JAK1 (Janus Kinase 1) is a non-receptor tyrosine kinase that plays a pivotal role in cytokine signal transduction. Contains four major domains: FERM domain for receptor binding, SH2-like domain for receptor interaction, pseudokinase domain for regulation, and active kinase domain for catalytic activity. Essential for Type I/II interferon signaling, IL-6 family cytokines, and Ξ³c-dependent cytokine pathways. Required for immune cell development, antiviral responses, and inflammatory processes. Mutations cause cancer (gain-of-function) or severe immunodeficiency (loss-of-function). Target of therapeutic JAK inhibitors.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Well-supported core molecular function - JAK1 is a non-receptor tyrosine kinase Reason: This is JAK1's primary molecular function, extensively validated by biochemical and functional studies. The IBA evidence is supported by direct experimental evidence. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md **JAK1** is an **intracellular, non-receptor tyrosine kinase** that operates as the receptor-proximal catalytic component of the **JAKβSTAT signaling pathway** |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IBA GO_REF:0000033 | ACCEPT | Summary: Core biological process - JAK1 is a central component of JAK-STAT signaling Reason: This is the canonical pathway mediated by JAK1. Essential for multiple cytokine receptor signaling cascades. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md **JAK1** is an **intracellular, non-receptor tyrosine kinase** that operates as the receptor-proximal catalytic component of the **JAKβSTAT signaling pathway**, transducing extracellular cytokine signals into transcriptional responses. |
| GO:0019221 cytokine-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Core biological process - JAK1 mediates signaling for multiple cytokine families Reason: JAK1 is required for Type I/II interferons, IL-6 family, and Ξ³c-dependent cytokines. This is a fundamental process for JAK1. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAK1 sits at key junctions for interferon, ILβ6 family, and multiple lymphocyte cytokine pathways. |
| GO:0035556 intracellular signal transduction | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Accurate but general biological process Reason: While accurate, this is too general. More specific cytokine signaling terms better describe JAK1's function. |
| GO:0030154 cell differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Valid downstream process mediated by JAK1-dependent cytokines Reason: JAK1 regulates cell differentiation indirectly through cytokine signaling (e.g., lymphocyte development via IL-7), but this is a downstream consequence rather than core function. |
| GO:0005131 growth hormone receptor binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Specific receptor interaction supported by experimental evidence Reason: JAK1 does bind growth hormone receptor, but this is one of many receptor interactions. Core function is broader tyrosine kinase activity. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Valid but less specific than protein tyrosine kinase activity Reason: Accurate but GO:0004715 (non-membrane spanning protein tyrosine kinase activity) is more specific and preferred. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core molecular function - accurate and specific Reason: This is JAK1's primary catalytic activity. Well-supported by extensive biochemical evidence. |
| GO:0005524 ATP binding | IEA GO_REF:0000120 | ACCEPT | Summary: Essential cofactor binding for kinase activity Reason: ATP binding is required for JAK1's tyrosine kinase activity. This is a core molecular function. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAK1's **JH1** domain is the active tyrosine kinase module. The same kinase-family analysis reports canonical active-site motif residues in JAK1's catalytic domain, including **K908** (N-lobe), **D1003** within the **HRD** motif, and **D1022** within the **DFG** motifβhallmarks of protein kinase catalysis and ATP-dependent phosphotransfer. |
| GO:0000166 nucleotide binding | IEA GO_REF:0000043 | REMOVE | Summary: Too general - ATP binding is more specific for kinase function Reason: While JAK1 does bind nucleotides, this term is overly general and uninformative. The more specific GO:0005524 (ATP binding) already captures JAK1's requirement for ATP as a cofactor for its tyrosine kinase activity. Per GO curation guidelines, overly general terms should be removed in favor of more specific functional annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research.md The kinase domain binds ATP and catalyzes the transfer of the Ξ³-phosphate to tyrosine residues on substrates |
| GO:0016301 kinase activity | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: Valid but less specific than protein tyrosine kinase activity Reason: Accurate but too general. More specific tyrosine kinase terms are preferred. |
| GO:0016740 transferase activity | IEA GO_REF:0000043 | REMOVE | Summary: Too general - represents broad enzyme class Reason: This is overly general and doesn't provide useful functional information about JAK1's specific role as a tyrosine kinase. |
| GO:0022407 regulation of cell-cell adhesion | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Downstream effect of JAK1 signaling in specific contexts Reason: While JAK1 can influence cell adhesion through downstream signaling, this is context-specific and not a core function. |
| GO:0046872 metal ion binding | IEA GO_REF:0000043 | REMOVE | Summary: General cofactor binding - not specific to JAK1 function Reason: Too general and not informative about JAK1's specific biological role. Many proteins bind metal ions. |
| GO:0005515 protein binding | IPI PMID:16273093 A quantitative protein interaction network for the ErbB rece... | REMOVE | Summary: General protein binding - lacks specificity per GO curation guidelines Reason: Generic protein binding annotations are removed per GO curation guidelines in favor of more specific functional terms. PMID:16273093 is a protein microarray study showing ErbB receptor interactions, but this doesn't provide specific functional information about JAK1's role. JAK1's specific receptor binding functions are better captured by terms like cytokine receptor binding. Supporting Evidence: PMID:16273093 A quantitative protein interaction network for the ErbB receptors using protein microarrays. |
| GO:0031730 CCR5 chemokine receptor binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Specific receptor binding interaction Reason: JAK1 can bind CCR5 chemokine receptor, but this is a specific interaction among many. Core function is broader tyrosine kinase activity. |
| GO:0035771 interleukin-4-mediated signaling pathway | NAS PMID:12574355 Human activation-induced cytidine deaminase is induced by IL... | ACCEPT | Summary: Specific cytokine pathway mediated by JAK1 supported by direct experimental evidence Reason: PMID:12574355 demonstrates that IL-4 induces AID expression via "IL-4-activated JAK1, JAK3, and STAT6 phosphorylations" providing direct evidence for JAK1's essential role in IL-4 signaling. Supporting Evidence: PMID:12574355 IL-4-dependent AID induction was inhibited by a dominant-negative STAT6, indicating that IL-4 induced AID expression via the Janus kinase (JAK)/STAT6 signaling pathway. Moreover, triggering of CD45 with anti-CD45 Abs can inhibit IL-4-induced AID expression, and this CD45-mediated AID inhibition correlated with the ability of anti-CD45 to suppress IL-4-activated JAK1, JAK3, and STAT6 phosphorylations file:human/JAK1/JAK1-deep-research-falcon.md - **Common Ξ³-chain cytokines** (e.g., **ILβ2, ILβ4, ILβ7, ILβ21**): **JAK1 + JAK3**. |
| GO:0038111 interleukin-7-mediated signaling pathway | IDA PMID:29202461 IL-7-dependent STAT1 activation limits homeostatic CD4+ T ce... | ACCEPT | Summary: Critical cytokine pathway for lymphocyte development Reason: JAK1 is essential for IL-7 signaling, which is crucial for T-cell and B-cell development. Core pathway for JAK1. Supporting Evidence: PMID:29202461 The phosphorylated active form of JAK3 then phosphorylates tyrosine 449 on IL-7RΞ±, generating a docking site for the signal transducers and activators of transcription 5 (STAT5) file:human/JAK1/JAK1-deep-research-falcon.md - **Common Ξ³-chain cytokines** (e.g., **ILβ2, ILβ4, ILβ7, ILβ21**): **JAK1 + JAK3**. |
| GO:0072540 T-helper 17 cell lineage commitment | TAS PMID:27893700 Trans-presentation of IL-6 by dendritic cells is required fo... | KEEP AS NON CORE | Summary: Downstream differentiation process mediated by JAK1 Reason: JAK1 contributes to Th17 differentiation through cytokine signaling, but this is a downstream consequence rather than core function. Supporting Evidence: PMID:27893700 Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T(H)17 cells. |
| GO:0006357 regulation of transcription by RNA polymerase II | IDA PMID:28753426 Methyltransferase SETD2-Mediated Methylation of STAT1 Is Cri... | KEEP AS NON CORE | Summary: Downstream transcriptional effect of JAK1 signaling Reason: JAK1 regulates transcription indirectly through STAT activation, but the core function is tyrosine kinase activity. Supporting Evidence: PMID:28753426 Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity. |
| GO:1900182 positive regulation of protein localization to nucleus | IDA PMID:26479788 PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and v... | KEEP AS NON CORE | Summary: Nuclear translocation regulation through JAK1 signaling Reason: JAK1 promotes STAT nuclear translocation, but this is a consequence of its kinase activity. Supporting Evidence: PMID:26479788 PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. |
