ITPR1 encodes inositol 1,4,5-trisphosphate receptor type 1, a large multi-pass endoplasmic-reticulum membrane protein that assembles as a homotetramer to form an IP3-gated calcium release channel. Binding of IP3 (generated by phospholipase C downstream of many surface receptors), together with calcium, opens the channel and releases Ca2+ from ER stores into the cytosol, shaping calcium signals that control processes from fertilization and secretion to synaptic signaling, autophagy, ER-mitochondria calcium transfer and apoptosis. It also localizes to the nuclear envelope and sarcoplasmic reticulum.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000902 cell morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cell morphogenesis. Reason: Ca2+ signaling role in morphogenesis; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0001666 response to hypoxia | IDA PMID:19120137 Hypoxia differently modulates gene expression of inositol 1,... | KEEP AS NON CORE | Summary: Response to hypoxia. Reason: ITPR1 participates in hypoxic Ca2+ responses; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0001666 response to hypoxia | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Response to hypoxia. Reason: ITPR1 participates in hypoxic Ca2+ responses; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0005216 monoatomic ion channel activity | IEA GO_REF:0000002 | TOO GENERAL | Summary: Monoatomic ion channel activity. Reason: Entailed by the asserted calcium channel activity. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IBA GO_REF:0000033 | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/IMP; IP3 binding opens the ER Ca2+ channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IDA PMID:10620513 Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2... | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/IMP; IP3 binding opens the ER Ca2+ channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IDA PMID:36376291 Conformational motions and ligand-binding underlying gating ... | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/IMP; IP3 binding opens the ER Ca2+ channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IEA GO_REF:0000120 | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/IMP; IP3 binding opens the ER Ca2+ channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IMP PMID:27108797 Recessive and Dominant De Novo ITPR1 Mutations Cause Gillesp... | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/IMP; IP3 binding opens the ER Ca2+ channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | ISS GO_REF:0000024 | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/IMP; IP3 binding opens the ER Ca2+ channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | TAS PMID:8648241 Induction of inositol 1,4,5 trisphosphate receptor genes by ... | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/IMP; IP3 binding opens the ER Ca2+ channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005262 calcium channel activity | IEA GO_REF:0000002 | TOO GENERAL | Summary: Calcium channel activity. Reason: Entailed by the asserted IP3-gated calcium channel activity. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005509 calcium ion binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Calcium ion binding. Reason: Ca2+ binds and regulates channel gating; non-core regulatory property. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:16793548 IRBIT suppresses IP3 receptor activity by competing with IP3... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:19220705 An IRBIT homologue lacks binding activity to inositol 1,4,5-... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:19220705 An IRBIT homologue lacks binding activity to inositol 1,4,5-... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:20010695 Antagonism of Beclin 1-dependent autophagy by BCL-2 at the e... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:22045699 The homocysteine-inducible endoplasmic reticulum (ER) stress... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:23884412 The Bcl-2 protein family member Bok binds to the coupling do... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:27995898 IRBIT controls apoptosis by interacting with the Bcl-2 homol... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:27995898 IRBIT controls apoptosis by interacting with the Bcl-2 homol... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by IP3/PI binding, domain-specific binding and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005635 nuclear envelope | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Nuclear envelope. Reason: ITPR1 resides in the nuclear envelope, continuous with the ER; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005637 nuclear inner membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Nuclear inner membrane. Reason: Part of the nuclear-envelope ER-continuous pool; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005730 nucleolus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Nucleolus. Reason: A reported localization; peripheral to the ER channel function. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005737 cytoplasm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cytoplasm. Reason: Broad cytoplasmic assignment; the functional membrane is the ER. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005783 endoplasmic reticulum | IDA PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ... | TOO GENERAL | Summary: Endoplasmic reticulum. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005783 endoplasmic reticulum | IEA GO_REF:0000120 | TOO GENERAL | Summary: Endoplasmic reticulum. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005783 endoplasmic reticulum | ISS GO_REF:0000024 | TOO GENERAL | Summary: Endoplasmic reticulum. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005783 endoplasmic reticulum | NAS PMID:8648241 Induction of inositol 1,4,5 trisphosphate receptor genes by ... | TOO GENERAL | Summary: Endoplasmic reticulum. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR1; a multi-pass ER-membrane channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IDA PMID:27108798 A Restricted Repertoire of De Novo Mutations in ITPR1 Cause ... | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR1; a multi-pass ER-membrane channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IDA PMID:7852357 The human type 1 inositol 1,4,5-trisphosphate receptor from ... | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR1; a multi-pass ER-membrane channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IEA GO_REF:0000120 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR1; a multi-pass ER-membrane channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-1168376 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR1; a multi-pass ER-membrane channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-381644 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR1; a multi-pass ER-membrane channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-5226904 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR1; a multi-pass ER-membrane channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IP3 receptors are functionally present in the plasma membrane of B cells as a very small pool (about two channels per cell) that carries part of B-cell-receptor-evoked Ca2+ entry; the bulk of ITPR1 is in the ER membrane. Reason: The IBA places plasma membrane at the IP3R family node, consistent with patch-clamp evidence that IP3Rs are also functionally expressed at the plasma membrane of DT40 and mouse B cells, with a pore-adjacent engineered site reachable from outside the cell. The cached abstracts do not state which IP3R subtype was assayed; in human platelets, type I IP3R is intracellular while type III is the plasma-membrane subtype. A plasma-membrane pool of ITPR1 is therefore plausible but minor, cell-type restricted and not established for this subtype, so it is non-core rather than removed. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane PMID:16840702 IP3 stimulated opening of very few (1.9 +/- 0.2 per cell) Ca2+-permeable channels in whole-cell patch-clamp recording of DT40 chicken or mouse B cells PMID:16840702 IP(3)Rs are unusual among endoplasmic reticulum proteins in being also functionally expressed at the PM PMID:10828023 The PM fractions were found to contain the type III (1,4,5)IP(3)R and GAP1(IP4BP) in contrast to IM, which contained type I (1,4,5)IP(3)R |
| GO:0005955 calcineurin complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Calcineurin complex. Reason: Association with calcineurin signaling; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0006811 monoatomic ion transport | IEA GO_REF:0000002 | TOO GENERAL | Summary: Monoatomic ion transport. Reason: Entailed by the asserted calcium ion transmembrane transport. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0006816 calcium ion transport | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Calcium ion transport. Reason: General parent of the ER Ca2+ release it mediates; retained as non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0006816 calcium ion transport | NAS PMID:7852357 The human type 1 inositol 1,4,5-trisphosphate receptor from ... | KEEP AS NON CORE | Summary: Calcium ion transport. Reason: General parent of the ER Ca2+ release it mediates; retained as non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0007165 signal transduction | NAS PMID:8648241 Induction of inositol 1,4,5 trisphosphate receptor genes by ... | TOO GENERAL | Summary: Signal transduction. Reason: Entailed by the more specific calcium-mediated signaling role. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PLC-activating GPCR signaling pathway. Reason: ITPR1 acts downstream of PLC-generated IP3; non-core participation. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: PLC-activating GPCR signaling pathway. Reason: ITPR1 acts downstream of PLC-generated IP3; non-core participation. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: PLC-activating muscarinic acetylcholine receptor signaling. Reason: ITPR1 acts downstream of IP3 generated by this pathway; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0007338 single fertilization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Single fertilization. Reason: ITPR1-driven Ca2+ oscillations at fertilization; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0007338 single fertilization | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Single fertilization. Reason: ITPR1-driven Ca2+ oscillations at fertilization; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0010506 regulation of autophagy | TAS PMID:22770472 Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-relea... | KEEP AS NON CORE | Summary: Regulation of autophagy. Reason: ITPR1 Ca2+ signaling modulates autophagy; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0014069 postsynaptic density | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Postsynaptic density. Reason: ITPR1 localizes near postsynaptic ER in neurons; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0015085 calcium ion transmembrane transporter activity | IEA GO_REF:0000117 | TOO GENERAL | Summary: Calcium ion transmembrane transporter activity. Reason: Entailed by the asserted IP3-gated calcium channel activity (a channel is a transporter). Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0015085 calcium ion transmembrane transporter activity | TAS PMID:7500840 Molecular cloning of a cDNA for the human inositol 1,4,5-tri... | TOO GENERAL | Summary: Calcium ion transmembrane transporter activity. Reason: Entailed by the asserted IP3-gated calcium channel activity (a channel is a transporter). Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0015278 intracellularly gated calcium channel activity | IEA GO_REF:0000107 | TOO GENERAL | Summary: Intracellularly gated calcium channel activity. Reason: Entailed by the asserted, more specific IP3-gated calcium channel activity. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0015278 intracellularly gated calcium channel activity | ISS GO_REF:0000024 | TOO GENERAL | Summary: Intracellularly gated calcium channel activity. Reason: Entailed by the asserted, more specific IP3-gated calcium channel activity. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0016020 membrane | HDA PMID:19946888 Defining the membrane proteome of NK cells. | TOO GENERAL | Summary: Membrane. