:0005515 protein binding | IPI PMID:21947080 SHARPIN is an endogenous inhibitor of Ξ²1-integrin activation... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:21947080; with/from UniProtKB:P17301. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA2 (P17301) in a SHARPIN study; alpha2-beta1 pairing is captured by the complex rows. |
| GO:0005515 protein binding | IPI PMID:21947080 SHARPIN is an endogenous inhibitor of Ξ²1-integrin activation... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:21947080; with/from UniProtKB:P26039. Reason: Generic protein binding is uninformative; the partner is mouse talin-1 (P26039); the paper measures talin recruitment to beta1 integrins, which SHARPIN inhibits. Talin binding is the informative term. Proposed replacements: talin binding Supporting Evidence: PMID:21947080 We found that SHARPIN directly binds to a conserved cytoplasmic region of integrin Ξ±-subunits and inhibits recruitment of talin and kindlin to the integrin. |
| GO:0005515 protein binding | IPI PMID:22178926 Basic amino-acid side chains regulate transmembrane integrin... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:22178926; with/from UniProtKB:P08648. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA5 (P08648) in a transmembrane signalling study; pairing is captured by the complex rows. |
| GO:0005515 protein binding | IPI PMID:22413019 A disintegrin and metalloenzyme (ADAM) 17 activation is regu... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:22413019; with/from UniProtKB:P78536. Reason: Generic protein binding is uninformative; the partner ADAM17 (P78536) co-precipitates with alpha5beta1 and is regulated by it. Protease binding is the informative term, consistent with the other ADAM17 rows. Proposed replacements: protease binding Supporting Evidence: PMID:22413019 in unstimulated mesangial cell lysates Ξ±5Ξ²1 integrin co-precipitated with ADAM17 |
| GO:0005515 protein binding | IPI PMID:22451694 Crystal structure of Ξ±5Ξ²1 integrin ectodomain: atomic detail... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:22451694; with/from UniProtKB:P08648. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA5 (P08648); the alpha5beta1 ectodomain crystal structure. Pairing is captured by the integrin alpha5-beta1 complex rows. |
| GO:0005515 protein binding | IPI PMID:22523556 Angiotensin converting enzyme (ACE) and ACE2 bind integrins ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:22523556; with/from UniProtKB:P12821-3. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ACE (P12821-3); ACE and ACE2 bind integrins, but the binding is not via a defined beta1 activity and no specific MF term follows. Supporting Evidence: PMID:22523556 The reported observation that ACE2 binds integrin Ξ²1 (ITGB1) in the failing human heart [25] adds another dimension to the role of the ACE family in cardiac homeostasis. |
| GO:0005515 protein binding | IPI PMID:22523556 Angiotensin converting enzyme (ACE) and ACE2 bind integrins ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:22523556; with/from UniProtKB:Q9BYF1. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ACE2 (Q9BYF1); as for ACE, no specific beta1 MF term follows. Supporting Evidence: PMID:22523556 The reported observation that ACE2 binds integrin Ξ²1 (ITGB1) in the failing human heart [25] adds another dimension to the role of the ACE family in cardiac homeostasis. |
| GO:0005515 protein binding | IPI PMID:22940691 Endoglin mediates fibronectin/Ξ±5Ξ²1 integrin and TGF-Ξ² pathwa... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:22940691; with/from UniProtKB:P17813. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner endoglin (P17813); fibronectin/alpha5beta1 promote endoglin/ALK1 complex formation. No specific beta1 MF term follows. Supporting Evidence: PMID:22940691 Fibronectin and Ξ±5Ξ²1 integrin increase Smad1/5/8 signalling by promoting endoglin/ALK1 cell surface complex formation. |
| GO:0005515 protein binding | IPI PMID:24789099 The chemokine fractalkine can activate integrins without CX3... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:24789099; with/from UniProtKB:P78423. Reason: Generic protein binding is uninformative; the partner is fractalkine (CX3CL1, P78423), whose chemokine domain binds alpha4beta1 directly. C-X3-C chemokine binding is the informative term (also annotated by IDA from PMID:23125415). Proposed replacements: C-X3-C chemokine binding Supporting Evidence: PMID:24789099 We recently discovered that the chemokine domain of FKN (FKN-CD) binds to integrins Ξ±4Ξ²1 and Ξ±vΞ²3 |
| GO:0005515 protein binding | IPI PMID:25661773 A novel intracellular fibulin-1D variant binds to the cytopl... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:25661773; with/from UniProtKB:P23142. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner fibulin-1 (P23142); an intracellular fibulin-1D variant binds the beta1 tail. No specific beta1 MF term follows. |
| GO:0005515 protein binding | IPI PMID:25661773 A novel intracellular fibulin-1D variant binds to the cytopl... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:25661773; with/from UniProtKB:Q8NBH6. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner fibulin-1 isoform entry (Q8NBH6); as for the P23142 row. |
| GO:0005515 protein binding | IPI PMID:25694433 Direct interactions with the integrin Ξ²1 cytoplasmic tail ac... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:25694433; with/from UniProtKB:P42684. Reason: Generic protein binding is uninformative; the partner Abl2/Arg (P42684) kinase domain binds the beta1 tail directly and phosphorylates Tyr-783. Protein tyrosine kinase binding is the informative term. Proposed replacements: protein tyrosine kinase binding Supporting Evidence: PMID:25694433 We report here that the Arg kinase domain interacts directly with a lysine-rich membrane-proximal segment in the integrin Ξ²1 cytoplasmic tail |
| GO:0005515 protein binding | IPI PMID:2649503 Association of the VLA alpha 6 subunit with a novel protein.... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:2649503; with/from UniProtKB:P23229. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA6 (P23229); the paper shows alpha6 pairs with beta1 or beta4. Pairing is captured by the integrin alpha6-beta1 complex row. Supporting Evidence: PMID:2649503 VLA-6 is a typical integrin heterodimer, with alpha 6-beta 1 subunit association |
| GO:0005515 protein binding | IPI PMID:30021884 Histone Interaction Landscapes Visualized by Crosslinking Ma... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:30021884; with/from UniProtKB:P08648. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA5; crosslinking mass spectrometry of histone interaction landscapes, a high-throughput dataset. |
| GO:0005515 protein binding | IPI PMID:30455686 CD9 Controls Integrin Ξ±5Ξ²1-Mediated Cell Adhesion by Modulat... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:30455686; with/from UniProtKB:P78536. Reason: Generic protein binding is uninformative; the partner ADAM17 (P78536) is an alternative counter-receptor of alpha5beta1, regulated by CD9. Protease binding is the informative term, consistent with the other ADAM17 rows. Proposed replacements: protease binding Supporting Evidence: PMID:30455686 through binding to an alternative counter-receptor, the metalloproteinase ADAM17/TACE |
| GO:0005515 protein binding | IPI PMID:31331973 Integrin Binding to the Trimeric Interface of CD40L Plays a ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:31331973; with/from UniProtKB:P08648, UniProtKB:P29965. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partners ITGA5 and CD40LG (P29965); alpha5beta1 binding to CD40L is captured by the CD40 signaling pathway row and needs no generic binding term. Supporting Evidence: PMID:31331973 Several CD40L mutants defective in integrin binding were defective in NF-ΞΊB activation and B cell activation and suppressed CD40L signaling induced by wild-type CD40L |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:32814053; with/from UniProtKB:O60784-2. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner TOM1 (O60784-2) from a systematic yeast two-hybrid neurodegeneration interactome; no follow-up for beta1. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:32814053; with/from UniProtKB:P05067. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner APP (P05067) from a systematic yeast two-hybrid neurodegeneration interactome; no follow-up for beta1. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:32814053; with/from UniProtKB:P27986-2. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner PIK3R1 (P27986-2) from a systematic yeast two-hybrid neurodegeneration interactome; no follow-up for beta1. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:32814053; with/from UniProtKB:Q13387-4. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner MAPK8IP2 (Q13387-4) from a systematic yeast two-hybrid neurodegeneration interactome; no follow-up for beta1. |
| GO:0005515 protein binding | IPI PMID:33102950 The Integrin Binding Peptide, ATN-161, as a Novel Therapy fo... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:33102950; with/from UniProtKB:P08648, UniProtKB:P0DTC2, UniProtKB:Q9BYF1. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partners ITGA5, SARS-CoV-2 spike (P0DTC2) and ACE2 in a study of the integrin-binding peptide ATN-161; the evidence does not establish a specific beta1 activity such as virus receptor activity. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:33961781; with/from UniProtKB:P08648. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA5 from a proteome-scale interaction network (high-throughput). |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:33961781; with/from UniProtKB:P23229. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ITGA6 from a proteome-scale interaction network (high-throughput). |
| GO:0005515 protein binding | IPI PMID:33962943 Structural insights into integrin Ξ±(5)Ξ²(1) opening by fibron... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:33962943; with/from UniProtKB:P02751, UniProtKB:P08648. Reason: Generic protein binding is uninformative; the row records alpha5beta1 (with ITGA5) binding fibronectin (P02751) in the cryo-EM structure; FN contacts the beta1 ADMIDAS directly. Fibronectin binding is the informative term. Proposed replacements: fibronectin binding Supporting Evidence: PMID:33962943 key interactions centered at R1445 and Y1446 of FN and D137 of ADMIDAS in Ξ²1 Ξ²I domain provide an additional anchoring point that triggers the opening of Ξ±5Ξ²1 |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:35384245; with/from UniProtKB:P08069. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner IGF1R from a receptor tyrosine kinase interactome atlas (high-throughput). |
| GO:0005515 protein binding | IPI PMID:35802072 The integrin ligand SVEP1 regulates GPCR-mediated vasoconstr... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:35802072; with/from UniProtKB:Q4LDE5. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner SVEP1 (Q4LDE5), a ligand of alpha9beta1 and alpha4beta1 in vascular smooth muscle; the functional consequence is captured by the vasoconstriction row. Supporting Evidence: PMID:35802072 The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins Ξ±9Ξ²1 and Ξ±4Ξ²1. |
| GO:0005515 protein binding | IPI PMID:37184585 The C-type lectin domain of CD62P (P-selectin) functions as ... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:37184585; with/from UniProtKB:P16109. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner P-selectin (P16109), whose C-type lectin domain is reported as an integrin ligand; no specific beta1 MF term follows. |
| GO:0005515 protein binding | IPI PMID:9281591 ICAP-1, a novel beta1 integrin cytoplasmic domain-associated... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:9281591; with/from UniProtKB:O14713. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner ICAP-1 (ITGB1BP1, O14713), which binds the beta1 NPXY motif. GO has no ICAP-1-binding term; no specific beta1 MF follows. Supporting Evidence: PMID:9281591 ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. |
| GO:0005515 protein binding | IPI PMID:9360996 NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein t... | REMOVE | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:9360996; with/from UniProtKB:O14817. Reason: Generic protein binding is uninformative under the repository policy; removal does not mean the reported interaction is false. Partner tetraspanin NAG-2/TSPAN4 (O14817) in TM4SF-integrin complexes; no specific beta1 MF follows. |
| GO:0005515 protein binding | IPI PMID:9722563 Filamin binds to the cytoplasmic domain of the beta1-integri... | MODIFY | Summary: IPI annotation of ITGB1 to protein binding (GO:0005515) from PMID:9722563; with/from UniProtKB:P21333. Reason: Generic protein binding is uninformative; the paper maps filamin binding to the beta1 cytoplasmic domain by two-hybrid, co-precipitation and in vitro binding. Filamin binding is the informative term. Proposed replacements: filamin binding Supporting Evidence: PMID:9722563 the cytoplasmic domain of beta1-integrin specifically interacts with the cytoskeletal protein filamin |
