KIT (CD117, SCFR, c-Kit) is a single-pass type I transmembrane class III receptor tyrosine kinase and the cell-surface receptor for stem cell factor (SCF, encoded by KITLG). Its extracellular region comprises five immunoglobulin-like domains (D1-D5) that bind SCF and mediate receptor-receptor contacts; a single transmembrane helix connects to a cytoplasmic juxtamembrane autoinhibitory segment and a split (kinase-insert-interrupted) tyrosine-protein kinase domain (EC 2.7.10.1). Binding of dimeric SCF brings two KIT molecules together and drives receptor homodimerization, relieving juxtamembrane autoinhibition and triggering reciprocal trans-autophosphorylation on cytoplasmic tyrosines. The resulting phosphotyrosines both increase catalytic activity and serve as docking sites that recruit SH2/PTB-domain effectors, activating the RAS-RAF-MEK-ERK (MAPK), PI3K-AKT, PLCgamma-PKC, SRC-family kinase and JAK-STAT pathways to promote cell survival, proliferation, adhesion, and migration. KIT acts principally at the plasma membrane. Signaling is terminated by protein tyrosine phosphatases (SHP-1/PTPN6, SHP-2/PTPN11) and by CBL-mediated ubiquitination followed by receptor internalization and degradation. KIT-SCF signaling is essential for hematopoietic stem/progenitor cells, mast cells, melanocytes, germ cells/gametogenesis, and gastrointestinal interstitial cells of Cajal. Loss-of-function variants cause piebaldism, whereas gain-of-function/constitutively activating mutations (e.g. D816V, juxtamembrane in-frame deletions/duplications) drive gastrointestinal stromal tumors, systemic mastocytosis, and subsets of acute myeloid leukemia and germ-cell tumors.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001541 ovarian follicle development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT-SCF signaling supports ovarian follicle development/oogenesis. Reason: Gametogenesis developmental output; non-core. |
| GO:0001541 ovarian follicle development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT-SCF signaling supports ovarian follicle development/oogenesis. Reason: Gametogenesis developmental output; non-core. |
| GO:0001669 acrosomal vesicle | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Sub-acrosomal/acrosomal localization of TR-KIT in spermatozoa (ortholog-supported). Reason: Consistent with TR-KIT localization in the sub-acrosomal region of sperm; an isoform/germ-cell-specific location, non-core relative to the membrane receptor. |
| GO:0002020 protease binding | IEA GO_REF:0000107 | UNDECIDED | Summary: Ortholog-transferred 'protease binding'; cannot verify which protease or the mechanism for human KIT. Reason: This is an IEA transferred from an ortholog with no clear KIT-specific mechanistic basis in the available literature (KIT is a substrate of TACE/ADAM17 shedding, but that does not establish a 'protease binding' molecular function). Insufficient evidence to accept or reject. |
| GO:0002244 hematopoietic progenitor cell differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: KIT-SCF signaling supports hematopoietic progenitor differentiation. Reason: Lineage developmental output; IBA placement sound; non-core. |
| GO:0002327 immature B cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT contributes to early/immature B cell differentiation. Reason: Lineage developmental output (early lymphopoiesis); non-core. |
| GO:0002327 immature B cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT contributes to early/immature B cell differentiation. Reason: Lineage developmental output (early lymphopoiesis); non-core. |
| GO:0002551 mast cell chemotaxis | IDA PMID:20100931 CD72 negatively regulates KIT-mediated responses in human ma... | KEEP AS NON CORE | Summary: SCF-KIT signaling drives mast cell chemotaxis. Reason: A cell-type-specific effector output of KIT signaling in mast cells, downstream of the core receptor activity. Supporting Evidence: PMID:20100931 significantly reducing SCF-induced human mast cell chemotaxis |
| GO:0002720 positive regulation of cytokine production involved in immune response | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: KIT signaling promotes cytokine production in immune responses. Reason: Immune effector output (mast cells); non-core. |
| GO:0002732 positive regulation of dendritic cell cytokine production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT signaling promotes dendritic cell cytokine production. Reason: Immune effector output; ortholog-supported; non-core. |
| GO:0002732 positive regulation of dendritic cell cytokine production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT signaling promotes dendritic cell cytokine production. Reason: Immune effector output; ortholog-supported; non-core. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | MODIFY | Summary: Broad InterPro-derived kinase-domain annotation. Reason: KIT is specifically a transmembrane receptor tyrosine kinase (EC 2.7.10.1); 'protein kinase activity' is too general for a well-characterized tyrosine kinase. Modify to the specific transmembrane receptor protein tyrosine kinase activity. Proposed replacements: transmembrane receptor protein tyrosine kinase activity |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: KIT is a protein tyrosine kinase (EC 2.7.10.1); accurate core molecular function. Reason: KIT autophosphorylates and phosphorylates downstream effectors on tyrosine residues; the term is correct. The more specific transmembrane RTK activity (GO:0004714) is also annotated and captured in core functions. |
