LRP1

UniProt ID: Q07954
Organism: Homo sapiens
Review Status: COMPLETE
πŸ“ Provide Detailed Feedback

Gene Description

LRP1 encodes low-density lipoprotein receptor-related protein 1, a large LDL receptor-family type I membrane receptor that is proteolytically processed into extracellular ligand-binding and membrane/cytoplasmic subunits. LRP1 acts as a multifunctional endocytic, cargo, scavenger, apolipoprotein/lipoprotein, and alpha-2-macroglobulin receptor, concentrating ligands at the plasma membrane and clathrin-coated pits for receptor-mediated internalization, endosomal trafficking, lysosomal clearance, phagocytosis, and lipid transport. In Alzheimer-relevant biology, LRP1 participates in amyloid-beta binding, clearance, and transcytosis across vascular and cellular barriers, and UniProt also describes it as a tau/MAPT receptor controlling tau endocytosis and spread.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005886 plasma membrane
IBA
GO_REF:0000033 		ACCEPT
Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005886 (plasma membrane), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006898 receptor-mediated endocytosis
IBA
GO_REF:0000033 		ACCEPT
Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006898 (receptor-mediated endocytosis), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006909 phagocytosis
IBA
GO_REF:0000033 		ACCEPT
Summary: phagocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006909 (phagocytosis), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0034185 apolipoprotein binding
IBA
GO_REF:0000033 		ACCEPT
Summary: apolipoprotein binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0034185 (apolipoprotein binding), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0038024 cargo receptor activity
IBA
GO_REF:0000033 		ACCEPT
Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0038024 (cargo receptor activity), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150093 amyloid-beta clearance by transcytosis
IBA
GO_REF:0000033 		ACCEPT
Summary: amyloid-beta clearance by transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150093 (amyloid-beta clearance by transcytosis), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150094 amyloid-beta clearance by cellular catabolic process
IBA
GO_REF:0000033 		ACCEPT
Summary: amyloid-beta clearance by cellular catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0001523 retinoid metabolic process
IEA
GO_REF:0000117 		KEEP AS NON CORE
Summary: retinoid metabolic process is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0001523 (retinoid metabolic process), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005041 low-density lipoprotein particle receptor activity
IEA
GO_REF:0000117 		ACCEPT
Summary: low-density lipoprotein particle receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005041 (low-density lipoprotein particle receptor activity), the IEA annotation with qualifier enables from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005509 calcium ion binding
IEA
GO_REF:0000002 		ACCEPT
Summary: calcium ion binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005509 (calcium ion binding), the IEA annotation with qualifier enables from GO_REF:0000002 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005634 nucleus
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: nucleus is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005634 (nucleus), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005737 (cytoplasm), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005769 early endosome
IEA
GO_REF:0000117 		ACCEPT
Summary: early endosome is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005769 (early endosome), the IEA annotation with qualifier located_in from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005815 microtubule organizing center
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: microtubule organizing center is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005815 (microtubule organizing center), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005886 plasma membrane
IEA
GO_REF:0000120 		ACCEPT
Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in from GO_REF:0000120 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006898 receptor-mediated endocytosis
IEA
GO_REF:0000117 		ACCEPT
Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006898 (receptor-mediated endocytosis), the IEA annotation with qualifier involved_in from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0016020 membrane
IEA
GO_REF:0000044 		ACCEPT
Summary: membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0016020 (membrane), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030100 regulation of endocytosis
IEA
GO_REF:0000117 		KEEP AS NON CORE
Summary: regulation of endocytosis is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0030100 (regulation of endocytosis), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032050 clathrin heavy chain binding
IEA
GO_REF:0000117 		ACCEPT
Summary: clathrin heavy chain binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0032050 (clathrin heavy chain binding), the IEA annotation with qualifier enables from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0044877 protein-containing complex binding
IEA
GO_REF:0000117 		MARK AS OVER ANNOTATED
Summary: protein-containing complex binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0044877 (protein-containing complex binding), the IEA annotation with qualifier enables from GO_REF:0000117 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0046718 symbiont entry into host cell
IEA
GO_REF:0000108 		KEEP AS NON CORE
Summary: symbiont entry into host cell is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0046718 (symbiont entry into host cell), the IEA annotation with qualifier involved_in from GO_REF:0000108 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0051050 positive regulation of transport
IEA
GO_REF:0000117 		ACCEPT
Summary: positive regulation of transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0051050 (positive regulation of transport), the IEA annotation with qualifier involved_in from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0051246 regulation of protein metabolic process
IEA
GO_REF:0000117 		KEEP AS NON CORE
Summary: regulation of protein metabolic process is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0051246 (regulation of protein metabolic process), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding
IPI
PMID:15182176
Two apolipoprotein E mimetic peptides, ApoE(130-149) and Apo... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15182176 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:17326667
Apolipoprotein A-V interaction with members of the low densi... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17326667 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:17360663
HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS compl... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17360663 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:20030366
Decoding of lipoprotein-receptor interactions: properties of... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20030366 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:20472562
Low density lipoprotein receptor-related protein-1 (LRP1) re... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20472562 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:21054788
CD91 interacts with mannan-binding lectin (MBL) through the ... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21054788 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:21968187
Phosphorylation of LRP1 regulates the interaction with Fe65. 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21968187 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:24284412
Amyloid beta a4 precursor protein-binding family B member 1 ... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24284412 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:28514442
Architecture of the human interactome defines protein commun... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28514442 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:29547901
Molecular partners of hNOT/ALG3, the human counterpart of th... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:29547901 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:33961781 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0002673 regulation of acute inflammatory response
IDA
PMID:31326693
The dynamic uptake and release of SOD3 from intracellular st... 		KEEP AS NON CORE
Summary: regulation of acute inflammatory response is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0002673 (regulation of acute inflammatory response), the IDA annotation with qualifier involved_in from PMID:31326693 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0038024 cargo receptor activity
IDA
PMID:31326693
The dynamic uptake and release of SOD3 from intracellular st... 		ACCEPT
Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0038024 (cargo receptor activity), the IDA annotation with qualifier enables from PMID:31326693 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0001523 retinoid metabolic process
TAS
Reactome:R-HSA-975634 		KEEP AS NON CORE
Summary: retinoid metabolic process is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0001523 (retinoid metabolic process), the TAS annotation with qualifier involved_in from Reactome:R-HSA-975634 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005730 nucleolus
IDA
GO_REF:0000052 		KEEP AS NON CORE
Summary: nucleolus is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005730 (nucleolus), the IDA annotation with qualifier located_in from GO_REF:0000052 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005829 cytosol
IDA
GO_REF:0000052 		KEEP AS NON CORE
Summary: cytosol is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005829 (cytosol), the IDA annotation with qualifier located_in from GO_REF:0000052 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005886 plasma membrane
IDA
GO_REF:0000052 		ACCEPT
Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from GO_REF:0000052 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0001618 virus receptor activity
IMP
PMID:41162706
Multiple LDLRΒ family members act as entry receptors for yell... 		KEEP AS NON CORE
Summary: virus receptor activity is retained as a non-core molecular-function annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0001618 (virus receptor activity), the IMP annotation with qualifier enables from PMID:41162706 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005634 nucleus
EXP
PMID:12888553
The intracellular domain of the low density lipoprotein rece... 		KEEP AS NON CORE
Summary: nucleus is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005634 (nucleus), the EXP annotation with qualifier located_in from PMID:12888553 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005737 cytoplasm
EXP
PMID:12888553
The intracellular domain of the low density lipoprotein rece... 		KEEP AS NON CORE
Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:12888553 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0150051 postsynaptic Golgi apparatus
ISS
GO_REF:0000024 		KEEP AS NON CORE
Summary: postsynaptic Golgi apparatus is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150051 (postsynaptic Golgi apparatus), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1903064 positive regulation of reverse cholesterol transport
ISS
GO_REF:0000024 		ACCEPT
Summary: positive regulation of reverse cholesterol transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:1903064 (positive regulation of reverse cholesterol transport), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006898 receptor-mediated endocytosis
IMP
PMID:26781079
Clearance of matrix metalloproteinase-9 is dependent on low-... 		ACCEPT
Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier involved_in from PMID:26781079 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1903053 regulation of extracellular matrix organization
IMP
PMID:26781079
Clearance of matrix metalloproteinase-9 is dependent on low-... 		KEEP AS NON CORE
Summary: regulation of extracellular matrix organization is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:1903053 (regulation of extracellular matrix organization), the IMP annotation with qualifier acts_upstream_of from PMID:26781079 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0060392 negative regulation of SMAD protein signal transduction
ISS
PMID:31023188
LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial ... 		KEEP AS NON CORE
Summary: negative regulation of SMAD protein signal transduction is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0060392 (negative regulation of SMAD protein signal transduction), the ISS annotation with qualifier involved_in from PMID:31023188 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0007167 enzyme-linked receptor protein signaling pathway
ISS
PMID:31023188
LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial ... 		KEEP AS NON CORE
Summary: enzyme-linked receptor protein signaling pathway is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0007167 (enzyme-linked receptor protein signaling pathway), the ISS annotation with qualifier involved_in from PMID:31023188 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010629 negative regulation of gene expression
ISS
PMID:31023188
LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial ... 		KEEP AS NON CORE
Summary: negative regulation of gene expression is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0010629 (negative regulation of gene expression), the ISS annotation with qualifier involved_in from PMID:31023188 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005041 low-density lipoprotein particle receptor activity
TAS
Reactome:R-HSA-2404131 		ACCEPT
Summary: low-density lipoprotein particle receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005041 (low-density lipoprotein particle receptor activity), the TAS annotation with qualifier enables from Reactome:R-HSA-2404131 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006629 lipid metabolic process
TAS
PMID:21289173
Heparan sulphate proteoglycan and the low-density lipoprotei... 		ACCEPT
Summary: lipid metabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006629 (lipid metabolic process), the TAS annotation with qualifier involved_in from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0043395 heparan sulfate proteoglycan binding
TAS
PMID:21289173
Heparan sulphate proteoglycan and the low-density lipoprotei... 		ACCEPT
Summary: heparan sulfate proteoglycan binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0043395 (heparan sulfate proteoglycan binding), the TAS annotation with qualifier enables from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150104 transport across blood-brain barrier
NAS
PMID:30280653
Blood-Brain Barrier: From Physiology to Disease and Back. 		ACCEPT
Summary: transport across blood-brain barrier is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150104 (transport across blood-brain barrier), the NAS annotation with qualifier involved_in from PMID:30280653 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150104 transport across blood-brain barrier
NAS
PMID:26590417
Establishment and Dysfunction of the Blood-Brain Barrier. 		ACCEPT
Summary: transport across blood-brain barrier is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150104 (transport across blood-brain barrier), the NAS annotation with qualifier involved_in from PMID:26590417 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding
IPI
PMID:26005850
Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26005850 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0032050 clathrin heavy chain binding
IPI
PMID:26005850
Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... 		ACCEPT
Summary: clathrin heavy chain binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0032050 (clathrin heavy chain binding), the IPI annotation with qualifier enables from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150093 amyloid-beta clearance by transcytosis
ISS
GO_REF:0000024 		ACCEPT
Summary: amyloid-beta clearance by transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150093 (amyloid-beta clearance by transcytosis), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150104 transport across blood-brain barrier
ISS
GO_REF:0000024 		ACCEPT
Summary: transport across blood-brain barrier is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150104 (transport across blood-brain barrier), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1900223 positive regulation of amyloid-beta clearance
ISS
GO_REF:0000024 		ACCEPT
Summary: positive regulation of amyloid-beta clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:1900223 (positive regulation of amyloid-beta clearance), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1904300 positive regulation of transcytosis
ISS
GO_REF:0000024 		ACCEPT
Summary: positive regulation of transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:1904300 (positive regulation of transcytosis), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0038024 cargo receptor activity
NAS
PMID:3266596
Surface location and high affinity for calcium of a 500-kd l... 		ACCEPT
Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0038024 (cargo receptor activity), the NAS annotation with qualifier enables from PMID:3266596 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding
IPI
PMID:10772929
LDL receptor-related protein as a component of the midkine r... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:10772929 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0007041 lysosomal transport
ISS
GO_REF:0000024 		ACCEPT
Summary: lysosomal transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0007041 (lysosomal transport), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0001540 amyloid-beta binding
IC
GO_REF:0000111 		ACCEPT
Summary: amyloid-beta binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0001540 (amyloid-beta binding), the IC annotation with qualifier enables from GO_REF:0000111 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0002265 astrocyte activation involved in immune response
ISS
GO_REF:0000024 		KEEP AS NON CORE
