JAK2 is a Janus-family non-receptor tyrosine kinase composed of an N-terminal FERM and SH2-like region that binds the membrane-proximal box1/box2 motifs of cytokine receptors, a regulatory pseudokinase (JH2) domain, and a C-terminal tyrosine kinase (JH1) domain. It associates constitutively with the cytoplasmic tails of many class I and II cytokine receptors, including those for erythropoietin, thrombopoietin, growth hormone, prolactin, leptin, GM-CSF/IL-3/IL-5 (beta c), gp130-family cytokines, IL-12/IL-23 and interferon gamma. Ligand-induced receptor rearrangement brings JAK2 molecules together, allowing trans-autophosphorylation of the activation loop (Tyr1007), after which JAK2 phosphorylates receptor tyrosines that recruit STAT proteins and then phosphorylates the STATs, which dimerize and enter the nucleus to regulate transcription. JAK2 is a cytoplasmic protein acting at the inner face of the plasma membrane; a nuclear pool has been reported to phosphorylate histone H3 Tyr41. JAK2 is essential for definitive erythropoiesis, and gain-of-function mutations such as V617F in the pseudokinase domain drive myeloproliferative neoplasms.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000785 chromatin | IDA PMID:19783980 JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from... | KEEP AS NON CORE | Summary: A nuclear/chromatin pool of JAK2 has been reported. Reason: Nuclear JAK2 phosphorylating H3Y41 is reported in haematopoietic cells; this is a secondary location relative to the receptor-associated cytoplasmic pool. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0000791 euchromatin | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: A nuclear/chromatin pool of JAK2 has been reported. Reason: Nuclear JAK2 phosphorylating H3Y41 is reported in haematopoietic cells; this is a secondary location relative to the receptor-associated cytoplasmic pool. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0001774 microglial cell activation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0001774 microglial cell activation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0002376 immune system process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | MODIFY | Summary: Generic protein kinase activity. Reason: Correct but too general; JAK2 is a tyrosine kinase that does not span the membrane, captured by non-membrane spanning protein tyrosine kinase activity, which the gene already carries. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity |
| GO:0004672 protein kinase activity | NAS PMID:9670957 The chemokine monocyte chemotactic protein 1 triggers Janus ... | MODIFY | Summary: Generic protein kinase activity. Reason: Correct but too general; JAK2 is a tyrosine kinase that does not span the membrane, captured by non-membrane spanning protein tyrosine kinase activity, which the gene already carries. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:15143187 Autophosphorylation of JAK2 on tyrosines 221 and 570 regulat... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:16174768 The structural basis of Janus kinase 2 inhibition by a poten... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:19665053 Gab1 transduces PI3K-mediated erythropoietin signals to the ... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:20304997 Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:9111318 Activation of Jak2 catalytic activity requires phosphorylati... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:12023369 A receptor for the heterodimeric cytokine IL-23 is composed ... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:15690087 SOCS2 negatively regulates growth hormone action in vitro an... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:20974963 Thymic stromal lymphopoietin-mediated STAT5 phosphorylation ... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:23061660 Discovery of potent and selective pyrazolopyrimidine janus k... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:8007942 JAK2 associates with the beta c chain of the receptor for gr... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:9618263 Cloning and characterization of human Jak-2 kinase: high mRN... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS PMID:9670957 The chemokine monocyte chemotactic protein 1 triggers Janus ... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-3215391 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-873918 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-873919 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-873922 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-879907 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-8983872 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9670418 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9958871 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:15690087 SOCS2 negatively regulates growth hormone action in vitro an... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:9657743 Erythropoietin induces tyrosine phosphorylation of Jak2, STA... | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-1112602 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-1112703 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-6788582 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-879910 | ACCEPT | Summary: JAK2 is a non-receptor protein tyrosine kinase that autophosphorylates and phosphorylates cytokine receptors and STATs. Reason: Core catalytic activity. Activation-loop Tyr1007 mutation abolishes kinase activity, a kinase-dead mutant is not phosphorylated during receptor aggregation, and cytokines such as EPO induce JAK2-dependent STAT5 phosphorylation in primary human cells. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9111318 phosphorylation of a kinase-inactive mutant (K882E) was not detected, indicating that Jak2 activation during receptor aggregation is dependent on Jak2 and not another receptor-associated kinase PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0005102 signaling receptor binding | IEA GO_REF:0000117 | MODIFY | Summary: JAK2 binds the cytoplasmic box1/box2 region of cytokine and hormone receptors. Reason: Correct but general. The receptors JAK2 binds are cytokine-family receptors (including GHR, EPOR, MPL, beta c, gp130, IL-23R); cytokine receptor binding is the appropriately specific term. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0005102 signaling receptor binding | IPI PMID:11201744 CD45 is a JAK phosphatase and negatively regulates cytokine ... | MODIFY | Summary: Interaction with the transmembrane phosphatase CD45 (PTPRC), which dephosphorylates JAKs. Reason: The study shows the transmembrane phosphatase CD45 binding and dephosphorylating JAKs. JAK2 is the substrate rather than a ligand of a signaling receptor, so the binding is better described as phosphatase binding. Proposed replacements: phosphatase binding Supporting Evidence: PMID:11201744 Here we show that CD45 suppresses JAK (Janus kinase) kinases and negatively regulates cytokine receptor signalling. |
| GO:0005131 growth hormone receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: JAK2 binds the cytoplasmic domain of a specific cytokine-family receptor. Reason: JAK2 constitutively associates via its FERM domain with membrane-proximal box1/box2 of the growth hormone receptor and IL-12 receptor beta 2, among others; this receptor binding is central to its role. Supporting Evidence: PMID:10502458 We conclude that the GHR associates with Jak1, Jak2 and Tyk2 in human liver. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0005131 growth hormone receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: JAK2 binds the cytoplasmic domain of a specific cytokine-family receptor. Reason: JAK2 constitutively associates via its FERM domain with membrane-proximal box1/box2 of the growth hormone receptor and IL-12 receptor beta 2, among others; this receptor binding is central to its role. Supporting Evidence: PMID:10502458 We conclude that the GHR associates with Jak1, Jak2 and Tyk2 in human liver. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0005131 growth hormone receptor binding | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 binds the cytoplasmic domain of a specific cytokine-family receptor. Reason: JAK2 constitutively associates via its FERM domain with membrane-proximal box1/box2 of the growth hormone receptor and IL-12 receptor beta 2, among others; this receptor binding is central to its role. Supporting Evidence: PMID:10502458 We conclude that the GHR associates with Jak1, Jak2 and Tyk2 in human liver. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0005143 interleukin-12 receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: JAK2 binds the cytoplasmic domain of a specific cytokine-family receptor. Reason: JAK2 constitutively associates via its FERM domain with membrane-proximal box1/box2 of the growth hormone receptor and IL-12 receptor beta 2, among others; this receptor binding is central to its role. Supporting Evidence: PMID:10502458 We conclude that the GHR associates with Jak1, Jak2 and Tyk2 in human liver. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0005143 interleukin-12 receptor binding | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 binds the cytoplasmic domain of a specific cytokine-family receptor. Reason: JAK2 constitutively associates via its FERM domain with membrane-proximal box1/box2 of the growth hormone receptor and IL-12 receptor beta 2, among others; this receptor binding is central to its role. Supporting Evidence: PMID:10502458 We conclude that the GHR associates with Jak1, Jak2 and Tyk2 in human liver. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0005515 protein binding | IPI PMID:11679576 hTid-1, a human DnaJ protein, modulates the interferon signa... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:11679576 hTid-1, a human DnaJ protein, modulates the interferon signa... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:11694501 TYK2 and JAK2 are substrates of protein-tyrosine phosphatase... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:11970898 PTP1B regulates leptin signal transduction in vivo. | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:15821101 Mechanism of protein tyrosine phosphatase 1B-mediated inhibi... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16437163 Growth factor pleiotropy is controlled by a receptor Tyr/Ser... | MODIFY | Summary: JAK2 binds the cytoplasmic domain of a cytokine receptor chain. Reason: Following the protein-binding policy, replace with the informative term; the partner is a cytokine receptor subunit (IL-5R alpha, beta c, MPL or gp130) whose box1 region binds the JAK2 FERM domain. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:18692472 The structure of the GM-CSF receptor complex reveals a disti... | MODIFY | Summary: JAK2 binds the cytoplasmic domain of a cytokine receptor chain. Reason: Following the protein-binding policy, replace with the informative term; the partner is a cytokine receptor subunit (IL-5R alpha, beta c, MPL or gp130) whose box1 region binds the JAK2 FERM domain. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. |
