ID   LMA1L_HUMAN             Reviewed;         526 AA.
AC   Q9HAT1; Q6UWN2;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   10-JUN-2026, entry version 166.
DE   RecName: Full=Protein ERGIC-53-like;
DE   AltName: Full=ERGIC53-like protein;
DE   AltName: Full=Lectin mannose-binding 1-like;
DE            Short=LMAN1-like protein;
DE   Flags: Precursor;
GN   Name=LMAN1L; Synonyms=ERGL; ORFNames=UNQ2784/PRO7174;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND ALTERNATIVE
RP   SPLICING.
RX   PubMed=11255007; DOI=10.1016/s0378-1119(01)00347-x;
RA   Yerushalmi N., Keppler-Hafkemeyer A., Vasmatzis G., Liu X.-F., Olsson P.,
RA   Bera T.K., Duray P., Lee B., Pastan I.;
RT   "ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal
RT   and neoplastic prostate and several other tissues.";
RL   Gene 265:55-60(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane {ECO:0000250}; Single-pass type I membrane protein
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9HAT1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9HAT1-2; Sequence=Not described;
CC       Name=3;
CC         IsoId=Q9HAT1-3; Sequence=VSP_013143;
CC   -!- TISSUE SPECIFICITY: Highly expressed in normal and neoplastic prostate.
CC       Also expressed in cardiac atrium, salivary gland, spleen and selective
CC       cells in the CNS. {ECO:0000269|PubMed:11255007}.
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DR   EMBL; AF303398; AAG30902.1; -; mRNA.
DR   EMBL; AY358724; AAQ89086.1; -; mRNA.
DR   CCDS; CCDS10270.1; -. [Q9HAT1-1]
DR   RefSeq; NP_068591.2; NM_021819.3. [Q9HAT1-1]
DR   AlphaFoldDB; Q9HAT1; -.
DR   SMR; Q9HAT1; -.
DR   BioGRID; 122860; 20.
DR   FunCoup; Q9HAT1; 174.
DR   IntAct; Q9HAT1; 8.
DR   STRING; 9606.ENSP00000310431; -.
DR   GlyCosmos; Q9HAT1; 1 site, No reported glycans.
DR   GlyGen; Q9HAT1; 1 site.
DR   iPTMnet; Q9HAT1; -.
DR   PhosphoSitePlus; Q9HAT1; -.
DR   BioMuta; LMAN1L; -.
DR   DMDM; 61252672; -.
DR   MassIVE; Q9HAT1; -.
DR   PaxDb; 9606-ENSP00000310431; -.
DR   PeptideAtlas; Q9HAT1; -.
DR   ProteomicsDB; 81427; -. [Q9HAT1-1]
DR   ProteomicsDB; 81428; -. [Q9HAT1-3]
DR   Antibodypedia; 55435; 96 antibodies from 16 providers.
DR   DNASU; 79748; -.
DR   Ensembl; ENST00000309664.10; ENSP00000310431.5; ENSG00000140506.18. [Q9HAT1-1]
DR   Ensembl; ENST00000379709.7; ENSP00000369031.3; ENSG00000140506.18. [Q9HAT1-3]
DR   GeneID; 79748; -.
DR   KEGG; hsa:79748; -.
DR   MANE-Select; ENST00000309664.10; ENSP00000310431.5; NM_021819.3; NP_068591.2.
DR   UCSC; uc002ayt.2; human. [Q9HAT1-1]
DR   AGR; HGNC:6632; -.
DR   ClinPGx; PA30400; -.
DR   CTD; 79748; -.
DR   DisGeNET; 79748; -.
DR   GeneCards; LMAN1L; -.
DR   HGNC; HGNC:6632; LMAN1L.
DR   HPA; ENSG00000140506; Group enriched (brain, heart muscle, lymphoid tissue, prostate, salivary gland).
DR   MalaCards; LMAN1L; -.
DR   MIM; 609548; gene.
DR   OpenTargets; ENSG00000140506; -.
DR   VEuPathDB; HostDB:ENSG00000140506; -.
DR   eggNOG; KOG3838; Eukaryota.