| GO:0004713 protein tyrosine kinase activity | TAS PMID:1717985 Mutation of the KIT (mast/stem cell growth factor receptor) ... | ACCEPT | Summary: KIT is a protein tyrosine kinase (EC 2.7.10.1); accurate core molecular function. Reason: KIT autophosphorylates and phosphorylates downstream effectors on tyrosine residues; the term is correct. The more specific transmembrane RTK activity (GO:0004714) is also annotated and captured in core functions. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9669890 | ACCEPT | Summary: KIT is a protein tyrosine kinase (EC 2.7.10.1); accurate core molecular function. Reason: KIT autophosphorylates and phosphorylates downstream effectors on tyrosine residues; the term is correct. The more specific transmembrane RTK activity (GO:0004714) is also annotated and captured in core functions. |
| GO:0004714 transmembrane receptor protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Core molecular function: KIT is a transmembrane receptor tyrosine kinase activated by SCF-induced dimerization. Reason: Directly supported experimentally; SCF binding drives dimerization and kinase activation. IBA reflects a sound phylogenetic placement within the class III RTK clade. |
| GO:0004714 transmembrane receptor protein tyrosine kinase activity | IDA PMID:21640708 Mechanism of activation of human c-KIT kinase by internal ta... | ACCEPT | Summary: Core molecular function: KIT is a transmembrane receptor tyrosine kinase activated by SCF-induced dimerization. Reason: Directly supported experimentally; SCF binding drives dimerization and kinase activation. IBA reflects a sound phylogenetic placement within the class III RTK clade. Supporting Evidence: PMID:21640708 induced constitutive activation of c-KIT kinase in the absence of ligand |
| GO:0004714 transmembrane receptor protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core molecular function: KIT is a transmembrane receptor tyrosine kinase activated by SCF-induced dimerization. Reason: Directly supported experimentally; SCF binding drives dimerization and kinase activation. IBA reflects a sound phylogenetic placement within the class III RTK clade. |
| GO:0005020 stem cell factor receptor activity | IEA GO_REF:0000107 | ACCEPT | Summary: Core molecular function: KIT is the receptor for stem cell factor (SCF/KITLG). Reason: SCF binding to the D1-D3 ectodomain is the defining activity of KIT; well established structurally and biochemically. Supporting Evidence: PMID:17662946 KIT dimerization is driven by SCF binding whose sole role is to bring two KIT molecules together |
| GO:0005515 protein binding | IPI PMID:10377264 Identification of Tyr-703 and Tyr-936 as the primary associa... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:10377264 Identification of Tyr-703 and Tyr-936 as the primary associa... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:10397721 The receptor protein tyrosine phosphatase, PTP-RO, is upregu... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:11018522 The direct association of the multiple PDZ domain containing... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:12878163 Identification of Tyr900 in the kinase domain of c-Kit as a ... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:1382595 Inhibition of SH2 domain/phosphoprotein association by a non... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:17662946 Structural basis for activation of the receptor tyrosine kin... | MODIFY | Summary: Interaction is with the ligand SCF/KITLG; a more informative molecular function is warranted. Reason: This IPI records binding to KITLG (SCF), the KIT ligand. Generic 'protein binding' is uninformative; the specific function is stem cell factor receptor activity. Proposed replacements: stem cell factor receptor activity Supporting Evidence: PMID:17662946 KIT dimerization is driven by SCF binding whose sole role is to bring two KIT molecules together |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:7523381 The ubiquitously expressed Syp phosphatase interacts with c-... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:7523381 The ubiquitously expressed Syp phosphatase interacts with c-... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:7537096 Formation of signal transfer complexes between stem cell and... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:7537096 Formation of signal transfer complexes between stem cell and... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005515 protein binding | IPI PMID:7537096 Formation of signal transfer complexes between stem cell and... | REMOVE | Summary: Generic 'protein binding' conveys no specific molecular function. Reason: The recorded interaction is real (KIT phosphotyrosines recruit SH2/PTB effectors, phosphatases and adapters), but GO:0005515 is uninformative and adds nothing beyond the specific kinase/receptor functions and documented interactors. Removal does not imply the interaction is false; the informative functions (RTK activity, SCF receptor activity, SH2 domain binding) are captured elsewhere. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: ATP binding is required for KIT tyrosine kinase catalysis. Reason: The kinase domain binds ATP as phosphate donor; crystal structures show ADP/ATP-site occupancy. Correct core cofactor-binding function. |