Summary: astrocyte activation involved in immune response is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0002265 (astrocyte activation involved in immune response), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0006898 receptor-mediated endocytosis
ISS
GO_REF:0000024 		ACCEPT
Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006898 (receptor-mediated endocytosis), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006898 receptor-mediated endocytosis
IMP
PMID:23152628
LRP1 in brain vascular smooth muscle cells mediates local cl... 		ACCEPT
Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006898 receptor-mediated endocytosis
IMP
PMID:24305823
Neuronal clearance of amyloid-Ξ² by endocytic receptor LRP1. 		ACCEPT
Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier involved_in from PMID:24305823 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006898 receptor-mediated endocytosis
IMP
PMID:26005850
Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... 		ACCEPT
Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier involved_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006909 phagocytosis
IMP
PMID:23152628
LRP1 in brain vascular smooth muscle cells mediates local cl... 		ACCEPT
Summary: phagocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006909 (phagocytosis), the IMP annotation with qualifier involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0038024 cargo receptor activity
ISS
GO_REF:0000024 		ACCEPT
Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0038024 (cargo receptor activity), the ISS annotation with qualifier enables from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0038024 cargo receptor activity
IMP
PMID:23152628
LRP1 in brain vascular smooth muscle cells mediates local cl... 		ACCEPT
Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0038024 (cargo receptor activity), the IMP annotation with qualifier enables from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0038024 cargo receptor activity
IMP
PMID:24305823
Neuronal clearance of amyloid-Ξ² by endocytic receptor LRP1. 		ACCEPT
Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0038024 (cargo receptor activity), the IMP annotation with qualifier enables from PMID:24305823 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150093 amyloid-beta clearance by transcytosis
IGI
PMID:26005850
Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... 		ACCEPT
Summary: amyloid-beta clearance by transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150093 (amyloid-beta clearance by transcytosis), the IGI annotation with qualifier involved_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150094 amyloid-beta clearance by cellular catabolic process
ISS
GO_REF:0000024 		ACCEPT
Summary: amyloid-beta clearance by cellular catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150094 amyloid-beta clearance by cellular catabolic process
IMP
PMID:23152628
LRP1 in brain vascular smooth muscle cells mediates local cl... 		ACCEPT
Summary: amyloid-beta clearance by cellular catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IMP annotation with qualifier involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0150094 amyloid-beta clearance by cellular catabolic process
IMP
PMID:24305823
Neuronal clearance of amyloid-Ξ² by endocytic receptor LRP1. 		ACCEPT
Summary: amyloid-beta clearance by cellular catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IMP annotation with qualifier involved_in from PMID:24305823 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1904646 cellular response to amyloid-beta
ISS
GO_REF:0000024 		KEEP AS NON CORE
Summary: cellular response to amyloid-beta is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:1904646 (cellular response to amyloid-beta), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1905167 positive regulation of lysosomal protein catabolic process
IMP
PMID:23152628
LRP1 in brain vascular smooth muscle cells mediates local cl... 		ACCEPT
Summary: positive regulation of lysosomal protein catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:1905167 (positive regulation of lysosomal protein catabolic process), the IMP annotation with qualifier involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1903078 positive regulation of protein localization to plasma membrane
IGI
PMID:23386614
Prion protein-mediated toxicity of amyloid-Ξ² oligomers requi... 		KEEP AS NON CORE
Summary: positive regulation of protein localization to plasma membrane is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:1903078 (positive regulation of protein localization to plasma membrane), the IGI annotation with qualifier involved_in from PMID:23386614 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0045807 positive regulation of endocytosis
IGI
PMID:23386614
Prion protein-mediated toxicity of amyloid-Ξ² oligomers requi... 		ACCEPT
Summary: positive regulation of endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0045807 (positive regulation of endocytosis), the IGI annotation with qualifier involved_in from PMID:23386614 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006909 phagocytosis
NAS
PMID:20199584
Complement receptor 3 (CD11b/CD18) is implicated in the elim... 		ACCEPT
Summary: phagocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0006909 (phagocytosis), the NAS annotation with qualifier involved_in from PMID:20199584 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0097242 amyloid-beta clearance
NAS
PMID:20199584
Complement receptor 3 (CD11b/CD18) is implicated in the elim... 		ACCEPT
Summary: amyloid-beta clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0097242 (amyloid-beta clearance), the NAS annotation with qualifier involved_in from PMID:20199584 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1900223 positive regulation of amyloid-beta clearance
TAS
PMID:22383525
Low-density lipoprotein receptor represents an apolipoprotei... 		ACCEPT
Summary: positive regulation of amyloid-beta clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:1900223 (positive regulation of amyloid-beta clearance), the TAS annotation with qualifier involved_in from PMID:22383525 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005041 low-density lipoprotein particle receptor activity
TAS
PMID:20005821
Overexpression of low-density lipoprotein receptor in the br... 		ACCEPT
Summary: low-density lipoprotein particle receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005041 (low-density lipoprotein particle receptor activity), the TAS annotation with qualifier enables from PMID:20005821 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005044 scavenger receptor activity
TAS
PMID:11240025
Scavenger receptor class B type I (SR-BI) mediates adhesion ... 		ACCEPT
Summary: scavenger receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005044 (scavenger receptor activity), the TAS annotation with qualifier enables from PMID:11240025 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005769 early endosome
IDA
PMID:26005850
Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... 		ACCEPT
Summary: early endosome is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005769 (early endosome), the IDA annotation with qualifier located_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0016323 basolateral plasma membrane
IDA
PMID:26005850
Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... 		ACCEPT
Summary: basolateral plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0016323 (basolateral plasma membrane), the IDA annotation with qualifier located_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0016964 alpha-2 macroglobulin receptor activity
TAS
PMID:21289173
Heparan sulphate proteoglycan and the low-density lipoprotei... 		ACCEPT
Summary: alpha-2 macroglobulin receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0016964 (alpha-2 macroglobulin receptor activity), the TAS annotation with qualifier enables from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030226 apolipoprotein receptor activity
TAS
PMID:21289173
Heparan sulphate proteoglycan and the low-density lipoprotei... 		ACCEPT
Summary: apolipoprotein receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0030226 (apolipoprotein receptor activity), the TAS annotation with qualifier enables from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0098797 plasma membrane protein complex
TAS
PMID:21289173
Heparan sulphate proteoglycan and the low-density lipoprotei... 		ACCEPT
Summary: plasma membrane protein complex is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0098797 (plasma membrane protein complex), the TAS annotation with qualifier part_of from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0016964 alpha-2 macroglobulin receptor activity
IMP
PMID:26142438
Whole exome sequencing identifies LRP1 as a pathogenic gene ... 		ACCEPT
Summary: alpha-2 macroglobulin receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0016964 (alpha-2 macroglobulin receptor activity), the IMP annotation with qualifier enables from PMID:26142438 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0031623 receptor internalization
TAS
PMID:22293988
Cellular prion protein participates in amyloid-Ξ² transcytosi... 		ACCEPT
Summary: receptor internalization is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0031623 (receptor internalization), the TAS annotation with qualifier involved_in from PMID:22293988 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0045056 transcytosis
TAS
PMID:22293988
Cellular prion protein participates in amyloid-Ξ² transcytosi... 		ACCEPT
Summary: transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0045056 (transcytosis), the TAS annotation with qualifier involved_in from PMID:22293988 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0016020 membrane
NAS
PMID:23386614
Prion protein-mediated toxicity of amyloid-Ξ² oligomers requi... 		ACCEPT
Summary: membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0016020 (membrane), the NAS annotation with qualifier located_in from PMID:23386614 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005886 plasma membrane
TAS
PMID:14645246
The low density lipoprotein receptor-related protein LRP is ... 		ACCEPT
Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from PMID:14645246 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0010715 regulation of extracellular matrix disassembly
TAS
PMID:14645246
The low density lipoprotein receptor-related protein LRP is ... 		KEEP AS NON CORE
Summary: regulation of extracellular matrix disassembly is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0010715 (regulation of extracellular matrix disassembly), the TAS annotation with qualifier involved_in from PMID:14645246 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding
IPI
PMID:8626514
Plasminogen activator inhibitor-1 and vitronectin promote th... 		MARK AS OVER ANNOTATED
Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:8626514 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005925 focal adhesion
HDA
PMID:21423176
Analysis of the myosin-II-responsive focal adhesion proteome... 		KEEP AS NON CORE
Summary: focal adhesion is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005925 (focal adhesion), the HDA annotation with qualifier located_in from PMID:21423176 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0003723 RNA binding
HDA
PMID:22658674
Insights into RNA biology from an atlas of mammalian mRNA-bi... 		MARK AS OVER ANNOTATED
Summary: RNA binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0003723 (RNA binding), the HDA annotation with qualifier enables from PMID:22658674 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0043235 signaling receptor complex
IDA
PMID:23382219
Structural basis for endosomal trafficking of diverse transm... 		ACCEPT
Summary: signaling receptor complex is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0043235 (signaling receptor complex), the IDA annotation with qualifier part_of from PMID:23382219 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005765 lysosomal membrane
HDA
PMID:17897319
Integral and associated lysosomal membrane proteins. 		ACCEPT
Summary: lysosomal membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005765 (lysosomal membrane), the HDA annotation with qualifier located_in from PMID:17897319 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-2168897 		ACCEPT
Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from Reactome:R-HSA-2168897 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-2230983 		ACCEPT
Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from Reactome:R-HSA-2230983 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-2404131 		ACCEPT
Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from Reactome:R-HSA-2404131 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030666 endocytic vesicle membrane
TAS
Reactome:R-HSA-2230983 		ACCEPT
Summary: endocytic vesicle membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0030666 (endocytic vesicle membrane), the TAS annotation with qualifier located_in from Reactome:R-HSA-2230983 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0097242 amyloid-beta clearance
TAS
PMID:19098903
SRF and myocardin regulate LRP-mediated amyloid-beta clearan... 		ACCEPT
Summary: amyloid-beta clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0097242 (amyloid-beta clearance), the TAS annotation with qualifier involved_in from PMID:19098903 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0014912 negative regulation of smooth muscle cell migration
ISS
GO_REF:0000024 		KEEP AS NON CORE
Summary: negative regulation of smooth muscle cell migration is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0014912 (negative regulation of smooth muscle cell migration), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032956 regulation of actin cytoskeleton organization
ISS
GO_REF:0000024 		KEEP AS NON CORE
Summary: regulation of actin cytoskeleton organization is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0032956 (regulation of actin cytoskeleton organization), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0035909 aorta morphogenesis
ISS
GO_REF:0000024 		KEEP AS NON CORE
Summary: aorta morphogenesis is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0035909 (aorta morphogenesis), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
ISS
GO_REF:0000024 		KEEP AS NON CORE
Summary: negative regulation of platelet-derived growth factor receptor-beta signaling pathway is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:2000587 (negative regulation of platelet-derived growth factor receptor-beta signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005509 calcium ion binding
ISS
GO_REF:0000024 		ACCEPT
Summary: calcium ion binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005509 (calcium ion binding), the ISS annotation with qualifier enables from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005886 plasma membrane
ISS
GO_REF:0000024 		ACCEPT
Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0005886 (plasma membrane), the ISS annotation with qualifier located_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0034185 apolipoprotein binding
IDA
PMID:2779654
The LDL-receptor-related protein, LRP, is an apolipoprotein ... 		ACCEPT
Summary: apolipoprotein binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0034185 (apolipoprotein binding), the IDA annotation with qualifier enables from PMID:2779654 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0042953 lipoprotein transport
NAS
PMID:3266596
Surface location and high affinity for calcium of a 500-kd l... 		ACCEPT
Summary: lipoprotein transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0042953 (lipoprotein transport), the NAS annotation with qualifier involved_in from PMID:3266596 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0044877 protein-containing complex binding
IDA
PMID:8626514
Plasminogen activator inhibitor-1 and vitronectin promote th... 		MARK AS OVER ANNOTATED
Summary: protein-containing complex binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0044877 (protein-containing complex binding), the IDA annotation with qualifier enables from PMID:8626514 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0010875 positive regulation of cholesterol efflux
ISS
GO_REF:0000024 		ACCEPT
Summary: positive regulation of cholesterol efflux is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0010875 (positive regulation of cholesterol efflux), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030178 negative regulation of Wnt signaling pathway
ISS
GO_REF:0000024 		KEEP AS NON CORE
Summary: negative regulation of Wnt signaling pathway is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0030178 (negative regulation of Wnt signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032370 positive regulation of lipid transport
ISS
GO_REF:0000024 		ACCEPT
Summary: positive regulation of lipid transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0032370 (positive regulation of lipid transport), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0043277 apoptotic cell clearance
ISS
GO_REF:0000024 		ACCEPT
Summary: apoptotic cell clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0043277 (apoptotic cell clearance), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0034185 apolipoprotein binding
IPI
PMID:18635818
Effects of six APOA5 variants, identified in patients with s... 		ACCEPT
Summary: apolipoprotein binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0034185 (apolipoprotein binding), the IPI annotation with qualifier enables from PMID:18635818 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0070325 lipoprotein particle receptor binding
IC
PMID:18635818
Effects of six APOA5 variants, identified in patients with s... 		ACCEPT
Summary: lipoprotein particle receptor binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0070325 (lipoprotein particle receptor binding), the IC annotation with qualifier enables from PMID:18635818 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0038023 signaling receptor activity
TAS
PMID:10880251
Involvement of alpha-2-macroglobulin receptor in clearance o... 		MARK AS OVER ANNOTATED
Summary: signaling receptor activity is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
Reason: For GO:0038023 (signaling receptor activity), the TAS annotation with qualifier enables from PMID:10880251 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.