| GO:0060337 type I interferon-mediated signaling pathway | IMP PMID:23391734 STAT2 deficiency and susceptibility to viral illness in huma... | ACCEPT | Summary: Core cytokine pathway - JAK1 essential for Type I IFN responses Reason: Type I interferon signaling is absolutely dependent on JAK1. This is a core biological process for JAK1. Supporting Evidence: PMID:23391734 Patient fibroblasts were indeed abnormally permissive for viral replication in vitro, associated with profound failure of type I IFN signaling and absence of STAT2 protein file:human/JAK1/JAK1-deep-research-falcon.md - **Type I interferons (IFN-Ξ±/Ξ²)**: **JAK1 + TYK2**. |
| GO:0035723 interleukin-15-mediated signaling pathway | IDA PMID:7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and... | ACCEPT | Summary: Specific Ξ³c-dependent cytokine pathway mediated by JAK1 Reason: IL-15 signaling through Ξ³c receptor requires JAK1. Core cytokine pathway function. Supporting Evidence: PMID:7568001 IL-2 and IL-15 rapidly induced the tyrosine phosphorylation of STAT3 and STAT5, and DNA-binding complexes containing STAT3 and STAT5 were rapidly activated by these cytokines in T cells file:human/JAK1/JAK1-deep-research-falcon.md - **Common Ξ³-chain cytokines** (e.g., **ILβ2, ILβ4, ILβ7, ILβ21**): **JAK1 + JAK3**. |
| GO:0038110 interleukin-2-mediated signaling pathway | IDA PMID:7568005 Critical role of the interleukin 2 (IL-2) receptor gamma-cha... | ACCEPT | Summary: Core Ξ³c-dependent cytokine pathway requiring JAK1 Reason: IL-2 is a prototypical Ξ³c cytokine requiring JAK1 for signaling. Core function. Supporting Evidence: PMID:7568005 Two Janus family protein tyrosine kinases (PTKs), Jak1 and Jak3, were shown to associate with IL-2R beta c and IL-2R gamma c, respectively, and their PTK activities are increased after IL-2 stimulation file:human/JAK1/JAK1-deep-research-falcon.md - **Common Ξ³-chain cytokines** (e.g., **ILβ2, ILβ4, ILβ7, ILβ21**): **JAK1 + JAK3**. |
| GO:0038154 interleukin-11-mediated signaling pathway | IDA PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor ... | ACCEPT | Summary: gp130-dependent cytokine pathway mediated by JAK1 Reason: IL-11 signals through gp130 receptor and requires JAK1. Core IL-6 family cytokine function. Supporting Evidence: PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway. |
| GO:0140105 interleukin-10-mediated signaling pathway | IDA PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 ... | ACCEPT | Summary: IL-10 cytokine signaling pathway requiring JAK1 Reason: IL-10 signaling requires JAK1 for STAT activation. Core anti-inflammatory cytokine pathway. Supporting Evidence: PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. file:human/JAK1/JAK1-deep-research-falcon.md - **IL-10 family signaling**: **JAK1 + TYK2**. |
| GO:0038113 interleukin-9-mediated signaling pathway | IDA PMID:9535918 Heteromerization of the gammac chain with the interleukin-9 ... | ACCEPT | Summary: Ξ³c-dependent cytokine pathway mediated by JAK1 Reason: IL-9 signals through Ξ³c receptor and requires JAK1. Core cytokine signaling function. Supporting Evidence: PMID:9535918 Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis |
| GO:0006468 protein phosphorylation | IMP PMID:28111307 JAK1 gain-of-function causes an autosomal dominant immune dy... | ACCEPT | Summary: Core catalytic activity of JAK1 as a tyrosine kinase Reason: Protein phosphorylation is the fundamental enzymatic activity of JAK1. Core molecular function. Supporting Evidence: PMID:28111307 JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome. file:human/JAK1/JAK1-deep-research-falcon.md Operationally in cells, JAK1 catalyzes phosphorylation events on: - **cytokine receptor cytoplasmic tails** (creating phosphotyrosine docking sites), and - **STAT proteins** (triggering STAT dimerization and transcriptional activation). |
| GO:0031625 ubiquitin protein ligase binding | IPI PMID:24882218 Unanchored K48-linked polyubiquitin synthesized by the E3-ub... | KEEP AS NON CORE | Summary: Regulatory interaction for JAK1 degradation control Reason: JAK1 binds ubiquitin ligases for regulation, but this is regulatory rather than core function. Supporting Evidence: PMID:24882218 2014 May 29. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKΞ΅ kinase-mediated antiviral response. |
| GO:0034112 positive regulation of homotypic cell-cell adhesion | IMP PMID:21679692 The tight junction protein ZO-2 and Janus kinase 1 mediate i... | KEEP AS NON CORE | Summary: Downstream cellular effect of JAK1 signaling Reason: Cell adhesion regulation is a downstream consequence of JAK1 signaling in specific contexts. Supporting Evidence: PMID:21679692 The tight junction protein ZO-2 and Janus kinase 1 mediate intercellular communications in vascular smooth muscle cells. |
| GO:0019903 protein phosphatase binding | IPI PMID:11909529 The T cell protein tyrosine phosphatase is a negative regula... | KEEP AS NON CORE | Summary: Regulatory interaction for JAK1 activity control Reason: Phosphatase binding regulates JAK1 activity but is not the core function. Supporting Evidence: PMID:11909529 The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. |
| GO:0046677 response to antibiotic | IDA PMID:16280321 The heat shock protein 90-CDC37 chaperone complex is require... | KEEP AS NON CORE | Summary: Context-specific response mediated through JAK1 signaling Reason: Antibiotic response is context-specific and not representative of JAK1's core function. Supporting Evidence: PMID:16280321 2005 Nov 9. The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. |
| GO:0019221 cytokine-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Duplicate annotation - cytokine-mediated signaling Reason: Valid annotation for JAK1's role in cytokine signaling, even though duplicated. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Duplicate annotation - non-membrane spanning kinase Reason: Valid annotation for JAK1's kinase activity, even though duplicated. |
| GO:0035556 intracellular signal transduction | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Accurate but general biological process Reason: While accurate, this is too general. More specific terms like JAK-STAT pathway and cytokine signaling better describe JAK1's core function. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IEA GO_REF:0000117 | ACCEPT | Summary: Duplicate annotation - JAK-STAT pathway Reason: Valid annotation for JAK1's role in JAK-STAT signaling, even though duplicated. |
| GO:0019221 cytokine-mediated signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: Duplicate annotation - cytokine signaling Reason: Valid annotation for JAK1's cytokine signaling role, even though duplicated. |
| GO:0005515 protein binding | IPI PMID:16710296 UBP43 is a novel regulator of interferon signaling independe... | REMOVE | Summary: UBP43 direct binding interaction confirmed by experimental evidence Reason: PMID:16710296 demonstrates that "Ubp43 specifically binds to the IFNAR2 receptor subunit and inhibits the activity of receptor-associated JAK1." While this shows direct binding, generic protein binding annotations are removed per GO curation guidelines in favor of more specific functional terms. Supporting Evidence: PMID:16710296 May 18. UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. |
| GO:0005515 protein binding | IPI PMID:21220115 Structural snapshots of full-length Jak1, a transmembrane gp... | MODIFY | Summary: Structural study showing JAK1 binding to gp130/IL-6 receptor complex Reason: PMID:21220115 provides structural snapshots of full-length JAK1 in complex with gp130/IL-6/IL-6RΞ± cytokine receptor complex. This demonstrates specific receptor binding rather than generic protein binding. The interaction should be captured as cytokine receptor binding, which is more informative than generic protein binding. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:21220115 Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6RΞ± cytokine receptor complex, and the receptor-Jak1 holocomplex file:human/JAK1/JAK1-deep-research.md Through its N-terminal domains, JAK1 is tightly but non-covalently associated with membrane-proximal regions of type I and II cytokine receptors |
| GO:0005515 protein binding | IPI PMID:25065853 Drug resistance via feedback activation of Stat3 in oncogene... | REMOVE | Summary: STAT3 binding in drug resistance context Reason: Drug resistance study showing feedback activation. Not informative for normal JAK1 function. Supporting Evidence: PMID:25065853 2014 Jul 24. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. |
| GO:0005515 protein binding | IPI PMID:26175413 CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibi... | REMOVE | Summary: JAK2 interaction in JAK inhibitor study Reason: JAK inhibitor drug study, not informative for normal JAK1 function. Supporting Evidence: PMID:26175413 CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Large-scale interactome study Reason: General proteome-wide interactome study, uninformative generic protein binding. Supporting Evidence: PMID:28514442 Architecture of the human interactome defines protein communities and disease networks. |
| GO:0005515 protein binding | IPI PMID:32953130 SARS-CoV-2 N protein antagonizes type I interferon signaling... | KEEP AS NON CORE | Summary: STAT1-JAK1 interaction examined in a study of viral interferon antagonism. Reason: The full text reports interference with the STAT1-JAK1 interaction by SARS-CoV-2 N protein (Supplementary Fig. S1d, e). Retain this experimental binding evidence as non-core because the generic protein binding term does not describe JAK1's specific tyrosine kinase function. Viral perturbation of the interaction is not a reason to remove the underlying binding evidence. Supporting Evidence: PMID:32953130 Moreover, our result showed that SARS-CoV-2 N interfered with the interactions of STAT1 with JAK1 and STAT2 with TYK2 |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Dual proteome-scale network study Reason: Large-scale proteome study, uninformative generic protein binding. Supporting Evidence: PMID:33961781 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. |