| GO:0005576 extracellular region | IDA PMID:14625290 Tumor necrosis factor-alpha-converting enzyme controls surfa... | KEEP AS NON CORE | Summary: A soluble KIT ectodomain is released by TACE/ADAM17-mediated shedding. Reason: Experimentally, the KIT ectodomain is shed into the extracellular space; this is a real but minor/derived localization, not the core site of receptor function (the plasma membrane). Supporting Evidence: PMID:14625290 release of c-Kit ectodomain |
| GO:0005737 cytoplasm | EXP PMID:20601678 Expression of a truncated form of KIT tyrosine kinase in hum... | KEEP AS NON CORE | Summary: Cytoplasmic localization reflects the truncated intracellular TR-KIT isoform in germ cells/spermatozoa. Reason: TR-KIT (isoform P10721-4) lacks the transmembrane region and is cytoplasmic; the full-length receptor functions at the plasma membrane. Real but isoform-specific/non-core. Supporting Evidence: PMID:20601678 localized both in the equatorial segment and in the sub-acrosomal region |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Cytoplasmic localization reflects the truncated intracellular TR-KIT isoform in germ cells/spermatozoa. Reason: TR-KIT (isoform P10721-4) lacks the transmembrane region and is cytoplasmic; the full-length receptor functions at the plasma membrane. Real but isoform-specific/non-core. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433418 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433423 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433428 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433451 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433454 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433456 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433471 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433488 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433501 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433506 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433508 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433514 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433542 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1470009 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1470010 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1470012 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1472121 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1562640 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1562641 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205231 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205234 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205238 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205244 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205262 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205286 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205289 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205306 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205319 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205321 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-205328 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8864698 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669854 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669855 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669859 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669863 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669868 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669870 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669874 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669878 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669890 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669893 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669898 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669900 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669906 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9669911 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670412 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670413 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670414 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670416 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670417 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670418 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670426 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670428 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670431 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670433 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670436 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9680242 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9680248 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9681375 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9681382 | ACCEPT | Summary: Core cellular location: mature KIT is a plasma-membrane receptor. Reason: KIT is a single-pass type I plasma-membrane receptor; ectodomain external, kinase domain cytoplasmic. Well established. Multiple TAS (Reactome), IBA, IDA and IEA lines concur. |
| GO:0005911 cell-cell junction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog-transferred cell-cell junction localization. Reason: Peripheral, ortholog-derived localization; not a core site of KIT receptor function. Retained as non-core. |