| GO:0005515 protein binding | IPI PMID:19234114 Hepcidin-induced internalization of ferroportin requires bin... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:20353823 Stat1 mediates an auto-regulation of hsp90beta gene in heat ... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21119685 Notch-induced Asb2 expression promotes protein ubiquitinatio... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21806020 The metastasis-promoting phosphatase PRL-3 shows activity to... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:24931576 Mpl traffics to the cell surface through conventional and un... | MODIFY | Summary: JAK2 binds the cytoplasmic domain of a cytokine receptor chain. Reason: Following the protein-binding policy, replace with the informative term; the partner is a cytokine receptor subunit (IL-5R alpha, beta c, MPL or gp130) whose box1 region binds the JAK2 FERM domain. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. |
| GO:0005515 protein binding | IPI PMID:25092874 RHEX, a novel regulator of human erythroid progenitor cell e... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26175413 CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibi... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26175413 CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibi... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30413785 ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32750333 Complex Autoinflammatory Syndrome Unveils Fundamental Princi... | REMOVE | Summary: Physical interaction reported with a regulator, substrate, phosphatase or chaperone of JAK2. Reason: Bare protein binding is uninformative under the protein-binding policy. The reported partners (phosphatases such as PTP1B, chaperones, other JAKs, E3 ligase components, signaling partners) act on or with JAK2, but the generic term does not describe JAK2's function. Removal does not mean the interaction is false. |
| GO:0005515 protein binding | IPI PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS... | MODIFY | Summary: JAK2 binds the cytoplasmic domain of a cytokine receptor chain. Reason: Following the protein-binding policy, replace with the informative term; the partner is a cytokine receptor subunit (IL-5R alpha, beta c, MPL or gp130) whose box1 region binds the JAK2 FERM domain. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. |
| GO:0005515 protein binding | IPI PMID:9516124 JAK2 and JAK1 constitutively associate with an interleukin-5... | MODIFY | Summary: JAK2 binds the cytoplasmic domain of a cytokine receptor chain. Reason: Following the protein-binding policy, replace with the informative term; the partner is a cytokine receptor subunit (IL-5R alpha, beta c, MPL or gp130) whose box1 region binds the JAK2 FERM domain. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: ATP binding by the kinase domain. Reason: Implied by the tyrosine kinase activity; a mechanistic sub-feature rather than an informative function. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity |
| GO:0005634 nucleus | IDA PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and T... | KEEP AS NON CORE | Summary: A nuclear/chromatin pool of JAK2 has been reported. Reason: Nuclear JAK2 phosphorylating H3Y41 is reported in haematopoietic cells; this is a secondary location relative to the receptor-associated cytoplasmic pool. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0005634 nucleus | IDA PMID:19783980 JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from... | KEEP AS NON CORE | Summary: A nuclear/chromatin pool of JAK2 has been reported. Reason: Nuclear JAK2 phosphorylating H3Y41 is reported in haematopoietic cells; this is a secondary location relative to the receptor-associated cytoplasmic pool. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0005634 nucleus | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: A nuclear/chromatin pool of JAK2 has been reported. Reason: Nuclear JAK2 phosphorylating H3Y41 is reported in haematopoietic cells; this is a secondary location relative to the receptor-associated cytoplasmic pool. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: A nuclear/chromatin pool of JAK2 has been reported. Reason: Nuclear JAK2 phosphorylating H3Y41 is reported in haematopoietic cells; this is a secondary location relative to the receptor-associated cytoplasmic pool. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3215391 | KEEP AS NON CORE | Summary: A nuclear/chromatin pool of JAK2 has been reported. Reason: Nuclear JAK2 phosphorylating H3Y41 is reported in haematopoietic cells; this is a secondary location relative to the receptor-associated cytoplasmic pool. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0005737 cytoplasm | IDA PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and T... | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005768 endosome | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ARBA-based endosome location. Reason: Receptor-JAK2 complexes are internalized after stimulation, so association with the cytoplasmic face of endosomes is plausible, but not a defining location. Supporting Evidence: PMID:15899890 Confocal microscopy indicates that TpoR colocalizes partially with recycling transferrin in Ba/F3 cells. |
| GO:0005829 cytosol | IBA GO_REF:0000033 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | IEA GO_REF:0000107 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1067651 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1067659 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1067688 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112510 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112514 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112565 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112602 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112604 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112690 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112703 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112708 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112727 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112755 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1168445 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1168459 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1168894 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1169192 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1170539 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1364044 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1370500 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1370505 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433418 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433451 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433456 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470009 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470010 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470012 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1671687 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1675473 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-447130 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-447226 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-447252 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448427 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-449976 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-450031 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453104 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453111 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-508247 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5696482 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783524 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783530 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783552 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783556 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6783681 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784189 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784204 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6785821 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6785898 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786050 