LRP1 encodes low-density lipoprotein receptor-related protein 1, a large LDL receptor-family type I membrane receptor that is proteolytically processed into extracellular ligand-binding and membrane/cytoplasmic subunits. LRP1 acts as a multifunctional endocytic, cargo, scavenger, apolipoprotein/lipoprotein, and alpha-2-macroglobulin receptor, concentrating ligands at the plasma membrane and clathrin-coated pits for receptor-mediated internalization, endosomal trafficking, lysosomal clearance, phagocytosis, and lipid transport. In Alzheimer-relevant biology, LRP1 participates in amyloid-beta binding, clearance, and transcytosis across vascular and cellular barriers, and UniProt also describes it as a tau/MAPT receptor controlling tau endocytosis and spread.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005886 (plasma membrane), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006898 receptor-mediated endocytosis | IBA GO_REF:0000033 | ACCEPT | Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006898 (receptor-mediated endocytosis), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006909 phagocytosis | IBA GO_REF:0000033 | ACCEPT | Summary: phagocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006909 (phagocytosis), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0034185 apolipoprotein binding | IBA GO_REF:0000033 | ACCEPT | Summary: apolipoprotein binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0034185 (apolipoprotein binding), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0038024 cargo receptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0038024 (cargo receptor activity), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150093 amyloid-beta clearance by transcytosis | IBA GO_REF:0000033 | ACCEPT | Summary: amyloid-beta clearance by transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150093 (amyloid-beta clearance by transcytosis), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150094 amyloid-beta clearance by cellular catabolic process | IBA GO_REF:0000033 | ACCEPT | Summary: amyloid-beta clearance by cellular catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0001523 retinoid metabolic process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: retinoid metabolic process is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0001523 (retinoid metabolic process), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005041 low-density lipoprotein particle receptor activity | IEA GO_REF:0000117 | ACCEPT | Summary: low-density lipoprotein particle receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005041 (low-density lipoprotein particle receptor activity), the IEA annotation with qualifier enables from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005509 calcium ion binding | IEA GO_REF:0000002 | ACCEPT | Summary: calcium ion binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005509 (calcium ion binding), the IEA annotation with qualifier enables from GO_REF:0000002 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: nucleus is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005634 (nucleus), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005737 (cytoplasm), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005769 early endosome | IEA GO_REF:0000117 | ACCEPT | Summary: early endosome is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005769 (early endosome), the IEA annotation with qualifier located_in from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005815 microtubule organizing center | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: microtubule organizing center is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005815 (microtubule organizing center), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in from GO_REF:0000120 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006898 receptor-mediated endocytosis | IEA GO_REF:0000117 | ACCEPT | Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006898 (receptor-mediated endocytosis), the IEA annotation with qualifier involved_in from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0016020 membrane | IEA GO_REF:0000044 | ACCEPT | Summary: membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0016020 (membrane), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030100 regulation of endocytosis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: regulation of endocytosis is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0030100 (regulation of endocytosis), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032050 clathrin heavy chain binding | IEA GO_REF:0000117 | ACCEPT | Summary: clathrin heavy chain binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0032050 (clathrin heavy chain binding), the IEA annotation with qualifier enables from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0044877 protein-containing complex binding | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: protein-containing complex binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0044877 (protein-containing complex binding), the IEA annotation with qualifier enables from GO_REF:0000117 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0046718 symbiont entry into host cell | IEA GO_REF:0000108 | KEEP AS NON CORE | Summary: symbiont entry into host cell is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0046718 (symbiont entry into host cell), the IEA annotation with qualifier involved_in from GO_REF:0000108 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0051050 positive regulation of transport | IEA GO_REF:0000117 | ACCEPT | Summary: positive regulation of transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0051050 (positive regulation of transport), the IEA annotation with qualifier involved_in from GO_REF:0000117 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0051246 regulation of protein metabolic process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: regulation of protein metabolic process is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0051246 (regulation of protein metabolic process), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:15182176 Two apolipoprotein E mimetic peptides, ApoE(130-149) and Apo... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15182176 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17326667 Apolipoprotein A-V interaction with members of the low densi... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17326667 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17360663 HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS compl... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17360663 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:20030366 Decoding of lipoprotein-receptor interactions: properties of... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20030366 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:20472562 Low density lipoprotein receptor-related protein-1 (LRP1) re... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20472562 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21054788 CD91 interacts with mannan-binding lectin (MBL) through the ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21054788 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21968187 Phosphorylation of LRP1 regulates the interaction with Fe65. | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21968187 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:24284412 Amyloid beta a4 precursor protein-binding family B member 1 ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24284412 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28514442 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:29547901 Molecular partners of hNOT/ALG3, the human counterpart of th... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:29547901 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:33961781 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0002673 regulation of acute inflammatory response | IDA PMID:31326693 The dynamic uptake and release of SOD3 from intracellular st... | KEEP AS NON CORE | Summary: regulation of acute inflammatory response is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0002673 (regulation of acute inflammatory response), the IDA annotation with qualifier involved_in from PMID:31326693 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0038024 cargo receptor activity | IDA PMID:31326693 The dynamic uptake and release of SOD3 from intracellular st... | ACCEPT | Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0038024 (cargo receptor activity), the IDA annotation with qualifier enables from PMID:31326693 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0001523 retinoid metabolic process | TAS Reactome:R-HSA-975634 | KEEP AS NON CORE | Summary: retinoid metabolic process is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0001523 (retinoid metabolic process), the TAS annotation with qualifier involved_in from Reactome:R-HSA-975634 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005730 nucleolus | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: nucleolus is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005730 (nucleolus), the IDA annotation with qualifier located_in from GO_REF:0000052 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: cytosol is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005829 (cytosol), the IDA annotation with qualifier located_in from GO_REF:0000052 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from GO_REF:0000052 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0001618 virus receptor activity | IMP PMID:41162706 Multiple LDLRΒ family members act as entry receptors for yell... | KEEP AS NON CORE | Summary: virus receptor activity is retained as a non-core molecular-function annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0001618 (virus receptor activity), the IMP annotation with qualifier enables from PMID:41162706 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005634 nucleus | EXP PMID:12888553 The intracellular domain of the low density lipoprotein rece... | KEEP AS NON CORE | Summary: nucleus is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005634 (nucleus), the EXP annotation with qualifier located_in from PMID:12888553 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005737 cytoplasm | EXP PMID:12888553 The intracellular domain of the low density lipoprotein rece... | KEEP AS NON CORE | Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:12888553 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0150051 postsynaptic Golgi apparatus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: postsynaptic Golgi apparatus is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150051 (postsynaptic Golgi apparatus), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1903064 positive regulation of reverse cholesterol transport | ISS GO_REF:0000024 | ACCEPT | Summary: positive regulation of reverse cholesterol transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:1903064 (positive regulation of reverse cholesterol transport), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006898 receptor-mediated endocytosis | IMP PMID:26781079 Clearance of matrix metalloproteinase-9 is dependent on low-... | ACCEPT | Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier involved_in from PMID:26781079 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1903053 regulation of extracellular matrix organization | IMP PMID:26781079 Clearance of matrix metalloproteinase-9 is dependent on low-... | KEEP AS NON CORE | Summary: regulation of extracellular matrix organization is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:1903053 (regulation of extracellular matrix organization), the IMP annotation with qualifier acts_upstream_of from PMID:26781079 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0060392 negative regulation of SMAD protein signal transduction | ISS PMID:31023188 LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial ... | KEEP AS NON CORE | Summary: negative regulation of SMAD protein signal transduction is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0060392 (negative regulation of SMAD protein signal transduction), the ISS annotation with qualifier involved_in from PMID:31023188 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0007167 enzyme-linked receptor protein signaling pathway | ISS PMID:31023188 LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial ... | KEEP AS NON CORE | Summary: enzyme-linked receptor protein signaling pathway is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0007167 (enzyme-linked receptor protein signaling pathway), the ISS annotation with qualifier involved_in from PMID:31023188 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010629 negative regulation of gene expression | ISS PMID:31023188 LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial ... | KEEP AS NON CORE | Summary: negative regulation of gene expression is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0010629 (negative regulation of gene expression), the ISS annotation with qualifier involved_in from PMID:31023188 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005041 low-density lipoprotein particle receptor activity | TAS Reactome:R-HSA-2404131 | ACCEPT | Summary: low-density lipoprotein particle receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005041 (low-density lipoprotein particle receptor activity), the TAS annotation with qualifier enables from Reactome:R-HSA-2404131 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006629 lipid metabolic process | TAS PMID:21289173 Heparan sulphate proteoglycan and the low-density lipoprotei... | ACCEPT | Summary: lipid metabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006629 (lipid metabolic process), the TAS annotation with qualifier involved_in from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0043395 heparan sulfate proteoglycan binding | TAS PMID:21289173 Heparan sulphate proteoglycan and the low-density lipoprotei... | ACCEPT | Summary: heparan sulfate proteoglycan binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0043395 (heparan sulfate proteoglycan binding), the TAS annotation with qualifier enables from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150104 transport across blood-brain barrier | NAS PMID:30280653 Blood-Brain Barrier: From Physiology to Disease and Back. | ACCEPT | Summary: transport across blood-brain barrier is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150104 (transport across blood-brain barrier), the NAS annotation with qualifier involved_in from PMID:30280653 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150104 transport across blood-brain barrier | NAS PMID:26590417 Establishment and Dysfunction of the Blood-Brain Barrier. | ACCEPT | Summary: transport across blood-brain barrier is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150104 (transport across blood-brain barrier), the NAS annotation with qualifier involved_in from PMID:26590417 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:26005850 Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26005850 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0032050 clathrin heavy chain binding | IPI PMID:26005850 Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... | ACCEPT | Summary: clathrin heavy chain binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0032050 (clathrin heavy chain binding), the IPI annotation with qualifier enables from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150093 amyloid-beta clearance by transcytosis | ISS GO_REF:0000024 | ACCEPT | Summary: amyloid-beta clearance by transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150093 (amyloid-beta clearance by transcytosis), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150104 transport across blood-brain barrier | ISS GO_REF:0000024 | ACCEPT | Summary: transport across blood-brain barrier is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150104 (transport across blood-brain barrier), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1900223 positive regulation of amyloid-beta clearance | ISS GO_REF:0000024 | ACCEPT | Summary: positive regulation of amyloid-beta clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:1900223 (positive regulation of amyloid-beta clearance), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1904300 positive regulation of transcytosis | ISS GO_REF:0000024 | ACCEPT | Summary: positive regulation of transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:1904300 (positive regulation of transcytosis), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0038024 cargo receptor activity | NAS PMID:3266596 Surface location and high affinity for calcium of a 500-kd l... | ACCEPT | Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0038024 (cargo receptor activity), the NAS annotation with qualifier enables from PMID:3266596 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:10772929 LDL receptor-related protein as a component of the midkine r... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:10772929 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0007041 lysosomal transport | ISS GO_REF:0000024 | ACCEPT | Summary: lysosomal transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0007041 (lysosomal transport), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0001540 amyloid-beta binding | IC GO_REF:0000111 | ACCEPT | Summary: amyloid-beta binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0001540 (amyloid-beta binding), the IC annotation with qualifier enables from GO_REF:0000111 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0002265 astrocyte activation involved in immune response | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: astrocyte activation involved in immune response is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0002265 (astrocyte activation involved in immune response), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0006898 receptor-mediated endocytosis | ISS GO_REF:0000024 | ACCEPT | Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006898 (receptor-mediated endocytosis), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006898 receptor-mediated endocytosis | IMP PMID:23152628 LRP1 in brain vascular smooth muscle cells mediates local cl... | ACCEPT | Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006898 receptor-mediated endocytosis | IMP PMID:24305823 Neuronal clearance of amyloid-Ξ² by endocytic receptor LRP1. | ACCEPT | Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier involved_in from PMID:24305823 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006898 receptor-mediated endocytosis | IMP PMID:26005850 Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... | ACCEPT | Summary: receptor-mediated endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006898 (receptor-mediated endocytosis), the IMP annotation with qualifier involved_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006909 phagocytosis | IMP PMID:23152628 LRP1 in brain vascular smooth muscle cells mediates local cl... | ACCEPT | Summary: phagocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006909 (phagocytosis), the IMP annotation with qualifier involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0038024 cargo receptor activity | ISS GO_REF:0000024 | ACCEPT | Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0038024 (cargo receptor activity), the ISS annotation with qualifier enables from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0038024 cargo receptor activity | IMP PMID:23152628 LRP1 in brain vascular smooth muscle cells mediates local cl... | ACCEPT | Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0038024 (cargo receptor activity), the IMP annotation with qualifier enables from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0038024 cargo receptor activity | IMP PMID:24305823 Neuronal clearance of amyloid-Ξ² by endocytic receptor LRP1. | ACCEPT | Summary: cargo receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0038024 (cargo receptor activity), the IMP annotation with qualifier enables from PMID:24305823 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150093 amyloid-beta clearance by transcytosis | IGI PMID:26005850 Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... | ACCEPT | Summary: amyloid-beta clearance by transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150093 (amyloid-beta clearance by transcytosis), the IGI annotation with qualifier involved_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150094 amyloid-beta clearance by cellular catabolic process | ISS GO_REF:0000024 | ACCEPT | Summary: amyloid-beta clearance by cellular catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150094 amyloid-beta clearance by cellular catabolic process | IMP PMID:23152628 LRP1 in brain vascular smooth muscle cells mediates local cl... | ACCEPT | Summary: amyloid-beta clearance by cellular catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IMP annotation with qualifier involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0150094 amyloid-beta clearance by cellular catabolic process | IMP PMID:24305823 Neuronal clearance of amyloid-Ξ² by endocytic receptor LRP1. | ACCEPT | Summary: amyloid-beta clearance by cellular catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0150094 (amyloid-beta clearance by cellular catabolic process), the IMP annotation with qualifier involved_in from PMID:24305823 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1904646 cellular response to amyloid-beta | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: cellular response to amyloid-beta is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:1904646 (cellular response to amyloid-beta), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1905167 positive regulation of lysosomal protein catabolic process | IMP PMID:23152628 LRP1 in brain vascular smooth muscle cells mediates local cl... | ACCEPT | Summary: positive regulation of lysosomal protein catabolic process is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:1905167 (positive regulation of lysosomal protein catabolic process), the IMP annotation with qualifier involved_in from PMID:23152628 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1903078 positive regulation of protein localization to plasma membrane | IGI PMID:23386614 Prion protein-mediated toxicity of amyloid-Ξ² oligomers requi... | KEEP AS NON CORE | Summary: positive regulation of protein localization to plasma membrane is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:1903078 (positive regulation of protein localization to plasma membrane), the IGI annotation with qualifier involved_in from PMID:23386614 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0045807 positive regulation of endocytosis | IGI PMID:23386614 Prion protein-mediated toxicity of amyloid-Ξ² oligomers requi... | ACCEPT | Summary: positive regulation of endocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0045807 (positive regulation of endocytosis), the IGI annotation with qualifier involved_in from PMID:23386614 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006909 phagocytosis | NAS PMID:20199584 Complement receptor 3 (CD11b/CD18) is implicated in the elim... | ACCEPT | Summary: phagocytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0006909 (phagocytosis), the NAS annotation with qualifier involved_in from PMID:20199584 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0097242 amyloid-beta clearance | NAS PMID:20199584 Complement receptor 3 (CD11b/CD18) is implicated in the elim... | ACCEPT | Summary: amyloid-beta clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0097242 (amyloid-beta clearance), the NAS annotation with qualifier involved_in from PMID:20199584 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1900223 positive regulation of amyloid-beta clearance | TAS PMID:22383525 Low-density lipoprotein receptor represents an apolipoprotei... | ACCEPT | Summary: positive regulation of amyloid-beta clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:1900223 (positive regulation of amyloid-beta clearance), the TAS annotation with qualifier involved_in from PMID:22383525 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005041 low-density lipoprotein particle receptor activity | TAS PMID:20005821 Overexpression of low-density lipoprotein receptor in the br... | ACCEPT | Summary: low-density lipoprotein particle receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005041 (low-density lipoprotein particle receptor activity), the TAS annotation with qualifier enables from PMID:20005821 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005044 scavenger receptor activity | TAS PMID:11240025 Scavenger receptor class B type I (SR-BI) mediates adhesion ... | ACCEPT | Summary: scavenger receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005044 (scavenger receptor activity), the TAS annotation with qualifier enables from PMID:11240025 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005769 early endosome | IDA PMID:26005850 Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... | ACCEPT | Summary: early endosome is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005769 (early endosome), the IDA annotation with qualifier located_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0016323 basolateral plasma membrane | IDA PMID:26005850 Central role for PICALM in amyloid-Ξ² blood-brain barrier tra... | ACCEPT | Summary: basolateral plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0016323 (basolateral plasma membrane), the IDA annotation with qualifier located_in from PMID:26005850 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0016964 alpha-2 macroglobulin receptor activity | TAS PMID:21289173 Heparan sulphate proteoglycan and the low-density lipoprotei... | ACCEPT | Summary: alpha-2 macroglobulin receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0016964 (alpha-2 macroglobulin receptor activity), the TAS annotation with qualifier enables from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030226 apolipoprotein receptor activity | TAS PMID:21289173 Heparan sulphate proteoglycan and the low-density lipoprotei... | ACCEPT | Summary: apolipoprotein receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0030226 (apolipoprotein receptor activity), the TAS annotation with qualifier enables from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0098797 plasma membrane protein complex | TAS PMID:21289173 Heparan sulphate proteoglycan and the low-density lipoprotei... | ACCEPT | Summary: plasma membrane protein complex is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0098797 (plasma membrane protein complex), the TAS annotation with qualifier part_of from PMID:21289173 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0016964 alpha-2 macroglobulin receptor activity | IMP PMID:26142438 Whole exome sequencing identifies LRP1 as a pathogenic gene ... | ACCEPT | Summary: alpha-2 macroglobulin receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0016964 (alpha-2 macroglobulin receptor activity), the IMP annotation with qualifier enables from PMID:26142438 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031623 receptor internalization | TAS PMID:22293988 Cellular prion protein participates in amyloid-Ξ² transcytosi... | ACCEPT | Summary: receptor internalization is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0031623 (receptor internalization), the TAS annotation with qualifier involved_in from PMID:22293988 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0045056 transcytosis | TAS PMID:22293988 Cellular prion protein participates in amyloid-Ξ² transcytosi... | ACCEPT | Summary: transcytosis is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0045056 (transcytosis), the TAS annotation with qualifier involved_in from PMID:22293988 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0016020 membrane | NAS PMID:23386614 Prion protein-mediated toxicity of amyloid-Ξ² oligomers requi... | ACCEPT | Summary: membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0016020 (membrane), the NAS annotation with qualifier located_in from PMID:23386614 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | TAS PMID:14645246 The low density lipoprotein receptor-related protein LRP is ... | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from PMID:14645246 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0010715 regulation of extracellular matrix disassembly | TAS PMID:14645246 The low density lipoprotein receptor-related protein LRP is ... | KEEP AS NON CORE | Summary: regulation of extracellular matrix disassembly is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0010715 (regulation of extracellular matrix disassembly), the TAS annotation with qualifier involved_in from PMID:14645246 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:8626514 Plasminogen activator inhibitor-1 and vitronectin promote th... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:8626514 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005925 focal adhesion | HDA PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome... | KEEP AS NON CORE | Summary: focal adhesion is retained as a non-core cellular-component/localization annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005925 (focal adhesion), the HDA annotation with qualifier located_in from PMID:21423176 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0003723 RNA binding | HDA PMID:22658674 Insights into RNA biology from an atlas of mammalian mRNA-bi... | MARK AS OVER ANNOTATED | Summary: RNA binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0003723 (RNA binding), the HDA annotation with qualifier enables from PMID:22658674 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0043235 signaling receptor complex | IDA PMID:23382219 Structural basis for endosomal trafficking of diverse transm... | ACCEPT | Summary: signaling receptor complex is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0043235 (signaling receptor complex), the IDA annotation with qualifier part_of from PMID:23382219 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005765 lysosomal membrane | HDA PMID:17897319 Integral and associated lysosomal membrane proteins. | ACCEPT | Summary: lysosomal membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005765 (lysosomal membrane), the HDA annotation with qualifier located_in from PMID:17897319 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2168897 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from Reactome:R-HSA-2168897 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2230983 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from Reactome:R-HSA-2230983 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2404131 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from Reactome:R-HSA-2404131 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030666 endocytic vesicle membrane | TAS Reactome:R-HSA-2230983 | ACCEPT | Summary: endocytic vesicle membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0030666 (endocytic vesicle membrane), the TAS annotation with qualifier located_in from Reactome:R-HSA-2230983 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0097242 amyloid-beta clearance | TAS PMID:19098903 SRF and myocardin regulate LRP-mediated amyloid-beta clearan... | ACCEPT | Summary: amyloid-beta clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0097242 (amyloid-beta clearance), the TAS annotation with qualifier involved_in from PMID:19098903 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0014912 negative regulation of smooth muscle cell migration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of smooth muscle cell migration is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0014912 (negative regulation of smooth muscle cell migration), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032956 regulation of actin cytoskeleton organization | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulation of actin cytoskeleton organization is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0032956 (regulation of actin cytoskeleton organization), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0035909 aorta morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: aorta