| GO:0006935 chemotaxis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: KIT signaling contributes to chemotaxis (parent term). Reason: Broad migratory output; non-core. |
| GO:0006954 inflammatory response | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT (via mast cells) contributes to inflammatory responses. Reason: Immune output mediated by mast cells; non-core. |
| GO:0006954 inflammatory response | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT (via mast cells) contributes to inflammatory responses. Reason: Immune output mediated by mast cells; non-core. |
| GO:0007165 signal transduction | TAS PMID:9990072 Activating and dominant inactivating c-KIT catalytic domain ... | ACCEPT | Summary: KIT transduces extracellular SCF signals into intracellular responses. Reason: Correct though general; the specific Kit signaling pathway (GO:0038109) is also annotated. Retained as an accurate broad process. |
| GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway | IEA GO_REF:0000002 | ACCEPT | Summary: KIT signaling is a cell-surface RTK signaling pathway (parent of the Kit pathway). Reason: Accurate; KIT is a cell-surface RTK whose activation initiates downstream tyrosine-phosphorylation cascades. |
| GO:0007283 spermatogenesis | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: KIT-SCF signaling is required for spermatogenesis/germ-cell development. Reason: Gametogenesis developmental output; non-core relative to receptor activity. |
| GO:0007283 spermatogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT-SCF signaling is required for spermatogenesis/germ-cell development. Reason: Gametogenesis developmental output; non-core relative to receptor activity. |
| GO:0007283 spermatogenesis | TAS PMID:16129412 Signaling by Kit protein-tyrosine kinase--the stem cell fact... | KEEP AS NON CORE | Summary: KIT-SCF signaling is required for spermatogenesis/germ-cell development. Reason: Gametogenesis developmental output; non-core relative to receptor activity. |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | ACCEPT | Summary: KIT signaling positively regulates cell proliferation. Reason: A core biological output of SCF-KIT signaling across multiple lineages; IBA placement sound; consistent with proliferation driven by activating mutations. |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000107 | ACCEPT | Summary: KIT signaling positively regulates cell proliferation. Reason: A core biological output of SCF-KIT signaling across multiple lineages; IBA placement sound; consistent with proliferation driven by activating mutations. |
| GO:0008354 primordial germ cell migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT-SCF signaling supports primordial germ cell migration. Reason: Developmental migratory output; non-core. |
| GO:0008360 regulation of cell shape | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT signaling influences cell shape. Reason: Cytoskeletal output; ortholog-supported; non-core. |
| GO:0008360 regulation of cell shape | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT signaling influences cell shape. Reason: Cytoskeletal output; ortholog-supported; non-core. |
| GO:0008406 gonad development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: KIT contributes to gonad development. Reason: Developmental output; non-core. |
| GO:0008542 visual learning | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog-transferred role in visual learning (rodent CNS KIT/SCF). Reason: Peripheral CNS role from rodent ortholog; non-core. |
| GO:0008584 male gonad development | IEP PMID:17848411 Developmental changes in human fetal testicular cell numbers... | KEEP AS NON CORE | Summary: KIT is expressed in developing fetal testis (germ cells) consistent with a role in male gonad development. Reason: IEP based on expression during human fetal testis development; a developmental output, non-core relative to receptor kinase activity. |
| GO:0009897 external side of plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: The SCF-binding Ig-like ectodomain faces the external side of the plasma membrane. Reason: Consistent with KIT type I topology; accurate refinement of plasma-membrane localization. |
| GO:0009898 cytoplasmic side of plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: The KIT kinase domain lies on the cytoplasmic side of the plasma membrane. Reason: Consistent with type I topology; the intracellular kinase region signals from the cytoplasmic face. Accurate. |
| GO:0009986 cell surface | IEA GO_REF:0000107 | ACCEPT | Summary: KIT (CD117) is a cell-surface receptor. Reason: Cell-surface expression is the basis of CD117 immunodetection; accurate, consistent with plasma-membrane localization. |
| GO:0016477 cell migration | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: SCF-KIT signaling promotes cell migration. Reason: Migratory output of KIT signaling across lineages; IBA (self in WITH) sound; non-core relative to receptor activity. |
| GO:0016477 cell migration | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: SCF-KIT signaling promotes cell migration. Reason: Migratory output of KIT signaling across lineages; IBA (self in WITH) sound; non-core relative to receptor activity. |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:21640708 Mechanism of activation of human c-KIT kinase by internal ta... | ACCEPT | Summary: SCF is a cytokine; KIT mediates cytokine (SCF)-mediated signaling. Reason: KIT is the receptor for the cytokine SCF and transduces its signal; accurate. Supporting Evidence: PMID:21640708 induced constitutive activation of c-KIT kinase in the absence of ligand |
