ITPR3 encodes inositol 1,4,5-trisphosphate receptor type 3, a multi-pass endoplasmic-reticulum membrane protein that forms a homotetrameric IP3-gated calcium release channel. IP3 binding, with calcium as co-agonist, opens the channel to transport Ca2+ from the ER lumen to the cytosol, shaping calcium signals for processes including taste transduction, platelet activation, secretion and broad cellular calcium homeostasis. ITPR3 is enriched in the apical ER of polarized epithelial and taste cells.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000822 inositol hexakisphosphate binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Inositol hexakisphosphate (IP6) binding. Reason: Regulatory inositol-polyphosphate binding; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt 1D-myo-inositol 1,4,5-trisphosphate binding |
| GO:0005216 monoatomic ion channel activity | IEA GO_REF:0000002 | TOO GENERAL | Summary: Monoatomic ion channel activity. Reason: Entailed by the asserted calcium channel activity. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IBA GO_REF:0000033 | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/structural studies; IP3 gates ER Ca2+ release. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IDA PMID:10828023 Distinct localization and function of (1,4,5)IP(3) receptor ... | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/structural studies; IP3 gates ER Ca2+ release. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IDA PMID:30013099 Structural basis for the regulation of inositol trisphosphat... | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/structural studies; IP3 gates ER Ca2+ release. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IDA PMID:37898605 Structural titration reveals Ca(2+)-dependent conformational... | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/structural studies; IP3 gates ER Ca2+ release. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | IEA GO_REF:0000120 | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/structural studies; IP3 gates ER Ca2+ release. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | ISS GO_REF:0000024 | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/structural studies; IP3 gates ER Ca2+ release. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity | ISS GO_REF:0000024 | ACCEPT | Summary: IP3-gated calcium release channel activity. Reason: The defining molecular function, supported by IDA/structural studies; IP3 gates ER Ca2+ release. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005262 calcium channel activity | IEA GO_REF:0000002 | TOO GENERAL | Summary: Calcium channel activity. Reason: Entailed by the asserted IP3-gated calcium channel activity. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005509 calcium ion binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Calcium ion binding. Reason: Ca2+ acts as co-agonist/regulator of gating; non-core regulatory property. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005509 calcium ion binding | IDA PMID:37898605 Structural titration reveals Ca(2+)-dependent conformational... | KEEP AS NON CORE | Summary: Calcium ion binding. Reason: Ca2+ acts as co-agonist/regulator of gating; non-core regulatory property. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:10611319 Modulation of Ca(2+) entry by polypeptides of the inositol 1... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:19052258 Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:19052258 Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:19553469 Human Golgi antiapoptotic protein modulates intracellular ca... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:21062895 Agonist-activated Ca2+ influx occurs at stable plasma membra... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:25996873 TMEM203 Is a Novel Regulator of Intracellular Calcium Homeos... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:28614305 BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria su... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005515 protein binding | IPI PMID:30042492 STAT3 localizes to the ER, acting as a gatekeeper for ER-mit... | REMOVE | Summary: Generic protein binding. Reason: Bare protein binding is uninformative and removed under the protein-binding policy; informative binding is captured by the inositol-phosphate/PI binding terms and homotetramerization; removal does not dispute the interactions. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005524 ATP binding | IDA PMID:37898605 Structural titration reveals Ca(2+)-dependent conformational... | KEEP AS NON CORE | Summary: ATP binding. Reason: ATP modulates IP3R gating; non-core regulatory property. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0005634 nucleus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Nucleus. Reason: Nuclear-envelope ER-continuous pool; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005640 nuclear outer membrane | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Nuclear outer membrane. Reason: ER-continuous nuclear-envelope membrane; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005654 nucleoplasm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Nucleoplasm. Reason: Reported nuclear localization; peripheral to the ER channel role. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005730 nucleolus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Nucleolus. Reason: Reported localization; peripheral. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005737 cytoplasm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cytoplasm. Reason: Broad cytoplasmic assignment; the functional membrane is the ER. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Cytoplasm. Reason: Broad cytoplasmic assignment; the functional membrane is the ER. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005783 endoplasmic reticulum | IEA GO_REF:0000002 | TOO GENERAL | Summary: Endoplasmic reticulum. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005783 endoplasmic reticulum | ISS GO_REF:0000024 | TOO GENERAL | Summary: Endoplasmic reticulum. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IDA PMID:21062895 Agonist-activated Ca2+ influx occurs at stable plasma membra... | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IEA GO_REF:0000120 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IMP PMID:39270020 A pleiotropic recurrent dominant ITPR3 variant causes a comp... | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | IMP PMID:39560673 Dominant negative variants in ITPR3 impair T cell Ca2+ dynam... | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | ISS GO_REF:0000024 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-1168376 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-381644 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-5226904 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-9717214 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-9717215 | ACCEPT | Summary: Endoplasmic reticulum membrane. Reason: The principal site of ITPR3; an ER-membrane channel. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Plasma membrane pool. Among the IP3R subtypes, type III is the one found at the plasma membrane, so the family-node IBA is well supported for ITPR3 specifically; the bulk of ITPR3 is still ER membrane. Reason: The IBA places plasma membrane at the IP3R family node. For ITPR3 this is corroborated by subtype-specific evidence, since in human platelets the type III IP3R is the plasma-membrane, surface-biotinylated subtype (PMID:10828023). It remains minor relative to the ER channel, so non-core. Supporting Evidence: PMID:10828023 The PM fractions were found to contain the type III (1,4,5)IP(3)R and GAP1(IP4BP) in contrast to IM, which contained type I (1,4,5)IP(3)R |
| GO:0005886 plasma membrane | IDA PMID:10828023 Distinct localization and function of (1,4,5)IP(3) receptor ... | KEEP AS NON CORE | Summary: Plasma membrane of human platelets, shown by surface biotinylation and immunogold of the type III subtype specifically. Reason: Direct evidence (surface biotinylation of intact platelets, immunogold of the platelet plasma membrane) that the type III IP3R is the surface-exposed subtype. The part_of platelet extension records that this surface pool is the cell-type-restricted context. A genuine plasma-membrane pool, but minor relative to the ER channel, so non-core. Supporting Evidence: PMID:10828023 In studies examining the labeling of surface proteins with biotin in intact platelets only the type III (1,4,5)IP(3)R was significantly labeled |
| GO:0005886 plasma membrane | IDA PMID:21062895 Agonist-activated Ca2+ influx occurs at stable plasma membra... | KEEP AS NON CORE | Summary: Pool of ITPR3 at ER-plasma-membrane peripheral junctions, where agonist-activated Ca2+ entry occurs; shown by TIRF microscopy in HEK293 cells whose major IP3R is type III. Reason: TIRF microscopy localises a fraction of type III IP3R to a domain immediately adjacent to the plasma membrane at junctate/TRPC3 ER-PM junctions, the anatomical site of agonist-activated Ca2+ entry. A junctional/peripheral pool rather than the bulk ER channel, so non-core. Supporting Evidence: PMID:21062895 These results indicate that a small percentage of junctate and Ins P 3 R3 colocalize in a domain closely adjacent to the PM |
| GO:0005903 brush border | ISS PMID:8288584 Primary structure, ligand binding, and localization of the h... | KEEP AS NON CORE | Summary: Brush border. Reason: Apical/brush-border ER enrichment in epithelia; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0006811 monoatomic ion transport | IEA GO_REF:0000002 | TOO GENERAL | Summary: Monoatomic ion transport. Reason: Entailed by the asserted calcium ion transmembrane transport. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0006816 calcium ion transport | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Calcium ion transport. Reason: General parent of the ER Ca2+ release it mediates; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0007186 G protein-coupled receptor signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: G protein-coupled receptor signaling pathway. Reason: ITPR3 acts downstream of GPCR/PLC-generated IP3; non-core participation. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PLC-activating GPCR signaling pathway. Reason: ITPR3 acts downstream of PLC-generated IP3; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0007204 positive regulation of cytosolic calcium ion concentration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of cytosolic calcium ion concentration. Reason: ITPR3 release raises cytosolic Ca2+; non-core regulatory process. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0008270 zinc ion binding | IDA PMID:37898605 Structural titration reveals Ca(2+)-dependent conformational... | KEEP AS NON CORE | Summary: Zinc ion binding. Reason: Structural Zn binding; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0015278 intracellularly gated calcium channel activity | IEA GO_REF:0000107 | TOO GENERAL | Summary: Intracellularly gated calcium channel activity. Reason: Entailed by the asserted, more specific IP3-gated calcium channel activity. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0015278 intracellularly gated calcium channel activity | IMP PMID:39560673 Dominant negative variants in ITPR3 impair T cell Ca2+ dynam... | TOO GENERAL | Summary: Intracellularly gated calcium channel activity. Reason: Entailed by the asserted, more specific IP3-gated calcium channel activity. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0015278 intracellularly gated calcium channel activity | ISS GO_REF:0000024 | TOO GENERAL | Summary: Intracellularly gated calcium channel activity. Reason: Entailed by the asserted, more specific IP3-gated calcium channel activity. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0015278 intracellularly gated calcium channel activity | TAS Reactome:R-HSA-9717215 | TOO GENERAL | Summary: Intracellularly gated calcium channel activity. Reason: Entailed by the asserted, more specific IP3-gated calcium channel activity. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0016020 membrane | HDA PMID:19946888 Defining the membrane proteome of NK cells. | TOO GENERAL | Summary: Membrane. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0016020 membrane | IEA GO_REF:0000002 | TOO GENERAL | Summary: Membrane. Reason: Entailed by the asserted ER membrane localization. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0016529 sarcoplasmic reticulum | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Sarcoplasmic reticulum. Reason: Muscle ER-equivalent store; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0019722 calcium-mediated signaling | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Calcium-mediated signaling. Reason: ITPR3 Ca2+ release drives Ca2+ signaling; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0030168 platelet activation | IDA PMID:10828023 Distinct localization and function of (1,4,5)IP(3) receptor ... | KEEP AS NON CORE | Summary: Platelet activation. Reason: ITPR3-mediated Ca2+ release contributes to platelet activation; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0030658 transport vesicle membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Transport vesicle membrane. Reason: Reported vesicular pool; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0030667 secretory granule membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Secretory granule membrane. Reason: Reported granule-membrane pool; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031095 platelet dense tubular network membrane | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Platelet dense tubular network membrane. Reason: Platelet ER-equivalent store membrane; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031095 platelet dense tubular network membrane | TAS Reactome:R-HSA-139854 | KEEP AS NON CORE | Summary: Platelet dense tubular network membrane. Reason: Platelet ER-equivalent store membrane; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0031095 platelet dense tubular network membrane | TAS Reactome:R-HSA-139941 | KEEP AS NON CORE | Summary: Platelet dense tubular network membrane. Reason: Platelet ER-equivalent store membrane; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0035091 phosphatidylinositol binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Phosphatidylinositol binding. Reason: Regulatory lipid binding; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt 1D-myo-inositol 1,4,5-trisphosphate binding |
| GO:0035091 phosphatidylinositol binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Phosphatidylinositol binding. Reason: Regulatory lipid binding; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt 1D-myo-inositol 1,4,5-trisphosphate binding |
| GO:0043025 neuronal cell body | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Neuronal cell body. Reason: Neuronal ER localization; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0043235 signaling receptor complex | IDA PMID:23382219 Structural basis for endosomal trafficking of diverse transm... | KEEP AS NON CORE | Summary: Signaling receptor complex. Reason: ITPR3 assembles into Ca2+-signaling receptor complexes; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Inositol 1,3,4,5-tetrakisphosphate (IP4) binding. Reason: Regulatory inositol-polyphosphate binding; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt 1D-myo-inositol 1,4,5-trisphosphate binding |