| GO:0005737 cytoplasm | IDA PMID:16803572 Role of dystrophins and utrophins in platelet adhesion proce... | MARK AS OVER ANNOTATED | Summary: IDA annotation of ITGB1 to cytoplasm (GO:0005737) from PMID:16803572. Reason: Beta1 integrin is a type I transmembrane receptor of the plasma membrane and endosomes. A platelet co-IP/immunofluorescence study does not establish a cytoplasmic (soluble) pool; the annotation probably reflects the cytoplasmic tail or intracellular membranes and is imprecise. Supporting Evidence: PMID:16803572 their potential association with integrin beta-1 fraction and the focal adhesion system (alpha-actinin, vinculin and talin) was evaluated by immunofluorescence and immunoprecipitation assays |
| GO:0005886 plasma membrane | EXP PMID:17158881 alphaVbeta6 is a novel receptor for human fibrillin-1. Compa... | ACCEPT | Summary: EXP annotation of ITGB1 to plasma membrane (GO:0005886) from PMID:17158881. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | EXP PMID:32487760 GRP78 and Integrins Play Different Roles in Host Cell Invasi... | ACCEPT | Summary: EXP annotation of ITGB1 to plasma membrane (GO:0005886) from PMID:32487760. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | EXP PMID:35687021 PEAK1 Y635 phosphorylation regulates cell migration through ... | ACCEPT | Summary: EXP annotation of ITGB1 to plasma membrane (GO:0005886) from PMID:35687021. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | ACCEPT | Summary: IDA annotation of ITGB1 to plasma membrane (GO:0005886) from GO_REF:0000052. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | IDA PMID:12869515 JAML, a novel protein with characteristics of a junctional a... | ACCEPT | Summary: IDA annotation of ITGB1 to plasma membrane (GO:0005886) from PMID:12869515. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | IDA PMID:16803572 Role of dystrophins and utrophins in platelet adhesion proce... | ACCEPT | Summary: IDA annotation of ITGB1 to plasma membrane (GO:0005886) from PMID:16803572. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | IDA PMID:21310825 The androgen receptor induces integrin Ξ±6Ξ²1 to promote prost... | ACCEPT | Summary: IDA annotation of ITGB1 to plasma membrane (GO:0005886) from PMID:21310825. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: IEA annotation of ITGB1 to plasma membrane (GO:0005886) from GO_REF:0000120; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457, UniProtKB-SubCell:SL-0039. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | NAS PMID:10455171 A novel protease-docking function of integrin at invadopodia... | ACCEPT | Summary: NAS annotation of ITGB1 to plasma membrane (GO:0005886) from PMID:10455171. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-198941 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-198941. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-202706 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-202706. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-202723 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-202723. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-204434 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-204434. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-216043 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-216043. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-216045 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-216045. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-216048 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-216048. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-216050 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-216050. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-216058 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-216058. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-216064 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-216064. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-216068 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-216068. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2327695 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2327695. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2327746 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2327746. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2328037 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2328037. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2395320 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2395320. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2396029 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2396029. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2426259 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2426259. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2426471 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2426471. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2484965 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2484965. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-265424 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-265424. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-265428 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-265428. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-265429 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-265429. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2681667 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2681667. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2731074 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-2731074. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-349626 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-349626. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-374686 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-374686. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-3907292 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-3907292. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4084903 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4084903. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4084912 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4084912. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4085083 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4085083. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4085133 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4085133. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4086132 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4086132. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4086216 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4086216. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4086223 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4086223. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4088220 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4088220. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-4088264 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-4088264. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-432897 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-432897. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5666049 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-5666049. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6788346 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-6788346. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8875531 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-8875531. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9609689 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-9609689. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9610867 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-9610867. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9611147 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-9611147. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9611158 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-9611158. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9624017 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-9624017. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9679740 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-9679740. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9865215 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-9865215. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9865226 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-HSA-9865226. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-2473498 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-NUL-2473498. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-2545201 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-NUL-2545201. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-2752136 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-NUL-2752136. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-3907289 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-NUL-3907289. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-4084899 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-NUL-4084899. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-4084908 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-NUL-4084908. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-4084922 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-NUL-4084922. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-4085088 | ACCEPT | Summary: TAS annotation of ITGB1 to plasma membrane (GO:0005886) from Reactome:R-NUL-4085088. Reason: Beta1 integrin is a single-pass type I plasma membrane protein; plasma membrane localization is correct and core for an adhesion receptor. Supporting Evidence: PMID:33962943 Integrin Ξ±5Ξ²1 connects to the FN ligand, a major component of the ECM, through its extracellular domains and to the actin cytoskeleton through its cytoplasmic tail domains in combination with accessory factors |
| GO:0005925 focal adhesion | HDA PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome... | ACCEPT | Summary: HDA annotation of ITGB1 to focal adhesion (GO:0005925) from PMID:21423176. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0005925 focal adhesion | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to focal adhesion (GO:0005925) from GO_REF:0000033; with/from FB:FBgn0004657, MGI:MGI:96612, MGI:MGI:96614, PANTHER:PTN000801545. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0005925 focal adhesion | IDA GO_REF:0000052 | ACCEPT | Summary: IDA annotation of ITGB1 to focal adhesion (GO:0005925) from GO_REF:0000052. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0005925 focal adhesion | IDA PMID:12417594 The LIM protein Ajuba is recruited to cadherin-dependent cel... | ACCEPT | Summary: IDA annotation of ITGB1 to focal adhesion (GO:0005925) from PMID:12417594. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0005925 focal adhesion | IDA PMID:14970227 Integrin alpha5beta1 and ADAM-17 interact in vitro and co-lo... | ACCEPT | Summary: IDA annotation of ITGB1 to focal adhesion (GO:0005925) from PMID:14970227. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0005925 focal adhesion | IDA PMID:17158881 alphaVbeta6 is a novel receptor for human fibrillin-1. Compa... | ACCEPT | Summary: IDA annotation of ITGB1 to focal adhesion (GO:0005925) from PMID:17158881. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0005925 focal adhesion | IDA PMID:23023225 Integrins Ξ²1 and Ξ²3 exhibit distinct dynamic nanoscale organ... | ACCEPT | Summary: IDA annotation of ITGB1 to focal adhesion (GO:0005925) from PMID:23023225. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0005925 focal adhesion | IDA PMID:29162887 The WD40-domain containing protein CORO2B is specifically en... | ACCEPT | Summary: IDA annotation of ITGB1 to focal adhesion (GO:0005925) from PMID:29162887. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0005925 focal adhesion | IEA GO_REF:0000044 | ACCEPT | Summary: IEA annotation of ITGB1 to focal adhesion (GO:0005925) from GO_REF:0000044; with/from UniProtKB-SubCell:SL-0118. Reason: Beta1 integrins are core focal adhesion components, where they link fibronectin to talin and actin. Supported by imaging and focal adhesion proteomics. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. PMID:29162887 SILAC-MS analysis of purified focal adhesions revealed an impaired recruitment of the integrin receptor dimers ITGB1/ITGAV as well as ITGA5 to focal adhesions sites |
| GO:0006909 phagocytosis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to phagocytosis (GO:0006909) from GO_REF:0000024; with/from UniProtKB:P49134. Reason: ISS from rat beta1 (P49134). Beta1 integrins mediate binding and uptake of some particles and microbes; this is a specialised, animal-specific role, kept as non-core. |
| GO:0006968 cellular defense response | TAS PMID:10201960 Eotaxin activates T cells to chemotaxis and adhesion only if... | REMOVE | Summary: TAS annotation of ITGB1 to cellular defense response (GO:0006968) from PMID:10201960. Reason: The cited paper shows that eotaxin with IL-2/IL-4 increases CD29 (beta1) expression on T cells and promotes adhesion; this does not show beta1 carrying out a cellular defense response. The term is not supported for ITGB1. Supporting Evidence: PMID:10201960 eotaxin enhances the expression of adhesion molecules such as ICAM-1 and several integrins (CD29, CD49a, and CD49b) on T lymphocytes |