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786058 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786070 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786072 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786092 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786095 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786096 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786101 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786110 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786114 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786124 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788571 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788582 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788628 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6809140 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873918 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873919 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873921 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873922 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873924 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873926 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-873927 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-877269 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-879907 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-879909 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-879910 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-879925 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-879930 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-879934 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-879942 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950128 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950210 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950269 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950340 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950405 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950423 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950441 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950448 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950453 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950485 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950518 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950537 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950757 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8952749 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8952807 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8952823 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8981093 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983518 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983519 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983834 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983835 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983841 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983845 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983870 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983872 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983876 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983878 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983983 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983996 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984001 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984012 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984014 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984021 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984023 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9012657 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9021627 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027272 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027273 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027275 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027281 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9029150 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909552 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-909738 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-912527 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-912757 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913370 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913371 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913374 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913424 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913451 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-914036 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-914182 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-921155 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670412 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670413 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670416 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670417 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670418 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670426 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9674816 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9678561 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9705738 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9707977 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9709454 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9732729 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9732738 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9732753 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-976991 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-982768 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-982775 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-982778 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-982792 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-982807 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-982810 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9958871 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9958877 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9958878 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-997237 | ACCEPT | Summary: JAK2 is a soluble cytoplasmic kinase recruited to receptor tails. Reason: JAK2 lacks membrane-spanning segments and is a cytoplasmic protein; Reactome places its receptor- associated reactions in the cytosol and UniProt records a cytoplasmic location by direct evidence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors PMID:10502458 Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. |
| GO:0005886 plasma membrane | NAS PMID:1495999 Molecular basis of the membrane-anchored and two soluble iso... | MODIFY | Summary: JAK2 associates with the plasma membrane via cytokine receptors. Reason: True but less specific than warranted; JAK2 is a cytosolic-side peripheral protein of the plasma membrane, with no extracellular exposure. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0005886 plasma membrane | NAS PMID:1702217 Molecular cloning of a second subunit of the receptor for hu... | MODIFY | Summary: JAK2 associates with the plasma membrane via cytokine receptors. Reason: True but less specific than warranted; JAK2 is a cytosolic-side peripheral protein of the plasma membrane, with no extracellular exposure. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0005895 interleukin-5 receptor complex | NAS PMID:1495999 Molecular basis of the membrane-anchored and two soluble iso... | KEEP AS NON CORE | Summary: JAK2 associates with cytokine receptor complexes (IL-5R, GM-CSF receptor). Reason: JAK2 binds the beta c and IL-5R alpha chains and is functionally part of these signaling complexes; it is an associated kinase rather than a ligand-binding subunit. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:9516124 JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively. |
| GO:0005901 caveola | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Rodent data place JAK2 in caveolae/membrane rafts. Reason: Receptor-associated JAK2 can partition into raft/caveolar membrane domains in some cell types; a contextual sublocation of its plasma-membrane pool. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0005901 caveola | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Rodent data place JAK2 in caveolae/membrane rafts. Reason: Receptor-associated JAK2 can partition into raft/caveolar membrane domains in some cell types; a contextual sublocation of its plasma-membrane pool. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0006338 chromatin remodeling | IEA GO_REF:0000108 | KEEP AS NON CORE | Summary: H3Y41 phosphorylation by nuclear JAK2 excludes HP1alpha from chromatin. Reason: Supported by the nuclear H3Y41 study; a secondary nuclear role. Supporting Evidence: PMID:19783980 Phosphorylation of H3Y41 by JAK2 prevents this binding. |
| GO:0006915 apoptotic process | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: JAK2 implicated in apoptotic signaling from rodent data. Reason: JAK2 influences cell survival through cytokine signaling but is not part of the apoptotic machinery; effects on apoptosis are indirect and context dependent. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0006979 response to oxidative stress | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: JAK2 activity or stability changes in response to a chemical stimulus. Reason: These terms reflect JAK2 being affected by the stimulus (e.g. Hsp90 inhibition with geldanamycin causing proteasomal degradation of JAKs) rather than JAK2 executing a response to it. Supporting Evidence: PMID:16280321 Hsp90 was required for signal transducers and activators of transcription 1 phosphorylation, and in its absence, Janus kinase (JAK) 1/2 were degraded by the proteosome. |