Core Functions

Multifunctional LDLR-family endocytic cargo/scavenger receptor activity at the plasma membrane and coated pits, internalizing ligand complexes through receptor-mediated endocytosis and trafficking them through early endosomes and lysosomal/catabolic pathways.

Molecular Function:
cargo receptor activity
Directly Involved In:
receptor-mediated endocytosis receptor internalization phagocytosis positive regulation of lysosomal protein catabolic process
Cellular Locations:
plasma membrane early endosome endocytic vesicle membrane
Supporting Evidence:
  • file:human/LRP1/LRP1-uniprot.txt
    Endocytic receptor involved in endocytosis
  • PMID:3266596
    cell surface protein
  • PMID:3266596
    recycling lipoprotein receptor
  • PMID:8626514
    mediate the endocytosis of thrombin-PAI-1

Apolipoprotein/lipoprotein and calcium-dependent LDLR-family ligand receptor function supporting chylomicron-remnant/lipoprotein transport, lipid metabolism, cholesterol efflux, and reverse cholesterol transport.

Molecular Function:
apolipoprotein receptor activity
Directly Involved In:
lipoprotein transport positive regulation of lipid transport positive regulation of cholesterol efflux positive regulation of reverse cholesterol transport
Cellular Locations:
plasma membrane basolateral plasma membrane
Supporting Evidence:
  • file:human/LRP1/LRP1-uniprot.txt
    Involved in the plasma clearance
  • file:human/LRP1/LRP1-uniprot.txt
    chylomicron remnants
  • PMID:2779654
    apo E receptor
  • PMID:3266596
    strongly binds calcium

Alzheimer-relevant amyloid-beta binding, clearance, and transcytosis across vascular or cellular barriers, with UniProt-supported tau/MAPT receptor activity controlling tau endocytosis and spread as a related disease-relevant cargo branch.

Molecular Function:
amyloid-beta binding
Directly Involved In:
amyloid-beta clearance amyloid-beta clearance by cellular catabolic process amyloid-beta clearance by transcytosis transport across blood-brain barrier
Cellular Locations:
plasma membrane basolateral plasma membrane early endosome
Supporting Evidence:
  • PMID:19098903
    key Abeta clearance receptor
  • PMID:19098903
    controlling Abeta cerebrovascular clearance
  • file:human/LRP1/LRP1-uniprot.txt
    TAU/MAPT receptor
  • file:human/LRP1/LRP1-uniprot.txt
    endocytosis of TAU/MAPT

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000108
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
GO_REF:0000111
Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10772929
LDL receptor-related protein as a component of the midkine receptor.
PMID:10880251
Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages.
PMID:11240025
Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid.
PMID:12888553
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.
PMID:14645246
The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.
PMID:15182176
Two apolipoprotein E mimetic peptides, ApoE(130-149) and ApoE(141-155)2, bind to LRP1.
PMID:17326667
Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family.
PMID:17360663
HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.
PMID:17897319
Integral and associated lysosomal membrane proteins.
PMID:18635818
Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
PMID:19098903
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.
PMID:20005821
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
PMID:20030366
Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E.
PMID:20199584
Complement receptor 3 (CD11b/CD18) is implicated in the elimination of Ξ²-amyloid peptides.
PMID:20472562
Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.
PMID:21054788
CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site.
PMID:21289173
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.
PMID:21423176
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ξ²-Pix in negative regulation of focal adhesion maturation.
PMID:21968187
Phosphorylation of LRP1 regulates the interaction with Fe65.
PMID:22293988
Cellular prion protein participates in amyloid-Ξ² transcytosis across the blood-brain barrier.
PMID:22383525
Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of AΞ² uptake and degradation by astrocytes.
PMID:22658674
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
PMID:23152628
LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-Ξ².
PMID:23382219
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
PMID:23386614
Prion protein-mediated toxicity of amyloid-Ξ² oligomers requires lipid rafts and the transmembrane LRP1.
PMID:24284412
Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.
PMID:24305823
Neuronal clearance of amyloid-Ξ² by endocytic receptor LRP1.
PMID:26005850
Central role for PICALM in amyloid-Ξ² blood-brain barrier transcytosis and clearance.
PMID:26142438
Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans.
PMID:26590417
Establishment and Dysfunction of the Blood-Brain Barrier.
PMID:26781079
Clearance of matrix metalloproteinase-9 is dependent on low-density lipoprotein receptor-related protein-1 expression downregulated by microRNA-205 in human abdominal aortic aneurysm.
PMID:2779654
The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein.
PMID:28514442
Architecture of the human interactome defines protein communities and disease networks.
PMID:29547901
Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.
PMID:30280653
Blood-Brain Barrier: From Physiology to Disease and Back.
PMID:31023188
LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARΞ³ Activation.
PMID:31326693
The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response.
PMID:3266596
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:41162706
Multiple LDLRΒ family members act as entry receptors for yellow fever virus.
PMID:8626514
Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2.
Reactome:R-HSA-2168897
LRP1 (CD91) binds Hemopexin:heme
Reactome:R-HSA-2230983
LRP1:Hemopexin:heme is endocytosed
Reactome:R-HSA-2404131
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol
Reactome:R-HSA-975634
Retinoid metabolism and transport
file:human/LRP1/LRP1-uniprot.txt
UniProt text export for LRP1 (Q07954)
file:human/LRP1/LRP1-notes.md
Manual LRP1 review notes

Suggested Questions for Experts

Q: Which Alzheimer-relevant LRP1 effects are mediated by direct amyloid-beta/tau uptake versus indirect APOE/lipoprotein, vascular, or inflammatory pathways?