| GO:0007155 cell adhesion | IDA PMID:19703720 Adhesion of human haematopoietic (CD34+) stem cells to human... | ACCEPT | Summary: IDA annotation of ITGB1 to cell adhesion (GO:0007155) from PMID:19703720. Reason: CD34+ stem cells bind liver cells through beta1 integrin and VCAM-1; cell adhesion is correct (more specific terms are carried by other rows). Supporting Evidence: PMID:19703720 Binding to BEC was mediated by the interaction of beta1 and beta2 integrins with VCAM-1 and ICAM-1 respectively. |
| GO:0007156 homophilic cell-cell adhesion | TAS PMID:10201960 Eotaxin activates T cells to chemotaxis and adhesion only if... | REMOVE | Summary: TAS annotation of ITGB1 to homophilic cell-cell adhesion (GO:0007156) from PMID:10201960. Reason: Integrins mediate heterophilic adhesion (to ECM ligands or counter-receptors such as VCAM1), not homophilic adhesion between identical molecules. The cited paper only reports eotaxin up-regulating CD29 expression. Supporting Evidence: PMID:10201960 eotaxin enhances the expression of adhesion molecules such as ICAM-1 and several integrins (CD29, CD49a, and CD49b) on T lymphocytes |
| GO:0007159 leukocyte cell-cell adhesion | IDA PMID:1715889 Vascular cell adhesion molecule-1 and the integrin VLA-4 med... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to leukocyte cell-cell adhesion (GO:0007159) from PMID:1715889. Reason: Alpha4beta1 (VLA-4) on B cell precursors binds VCAM-1 on marrow stromal cells; a real leukocyte cell-cell adhesion function of beta1, but tissue-specific and animal-specific. Supporting Evidence: PMID:1715889 indicating that VLA-4/VCAM-1 interactions are important in adhesion of B cell precursors to the bone marrow microenvironment |
| GO:0007159 leukocyte cell-cell adhesion | NAS PMID:30819933 Regulation of cell migration by Ξ±4 and Ξ±9 integrins. | KEEP AS NON CORE | Summary: NAS annotation of ITGB1 to leukocyte cell-cell adhesion (GO:0007159) from PMID:30819933. Reason: Review of alpha4 and alpha9 integrins (both pair with beta1) in leukocyte migration; consistent with the IDA evidence from PMID:1715889. Supporting Evidence: PMID:1715889 indicating that VLA-4/VCAM-1 interactions are important in adhesion of B cell precursors to the bone marrow microenvironment |
| GO:0007160 cell-matrix adhesion | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from GO_REF:0000033; with/from MGI:MGI:96610, MGI:MGI:96612, MGI:MGI:96615, PANTHER:PTN000801545. Reason: PAINT IBA for cell-matrix adhesion on the integrin beta node; this is the core process of beta1 integrins and is ancestral to integrin betas (Capsaspora integrin beta2 mediates substrate adhesion). Supporting Evidence: PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. PMID:32857975 using a specific antibody for integrin Ξ²2, we inhibited cell adhesion to a fibronectin-coated surface |
| GO:0007160 cell-matrix adhesion | IEA GO_REF:0000117 | ACCEPT | Summary: IEA annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from GO_REF:0000117; with/from ARBA:ARBA00085356. Reason: ARBA prediction agreeing with the experimental evidence for cell-matrix adhesion by beta1 integrins. Supporting Evidence: PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0007160 cell-matrix adhesion | IMP PMID:18156211 Regulation of endothelial cell cytoskeletal reorganization b... | ACCEPT | Summary: IMP annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from PMID:18156211. Reason: sFRP-1-induced endothelial spreading on extracellular matrix is integrin-dependent; beta1 acts in cell-matrix adhesion. Supporting Evidence: PMID:18156211 sFRP-1 treatment increases endothelial cell spreading on extracellular matrix as revealed by actin stress fiber reorganization in an integrin-dependent manner |
| GO:0007160 cell-matrix adhesion | IMP PMID:18308860 CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhe... | ACCEPT | Summary: IMP annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from PMID:18308860. Reason: Alpha4beta1 mediates rolling and static adhesion on VCAM-1 under flow; the curator scored cell-matrix adhesion by IMP. The core process is well established for beta1. Supporting Evidence: PMID:18308860 alpha(4)beta(1) mediated rolling and static adhesion on VCAM-1 |
| GO:0007160 cell-matrix adhesion | IMP PMID:24823363 Citrullination of collagen II affects integrin-mediated cell... | ACCEPT | Summary: IMP annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from PMID:24823363. Reason: Collagen-receptor beta1 integrins (alpha10beta1, alpha11beta1) mediate adhesion of synovial fibroblasts and MSCs to collagen II. Supporting Evidence: PMID:24823363 by specifically decreasing the binding of integrins Ξ±10Ξ²1 and Ξ±11Ξ²1 to arginine-containing motifs, such as GFOGER |
| GO:0007160 cell-matrix adhesion | IMP PMID:9679049 Knockout of alpha6 beta1-integrin expression reverses the tr... | ACCEPT | Summary: IMP annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from PMID:9679049. Reason: Loss of alpha6beta1 reduced adhesion and migration of HepG2 cells on laminin; cell-matrix adhesion by a beta1 integrin. Supporting Evidence: PMID:9679049 Stable transfectants of HepG2 that expressed the mutant beta4 subunit showed a reduced ability to adhere and migrate on laminin matrices |
| GO:0007160 cell-matrix adhesion | NAS PMID:19693543 Integrins. | ACCEPT | Summary: NAS annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from PMID:19693543. Reason: Author statement from a review/structure paper that beta1 integrins are ECM adhesion receptors; core process. Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0007160 cell-matrix adhesion | NAS PMID:22451694 Crystal structure of Ξ±5Ξ²1 integrin ectodomain: atomic detail... | ACCEPT | Summary: NAS annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from PMID:22451694. Reason: Author statement from a review/structure paper that beta1 integrins are ECM adhesion receptors; core process. Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0007160 cell-matrix adhesion | NAS PMID:30819933 Regulation of cell migration by Ξ±4 and Ξ±9 integrins. | ACCEPT | Summary: NAS annotation of ITGB1 to cell-matrix adhesion (GO:0007160) from PMID:30819933. Reason: Author statement from a review/structure paper that beta1 integrins are ECM adhesion receptors; core process. Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0007161 calcium-independent cell-matrix adhesion | IGI PMID:19651211 Mouse AMACO, a kidney and skin basement membrane associated ... | MODIFY | Summary: IGI annotation of ITGB1 to calcium-independent cell-matrix adhesion (GO:0007161) from PMID:19651211; with/from UniProtKB:Q70UZ7. Reason: Beta1 integrin-mediated, RGD-dependent adhesion to AMACO is shown, but the abstract says nothing about calcium independence, and beta1 ligand binding uses Ca2+ sites (ADMIDAS, SyMBS) besides the Mg2+ MIDAS. The essence is integrin-mediated cell-matrix adhesion. Proposed replacements: cell adhesion mediated by integrin Supporting Evidence: PMID:19651211 mouse AMACO was shown to support beta1 integrin-mediated adhesion of a keratinocyte-like cell line, HaCaT, and a fibroblast cell line, Wi26, in an RGD-dependent manner PMID:33962943 The integrin Ξ²I domain contains three functional metal ion pockets exhibiting clear densities, namely, MIDAS, ADMIDAS |
| GO:0007179 transforming growth factor beta receptor signaling pathway | IMP NOT PMID:24036928 Integrin-Ξ²5 and zyxin mediate formation of ventral stress fi... | ACCEPT | Summary: IMP annotation of ITGB1 to NOT transforming growth factor beta receptor signaling pathway (GO:0007179) from PMID:24036928. Reason: NOT annotation: beta1 knockdown did not affect TGF-beta-induced ventral stress fibres or paxillin phosphorylation, whereas beta5 was required. The negative result is clearly reported; the NOT annotation is accepted. Supporting Evidence: PMID:24036928 Knockdown of integrin-Ξ²1 by siRNA did not reduce TGF-Ξ²1-induced VSFs and phosphorylation of paxilin at Tyr31 |
| GO:0007229 integrin-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to integrin-mediated signaling pathway (GO:0007229) from GO_REF:0000033; with/from FB:FBgn0004657, MGI:MGI:96611, MGI:MGI:96612, MGI:MGI:96614. Reason: PAINT IBA for integrin-mediated signaling pathway on the integrin beta node; beta1 integrins initiate outside-in signalling (FAK, ILK, Src) at adhesions. Supporting Evidence: PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. |
| GO:0007229 integrin-mediated signaling pathway | IDA PMID:31331973 Integrin Binding to the Trimeric Interface of CD40L Plays a ... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin-mediated signaling pathway (GO:0007229) from PMID:31331973. Reason: Alpha5beta1 binding to CD40L is required for CD40L signalling; ITGB1 acts as the integrin receptor in this pathway. Supporting Evidence: PMID:31331973 Several CD40L mutants defective in integrin binding were defective in NF-ΞΊB activation and B cell activation and suppressed CD40L signaling induced by wild-type CD40L |
| GO:0007229 integrin-mediated signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: IEA annotation of ITGB1 to integrin-mediated signaling pathway (GO:0007229) from GO_REF:0000117; with/from ARBA:ARBA00084939. Reason: ARBA prediction agreeing with experimental evidence for beta1 integrin signalling. Supporting Evidence: PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. |
| GO:0007229 integrin-mediated signaling pathway | IMP PMID:24823363 Citrullination of collagen II affects integrin-mediated cell... | ACCEPT | Summary: IMP annotation of ITGB1 to integrin-mediated signaling pathway (GO:0007229) from PMID:24823363. Reason: Collagen-receptor beta1 integrins were tested for adhesion and signalling on citrullinated collagen; integrin-mediated signalling is a core beta1 process. Supporting Evidence: PMID:24823363 by specifically decreasing the binding of integrins Ξ±10Ξ²1 and Ξ±11Ξ²1 to arginine-containing motifs, such as GFOGER |
| GO:0007229 integrin-mediated signaling pathway | NAS PMID:19693543 Integrins. | ACCEPT | Summary: NAS annotation of ITGB1 to integrin-mediated signaling pathway (GO:0007229) from PMID:19693543. Reason: Author statement in reviews/structural papers that beta1 integrins signal after ligand binding; core process. Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. |
| GO:0007229 integrin-mediated signaling pathway | NAS PMID:22451694 Crystal structure of Ξ±5Ξ²1 integrin ectodomain: atomic detail... | ACCEPT | Summary: NAS annotation of ITGB1 to integrin-mediated signaling pathway (GO:0007229) from PMID:22451694. Reason: Author statement in reviews/structural papers that beta1 integrins signal after ligand binding; core process. Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. |
| GO:0007229 integrin-mediated signaling pathway | NAS PMID:30819933 Regulation of cell migration by Ξ±4 and Ξ±9 integrins. | ACCEPT | Summary: NAS annotation of ITGB1 to integrin-mediated signaling pathway (GO:0007229) from PMID:30819933. Reason: Author statement in reviews/structural papers that beta1 integrins signal after ligand binding; core process. Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. |
| GO:0007229 integrin-mediated signaling pathway | NAS PMID:9679049 Knockout of alpha6 beta1-integrin expression reverses the tr... | ACCEPT | Summary: NAS annotation of ITGB1 to integrin-mediated signaling pathway (GO:0007229) from PMID:9679049. Reason: Alpha6beta1 loss reduces adhesion, migration and anchorage-independent growth of hepatocarcinoma cells; integrin-mediated signalling by a beta1 integrin. Supporting Evidence: PMID:9679049 Stable transfectants of HepG2 that expressed the mutant beta4 subunit showed a reduced ability to adhere and migrate on laminin matrices |
| GO:0007520 myoblast fusion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to myoblast fusion (GO:0007520) from GO_REF:0000024; with/from UniProtKB:P07228. Reason: ISS from chicken beta1 (P07228); UniProt notes beta1 plays a role in myoblast differentiation and fusion (by similarity). Animal-specific tissue role, non-core. |
| GO:0008305 integrin complex | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to integrin complex (GO:0008305) from GO_REF:0000033; with/from FB:FBgn0004657, FB:FBgn0010395, MGI:MGI:1338035, MGI:MGI:96610. Reason: PAINT IBA for integrin complex; beta1 forms heterodimers with 12 alpha subunits. Core location. Supporting Evidence: PMID:2649503 VLA-6 is a typical integrin heterodimer, with alpha 6-beta 1 subunit association |
| GO:0008305 integrin complex | IC PMID:10655584 Activation of EphA2 kinase suppresses integrin function and ... | ACCEPT | Summary: IC annotation of ITGB1 to integrin complex (GO:0008305) from PMID:10655584; with/from GO:0004895. Reason: IC from cell adhesion receptor activity: an integrin beta subunit acts only as part of an alpha/beta heterodimer. Supporting Evidence: PMID:10655584 activation of endogenous EphA2 kinase induces an inactive conformation of integrins and inhibits cell spreading, migration and integrin-mediated adhesion |
| GO:0009897 external side of plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation of ITGB1 to external side of plasma membrane (GO:0009897) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl Compara transfer from mouse; the beta1 ectodomain faces the extracellular side of the plasma membrane. Correct. |
| GO:0009986 cell surface | HDA PMID:19581412 Quantitative proteomics identifies a Dab2/integrin module re... | ACCEPT | Summary: HDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:19581412. Reason: High-throughput cell-surface proteomics detects beta1 integrin at the cell surface; correct for a plasma membrane receptor. |