| GO:0005515 protein binding | IPI PMID:34521819 SARS-CoV-2 N protein antagonizes type I interferon signaling... | KEEP AS NON CORE | Summary: STAT1-JAK1 interaction cited through a deleted duplicate PubMed record. Reason: PMID:34521819 redirects to PMID:32953130, whose cached full text reports the STAT1-JAK1 interaction and its perturbation by SARS-CoV-2 N protein. Retain the source PMID for GOA provenance and assess the canonical paper. The experimental interaction is supported, but generic protein binding is less informative than JAK1's specific tyrosine kinase function and is non-core. Supporting Evidence: PMID:32953130 Moreover, our result showed that SARS-CoV-2 N interfered with the interactions of STAT1 with JAK1 and STAT2 with TYK2 |
| GO:0005515 protein binding | IPI PMID:34950606 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)... | KEEP AS NON CORE | Summary: Independent co-IP evidence for STAT1-JAK1 binding and its inhibition by SARS-CoV-2 spike protein. Reason: Zhang et al. examine membrane and spike proteins in this independent study, whereas Mu et al. (PMID:32953130) examine nucleocapsid protein. Figure 5D-E reports co-IP assays of STAT1-JAK1 binding and its inhibition by spike protein, consistent with the GOA interaction partner STAT1 (UniProtKB:P42224). Retain this experimental evidence as non-core because generic protein binding is less informative than JAK1's specific tyrosine kinase function. An independent paper supporting the same interaction is not a duplicate PubMed record or a reason to remove the annotation. Supporting Evidence: PMID:34950606 Co-IP assays indicated that the S protein inhibited the binding of JAK1 to STAT1 and subsequently suppressed its phosphorylation |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | REMOVE | Summary: Cancer mutation-directed interactions Reason: Mutation-specific interactions in cancer, not representative of normal JAK1 function. Supporting Evidence: PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. |
| GO:0005131 growth hormone receptor binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Specific receptor interaction but not core function Reason: JAK1 does bind growth hormone receptor, but this is one of many receptor interactions. Core function is broader tyrosine kinase activity for multiple cytokine receptors. |
| GO:0019221 cytokine-mediated signaling pathway | TAS Reactome:R-HSA-6785807 | ACCEPT | Summary: Duplicate annotation from Reactome Reason: Valid annotation from Reactome pathway analysis, even though duplicated. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-1112602 | ACCEPT | Summary: Duplicate Reactome annotation - IL6 receptor signaling Reason: Valid annotation from Reactome for JAK1's role in IL-6 signaling. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-1112703 | ACCEPT | Summary: Duplicate Reactome annotation - PTPN11 phosphorylation Reason: Valid annotation from Reactome for JAK1's kinase activity. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-6786095 | ACCEPT | Summary: Duplicate Reactome annotation - STAT3/STAT6 phosphorylation Reason: Valid annotation from Reactome for JAK1's role in STAT phosphorylation. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-6786096 | ACCEPT | Summary: Duplicate Reactome annotation - IL4R phosphorylation Reason: Valid annotation from Reactome for JAK1's role in IL-4 signaling. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:10825200 Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2... | ACCEPT | Summary: IL-2 signaling hierarchy study Reason: Experimental evidence for JAK1's tyrosine kinase activity in IL-2 signaling. Core function. Supporting Evidence: PMID:10825200 Interleukin-2 (IL-2) activates several different families of tyrosine kinases, but precisely how these kinases interact is not completely understood |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:1386289 A protein tyrosine kinase in the interferon alpha/beta signa... | ACCEPT | Summary: Early characterization of JAK1 in interferon signaling Reason: Foundational paper demonstrating JAK1's tyrosine kinase activity in IFN signaling. Core function. Supporting Evidence: PMID:1386289 A protein tyrosine kinase in the interferon alpha/beta signaling pathway |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:9446616 Interferon gamma activation of Raf-1 is Jak1-dependent and p... | ACCEPT | Summary: IFN-gamma activation of Raf-1 via JAK1 Reason: Experimental evidence for JAK1 kinase activity in IFN-gamma signaling. Core function. Supporting Evidence: PMID:9446616 Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-452122 | ACCEPT | Summary: Reactome annotation - IL2RB phosphorylation Reason: Valid annotation from Reactome for JAK1's kinase activity in IL-2 signaling. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-873924 | ACCEPT | Summary: Reactome annotation - IFNGR1 phosphorylation Reason: Valid annotation from Reactome for JAK1's role in IFN-gamma signaling. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | NAS PMID:12574355 Human activation-induced cytidine deaminase is induced by IL... | ACCEPT | Summary: Duplicate JAK-STAT pathway annotation Reason: Valid annotation for JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:12574355 IL-4-dependent AID induction was inhibited by a dominant-negative STAT6, indicating that IL-4 induced AID expression via the Janus kinase (JAK)/STAT6 signaling pathway |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS... | ACCEPT | Summary: JAK-Tyk kinases in IL-6 family signaling Reason: Direct evidence for JAK1 kinase activity in IL-6 family cytokine signaling. Core function. Supporting Evidence: PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS... | ACCEPT | Summary: Duplicate JAK-STAT annotation Reason: Valid annotation for JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS PMID:34813358 IFNAR1 and IFNAR2 play distinct roles in initiating type I i... | ACCEPT | Summary: IFNAR1/IFNAR2 distinct roles study Reason: Valid annotation for JAK1's kinase activity in interferon signaling. Supporting Evidence: PMID:34813358 Ligand binding results in the cross-phosphorylation of TYK2 and JAK1, which then phosphorylate tyrosine residues in the ICDs of the receptor subunits and members of the STAT family of transcription factors |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:7657660 Phosphorylation and activation of the DNA binding activity o... | ACCEPT | Summary: STAT1 phosphorylation by JAK1 Reason: Valid annotation for JAK1's kinase activity. Supporting Evidence: PMID:7657660 Co-expression of Stat1 with Tyk2, Jak1, or Jak2 resulted in the specific tyrosine phosphorylation of Stat1 at Tyr701 |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS PMID:8232552 The protein tyrosine kinase JAK1 complements defects in inte... | ACCEPT | Summary: Core molecular function confirmed by foundational interferon signaling study Reason: PMID:8232552 established that JAK1 is "completely defective in interferon response" when absent and "complementation of this mutant with JAK1 restored the response," demonstrating JAK1's essential tyrosine kinase activity in interferon signaling. Supporting Evidence: PMID:8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:8232552 The protein tyrosine kinase JAK1 complements defects in inte... | ACCEPT | Summary: Duplicate annotation from key interferon paper Reason: Valid annotation from foundational JAK1 paper. Supporting Evidence: PMID:8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction |
| GO:0006357 regulation of transcription by RNA polymerase II | IDA PMID:9020188 Stat2 is a transcriptional activator that requires sequence-... | KEEP AS NON CORE | Summary: STAT2 transcriptional activation Reason: JAK1 regulates transcription indirectly through STAT activation. Downstream effect. Supporting Evidence: PMID:9020188 Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:23139419 Identification of STAT2 serine 287 as a novel regulatory pho... | ACCEPT | Summary: STAT2 Ser287 phosphorylation in IFN signaling Reason: Valid annotation for JAK1's role in interferon signaling. Supporting Evidence: PMID:23139419 Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:28753426 Methyltransferase SETD2-Mediated Methylation of STAT1 Is Cri... | ACCEPT | Summary: SETD2-mediated STAT1 methylation Reason: Valid annotation for JAK1's role in STAT signaling. Supporting Evidence: PMID:28753426 Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:7526154 Direct binding to and tyrosine phosphorylation of the alpha ... | ACCEPT | Summary: TYK2 binding to IFN receptor Reason: Valid annotation for JAK1's role in interferon signaling. Supporting Evidence: PMID:7526154 Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:7657660 Phosphorylation and activation of the DNA binding activity o... | ACCEPT | Summary: Duplicate JAK-STAT annotation Reason: Valid annotation for JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:7657660 Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:7759950 Soluble and membrane-anchored forms of the human IFN-alpha/b... | ACCEPT | Summary: Duplicate JAK-STAT annotation Reason: Valid annotation for JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:7759950 Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:8605876 Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) ... | ACCEPT | Summary: Duplicate JAK-STAT annotation Reason: Valid annotation for JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:8605876 Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | TAS PMID:8232552 The protein tyrosine kinase JAK1 complements defects in inte... | ACCEPT | Summary: Duplicate JAK-STAT annotation Reason: Valid annotation for JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:8232552 The protein tyrosine kinase JAK1 complements defects in inte... | ACCEPT | Summary: Duplicate JAK-STAT annotation Reason: Valid annotation for JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction |
| GO:1900182 positive regulation of protein localization to nucleus | IDA PMID:8605876 Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) ... | KEEP AS NON CORE | Summary: STAT2 nuclear localization Reason: JAK1 promotes STAT nuclear translocation, but this is downstream of kinase activity. Supporting Evidence: PMID:8605876 Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7532278 Role of STAT2 in the alpha interferon signaling pathway. | ACCEPT | Summary: STAT2 in IFN signaling pathway Reason: Direct evidence for JAK1 kinase activity. Core function. Supporting Evidence: PMID:7532278 Role of STAT2 in the alpha interferon signaling pathway |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7973659 Functional activation of Jak1 and Jak3 by selective associat... | ACCEPT | Summary: JAK1 and JAK3 with IL-2 receptor Reason: Direct evidence for JAK1 kinase activity in IL-2 signaling. Core function. Supporting Evidence: PMID:7973659 Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits |
| GO:0030154 cell differentiation | IDA PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor ... | KEEP AS NON CORE | Summary: IL-11-induced MDSC differentiation Reason: JAK1 contributes to cell differentiation through IL-11 signaling, but this is downstream. Supporting Evidence: PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway. |
| GO:0004713 protein tyrosine kinase activity | IC PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 ... | ACCEPT | Summary: IL-10 induced JAK1 phosphorylation Reason: Inferred from IL-10 signaling studies. Core kinase function. Supporting Evidence: PMID:7543512 # IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes... |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is re... | ACCEPT | Summary: IL-9 receptor signaling Reason: Direct evidence for JAK1 kinase activity in IL-9 signaling. Core function. Supporting Evidence: PMID:8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:10702271 Interleukin (IL)-7 induces rapid activation of Pyk2, which i... | ACCEPT | Summary: IL-7 induced Pyk2 activation Reason: Direct evidence for JAK1 kinase activity in IL-7 signaling. Core function. Supporting Evidence: PMID:10702271 Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:15226449 Distinct regions of the interleukin-7 receptor regulate diff... | ACCEPT | Summary: IL-7 receptor and Bcl2 regulation Reason: Direct evidence for JAK1 kinase activity. Core function. Supporting Evidence: PMID:15226449 Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7929391 JAK1 kinase forms complexes with interleukin-4 receptor and ... | ACCEPT | Summary: IL-4 and IL-9 receptor activation Reason: Direct evidence for JAK1 kinase activity in IL-4/IL-9 signaling. Core function. Supporting Evidence: PMID:7929391 JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes |
| GO:0035771 interleukin-4-mediated signaling pathway | IDA PMID:7760829 Cloning of murine Stat6 and human Stat6, Stat proteins that ... | ACCEPT | Summary: Duplicate IL-4 pathway annotation Reason: Valid annotation for JAK1's role in IL-4 signaling. Supporting Evidence: PMID:7760829 Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:31892268 Characterization of JAK1 Pseudokinase Domain in Cytokine Sig... | ACCEPT | Summary: JAK1 pseudokinase domain characterization Reason: Experimental evidence for JAK1 kinase activity and regulation. Core function. Supporting Evidence: PMID:31892268 Characterization of JAK1 Pseudokinase Domain in Cytokine Signaling |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IMP PMID:28111307 JAK1 gain-of-function causes an autosomal dominant immune dy... | ACCEPT | Summary: JAK1 gain-of-function syndrome Reason: Valid annotation demonstrating JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:28111307 JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IMP PMID:32750333 Complex Autoinflammatory Syndrome Unveils Fundamental Princi... | ACCEPT | Summary: Autoinflammatory syndrome study Reason: Valid annotation demonstrating JAK1's role in JAK-STAT signaling. Supporting Evidence: PMID:32750333 Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function |
| GO:0006468 protein phosphorylation | IMP PMID:32750333 Complex Autoinflammatory Syndrome Unveils Fundamental Princi... | ACCEPT | Summary: Duplicate protein phosphorylation annotation Reason: Valid annotation for JAK1's phosphorylation activity. Supporting Evidence: PMID:32750333 Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function |
| GO:0005515 protein binding | IPI PMID:21679692 The tight junction protein ZO-2 and Janus kinase 1 mediate i... | REMOVE | Summary: ZO-2 binding in smooth muscle cells Reason: Context-specific protein interaction, not informative for JAK1 core function. Supporting Evidence: PMID:21679692 The tight junction protein ZO-2 and Janus kinase 1 mediate intercellular communications in vascular smooth muscle cells. |
| GO:0005515 protein binding | IPI PMID:7759950 Soluble and membrane-anchored forms of the human IFN-alpha/b... | MODIFY | Summary: Type I IFN receptor binding - demonstrates receptor-kinase association Reason: PMID:7759950 describes soluble and membrane-anchored forms of the human IFN-Ξ±/Ξ² receptor, establishing the foundation for understanding JAK1's association with IFNAR receptor subunits. This represents specific cytokine receptor binding rather than generic protein binding. The interaction is better captured as cytokine receptor binding, which is more functionally informative. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:7759950 Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor file:human/JAK1/JAK1-deep-research.md JAK1 associates with the IFNAR2 receptor subunit, while TYK2 associates with IFNAR1 |
| GO:0005131 growth hormone receptor binding | ISS PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and T... | KEEP AS NON CORE | Summary: Growth hormone receptor association Reason: JAK1 does bind GH receptor, but this is one of many receptor interactions. Supporting Evidence: PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. |
| GO:0004713 protein tyrosine kinase activity | TAS PMID:1848670 Two novel protein-tyrosine kinases, each with a second phosp... | ACCEPT | Summary: Early JAK1 characterization paper Reason: Foundational paper identifying JAK1 as a tyrosine kinase. Core function. Supporting Evidence: PMID:1848670 Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase |
| GO:0006468 protein phosphorylation | TAS PMID:1848670 Two novel protein-tyrosine kinases, each with a second phosp... | ACCEPT | Summary: Core catalytic activity of JAK1 as a tyrosine kinase Reason: Protein phosphorylation is the fundamental enzymatic activity of JAK1. This foundational paper provides traceable author statement supporting this core function. Supporting Evidence: PMID:1848670 Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. |
| GO:0035556 intracellular signal transduction | TAS PMID:8232552 The protein tyrosine kinase JAK1 complements defects in inte... | KEEP AS NON CORE | Summary: Accurate but general biological process Reason: While accurate, this is too general. More specific terms like JAK-STAT pathway and cytokine signaling better describe JAK1's core function. Supporting Evidence: PMID:8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction |
| GO:0005829 cytosol | IBA GO_REF:0000033 | ACCEPT | Summary: JAK1 is a cytoplasmic non-receptor tyrosine kinase that localizes to the cytosol when not associated with activated cytokine receptors. It translocates and associates with membrane receptors upon cytokine stimulation. Reason: Cytosol localization is essential for JAK1's function as a mobile signaling kinase that can be recruited to activated cytokine receptors and also phosphorylate cytoplasmic STAT transcription factors. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: JAK1 associates with the growth hormone receptor (alongside JAK2 and TYK2) and contributes to GH-induced JAK-STAT signaling, although JAK2 is the principal kinase for GHR. This is a phylogenetically supported (IBA) cytokine-receptor JAK-STAT pathway, one of many specific cytokine responses mediated by JAK1. Reason: GH receptor signaling via JAK-STAT is a legitimate JAK1-associated cytokine pathway but represents one specific (and JAK2-dominated) instance of JAK1's broad cytokine signaling role rather than its core interferon/IL-6/gamma-c functions. Supporting Evidence: PMID:10502458 Immunoprecipitation by an antibody against the GHR (Mab 263) followed by immunoblotting with specific antibodies against Jak proteins showed that Jak1, Jak2 and Tyk2 were associated with the GHR in this tissue. |
| GO:0005768 endosome | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Electronic (ARBA) annotation placing JAK1 in the endosome. JAK1 can remain receptor-associated as cytokine receptor complexes are internalized into endosomes, but its primary and well-established localization is cytosolic and at the cytoplasmic face of the plasma membrane. Reason: Endosomal localization is plausible as receptor complexes are internalized, but it is a peripheral/transient location rather than a core site of JAK1 action. Supported only by electronic inference. Supporting Evidence: file:human/JAK1/JAK1-deep-research.md JAK1 is predominantly an **intracellular cytosolic protein** localized at the **cytoplasmic side of the plasma membrane** |
| GO:0012505 endomembrane system | IEA GO_REF:0000044 | MARK AS OVER ANNOTATED | Summary: Electronic (UniProt keyword) annotation to the broad endomembrane system compartment. This is an overly general localization for a cytosolic kinase that associates with the cytoplasmic face of the plasma membrane. Reason: The endomembrane system term is too broad and not the principal compartment for JAK1, which is best described as cytosolic and as an extrinsic component of the cytoplasmic side of the plasma membrane. Keyword-based electronic inference. Supporting Evidence: file:human/JAK1/JAK1-deep-research.md the primary **cellular components** associated with JAK1 are the **cytosol** (GO:0005829) and **plasma membrane (cytoplasmic side)** |