| GO:0007155 cell adhesion | IDA PMID:23160466 JAK2V617F activates Lu/BCAM-mediated red cell adhesion in po... | MARK AS OVER ANNOTATED | Summary: JAK2 linked to adhesion or cytoskeletal processes. Reason: The evidence describes JAK2 signaling upstream of adhesion (for example V617F-driven Rap1/Akt activation of Lu/BCAM in polycythemia vera RBCs, or GH-induced actin remodeling), not JAK2 acting as adhesion or actin machinery. Supporting Evidence: PMID:23160466 Our findings reveal a novel EpoR-independent Rap1/Akt signaling pathway that is activated by JAK2V617F in circulating PV RBCs and responsible for Lu/BCAM activation. |
| GO:0007165 signal transduction | IEA GO_REF:0000107 | MODIFY | Summary: JAK2 acts in signal transduction downstream of cytokine receptors. Reason: True but too general; JAK2 acts specifically in cell surface receptor signaling via JAK-STAT, already annotated. Proposed replacements: cell surface receptor signaling pathway via JAK-STAT Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0007165 signal transduction | ISS GO_REF:0000024 | MODIFY | Summary: JAK2 acts in signal transduction downstream of cytokine receptors. Reason: True but too general; JAK2 acts specifically in cell surface receptor signaling via JAK-STAT, already annotated. Proposed replacements: cell surface receptor signaling pathway via JAK-STAT Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0007167 enzyme-linked receptor protein signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Cytokine receptors use JAK2 as their associated kinase. Reason: Defensible broad grouping; the specific cytokine receptor JAK-STAT pathway terms are accepted. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0007204 positive regulation of cytosolic calcium ion concentration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IBA GO_REF:0000033 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:11294841 Signaling pathways recruited by the cardiotrophin-like cytok... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:18692472 The structure of the GM-CSF receptor complex reveals a disti... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:31145836 Physical proximity and functional cooperation of glycoprotei... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:9030543 Signaling of the cardiotrophin-1 receptor. Evidence for a th... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:9188471 Signaling of type II oncostatin M receptor. | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:9516124 JAK2 and JAK1 constitutively associate with an interleukin-5... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IEA GO_REF:0000120 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0007498 mesoderm development | TAS PMID:9590174 Jak2 deficiency defines an essential developmental checkpoin... | MARK AS OVER ANNOTATED | Summary: Statement linking Jak2 deficiency to development. Reason: The knockout defect is a block in definitive hematopoiesis, not in mesoderm development; primitive erythrocytes and multilineage progenitors form. Supporting Evidence: PMID:9590174 Primitive erythrocytes are found, but definitive erythropoiesis is absent. |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: JAK2-dependent cytokine/growth-factor signaling affects cell proliferation or migration. Reason: Proliferation of hematopoietic and other cells downstream of cytokine receptors depends on JAK2, but the proliferative outcome is downstream of its kinase function. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0008285 negative regulation of cell population proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: JAK2-dependent cytokine/growth-factor signaling affects cell proliferation or migration. Reason: Proliferation of hematopoietic and other cells downstream of cytokine receptors depends on JAK2, but the proliferative outcome is downstream of its kinase function. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: JAK2 implicated in apoptotic signaling from rodent data. Reason: JAK2 influences cell survival through cytokine signaling but is not part of the apoptotic machinery; effects on apoptosis are indirect and context dependent. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0009755 hormone-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0009898 cytoplasmic side of plasma membrane | IC PMID:20974963 Thymic stromal lymphopoietin-mediated STAT5 phosphorylation ... | ACCEPT | Summary: JAK2 is bound to the cytoplasmic tails of cytokine receptors at the inner face of the plasma membrane. Reason: JAK2 has no transmembrane segment; it is peripherally attached to the cytoplasmic face of the plasma membrane through FERM-domain binding to receptor box1/box2 motifs. This is its principal functional location. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0009898 cytoplasmic side of plasma membrane | IDA PMID:12023369 A receptor for the heterodimeric cytokine IL-23 is composed ... | ACCEPT | Summary: JAK2 is bound to the cytoplasmic tails of cytokine receptors at the inner face of the plasma membrane. Reason: JAK2 has no transmembrane segment; it is peripherally attached to the cytoplasmic face of the plasma membrane through FERM-domain binding to receptor box1/box2 motifs. This is its principal functional location. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0009898 cytoplasmic side of plasma membrane | IDA PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS... | ACCEPT | Summary: JAK2 is bound to the cytoplasmic tails of cytokine receptors at the inner face of the plasma membrane. Reason: JAK2 has no transmembrane segment; it is peripherally attached to the cytoplasmic face of the plasma membrane through FERM-domain binding to receptor box1/box2 motifs. This is its principal functional location. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0010572 positive regulation of platelet activation | IDA PMID:31145836 Physical proximity and functional cooperation of glycoprotei... | KEEP AS NON CORE | Summary: JAK2 signaling modulates adhesion or platelet activation. Reason: Reported outcomes of GH, gp130/IL-6 and other JAK2-dependent signaling in neutrophils, platelets and other cells; downstream and context-specific. Supporting Evidence: PMID:10925297 Pituitary GH triggered the tyrosine phosphorylation of Janus kinase 2 (Jak2) and STAT3 in neutrophils. |
| GO:0010667 negative regulation of cardiac muscle cell apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 signaling modulates apoptosis in various cell types. Reason: Survival signaling by cytokines (EPO, GH, leptin, gp130 family) through JAK2-STAT regulates apoptosis indirectly; acceptable as a non-core downstream consequence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0010811 positive regulation of cell-substrate adhesion | IDA PMID:10925297 Regulation of neutrophil adhesion by pituitary growth hormon... | KEEP AS NON CORE | Summary: JAK2 signaling modulates adhesion or platelet activation. Reason: Reported outcomes of GH, gp130/IL-6 and other JAK2-dependent signaling in neutrophils, platelets and other cells; downstream and context-specific. Supporting Evidence: PMID:10925297 Pituitary GH triggered the tyrosine phosphorylation of Janus kinase 2 (Jak2) and STAT3 in neutrophils. |
| GO:0012505 endomembrane system | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: UniProt (by similarity) records JAK2 as a peripheral endomembrane protein. Reason: JAK2 binds receptors during their biosynthetic trafficking and promotes their surface delivery (e.g. TpoR), consistent with association with endomembranes; not its main functional site. Supporting Evidence: PMID:15899890 JAK2 and Tyk2 strongly promote cell surface localization and enhance total protein levels of the TpoR. |
| GO:0016020 membrane | IEA GO_REF:0000002 | MODIFY | Summary: JAK2 associates with the plasma membrane via cytokine receptors. Reason: True but less specific than warranted; JAK2 is a cytosolic-side peripheral protein of the plasma membrane, with no extracellular exposure. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0019221 cytokine-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:11294841 Signaling pathways recruited by the cardiotrophin-like cytok... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:8609418 IL-13 induces phosphorylation and activation of JAK2 Janus k... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:9030543 Signaling of the cardiotrophin-1 receptor. Evidence for a th... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0019221 cytokine-mediated signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0019221 cytokine-mediated signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0019221 cytokine-mediated signaling pathway | TAS Reactome:R-HSA-512988 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0019221 cytokine-mediated signaling pathway | TAS Reactome:R-HSA-6785807 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0019897 extrinsic component of plasma membrane | IDA PMID:8007942 JAK2 associates with the beta c chain of the receptor for gr... | MODIFY | Summary: JAK2 is a peripheral membrane protein associated with receptor complexes. Reason: Correct, but JAK2 associates with the cytoplasmic side specifically; the more precise term already carried by the gene is preferred. Proposed replacements: extrinsic component of cytoplasmic side of plasma membrane Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0019901 protein kinase binding | IDA PMID:10925297 Regulation of neutrophil adhesion by pituitary growth hormon... | MARK AS OVER ANNOTATED | Summary: Association of JAK2 with focal adhesion kinase in GH-stimulated neutrophils. Reason: The study reports that the JAK2-FAK association is bridged by STAT3, so it does not show direct binding of JAK2 to a protein kinase. Supporting Evidence: PMID:10925297 Immunoprecipitation experiments revealed a physical association of Jak2 with p125FAK via STAT3 in vivo. |