| GO:0009986 cell surface | HDA PMID:23382103 Platelet proteome analysis reveals integrin-dependent aggreg... | ACCEPT | Summary: HDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:23382103. Reason: High-throughput cell-surface proteomics detects beta1 integrin at the cell surface; correct for a plasma membrane receptor. |
| GO:0009986 cell surface | HDA PMID:23658023 Comparative proteomic analysis of supportive and unsupportiv... | ACCEPT | Summary: HDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:23658023. Reason: High-throughput cell-surface proteomics detects beta1 integrin at the cell surface; correct for a plasma membrane receptor. |
| GO:0009986 cell surface | HDA PMID:23981064 Mycobacterium tuberculosis infection of human dendritic cell... | ACCEPT | Summary: HDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:23981064. Reason: High-throughput cell-surface proteomics detects beta1 integrin at the cell surface; correct for a plasma membrane receptor. |
| GO:0009986 cell surface | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to cell surface (GO:0009986) from GO_REF:0000033; with/from MGI:MGI:96610, MGI:MGI:96611, MGI:MGI:96612, MGI:MGI:96613. Reason: PAINT IBA for cell surface on the integrin beta node; correct. |
| GO:0009986 cell surface | IDA PMID:17158881 alphaVbeta6 is a novel receptor for human fibrillin-1. Compa... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:17158881. Reason: Fibrillin-1 adhesion assays detect alpha5beta1 on the cell surface; correct. Supporting Evidence: PMID:17158881 our data suggest alpha5beta1 is a low affinity fibrillin-1 receptor |
| GO:0009986 cell surface | IDA PMID:1715889 Vascular cell adhesion molecule-1 and the integrin VLA-4 med... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:1715889. Reason: Flow cytometry of VLA-4/VLA-5 on B cell precursors; cell surface is correct. Supporting Evidence: PMID:1715889 indicating that VLA-4/VCAM-1 interactions are important in adhesion of B cell precursors to the bone marrow microenvironment |
| GO:0009986 cell surface | IDA PMID:19234460 A point mutation in KINDLIN3 ablates activation of three int... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:19234460. Reason: Kindlin-3 mutation study measures beta1 integrin on the leukocyte surface; cell surface is correct. |
| GO:0009986 cell surface | IDA PMID:19933311 Characterization of integrin engagement during defined human... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:19933311. Reason: Antibody blocking and flow cytometry of beta1 on hES cells; cell surface is correct. Supporting Evidence: PMID:19933311 only alpha(v)beta(3), alpha(6), beta(1), and alpha(2)beta(1) played a significant role in the initial adhesion of the hES cells to Matrigel in defined medium conditions |
| GO:0009986 cell surface | IDA PMID:20563599 Integrin expression and integrin-mediated adhesion in vitro ... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:20563599. Reason: Flow cytometry of beta1 on MSCs; cell surface is correct. Supporting Evidence: PMID:20563599 anti-beta1 to both HUVEC and HPAEC |
| GO:0009986 cell surface | IDA PMID:21310825 The androgen receptor induces integrin Ξ±6Ξ²1 to promote prost... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:21310825. Reason: Androgen receptor induces cell-surface alpha6beta1 in prostate tumour cells; cell surface is correct. Supporting Evidence: PMID:21310825 The androgen receptor induces integrin Ξ±6Ξ²1 to promote prostate tumor cell |
| GO:0009986 cell surface | IDA PMID:23023225 Integrins Ξ²1 and Ξ²3 exhibit distinct dynamic nanoscale organ... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:23023225. Reason: Single-protein tracking of surface beta1 integrins in focal adhesions; cell surface is correct. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. |
| GO:0009986 cell surface | IDA PMID:23154389 Regulation of endodermal differentiation of human embryonic ... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:23154389. Reason: Integrin expression on hESC-derived cells; cell surface is correct. Supporting Evidence: PMID:23154389 These data provide evidence that FN and VTN promote endoderm differentiation of hESCs through interaction with ITGA5 and ITGAV |
| GO:0009986 cell surface | IDA PMID:23620790 CBAP functions as a novel component in chemokine-induced ZAP... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:23620790. Reason: Beta1 detected at the T-cell surface in a chemokine signalling study; cell surface is correct. |
| GO:0009986 cell surface | IDA PMID:24036928 Integrin-Ξ²5 and zyxin mediate formation of ventral stress fi... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:24036928. Reason: Surface presentation of beta1 is measured in the integrin-beta5 study; cell surface is correct. Supporting Evidence: PMID:24036928 Depletion of either Ξ² subunit does not affect the level and surface presentation of the other. |
| GO:0009986 cell surface | IDA PMID:25063885 KSHV attachment and entry are dependent on Ξ±VΞ²3 integrin loc... | ACCEPT | Summary: IDA annotation of ITGB1 to cell surface (GO:0009986) from PMID:25063885. Reason: Alpha3beta1 is detected on actin-based cell-surface microdomains that bind KSHV; cell surface is correct. Supporting Evidence: PMID:25063885 Integrins Ξ±VΞ²3, Ξ±VΞ²5 and Ξ±3Ξ²1 were detected on essentially all the actin-based cell surface microdomains that initially bind KSHV |
| GO:0009986 cell surface | IEA GO_REF:0000120 | ACCEPT | Summary: IEA annotation of ITGB1 to cell surface (GO:0009986) from GO_REF:0000120; with/from ARBA:ARBA00027349, UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Combined automated annotation; cell surface is correct for beta1. |
| GO:0010008 endosome membrane | TAS Reactome:R-HSA-9611147 | KEEP AS NON CORE | Summary: TAS annotation of ITGB1 to endosome membrane (GO:0010008) from Reactome:R-HSA-9611147. Reason: Reactome places beta1 in endosome membranes during receptor trafficking. Beta1 integrins are endocytosed and recycled (ACAP1, Rab25); real but non-core. Supporting Evidence: PMID:16256741 We now show that ACAP1 also participates in the regulated recycling of integrin beta1 to control cell migration. |
| GO:0010710 regulation of collagen catabolic process | IDA PMID:10455171 A novel protease-docking function of integrin at invadopodia... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to regulation of collagen catabolic process (GO:0010710) from PMID:10455171. Reason: Alpha3beta1 docks the gelatinolytic protease seprase at invadopodia in a collagen-dependent way, which can promote matrix degradation; a regulatory, context-specific role. Supporting Evidence: PMID:10455171 The results show that alpha(3)beta(1) integrin is a docking protein for seprase to form functional invadopodia. |
| GO:0010763 positive regulation of fibroblast migration | IDA PMID:26763945 Focal Adhesion Kinase Regulates Fibroblast Migration via Int... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to positive regulation of fibroblast migration (GO:0010763) from PMID:26763945. Reason: Fibroblast migration on fibronectin depends on beta1 recruitment of FAK; a downstream consequence of adhesion receptor function. Supporting Evidence: PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. |
| GO:0014704 intercalated disc | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to intercalated disc (GO:0014704) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse; the muscle isoform beta1D is present at intercalated discs. Correct but tissue-specific. Supporting Evidence: PMID:9415431 beta1D is present at intercalated discs in cardiac muscle and at neuromuscular junctions in skeletal muscle cells |
| GO:0014850 response to muscle activity | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA annotation of ITGB1 to response to muscle activity (GO:0014850) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer of a mouse response term, probably based on expression changes after muscle activity. Expression change does not show beta1 performs a step of the response. |
| GO:0015026 coreceptor activity | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to coreceptor activity (GO:0015026) from GO_REF:0000117; with/from ARBA:ARBA00026504. Reason: ARBA prediction; alpha4beta1 is a fractalkine coreceptor and beta1 is modelled as coreceptor in the CD93 angiogenesis GO-CAM. Non-core. Supporting Evidence: PMID:23125415 Integrins Ξ±vΞ²3 and Ξ±4Ξ²1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. |
| GO:0015026 coreceptor activity | TAS PMID:23125415 Integrins Ξ±vΞ²3 and Ξ±4Ξ²1 act as coreceptors for fractalkine, ... | KEEP AS NON CORE | Summary: TAS annotation of ITGB1 to coreceptor activity (GO:0015026) from PMID:23125415. Reason: Alpha4beta1 acts with CX3CR1 as a coreceptor for fractalkine (ternary complex required for signalling). A specialised, animal-specific role. Supporting Evidence: PMID:23125415 Integrins Ξ±vΞ²3 and Ξ±4Ξ²1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. |
| GO:0016020 membrane | HDA PMID:19946888 Defining the membrane proteome of NK cells. | ACCEPT | Summary: HDA annotation of ITGB1 to membrane (GO:0016020) from PMID:19946888. Reason: NK cell membrane proteome detects beta1; membrane is correct though general. |
| GO:0016020 membrane | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation of ITGB1 to membrane (GO:0016020) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer; membrane is correct though general. |
| GO:0016477 cell migration | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to cell migration (GO:0016477) from GO_REF:0000033; with/from FB:FBgn0004657, MGI:MGI:96610, MGI:MGI:96611, MGI:MGI:96613. Reason: PAINT IBA for cell migration on the integrin beta node; beta1 integrins provide the traction adhesions of migrating cells. Supporting Evidence: PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. |
| GO:0016477 cell migration | TAS PMID:11919189 Integrin cytoplasmic domain-associated protein 1alpha (ICAP-... | ACCEPT | Summary: TAS annotation of ITGB1 to cell migration (GO:0016477) from PMID:11919189. Reason: The cited paper links beta1 engagement to lamellipodial adhesion sites of spreading/migrating cells; cell migration is a direct beta1 process. Supporting Evidence: PMID:11919189 These adhesion sites are enriched in occupied beta(1) integrins and precede the formation of focal adhesions devoid of ICAP-1alpha and nm23-H2 |
| GO:0019901 protein kinase binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation of ITGB1 to protein kinase binding (GO:0019901) from GO_REF:0000033; with/from PANTHER:PTN002560762, RGD:2927, UniProtKB:P05556, UniProtKB:P07228. Reason: PAINT IBA for protein kinase binding on the beta1 node (human beta1 among the seeds). Beta1 tails bind FAK and Abl2/Arg; valid but non-core. Supporting Evidence: PMID:25694433 We report here that the Arg kinase domain interacts directly with a lysine-rich membrane-proximal segment in the integrin Ξ²1 cytoplasmic tail |
| GO:0019960 C-X3-C chemokine binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation of ITGB1 to C-X3-C chemokine binding (GO:0019960) from GO_REF:0000033; with/from PANTHER:PTN002560762, UniProtKB:P05556. Reason: PAINT IBA (contributes_to) for C-X3-C chemokine binding seeded by human beta1; alpha4beta1 binds the fractalkine chemokine domain. Valid, non-core. Supporting Evidence: PMID:24789099 We recently discovered that the chemokine domain of FKN (FKN-CD) binds to integrins Ξ±4Ξ²1 and Ξ±vΞ²3 |
| GO:0019960 C-X3-C chemokine binding | IDA PMID:23125415 Integrins Ξ±vΞ²3 and Ξ±4Ξ²1 act as coreceptors for fractalkine, ... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to C-X3-C chemokine binding (GO:0019960) from PMID:23125415. Reason: Alpha4beta1 binds the fractalkine chemokine domain directly (contributes_to, as the heterodimer binds). Specialised, non-core. Supporting Evidence: PMID:23125415 Integrins Ξ±vΞ²3 and Ξ±4Ξ²1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. |
| GO:0023035 CD40 signaling pathway | IDA PMID:31331973 Integrin Binding to the Trimeric Interface of CD40L Plays a ... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to CD40 signaling pathway (GO:0023035) from PMID:31331973. Reason: Alpha5beta1 binding to CD40L is required for CD40/CD40L signalling. Real, immune-specific, non-core. Supporting Evidence: PMID:31331973 Several CD40L mutants defective in integrin binding were defective in NF-ΞΊB activation and B cell activation and suppressed CD40L signaling induced by wild-type CD40L |
| GO:0030027 lamellipodium | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to lamellipodium (GO:0030027) from GO_REF:0000044; with/from UniProtKB-SubCell:SL-0291. Reason: UniProt subcellular location mapping; beta1 is present in lamellipodia of migrating cells. Non-core. Supporting Evidence: PMID:11919189 These adhesion sites are enriched in occupied beta(1) integrins and precede the formation of focal adhesions devoid of ICAP-1alpha and nm23-H2 |
| GO:0030032 lamellipodium assembly | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to lamellipodium assembly (GO:0030032) from GO_REF:0000024; with/from UniProtKB:P49134. Reason: ISS from rat beta1 (P49134); beta1 adhesions support lamellipodium formation. Downstream, non-core. |
