LYN is a cytoplasmic (non-receptor) protein-tyrosine kinase of the Src family (EC 2.7.10.2), expressed mainly in B-lymphoid, myeloid, mast, platelet and erythroid lineages, with two splice isoforms (p56/LynA and p53/LynB). It has the canonical Src architecture: an N-terminal SH4 region that is N-myristoylated at Gly2 and S-palmitoylated at Cys3, a unique region, SH3 and SH2 domains, a tyrosine-kinase domain, and a C-terminal regulatory tail. Lipidation anchors LYN to the cytoplasmic face of the plasma membrane and enriches it in cholesterol/sphingolipid rafts, where it carries out its principal function; newly synthesized LYN traffics through the Golgi, and a secondary nuclear pool participates in the genotoxic-stress response. LYN catalyses ATP-dependent phosphorylation of tyrosine residues in protein substrates and is autoinhibited by an intramolecular SH2-clamp onto C-terminal phospho-Tyr508 (added by CSK/CHK); activation-loop Tyr397 autophosphorylation and CD45-mediated dephosphorylation of Tyr508 promote the active state. Functionally, LYN is a receptor-proximal signalling switch acting downstream of immunoreceptors (the B-cell receptor via CD79A/CD79B, FcepsilonRI, FcgammaR, CD19, CD22) and of cytokine and growth-factor receptors (KIT, EPOR, MPL, CSF2RB, CXCR4). It phosphorylates activating ITAM motifs to create docking sites for SYK and propagate signalling (PI3K-AKT, BTK-PLCgamma, calcium, MAPK), and it phosphorylates inhibitory ITIM motifs of co-receptors (CD22, FcgammaRIIB, PIR-B, SIRPA) to recruit the phosphatases SHP-1, SHP-2 and SHIP-1, thereby restraining signalling. This dual activating/inhibitory role makes LYN both an initiator and a terminator of immune-cell signalling and a key enforcer of immune self-tolerance; gain-of-function variants that abolish Tyr508 regulation cause a constitutively active-kinase autoinflammatory vasculitis and liver-fibrosis syndrome.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000077 DNA damage checkpoint signaling | IDA PMID:10891478 Role for Lyn tyrosine kinase as a regulator of stress-activa... | KEEP AS NON CORE | Summary: DNA damage checkpoint / genotoxic-stress signaling. Reason: LYN is activated by DNA damage and contributes to the genotoxic-stress signaling/apoptosis response (PMID:10891478, PMID:11517336). A real but non-core, context-specific role secondary to its immunoreceptor function. Supporting Evidence: PMID:10891478 The cellular response to DNA damage includes activation of the nuclear Lyn protein tyrosine kinase. |
| GO:0001782 B cell homeostasis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: B cell homeostasis. Reason: LYN regulates B-cell survival/tolerance thresholds (dual activating/inhibitory role); an important but downstream, non-core physiological outcome of its kinase function. |
| GO:0001817 regulation of cytokine production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of cytokine production. Reason: Downstream consequence of LYN-dependent immune-receptor signaling; non-core. |
| GO:0001932 regulation of protein phosphorylation | TAS PMID:15489917 Src-family kinases in B-cell development and signaling. | KEEP AS NON CORE | Summary: Regulation of protein phosphorylation. Reason: The LYN review PMID:15489917 describes both phosphorylation of activating receptor motifs and recruitment of inhibitory phosphatases. Protein-phosphorylation regulation therefore includes control of other enzymes as well as LYN catalysis; retain this regulatory function without equating it solely with its own catalytic reaction. |
| GO:0001933 negative regulation of protein phosphorylation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of protein phosphorylation. Reason: Reflects LYN's inhibitory arm - phosphorylating ITIMs to recruit phosphatases that dephosphorylate signaling kinases. Real but non-core at the process level. |
| GO:0002223 stimulatory C-type lectin receptor signaling pathway | TAS Reactome:R-HSA-5621481 | KEEP AS NON CORE | Summary: Stimulatory C-type lectin receptor signaling pathway. Reason: LYN phosphorylates FcRgamma associated with CLEC receptors (Reactome); a genuine but non-core immunoreceptor branch. |
| GO:0002244 hematopoietic progenitor cell differentiation | IMP PMID:16467205 Integrin inhibition through Lyn-dependent cross talk from CX... | MARK AS OVER ANNOTATED | Summary: The study measures Lyn-dependent progenitor migration and adhesion, not differentiation itself. Reason: The full text shows Lyn ablation impairs CXCR4/SDF-1-mediated migration and adhesion of hematopoietic precursors, with differentiation mentioned only as the developmental context during which progenitor homing occurs; the paper demonstrates no differentiation phenotype, so assigning the gene to hematopoietic progenitor cell differentiation over-annotates a migration and adhesion study. Supporting Evidence: PMID:16467205 The data presented here imply a Lyn-mediated mechanism that explains the ability of SDF-1 to promote the migration and homing of normal stem/progenitor cells to different niches within bone marrow during differentiation and maturation |
| GO:0002431 Fc receptor mediated stimulatory signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Fc receptor mediated stimulatory signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN phosphorylates activating Fc-receptor ITAMs to nucleate SYK-dependent signaling; this is a defining, direct deployment of its kinase activity. IBA node placement is consistent across Src-family kinases. |