| GO:0019827 stem cell population maintenance | TAS PMID:21057534 Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as... | KEEP AS NON CORE | Summary: KIT-SCF signaling supports hematopoietic stem cell maintenance. Reason: Stem-cell maintenance output of KIT signaling; non-core relative to receptor activity. |
| GO:0019838 growth factor binding | IBA GO_REF:0000033 | ACCEPT | Summary: KIT binds the growth factor SCF/KITLG. Reason: Ligand (SCF, a growth factor) binding by the ectodomain; IBA placement across class III RTKs is sound. Consistent with stem cell factor receptor activity. |
| GO:0019955 cytokine binding | IDA PMID:21640708 Mechanism of activation of human c-KIT kinase by internal ta... | ACCEPT | Summary: KIT binds its ligand SCF, which is classified as a cytokine. Reason: SCF/KITLG is a cytokine; the receptor binds it directly. Consistent with receptor activity. |
| GO:0019955 cytokine binding | IEA GO_REF:0000120 | ACCEPT | Summary: KIT binds its ligand SCF, which is classified as a cytokine. Reason: SCF/KITLG is a cytokine; the receptor binds it directly. Consistent with receptor activity. |
| GO:0030032 lamellipodium assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT signaling contributes to lamellipodium assembly. Reason: Cytoskeletal/migratory output; ortholog-supported; non-core. |
| GO:0030032 lamellipodium assembly | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT signaling contributes to lamellipodium assembly. Reason: Cytoskeletal/migratory output; ortholog-supported; non-core. |
| GO:0030036 actin cytoskeleton organization | IDA PMID:1721869 Activation of the human c-kit product by ligand-induced dime... | KEEP AS NON CORE | Summary: SCF-activated KIT induces actin cytoskeleton reorganization. Reason: A downstream cytoskeletal output of KIT signaling (circular actin reorganization), non-core relative to the receptor's molecular function. Supporting Evidence: PMID:1721869 induce circular actin reorganization |
| GO:0030097 hemopoiesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: KIT-SCF signaling is essential for hematopoiesis. Reason: Broad developmental output of KIT signaling; non-core relative to receptor activity. |
| GO:0030097 hemopoiesis | TAS PMID:16129412 Signaling by Kit protein-tyrosine kinase--the stem cell fact... | KEEP AS NON CORE | Summary: KIT-SCF signaling is essential for hematopoiesis. Reason: Broad developmental output of KIT signaling; non-core relative to receptor activity. |
| GO:0030183 B cell differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: KIT contributes to B cell differentiation. Reason: Lineage developmental output; IBA placement sound; non-core. |
| GO:0030217 T cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT contributes to T cell differentiation. Reason: Lineage developmental output; non-core. |
| GO:0030217 T cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT contributes to T cell differentiation. Reason: Lineage developmental output; non-core. |
| GO:0030218 erythrocyte differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT supports erythroid differentiation. Reason: Lineage developmental output (KIT cooperates with EPO signaling); non-core. |
| GO:0030218 erythrocyte differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT supports erythroid differentiation. Reason: Lineage developmental output (KIT cooperates with EPO signaling); non-core. |
| GO:0030318 melanocyte differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT is required for melanocyte development (piebaldism when lost). Reason: Lineage developmental output; strongly supported by human piebaldism but non-core relative to receptor kinase activity. |
| GO:0030318 melanocyte differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT is required for melanocyte development (piebaldism when lost). Reason: Lineage developmental output; strongly supported by human piebaldism but non-core relative to receptor kinase activity. |
| GO:0030318 melanocyte differentiation | TAS PMID:21057534 Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as... | KEEP AS NON CORE | Summary: KIT is required for melanocyte development (piebaldism when lost). Reason: Lineage developmental output; strongly supported by human piebaldism but non-core relative to receptor kinase activity. |
| GO:0030335 positive regulation of cell migration | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: KIT signaling positively regulates cell migration. Reason: Migratory output of KIT signaling; non-core. |
| GO:0030335 positive regulation of cell migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT signaling positively regulates cell migration. Reason: Migratory output of KIT signaling; non-core. |
| GO:0031274 positive regulation of pseudopodium assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT signaling contributes to pseudopodium assembly. Reason: Cytoskeletal/migratory output; ortholog-supported; non-core. |
| GO:0032765 positive regulation of mast cell cytokine production | IDA PMID:20100931 CD72 negatively regulates KIT-mediated responses in human ma... | KEEP AS NON CORE | Summary: SCF-KIT signaling promotes mast cell cytokine (e.g. MCP-1/CCL2) production. Reason: Mast-cell-specific effector output downstream of KIT; non-core relative to receptor kinase activity. Supporting Evidence: PMID:20100931 significantly reducing SCF-induced human mast cell chemotaxis |