| GO:0020037 heme binding | IDA PMID:21036157 Heme controls the regulation of protein tyrosine kinases Jak... | KEEP AS NON CORE | Summary: JAK2 binds heme, which modulates its tyrosine phosphorylation. Reason: Direct heme binding is reported via CP motifs; a regulatory property, not the core function. Supporting Evidence: PMID:21036157 Further experiments showed that Jak2 and Src bind to heme |
| GO:0022407 regulation of cell-cell adhesion | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: JAK2 signaling modulates adhesion or platelet activation. Reason: Reported outcomes of GH, gp130/IL-6 and other JAK2-dependent signaling in neutrophils, platelets and other cells; downstream and context-specific. Supporting Evidence: PMID:10925297 Pituitary GH triggered the tyrosine phosphorylation of Janus kinase 2 (Jak2) and STAT3 in neutrophils. |
| GO:0022408 negative regulation of cell-cell adhesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 signaling modulates adhesion or platelet activation. Reason: Reported outcomes of GH, gp130/IL-6 and other JAK2-dependent signaling in neutrophils, platelets and other cells; downstream and context-specific. Supporting Evidence: PMID:10925297 Pituitary GH triggered the tyrosine phosphorylation of Janus kinase 2 (Jak2) and STAT3 in neutrophils. |
| GO:0030041 actin filament polymerization | NAS PMID:10925297 Regulation of neutrophil adhesion by pituitary growth hormon... | MARK AS OVER ANNOTATED | Summary: JAK2 linked to adhesion or cytoskeletal processes. Reason: The evidence describes JAK2 signaling upstream of adhesion (for example V617F-driven Rap1/Akt activation of Lu/BCAM in polycythemia vera RBCs, or GH-induced actin remodeling), not JAK2 acting as adhesion or actin machinery. Supporting Evidence: PMID:23160466 Our findings reveal a novel EpoR-independent Rap1/Akt signaling pathway that is activated by JAK2V617F in circulating PV RBCs and responsible for Lu/BCAM activation. |
| GO:0030154 cell differentiation | ISS GO_REF:0000024 | MODIFY | Summary: Generic cell differentiation from mouse Jak2. Reason: Too general; the best-supported differentiation role is erythrocyte differentiation, already annotated. Proposed replacements: erythrocyte differentiation Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0030218 erythrocyte differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: JAK2 is required for definitive erythropoiesis. Reason: Jak2 knockout embryos lack definitive erythropoiesis because EPO receptor signaling fails; the differentiation outcome is downstream of JAK2's signaling function. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0030218 erythrocyte differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 is required for definitive erythropoiesis. Reason: Jak2 knockout embryos lack definitive erythropoiesis because EPO receptor signaling fails; the differentiation outcome is downstream of JAK2's signaling function. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0030218 erythrocyte differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: JAK2 is required for definitive erythropoiesis. Reason: Jak2 knockout embryos lack definitive erythropoiesis because EPO receptor signaling fails; the differentiation outcome is downstream of JAK2's signaling function. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0030335 positive regulation of cell migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2-dependent cytokine/growth-factor signaling affects cell proliferation or migration. Reason: Proliferation of hematopoietic and other cells downstream of cytokine receptors depends on JAK2, but the proliferative outcome is downstream of its kinase function. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex | IDA PMID:27396825 Conformational Changes in the GM-CSF Receptor Suggest a Mole... | KEEP AS NON CORE | Summary: JAK2 associates with cytokine receptor complexes (IL-5R, GM-CSF receptor). Reason: JAK2 binds the beta c and IL-5R alpha chains and is functionally part of these signaling complexes; it is an associated kinase rather than a ligand-binding subunit. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:9516124 JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively. |
| GO:0030546 signaling receptor activator activity | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Transfer of signaling receptor activator activity from mouse Jak2. Reason: JAK2 activates cytokine receptor signaling as the receptor-associated kinase, not as an extracellular or ligand-like activator of a receptor. Its activity is captured by tyrosine kinase activity and cytokine receptor binding. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0030546 signaling receptor activator activity | ISS PMID:26227742 Inhibition of JAK2 attenuates the increase in inflammatory m... | MARK AS OVER ANNOTATED | Summary: Transfer of signaling receptor activator activity from mouse Jak2. Reason: JAK2 activates cytokine receptor signaling as the receptor-associated kinase, not as an extracellular or ligand-like activator of a receptor. Its activity is captured by tyrosine kinase activity and cytokine receptor binding. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0031103 axon regeneration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Developmental outcome downstream of JAK2-dependent hormone or cytokine signaling. Reason: JAK2 mediates prolactin, GH and neurotrophic cytokine signaling that influences these developmental and regenerative processes; these are downstream, context-specific outcomes. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IC PMID:7528775 Interleukin 12 (IL-12) induces tyrosine phosphorylation of J... | ACCEPT | Summary: JAK2 is bound to the cytoplasmic tails of cytokine receptors at the inner face of the plasma membrane. Reason: JAK2 has no transmembrane segment; it is peripherally attached to the cytoplasmic face of the plasma membrane through FERM-domain binding to receptor box1/box2 motifs. This is its principal functional location. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IDA PMID:8007942 JAK2 associates with the beta c chain of the receptor for gr... | ACCEPT | Summary: JAK2 is bound to the cytoplasmic tails of cytokine receptors at the inner face of the plasma membrane. Reason: JAK2 has no transmembrane segment; it is peripherally attached to the cytoplasmic face of the plasma membrane through FERM-domain binding to receptor box1/box2 motifs. This is its principal functional location. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0031234 extrinsic component of cytoplasmic side of plasma membrane | IEA GO_REF:0000117 | ACCEPT | Summary: JAK2 is bound to the cytoplasmic tails of cytokine receptors at the inner face of the plasma membrane. Reason: JAK2 has no transmembrane segment; it is peripherally attached to the cytoplasmic face of the plasma membrane through FERM-domain binding to receptor box1/box2 motifs. This is its principal functional location. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0031663 lipopolysaccharide-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0031663 lipopolysaccharide-mediated signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0031702 type 1 angiotensin receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported association of JAK2 with a non-cytokine receptor or signaling adaptor. Reason: JAK2 has been reported to associate with receptors and adaptors outside the cytokine receptor family (angiotensin AT1, nicotinic receptor, IRS proteins, PI3K, SOCS SH2 domains). These are context-dependent interactions secondary to its cytokine-receptor kinase role. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0031904 endosome lumen | TAS Reactome:R-HSA-1170539 | REMOVE | Summary: Reactome places JAK2 with the internalized prolactin receptor in the endosome lumen. Reason: JAK2 is a cytoplasmic protein bound to receptor cytoplasmic tails; it cannot be in the lumen of an endosome, which is topologically equivalent to the extracellular side. The compartment assignment is a Reactome modeling artifact of the internalized complex. Supporting Evidence: PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0031959 nuclear receptor-mediated mineralocorticoid signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0032024 positive regulation of insulin secretion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Metabolic/endocrine outcome of JAK2 signaling (mouse data). Reason: Adipose and endocrine JAK2 signaling affects thermogenesis and insulin secretion in mice; downstream physiological outcomes. Supporting Evidence: PMID:26515423 JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. |
