| Category | Item | Details | Source/URL |
|---|---|---|---|
| Verified identifier | Gene symbol | **LRCOL1**; approved name: **leucine rich colipase like 1**; human target corresponds to **ENSG00000204583** in Open Targets, matching the requested human gene identity (pqac-00000000, pqac-00000001) | Open Targets target record: https://platform.opentargets.org/target/ENSG00000204583 |
| Verified identifier | UniProt accession | **A6NCL2**; protein described in the prompt as the human UniProt entry for LRCOL1. This identifier is consistent with the requested target, but no separate citeable UniProt context ID was retrieved in-tool, so this row reflects verified conversation context plus Open Targets gene match (pqac-00000001) | UniProt entry URL: https://www.uniprot.org/uniprotkb/A6NCL2/entry |
| Protein annotation | Recommended protein name | **Leucine-rich colipase-like protein 1**; annotated as **precursor** in the prompt. The name is concordant with Open Targets approved target name and the user-provided UniProt description (pqac-00000001) | UniProt entry URL: https://www.uniprot.org/uniprotkb/A6NCL2/entry |
| Domain/family annotation | Domain architecture | User-provided UniProt/domain context indicates **Colipase** domain annotation (**InterPro: IPR001981**) and **Colipase-like** family/domain (**Pfam: PF15083**). Retrieved literature on remote homology notes PF15083 matches colipases, supporting colipase-like assignment at the family level, but not LRCOL1-specific function (pqac-00000001) | InterPro: https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001981 ; Pfam: https://pfam.xfam.org/family/PF15083 |
| Disease-association evidence | Hepatocellular carcinoma | Open Targets overall association score **0.05168**. Evidence includes **RNA expression** from Expression Atlas study **E-GEOD-33294** comparing **liver tumor vs adjacent non-tumor tissue**; PMID **23766440**; confidence noted as **low** (pqac-00000000, pqac-00000002) | Open Targets disease view: https://platform.opentargets.org/disease/EFO_0000182/associations |
| Disease-association evidence | Atrial fibrillation | Open Targets overall association score **0.18443**. Supporting evidence list includes **genetic association** from **GWAS credible sets**; PMID **40645996** appears in the retrieved evidence summary (pqac-00000000, pqac-00000002) | Open Targets disease view: https://platform.opentargets.org/disease/EFO_0000275/associations |
| Disease-association evidence | Brain aneurysm | Open Targets overall association score **0.14535**. Supporting evidence list includes **genetic association** from **GWAS credible sets**; PMID **40645996** in retrieved evidence summary (pqac-00000000, pqac-00000002) | Open Targets disease view: https://platform.opentargets.org/disease/EFO_0003870/associations |
| Disease-association evidence | Neurodegenerative disease | Open Targets overall association score **0.27186**. Supporting evidence includes **affected pathway / functional evidence** from CRISPRi screen **Glutamatergic Neuron-No Antioxidants-Survival-CRISPRi**; PMID **34031600** (pqac-00000000, pqac-00000002) | Open Targets disease view: https://platform.opentargets.org/disease/EFO_0005772/associations |
| Disease-association evidence | COVID-19 | Open Targets overall association score **0.02442**. Supporting evidence list includes **genetic association** from **GWAS credible sets**; PMID **40645996** in retrieved evidence summary (pqac-00000000, pqac-00000002) | Open Targets disease view: https://platform.opentargets.org/disease/MONDO_0100096/associations |
| Evidence inventory | Number and type of retrieved Open Targets evidence items | Retrieved Open Targets summary lists **3 evidence items** tied to LRCOL1: (1) Expression Atlas RNA expression (**PMID 23766440**; study **E-GEOD-33294**), (2) CRISPRi functional/affected-pathway evidence (**PMID 34031600**; study **Glutamatergic Neuron-No Antioxidants-Survival-CRISPRi**), and (3) GWAS credible-set genetic association (**PMID 40645996**) (pqac-00000001, pqac-00000002) | Open Targets target page: https://platform.opentargets.org/target/ENSG00000204583 |
| Limitation note | Sparse LRCOL1-specific literature | Tool searches found **no direct primary papers focused specifically on human LRCOL1/A6NCL2 molecular function**. Available evidence is mostly indirect, high-throughput, or database-integrated rather than targeted biochemical characterization (pqac-00000001, pqac-00000002) | Open Targets target page: https://platform.opentargets.org/target/ENSG00000204583 |
| Limitation note | Function/localization uncertainty | Retrieved citeable evidence **does not directly establish substrate, catalytic activity, pathway membership, or subcellular/extracellular localization** for human LRCOL1. Colipase-like/domain-based inference is plausible but remains unvalidated by LRCOL1-specific functional experiments in the retrieved sources (pqac-00000001, pqac-00000002) | Open Targets target page: https://platform.opentargets.org/target/ENSG00000204583 |
| Limitation note | Caution on disease links | Open Targets scores are **small to modest** and derive from heterogeneous evidence types; they should be interpreted as **hypothesis-generating associations**, not proof that LRCOL1 is causal or clinically actionable in these diseases (pqac-00000000, pqac-00000002) | Open Targets documentation hub: https://platform-docs.opentargets.org/ |


*Table: This table verifies the requested human LRCOL1 target identity and summarizes the currently retrievable evidence landscape. It is useful because it separates firm identifier/domain facts from much weaker, mostly indirect disease-association evidence and highlights the major evidence gaps.*