| GO:0045177 apical part of cell | ISS PMID:8288584 Primary structure, ligand binding, and localization of the h... | KEEP AS NON CORE | Summary: Apical part of cell. Reason: ITPR3 is enriched in apical ER of polarized epithelial/taste cells; non-core location. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0050909 sensory perception of taste | TAS Reactome:R-HSA-9717207 | KEEP AS NON CORE | Summary: Sensory perception of taste. Reason: ITPR3 is essential for taste transduction in type II taste cells; a tissue-specific downstream process. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0051209 release of sequestered calcium ion into cytosol | IBA GO_REF:0000033 | ACCEPT | Summary: Release of sequestered calcium ion into cytosol. Reason: Core output of IP3R3 gating (ER Ca2+ release). Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0051209 release of sequestered calcium ion into cytosol | IDA PMID:32949214 Dominant mutations in ITPR3 cause Charcot-Marie-Tooth diseas... | ACCEPT | Summary: Release of sequestered calcium ion into cytosol. Reason: Core output of IP3R3 gating (ER Ca2+ release). Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0051209 release of sequestered calcium ion into cytosol | IEA GO_REF:0000117 | ACCEPT | Summary: Release of sequestered calcium ion into cytosol. Reason: Core output of IP3R3 gating (ER Ca2+ release). Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0051289 protein homotetramerization | IDA PMID:37898605 Structural titration reveals Ca(2+)-dependent conformational... | ACCEPT | Summary: Protein homotetramerization. Reason: Functional IP3R3 channels are homotetramers forming the pore. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Inositol 1,4,5-trisphosphate-gated calcium channel that |
| GO:0051592 response to calcium ion | IDA PMID:19052258 Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to... | KEEP AS NON CORE | Summary: Response to calcium ion. Reason: ITPR3 gating responds to Ca2+; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0055074 calcium ion homeostasis | IMP PMID:32949214 Dominant mutations in ITPR3 cause Charcot-Marie-Tooth diseas... | KEEP AS NON CORE | Summary: Calcium ion homeostasis. Reason: ITPR3 contributes to cellular Ca2+ homeostasis; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0055074 calcium ion homeostasis | IMP PMID:39560673 Dominant negative variants in ITPR3 impair T cell Ca2+ dynam... | KEEP AS NON CORE | Summary: Calcium ion homeostasis. Reason: ITPR3 contributes to cellular Ca2+ homeostasis; non-core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0055085 transmembrane transport | IEA GO_REF:0000002 | TOO GENERAL | Summary: Transmembrane transport. Reason: Entailed by the asserted calcium ion transmembrane transport. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0070588 calcium ion transmembrane transport | IEA GO_REF:0000002 | ACCEPT | Summary: Calcium ion transmembrane transport. Reason: ITPR3 conducts Ca2+ across the ER membrane; core transport process. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt the endoplasmic reticulum lumen to cytoplasm |
| GO:0070679 inositol 1,4,5 trisphosphate binding | IBA GO_REF:0000033 | ACCEPT | Summary: Inositol 1,4,5-trisphosphate binding. Reason: The gating ligand-binding activity; core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt 1D-myo-inositol 1,4,5-trisphosphate binding |
| GO:0070679 inositol 1,4,5 trisphosphate binding | IDA PMID:8288584 Primary structure, ligand binding, and localization of the h... | ACCEPT | Summary: Inositol 1,4,5-trisphosphate binding. Reason: The gating ligand-binding activity; core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt 1D-myo-inositol 1,4,5-trisphosphate binding |
| GO:0070679 inositol 1,4,5 trisphosphate binding | IEA GO_REF:0000120 | ACCEPT | Summary: Inositol 1,4,5-trisphosphate binding. Reason: The gating ligand-binding activity; core. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt 1D-myo-inositol 1,4,5-trisphosphate binding |
| GO:0098554 cytoplasmic side of endoplasmic reticulum membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cytoplasmic side of the ER membrane. Reason: The regulatory/cytoplasmic face of the ER channel; non-core sub-localization. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
| GO:0098554 cytoplasmic side of endoplasmic reticulum membrane | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Cytoplasmic side of the ER membrane. Reason: The regulatory/cytoplasmic face of the ER channel; non-core sub-localization. Supporting Evidence: file:human/ITPR3/ITPR3-uniprot.txt Endoplasmic reticulum membrane |
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Download this section (compressed HTML)Q: What determines ITPR3 apical ER targeting in polarized epithelial and taste cells?
Q: How do IP3R3 homotetramers versus heterotetramers with IP3R1/2 differ in gating and physiological role?
Experiment: ER Ca2+ imaging in ITPR3-null taste and epithelial cells reconstituted with gating mutants to link channel properties to taste/secretory output.
Type: cell biology
Experiment: Cryo-EM of human ITPR3 across ligand states to define its IP3/Ca2+ gating trajectory.
Type: structural biology
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