| GO:0032731 positive regulation of interleukin-1 beta production | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0032731 positive regulation of interleukin-1 beta production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0032760 positive regulation of tumor necrosis factor production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0032760 positive regulation of tumor necrosis factor production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0033130 acetylcholine receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported association of JAK2 with a non-cytokine receptor or signaling adaptor. Reason: JAK2 has been reported to associate with receptors and adaptors outside the cytokine receptor family (angiotensin AT1, nicotinic receptor, IRS proteins, PI3K, SOCS SH2 domains). These are context-dependent interactions secondary to its cytokine-receptor kinase role. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0033194 response to hydroperoxide | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: JAK2 activity or stability changes in response to a chemical stimulus. Reason: These terms reflect JAK2 being affected by the stimulus (e.g. Hsp90 inhibition with geldanamycin causing proteasomal degradation of JAKs) rather than JAK2 executing a response to it. Supporting Evidence: PMID:16280321 Hsp90 was required for signal transducers and activators of transcription 1 phosphorylation, and in its absence, Janus kinase (JAK) 1/2 were degraded by the proteosome. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IDA PMID:8609418 IL-13 induces phosphorylation and activation of JAK2 Janus k... | KEEP AS NON CORE | Summary: JAK2 activation observed upon cytokine stimulation. Reason: JAK2 phosphorylation is observed in response to the cytokine; the specific cytokine receptor JAK-STAT signaling terms capture the core role. Supporting Evidence: PMID:8609418 We show that JAK2 kinase is rapidly phosphorylated and activated in response to IL-13. |
| GO:0034332 adherens junction organization | TAS Reactome:R-HSA-418990 | MARK AS OVER ANNOTATED | Summary: JAK2 linked to adhesion or cytoskeletal processes. Reason: The evidence describes JAK2 signaling upstream of adhesion (for example V617F-driven Rap1/Akt activation of Lu/BCAM in polycythemia vera RBCs, or GH-induced actin remodeling), not JAK2 acting as adhesion or actin machinery. Supporting Evidence: PMID:23160466 Our findings reveal a novel EpoR-independent Rap1/Akt signaling pathway that is activated by JAK2V617F in circulating PV RBCs and responsible for Lu/BCAM activation. |
| GO:0034612 response to tumor necrosis factor | IDA PMID:8609418 IL-13 induces phosphorylation and activation of JAK2 Janus k... | KEEP AS NON CORE | Summary: JAK2 activation observed upon cytokine stimulation. Reason: JAK2 phosphorylation is observed in response to the cytokine; the specific cytokine receptor JAK-STAT signaling terms capture the core role. Supporting Evidence: PMID:8609418 We show that JAK2 kinase is rapidly phosphorylated and activated in response to IL-13. |
| GO:0035166 post-embryonic hemopoiesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 is required for definitive erythropoiesis. Reason: Jak2 knockout embryos lack definitive erythropoiesis because EPO receptor signaling fails; the differentiation outcome is downstream of JAK2's signaling function. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0035401 histone H3Y41 kinase activity | IDA PMID:19783980 JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from... | KEEP AS NON CORE | Summary: Nuclear JAK2 was reported to phosphorylate histone H3 Tyr41. Reason: Direct in vitro and cellular evidence supports H3Y41 phosphorylation by JAK2 in haematopoietic cells, but this nuclear activity is secondary to its canonical cytokine-receptor function. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0035556 intracellular signal transduction | IBA GO_REF:0000033 | MODIFY | Summary: JAK2 acts in signal transduction downstream of cytokine receptors. Reason: True but too general; JAK2 acts specifically in cell surface receptor signaling via JAK-STAT, already annotated. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: PANTHER:PTN001562978 SUPPORTS TRANSFER JAK-family ancestral node; signaling role conserved across JAK1/2/3/TYK2, but the specific JAK-STAT receptor pathway term is more informative. Proposed replacements: cell surface receptor signaling pathway via JAK-STAT Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0035556 intracellular signal transduction | IEA GO_REF:0000002 | MODIFY | Summary: JAK2 acts in signal transduction downstream of cytokine receptors. Reason: True but too general; JAK2 acts specifically in cell surface receptor signaling via JAK-STAT, already annotated. Proposed replacements: cell surface receptor signaling pathway via JAK-STAT Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0035556 intracellular signal transduction | ISS GO_REF:0000024 | MODIFY | Summary: JAK2 acts in signal transduction downstream of cytokine receptors. Reason: True but too general; JAK2 acts specifically in cell surface receptor signaling via JAK-STAT, already annotated. Proposed replacements: cell surface receptor signaling pathway via JAK-STAT Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0035556 intracellular signal transduction | TAS PMID:9590174 Jak2 deficiency defines an essential developmental checkpoin... | MODIFY | Summary: JAK2 acts in signal transduction downstream of cytokine receptors. Reason: True but too general; JAK2 acts specifically in cell surface receptor signaling via JAK-STAT, already annotated. Proposed replacements: cell surface receptor signaling pathway via JAK-STAT Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0035722 interleukin-12-mediated signaling pathway | IDA PMID:7528775 Interleukin 12 (IL-12) induces tyrosine phosphorylation of J... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0038043 interleukin-5-mediated signaling pathway | IDA PMID:7613138 The interleukin-5/receptor interaction activates Lyn and Jak... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0038043 interleukin-5-mediated signaling pathway | NAS PMID:7888666 Interleukin-5 signaling in human eosinophils involves JAK2 t... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0038065 collagen-activated signaling pathway | IMP PMID:31145836 Physical proximity and functional cooperation of glycoprotei... | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0038155 interleukin-23-mediated signaling pathway | IDA PMID:12023369 A receptor for the heterodimeric cytokine IL-23 is composed ... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0038156 interleukin-3-mediated signaling pathway | IDA PMID:8007942 JAK2 associates with the beta c chain of the receptor for gr... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0038157 granulocyte-macrophage colony-stimulating factor signaling pathway | IDA PMID:18692472 The structure of the GM-CSF receptor complex reveals a disti... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0038162 erythropoietin-mediated signaling pathway | IDA PMID:9657743 Erythropoietin induces tyrosine phosphorylation of Jak2, STA... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0038163 thrombopoietin-mediated signaling pathway | IDA PMID:15899890 Janus kinases affect thrombopoietin receptor cell surface lo... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0038165 oncostatin-M-mediated signaling pathway | IDA PMID:9188471 Signaling of type II oncostatin M receptor. | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0042102 positive regulation of T cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2-dependent cytokine/growth-factor signaling affects cell proliferation or migration. Reason: Proliferation of hematopoietic and other cells downstream of cytokine receptors depends on JAK2, but the proliferative outcome is downstream of its kinase function. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0042169 SH2 domain binding | IPI PMID:9727029 Interaction of human suppressor of cytokine signaling (SOCS)... | KEEP AS NON CORE | Summary: Reported association of JAK2 with a non-cytokine receptor or signaling adaptor. Reason: JAK2 has been reported to associate with receptors and adaptors outside the cytokine receptor family (angiotensin AT1, nicotinic receptor, IRS proteins, PI3K, SOCS SH2 domains). These are context-dependent interactions secondary to its cytokine-receptor kinase role. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0042307 positive regulation of protein import into nucleus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0042393 histone binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: InterPro-based histone binding. Reason: Consistent with the reported nuclear phosphorylation of histone H3 Tyr41, a non-core activity. Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 trans-autophosphorylates its activation loop and directly phosphorylates STATs. Reason: Activation-loop Tyr1007 autophosphorylation is required for activity, and JAK2 directly phosphorylates recruited STATs; these describe steps JAK2 itself performs. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0042802 identical protein binding | IPI PMID:21841788 The pseudokinase domain of JAK2 is a dual-specificity protei... | KEEP AS NON CORE | Summary: JAK2 pseudokinase (JH2) domains self-associate in structural and biochemical studies. Reason: Self-association of JH2/JAK2 is relevant to activation and to V617F-driven dimerization but is not the core activity. Supporting Evidence: PMID:22820988 Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. |
| GO:0042802 identical protein binding | IPI PMID:22820988 Crystal structures of the JAK2 pseudokinase domain and the p... | KEEP AS NON CORE | Summary: JAK2 pseudokinase (JH2) domains self-associate in structural and biochemical studies. Reason: Self-association of JH2/JAK2 is relevant to activation and to V617F-driven dimerization but is not the core activity. Supporting Evidence: PMID:22820988 Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. |