| GO:0016020 membrane | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Electronic (InterPro) annotation to the broad parent term membrane. JAK1 is not an integral membrane protein but associates peripherally with the cytoplasmic face of cytokine receptors at the plasma membrane. Reason: Membrane is an overly broad localization; JAK1 is a cytosolic kinase that associates with the cytoplasmic side of the plasma membrane via receptor binding. More specific terms (cytosol, extrinsic component of cytoplasmic side of plasma membrane) are preferred. Supporting Evidence: file:human/JAK1/JAK1-deep-research.md JAK1 is tightly but non-covalently associated with membrane-proximal regions of type I and II cytokine receptors, effectively making it an **extrinsic component of the cytoplasmic face of the plasma membrane** |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IEA GO_REF:0000117 | ACCEPT | Summary: JAK1 associates non-covalently with the cytoplasmic, membrane-proximal box1/box2 motifs of cytokine receptors, positioning it as an extrinsic component of the cytoplasmic side of the plasma membrane. This electronic annotation matches well-established experimental localization. Reason: This is an accurate and appropriately specific cellular component for JAK1, consistent with its receptor-tethered location, even though the supporting evidence here is electronic (it is corroborated by multiple IC/IDA annotations elsewhere in this record). Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs; this receptor tethering is mediated by the **FERM** region (and associated SH2-like elements) |
| GO:0051239 regulation of multicellular organismal process | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: Very general electronic (ARBA) process annotation. While JAK1-mediated cytokine signaling does influence many organismal processes (immune development, inflammation), this term is too high-level to be informative. Reason: This grouping term is far too general to convey JAK1's specific role; its cytokine/JAK-STAT signaling functions are captured by more specific terms. Electronic inference only. |
| GO:0098761 cellular response to interleukin-7 | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: JAK1 is required for IL-7 receptor signaling (paired with JAK3 at the IL-7Ralpha/common gamma-chain receptor), so cellular response to IL-7 is a legitimate process. This is one of many specific cytokine responses mediated by JAK1. Reason: Accurate but represents one specific gamma-c cytokine response rather than JAK1's core kinase/cytokine-signaling function; the dedicated IL-7-mediated signaling pathway annotation is more informative. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md - **Common Ξ³-chain cytokines** (e.g., **ILβ2, ILβ4, ILβ7, ILβ21**): **JAK1 + JAK3**. |
| GO:0060333 type II interferon-mediated signaling pathway | NAS PMID:15864272 Mechanisms of type-I- and type-II-interferon-mediated signal... | ACCEPT | Summary: Core cytokine pathway - JAK1 essential for IFN-gamma signaling via JAK1/JAK2 pairing Reason: Type II interferon (IFN-gamma) signaling requires JAK1 paired with JAK2. Core biological process for JAK1. Supporting Evidence: PMID:15864272 Mechanisms of type-I- and type-II-interferon-mediated signalling. file:human/JAK1/JAK1-deep-research-falcon.md - **IFN-Ξ³ receptor signaling**: **JAK1 + JAK2** leading to STAT1 recruitment/activation (representative example in immunology/cancer context). |
| GO:0098586 cellular response to virus | NAS PMID:15864272 Mechanisms of type-I- and type-II-interferon-mediated signal... | KEEP AS NON CORE | Summary: JAK1 contributes to antiviral defense as part of the interferon signaling machinery, but cellular response to virus is a downstream physiological outcome rather than JAK1's direct molecular role. Reason: This is a downstream/peripheral process; JAK1's antiviral relevance is mediated through its core type I/II/III interferon signaling functions, which are annotated separately and more specifically. Supporting Evidence: PMID:15864272 Mechanisms of type-I- and type-II-interferon-mediated signalling. |
| GO:0038110 interleukin-2-mediated signaling pathway | TAS Reactome:R-HSA-9020558 | ACCEPT | Summary: IL-2 signals through the IL-2 receptor complex where JAK1 (associated with IL2RB) partners with JAK3 (associated with the common gamma chain) to phosphorylate the receptor and STAT5. Core gamma-c cytokine pathway for JAK1. Reason: IL-2 is a prototypical common gamma-chain cytokine that strictly requires JAK1; this Reactome TAS pathway annotation is well-supported and reflects a core JAK1 function. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md - **Common Ξ³-chain cytokines** (e.g., **ILβ2, ILβ4, ILβ7, ILβ21**): **JAK1 + JAK3**. |
| GO:0060333 type II interferon-mediated signaling pathway | TAS Reactome:R-HSA-877300 | ACCEPT | Summary: Type II interferon (IFN-gamma) signaling requires JAK1 paired with JAK2 at the IFNGR complex to phosphorylate STAT1. Core cytokine pathway for JAK1 (Reactome Interferon gamma signaling). Reason: IFN-gamma signaling is strictly JAK1-dependent; well-supported core pathway. Duplicates the NAS/IDA type II IFN annotations, which is acceptable. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md - **IFN-Ξ³ receptor signaling**: **JAK1 + JAK2** leading to STAT1 recruitment/activation (representative example in immunology/cancer context). |
| GO:0060337 type I interferon-mediated signaling pathway | TAS Reactome:R-HSA-909733 | ACCEPT | Summary: Type I interferon (IFN-alpha/beta) signaling requires JAK1 (at IFNAR2) paired with TYK2 (at IFNAR1) to cross-phosphorylate and activate STAT1/STAT2. Core cytokine pathway for JAK1 (Reactome Interferon alpha/beta signaling). Reason: Type I IFN signaling is strictly JAK1-dependent; well-supported core pathway. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md - **Type I interferons (IFN-Ξ±/Ξ²)**: **JAK1 + TYK2**. |
| GO:0070102 interleukin-6-mediated signaling pathway | TAS Reactome:R-HSA-1059683 | ACCEPT | Summary: Core IL-6 family cytokine pathway mediated by JAK1 via gp130 receptor Reason: IL-6 family cytokines signal through the gp130/IL6ST receptor, where JAK1 is the principal JAK kinase. Core cytokine pathway for JAK1. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md - **ILβ6/gp130 signaling**: JAK1 is described as associating with the **gp130** receptor system (a major pro-inflammatory axis). |
| GO:0038196 type III interferon-mediated signaling pathway | NAS PMID:30936491 Decoding type I and III interferon signalling during viral i... | ACCEPT | Summary: Type III interferons (IFN-lambda) signal through the IFNLR1/IL10RB receptor, where JAK1 (at IFNLR1) pairs with TYK2 (at IL10RB) to activate STAT1/STAT2. JAK1 is essential for IFN-lambda antiviral signaling. Reason: Type III IFN signaling is JAK1-dependent (JAK1 binds IFNLR1), a core cytokine pathway for JAK1, supported by the cited review and corroborated by Reactome IFN-lambda reactions in this record. Supporting Evidence: PMID:30936491 2019 Apr 1. Decoding type I and III interferon signalling during viral infection. |
| GO:0043235 receptor complex | IPI PMID:21854986 Structural linkage between ligand discrimination and recepto... | ACCEPT | Summary: JAK1 is a constitutive component of cytokine receptor complexes, binding the cytoplasmic tails of receptor subunits (e.g., IFNAR2) as part of the assembled signaling complex. Membership in the receptor complex is integral to JAK1's function. Reason: JAK1 is a bona fide part of cytokine receptor signaling complexes; this is a core structural/localization aspect of its function, supported by structural and biochemical studies of interferon and other cytokine receptors. Supporting Evidence: file:human/JAK1/JAK1-deep-research.md Through its N-terminal domains, JAK1 is tightly but non-covalently associated with membrane-proximal regions of type I and II cytokine receptors |
| GO:0060337 type I interferon-mediated signaling pathway | NAS PMID:30936491 Decoding type I and III interferon signalling during viral i... | ACCEPT | Summary: Type I interferon (IFN-alpha/beta) signaling requires JAK1 (at IFNAR2) together with TYK2 to activate STAT1/STAT2. Core antiviral cytokine pathway for JAK1. Reason: Core JAK1 pathway; well supported. Duplicates other type I IFN annotations in this record, which is acceptable. Supporting Evidence: PMID:30936491 2019 Apr 1. Decoding type I and III interferon signalling during viral infection. |
| GO:0098586 cellular response to virus | NAS PMID:30936491 Decoding type I and III interferon signalling during viral i... | KEEP AS NON CORE | Summary: JAK1 participates in antiviral defense through type I/III interferon signaling, but cellular response to virus is a downstream physiological outcome rather than JAK1's direct molecular function. Reason: Downstream/peripheral process mediated via JAK1's core interferon signaling functions, which are annotated more specifically. Duplicate of the PMID:15864272 cellular response to virus annotation. Supporting Evidence: PMID:30936491 2019 Apr 1. Decoding type I and III interferon signalling during viral infection. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8986994 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987080 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987097 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987129 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987150 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987230 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987255 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987270 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005886 plasma membrane | TAS PMID:34813358 IFNAR1 and IFNAR2 play distinct roles in initiating type I i... | ACCEPT | Summary: Upon cytokine stimulation JAK1 is active at the plasma membrane, where it is recruited to and cross-phosphorylates the cytoplasmic tails of receptor subunits (e.g., IFNAR2) and STAT factors. is_active_in plasma membrane reflects the membrane-proximal site of JAK1 catalysis. Reason: The site of JAK1 catalytic action is the cytoplasmic face of cytokine receptors at the plasma membrane; this is consistent with the more specific extrinsic-component/cytoplasmic-side annotations and is appropriate. Supporting Evidence: PMID:34813358 Ligand binding results in the cross-phosphorylation of TYK2 and JAK1, which then phosphorylate tyrosine residues in the ICDs of the receptor subunits and members of the STAT family of transcription factors |