| GO:0035019 somatic stem cell population maintenance | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT supports somatic stem cell maintenance. Reason: Stem-cell maintenance output; non-core. |
| GO:0035162 embryonic hemopoiesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT contributes to embryonic hematopoiesis. Reason: Developmental hematopoietic output; non-core. |
| GO:0035162 embryonic hemopoiesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT contributes to embryonic hematopoiesis. Reason: Developmental hematopoietic output; non-core. |
| GO:0035855 megakaryocyte development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT contributes to megakaryocyte development. Reason: Lineage developmental output; non-core. |
| GO:0035855 megakaryocyte development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT contributes to megakaryocyte development. Reason: Lineage developmental output; non-core. |
| GO:0038093 Fc receptor signaling pathway | IDA PMID:20100931 CD72 negatively regulates KIT-mediated responses in human ma... | KEEP AS NON CORE | Summary: KIT participates in FcepsilonRI (Fc receptor) signaling crosstalk in mast cells. Reason: SCF-activated KIT synergizes with and enhances IgE/FcepsilonRI-dependent mast cell responses; a cell-type-specific crosstalk role, non-core to the receptor's own kinase activity. Supporting Evidence: PMID:20100931 Unlike the BCR, KIT possesses inherent catalytic activity which is increased upon SCF-induced KIT dimerization |
| GO:0038093 Fc receptor signaling pathway | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: KIT participates in FcepsilonRI (Fc receptor) signaling crosstalk in mast cells. Reason: SCF-activated KIT synergizes with and enhances IgE/FcepsilonRI-dependent mast cell responses; a cell-type-specific crosstalk role, non-core to the receptor's own kinase activity. |
| GO:0038109 Kit signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Core biological process: KIT executes the Kit (SCF) signaling pathway. Reason: This is the pathway KIT initiates upon SCF binding. IBA placement is sound (self P10721 in WITH reflects experimental grounding on KIT itself); IDA and IEA concur. |
| GO:0038109 Kit signaling pathway | IDA PMID:17662946 Structural basis for activation of the receptor tyrosine kin... | ACCEPT | Summary: Core biological process: KIT executes the Kit (SCF) signaling pathway. Reason: This is the pathway KIT initiates upon SCF binding. IBA placement is sound (self P10721 in WITH reflects experimental grounding on KIT itself); IDA and IEA concur. Supporting Evidence: PMID:17662946 KIT dimerization is driven by SCF binding whose sole role is to bring two KIT molecules together |
| GO:0038109 Kit signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: Core biological process: KIT executes the Kit (SCF) signaling pathway. Reason: This is the pathway KIT initiates upon SCF binding. IBA placement is sound (self P10721 in WITH reflects experimental grounding on KIT itself); IDA and IEA concur. |
| GO:0038162 erythropoietin-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT cooperates in erythropoietin-mediated signaling during erythropoiesis. Reason: Ortholog-supported cooperative role in erythroid signaling; peripheral/non-core. |
| GO:0038162 erythropoietin-mediated signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT cooperates in erythropoietin-mediated signaling during erythropoiesis. Reason: Ortholog-supported cooperative role in erythroid signaling; peripheral/non-core. |
| GO:0042127 regulation of cell population proliferation | IEA GO_REF:0000117 | ACCEPT | Summary: KIT regulates cell proliferation (parent term). Reason: Correct though broader than positive regulation; retained as an accurate process annotation. |
| GO:0042127 regulation of cell population proliferation | TAS PMID:16129412 Signaling by Kit protein-tyrosine kinase--the stem cell fact... | ACCEPT | Summary: KIT regulates cell proliferation (parent term). Reason: Correct though broader than positive regulation; retained as an accurate process annotation. |
| GO:0042127 regulation of cell population proliferation | TAS PMID:21057534 Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as... | ACCEPT | Summary: KIT regulates cell proliferation (parent term). Reason: Correct though broader than positive regulation; retained as an accurate process annotation. |
| GO:0042169 SH2 domain binding | IEA GO_REF:0000107 | ACCEPT | Summary: Phosphorylated KIT tyrosines are bound by SH2-domain effector proteins. Reason: Activated KIT phosphotyrosine motifs recruit numerous SH2-domain proteins (GRB2, GRB7, PIK3R1, PLCG1, SHP1/2, SRC-family kinases). The receptor thus enables SH2 domain binding; consistent with UniProt-documented interactions. |
| GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein | IMP PMID:21135090 Mechanisms of STAT protein activation by oncogenic KIT mutan... | ACCEPT | Summary: KIT drives tyrosine phosphorylation of STAT1/3/5. Reason: Experimentally established downstream of KIT (including D816V mutant); KIT can directly phosphorylate STATs and recruits JAK/SFK activity. Supporting Evidence: PMID:21135090 can directly phosphorylate STATs on the activation-specific tyrosine residues in vitro |