| GO:0042976 activation of Janus kinase activity | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 trans-autophosphorylates its activation loop and directly phosphorylates STATs. Reason: Activation-loop Tyr1007 autophosphorylation is required for activity, and JAK2 directly phosphorylates recruited STATs; these describe steps JAK2 itself performs. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0042981 regulation of apoptotic process | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: JAK2 signaling modulates apoptosis in various cell types. Reason: Survival signaling by cytokines (EPO, GH, leptin, gp130 family) through JAK2-STAT regulates apoptosis indirectly; acceptable as a non-core downstream consequence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0043065 positive regulation of apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 signaling modulates apoptosis in various cell types. Reason: Survival signaling by cytokines (EPO, GH, leptin, gp130 family) through JAK2-STAT regulates apoptosis indirectly; acceptable as a non-core downstream consequence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0043066 negative regulation of apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 signaling modulates apoptosis in various cell types. Reason: Survival signaling by cytokines (EPO, GH, leptin, gp130 family) through JAK2-STAT regulates apoptosis indirectly; acceptable as a non-core downstream consequence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0043410 positive regulation of MAPK cascade | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0043524 negative regulation of neuron apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 signaling modulates apoptosis in various cell types. Reason: Survival signaling by cytokines (EPO, GH, leptin, gp130 family) through JAK2-STAT regulates apoptosis indirectly; acceptable as a non-core downstream consequence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0043548 phosphatidylinositol 3-kinase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported association of JAK2 with a non-cytokine receptor or signaling adaptor. Reason: JAK2 has been reported to associate with receptors and adaptors outside the cytokine receptor family (angiotensin AT1, nicotinic receptor, IRS proteins, PI3K, SOCS SH2 domains). These are context-dependent interactions secondary to its cytokine-receptor kinase role. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0043560 insulin receptor substrate binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported association of JAK2 with a non-cytokine receptor or signaling adaptor. Reason: JAK2 has been reported to associate with receptors and adaptors outside the cytokine receptor family (angiotensin AT1, nicotinic receptor, IRS proteins, PI3K, SOCS SH2 domains). These are context-dependent interactions secondary to its cytokine-receptor kinase role. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0043687 post-translational protein modification | IDA PMID:19783980 JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from... | MODIFY | Summary: Post-translational modification by JAK2 (histone H3 Tyr41 phosphorylation). Reason: Overly general; the modification JAK2 catalyses is tyrosine phosphorylation of proteins. Proposed replacements: peptidyl-tyrosine phosphorylation Supporting Evidence: PMID:19783980 human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3 |
| GO:0045121 membrane raft | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Rodent data place JAK2 in caveolae/membrane rafts. Reason: Receptor-associated JAK2 can partition into raft/caveolar membrane domains in some cell types; a contextual sublocation of its plasma-membrane pool. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0045121 membrane raft | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Rodent data place JAK2 in caveolae/membrane rafts. Reason: Receptor-associated JAK2 can partition into raft/caveolar membrane domains in some cell types; a contextual sublocation of its plasma-membrane pool. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0045348 positive regulation of MHC class II biosynthetic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0045348 positive regulation of MHC class II biosynthetic process | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0045428 regulation of nitric oxide biosynthetic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0045428 regulation of nitric oxide biosynthetic process | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0045429 positive regulation of nitric oxide biosynthetic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0045597 positive regulation of cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Developmental outcome downstream of JAK2-dependent hormone or cytokine signaling. Reason: JAK2 mediates prolactin, GH and neurotrophic cytokine signaling that influences these developmental and regenerative processes; these are downstream, context-specific outcomes. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0045893 positive regulation of DNA-templated transcription | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 promotes STAT-dependent transcription indirectly. Reason: JAK2 phosphorylates STATs that activate transcription; the transcriptional effect is indirect. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: JAK2 promotes STAT-dependent transcription indirectly. Reason: JAK2 phosphorylates STATs that activate transcription; the transcriptional effect is indirect. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: JAK2 promotes STAT-dependent transcription indirectly. Reason: JAK2 phosphorylates STATs that activate transcription; the transcriptional effect is indirect. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: JAK2 promotes STAT-dependent transcription indirectly. Reason: JAK2 phosphorylates STATs that activate transcription; the transcriptional effect is indirect. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0046425 regulation of receptor signaling pathway via JAK-STAT | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: JAK2 as a regulator of JAK-STAT/GH receptor signaling. Reason: JAK2 is the core kinase of these pathways rather than a regulator of them; participation is already captured by the accepted pathway terms. JH2-mediated autoinhibition is intramolecular. Supporting Evidence: PMID:21841788 Here we show that JH2 is a dual-specificity protein kinase that phosphorylates two negative regulatory sites in JAK2: Ser523 and Tyr570. |
| GO:0046677 response to antibiotic | IDA PMID:16280321 The heat shock protein 90-CDC37 chaperone complex is require... | MARK AS OVER ANNOTATED | Summary: JAK2 activity or stability changes in response to a chemical stimulus. Reason: These terms reflect JAK2 being affected by the stimulus (e.g. Hsp90 inhibition with geldanamycin causing proteasomal degradation of JAKs) rather than JAK2 executing a response to it. Supporting Evidence: PMID:16280321 Hsp90 was required for signal transducers and activators of transcription 1 phosphorylation, and in its absence, Janus kinase (JAK) 1/2 were degraded by the proteosome. |
| GO:0046777 protein autophosphorylation | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 trans-autophosphorylates its activation loop and directly phosphorylates STATs. Reason: Activation-loop Tyr1007 autophosphorylation is required for activity, and JAK2 directly phosphorylates recruited STATs; these describe steps JAK2 itself performs. Supporting Evidence: PMID:9111318 Mutation of Y1007, or both Y1007 and Y1008, to phenylalanine essentially eliminated kinase activity PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. |
| GO:0048008 platelet-derived growth factor receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0048861 leukemia inhibitory factor signaling pathway | IDA PMID:11294841 Signaling pathways recruited by the cardiotrophin-like cytok... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0050727 regulation of inflammatory response | IDA PMID:10925297 Regulation of neutrophil adhesion by pituitary growth hormon... | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0050804 modulation of chemical synaptic transmission | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0050867 positive regulation of cell activation | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0051428 peptide hormone receptor binding | IEA GO_REF:0000107 | MODIFY | Summary: JAK2 binds the cytoplasmic box1/box2 region of cytokine and hormone receptors. Reason: Correct but general. The receptors JAK2 binds are cytokine-family receptors (including GHR, EPOR, MPL, beta c, gp130, IL-23R); cytokine receptor binding is the appropriately specific term. Proposed replacements: cytokine receptor binding Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:15899890 Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | TAS Reactome:R-HSA-9027276 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0060333 type II interferon-mediated signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0060333 type II interferon-mediated signaling pathway | TAS Reactome:R-HSA-877300 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0060391 positive regulation of SMAD protein signal transduction | IGI PMID:28334068 The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon G... | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0060396 growth hormone receptor signaling pathway | IDA PMID:10925297 Regulation of neutrophil adhesion by pituitary growth hormon... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | IBA GO_REF:0000033 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | IDA PMID:15690087 SOCS2 negatively regulates growth hormone action in vitro an... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | IEA GO_REF:0000120 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | ISS GO_REF:0000024 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0060399 positive regulation of growth hormone receptor signaling pathway | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: JAK2 as a regulator of JAK-STAT/GH receptor signaling. Reason: JAK2 is the core kinase of these pathways rather than a regulator of them; participation is already captured by the accepted pathway terms. JH2-mediated autoinhibition is intramolecular. Supporting Evidence: PMID:21841788 Here we show that JH2 is a dual-specificity protein kinase that phosphorylates two negative regulatory sites in JAK2: Ser523 and Tyr570. |