| GO:0060333 type II interferon-mediated signaling pathway | IDA PMID:8232552 The protein tyrosine kinase JAK1 complements defects in inte... | ACCEPT | Summary: JAK1-deficient cells are unresponsive to IFN-gamma, and JAK1 complementation restores signaling, demonstrating JAK1 is essential for type II interferon (IFN-gamma) signaling (with JAK2). Core JAK1 cytokine pathway. Reason: Direct experimental (complementation) evidence that JAK1 is required for IFN-gamma signaling. Core function. Supporting Evidence: PMID:8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. |
| GO:0060337 type I interferon-mediated signaling pathway | IDA PMID:8232552 The protein tyrosine kinase JAK1 complements defects in inte... | ACCEPT | Summary: JAK1-deficient cells fail to respond to IFN-alpha/beta and JAK1 complementation restores signaling, demonstrating JAK1 is essential for type I interferon signaling (with TYK2). Core JAK1 cytokine pathway. Reason: Direct experimental (complementation) evidence that JAK1 is required for type I IFN signaling. Core function. Supporting Evidence: PMID:8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. |
| GO:0005737 cytoplasm | IC PMID:7532278 Role of STAT2 in the alpha interferon signaling pathway. | ACCEPT | Summary: JAK1 is a cytoplasmic kinase that, in the alpha interferon pathway, acts in the cytoplasm to phosphorylate receptor subunits and STAT factors. is_active_in cytoplasm is consistent with JAK1's well-established cytoplasmic/cytosolic localization. Reason: Accurate cellular component for JAK1's site of action, inferred from its role in cytoplasmic interferon signaling. The more specific cytosol and cytoplasmic-side-of-plasma-membrane terms are also annotated. Supporting Evidence: file:human/JAK1/JAK1-deep-research.md JAK1 is predominantly an **intracellular cytosolic protein** localized at the **cytoplasmic side of the plasma membrane** |
| GO:0060337 type I interferon-mediated signaling pathway | IDA PMID:7532278 Role of STAT2 in the alpha interferon signaling pathway. | ACCEPT | Summary: JAK1 is required for alpha-interferon (type I IFN) signaling and STAT2 activation. Core JAK1 cytokine pathway. Reason: Direct evidence for JAK1's role in type I IFN/STAT2 signaling. Core function; duplicates other type I IFN annotations, which is acceptable. Supporting Evidence: PMID:7532278 Role of STAT2 in the alpha interferon signaling pathway. |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IDA PMID:7973659 Functional activation of Jak1 and Jak3 by selective associat... | ACCEPT | Summary: JAK1 associates with the cytoplasmic domains of activated cytokine receptors at the plasma membrane, where it becomes phosphorylated and activated to propagate downstream signaling cascades. Reason: JAK1's association with the cytoplasmic side of plasma membrane-bound receptors is crucial for cytokine signal transduction, allowing it to be activated by receptor engagement and to phosphorylate other signaling proteins in close proximity to the membrane. Supporting Evidence: PMID:7973659 Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs; this receptor tethering is mediated by the **FERM** region (and associated SH2-like elements) and positions JAK1 for rapid activation upon receptor engagement/dimerization. |
| GO:0038154 interleukin-11-mediated signaling pathway | IDA PMID:8272872 Association of transcription factor APRF and protein kinase ... | ACCEPT | Summary: IL-11 is an IL-6-family cytokine that signals through the gp130 (IL6ST) receptor, where JAK1 is the principal JAK. JAK1 associates with gp130 to mediate IL-11 signaling. Reason: IL-11 signals through gp130 and requires JAK1; this is a legitimate IL-6-family cytokine pathway for JAK1. Accepted consistently with the other accepted specific cytokine pathway annotations. The cited reference concerns gp130 (IL-6 transducer) and JAK1 association. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md - **ILβ6/gp130 signaling**: JAK1 is described as associating with the **gp130** receptor system (a major pro-inflammatory axis). |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IC PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS... | ACCEPT | Summary: JAK1 associates with and is activated at the cytoplasmic tails of gp130-family receptor components (CNTF/LIF/OSM/IL-6 beta receptor), consistent with its location as an extrinsic component of the cytoplasmic side of the plasma membrane. Reason: Accurate, appropriately specific localization for receptor-associated JAK1, inferred from its activation by membrane-anchored receptor subunits. Supporting Evidence: PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IC PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 ... | ACCEPT | Summary: IL-10 induces tyrosine phosphorylation of JAK1 (and TYK2) at the IL-10 receptor, consistent with JAK1 acting as an extrinsic component of the cytoplasmic side of the plasma membrane when receptor-associated. Reason: Accurate, appropriately specific localization for receptor-associated JAK1, inferred from its IL-10 receptor-driven activation. Supporting Evidence: PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IC PMID:8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is re... | ACCEPT | Summary: JAK1 acts at the IL-9 receptor to mediate STAT activation, consistent with its location as an extrinsic component of the cytoplasmic side of the plasma membrane when associated with the receptor. Reason: Accurate, appropriately specific localization for receptor-associated JAK1, inferred from its role in IL-9 receptor signaling. Supporting Evidence: PMID:8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. |
| GO:0038113 interleukin-9-mediated signaling pathway | IDA PMID:8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is re... | ACCEPT | Summary: IL-9 signals via the IL-9 receptor (with common gamma chain), where JAK1 (paired with JAK3) is required for STAT activation, anti-apoptotic activity, and growth regulation. Reason: JAK1 is required for IL-9 receptor STAT activation, a gamma-c cytokine pathway. Accepted consistently with the other accepted specific gamma-c cytokine pathway annotations (IL-2, IL-4, IL-7). Supporting Evidence: PMID:8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. |
| GO:0038110 interleukin-2-mediated signaling pathway | IDA PMID:7973659 Functional activation of Jak1 and Jak3 by selective associat... | ACCEPT | Summary: JAK1 (associated with IL-2Rbeta) is functionally activated by IL-2 receptor engagement, together with JAK3 on the common gamma chain. Core gamma-c cytokine pathway for JAK1. Reason: Direct experimental evidence that JAK1 is selectively associated with and activated by IL-2 receptor subunits. Core function; duplicates the Reactome IL-2 pathway annotation. Supporting Evidence: PMID:7973659 Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. |
| GO:0005886 plasma membrane | IC PMID:10702271 Interleukin (IL)-7 induces rapid activation of Pyk2, which i... | ACCEPT | Summary: JAK1 is bound to IL-7Ralpha at the plasma membrane and is active there during IL-7 signaling (e.g., in a complex with Pyk2). is_active_in plasma membrane reflects the membrane-proximal site of JAK1 catalysis. Reason: Consistent with JAK1's receptor-associated, membrane-proximal site of action. Accurate localization, corroborated by the more specific cytoplasmic-side-of-plasma-membrane annotations. Supporting Evidence: PMID:10702271 Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha. |
| GO:0009898 cytoplasmic side of plasma membrane | IC PMID:20974963 Thymic stromal lymphopoietin-mediated STAT5 phosphorylation ... | ACCEPT | Summary: JAK1 (with JAK2) acts at the cytoplasmic side of the plasma membrane in TSLP-mediated STAT5 phosphorylation, consistent with its receptor-associated, membrane-proximal site of catalysis. Reason: Accurate, appropriately specific cellular component for JAK1's site of action, inferred from its membrane-proximal receptor signaling. Supporting Evidence: PMID:20974963 Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IC PMID:7973659 Functional activation of Jak1 and Jak3 by selective associat... | ACCEPT | Summary: JAK1 selectively associates with the IL-2 receptor beta subunit, acting as an extrinsic component of the cytoplasmic side of the plasma membrane when receptor-bound. Reason: Accurate, appropriately specific localization for receptor-associated JAK1, inferred from its IL-2 receptor association/activation. Supporting Evidence: PMID:7973659 Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. |
| GO:0038111 interleukin-7-mediated signaling pathway | IC PMID:20974963 Thymic stromal lymphopoietin-mediated STAT5 phosphorylation ... | ACCEPT | Summary: JAK1 is required for IL-7 receptor signaling (IL-7Ralpha/common gamma chain, with JAK3), driving STAT5 activation. This study contrasts IL-7 with TSLP signaling. Core gamma-c cytokine pathway for JAK1. Reason: JAK1 is essential for IL-7 signaling, a core gamma-c cytokine pathway important for lymphocyte development. Inferred from the comparison of IL-7 vs TSLP signaling. Supporting Evidence: PMID:20974963 Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IC PMID:7929391 JAK1 kinase forms complexes with interleukin-4 receptor and ... | ACCEPT | Summary: JAK1 forms complexes with the IL-4 receptor and is activated by IL-4/IL-9, acting as an extrinsic component of the cytoplasmic side of the plasma membrane when receptor-associated. Reason: Accurate, appropriately specific localization for receptor-associated JAK1, inferred from its IL-4/IL-9 receptor complex formation. Supporting Evidence: PMID:7929391 JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes. |