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0016020 membrane | IEA GO_REF:0000002 | TOO GENERAL | Summary: Membrane. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0016529 sarcoplasmic reticulum | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Sarcoplasmic reticulum. Reason: The muscle equivalent of the ER store; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0016529 sarcoplasmic reticulum | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Sarcoplasmic reticulum. Reason: The muscle equivalent of the ER store; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0019722 calcium-mediated signaling | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Calcium-mediated signaling. Reason: ITPR1 Ca2+ release drives Ca2+ signaling; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0019855 calcium channel inhibitor activity | IDA PMID:16793548 IRBIT suppresses IP3 receptor activity by competing with IP3... | MARK AS OVER ANNOTATED | Summary: Calcium channel inhibitor activity. Reason: The cited study shows IRBIT inhibits the IP3 receptor by competing for the IP3 site; the inhibitor activity belongs to the partner, not to ITPR1 itself, so this over-annotates the channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Protein domain specific binding. Reason: ITPR1 engages partner domains in its signaling complexes; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0030658 transport vesicle membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Transport vesicle membrane. Reason: Reported vesicular-membrane pool; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0030667 secretory granule membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Secretory granule membrane. Reason: Reported granule-membrane pool; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031088 platelet dense granule membrane | IDA PMID:10828023 Distinct localization and function of (1,4,5)IP(3) receptor ... | KEEP AS NON CORE | Summary: Platelet dense granule membrane. Reason: Platelet Ca2+-store membrane localization; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031094 platelet dense tubular network | IDA PMID:10828023 Distinct localization and function of (1,4,5)IP(3) receptor ... | KEEP AS NON CORE | Summary: Platelet dense tubular network. Reason: Platelet ER-equivalent Ca2+ store; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031095 platelet dense tubular network membrane | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Platelet dense tubular network membrane. Reason: Platelet ER-equivalent store membrane; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031095 platelet dense tubular network membrane | TAS Reactome:R-HSA-139854 | KEEP AS NON CORE | Summary: Platelet dense tubular network membrane. Reason: Platelet ER-equivalent store membrane; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031095 platelet dense tubular network membrane | TAS Reactome:R-HSA-139941 | KEEP AS NON CORE | Summary: Platelet dense tubular network membrane. Reason: Platelet ER-equivalent store membrane; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031095 platelet dense tubular network membrane | TAS Reactome:R-HSA-418442 | KEEP AS NON CORE | Summary: Platelet dense tubular network membrane. Reason: Platelet ER-equivalent store membrane; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0032991 protein-containing complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Protein-containing complex. Reason: Generic complex membership; the specific functional unit is the homotetrameric channel. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0035091 phosphatidylinositol binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Phosphatidylinositol binding. Reason: Regulatory lipid binding; non-core relative to IP3 recognition. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt inositol 1,4,5-trisphosphate binding |
| GO:0035091 phosphatidylinositol binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Phosphatidylinositol binding. Reason: Regulatory lipid binding; non-core relative to IP3 recognition. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt inositol 1,4,5-trisphosphate binding |
| GO:0035091 phosphatidylinositol binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Phosphatidylinositol binding. Reason: Regulatory lipid binding; non-core relative to IP3 recognition. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt inositol 1,4,5-trisphosphate binding |
| GO:0036398 TCR signalosome | IDA PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ... | KEEP AS NON CORE | Summary: TCR signalosome. Reason: ITPR1 is recruited to T-cell receptor Ca2+ signaling complexes; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0036444 calcium import into the mitochondrion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Calcium import into the mitochondrion. Reason: ITPR1 feeds ER-to-mitochondria Ca2+ transfer at MAMs; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0042045 epithelial fluid transport | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Epithelial fluid transport. Reason: ITPR1 (via AHCYL1) regulates epithelial electrolyte/fluid secretion; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Involved in the regulation of epithelial |
| GO:0042803 protein homodimerization activity | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Protein homodimerization activity. Reason: Reflects ITPR1 self-association; the functional unit is a homotetramer. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0043065 positive regulation of apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of apoptotic process. Reason: ITPR1-mediated Ca2+ release can promote apoptosis; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0045202 synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Synapse. Reason: Neuronal synaptic ER localization; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Perinuclear region of cytoplasm. Reason: Perinuclear ER localization; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0050848 regulation of calcium-mediated signaling | IDA PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ... | KEEP AS NON CORE | Summary: Regulation of calcium-mediated signaling. Reason: ITPR1 modulates Ca2+ signaling; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0050849 negative regulation of calcium-mediated signaling | IDA PMID:16793548 IRBIT suppresses IP3 receptor activity by competing with IP3... | KEEP AS NON CORE | Summary: Negative regulation of calcium-mediated signaling. Reason: Context-dependent dampening of Ca2+ signaling; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0051209 release of sequestered calcium ion into cytosol | IBA GO_REF:0000033 | ACCEPT | Summary: Release of sequestered calcium ion into cytosol. Reason: Core output of IP3R gating (ER Ca2+ release). Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0051209 release of sequestered calcium ion into cytosol | IDA PMID:10620513 Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2... | ACCEPT | Summary: Release of sequestered calcium ion into cytosol. Reason: Core output of IP3R gating (ER Ca2+ release). Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0051209 release of sequestered calcium ion into cytosol | IEA GO_REF:0000107 | ACCEPT | Summary: Release of sequestered calcium ion into cytosol. Reason: Core output of IP3R gating (ER Ca2+ release). Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0051209 release of sequestered calcium ion into cytosol | ISS GO_REF:0000024 | ACCEPT | Summary: Release of sequestered calcium ion into cytosol. Reason: Core output of IP3R gating (ER Ca2+ release). Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0051289 protein homotetramerization | IEA GO_REF:0000107 | ACCEPT | Summary: Protein homotetramerization. Reason: Functional IP3 receptors are homotetramers forming the channel pore. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0051289 protein homotetramerization | ISS GO_REF:0000024 | ACCEPT | Summary: Protein homotetramerization. Reason: Functional IP3 receptors are homotetramers forming the channel pore. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0051289 protein homotetramerization | ISS GO_REF:0000024 | ACCEPT | Summary: Protein homotetramerization. Reason: Functional IP3 receptors are homotetramers forming the channel pore. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0051480 regulation of cytosolic calcium ion concentration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Regulation of cytosolic calcium ion concentration. Reason: ITPR1 release shapes cytosolic Ca2+; non-core regulatory process. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0051480 regulation of cytosolic calcium ion concentration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of cytosolic calcium ion concentration. Reason: ITPR1 release shapes cytosolic Ca2+; non-core regulatory process. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0055085 transmembrane transport | IEA GO_REF:0000002 | TOO GENERAL | Summary: Transmembrane transport. Reason: Entailed by the asserted calcium ion transmembrane transport. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Intrinsic apoptotic signaling in response to ER stress. Reason: ER Ca2+ release by ITPR1 contributes to ER-stress apoptosis; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Intrinsic apoptotic signaling in response to ER stress. Reason: ER Ca2+ release by ITPR1 contributes to ER-stress apoptosis; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0070588 calcium ion transmembrane transport | IEA GO_REF:0000002 | ACCEPT | Summary: Calcium ion transmembrane transport. Reason: ITPR1 conducts Ca2+ across the ER membrane; core transport process. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:0070679 inositol 1,4,5 trisphosphate binding | IBA GO_REF:0000033 | ACCEPT | Summary: Inositol 1,4,5-trisphosphate binding. Reason: The ligand-binding activity that gates the channel; core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt inositol 1,4,5-trisphosphate binding |
| GO:0070679 inositol 1,4,5 trisphosphate binding | IEA GO_REF:0000120 | ACCEPT | Summary: Inositol 1,4,5-trisphosphate binding. Reason: The ligand-binding activity that gates the channel; core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt inositol 1,4,5-trisphosphate binding |
| GO:0070679 inositol 1,4,5 trisphosphate binding | ISS GO_REF:0000024 | ACCEPT | Summary: Inositol 1,4,5-trisphosphate binding. Reason: The ligand-binding activity that gates the channel; core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt inositol 1,4,5-trisphosphate binding |
| GO:0098685 Schaffer collateral - CA1 synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Schaffer collateral - CA1 synapse. Reason: Specific hippocampal synaptic localization; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Endoplasmic reticulum membrane |
| GO:0098695 inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IP3 receptor activity in postsynaptic cytosolic calcium regulation. Reason: A synapse-specific framing of the core channel activity; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration | IEA GO_REF:0000108 | KEEP AS NON CORE | Summary: Regulation of postsynaptic cytosolic calcium concentration. Reason: Synaptic Ca2+ regulation by ITPR1; non-core. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
| GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum | IDA PMID:36376291 Conformational motions and ligand-binding underlying gating ... | ACCEPT | Summary: Release of sequestered calcium from the ER into the cytosol. Reason: The core physiological output of ITPR1 channel opening. Supporting Evidence: file:human/ITPR1/ITPR1-uniprot.txt mediates calcium release from the |
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Download this section (compressed HTML)Q: How do the four IP3R1 subunits cooperate and how does Ca2+ act as both co-agonist and inhibitor to produce calcium oscillations?
Q: Which ITPR1 interactions (IRBIT/AHCYL1, Bcl-2 family, at MAMs) set the threshold between physiological Ca2+ signaling and apoptotic ER Ca2+ release?
Experiment: Cryo-EM of human ITPR1 in closed and IP3/Ca2+-bound open states to define the gating mechanism.
Type: structural biology
Experiment: ER-targeted Ca2+ sensors in ITPR1-null cells reconstituted with gating mutants to map IP3- and Ca2+-dependence of release.
Type: cell biology
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