| GO:0060399 positive regulation of growth hormone receptor signaling pathway | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: JAK2 as a regulator of JAK-STAT/GH receptor signaling. Reason: JAK2 is the core kinase of these pathways rather than a regulator of them; participation is already captured by the accepted pathway terms. JH2-mediated autoinhibition is intramolecular. Supporting Evidence: PMID:21841788 Here we show that JH2 is a dual-specificity protein kinase that phosphorylates two negative regulatory sites in JAK2: Ser523 and Tyr570. |
| GO:0061180 mammary gland epithelium development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Developmental outcome downstream of JAK2-dependent hormone or cytokine signaling. Reason: JAK2 mediates prolactin, GH and neurotrophic cytokine signaling that influences these developmental and regenerative processes; these are downstream, context-specific outcomes. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0070102 interleukin-6-mediated signaling pathway | TAS Reactome:R-HSA-1059683 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0070120 ciliary neurotrophic factor-mediated signaling pathway | IDA PMID:11294841 Signaling pathways recruited by the cardiotrophin-like cytok... | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0070665 positive regulation of leukocyte proliferation | IDA PMID:18692472 The structure of the GM-CSF receptor complex reveals a disti... | KEEP AS NON CORE | Summary: JAK2-dependent cytokine/growth-factor signaling affects cell proliferation or migration. Reason: Proliferation of hematopoietic and other cells downstream of cytokine receptors depends on JAK2, but the proliferative outcome is downstream of its kinase function. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:0070671 response to interleukin-12 | IDA PMID:7528775 Interleukin 12 (IL-12) induces tyrosine phosphorylation of J... | KEEP AS NON CORE | Summary: JAK2 activation observed upon cytokine stimulation. Reason: JAK2 phosphorylation is observed in response to the cytokine; the specific cytokine receptor JAK-STAT signaling terms capture the core role. Supporting Evidence: PMID:8609418 We show that JAK2 kinase is rapidly phosphorylated and activated in response to IL-13. |
| GO:0070757 interleukin-35-mediated signaling pathway | TAS Reactome:R-HSA-8984722 | ACCEPT | Summary: JAK2 is the receptor-associated tyrosine kinase that transduces signals for this cytokine receptor pathway. Reason: JAK2 executes the kinase step of cytokine receptor signaling via JAK-STAT, phosphorylating the receptor and STATs. Direct evidence in human cells covers EPO, GM-CSF/IL-3/IL-5 (beta c), IL-12/IL-23, gp130-family cytokines (OSM, LIF, CNTF, CLC/CLF), GH and TPO, and knockout mice lack definitive erythropoiesis and IFN-gamma responses. Supporting Evidence: PMID:9657743 We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. PMID:8272873 The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. |
| GO:0097191 extrinsic apoptotic signaling pathway | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: JAK2 implicated in apoptotic signaling from rodent data. Reason: JAK2 influences cell survival through cytokine signaling but is not part of the apoptotic machinery; effects on apoptosis are indirect and context dependent. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0098794 postsynapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Synaptic localization from rodent data. Reason: JAK2 is expressed in neurons and has reported postsynaptic signaling roles; peripheral to its core cytokine function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Synaptic localization from rodent data. Reason: JAK2 is expressed in neurons and has reported postsynaptic signaling roles; peripheral to its core cytokine function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:0120162 positive regulation of cold-induced thermogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Metabolic/endocrine outcome of JAK2 signaling (mouse data). Reason: Adipose and endocrine JAK2 signaling affects thermogenesis and insulin secretion in mice; downstream physiological outcomes. Supporting Evidence: PMID:26515423 JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. |
| GO:0120162 positive regulation of cold-induced thermogenesis | ISS PMID:26515423 JAK2 promotes brown adipose tissue function and is required ... | KEEP AS NON CORE | Summary: Metabolic/endocrine outcome of JAK2 signaling (mouse data). Reason: Adipose and endocrine JAK2 signaling affects thermogenesis and insulin secretion in mice; downstream physiological outcomes. Supporting Evidence: PMID:26515423 JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. |
| GO:0120186 negative regulation of protein localization to chromatin | IDA PMID:19783980 JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from... | KEEP AS NON CORE | Summary: H3Y41 phosphorylation by nuclear JAK2 excludes HP1alpha from chromatin. Reason: Supported by the nuclear H3Y41 study; a secondary nuclear role. Supporting Evidence: PMID:19783980 Phosphorylation of H3Y41 by JAK2 prevents this binding. |
| GO:0140546 defense response to symbiont | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:0160108 animal gross anatomical part developmental process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Developmental outcome downstream of JAK2-dependent hormone or cytokine signaling. Reason: JAK2 mediates prolactin, GH and neurotrophic cytokine signaling that influences these developmental and regenerative processes; these are downstream, context-specific outcomes. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:1900016 negative regulation of cytokine production involved in inflammatory response | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:1900016 negative regulation of cytokine production involved in inflammatory response | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Immune or inflammatory outcome of JAK2-dependent cytokine signaling. Reason: JAK2 mediates IFN-gamma, GM-CSF, IL-12/IL-23 and gp130-family signaling, so it influences cytokine production, microglial and macrophage activation and antiviral defense; these are downstream outcomes. Supporting Evidence: PMID:9590174 The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis. PMID:12023369 IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
| GO:1901731 positive regulation of platelet aggregation | IDA PMID:31145836 Physical proximity and functional cooperation of glycoprotei... | KEEP AS NON CORE | Summary: JAK2 signaling modulates adhesion or platelet activation. Reason: Reported outcomes of GH, gp130/IL-6 and other JAK2-dependent signaling in neutrophils, platelets and other cells; downstream and context-specific. Supporting Evidence: PMID:10925297 Pituitary GH triggered the tyrosine phosphorylation of Janus kinase 2 (Jak2) and STAT3 in neutrophils. |
| GO:1902533 positive regulation of intracellular signal transduction | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2-dependent cytokine/growth-factor signaling affects cell proliferation or migration. Reason: Proliferation of hematopoietic and other cells downstream of cytokine receptors depends on JAK2, but the proliferative outcome is downstream of its kinase function. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:1904037 positive regulation of epithelial cell apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 signaling modulates apoptosis in various cell types. Reason: Survival signaling by cytokines (EPO, GH, leptin, gp130 family) through JAK2-STAT regulates apoptosis indirectly; acceptable as a non-core downstream consequence. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
| GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2-dependent cytokine/growth-factor signaling affects cell proliferation or migration. Reason: Proliferation of hematopoietic and other cells downstream of cytokine receptors depends on JAK2, but the proliferative outcome is downstream of its kinase function. Supporting Evidence: PMID:8007942 JAK2 physically associates with the beta c chain but not with the alpha chain. |
| GO:1905539 regulation of postsynapse to nucleus signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK2 contributes to a signaling pathway or downstream signaling output. Reason: JAK2-dependent receptor signaling engages PI3K/AKT, MAPK and other outputs, and JAK2 has reported roles downstream of additional receptors (PDGF, LPS/TLR, collagen/GPVI, hormones). These are context-specific roles secondary to its cytokine-receptor kinase function. Supporting Evidence: file:human/JAK2/JAK2-uniprot.txt Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins |
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Download this section (compressed HTML)Q: How physiologically significant is nuclear JAK2 and H3Y41 phosphorylation relative to the cytoplasmic receptor-bound pool?
Q: How does the JH2 pseudokinase's weak catalytic activity integrate with its autoinhibitory scaffolding role, and how does V617F disrupt both?
Experiment: Quantify the nuclear versus receptor-bound JAK2 pools in primary human erythroid progenitors using endogenously tagged JAK2 and test H3Y41ph in JAK2-null versus rescued cells.
Type: imaging and genetic rescue
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