| GO:0035771 interleukin-4-mediated signaling pathway | IDA PMID:7929391 JAK1 kinase forms complexes with interleukin-4 receptor and ... | ACCEPT | Summary: JAK1 forms complexes with the IL-4 receptor and is activated by IL-4, mediating IL-4 signaling (with JAK3 on the common gamma chain). Core gamma-c cytokine pathway for JAK1. Reason: Direct evidence that JAK1 forms a complex with and is activated by the IL-4 receptor. Core gamma-c cytokine signaling function; duplicates other IL-4 pathway annotations. Supporting Evidence: PMID:7929391 JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes. |
| GO:0009898 cytoplasmic side of plasma membrane | IDA PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS... | ACCEPT | Summary: JAK1 associates with and is activated at the cytoplasmic side of gp130-family (CNTF/LIF/OSM/IL-6 beta) receptor components, consistent with its membrane-proximal site of action. Reason: Accurate, appropriately specific cellular component for receptor-associated JAK1, inferred/observed from its activation by membrane-anchored receptor subunits. Supporting Evidence: PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS... | ACCEPT | Summary: JAK1 associates with and is activated by gp130 (IL-6 beta receptor) and related IL-6-family receptor components (CNTF/LIF/OSM), making it the principal JAK for IL-6-family cytokine signaling. Core JAK1 cytokine pathway. Reason: JAK1 is the dominant JAK for gp130/IL-6-family signaling; direct evidence of association and activation. Core function; duplicates the Reactome IL-6 annotation. Supporting Evidence: PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. |
| GO:0150105 protein localization to cell-cell junction | IMP PMID:21679692 The tight junction protein ZO-2 and Janus kinase 1 mediate i... | KEEP AS NON CORE | Summary: In vascular smooth muscle cells, active JAK1 mediates phosphorylation of the tight-junction protein ZO-2 and its localization to sites of intercellular contact, a specialized non-canonical role distinct from JAK1's cytokine signaling functions. Reason: Supported by a single cell-type-specific study (active JAK1 required for ZO-2 localization to intercellular contacts). This is a peripheral, context-specific function rather than JAK1's core cytokine/JAK-STAT role. Supporting Evidence: PMID:21679692 active Jak1, but not Jak1 inactive mutant, mediates ZO-2 localization to the sites of intercellular contacts |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950340 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950405 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950441 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950453 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950485 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950518 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950537 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8982162 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8982163 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8982165 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983300 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983834 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983835 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983841 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983845 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983983 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983996 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984012 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984014 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984021 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984023 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8986985 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8986995 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987012 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987014 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987033 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987040 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987042 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987063 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987070 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987084 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987096 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987132 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987161 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987202 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987236 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987266 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9009227 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1067651 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1067659 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1067688 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112514 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1169406 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1295540 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1678841 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448427 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448480 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448660 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448661 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448708 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448728 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448744 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-449115 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-449803 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-449811 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-449958 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-449976 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-449978 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-450027 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-450063 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-451900 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-451942 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5696482 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783524 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783530 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783552 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783556 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783681 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784189 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784204 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784319 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6785165 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786050 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786058 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786096 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786110 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788571 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788582 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788628 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6809140 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873918 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873919 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873926 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-877269 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854645 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950210 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950448 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950757 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8952807 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8963734 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983003 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983063 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983298 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983335 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983518 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984001 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985900 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985914 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985929 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985973 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985988 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8986446 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8986480 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8986972 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987015 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987039 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987043 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987104 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987105 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987120 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987141 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987156 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987179 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987220 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9005980 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9006844 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9006850 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9011748 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9025969 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909720 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909724 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909729 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9677579 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9677585 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9678561 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9678935 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9696179 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-997314 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005768 endosome | TAS Reactome:R-HSA-8983335 | KEEP AS NON CORE | Summary: This Reactome reaction describes the IL-15 receptor complex (including JAK1) translocating from the plasma membrane to the endosome, so JAK1 transiently localizes to the endosome as part of internalized receptor complexes. Reason: Endosomal localization is a transient, receptor-internalization-associated location rather than JAK1's core site of action (cytosol/cytoplasmic side of plasma membrane). Supported by a specific Reactome receptor-trafficking reaction. Supporting Evidence: Reactome:R-HSA-8983335 IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome |
| GO:1903672 positive regulation of sprouting angiogenesis | IGI PMID:20299512 Members of the microRNA-17-92 cluster exhibit a cell-intrins... | MARK AS OVER ANNOTATED | Summary: This study identified JAK1 as a direct target of the antiangiogenic miR-17, inferring a proangiogenic contribution of JAK1 in endothelial cells. The evidence is indirect (JAK1 inferred via miRNA targeting) rather than a demonstrated direct role of JAK1 in sprouting angiogenesis. Reason: The annotation rests on JAK1 being a miR-17 target in an antiangiogenic miRNA study, not on direct evidence that JAK1 positively regulates sprouting angiogenesis. This is a weak, indirect over-annotation peripheral to JAK1's core cytokine signaling role. Supporting Evidence: PMID:20299512 Janus kinase 1 was shown to be a direct target of miR-17 |
| GO:0005925 focal adhesion | HDA PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome... | KEEP AS NON CORE | Summary: JAK1 was detected in a high-throughput proteomic survey of the myosin-II-responsive focal adhesion proteome. This places JAK1 in a focal-adhesion-associated fraction but does not establish a functional role there. Reason: Based solely on detection in a large-scale focal adhesion proteomics dataset (HDA). Plausible but peripheral and not a core localization for JAK1, whose established sites are the cytosol and cytoplasmic side of the plasma membrane. Supporting Evidence: PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ξ²-Pix in negative regulation of focal adhesion maturation. |
| GO:0038110 interleukin-2-mediated signaling pathway | IDA PMID:11909529 The T cell protein tyrosine phosphatase is a negative regula... | ACCEPT | Summary: JAK1 (with JAK3) drives IL-2 receptor signaling and is negatively regulated by the T-cell protein tyrosine phosphatase (TC-PTP), confirming JAK1's role in the IL-2-mediated pathway. Core gamma-c cytokine pathway for JAK1. Reason: Supports JAK1's participation in IL-2 signaling (as a substrate/effector regulated by TC-PTP). Core function; duplicates other IL-2 pathway annotations, which is acceptable. Supporting Evidence: PMID:11909529 The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112510 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112565 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112602 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112604 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112690 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112703 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112708 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112727 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112755 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-452091 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-452097 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-452100 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-452108 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-452122 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453104 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453111 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-508247 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-508282 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-508292 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784006 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784323 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784324 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784791 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786072 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786095 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786124 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873921 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873922 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873924 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873927 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983371 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983374 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983378 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983384 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9006870 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9006873 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909552 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909718 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909719 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909722 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909726 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909730 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909732 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-912527 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913374 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913424 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-919404 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9674816 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9705738 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9707977 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9732729 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9732738 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9732753 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-997309 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005829 cytosol | TAS Reactome:R-HSA-997311 | ACCEPT | Summary: JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase. Reason: Cytosol is a well-supported subcellular location for JAK1, consistent with its function as a soluble cytoplasmic kinase that associates with membrane-proximal receptor motifs. Group-accepted across the redundant Reactome reaction-level annotations. Supporting Evidence: file:human/JAK1/JAK1-deep-research-falcon.md JAKs are cytosolic kinases that are **anchored near the plasma membrane** by binding to cytokine receptor cytoplasmic motifs |
| GO:0005634 nucleus | IDA PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and T... | REMOVE | Summary: The cited reference (GHR associates with JAK1/JAK2/TYK2 in human liver) demonstrates cytoplasmic/membrane GHR-JAK1 association and provides no evidence for nuclear JAK1. Although some studies report context-dependent nuclear JAK1, this PMID does not support a nucleus localization. Reason: The original reference does not support nuclear localization of JAK1; it shows GHR-associated (membrane/cytoplasmic) JAK1 in liver. Any nuclear role is weakly and inconsistently supported elsewhere and is not JAK1's established localization. Supporting Evidence: PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. |
| GO:0005737 cytoplasm | IDA PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and T... | ACCEPT | Summary: JAK1 is detected associated with the growth hormone receptor in human liver, consistent with its cytoplasmic localization as a receptor-associated non-receptor tyrosine kinase. Reason: Cytoplasm is a well-established and accurate localization for JAK1; the cited study supports cytoplasmic/membrane GHR-JAK1 association. The more specific cytosol term is also annotated. Supporting Evidence: PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. |
| GO:0038114 interleukin-21-mediated signaling pathway | TAS Reactome:R-HSA-9006844 | NEW | Summary: IL-21 signals through the IL-21 receptor (IL21R) together with the common gamma chain, where JAK1 (bound to IL21R) pairs with JAK3 to phosphorylate the receptor and STAT factors. JAK1 is the receptor-proximal kinase for IL-21, a gamma-c cytokine. This annotation is not otherwise present in the GOA set but is well-supported by Reactome IL-21 receptor reactions. Reason: JAK1 binds IL21R and mediates IL-21 receptor JAK/STAT signaling (a gamma-c cytokine pathway), but no IL-21-mediated signaling pathway annotation existed in the reviewed set. Added based on Reactome IL-21 receptor assembly/phosphorylation reactions and JAK1's established gamma-c cytokine role. Supporting Evidence: Reactome:R-HSA-9006844 IL21:IL21R:JAK1 binds IL2RG:JAK3 file:human/JAK1/JAK1-deep-research-falcon.md - **Common Ξ³-chain cytokines** (e.g., **ILβ2, ILβ4, ILβ7, ILβ21**): **JAK1 + JAK3**. |
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Download this section (compressed HTML)Q: How does JAK1 achieve specificity in cytokine signaling despite being used by multiple different cytokine receptors?
Q: What are the molecular mechanisms of JAK1 activation and how do negative regulatory mechanisms prevent inappropriate signaling?
Q: How do JAK1 inhibitors achieve selectivity and what are the structural determinants of drug binding and specificity?
Q: What role does JAK1 play in immune cell development versus mature immune cell function and how is this regulated?
Experiment: Cryo-EM structures of JAK1 in complex with different cytokine receptors to understand receptor-specific activation mechanisms
Experiment: Single-cell RNA sequencing of immune cells with JAK1 perturbations to map cell-type-specific transcriptional responses
Experiment: Chemical proteomics to identify off-target effects and selectivity profiles of JAK1 inhibitors in development
Experiment: Real-time measurement of JAK1 kinase activity using FRET-based biosensors in response to different cytokines
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Download this section (compressed HTML)π View Pathway Visualization Interactive pathway diagram with detailed annotations