LIPE

UniProt ID: Q05469
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for LIPE

Existing Annotations Review

GO Term Evidence Action Reason
GO:0004771 sterol ester esterase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004806 triacylglycerol lipase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019433 triglyceride catabolic process
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042572 retinol metabolic process
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004771 sterol ester esterase activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004806 triacylglycerol lipase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005811 lipid droplet
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005901 caveola
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006629 lipid metabolic process
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008202 steroid metabolic process
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008203 cholesterol metabolic process
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016042 lipid catabolic process
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016298 lipase activity
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016787 hydrolase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0047372 monoacylglycerol lipase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
IEA
GO_REF:0000116 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050253 retinyl-palmitate esterase activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0120516 diacylglycerol lipase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32296183
Apr 8. A reference map of the human binary protein interactome.
GO:0005829 cytosol
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019433 triglyceride catabolic process
IEA
GO_REF:0000041 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004771 sterol ester esterase activity
IDA
PMID:15716583
Continuous monitoring of cholesterol oleate hydrolysis by ho... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15716583
2005 Feb 16. Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases.
GO:0004771 sterol ester esterase activity
IDA
PMID:8812477
Molecular cloning, genomic organization, and expression of a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8812477
Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.
GO:0004806 triacylglycerol lipase activity
IDA
PMID:15716583
Continuous monitoring of cholesterol oleate hydrolysis by ho... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15716583
2005 Feb 16. Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases.
GO:0004806 triacylglycerol lipase activity
IDA
PMID:15955102
Identification of a novel keratinocyte retinyl ester hydrola... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15955102
Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase.
GO:0016020 membrane
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046340 diacylglycerol catabolic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046485 ether lipid metabolic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0047372 monoacylglycerol lipase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050253 retinyl-palmitate esterase activity
IDA
PMID:15955102
Identification of a novel keratinocyte retinyl ester hydrola... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15955102
Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase.
GO:0120516 diacylglycerol lipase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0120516 diacylglycerol lipase activity
IDA
PMID:19800417
In vitro stereoselective hydrolysis of diacylglycerols by ho... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19800417
In vitro stereoselective hydrolysis of diacylglycerols by hormone-sensitive lipase.
GO:0120516 diacylglycerol lipase activity
IDA
PMID:8812477
Molecular cloning, genomic organization, and expression of a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8812477
Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.
GO:0005811 lipid droplet
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016042 lipid catabolic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17026959
Association and insulin regulated translocation of hormone-s... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17026959
Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.
GO:0006468 protein phosphorylation
TAS
PMID:3420405
Hormone-sensitive lipase: sequence, expression, and chromoso... 		REMOVE
Summary: MISANNOTATION: LIPE (Hormone-sensitive lipase) is a lipase enzyme (EC 3.1.1.79) that hydrolyzes triacylglycerols and cholesteryl esters, NOT a protein kinase. PMID:3420405 explicitly describes LIPE as REGULATED by phosphorylation - "Hormone-sensitive lipase...is acutely controlled through reversible phosphorylation by catecholamines and insulin" and "The activity-controlling phosphorylation site was localized to Ser563". LIPE is the SUBSTRATE of kinases (PKA, AMPK), not an enzyme that performs phosphorylation.
Supporting Evidence:
PMID:3420405
Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000041
Gene Ontology annotation based on UniPathway vocabulary mapping
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000116
Automatic Gene Ontology annotation based on Rhea mapping
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:15716583
Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases.
PMID:15955102
Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase.
PMID:17026959
Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.
PMID:19800417
In vitro stereoselective hydrolysis of diacylglycerols by hormone-sensitive lipase.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:3420405
Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3.
PMID:8812477
Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.