| GO:0042803 protein homodimerization activity | IPI PMID:21640708 Mechanism of activation of human c-KIT kinase by internal ta... | ACCEPT | Summary: SCF binding induces KIT homodimerization, the trigger for kinase activation. Reason: Ligand-induced homodimerization is central to KIT activation; the WITH/self (P10721) reflects experimentally shown homodimer formation. Supporting Evidence: PMID:17662946 KIT dimerization is driven by SCF binding whose sole role is to bring two KIT molecules together |
| GO:0043235 signaling receptor complex | IBA GO_REF:0000033 | ACCEPT | Summary: SCF-bound KIT forms a signaling receptor complex (homodimer with two SCF molecules). Reason: Ligand-induced KIT homodimer is the active signaling assembly; part_of a signaling receptor complex is appropriate. IBA placement across RTKs is sound. |
| GO:0043303 mast cell degranulation | IMP PMID:20100931 CD72 negatively regulates KIT-mediated responses in human ma... | KEEP AS NON CORE | Summary: KIT signaling enhances mast cell degranulation (synergy with FcepsilonRI). Reason: Mast-cell effector output; SCF enhances IgE-dependent degranulation. Non-core lineage-specific process. Supporting Evidence: PMID:20100931 Unlike the BCR, KIT possesses inherent catalytic activity which is increased upon SCF-induced KIT dimerization |
| GO:0043410 positive regulation of MAPK cascade | IEA GO_REF:0000117 | ACCEPT | Summary: Activated KIT positively regulates the MAPK (RAS-RAF-ERK) cascade. Reason: A principal downstream output of KIT signaling; experimentally supported and consistent with UniProt FUNCTION. |
| GO:0043410 positive regulation of MAPK cascade | IMP PMID:21640708 Mechanism of activation of human c-KIT kinase by internal ta... | ACCEPT | Summary: Activated KIT positively regulates the MAPK (RAS-RAF-ERK) cascade. Reason: A principal downstream output of KIT signaling; experimentally supported and consistent with UniProt FUNCTION. Supporting Evidence: PMID:21640708 induced constitutive activation of c-KIT kinase in the absence of ligand |
| GO:0043473 pigmentation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT contributes to pigmentation via melanocyte biology. Reason: Developmental/organismal output; non-core relative to the molecular function. |
| GO:0043473 pigmentation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT contributes to pigmentation via melanocyte biology. Reason: Developmental/organismal output; non-core relative to the molecular function. |
| GO:0043586 tongue development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog-transferred role in tongue development. Reason: Peripheral developmental role from ortholog; non-core. |
| GO:0045321 leukocyte activation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: KIT signaling contributes to leukocyte (mast cell) activation. Reason: Immune-cell effector output; non-core. |
| GO:0045747 positive regulation of Notch signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog-transferred role in positive regulation of Notch signaling. Reason: Peripheral crosstalk role transferred from ortholog; non-core. |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | IBA GO_REF:0000033 | ACCEPT | Summary: KIT positively regulates JAK-STAT signaling. Reason: STAT1/3/5 are activated downstream of KIT; a bona fide downstream output. IBA (self in WITH) and IMP concur. |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | IMP PMID:21135090 Mechanisms of STAT protein activation by oncogenic KIT mutan... | ACCEPT | Summary: KIT positively regulates JAK-STAT signaling. Reason: STAT1/3/5 are activated downstream of KIT; a bona fide downstream output. IBA (self in WITH) and IMP concur. Supporting Evidence: PMID:21135090 STAT1, -3, and -5 proteins are activated downstream of the KIT-Asp(816) mutant |
| GO:0046686 response to cadmium ion | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: 'Response to cadmium ion' is a well-known promiscuously over-transferred term. Reason: This IEA (ortholog transfer) has no KIT-specific mechanistic basis and matches a recognized pattern of spurious over-annotation for 'response to cadmium ion'. Likely an over-annotation. |
| GO:0046777 protein autophosphorylation | IDA PMID:21640708 Mechanism of activation of human c-KIT kinase by internal ta... | ACCEPT | Summary: Core process: ligand-induced trans-autophosphorylation of KIT tyrosines. Reason: Reciprocal autophosphorylation is the activating step of KIT and the initiating event of its signaling; directly supported. Supporting Evidence: PMID:21640708 induced constitutive activation of c-KIT kinase in the absence of ligand |
| GO:0048170 positive regulation of long-term neuronal synaptic plasticity | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog-transferred role in long-term synaptic plasticity (rodent hippocampal SCF-KIT). Reason: Peripheral CNS role from rodent ortholog; non-core. |
| GO:0048565 digestive tract development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT is required for interstitial cells of Cajal in the digestive tract. Reason: Developmental output (ICC pacemaker lineage); non-core. |
| GO:0048565 digestive tract development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT is required for interstitial cells of Cajal in the digestive tract. Reason: Developmental output (ICC pacemaker lineage); non-core. |