| GO:0030175 filopodium | IDA PMID:16803572 Role of dystrophins and utrophins in platelet adhesion proce... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to filopodium (GO:0030175) from PMID:16803572. Reason: Beta1 is found in platelet filopodia. Integrin-containing filopodial adhesions are also seen in Capsaspora (integrin beta2 with vinculin), so filopodial adhesion is plausibly ancestral, but for human beta1 this is a secondary site. Supporting Evidence: PMID:16803572 their potential association with integrin beta-1 fraction and the focal adhesion system (alpha-actinin, vinculin and talin) was evaluated by immunofluorescence and immunoprecipitation assays PMID:32857975 We show that integrin Ξ²2 and its associated protein vinculin localize as distinct patches in the filopodia. |
| GO:0030175 filopodium | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to filopodium (GO:0030175) from GO_REF:0000117; with/from ARBA:ARBA00085970. Reason: ARBA prediction for filopodium; consistent with the IDA row. Non-core. Supporting Evidence: PMID:32857975 We show that integrin Ξ²2 and its associated protein vinculin localize as distinct patches in the filopodia. |
| GO:0030183 B cell differentiation | IC PMID:1715889 Vascular cell adhesion molecule-1 and the integrin VLA-4 med... | MARK AS OVER ANNOTATED | Summary: IC annotation of ITGB1 to B cell differentiation (GO:0030183) from PMID:1715889; with/from GO:0007159. Reason: IC from leukocyte cell-cell adhesion. The paper shows alpha4beta1/VCAM-1 adhesion of B cell precursors to marrow stroma and only proposes that adhesion may be required for B cell development. Beta1 does not perform a step of B cell differentiation on this evidence. Supporting Evidence: PMID:1715889 Adhesion of B cell precursors to accessory cells in the bone marrow microenvironment may be required for normal early B cell development. |
| GO:0030198 extracellular matrix organization | NAS PMID:19693543 Integrins. | KEEP AS NON CORE | Summary: NAS annotation of ITGB1 to extracellular matrix organization (GO:0030198) from PMID:19693543. Reason: Beta1 integrins (alpha5beta1) drive fibronectin fibrillogenesis, a cell-mediated step in matrix assembly; real but downstream of the adhesion receptor activity. Supporting Evidence: PMID:29763414 CD93 colocalizes with activated Ξ²1 integrin chain in endothelial cells, and is required for full Ξ²1 integrin activation and fibronectin fibrillogenesis in vitro. |
| GO:0030316 osteoclast differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to osteoclast differentiation (GO:0030316) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse; alpha9beta1 regulates osteoclast formation. Tissue-specific, non-core. Supporting Evidence: PMID:16995821 Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. |
| GO:0030316 osteoclast differentiation | IGI PMID:16995821 Alpha9beta1: a novel osteoclast integrin that regulates oste... | KEEP AS NON CORE | Summary: IGI annotation of ITGB1 to osteoclast differentiation (GO:0030316) from PMID:16995821; with/from UniProtKB:Q13797. Reason: IGI with ITGA9: alpha9beta1 regulates osteoclast formation and function. Tissue-specific, non-core. Supporting Evidence: PMID:16995821 Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. |
| GO:0030335 positive regulation of cell migration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to positive regulation of cell migration (GO:0030335) from GO_REF:0000024; with/from UniProtKB:P49134. Reason: ISS from rat beta1; beta1 adhesion promotes migration. Non-core regulatory term. Supporting Evidence: PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. |
| GO:0031410 cytoplasmic vesicle | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to cytoplasmic vesicle (GO:0031410) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer (colocalizes_with); beta1 traffics in endocytic/recycling vesicles. Non-core. Supporting Evidence: PMID:17925226 we report a direct interaction between the beta1 integrin cytoplasmic tail and Rab25 |
| GO:0031589 cell-substrate adhesion | IMP PMID:19933311 Characterization of integrin engagement during defined human... | ACCEPT | Summary: IMP annotation of ITGB1 to cell-substrate adhesion (GO:0031589) from PMID:19933311. Reason: Antibody blocking shows beta1 integrins mediate initial adhesion of hES cells to Matrigel; cell-substrate adhesion is a core process. Supporting Evidence: PMID:19933311 only alpha(v)beta(3), alpha(6), beta(1), and alpha(2)beta(1) played a significant role in the initial adhesion of the hES cells to Matrigel in defined medium conditions |
| GO:0031589 cell-substrate adhesion | IMP PMID:19940135 Targeting of integrin beta1 and kinesin 2alpha by microRNA 1... | ACCEPT | Summary: IMP annotation of ITGB1 to cell-substrate adhesion (GO:0031589) from PMID:19940135. Reason: miR-183 targets ITGB1 and decreases adhesion to laminin, gelatin and collagen; cell-substrate adhesion by beta1. Supporting Evidence: PMID:19940135 it significantly decreased adhesion to laminin, gelatin, and collagen type I in normal human diploid fibroblasts and human trabecular meshwork cells |
| GO:0031594 neuromuscular junction | IDA PMID:9415431 Spatial and temporal expression of the beta1D integrin durin... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to neuromuscular junction (GO:0031594) from PMID:9415431. Reason: The beta1D isoform localizes to neuromuscular junctions in skeletal muscle. Tissue-specific, non-core. Supporting Evidence: PMID:9415431 beta1D is present at intercalated discs in cardiac muscle and at neuromuscular junctions in skeletal muscle cells |
| GO:0031594 neuromuscular junction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to neuromuscular junction (GO:0031594) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse; consistent with beta1D at neuromuscular junctions. Non-core. Supporting Evidence: PMID:9415431 beta1D is present at intercalated discs in cardiac muscle and at neuromuscular junctions in skeletal muscle cells |
| GO:0031623 receptor internalization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to receptor internalization (GO:0031623) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse for receptor internalization; beta1 integrins are internalized and recycled. Non-core. Supporting Evidence: PMID:16256741 We now show that ACAP1 also participates in the regulated recycling of integrin beta1 to control cell migration. |
| GO:0031623 receptor internalization | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to receptor internalization (GO:0031623) from GO_REF:0000024; with/from UniProtKB:P09055. Reason: ISS from mouse beta1 (P09055) for receptor internalization; integrin endocytosis is part of its trafficking cycle. Non-core. Supporting Evidence: PMID:16256741 We now show that ACAP1 also participates in the regulated recycling of integrin beta1 to control cell migration. |
| GO:0032154 cleavage furrow | EXP PMID:17956333 Interaction of integrin beta1 with cytokeratin 1 in neurobla... | KEEP AS NON CORE | Summary: EXP annotation of ITGB1 to cleavage furrow (GO:0032154) from PMID:17956333. Reason: EXP localization to the cleavage furrow (UniProt: beta1 plays an adhesive role in telophase needed for cytokinesis). The cached abstract (cytokeratin 1/Src/RACK1 complex) does not mention the furrow, so the curator's full-text basis is deferred to. Non-core. Supporting Evidence: PMID:17956333 the cytokeratin 1-Src-RACK1 complex was found to actively bind with membrane receptors such as integrin beta1 |
| GO:0032154 cleavage furrow | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to cleavage furrow (GO:0032154) from GO_REF:0000044; with/from UniProtKB-SubCell:SL-0467. Reason: UniProt subcellular location mapping to cleavage furrow; consistent with the EXP row. Non-core. |
| GO:0032587 ruffle membrane | IDA PMID:14970227 Integrin alpha5beta1 and ADAM-17 interact in vitro and co-lo... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to ruffle membrane (GO:0032587) from PMID:14970227. Reason: Alpha5beta1 colocalizes with ADAM17 in membrane ruffles of HeLa cells. Non-core site. Supporting Evidence: PMID:14970227 ADAM-17 and alpha(5)beta(1) were found to co-localize in both membrane ruffles and focal adhesions in HeLa cells |
| GO:0032587 ruffle membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to ruffle membrane (GO:0032587) from GO_REF:0000044; with/from UniProtKB-SubCell:SL-0301. Reason: UniProt subcellular location mapping to ruffle membrane. Non-core. |
| GO:0032587 ruffle membrane | NAS PMID:10455171 A novel protease-docking function of integrin at invadopodia... | KEEP AS NON CORE | Summary: NAS annotation of ITGB1 to ruffle membrane (GO:0032587) from PMID:10455171. Reason: Author statement on integrin localization at invadopodia/ruffle membranes; non-core. Supporting Evidence: PMID:10455171 The results show that alpha(3)beta(1) integrin is a docking protein for seprase to form functional invadopodia. |
| GO:0033627 cell adhesion mediated by integrin | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to cell adhesion mediated by integrin (GO:0033627) from GO_REF:0000033; with/from FB:FBgn0004657, MGI:MGI:96615, PANTHER:PTN000801545, RGD:2927. Reason: PAINT IBA for cell adhesion mediated by integrin; this is the defining process of integrin beta subunits and is ancestral (Capsaspora integrin beta2). Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. PMID:32857975 using a specific antibody for integrin Ξ²2, we inhibited cell adhesion to a fibronectin-coated surface |
| GO:0033627 cell adhesion mediated by integrin | IDA PMID:12807887 Cell adhesion to fibrillin-1 molecules and microfibrils is m... | ACCEPT | Summary: IDA annotation of ITGB1 to cell adhesion mediated by integrin (GO:0033627) from PMID:12807887. Reason: Alpha5beta1 mediates RGD- and cation-dependent fibroblast adhesion to fibrillin microfibrils. Supporting Evidence: PMID:12807887 alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors |
| GO:0033627 cell adhesion mediated by integrin | IDA PMID:17158881 alphaVbeta6 is a novel receptor for human fibrillin-1. Compa... | ACCEPT | Summary: IDA annotation of ITGB1 to cell adhesion mediated by integrin (GO:0033627) from PMID:17158881. Reason: Alpha5beta1-mediated cell adhesion to fibrillin-1 fragments; integrin-mediated adhesion. Supporting Evidence: PMID:17158881 our data suggest alpha5beta1 is a low affinity fibrillin-1 receptor |
| GO:0033627 cell adhesion mediated by integrin | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation of ITGB1 to cell adhesion mediated by integrin (GO:0033627) from GO_REF:0000024; with/from UniProtKB:P49134. Reason: ISS from rat beta1; consistent with the experimental rows. Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. |
| GO:0033631 cell-cell adhesion mediated by integrin | IEP PMID:17704059 Role of ADAM-9 disintegrin-cysteine-rich domains in human ke... | KEEP AS NON CORE | Summary: IEP annotation of ITGB1 to cell-cell adhesion mediated by integrin (GO:0033631) from PMID:17704059. Reason: IEP from an ADAM9 study: the ADAM9 disintegrin domain binds beta1 on keratinocytes. Beta1 does mediate cell-cell adhesion via counter-receptors (VCAM1, ADAMs), but this is secondary to matrix adhesion. Supporting Evidence: PMID:17704059 the recombinant disintegrin-cysteine-rich domain of ADAM-9 specifically interacts with the beta1 integrin subunit on keratinocytes |
| GO:0034113 heterotypic cell-cell adhesion | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to heterotypic cell-cell adhesion (GO:0034113) from GO_REF:0000117; with/from ARBA:ARBA00090976. Reason: ARBA prediction for heterotypic cell-cell adhesion; beta1 integrins mediate adhesion of leukocytes and stromal cells to endothelium. Non-core. |
| GO:0034113 heterotypic cell-cell adhesion | IMP PMID:20563599 Integrin expression and integrin-mediated adhesion in vitro ... | KEEP AS NON CORE | Summary: IMP annotation of ITGB1 to heterotypic cell-cell adhesion (GO:0034113) from PMID:20563599. Reason: Anti-beta1 antibodies reduce MSC adhesion to HUVEC and HPAEC; heterotypic cell-cell adhesion. Non-core. Supporting Evidence: PMID:20563599 anti-beta1 to both HUVEC and HPAEC |
| GO:0034665 integrin alpha1-beta1 complex | IDA PMID:24823363 Citrullination of collagen II affects integrin-mediated cell... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin alpha1-beta1 complex (GO:0034665) from PMID:24823363. Reason: Alpha1beta1 is a collagen receptor; recombinant alpha1 I domain and alpha1beta1-expressing cells used in collagen II binding. Supporting Evidence: PMID:24823363 by specifically decreasing the binding of integrins Ξ±10Ξ²1 and Ξ±11Ξ²1 to arginine-containing motifs, such as GFOGER |
| GO:0034665 integrin alpha1-beta1 complex | NAS PMID:22451694 Crystal structure of Ξ±5Ξ²1 integrin ectodomain: atomic detail... | ACCEPT | Summary: NAS annotation of ITGB1 to integrin alpha1-beta1 complex (GO:0034665) from PMID:22451694. Reason: Author statement on alpha1beta1 in the alpha5beta1 structure paper; alpha1beta1 is an established beta1 heterodimer. Supporting Evidence: PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0034666 integrin alpha2-beta1 complex | IDA PMID:24823363 Citrullination of collagen II affects integrin-mediated cell... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin alpha2-beta1 complex (GO:0034666) from PMID:24823363. Reason: Alpha2beta1 collagen receptor tested in the citrullinated collagen study. Supporting Evidence: PMID:24823363 by specifically decreasing the binding of integrins Ξ±10Ξ²1 and Ξ±11Ξ²1 to arginine-containing motifs, such as GFOGER |