Q: Can tau/MAPT receptor activity and tau transcytosis/spread be represented with more specific GO terms than the current LRP1 GOA annotation set provides?

Q: Which LRP1 ligand classes should be prioritized as core in brain cell types: APOE lipoproteins, amyloid-beta species, tau, protease-inhibitor complexes, or extracellular-matrix-associated ligands?

Suggested Experiments

Experiment: Perturb LRP1 in human iPSC-derived endothelial cells, pericytes, astrocytes, microglia, and neurons, then separately measure APOE-lipoprotein uptake, amyloid-beta binding/clearance/transcytosis, tau uptake/spread, endosomal routing, and lysosomal degradation.

Hypothesis: LRP1 Alzheimer risk biology depends on cell-type-specific handling of amyloid-beta and tau cargo at vascular and glial barriers.

Type: cell-type-specific receptor-cargo trafficking assay

Experiment: Use endogenous motif-edited LRP1 constructs affecting NPXY/adaptor binding and regulated intramembrane cleavage to compare receptor internalization, cargo-specific uptake, intracellular-domain nuclear/cytoplasmic signaling, and downstream inflammatory or ECM responses.

Hypothesis: The LRP1 intracellular domain and adaptor-binding motifs tune cargo endocytosis versus signaling outputs.

Type: endogenous receptor motif rescue assay

πŸ“š Additional Documentation

Notes

(LRP1-notes.md)

LRP1 notes

Automated deep research was attempted with just deep-research-falcon human LRP1 --fallback perplexity-lite, but the run timed out before producing a deep-research file. This review therefore uses cached GOA publications, the UniProt record, and the PANTHER family fetch.

LRP1 encodes low-density lipoprotein receptor-related protein 1, a large LDL receptor-family cell-surface/endocytic receptor that is proteolytically processed into extracellular and membrane/cytoplasmic subunits. UniProt describes LRP1 as an "Endocytic receptor involved in endocytosis" and notes roles in lipid homeostasis, chylomicron-remnant clearance, alpha-2-macroglobulin receptor activity, ligand-complex metabolism, and tau uptake/spread [file:human/LRP1/LRP1-uniprot.txt "Endocytic receptor involved in endocytosis"; file:human/LRP1/LRP1-uniprot.txt "Involved in the plasma clearance"; file:human/LRP1/LRP1-uniprot.txt "chylomicron remnants"; file:human/LRP1/LRP1-uniprot.txt "macroglobulin receptor"; file:human/LRP1/LRP1-uniprot.txt "TAU/MAPT receptor"; file:human/LRP1/LRP1-uniprot.txt "endocytosis of TAU/MAPT"; file:human/LRP1/LRP1-uniprot.txt "subsequent spread"]. PANTHER places human LRP1 in PTHR22722, the LDLR-related family.

The original LDL receptor-related protein paper supports the receptor architecture and localization: it describes a "cell surface protein", calcium binding, and proposes that LRP is a "recycling lipoprotein receptor" [PMID:3266596 "cell surface protein"; PMID:3266596 "strongly binds calcium"; PMID:3266596 "recycling lipoprotein receptor"]. The APOE paper supports apolipoprotein receptor biology by concluding that LRP "might function as an apo E receptor" and showing apoE-liposome binding "specifically to the cell surface" [PMID:2779654 "apo E receptor"; PMID:2779654 "specifically to the cell surface"].

Endocytic clearance of protease/inhibitor and other ligand complexes is also central. The thrombin/PAI-1 paper reports that LRP1/LRP2 "mediate the endocytosis of thrombin-PAI-1" and discusses "LRP-mediated clearance" and "cellular clearance of thrombin" [PMID:8626514 "mediate the endocytosis of thrombin-PAI-1"; PMID:8626514 "LRP-mediated clearance"; PMID:8626514 "cellular clearance of thrombin"]. UniProt also places LRP1 at the cell membrane, coated pits, and cytoplasmic/nuclear compartments after intracellular-domain cleavage [file:human/LRP1/LRP1-uniprot.txt "Cell membrane; Single-pass type I membrane protein"; file:human/LRP1/LRP1-uniprot.txt "Membrane, coated pit"; file:human/LRP1/LRP1-uniprot.txt "detected both in the cytoplasm"].

For Alzheimer disease, the strongest LRP1-specific GOA evidence concerns amyloid-beta clearance and transcytosis at vascular/cellular barriers, plus tau uptake/spread. Bell et al. call LRP a "key Abeta clearance receptor" and describe SRF/MYOCD control of "Abeta cerebrovascular clearance" [PMID:19098903 "key Abeta clearance receptor"; PMID:19098903 "controlling Abeta cerebrovascular clearance"]. The PrP/AΞ² oligomer study reports dependence on "transmembrane low density lipoprotein receptor-related protein-1 (LRP1)" and states "LRP1 is also critical" for AΞ² oligomer-mediated cytotoxicity [PMID:23386614 "transmembrane low density lipoprotein receptor-related protein-1 (LRP1)"; PMID:23386614 "LRP1 is also critical"; PMID:23386614 "AΞ² oligomers"].

For curation, accept core receptor/ligand-binding, cargo receptor, scavenger/apolipoprotein/LDL receptor, calcium-dependent ligand-binding, receptor-mediated endocytosis/internalization, amyloid-beta clearance/transcytosis, lipoprotein/lipid transport, phagocytosis/apoptotic-cell clearance, and plasma membrane/coated-pit/endosome localization. Keep signaling, extracellular matrix, smooth-muscle/aorta, inflammatory, viral/toxin receptor, focal adhesion, nucleolar/cytosolic/nuclear intracellular-domain, and postsynaptic Golgi/MTOC annotations as non-core. Mark generic protein binding and RNA binding as over-annotated.

2026-06-20 second-pass audit

The second-pass audit confirmed the existing LRP1 review and manual reference metadata. No annotation action changes were needed: LRP1 remains curated as a multifunctional LDLR-family cargo/endocytic receptor for apolipoprotein, scavenger, amyloid-beta, tau, and ligand-complex clearance, with signaling, extracellular-matrix, inflammatory, viral/toxin, intracellular-domain, and generic binding annotations retained as non-core or over-annotated where appropriate.