DR   GeneTree; ENSGT00940000161890; -.
DR   HOGENOM; CLU_041093_4_1_1; -.
DR   InParanoid; Q9HAT1; -.
DR   OMA; IRPEGGW; -.
DR   OrthoDB; 10265193at2759; -.
DR   PAN-GO; Q9HAT1; 6 GO annotations based on evolutionary models.
DR   PhylomeDB; Q9HAT1; -.
DR   PathwayCommons; Q9HAT1; -.
DR   Reactome; R-HSA-204005; COPII-mediated vesicle transport.
DR   Reactome; R-HSA-5694530; Cargo concentration in the ER.
DR   SignaLink; Q9HAT1; -.
DR   Agora; ENSG00000140506; -.
DR   BioGRID-ORCS; 79748; 12 hits in 1136 CRISPR screens.
DR   ChiTaRS; LMAN1L; human.
DR   GenomeRNAi; 79748; -.
DR   Pharos; Q9HAT1; Tbio.
DR   PRO; PR:Q9HAT1; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q9HAT1; protein.
DR   Bgee; ENSG00000140506; Expressed in right atrium auricular region and 77 other cell types or tissues.
DR   ExpressionAtlas; Q9HAT1; baseline and differential.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031012; C:extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005537; F:D-mannose binding; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   FunFam; 2.60.120.200:FF:000028; Blast:Protein ERGIC-53; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR051136; Intracellular_Lectin-GPT.
DR   InterPro; IPR005052; Lectin_leg.
DR   PANTHER; PTHR12223:SF31; PROTEIN ERGIC-53-LIKE; 1.
DR   PANTHER; PTHR12223; VESICULAR MANNOSE-BINDING LECTIN; 1.
DR   Pfam; PF03388; Lectin_leg-like; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS51328; L_LECTIN_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Disulfide bond; Glycoprotein; Lectin; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..526
FT                   /note="Protein ERGIC-53-like"
FT                   /id="PRO_0000017663"
FT   TOPO_DOM        26..462
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        484..526
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          31..252
FT                   /note="L-type lectin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00658"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        176..215
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00658"
FT   VAR_SEQ         240..258
FT                   /note="DDHDVLSFLTFSLSEPSPE -> GEDPTGQ (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_013143"
FT   VARIANT         105
FT                   /note="R -> Q (in dbSNP:rs3803568)"
FT                   /id="VAR_049771"
FT   VARIANT         517
FT                   /note="R -> S (in dbSNP:rs1060480)"
FT                   /id="VAR_049772"
FT   CONFLICT        108
FT                   /note="Q -> H (in Ref. 1; AAG30902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        186
FT                   /note="P -> S (in Ref. 2; AAQ89086)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   526 AA;  57129 MW;  B36B81827D219F9E CRC64;
     MPAVSGPGPL FCLLLLLLDP HSPETGCPPL RRFEYKLSFK GPRLALPGAG IPFWSHHGDA
     ILGLEEVRLT PSMRNRSGAV WSRASVPFSA WEVEVQMRVT GLGRRGAQGM AVWYTRGRGH
     VGSVLGGLAS WDGIGIFFDS PAEDTQDSPA IRVLASDGHI PSEQPGDGAS QGLGSCHWDF
     RNRPHPFRAR ITYWGQRLRM SLNSGLTPSD PGEFCVDVGP LLLVPGGFFG VSAATGTLAD
     DHDVLSFLTF SLSEPSPEVP PQPFLEMQQL RLARQLEGLW ARLGLGTRED VTPKSDSEAQ
     GEGERLFDLE ETLGRHRRIL QALRGLSKQL AQAERQWKKQ LGPPGQARPD GGWALDASCQ
     IPSTPGRGGH LSMSLNKDSA KVGALLHGQW TLLQALQEMR DAAVRMAAEA QVSYLPVGIE
     HHFLELDHIL GLLQEELRGP AKAAAKAPRP PGQPPRASSC LQPGIFLFYL LIQTVGFFGY
     VHFRQELNKS LQECLSTGSL PLGPAPHTPR ALGILRRQPL PASMPA
//