| GO:0034666 integrin alpha2-beta1 complex | IPI PMID:14681217 Involvement of transmembrane domain interactions in signal t... | ACCEPT | Summary: IPI annotation of ITGB1 to integrin alpha2-beta1 complex (GO:0034666) from PMID:14681217. Reason: Alpha2 and beta1 transmembrane domains heterodimerize; alpha2beta1 is an established complex. Supporting Evidence: PMID:14681217 Our data suggest that the integrin transmembrane helices can help to stabilize heterodimeric integrins |
| GO:0034667 integrin alpha3-beta1 complex | IDA PMID:24220332 Disease-associated single amino acid mutation in the calf-1 ... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin alpha3-beta1 complex (GO:0034667) from PMID:24220332. Reason: Alpha3 (wild type and R628P) associates with beta1; alpha3beta1 is a laminin receptor. Supporting Evidence: PMID:24220332 The mutant Ξ±3 retained the ability to associate with integrin Ξ²1 |
| GO:0034667 integrin alpha3-beta1 complex | IDA PMID:25063885 KSHV attachment and entry are dependent on Ξ±VΞ²3 integrin loc... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin alpha3-beta1 complex (GO:0034667) from PMID:25063885. Reason: Alpha3beta1 detected on KSHV-binding cell surface microdomains. Supporting Evidence: PMID:25063885 Integrins Ξ±VΞ²3, Ξ±VΞ²5 and Ξ±3Ξ²1 were detected on essentially all the actin-based cell surface microdomains that initially bind KSHV |
| GO:0034668 integrin alpha4-beta1 complex | IPI PMID:1542691 A family of beta 7 integrins on human mucosal lymphocytes. | ACCEPT | Summary: IPI annotation of ITGB1 to integrin alpha4-beta1 complex (GO:0034668) from PMID:1542691. Reason: The paper notes alpha4 association with beta chains on mucosal lymphocytes; alpha4beta1 (VLA-4) is an established complex. |
| GO:0034668 integrin alpha4-beta1 complex | TAS PMID:8020569 Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2)... | ACCEPT | Summary: TAS annotation of ITGB1 to integrin alpha4-beta1 complex (GO:0034668) from PMID:8020569. Reason: VLA-4 (alpha4beta1) expression studied in myeloid cells; established complex. Supporting Evidence: PMID:8020569 Integrins are a family of cell surface heterodimers which mediate both cell-cell and cell-extracellular matrix interactions |
| GO:0034674 integrin alpha5-beta1 complex | IDA PMID:31331973 Integrin Binding to the Trimeric Interface of CD40L Plays a ... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin alpha5-beta1 complex (GO:0034674) from PMID:31331973. Reason: Alpha5beta1 binds CD40L; alpha5beta1 is the prototypic fibronectin receptor complex. Supporting Evidence: PMID:31331973 Several CD40L mutants defective in integrin binding were defective in NF-ΞΊB activation and B cell activation and suppressed CD40L signaling induced by wild-type CD40L |
| GO:0034674 integrin alpha5-beta1 complex | IDA PMID:33102950 The Integrin Binding Peptide, ATN-161, as a Novel Therapy fo... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin alpha5-beta1 complex (GO:0034674) from PMID:33102950. Reason: Alpha5beta1 is the target of ATN-161 in the SARS-CoV-2 study; established complex. |
| GO:0034674 integrin alpha5-beta1 complex | IPI PMID:22451694 Crystal structure of Ξ±5Ξ²1 integrin ectodomain: atomic detail... | ACCEPT | Summary: IPI annotation of ITGB1 to integrin alpha5-beta1 complex (GO:0034674) from PMID:22451694. Reason: Crystal structure of the alpha5beta1 ectodomain. Supporting Evidence: PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0034675 integrin alpha6-beta1 complex | IPI PMID:2649503 Association of the VLA alpha 6 subunit with a novel protein.... | ACCEPT | Summary: IPI annotation of ITGB1 to integrin alpha6-beta1 complex (GO:0034675) from PMID:2649503. Reason: VLA-6 is an alpha6-beta1 heterodimer on platelets and other cells. Supporting Evidence: PMID:2649503 VLA-6 is a typical integrin heterodimer, with alpha 6-beta 1 subunit association |
| GO:0034677 integrin alpha7-beta1 complex | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation of ITGB1 to integrin alpha7-beta1 complex (GO:0034677) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse; alpha7beta1 is the laminin receptor of muscle (beta1D pairs with alpha7). Correct. Supporting Evidence: PMID:9415431 In these myotubes, beta1D is associated with different alpha subunits, namely alpha3A, alpha5, alpha7A, or alpha7B. |
| GO:0034678 integrin alpha8-beta1 complex | TAS PMID:21335239 The basement membrane of hair follicle stem cells is a muscl... | ACCEPT | Summary: TAS annotation of ITGB1 to integrin alpha8-beta1 complex (GO:0034678) from PMID:21335239. Reason: Alpha8beta1 is the nephronectin receptor on mesenchymal cells of the hair follicle bulge. Supporting Evidence: PMID:21335239 thus regulating the adhesion of mesenchymal cells expressing the nephronectin receptor, Ξ±8Ξ²1 integrin, to the bulge |
| GO:0034679 integrin alpha9-beta1 complex | IEA GO_REF:0000120 | ACCEPT | Summary: IEA annotation of ITGB1 to integrin alpha9-beta1 complex (GO:0034679) from GO_REF:0000120; with/from ARBA:ARBA00092039, UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Combined automated annotation for alpha9beta1; correct. Supporting Evidence: PMID:16995821 Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. |
| GO:0034679 integrin alpha9-beta1 complex | IPI PMID:25748048 Association of p75(NTR) and Ξ±9Ξ²1 integrin modulates NGF-depe... | ACCEPT | Summary: IPI annotation of ITGB1 to integrin alpha9-beta1 complex (GO:0034679) from PMID:25748048. Reason: Alpha9beta1 associates with p75NTR; alpha9beta1 is an established complex. Supporting Evidence: PMID:25748048 Association of p75(NTR) and Ξ±9Ξ²1 integrin modulates NGF-dependent cellular responses |
| GO:0034679 integrin alpha9-beta1 complex | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation of ITGB1 to integrin alpha9-beta1 complex (GO:0034679) from GO_REF:0000024; with/from UniProtKB:P09055. Reason: ISS from mouse beta1 for alpha9beta1; correct. Supporting Evidence: PMID:16995821 Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. |
| GO:0034680 integrin alpha10-beta1 complex | IDA PMID:24823363 Citrullination of collagen II affects integrin-mediated cell... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin alpha10-beta1 complex (GO:0034680) from PMID:24823363. Reason: Alpha10beta1 collagen receptor tested on citrullinated collagen II. Supporting Evidence: PMID:24823363 by specifically decreasing the binding of integrins Ξ±10Ξ²1 and Ξ±11Ξ²1 to arginine-containing motifs, such as GFOGER |
| GO:0034680 integrin alpha10-beta1 complex | IPI PMID:9685391 Isolation, cloning, and sequence analysis of the integrin su... | ACCEPT | Summary: IPI annotation of ITGB1 to integrin alpha10-beta1 complex (GO:0034680) from PMID:9685391. Reason: Alpha10 was cloned as a beta1-associated collagen-binding integrin on chondrocytes. Supporting Evidence: PMID:9685391 chondrocytes express a novel collagen type II-binding integrin, a new member of the beta1-integrin family |
| GO:0034681 integrin alpha11-beta1 complex | IDA PMID:24823363 Citrullination of collagen II affects integrin-mediated cell... | ACCEPT | Summary: IDA annotation of ITGB1 to integrin alpha11-beta1 complex (GO:0034681) from PMID:24823363. Reason: Alpha11beta1 collagen receptor tested on citrullinated collagen II. Supporting Evidence: PMID:24823363 by specifically decreasing the binding of integrins Ξ±10Ξ²1 and Ξ±11Ξ²1 to arginine-containing motifs, such as GFOGER |
| GO:0034681 integrin alpha11-beta1 complex | NAS PMID:19693543 Integrins. | ACCEPT | Summary: NAS annotation of ITGB1 to integrin alpha11-beta1 complex (GO:0034681) from PMID:19693543. Reason: Author statement in an integrin review; alpha11beta1 is an established beta1 heterodimer. Supporting Evidence: PMID:19693543 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. |
| GO:0034682 integrin alphav-beta1 complex | IPI PMID:25398877 Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA... | ACCEPT | Summary: IPI annotation of ITGB1 to integrin alphav-beta1 complex (GO:0034682) from PMID:25398877. Reason: sPLA2-IIA binds site 2 in alpha4beta1 and alpha5beta1 and the curator recorded alphaVbeta1 binding; alphaVbeta1 is an established beta1 heterodimer (UniProt SUBUNIT). Supporting Evidence: PMID:25398877 Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins Ξ±vΞ²3, Ξ±4Ξ²1, and Ξ±5Ξ²1. |
| GO:0035313 wound healing, spreading of epidermal cells | NAS PMID:22451694 Crystal structure of Ξ±5Ξ²1 integrin ectodomain: atomic detail... | KEEP AS NON CORE | Summary: NAS annotation of ITGB1 to wound healing, spreading of epidermal cells (GO:0035313) from PMID:22451694. Reason: Author statement on alpha5beta1 in epidermal wound re-epithelialization; tissue-level, non-core. Supporting Evidence: PMID:22451694 Integrin Ξ±5Ξ²1 is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development. |
| GO:0035633 maintenance of blood-brain barrier | NAS PMID:30280653 Blood-Brain Barrier: From Physiology to Disease and Back. | UNDECIDED | Summary: NAS annotation of ITGB1 to maintenance of blood-brain barrier (GO:0035633) from PMID:30280653. Reason: NAS from a Physiological Reviews article on the blood-brain barrier; the cached abstract does not mention integrins, so the statement the curator used cannot be checked. Beta1 integrins of endothelium and astrocyte end-feet are plausible contributors, but this is unverified here. |
| GO:0035748 myelin sheath abaxonal region | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to myelin sheath abaxonal region (GO:0035748) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse (myelin sheath abaxonal region); beta1 integrins of Schwann cells bind laminin. Tissue-specific, non-core. |
| GO:0038023 signaling receptor activity | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation of ITGB1 to signaling receptor activity (GO:0038023) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer; integrins are bidirectional signalling receptors (ligand binding triggers outside-in signalling), and alpha4beta1/alpha6beta1 are functional receptors for midkine. Supporting Evidence: PMID:15466886 Therefore, we concluded that alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine. PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. |
| GO:0042383 sarcolemma | IDA PMID:9415431 Spatial and temporal expression of the beta1D integrin durin... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to sarcolemma (GO:0042383) from PMID:9415431. Reason: Beta1D concentrates at costameres of the sarcolemma in muscle. Tissue-specific. Supporting Evidence: PMID:9415431 In adults there is a distinct concentration of beta1D at the myotendinous junctions of muscle fibers and at costameres in both cardiac and skeletal muscle. |
| GO:0042383 sarcolemma | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to sarcolemma (GO:0042383) from GO_REF:0000120; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457, UniProtKB-SubCell:SL-0238. Reason: Combined automated annotation for sarcolemma; consistent with beta1D at costameres. Supporting Evidence: PMID:9415431 In adults there is a distinct concentration of beta1D at the myotendinous junctions of muscle fibers and at costameres in both cardiac and skeletal muscle. |
| GO:0042470 melanosome | EXP PMID:17081065 Proteomic and bioinformatic characterization of the biogenes... | MARK AS OVER ANNOTATED | Summary: EXP annotation of ITGB1 to melanosome (GO:0042470) from PMID:17081065. Reason: Detection in a melanosome proteome (about 1500 proteins across stages) does not show beta1 is a melanosome resident; plasma-membrane and endosomal proteins are expected in such preparations. Supporting Evidence: PMID:17081065 identified approximately 1500 proteins in melanosomes of all stages, with approximately 600 in any given stage |
| GO:0042470 melanosome | IEA GO_REF:0000120 | MARK AS OVER ANNOTATED | Summary: IEA annotation of ITGB1 to melanosome (GO:0042470) from GO_REF:0000120; with/from ARBA:ARBA00087229, UniProtKB-SubCell:SL-0161. Reason: Automated annotation based on the melanosome proteomics; over-annotation for the same reason as the EXP row. |
| GO:0043065 positive regulation of apoptotic process | IGI PMID:19364818 Fas-mediated apoptosis is regulated by the extracellular mat... | KEEP AS NON CORE | Summary: IGI annotation of ITGB1 to positive regulation of apoptotic process (GO:0043065) from PMID:19364818; with/from UniProtKB:P18406. Reason: IGI: CCN1 engages alpha6beta1 and syndecan-4 to enhance Fas-mediated apoptosis (ROS, p38). Beta1 is the receptor in a context-specific pro-apoptotic signal; non-core. Supporting Evidence: PMID:19364818 CCN1 acts through engagement of integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans |
| GO:0043065 positive regulation of apoptotic process | IGI PMID:19364818 Fas-mediated apoptosis is regulated by the extracellular mat... | KEEP AS NON CORE | Summary: IGI annotation of ITGB1 to positive regulation of apoptotic process (GO:0043065) from PMID:19364818; with/from UniProtKB:P23229. Reason: IGI: CCN1 engages alpha6beta1 and syndecan-4 to enhance Fas-mediated apoptosis (ROS, p38). Beta1 is the receptor in a context-specific pro-apoptotic signal; non-core. Supporting Evidence: PMID:19364818 CCN1 acts through engagement of integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans |
| GO:0043065 positive regulation of apoptotic process | IGI PMID:19364818 Fas-mediated apoptosis is regulated by the extracellular mat... | KEEP AS NON CORE | Summary: IGI annotation of ITGB1 to positive regulation of apoptotic process (GO:0043065) from PMID:19364818; with/from UniProtKB:P48023. Reason: IGI: CCN1 engages alpha6beta1 and syndecan-4 to enhance Fas-mediated apoptosis (ROS, p38). Beta1 is the receptor in a context-specific pro-apoptotic signal; non-core. Supporting Evidence: PMID:19364818 CCN1 acts through engagement of integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans |
| GO:0043149 stress fiber assembly | IMP NOT PMID:24036928 Integrin-Ξ²5 and zyxin mediate formation of ventral stress fi... | ACCEPT | Summary: IMP annotation of ITGB1 to NOT stress fiber assembly (GO:0043149) from PMID:24036928. Reason: NOT annotation: beta1 knockdown did not reduce TGF-beta-induced ventral stress fibres; integrin-beta5 was required. Clearly reported negative result. Supporting Evidence: PMID:24036928 Knockdown of integrin-Ξ²1 by siRNA did not reduce TGF-Ξ²1-induced VSFs and phosphorylation of paxilin at Tyr31 |
| GO:0043197 dendritic spine | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to dendritic spine (GO:0043197) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse (dendritic spine); neural, non-core. |
| GO:0043235 signaling receptor complex | IDA PMID:23382219 Structural basis for endosomal trafficking of diverse transm... | MARK AS OVER ANNOTATED | Summary: IDA annotation of ITGB1 to signaling receptor complex (GO:0043235) from PMID:23382219. Reason: The cited paper is a structural/screening study of SNX17/SNX27/SNX31 PX-FERM binding to NPxY cargos, which include integrins. It supports beta1 as an endosomal sorting cargo, not as part of a 'signaling receptor complex'. Supporting Evidence: PMID:23382219 In addition to previously identified cargos, including P-selectin ( 6 β 8 ), APP ( 9 , 10 ), integrins ( 11 , 12 ), and members of the LDLR family |
| GO:0043236 laminin binding | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to laminin binding (GO:0043236) from GO_REF:0000033; with/from MGI:MGI:96610, PANTHER:PTN002560762. Reason: PAINT IBA (contributes_to) for laminin binding on the beta1 node; alpha3beta1, alpha6beta1 and alpha7beta1 are laminin receptors and the heterodimer binds. Core ligand class. Supporting Evidence: PMID:9679049 Stable transfectants of HepG2 that expressed the mutant beta4 subunit showed a reduced ability to adhere and migrate on laminin matrices |
| GO:0043236 laminin binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation of ITGB1 to laminin binding (GO:0043236) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer (contributes_to) for laminin binding; correct. Supporting Evidence: PMID:9679049 Stable transfectants of HepG2 that expressed the mutant beta4 subunit showed a reduced ability to adhere and migrate on laminin matrices |
| GO:0043547 positive regulation of GTPase activity | IMP PMID:25911094 Odontogenic Ameloblast-associated Protein (ODAM) Mediates Ju... | KEEP AS NON CORE | Summary: IMP annotation of ITGB1 to positive regulation of GTPase activity (GO:0043547) from PMID:25911094. Reason: Fibronectin/laminin activate RhoA through an integrin-ODAM-ARHGEF5 pathway in junctional epithelium; the GTPase activation is carried out by ARHGEF5, downstream of the integrin. Indirect, non-core. Supporting Evidence: PMID:25911094 Fibronectin and laminin activated RhoA signaling via the integrin-ODAM pathway. |
| GO:0044877 protein-containing complex binding | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: IEA annotation of ITGB1 to protein-containing complex binding (GO:0044877) from GO_REF:0000117; with/from ARBA:ARBA00026521. Reason: ARBA prediction of protein-containing complex binding; too generic to be informative for beta1, whose specific binding activities are captured elsewhere. |
| GO:0044877 protein-containing complex binding | IPI PMID:25336636 An RGD motif present in cadherin 17 induces integrin activat... | MODIFY | Summary: IPI annotation of ITGB1 to protein-containing complex binding (GO:0044877) from PMID:25336636; with/from UniProtKB:P17301, UniProtKB:Q12864. Reason: The partner is cadherin-17 (Q12864), whose RGD motif binds alpha2beta1 and activates beta1. Cadherin binding is the informative term for this interaction. Proposed replacements: cadherin binding Supporting Evidence: PMID:25336636 Our results suggest that Ξ±2Ξ²1 integrin interacts with two different ligands, collagen IV and CDH17, using two different binding sites. |
| GO:0045121 membrane raft | IDA PMID:14559243 Association of the calpain/calpastatin network with subcellu... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to membrane raft (GO:0045121) from PMID:14559243. Reason: Beta1 integrin is used as a marker of membrane-raft fractions in density gradients; raft partitioning is a minor property. Supporting Evidence: PMID:14559243 as evidenced by their position in the gradient relative to calnexin, Rab6, caveolin, and beta1 integrin after laminin stimulation |
| GO:0045202 synapse | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation of ITGB1 to synapse (GO:0045202) from GO_REF:0000033; with/from MGI:MGI:96610, PANTHER:PTN002560762, RGD:2927, UniProtKB:P05556. Reason: PAINT IBA for synapse on the beta1 node; beta1 integrins act at synapses in neurons. Non-core. |
| GO:0045202 synapse | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to synapse (GO:0045202) from GO_REF:0000120; with/from ARBA:ARBA00027462, UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Combined automated annotation for synapse; non-core. |
| GO:0045296 cadherin binding | HDA PMID:25468996 E-cadherin interactome complexity and robustness resolved by... | MARK AS OVER ANNOTATED | Summary: HDA annotation of ITGB1 to cadherin binding (GO:0045296) from PMID:25468996. Reason: HDA from an E-cadherin proximity/interactome proteomics study; it does not show direct cadherin binding by beta1. Supporting Evidence: PMID:25468996 E-cadherin interactome complexity and robustness resolved by quantitative proteomics. |
| GO:0045445 myoblast differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to myoblast differentiation (GO:0045445) from GO_REF:0000024; with/from UniProtKB:P07228. Reason: ISS from chicken beta1; myoblast differentiation (UniProt, by similarity). Animal-specific tissue role. |
| GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway | IDA PMID:24044949 MicroRNA-223 antagonizes angiogenesis by targeting Ξ²1 integr... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to positive regulation of fibroblast growth factor receptor signaling pathway (GO:0045743) from PMID:24044949. Reason: Beta1 re-expression rescues FGF2 receptor phosphorylation in miR-223 overexpressing endothelial cells; beta1 supports growth-factor receptor signalling. Context-specific. Supporting Evidence: PMID:24044949 Reintroduction of Ξ²1 integrin into miR-223-ovexpressing cells was sufficient to rescue growth factor signaling and angiogenesis. |
| GO:0045766 positive regulation of angiogenesis | IMP PMID:24044949 MicroRNA-223 antagonizes angiogenesis by targeting Ξ²1 integr... | KEEP AS NON CORE | Summary: IMP annotation of ITGB1 to positive regulation of angiogenesis (GO:0045766) from PMID:24044949. Reason: Beta1 re-expression rescues angiogenesis in miR-223 overexpressing cells. Context-specific, animal-specific. Supporting Evidence: PMID:24044949 Reintroduction of Ξ²1 integrin into miR-223-ovexpressing cells was sufficient to rescue growth factor signaling and angiogenesis. |
| GO:0045780 positive regulation of bone resorption | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to positive regulation of bone resorption (GO:0045780) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse; alpha9beta1 promotes osteoclast function. Non-core. Supporting Evidence: PMID:16995821 Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. |
| GO:0045906 negative regulation of vasoconstriction | IMP PMID:35802072 The integrin ligand SVEP1 regulates GPCR-mediated vasoconstr... | KEEP AS NON CORE | Summary: IMP annotation of ITGB1 to negative regulation of vasoconstriction (GO:0045906) from PMID:35802072. Reason: SVEP1 acts through alpha9beta1 and alpha4beta1 to reduce vascular smooth muscle contraction. Tissue-specific, non-core. Supporting Evidence: PMID:35802072 The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins Ξ±9Ξ²1 and Ξ±4Ξ²1. |
| GO:0046982 protein heterodimerization activity | IDA PMID:10455171 A novel protease-docking function of integrin at invadopodia... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to protein heterodimerization activity (GO:0046982) from PMID:10455171. Reason: Beta1 heterodimerizes with alpha subunits (here alpha3beta1 in the seprase study). Correct but uninformative beyond complex membership; non-core. Supporting Evidence: PMID:10455171 The results show that alpha(3)beta(1) integrin is a docking protein for seprase to form functional invadopodia. |
| GO:0048333 mesodermal cell differentiation | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: IEA annotation of ITGB1 to mesodermal cell differentiation (GO:0048333) from GO_REF:0000117; with/from ARBA:ARBA00089498. Reason: ARBA prediction of mesodermal cell differentiation; no evidence that beta1 performs a step of mesoderm differentiation. |
| GO:0048333 mesodermal cell differentiation | IEP PMID:23154389 Regulation of endodermal differentiation of human embryonic ... | MARK AS OVER ANNOTATED | Summary: IEP annotation of ITGB1 to mesodermal cell differentiation (GO:0048333) from PMID:23154389. Reason: IEP from a study of integrin expression during hESC differentiation; the paper's functional conclusion concerns endoderm via ITGA5/ITGAV. An expression change does not show beta1 acts in mesodermal differentiation. Supporting Evidence: PMID:23154389 These data provide evidence that FN and VTN promote endoderm differentiation of hESCs through interaction with ITGA5 and ITGAV |
| GO:0048468 cell development | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: IEA annotation of ITGB1 to cell development (GO:0048468) from GO_REF:0000117; with/from ARBA:ARBA00028665. Reason: ARBA prediction of 'cell development' is too general to be informative for beta1. |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:20183869 Characterization of L-plastin interaction with beta integrin... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to perinuclear region of cytoplasm (GO:0048471) from PMID:20183869. Reason: L-plastin and beta1 integrin colocalize in a perinuclear region; intracellular pool, non-core. Supporting Evidence: PMID:20183869 L-plastin binds to the cytoplasmic domain of beta1 integrin and to beta1 and beta2 peptides |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to perinuclear region of cytoplasm (GO:0048471) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer (colocalizes_with) for perinuclear region; non-core. |
| GO:0050793 regulation of developmental process | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: IEA annotation of ITGB1 to regulation of developmental process (GO:0050793) from GO_REF:0000117; with/from ARBA:ARBA00028689. Reason: ARBA prediction of 'regulation of developmental process' is too general to be informative. |
| GO:0050804 modulation of chemical synaptic transmission | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to modulation of chemical synaptic transmission (GO:0050804) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse; beta1 integrins modulate synaptic transmission. Neural, non-core. |
| GO:0050839 cell adhesion molecule binding | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to cell adhesion molecule binding (GO:0050839) from GO_REF:0000117; with/from ARBA:ARBA00091792. Reason: ARBA prediction; alpha4beta1 and alpha9beta1 bind VCAM1, a cell adhesion molecule. Valid, non-core. Supporting Evidence: PMID:1715889 indicating that VLA-4/VCAM-1 interactions are important in adhesion of B cell precursors to the bone marrow microenvironment |
| GO:0050839 cell adhesion molecule binding | IPI PMID:12869515 JAML, a novel protein with characteristics of a junctional a... | KEEP AS NON CORE | Summary: IPI annotation of ITGB1 to cell adhesion molecule binding (GO:0050839) from PMID:12869515; with/from UniProtKB:Q86YT9. Reason: IPI with JAML (Q86YT9), an Ig-superfamily adhesion molecule on leukocytes (UniProt: alpha4beta1 controls JAML homodimerization). Valid, non-core. |
| GO:0050901 leukocyte tethering or rolling | IMP PMID:18308860 CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhe... | KEEP AS NON CORE | Summary: IMP annotation of ITGB1 to leukocyte tethering or rolling (GO:0050901) from PMID:18308860. Reason: Alpha4beta1 mediates lymphocyte rolling and static adhesion on VCAM-1 under shear flow. Leukocyte-specific. Supporting Evidence: PMID:18308860 alpha(4)beta(1) mediated rolling and static adhesion on VCAM-1 |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IDA PMID:24044949 MicroRNA-223 antagonizes angiogenesis by targeting Ξ²1 integr... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897) from PMID:24044949. Reason: Beta1 knockdown reproduces the loss of growth-factor-induced Akt signalling in endothelial cells. Context-specific regulation. Supporting Evidence: PMID:24044949 Reintroduction of Ξ²1 integrin into miR-223-ovexpressing cells was sufficient to rescue growth factor signaling and angiogenesis. |
| GO:0051951 positive regulation of glutamate uptake involved in transmission of nerve impulse | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to positive regulation of glutamate uptake involved in transmission of nerve impulse (GO:0051951) from GO_REF:0000024; with/from UniProtKB:P09055. Reason: ISS from mouse beta1 for regulation of glutamate uptake in synaptic transmission; neural, non-core. |