πŸ“„ View Raw YAML

 
id: Q07954
gene_symbol: LRP1
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'LRP1 encodes low-density lipoprotein receptor-related protein 1, a large
  LDL receptor-family type I membrane receptor that is proteolytically processed into
  extracellular ligand-binding and membrane/cytoplasmic subunits. LRP1 acts as a multifunctional
  endocytic, cargo, scavenger, apolipoprotein/lipoprotein, and alpha-2-macroglobulin
  receptor, concentrating ligands at the plasma membrane and clathrin-coated pits
  for receptor-mediated internalization, endosomal trafficking, lysosomal clearance,
  phagocytosis, and lipid transport. In Alzheimer-relevant biology, LRP1 participates
  in amyloid-beta binding, clearance, and transcytosis across vascular and cellular
  barriers, and UniProt also describes it as a tau/MAPT receptor controlling tau endocytosis
  and spread.'
alternative_products:
- name: '1'
  id: Q07954-1
- name: '2'
  id: Q07954-2
  sequence_note: VSP_056919, VSP_056920
existing_annotations:
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: is_active_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the IBA annotation with qualifier is_active_in
      from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006898
    label: receptor-mediated endocytosis
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      receptor-mediated endocytosis is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006898 (receptor-mediated endocytosis), the IBA annotation with qualifier
      involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006909
    label: phagocytosis
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      phagocytosis is retained as a core biological-process annotation for LRP1; it
      captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006909 (phagocytosis), the IBA annotation with qualifier involved_in
      from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0034185
    label: apolipoprotein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: enables
  review:
    summary: >-
      apolipoprotein binding is retained as a core molecular-function annotation for
      LRP1; it captures activity or binding specificity within the synthesized core
      biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and
      calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0034185 (apolipoprotein binding), the IBA annotation with qualifier enables
      from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0038024
    label: cargo receptor activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: enables
  review:
    summary: >-
      cargo receptor activity is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0038024 (cargo receptor activity), the IBA annotation with qualifier
      enables from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150093
    label: amyloid-beta clearance by transcytosis
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance by transcytosis is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150093 (amyloid-beta clearance by transcytosis), the IBA annotation
      with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core
      role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150094
    label: amyloid-beta clearance by cellular catabolic process
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance by cellular catabolic process is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IBA
      annotation with qualifier involved_in from GO_REF:0000033 is consistent with
      LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0001523
    label: retinoid metabolic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      retinoid metabolic process is retained as a non-core biological-process annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0001523 (retinoid metabolic process), the IEA annotation with qualifier
      involved_in from GO_REF:0000117 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. Keeping it as non-core prevents broad pathway participation
      from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005041
    label: low-density lipoprotein particle receptor activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: enables
  review:
    summary: >-
      low-density lipoprotein particle receptor activity is retained as a core molecular-function
      annotation for LRP1; it captures activity or binding specificity within the
      synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005041 (low-density lipoprotein particle receptor activity), the IEA
      annotation with qualifier enables from GO_REF:0000117 is consistent with LRP1's
      core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005509
    label: calcium ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  qualifier: enables
  review:
    summary: >-
      calcium ion binding is retained as a core molecular-function annotation for
      LRP1; it captures activity or binding specificity within the synthesized core
      biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and
      calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005509 (calcium ion binding), the IEA annotation with qualifier enables
      from GO_REF:0000002 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  qualifier: located_in
  review:
    summary: >-
      nucleus is retained as a non-core cellular-component/localization annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005634 (nucleus), the IEA annotation with qualifier located_in from
      GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal LRP1 function: LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a non-core cellular-component/localization annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005737 (cytoplasm), the IEA annotation with qualifier located_in from
      GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal LRP1 function: LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005769
    label: early endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: located_in
  review:
    summary: >-
      early endosome is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005769 (early endosome), the IEA annotation with qualifier located_in
      from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005815
    label: microtubule organizing center
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  qualifier: located_in
  review:
    summary: >-
      microtubule organizing center is retained as a non-core cellular-component/localization
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005815 (microtubule organizing center), the IEA annotation with qualifier
      located_in from GO_REF:0000044 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. Keeping it as non-core prevents broad pathway participation
      from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in
      from GO_REF:0000120 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006898
    label: receptor-mediated endocytosis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      receptor-mediated endocytosis is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006898 (receptor-mediated endocytosis), the IEA annotation with qualifier
      involved_in from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0016020
    label: membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  qualifier: located_in
  review:
    summary: >-
      membrane is retained as a core cellular-component/localization annotation for
      LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0016020 (membrane), the IEA annotation with qualifier located_in from
      GO_REF:0000044 is consistent with LRP1's core role in LDLR-family ligand binding
      and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0030100
    label: regulation of endocytosis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      regulation of endocytosis is retained as a non-core biological-process annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030100 (regulation of endocytosis), the IEA annotation with qualifier
      involved_in from GO_REF:0000117 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. Keeping it as non-core prevents broad pathway participation
      from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0032050
    label: clathrin heavy chain binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: enables
  review:
    summary: >-
      clathrin heavy chain binding is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0032050 (clathrin heavy chain binding), the IEA annotation with qualifier
      enables from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: enables
  review:
    summary: >-
      protein-containing complex binding is marked over-annotated for LRP1 because
      this molecular-function term is too generic, interaction-map-like, or weakly
      informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0044877 (protein-containing complex binding), the IEA annotation with
      qualifier enables from GO_REF:0000117 may reflect a real assay result or interaction,
      but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0046718
    label: symbiont entry into host cell
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  qualifier: involved_in
  review:
    summary: >-
      symbiont entry into host cell is retained as a non-core biological-process annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0046718 (symbiont entry into host cell), the IEA annotation with qualifier
      involved_in from GO_REF:0000108 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. Keeping it as non-core prevents broad pathway participation
      from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0051050
    label: positive regulation of transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of transport is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0051050 (positive regulation of transport), the IEA annotation with qualifier
      involved_in from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0051246
    label: regulation of protein metabolic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      regulation of protein metabolic process is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0051246 (regulation of protein metabolic process), the IEA annotation
      with qualifier involved_in from GO_REF:0000117 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15182176
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:15182176 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17326667
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:17326667 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17360663
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:17360663 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20030366
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:20030366 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20472562
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:20472562 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21054788
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21054788 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21968187
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21968187 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24284412
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:24284412 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28514442
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:28514442 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:29547901
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:29547901 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:33961781 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0002673
    label: regulation of acute inflammatory response
  evidence_type: IDA
  original_reference_id: PMID:31326693
  qualifier: involved_in
  review:
    summary: >-
      regulation of acute inflammatory response is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0002673 (regulation of acute inflammatory response), the IDA annotation
      with qualifier involved_in from PMID:31326693 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0038024
    label: cargo receptor activity
  evidence_type: IDA
  original_reference_id: PMID:31326693
  qualifier: enables
  review:
    summary: >-
      cargo receptor activity is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0038024 (cargo receptor activity), the IDA annotation with qualifier
      enables from PMID:31326693 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0001523
    label: retinoid metabolic process
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-975634
  qualifier: involved_in
  review:
    summary: >-
      retinoid metabolic process is retained as a non-core biological-process annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0001523 (retinoid metabolic process), the TAS annotation with qualifier
      involved_in from Reactome:R-HSA-975634 supports retaining the annotation, but
      the term describes a context-specific outcome or peripheral branch rather than
      the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  qualifier: located_in
  review:
    summary: >-
      nucleolus is retained as a non-core cellular-component/localization annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005730 (nucleolus), the IDA annotation with qualifier located_in from
      GO_REF:0000052 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal LRP1 function: LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a non-core cellular-component/localization annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005829 (cytosol), the IDA annotation with qualifier located_in from
      GO_REF:0000052 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal LRP1 function: LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in
      from GO_REF:0000052 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0001618
    label: virus receptor activity
  evidence_type: IMP
  original_reference_id: PMID:41162706
  qualifier: enables
  review:
    summary: >-
      virus receptor activity is retained as a non-core molecular-function annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0001618 (virus receptor activity), the IMP annotation with qualifier
      enables from PMID:41162706 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal LRP1
      function: LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. Keeping it as non-core prevents broad pathway participation
      from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: EXP
  original_reference_id: PMID:12888553
  qualifier: located_in
  review:
    summary: >-
      nucleus is retained as a non-core cellular-component/localization annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005634 (nucleus), the EXP annotation with qualifier located_in from
      PMID:12888553 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal LRP1 function: LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: EXP
  original_reference_id: PMID:12888553
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a non-core cellular-component/localization annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from
      PMID:12888553 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal LRP1 function: LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0150051
    label: postsynaptic Golgi apparatus
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: located_in
  review:
    summary: >-
      postsynaptic Golgi apparatus is retained as a non-core cellular-component/localization
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0150051 (postsynaptic Golgi apparatus), the ISS annotation with qualifier
      located_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. Keeping it as non-core prevents broad pathway participation
      from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:1903064
    label: positive regulation of reverse cholesterol transport
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of reverse cholesterol transport is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:1903064 (positive regulation of reverse cholesterol transport), the ISS
      annotation with qualifier involved_in from GO_REF:0000024 is consistent with
      LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006898
    label: receptor-mediated endocytosis
  evidence_type: IMP
  original_reference_id: PMID:26781079
  qualifier: involved_in
  review:
    summary: >-
      receptor-mediated endocytosis is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier
      involved_in from PMID:26781079 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:1903053
    label: regulation of extracellular matrix organization
  evidence_type: IMP
  original_reference_id: PMID:26781079
  qualifier: acts_upstream_of
  review:
    summary: >-
      regulation of extracellular matrix organization is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1903053 (regulation of extracellular matrix organization), the IMP annotation
      with qualifier acts_upstream_of from PMID:26781079 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0060392
    label: negative regulation of SMAD protein signal transduction
  evidence_type: ISS
  original_reference_id: PMID:31023188