| GO:0048863 stem cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT contributes to stem cell differentiation. Reason: Developmental output; non-core. |
| GO:0048863 stem cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT contributes to stem cell differentiation. Reason: Developmental output; non-core. |
| GO:0050673 epithelial cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT signaling contributes to epithelial cell proliferation. Reason: Proliferative output; ortholog-supported; non-core. |
| GO:0050793 regulation of developmental process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: KIT regulates developmental processes (broad). Reason: Very general developmental term; the specific developmental outputs are annotated separately. Non-core. |
| GO:0050910 detection of mechanical stimulus involved in sensory perception of sound | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT contributes to auditory function (cochlear melanocyte biology; deafness in W/Sl mutants). Reason: Peripheral developmental/physiological output linked to melanocyte biology; non-core. |
| GO:0050910 detection of mechanical stimulus involved in sensory perception of sound | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT contributes to auditory function (cochlear melanocyte biology; deafness in W/Sl mutants). Reason: Peripheral developmental/physiological output linked to melanocyte biology; non-core. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | TAS PMID:16129412 Signaling by Kit protein-tyrosine kinase--the stem cell fact... | ACCEPT | Summary: KIT activates PI3K-AKT signaling via phosphorylation of PIK3R1. Reason: A principal downstream output of KIT signaling (Y721 recruits the PI3K regulatory subunit); consistent with UniProt FUNCTION and review literature. |
| GO:0060326 cell chemotaxis | IDA PMID:1721869 Activation of the human c-kit product by ligand-induced dime... | KEEP AS NON CORE | Summary: SCF is a chemotactic agent acting through KIT. Reason: SCF-activated KIT drives chemotaxis; a downstream cellular output, non-core relative to receptor kinase activity. Supporting Evidence: PMID:1721869 induce circular actin reorganization |
| GO:0060374 mast cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT-SCF signaling is required for mast cell differentiation. Reason: Lineage developmental output of KIT signaling; non-core relative to the receptor's molecular function. |
| GO:0060374 mast cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT-SCF signaling is required for mast cell differentiation. Reason: Lineage developmental output of KIT signaling; non-core relative to the receptor's molecular function. |
| GO:0060374 mast cell differentiation | TAS PMID:16129412 Signaling by Kit protein-tyrosine kinase--the stem cell fact... | KEEP AS NON CORE | Summary: KIT-SCF signaling is required for mast cell differentiation. Reason: Lineage developmental output of KIT signaling; non-core relative to the receptor's molecular function. |
| GO:0070662 mast cell proliferation | TAS PMID:21057534 Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as... | KEEP AS NON CORE | Summary: KIT-SCF signaling drives mast cell proliferation. Reason: Mast-cell-specific proliferative output (central to mastocytosis); non-core relative to the receptor activity. |
| GO:0097324 melanocyte migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT-SCF signaling supports melanocyte migration. Reason: Lineage-specific migratory output; non-core. |
| GO:0097324 melanocyte migration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT-SCF signaling supports melanocyte migration. Reason: Lineage-specific migratory output; non-core. |
| GO:0097326 melanocyte adhesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT-SCF signaling supports melanocyte adhesion. Reason: Lineage-specific adhesion output; non-core. |
| GO:0097326 melanocyte adhesion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: KIT-SCF signaling supports melanocyte adhesion. Reason: Lineage-specific adhesion output; non-core. |
| GO:0120072 positive regulation of pyloric antrum smooth muscle contraction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT (via ICC pacemaker function) supports pyloric antrum smooth muscle contraction. Reason: Ortholog-supported ICC-mediated physiological output; peripheral/non-core. |
| GO:1904343 positive regulation of colon smooth muscle contraction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT (via ICC) supports colon smooth muscle contraction. Reason: Ortholog-supported ICC-mediated physiological output; peripheral/non-core. |
| GO:1904349 positive regulation of small intestine smooth muscle contraction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: KIT (via ICC) supports small intestine smooth muscle contraction. Reason: Ortholog-supported ICC-mediated physiological output; peripheral/non-core. |
| GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation | IDA PMID:19088079 Induction of microRNA-221 by platelet-derived growth factor ... | KEEP AS NON CORE | Summary: KIT level modulates vascular smooth muscle cell phenotype (downregulated by miR-221 downstream of PDGF). Reason: The cited study foregrounds miR-221/PDGF, with c-Kit as a downregulated target whose loss shifts vSMCs toward a less contractile phenotype; a peripheral, indirect role rather than a core KIT function. Supporting Evidence: PMID:19088079 down-regulation of the targets c-Kit and p27Kip1 |
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