| GO:0055037 recycling endosome | EXP PMID:16256741 Phosphorylation of ACAP1 by Akt regulates the stimulation-de... | KEEP AS NON CORE | Summary: EXP annotation of ITGB1 to recycling endosome (GO:0055037) from PMID:16256741. Reason: ACAP1 controls stimulation-dependent recycling of beta1 from recycling endosomes; real trafficking compartment, non-core. Supporting Evidence: PMID:16256741 We now show that ACAP1 also participates in the regulated recycling of integrin beta1 to control cell migration. |
| GO:0055037 recycling endosome | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to recycling endosome (GO:0055037) from GO_REF:0000044; with/from UniProtKB-SubCell:SL-0232. Reason: UniProt location mapping for recycling endosome; consistent with the EXP row. Supporting Evidence: PMID:16256741 We now show that ACAP1 also participates in the regulated recycling of integrin beta1 to control cell migration. |
| GO:0070062 extracellular exosome | HDA PMID:19056867 Large-scale proteomics and phosphoproteomics of urinary exos... | KEEP AS NON CORE | Summary: HDA annotation of ITGB1 to extracellular exosome (GO:0070062) from PMID:19056867. Reason: Exosome proteomics (urine, prostatic secretion) detects beta1; membrane proteins are carried on exosomes. Non-core. |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | KEEP AS NON CORE | Summary: HDA annotation of ITGB1 to extracellular exosome (GO:0070062) from PMID:23533145. Reason: Exosome proteomics (urine, prostatic secretion) detects beta1; membrane proteins are carried on exosomes. Non-core. |
| GO:0070161 anchoring junction | IEA GO_REF:0000120 | ACCEPT | Summary: IEA annotation of ITGB1 to anchoring junction (GO:0070161) from GO_REF:0000120; with/from ARBA:ARBA00027154, UniProtKB-SubCell:SL-0038. Reason: Anchoring junction is the parent of focal adhesion and other cell-matrix junctions where beta1 resides; correct. Supporting Evidence: PMID:23023225 Immobilized Ξ²3-integrins are enriched and stationary within FAs, whereas immobilized Ξ²1-integrins are less enriched and exhibit rearward movements. |
| GO:0070161 anchoring junction | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation of ITGB1 to anchoring junction (GO:0070161) from GO_REF:0000024; with/from UniProtKB:P09055. Reason: ISS from mouse beta1; anchoring junction is correct. |
| GO:0071133 alpha9-beta1 integrin-ADAM8 complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to alpha9-beta1 integrin-ADAM8 complex (GO:0071133) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse; alpha9beta1 forms a complex with ADAM8. Specialised, non-core. |
| GO:0071404 cellular response to low-density lipoprotein particle stimulus | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA annotation of ITGB1 to cellular response to low-density lipoprotein particle stimulus (GO:0071404) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer of a mouse response-to-stimulus term (LDL particle). Beta1 is not known to perform a step of the cellular LDL response; over-annotation. |
| GO:0071404 cellular response to low-density lipoprotein particle stimulus | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS annotation of ITGB1 to cellular response to low-density lipoprotein particle stimulus (GO:0071404) from GO_REF:0000024; with/from UniProtKB:P09055. Reason: ISS from mouse beta1 (P09055) for cellular response to LDL particle stimulus; as for the IEA row. |
| GO:0071711 basement membrane organization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to basement membrane organization (GO:0071711) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse; beta1 integrins are needed for basement membrane assembly. Animal-specific, non-core. |
| GO:0072673 lamellipodium morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to lamellipodium morphogenesis (GO:0072673) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse for lamellipodium morphogenesis; non-core. |
| GO:0090303 positive regulation of wound healing | IDA PMID:26763945 Focal Adhesion Kinase Regulates Fibroblast Migration via Int... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to positive regulation of wound healing (GO:0090303) from PMID:26763945. Reason: FAK recruitment by beta1 drives fibroblast migration relevant to wound repair; non-core. Supporting Evidence: PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. |
| GO:0097060 synaptic membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to synaptic membrane (GO:0097060) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse (synaptic membrane); neural, non-core. |
| GO:0097386 glial cell projection | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to glial cell projection (GO:0097386) from GO_REF:0000024; with/from UniProtKB:P49134. Reason: ISS from rat beta1 (oligodendroglial beta1) for glial cell projection; non-core. |
| GO:0098609 cell-cell adhesion | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation of ITGB1 to cell-cell adhesion (GO:0098609) from GO_REF:0000033; with/from MGI:MGI:96611, MGI:MGI:96612, PANTHER:PTN000801545, RGD:1305581. Reason: PAINT IBA for cell-cell adhesion on the integrin beta node. Beta1 does mediate cell-cell adhesion through counter-receptors (VCAM1, ADAMs), but its core function is cell-matrix adhesion. Supporting Evidence: PMID:1715889 indicating that VLA-4/VCAM-1 interactions are important in adhesion of B cell precursors to the bone marrow microenvironment |
| GO:0098639 collagen binding involved in cell-matrix adhesion | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation of ITGB1 to collagen binding involved in cell-matrix adhesion (GO:0098639) from GO_REF:0000033; with/from PANTHER:PTN002560762, UniProtKB:P05556. Reason: PAINT IBA for collagen binding involved in cell-matrix adhesion on the beta1 node (human beta1 as seed). Alpha1, 2, 10, 11 beta1 heterodimers are the collagen receptors. Supporting Evidence: PMID:24823363 by specifically decreasing the binding of integrins Ξ±10Ξ²1 and Ξ±11Ξ²1 to arginine-containing motifs, such as GFOGER |
| GO:0098639 collagen binding involved in cell-matrix adhesion | IMP PMID:24823363 Citrullination of collagen II affects integrin-mediated cell... | ACCEPT | Summary: IMP annotation of ITGB1 to collagen binding involved in cell-matrix adhesion (GO:0098639) from PMID:24823363. Reason: Loss of collagen arginine (citrullination) reduces alpha10beta1/alpha11beta1 binding to GFOGER-type motifs and cell adhesion; collagen binding in cell-matrix adhesion. Supporting Evidence: PMID:24823363 by specifically decreasing the binding of integrins Ξ±10Ξ²1 and Ξ±11Ξ²1 to arginine-containing motifs, such as GFOGER |
| GO:0098640 integrin binding involved in cell-matrix adhesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to integrin binding involved in cell-matrix adhesion (GO:0098640) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer of integrin binding involved in cell-matrix adhesion; for beta1 the bound integrin is its alpha partner. Valid, non-core. |
| GO:0098640 integrin binding involved in cell-matrix adhesion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to integrin binding involved in cell-matrix adhesion (GO:0098640) from GO_REF:0000024; with/from UniProtKB:P09055. Reason: ISS from mouse beta1; as for the IEA row. |
| GO:0098685 Schaffer collateral - CA1 synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to Schaffer collateral - CA1 synapse (GO:0098685) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse of a specific synapse type; beta1 integrins act at synapses. Neural, non-core. |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to glutamatergic synapse (GO:0098978) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse of a specific synapse type; beta1 integrins act at synapses. Neural, non-core. |
| GO:0150003 regulation of spontaneous synaptic transmission | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to regulation of spontaneous synaptic transmission (GO:0150003) from GO_REF:0000024; with/from UniProtKB:P09055. Reason: ISS from mouse beta1 (negative effect on spontaneous synaptic transmission); neural, non-core. |
| GO:0150053 cerebellar climbing fiber to Purkinje cell synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to cerebellar climbing fiber to Purkinje cell synapse (GO:0150053) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse of a specific synapse type; beta1 integrins act at synapses. Neural, non-core. |
| GO:0150103 reactive gliosis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation of ITGB1 to reactive gliosis (GO:0150103) from GO_REF:0000024; with/from UniProtKB:P09055. Reason: ISS from mouse beta1 (negative effect on reactive gliosis); glial, non-core. |
| GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway | IDA PMID:24044949 MicroRNA-223 antagonizes angiogenesis by targeting Ξ²1 integr... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to positive regulation of vascular endothelial growth factor signaling pathway (GO:1900748) from PMID:24044949. Reason: Beta1 re-expression rescues VEGF receptor phosphorylation in miR-223 overexpressing endothelial cells. Context-specific. Supporting Evidence: PMID:24044949 Reintroduction of Ξ²1 integrin into miR-223-ovexpressing cells was sufficient to rescue growth factor signaling and angiogenesis. |
| GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to positive regulation of vascular endothelial growth factor signaling pathway (GO:1900748) from GO_REF:0000117; with/from ARBA:ARBA00085719. Reason: ARBA prediction consistent with the IDA row for VEGF receptor signalling. Non-core. Supporting Evidence: PMID:24044949 Reintroduction of Ξ²1 integrin into miR-223-ovexpressing cells was sufficient to rescue growth factor signaling and angiogenesis. |
| GO:1903078 positive regulation of protein localization to plasma membrane | IDA PMID:10455171 A novel protease-docking function of integrin at invadopodia... | KEEP AS NON CORE | Summary: IDA annotation of ITGB1 to positive regulation of protein localization to plasma membrane (GO:1903078) from PMID:10455171. Reason: Collagen-induced alpha3beta1 docking concentrates seprase at invadopodial plasma membrane. Specialised, non-core. Supporting Evidence: PMID:10455171 The results show that alpha(3)beta(1) integrin is a docking protein for seprase to form functional invadopodia. |
| GO:1905806 regulation of synapse pruning | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation of ITGB1 to regulation of synapse pruning (GO:1905806) from GO_REF:0000107; with/from UniProtKB:P09055, ensembl:ENSMUSP00000087457. Reason: Ensembl transfer from mouse (regulation of synapse pruning); neural, non-core. |
| GO:1990782 protein tyrosine kinase binding | IPI PMID:26763945 Focal Adhesion Kinase Regulates Fibroblast Migration via Int... | KEEP AS NON CORE | Summary: IPI annotation of ITGB1 to protein tyrosine kinase binding (GO:1990782) from PMID:26763945; with/from UniProtKB:Q05397. Reason: FAK (Q05397) is directly recruited by integrin beta1; protein tyrosine kinase binding is valid but downstream of the core receptor activity. Supporting Evidence: PMID:26763945 The data indicate that FAK is directly recruited by integrin Ξ²1 and the subsequent FAK activation is required for fibroblast migration on fibronectin. |
| GO:2000811 negative regulation of anoikis | IMP PMID:15006356 A mitochondrial protein, Bit1, mediates apoptosis regulated ... | KEEP AS NON CORE | Summary: IMP annotation of ITGB1 to negative regulation of anoikis (GO:2000811) from PMID:15006356. Reason: Cell attachment to fibronectin counteracts Bit1/AES-mediated anoikis; beta1 adhesion signals survival. Context-specific. Supporting Evidence: PMID:15006356 Cell attachment to fibronectin counteracts the apoptotic effect of Bit1 and AES. |
Loading supporting contentβ¦
Download this section (compressed HTML)Q: Capsaspora has four integrin beta paralogs from a lineage-specific expansion. Which of them, if any, bind the Capsaspora talin FERM head through their NPxY motifs, and which native Capsaspora ligand do they bind in place of fibronectin?
Q: Did the ancestral holozoan integrin beta already use divalent-cation (MIDAS/ADMIDAS) dependent ligand binding, given that these sites are conserved in Capsaspora beta1-3 but not beta4?
Q: Choanoflagellates lost integrins. What, if anything, replaced integrin-mediated substrate adhesion in that lineage, and what do its retained talin and vinculin homologs do?
Q: Should integrin-family IBA process terms such as cell-cell adhesion and synapse (PTN000801545, PTN002560762) be placed on nodes restricted to animals, given that the pre-metazoan evidence supports only cell-substrate adhesion?
Experiment: Express Capsaspora integrin beta1-3 (with or without their NPxY motifs) in ITGB1-null mammalian fibroblasts with a matched alpha subunit and test surface expression, adhesion and spreading on fibronectin, collagen and laminin, and talin recruitment.
Type: Cross-species complementation
Experiment: Use Capsaspora integrin beta2 ectodomain pull-downs from Capsaspora secreted material and cation (Mn2+/EDTA) dependence to identify the native substrate ligand used during the adherent stage.
Type: Ligand identification
Loading supporting contentβ¦
Download this section (compressed HTML)Loading supporting contentβ¦
Download this section (compressed HTML)