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of SMAD protein signal transduction is retained as a non-core
      biological-process annotation for LRP1; it records a supported context, interaction,
      localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0060392 (negative regulation of SMAD protein signal transduction), the
      ISS annotation with qualifier involved_in from PMID:31023188 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal LRP1 function: LDLR-family ligand binding and
      receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it
      as non-core prevents broad pathway participation from being promoted to core
      function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0007167
    label: enzyme-linked receptor protein signaling pathway
  evidence_type: ISS
  original_reference_id: PMID:31023188
  qualifier: involved_in
  review:
    summary: >-
      enzyme-linked receptor protein signaling pathway is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0007167 (enzyme-linked receptor protein signaling pathway), the ISS annotation
      with qualifier involved_in from PMID:31023188 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0010629
    label: negative regulation of gene expression
  evidence_type: ISS
  original_reference_id: PMID:31023188
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of gene expression is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010629 (negative regulation of gene expression), the ISS annotation
      with qualifier involved_in from PMID:31023188 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005041
    label: low-density lipoprotein particle receptor activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2404131
  qualifier: enables
  review:
    summary: >-
      low-density lipoprotein particle receptor activity is retained as a core molecular-function
      annotation for LRP1; it captures activity or binding specificity within the
      synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005041 (low-density lipoprotein particle receptor activity), the TAS
      annotation with qualifier enables from Reactome:R-HSA-2404131 is consistent
      with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006629
    label: lipid metabolic process
  evidence_type: TAS
  original_reference_id: PMID:21289173
  qualifier: involved_in
  review:
    summary: >-
      lipid metabolic process is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006629 (lipid metabolic process), the TAS annotation with qualifier
      involved_in from PMID:21289173 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0043395
    label: heparan sulfate proteoglycan binding
  evidence_type: TAS
  original_reference_id: PMID:21289173
  qualifier: enables
  review:
    summary: >-
      heparan sulfate proteoglycan binding is retained as a core molecular-function
      annotation for LRP1; it captures activity or binding specificity within the
      synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0043395 (heparan sulfate proteoglycan binding), the TAS annotation with
      qualifier enables from PMID:21289173 is consistent with LRP1's core role in
      LDLR-family ligand binding and receptor-mediated internalization/clearance of
      lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150104
    label: transport across blood-brain barrier
  evidence_type: NAS
  original_reference_id: PMID:30280653
  qualifier: involved_in
  review:
    summary: >-
      transport across blood-brain barrier is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150104 (transport across blood-brain barrier), the NAS annotation with
      qualifier involved_in from PMID:30280653 is consistent with LRP1's core role
      in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150104
    label: transport across blood-brain barrier
  evidence_type: NAS
  original_reference_id: PMID:26590417
  qualifier: involved_in
  review:
    summary: >-
      transport across blood-brain barrier is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150104 (transport across blood-brain barrier), the NAS annotation with
      qualifier involved_in from PMID:26590417 is consistent with LRP1's core role
      in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26005850
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:26005850 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0032050
    label: clathrin heavy chain binding
  evidence_type: IPI
  original_reference_id: PMID:26005850
  qualifier: enables
  review:
    summary: >-
      clathrin heavy chain binding is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0032050 (clathrin heavy chain binding), the IPI annotation with qualifier
      enables from PMID:26005850 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150093
    label: amyloid-beta clearance by transcytosis
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance by transcytosis is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150093 (amyloid-beta clearance by transcytosis), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core
      role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150104
    label: transport across blood-brain barrier
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      transport across blood-brain barrier is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150104 (transport across blood-brain barrier), the ISS annotation with
      qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role
      in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:1900223
    label: positive regulation of amyloid-beta clearance
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of amyloid-beta clearance is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:1900223 (positive regulation of amyloid-beta clearance), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core
      role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:1904300
    label: positive regulation of transcytosis
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of transcytosis is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:1904300 (positive regulation of transcytosis), the ISS annotation with
      qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role
      in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0038024
    label: cargo receptor activity
  evidence_type: NAS
  original_reference_id: PMID:3266596
  qualifier: enables
  review:
    summary: >-
      cargo receptor activity is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0038024 (cargo receptor activity), the NAS annotation with qualifier
      enables from PMID:3266596 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10772929
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:10772929 may reflect a real assay result or interaction, but this
      GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0007041
    label: lysosomal transport
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      lysosomal transport is retained as a core biological-process annotation for
      LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0007041 (lysosomal transport), the ISS annotation with qualifier involved_in
      from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0001540
    label: amyloid-beta binding
  evidence_type: IC
  original_reference_id: GO_REF:0000111
  qualifier: enables
  review:
    summary: >-
      amyloid-beta binding is retained as a core molecular-function annotation for
      LRP1; it captures activity or binding specificity within the synthesized core
      biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and
      calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0001540 (amyloid-beta binding), the IC annotation with qualifier enables
      from GO_REF:0000111 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0002265
    label: astrocyte activation involved in immune response
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      astrocyte activation involved in immune response is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0002265 (astrocyte activation involved in immune response), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0006898
    label: receptor-mediated endocytosis
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      receptor-mediated endocytosis is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006898 (receptor-mediated endocytosis), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006898
    label: receptor-mediated endocytosis
  evidence_type: IMP
  original_reference_id: PMID:23152628
  qualifier: involved_in
  review:
    summary: >-
      receptor-mediated endocytosis is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier
      involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006898
    label: receptor-mediated endocytosis
  evidence_type: IMP
  original_reference_id: PMID:24305823
  qualifier: involved_in
  review:
    summary: >-
      receptor-mediated endocytosis is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier
      involved_in from PMID:24305823 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006898
    label: receptor-mediated endocytosis
  evidence_type: IMP
  original_reference_id: PMID:26005850
  qualifier: involved_in
  review:
    summary: >-
      receptor-mediated endocytosis is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier
      involved_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006909
    label: phagocytosis
  evidence_type: IMP
  original_reference_id: PMID:23152628
  qualifier: involved_in
  review:
    summary: >-
      phagocytosis is retained as a core biological-process annotation for LRP1; it
      captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006909 (phagocytosis), the IMP annotation with qualifier involved_in
      from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0038024
    label: cargo receptor activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: enables
  review:
    summary: >-
      cargo receptor activity is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0038024 (cargo receptor activity), the ISS annotation with qualifier
      enables from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0038024
    label: cargo receptor activity
  evidence_type: IMP
  original_reference_id: PMID:23152628
  qualifier: enables
  review:
    summary: >-
      cargo receptor activity is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0038024 (cargo receptor activity), the IMP annotation with qualifier
      enables from PMID:23152628 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0038024
    label: cargo receptor activity
  evidence_type: IMP
  original_reference_id: PMID:24305823
  qualifier: enables
  review:
    summary: >-
      cargo receptor activity is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0038024 (cargo receptor activity), the IMP annotation with qualifier
      enables from PMID:24305823 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150093
    label: amyloid-beta clearance by transcytosis
  evidence_type: IGI
  original_reference_id: PMID:26005850
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance by transcytosis is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150093 (amyloid-beta clearance by transcytosis), the IGI annotation
      with qualifier involved_in from PMID:26005850 is consistent with LRP1's core
      role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150094
    label: amyloid-beta clearance by cellular catabolic process
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance by cellular catabolic process is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the ISS
      annotation with qualifier involved_in from GO_REF:0000024 is consistent with
      LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150094
    label: amyloid-beta clearance by cellular catabolic process
  evidence_type: IMP
  original_reference_id: PMID:23152628
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance by cellular catabolic process is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IMP
      annotation with qualifier involved_in from PMID:23152628 is consistent with
      LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0150094
    label: amyloid-beta clearance by cellular catabolic process
  evidence_type: IMP
  original_reference_id: PMID:24305823
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance by cellular catabolic process is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IMP
      annotation with qualifier involved_in from PMID:24305823 is consistent with
      LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:1904646
    label: cellular response to amyloid-beta
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      cellular response to amyloid-beta is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1904646 (cellular response to amyloid-beta), the ISS annotation with
      qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:1905167
    label: positive regulation of lysosomal protein catabolic process
  evidence_type: IMP
  original_reference_id: PMID:23152628
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of lysosomal protein catabolic process is retained as a
      core biological-process annotation for LRP1; it captures process participation
      within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:1905167 (positive regulation of lysosomal protein catabolic process),
      the IMP annotation with qualifier involved_in from PMID:23152628 is consistent
      with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:1903078
    label: positive regulation of protein localization to plasma membrane
  evidence_type: IGI
  original_reference_id: PMID:23386614
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein localization to plasma membrane is retained as
      a non-core biological-process annotation for LRP1; it records a supported context,
      interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1903078 (positive regulation of protein localization to plasma membrane),
      the IGI annotation with qualifier involved_in from PMID:23386614 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal LRP1 function: LDLR-family ligand binding and
      receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it
      as non-core prevents broad pathway participation from being promoted to core
      function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0045807
    label: positive regulation of endocytosis
  evidence_type: IGI
  original_reference_id: PMID:23386614
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of endocytosis is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0045807 (positive regulation of endocytosis), the IGI annotation with
      qualifier involved_in from PMID:23386614 is consistent with LRP1's core role
      in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0006909
    label: phagocytosis
  evidence_type: NAS
  original_reference_id: PMID:20199584
  qualifier: involved_in
  review:
    summary: >-
      phagocytosis is retained as a core biological-process annotation for LRP1; it
      captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0006909 (phagocytosis), the NAS annotation with qualifier involved_in
      from PMID:20199584 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0097242
    label: amyloid-beta clearance
  evidence_type: NAS
  original_reference_id: PMID:20199584
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance is retained as a core biological-process annotation for
      LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0097242 (amyloid-beta clearance), the NAS annotation with qualifier involved_in
      from PMID:20199584 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:1900223
    label: positive regulation of amyloid-beta clearance
  evidence_type: TAS
  original_reference_id: PMID:22383525
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of amyloid-beta clearance is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:1900223 (positive regulation of amyloid-beta clearance), the TAS annotation
      with qualifier involved_in from PMID:22383525 is consistent with LRP1's core
      role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005041
    label: low-density lipoprotein particle receptor activity
  evidence_type: TAS
  original_reference_id: PMID:20005821
  qualifier: enables
  review:
    summary: >-
      low-density lipoprotein particle receptor activity is retained as a core molecular-function
      annotation for LRP1; it captures activity or binding specificity within the
      synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005041 (low-density lipoprotein particle receptor activity), the TAS
      annotation with qualifier enables from PMID:20005821 is consistent with LRP1's
      core role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005044
    label: scavenger receptor activity
  evidence_type: TAS
  original_reference_id: PMID:11240025
  qualifier: enables
  review:
    summary: >-
      scavenger receptor activity is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005044 (scavenger receptor activity), the TAS annotation with qualifier
      enables from PMID:11240025 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005769