📄 View Raw YAML

 
id: Q05469
gene_symbol: LIPE
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for LIPE'
existing_annotations:
  - term:
      id: GO:0004771
      label: sterol ester esterase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004806
      label: triacylglycerol lipase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019433
      label: triglyceride catabolic process
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042572
      label: retinol metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004771
      label: sterol ester esterase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004806
      label: triacylglycerol lipase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005811
      label: lipid droplet
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005901
      label: caveola
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006629
      label: lipid metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008202
      label: steroid metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008203
      label: cholesterol metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016042
      label: lipid catabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016298
      label: lipase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016787
      label: hydrolase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0047372
      label: monoacylglycerol lipase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0047376
      label: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming 
        activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000116
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050253
      label: retinyl-palmitate esterase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0120516
      label: diacylglycerol lipase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019433
      label: triglyceride catabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000041
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004771
      label: sterol ester esterase activity
    evidence_type: IDA
    original_reference_id: PMID:15716583
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15716583
          supporting_text: 2005 Feb 16. Continuous monitoring of cholesterol 
            oleate hydrolysis by hormone-sensitive lipase and other cholesterol 
            esterases.
  - term:
      id: GO:0004771
      label: sterol ester esterase activity
    evidence_type: IDA
    original_reference_id: PMID:8812477
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8812477
          supporting_text: Molecular cloning, genomic organization, and 
            expression of a testicular isoform of hormone-sensitive lipase.
  - term:
      id: GO:0004806
      label: triacylglycerol lipase activity
    evidence_type: IDA
    original_reference_id: PMID:15716583
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15716583
          supporting_text: 2005 Feb 16. Continuous monitoring of cholesterol 
            oleate hydrolysis by hormone-sensitive lipase and other cholesterol 
            esterases.
  - term:
      id: GO:0004806
      label: triacylglycerol lipase activity
    evidence_type: IDA
    original_reference_id: PMID:15955102
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15955102
          supporting_text: Identification of a novel keratinocyte retinyl ester 
            hydrolase as a transacylase and lipase.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046340
      label: diacylglycerol catabolic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046485
      label: ether lipid metabolic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0047372
      label: monoacylglycerol lipase activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050253
      label: retinyl-palmitate esterase activity
    evidence_type: IDA
    original_reference_id: PMID:15955102
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15955102
          supporting_text: Identification of a novel keratinocyte retinyl ester 
            hydrolase as a transacylase and lipase.
  - term:
      id: GO:0120516
      label: diacylglycerol lipase activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0120516
      label: diacylglycerol lipase activity
    evidence_type: IDA
    original_reference_id: PMID:19800417
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19800417
          supporting_text: In vitro stereoselective hydrolysis of 
            diacylglycerols by hormone-sensitive lipase.
  - term:
      id: GO:0120516
      label: diacylglycerol lipase activity
    evidence_type: IDA
    original_reference_id: PMID:8812477
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8812477
          supporting_text: Molecular cloning, genomic organization, and 
            expression of a testicular isoform of hormone-sensitive lipase.
  - term:
      id: GO:0005811
      label: lipid droplet
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016042
      label: lipid catabolic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17026959
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17026959
          supporting_text: Association and insulin regulated translocation of 
            hormone-sensitive lipase with PTRF.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: TAS
    original_reference_id: PMID:3420405
    review:
      summary: >-
        MISANNOTATION: LIPE (Hormone-sensitive lipase) is a lipase enzyme (EC 3.1.1.79)
        that hydrolyzes triacylglycerols and cholesteryl esters, NOT a protein kinase.
        PMID:3420405 explicitly describes LIPE as REGULATED by phosphorylation - "Hormone-sensitive
        lipase...is acutely controlled through reversible phosphorylation by catecholamines
        and insulin" and "The activity-controlling phosphorylation site was localized
        to
        Ser563". LIPE is the SUBSTRATE of kinases (PKA, AMPK), not an enzyme that
        performs
        phosphorylation.
      action: REMOVE
      supported_by:
        - reference_id: PMID:3420405
          supporting_text: 'Hormone-sensitive lipase: sequence, expression, and chromosomal
            localization to 19 cent-q13.3.'
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000041
    title: Gene Ontology annotation based on UniPathway vocabulary mapping
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000116
    title: Automatic Gene Ontology annotation based on Rhea mapping
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:15716583
    title: Continuous monitoring of cholesterol oleate hydrolysis by 
      hormone-sensitive lipase and other cholesterol esterases.
    findings: []
  - id: PMID:15955102
    title: Identification of a novel keratinocyte retinyl ester hydrolase as a 
      transacylase and lipase.
    findings: []
  - id: PMID:17026959
    title: Association and insulin regulated translocation of hormone-sensitive 
      lipase with PTRF.
    findings: []
  - id: PMID:19800417
    title: In vitro stereoselective hydrolysis of diacylglycerols by 
      hormone-sensitive lipase.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:3420405
    title: 'Hormone-sensitive lipase: sequence, expression, and chromosomal localization
      to 19 cent-q13.3.'
    findings: []
  - id: PMID:8812477
    title: Molecular cloning, genomic organization, and expression of a 
      testicular isoform of hormone-sensitive lipase.
    findings: []