morphogenesis is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0035909 (aorta morphogenesis), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of platelet-derived growth factor receptor-beta signaling pathway is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:2000587 (negative regulation of platelet-derived growth factor receptor-beta signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005509 calcium ion binding | ISS GO_REF:0000024 | ACCEPT | Summary: calcium ion binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005509 (calcium ion binding), the ISS annotation with qualifier enables from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0005886 (plasma membrane), the ISS annotation with qualifier located_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0034185 apolipoprotein binding | IDA PMID:2779654 The LDL-receptor-related protein, LRP, is an apolipoprotein ... | ACCEPT | Summary: apolipoprotein binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0034185 (apolipoprotein binding), the IDA annotation with qualifier enables from PMID:2779654 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0042953 lipoprotein transport | NAS PMID:3266596 Surface location and high affinity for calcium of a 500-kd l... | ACCEPT | Summary: lipoprotein transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0042953 (lipoprotein transport), the NAS annotation with qualifier involved_in from PMID:3266596 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0044877 protein-containing complex binding | IDA PMID:8626514 Plasminogen activator inhibitor-1 and vitronectin promote th... | MARK AS OVER ANNOTATED | Summary: protein-containing complex binding is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0044877 (protein-containing complex binding), the IDA annotation with qualifier enables from PMID:8626514 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0010875 positive regulation of cholesterol efflux | ISS GO_REF:0000024 | ACCEPT | Summary: positive regulation of cholesterol efflux is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0010875 (positive regulation of cholesterol efflux), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030178 negative regulation of Wnt signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of Wnt signaling pathway is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0030178 (negative regulation of Wnt signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal LRP1 function: LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032370 positive regulation of lipid transport | ISS GO_REF:0000024 | ACCEPT | Summary: positive regulation of lipid transport is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0032370 (positive regulation of lipid transport), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0043277 apoptotic cell clearance | ISS GO_REF:0000024 | ACCEPT | Summary: apoptotic cell clearance is retained as a core biological-process annotation for LRP1; it captures process participation within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0043277 (apoptotic cell clearance), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0034185 apolipoprotein binding | IPI PMID:18635818 Effects of six APOA5 variants, identified in patients with s... | ACCEPT | Summary: apolipoprotein binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0034185 (apolipoprotein binding), the IPI annotation with qualifier enables from PMID:18635818 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0070325 lipoprotein particle receptor binding | IC PMID:18635818 Effects of six APOA5 variants, identified in patients with s... | ACCEPT | Summary: lipoprotein particle receptor binding is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0070325 (lipoprotein particle receptor binding), the IC annotation with qualifier enables from PMID:18635818 is consistent with LRP1's core role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. This action keeps the term because it provides a specific, evidence-backed receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0038023 signaling receptor activity | TAS PMID:10880251 Involvement of alpha-2-macroglobulin receptor in clearance o... | MARK AS OVER ANNOTATED | Summary: signaling receptor activity is marked over-annotated for LRP1 because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling. Reason: For GO:0038023 (signaling receptor activity), the TAS annotation with qualifier enables from PMID:10880251 may reflect a real assay result or interaction, but this GO term does not identify the specific receptor, ligand-binding, cargo-clearance, endocytic, or localization annotation that explains LRP1's role in LDLR-family ligand binding and receptor-mediated internalization/clearance of lipoprotein, apolipoprotein, protease-inhibitor, amyloid-beta, tau, and other cargo complexes. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
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Download this section (compressed HTML)Q: Which Alzheimer-relevant LRP1 effects are mediated by direct amyloid-beta/tau uptake versus indirect APOE/lipoprotein, vascular, or inflammatory pathways?
Q: Can tau/MAPT receptor activity and tau transcytosis/spread be represented with more specific GO terms than the current LRP1 GOA annotation set provides?
Q: Which LRP1 ligand classes should be prioritized as core in brain cell types: APOE lipoproteins, amyloid-beta species, tau, protease-inhibitor complexes, or extracellular-matrix-associated ligands?
Experiment: Perturb LRP1 in human iPSC-derived endothelial cells, pericytes, astrocytes, microglia, and neurons, then separately measure APOE-lipoprotein uptake, amyloid-beta binding/clearance/transcytosis, tau uptake/spread, endosomal routing, and lysosomal degradation.
Hypothesis: LRP1 Alzheimer risk biology depends on cell-type-specific handling of amyloid-beta and tau cargo at vascular and glial barriers.
Type: cell-type-specific receptor-cargo trafficking assay
Experiment: Use endogenous motif-edited LRP1 constructs affecting NPXY/adaptor binding and regulated intramembrane cleavage to compare receptor internalization, cargo-specific uptake, intracellular-domain nuclear/cytoplasmic signaling, and downstream inflammatory or ECM responses.
Hypothesis: The LRP1 intracellular domain and adaptor-binding motifs tune cargo endocytosis versus signaling outputs.
Type: endogenous receptor motif rescue assay
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