    label: early endosome
  evidence_type: IDA
  original_reference_id: PMID:26005850
  qualifier: located_in
  review:
    summary: >-
      early endosome is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005769 (early endosome), the IDA annotation with qualifier located_in
      from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0016323
    label: basolateral plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:26005850
  qualifier: located_in
  review:
    summary: >-
      basolateral plasma membrane is retained as a core cellular-component/localization
      annotation for LRP1; it captures site of action or component context within
      the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0016323 (basolateral plasma membrane), the IDA annotation with qualifier
      located_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0016964
    label: alpha-2 macroglobulin receptor activity
  evidence_type: TAS
  original_reference_id: PMID:21289173
  qualifier: enables
  review:
    summary: >-
      alpha-2 macroglobulin receptor activity is retained as a core molecular-function
      annotation for LRP1; it captures activity or binding specificity within the
      synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0016964 (alpha-2 macroglobulin receptor activity), the TAS annotation
      with qualifier enables from PMID:21289173 is consistent with LRP1's core role
      in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0030226
    label: apolipoprotein receptor activity
  evidence_type: TAS
  original_reference_id: PMID:21289173
  qualifier: enables
  review:
    summary: >-
      apolipoprotein receptor activity is retained as a core molecular-function annotation
      for LRP1; it captures activity or binding specificity within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0030226 (apolipoprotein receptor activity), the TAS annotation with qualifier
      enables from PMID:21289173 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0098797
    label: plasma membrane protein complex
  evidence_type: TAS
  original_reference_id: PMID:21289173
  qualifier: part_of
  review:
    summary: >-
      plasma membrane protein complex is retained as a core cellular-component/localization
      annotation for LRP1; it captures site of action or component context within
      the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0098797 (plasma membrane protein complex), the TAS annotation with qualifier
      part_of from PMID:21289173 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0016964
    label: alpha-2 macroglobulin receptor activity
  evidence_type: IMP
  original_reference_id: PMID:26142438
  qualifier: enables
  review:
    summary: >-
      alpha-2 macroglobulin receptor activity is retained as a core molecular-function
      annotation for LRP1; it captures activity or binding specificity within the
      synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0016964 (alpha-2 macroglobulin receptor activity), the IMP annotation
      with qualifier enables from PMID:26142438 is consistent with LRP1's core role
      in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0031623
    label: receptor internalization
  evidence_type: TAS
  original_reference_id: PMID:22293988
  qualifier: involved_in
  review:
    summary: >-
      receptor internalization is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0031623 (receptor internalization), the TAS annotation with qualifier
      involved_in from PMID:22293988 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0045056
    label: transcytosis
  evidence_type: TAS
  original_reference_id: PMID:22293988
  qualifier: involved_in
  review:
    summary: >-
      transcytosis is retained as a core biological-process annotation for LRP1; it
      captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0045056 (transcytosis), the TAS annotation with qualifier involved_in
      from PMID:22293988 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0016020
    label: membrane
  evidence_type: NAS
  original_reference_id: PMID:23386614
  qualifier: located_in
  review:
    summary: >-
      membrane is retained as a core cellular-component/localization annotation for
      LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0016020 (membrane), the NAS annotation with qualifier located_in from
      PMID:23386614 is consistent with LRP1's core role in LDLR-family ligand binding
      and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: TAS
  original_reference_id: PMID:14645246
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in
      from PMID:14645246 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0010715
    label: regulation of extracellular matrix disassembly
  evidence_type: TAS
  original_reference_id: PMID:14645246
  qualifier: involved_in
  review:
    summary: >-
      regulation of extracellular matrix disassembly is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010715 (regulation of extracellular matrix disassembly), the TAS annotation
      with qualifier involved_in from PMID:14645246 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8626514
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:8626514 may reflect a real assay result or interaction, but this GO
      term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: HDA
  original_reference_id: PMID:21423176
  qualifier: located_in
  review:
    summary: >-
      focal adhesion is retained as a non-core cellular-component/localization annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005925 (focal adhesion), the HDA annotation with qualifier located_in
      from PMID:21423176 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal LRP1
      function: LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. Keeping it as non-core prevents broad pathway participation
      from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: HDA
  original_reference_id: PMID:22658674
  qualifier: enables
  review:
    summary: >-
      RNA binding is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0003723 (RNA binding), the HDA annotation with qualifier enables from
      PMID:22658674 may reflect a real assay result or interaction, but this GO term
      does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic,
      or localization annotation that explains LRP1's role in LDLR-family ligand binding
      and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative
      gene-specific annotations are present, so this is marked over-annotated rather
      than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0043235
    label: signaling receptor complex
  evidence_type: IDA
  original_reference_id: PMID:23382219
  qualifier: part_of
  review:
    summary: >-
      signaling receptor complex is retained as a core cellular-component/localization
      annotation for LRP1; it captures site of action or component context within
      the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0043235 (signaling receptor complex), the IDA annotation with qualifier
      part_of from PMID:23382219 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005765
    label: lysosomal membrane
  evidence_type: HDA
  original_reference_id: PMID:17897319
  qualifier: located_in
  review:
    summary: >-
      lysosomal membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005765 (lysosomal membrane), the HDA annotation with qualifier located_in
      from PMID:17897319 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2168897
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in
      from Reactome:R-HSA-2168897 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2230983
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in
      from Reactome:R-HSA-2230983 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2404131
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in
      from Reactome:R-HSA-2404131 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0030666
    label: endocytic vesicle membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2230983
  qualifier: located_in
  review:
    summary: >-
      endocytic vesicle membrane is retained as a core cellular-component/localization
      annotation for LRP1; it captures site of action or component context within
      the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0030666 (endocytic vesicle membrane), the TAS annotation with qualifier
      located_in from Reactome:R-HSA-2230983 is consistent with LRP1's core role in
      LDLR-family ligand binding and receptor-mediated internalization/clearance of
      lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0097242
    label: amyloid-beta clearance
  evidence_type: TAS
  original_reference_id: PMID:19098903
  qualifier: involved_in
  review:
    summary: >-
      amyloid-beta clearance is retained as a core biological-process annotation for
      LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0097242 (amyloid-beta clearance), the TAS annotation with qualifier involved_in
      from PMID:19098903 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0014912
    label: negative regulation of smooth muscle cell migration
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of smooth muscle cell migration is retained as a non-core
      biological-process annotation for LRP1; it records a supported context, interaction,
      localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0014912 (negative regulation of smooth muscle cell migration), the ISS
      annotation with qualifier involved_in from GO_REF:0000024 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal LRP1 function: LDLR-family ligand binding and
      receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it
      as non-core prevents broad pathway participation from being promoted to core
      function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0032956
    label: regulation of actin cytoskeleton organization
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      regulation of actin cytoskeleton organization is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0032956 (regulation of actin cytoskeleton organization), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0035909
    label: aorta morphogenesis
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      aorta morphogenesis is retained as a non-core biological-process annotation
      for LRP1; it records a supported context, interaction, localization, or pathway
      branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor
      biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0035909 (aorta morphogenesis), the ISS annotation with qualifier involved_in
      from GO_REF:0000024 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal LRP1
      function: LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. Keeping it as non-core prevents broad pathway participation
      from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:2000587
    label: negative regulation of platelet-derived growth factor receptor-beta 
      signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of platelet-derived growth factor receptor-beta signaling
      pathway is retained as a non-core biological-process annotation for LRP1; it
      records a supported context, interaction, localization, or pathway branch that
      is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:2000587 (negative regulation of platelet-derived growth factor receptor-beta
      signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024
      supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal LRP1 function: LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0005509
    label: calcium ion binding
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: enables
  review:
    summary: >-
      calcium ion binding is retained as a core molecular-function annotation for
      LRP1; it captures activity or binding specificity within the synthesized core
      biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and
      calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005509 (calcium ion binding), the ISS annotation with qualifier enables
      from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for LRP1; it captures site of action or component context within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the ISS annotation with qualifier located_in
      from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0034185
    label: apolipoprotein binding
  evidence_type: IDA
  original_reference_id: PMID:2779654
  qualifier: enables
  review:
    summary: >-
      apolipoprotein binding is retained as a core molecular-function annotation for
      LRP1; it captures activity or binding specificity within the synthesized core
      biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and
      calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0034185 (apolipoprotein binding), the IDA annotation with qualifier enables
      from PMID:2779654 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0042953
    label: lipoprotein transport
  evidence_type: NAS
  original_reference_id: PMID:3266596
  qualifier: involved_in
  review:
    summary: >-
      lipoprotein transport is retained as a core biological-process annotation for
      LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0042953 (lipoprotein transport), the NAS annotation with qualifier involved_in
      from PMID:3266596 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: IDA
  original_reference_id: PMID:8626514
  qualifier: enables
  review:
    summary: >-
      protein-containing complex binding is marked over-annotated for LRP1 because
      this molecular-function term is too generic, interaction-map-like, or weakly
      informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0044877 (protein-containing complex binding), the IDA annotation with
      qualifier enables from PMID:8626514 may reflect a real assay result or interaction,
      but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0010875
    label: positive regulation of cholesterol efflux
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of cholesterol efflux is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0010875 (positive regulation of cholesterol efflux), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core
      role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0030178
    label: negative regulation of Wnt signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of Wnt signaling pathway is retained as a non-core biological-process
      annotation for LRP1; it records a supported context, interaction, localization,
      or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal
      receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and
      alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis,
      phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030178 (negative regulation of Wnt signaling pathway), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated
      internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor,
      amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents
      broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-uniprot.txt
    - file:human/LRP1/LRP1-notes.md
- term:
    id: GO:0032370
    label: positive regulation of lipid transport
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of lipid transport is retained as a core biological-process
      annotation for LRP1; it captures process participation within the synthesized
      core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand
      and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0032370 (positive regulation of lipid transport), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core
      role in LDLR-family ligand binding and receptor-mediated internalization/clearance
      of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0043277
    label: apoptotic cell clearance
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      apoptotic cell clearance is retained as a core biological-process annotation
      for LRP1; it captures process participation within the synthesized core biology:
      LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium
      binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition,
      receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance,
      and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0043277 (apoptotic cell clearance), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      This action keeps the term because it provides a specific, evidence-backed receptor,
      ligand-binding, cargo-clearance, endocytic, or localization annotation rather
      than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0034185
    label: apolipoprotein binding
  evidence_type: IPI
  original_reference_id: PMID:18635818
  qualifier: enables
  review:
    summary: >-
      apolipoprotein binding is retained as a core molecular-function annotation for
      LRP1; it captures activity or binding specificity within the synthesized core
      biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and
      calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo
      recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0034185 (apolipoprotein binding), the IPI annotation with qualifier enables
      from PMID:18635818 is consistent with LRP1's core role in LDLR-family ligand
      binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein,
      protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action
      keeps the term because it provides a specific, evidence-backed receptor, ligand-binding,
      cargo-clearance, endocytic, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0070325
    label: lipoprotein particle receptor binding
  evidence_type: IC
  original_reference_id: PMID:18635818
  qualifier: enables
  review:
    summary: >-
      lipoprotein particle receptor binding is retained as a core molecular-function
      annotation for LRP1; it captures activity or binding specificity within the
      synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: ACCEPT
    reason: >-
      For GO:0070325 (lipoprotein particle receptor binding), the IC annotation with
      qualifier enables from PMID:18635818 is consistent with LRP1's core role in
      LDLR-family ligand binding and receptor-mediated internalization/clearance of
      lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other
      cargo complexes. This action keeps the term because it provides a specific,
      evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:3266596
    - PMID:2779654
    - PMID:8626514
    - PMID:19098903
    - file:human/LRP1/LRP1-uniprot.txt
- term:
    id: GO:0038023
    label: signaling receptor activity
  evidence_type: TAS
  original_reference_id: PMID:10880251
  qualifier: enables
  review:
    summary: >-
      signaling receptor activity is marked over-annotated for LRP1 because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology,
      ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin
      cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal
      clearance, and Alzheimer-relevant amyloid-beta/tau handling.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0038023 (signaling receptor activity), the TAS annotation with qualifier
      enables from PMID:10880251 may reflect a real assay result or interaction, but
      this GO term does not identify the specific receptor, ligand-binding, cargo-clearance,
      endocytic, or localization annotation that explains LRP1's role in LDLR-family
      ligand binding and receptor-mediated internalization/clearance of lipoprotein,
      apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes.
      More informative gene-specific annotations are present, so this is marked over-annotated
      rather than accepted as a core function.
    additional_reference_ids:
    - file:human/LRP1/LRP1-notes.md
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with 
    GO terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to
    orthologs by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
    Location vocabulary mapping, accompanied by conservative changes to GO terms
    applied by UniProt
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000108
  title: Automatic assignment of GO terms using logical inference, based on on 
    inter-ontology links
  findings: []
- id: GO_REF:0000111
  title: Gene Ontology annotations Inferred by Curator (IC) using at least one 
    Inferred by Sequence Similarity (ISS) annotation to support the inference
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning 
    models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10772929
  title: LDL receptor-related protein as a component of the midkine receptor.
  findings: []
- id: PMID:10880251
  title: Involvement of alpha-2-macroglobulin receptor in clearance of 
    interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages.
  findings: []
- id: PMID:11240025
  title: Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal
    murine microglia to fibrillar beta-amyloid.
  findings: []
- id: PMID:12888553
  title: The intracellular domain of the low density lipoprotein 
    receptor-related protein modulates transactivation mediated by amyloid 
    precursor protein and Fe65.
  findings: []
- id: PMID:14645246
  title: The low density lipoprotein receptor-related protein LRP is regulated 
    by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in 
    malignant cells.
  findings: []
- id: PMID:15182176
  title: Two apolipoprotein E mimetic peptides, ApoE(130-149) and 
    ApoE(141-155)2, bind to LRP1.
  findings: []
- id: PMID:17326667
  title: Apolipoprotein A-V interaction with members of the low density 
    lipoprotein receptor gene family.
  findings: []
- id: PMID:17360663
  title: HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that 
    promotes apoptosis in neurons and astrocytes.
  findings: []
  reference_review:
    relevance: LOW
    correctness: VERIFIED
    review_notes: NeuroAIDS paper supports LRP-containing 
      postsynaptic/NMDAR/nNOS complex formation but is infection/toxicity 
      context rather than core LRP1 function.
- id: PMID:17897319
  title: Integral and associated lysosomal membrane proteins.
  findings: []
- id: PMID:18635818
  title: Effects of six APOA5 variants, identified in patients with severe 
    hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor 
    binding.
  findings: []
- id: PMID:19098903
  title: SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain
    vascular cells.
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Full-text AD vascular paper supporting LRP-mediated 
      amyloid-beta cerebrovascular clearance.
- id: PMID:20005821
  title: Overexpression of low-density lipoprotein receptor in the brain 
    markedly inhibits amyloid deposition and increases extracellular A beta 
    clearance.
  findings: []
- id: PMID:20030366
  title: 'Decoding of lipoprotein-receptor interactions: properties of ligand binding
    modules governing interactions with apolipoprotein E.'
  findings: []
- id: PMID:20199584
  title: Complement receptor 3 (CD11b/CD18) is implicated in the elimination of 
    Ξ²-amyloid peptides.
  findings: []
- id: PMID:20472562
  title: Low density lipoprotein receptor-related protein-1 (LRP1) regulates 
    thrombospondin-2 (TSP2) enhancement of Notch3 signaling.
  findings: []
- id: PMID:21054788
  title: CD91 interacts with mannan-binding lectin (MBL) through the 
    MBL-associated serine protease-binding site.
  findings: []
- id: PMID:21289173
  title: Heparan sulphate proteoglycan and the low-density lipoprotein 
    receptor-related protein 1 constitute major pathways for neuronal 
    amyloid-beta uptake.
  findings: []
- id: PMID:21423176
  title: Analysis of the myosin-II-responsive focal adhesion proteome reveals a 
    role for Ξ²-Pix in negative regulation of focal adhesion maturation.
  findings: []
- id: PMID:21968187
  title: Phosphorylation of LRP1 regulates the interaction with Fe65.
  findings: []
- id: PMID:22293988
  title: Cellular prion protein participates in amyloid-Ξ² transcytosis across 
    the blood-brain barrier.
  findings: []
- id: PMID:22383525
  title: Low-density lipoprotein receptor represents an apolipoprotein 
    E-independent pathway of AΞ² uptake and degradation by astrocytes.
  findings: []
- id: PMID:22658674
  title: Insights into RNA biology from an atlas of mammalian mRNA-binding 
    proteins.
  findings: []
- id: PMID:23152628
  title: LRP1 in brain vascular smooth muscle cells mediates local clearance of 
    Alzheimer's amyloid-Ξ².
  findings: []
- id: PMID:23382219
  title: Structural basis for endosomal trafficking of diverse transmembrane 
    cargos by PX-FERM proteins.
  findings: []
- id: PMID:23386614
  title: Prion protein-mediated toxicity of amyloid-Ξ² oligomers requires lipid 
    rafts and the transmembrane LRP1.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: Full-text AD AΞ² oligomer paper supporting LRP1-dependent AΞ² 
      oligomer internalization/toxicity context.
- id: PMID:24284412
  title: Amyloid beta a4 precursor protein-binding family B member 1 (FE65) 
    interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and 
    sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding 
    proteins in the human brain.
  findings: []
- id: PMID:24305823
  title: Neuronal clearance of amyloid-Ξ² by endocytic receptor LRP1.
  findings: []
- id: PMID:26005850
  title: Central role for PICALM in amyloid-Ξ² blood-brain barrier transcytosis 
    and clearance.
  findings: []
- id: PMID:26142438
  title: Whole exome sequencing identifies LRP1 as a pathogenic gene in 
    autosomal recessive keratosis pilaris atrophicans.
  findings: []
- id: PMID:26590417
  title: Establishment and Dysfunction of the Blood-Brain Barrier.
  findings: []
- id: PMID:26781079
  title: Clearance of matrix metalloproteinase-9 is dependent on low-density 
    lipoprotein receptor-related protein-1 expression downregulated by 
    microRNA-205 in human abdominal aortic aneurysm.
  findings: []
- id: PMID:2779654
  title: The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding 
    protein.
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Primary paper supporting LRP as an apolipoprotein E-binding 
      cell-surface receptor.
- id: PMID:28514442
  title: Architecture of the human interactome defines protein communities and 
    disease networks.
  findings: []
- id: PMID:29547901
  title: Molecular partners of hNOT/ALG3, the human counterpart of the 
    Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct 
    cellular processes relevant to congenital disorders of glycosylation, 
    cancer, neurodegeneration and a variety of further pathologies.
  findings: []
- id: PMID:30280653
  title: 'Blood-Brain Barrier: From Physiology to Disease and Back.'
  findings: []
- id: PMID:31023188
  title: LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial 
    Hypertension That Is Reversed by PPARΞ³ Activation.
  findings: []
- id: PMID:31326693
  title: The dynamic uptake and release of SOD3 from intracellular stores in 
    macrophages modulates the inflammatory response.
  findings: []
  reference_review:
    relevance: LOW
    correctness: VERIFIED
    review_notes: Full-text macrophage SOD3 paper supports 
      inflammatory/endocytic ligand handling context, non-core for LRP1.
- id: PMID:3266596
  title: Surface location and high affinity for calcium of a 500-kd liver 
    membrane protein closely related to the LDL-receptor suggest a physiological
    role as lipoprotein receptor.
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Primary LDL receptor-related protein paper supporting 
      cell-surface localization, calcium binding, and recycling lipoprotein 
      receptor function.
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the 
    human interactome.
  findings: []
- id: PMID:41162706
  title: Multiple LDLRΒ family members act as entry receptors for yellow fever 
    virus.
  findings: []
- id: PMID:8626514
  title: Plasminogen activator inhibitor-1 and vitronectin promote the cellular 
    clearance of thrombin by low density lipoprotein receptor-related proteins 1
    and 2.
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Primary endocytosis paper supporting LRP1/LRP2-mediated 
      clearance of thrombin-PAI-1 complexes.
- id: Reactome:R-HSA-2168897
  title: LRP1 (CD91) binds Hemopexin:heme
  findings: []
- id: Reactome:R-HSA-2230983
  title: LRP1:Hemopexin:heme is endocytosed
  findings: []
- id: Reactome:R-HSA-2404131
  title: LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol
  findings: []
- id: Reactome:R-HSA-975634
  title: Retinoid metabolism and transport
  findings: []
- id: file:human/LRP1/LRP1-uniprot.txt
  title: UniProt text export for LRP1 (Q07954)
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Local UniProt record directly supports LRP1 endocytic receptor
      function, ligand classes, tau/MAPT receptor activity, localization, 
      subunit processing, and tissue expression.
- id: file:human/LRP1/LRP1-notes.md
  title: Manual LRP1 review notes
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: Manual notes document the deep-research timeout and summarize 
      cached UniProt, PANTHER, GOA, and publication evidence used for this 
      review.
core_functions:
- description: Multifunctional LDLR-family endocytic cargo/scavenger receptor 
    activity at the plasma membrane and coated pits, internalizing ligand 
    complexes through receptor-mediated endocytosis and trafficking them through
    early endosomes and lysosomal/catabolic pathways.
  supported_by:
  - reference_id: file:human/LRP1/LRP1-uniprot.txt
    supporting_text: Endocytic receptor involved in endocytosis
  - reference_id: PMID:3266596
    supporting_text: cell surface protein
  - reference_id: PMID:3266596
    supporting_text: recycling lipoprotein receptor
  - reference_id: PMID:8626514
    supporting_text: mediate the endocytosis of thrombin-PAI-1
  molecular_function:
    id: GO:0038024
    label: cargo receptor activity
  directly_involved_in:
  - id: GO:0006898
    label: receptor-mediated endocytosis
  - id: GO:0031623
    label: receptor internalization
  - id: GO:0006909
    label: phagocytosis
  - id: GO:1905167
    label: positive regulation of lysosomal protein catabolic process
  locations:
  - id: GO:0005886
    label: plasma membrane
  - id: GO:0005769
    label: early endosome
  - id: GO:0030666
    label: endocytic vesicle membrane
- description: Apolipoprotein/lipoprotein and calcium-dependent LDLR-family 
    ligand receptor function supporting chylomicron-remnant/lipoprotein 
    transport, lipid metabolism, cholesterol efflux, and reverse cholesterol 
    transport.
  supported_by:
  - reference_id: file:human/LRP1/LRP1-uniprot.txt
    supporting_text: Involved in the plasma clearance
  - reference_id: file:human/LRP1/LRP1-uniprot.txt
    supporting_text: chylomicron remnants
  - reference_id: PMID:2779654
    supporting_text: apo E receptor
  - reference_id: PMID:3266596
    supporting_text: strongly binds calcium
  molecular_function:
    id: GO:0030226
    label: apolipoprotein receptor activity
  directly_involved_in:
  - id: GO:0042953
    label: lipoprotein transport
  - id: GO:0032370
    label: positive regulation of lipid transport
  - id: GO:0010875
    label: positive regulation of cholesterol efflux
  - id: GO:1903064
    label: positive regulation of reverse cholesterol transport
  locations:
  - id: GO:0005886
    label: plasma membrane
  - id: GO:0016323
    label: basolateral plasma membrane
- description: Alzheimer-relevant amyloid-beta binding, clearance, and 
    transcytosis across vascular or cellular barriers, with UniProt-supported 
    tau/MAPT receptor activity controlling tau endocytosis and spread as a 
    related disease-relevant cargo branch.
  supported_by:
  - reference_id: PMID:19098903
    supporting_text: key Abeta clearance receptor
  - reference_id: PMID:19098903
    supporting_text: controlling Abeta cerebrovascular clearance
  - reference_id: file:human/LRP1/LRP1-uniprot.txt
    supporting_text: TAU/MAPT receptor
  - reference_id: file:human/LRP1/LRP1-uniprot.txt
    supporting_text: endocytosis of TAU/MAPT
  molecular_function:
    id: GO:0001540
    label: amyloid-beta binding
  directly_involved_in:
  - id: GO:0097242
    label: amyloid-beta clearance
  - id: GO:0150094
    label: amyloid-beta clearance by cellular catabolic process
  - id: GO:0150093
    label: amyloid-beta clearance by transcytosis
  - id: GO:0150104
    label: transport across blood-brain barrier
  locations:
  - id: GO:0005886
    label: plasma membrane
  - id: GO:0016323
    label: basolateral plasma membrane
  - id: GO:0005769
    label: early endosome
proposed_new_terms: []
suggested_questions:
- question: Which Alzheimer-relevant LRP1 effects are mediated by direct 
    amyloid-beta/tau uptake versus indirect APOE/lipoprotein, vascular, or 
    inflammatory pathways?
- question: Can tau/MAPT receptor activity and tau transcytosis/spread be 
    represented with more specific GO terms than the current LRP1 GOA annotation
    set provides?
- question: 'Which LRP1 ligand classes should be prioritized as core in brain cell
    types: APOE lipoproteins, amyloid-beta species, tau, protease-inhibitor complexes,
    or extracellular-matrix-associated ligands?'
suggested_experiments:
- hypothesis: LRP1 Alzheimer risk biology depends on cell-type-specific handling
    of amyloid-beta and tau cargo at vascular and glial barriers.
  description: Perturb LRP1 in human iPSC-derived endothelial cells, pericytes, 
    astrocytes, microglia, and neurons, then separately measure APOE-lipoprotein
    uptake, amyloid-beta binding/clearance/transcytosis, tau uptake/spread, 
    endosomal routing, and lysosomal degradation.
  experiment_type: cell-type-specific receptor-cargo trafficking assay
- hypothesis: The LRP1 intracellular domain and adaptor-binding motifs tune 
    cargo endocytosis versus signaling outputs.
  description: Use endogenous motif-edited LRP1 constructs affecting 
    NPXY/adaptor binding and regulated intramembrane cleavage to compare 
    receptor internalization, cargo-specific uptake, intracellular-domain 
    nuclear/cytoplasmic signaling, and downstream inflammatory or ECM responses.
  experiment_type: endogenous receptor motif rescue assay