| GO:0002431 Fc receptor mediated stimulatory signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Fc receptor mediated stimulatory signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN phosphorylates activating Fc-receptor ITAMs to nucleate SYK-dependent signaling; this is a defining, direct deployment of its kinase activity. IBA node placement is consistent across Src-family kinases. |
| GO:0002513 tolerance induction to self antigen | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Tolerance induction to self antigen. Reason: An important immunological outcome of LYN's inhibitory (ITIM/phosphatase) signaling, but a downstream process rather than a core molecular role; non-core. |
| GO:0002513 tolerance induction to self antigen | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Tolerance induction to self antigen. Reason: An important immunological outcome of LYN's inhibitory (ITIM/phosphatase) signaling, but a downstream process rather than a core molecular role; non-core. |
| GO:0002513 tolerance induction to self antigen | TAS PMID:15489917 Src-family kinases in B-cell development and signaling. | KEEP AS NON CORE | Summary: Tolerance induction to self antigen. Reason: An important immunological outcome of LYN's inhibitory (ITIM/phosphatase) signaling, but a downstream process rather than a core molecular role; non-core. |
| GO:0002553 histamine secretion by mast cell | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Histamine secretion by mast cell. Reason: Downstream mast-cell effector output of FcepsilonRI signaling in which LYN participates; non-core (electronic ortholog transfer). |
| GO:0002576 platelet degranulation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Platelet degranulation. Reason: Downstream platelet effector process; LYN acts in platelet GPVI/immunoreceptor signaling. Non-core. |
| GO:0002758 innate immune response-activating signaling pathway | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Innate immune response-activating signaling pathway. Reason: General innate-immune signaling role consistent with LYN's function in myeloid/TLR signaling; non-core at this level of granularity. |
| GO:0002768 immune response-regulating cell surface receptor signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Immune response-regulating cell surface receptor signaling pathway - the process most directly describing LYN's role. Reason: This process term precisely captures LYN's core biological deployment: transducing signals from immune cell-surface receptors (BCR, FcRs) by phosphorylating their ITAM/ITIM motifs. |
| GO:0002768 immune response-regulating cell surface receptor signaling pathway | TAS PMID:15489917 Src-family kinases in B-cell development and signaling. | ACCEPT | Summary: Immune response-regulating cell surface receptor signaling pathway - the process most directly describing LYN's role. Reason: This process term precisely captures LYN's core biological deployment: transducing signals from immune cell-surface receptors (BCR, FcRs) by phosphorylating their ITAM/ITIM motifs. |
| GO:0002774 Fc receptor mediated inhibitory signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Fc receptor mediated inhibitory signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN phosphorylates inhibitory Fc-receptor (e.g. FcgammaRIIB) ITIMs, recruiting SHP/SHIP phosphatases; this inhibitory arm is a defining, comparatively non-redundant LYN function. |
| GO:0002862 negative regulation of inflammatory response to antigenic stimulus | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Negative regulation of inflammatory response to antigenic stimulus. Reason: Downstream anti-inflammatory outcome of LYN's inhibitory signaling; non-core. |
| GO:0002862 negative regulation of inflammatory response to antigenic stimulus | TAS Reactome:R-HSA-9664323 | KEEP AS NON CORE | Summary: Negative regulation of inflammatory response to antigenic stimulus. Reason: Downstream anti-inflammatory outcome of LYN's inhibitory signaling; non-core. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:10861086 Differential involvement of Src family kinases in Fc gamma r... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. Reconstitution of macrophage Fc-receptor phagocytosis tests activated LYN/HCK rather than proving all Src-family kinases interchangeable. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:11110698 Fyn and Lyn phosphorylate the Fc receptor gamma chain downst... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. Mouse platelets reveal distinct activating and delayed inhibitory contributions of Lyn and Fyn. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:11358993 Protein kinase C theta is expressed in mast cells and is fun... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The mast-cell study tests PKCΞΈ-associated receptor signaling; the catalytic identity is independently established by direct LYN substrate assays. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:11448999 Vav2 is required for cell spreading. | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The accessible Vav2 study does not resolve every LYN-specific experiment; direct independent LYN kinase evidence supports the molecular claim. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:12670955 A lipid raft environment enhances Lyn kinase activity by pro... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The study distinguishes the kinase activity of raft-associated LYN from other cellular pools. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:12923167 Tyrosyl phosphorylation of Shp2 is required for normal ERK a... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The accessible receptor/SHP2 study does not expose every LYN-specific assay; catalytic activity is independently established. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:1381360 Steel factor stimulates the tyrosine phosphorylation of the ... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The accessible c-KIT/Vav abstract does not resolve the exact LYN assay; independent target biochemistry supports the molecular function. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:16921024 Differential kinase requirements in human and mouse Fc-gamma... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The Fc-receptor study distinguishes phagocytosis from endocytosis and uses Src-family perturbations. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:18697750 Gab2 is involved in differential phosphoinositide 3-kinase s... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The c-KIT/Gab2 setting tests receptor-specific signaling rather than a universal B-cell requirement. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:7526393 Transphosphorylation as the mechanism by which the high-affi... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. FcΞ΅RI transphosphorylation provides an immunoreceptor activation context. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:8064233 Physical and functional association of the high affinity imm... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. Human monocyte FcΞ³RI complexes contain LYN and show receptor-associated kinase activation. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:9799234 Kit signaling through PI 3-kinase and Src kinase pathways: a... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The native mast-cell KIT experiment addresses Src/PI3K/RacβJNK signaling. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:10748115 Substrate recognition by the Lyn protein-tyrosine kinase. NM... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The study characterizes recognition and phosphorylation of a CD79A ITAM peptide. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. IL-5 receptor association and eosinophil differentiation experiments establish a cytokine-receptor context. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:32958780 CD36 facilitates fatty acid uptake by dynamic palmitoylation... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7682714 Identification of HS1 protein as a major substrate of protei... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. HS1 interaction and phosphorylation demonstrate a hematopoietic substrate context. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:36122175 De Novo Gain-Of-Function Variations in LYN Associated With a... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:36932076 Constitutively active Lyn kinase causes a cutaneous small ve... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS PMID:3561390 The yes-related cellular gene lyn encodes a possible tyrosin... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The original sequence characterization is complemented by direct LYN kinase/substrate experiments. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-1433506 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-1472121 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-210291 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-2730862 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-388831 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-388833 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-5624486 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-5690702 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9664261 | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine protein tyrosine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The conserved domain/experimental assignment agrees with direct target kinase biochemistry. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN. Reason: LYN is a cytoplasmic (non-receptor) Src-family tyrosine kinase. This is the correct, most specific MF term and represents the gene's core function. The IBA node includes P07948 itself among the descendants that ground the ancestral assertion, which is expected experimental support, not circularity. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000003 | ACCEPT | Summary: Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN. Reason: LYN is a cytoplasmic (non-receptor) Src-family tyrosine kinase. This is the correct, most specific MF term and represents the gene's core function. The IBA node includes P07948 itself among the descendants that ground the ancestral assertion, which is expected experimental support, not circularity. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IMP PMID:23555801 BANK1 and BLK act through phospholipase C gamma 2 in B-cell ... | ACCEPT | Summary: Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN. Reason: LYN is a non-receptor Src-family tyrosine kinase. PMID:23555801 uses LYN constructs and discusses its BANK1/IP3R context, while its principal new activation experiments concern BLK. Retention of the LYN catalytic function also rests on independent biochemical characterization, not on relabeling the BLK result as a LYN assay. Supporting Evidence: PMID:23555801 Although the phosphorylation of BANK1 does not require LYN, the phosphorylation of BANK1 enhances binding to LYN and promotes tyrosine phosphorylation of IP3R2 leading to release of calcium from intracellular stores [11]. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-1168459 | ACCEPT | Summary: Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN. Reason: LYN is a cytoplasmic (non-receptor) Src-family tyrosine kinase. This is the correct, most specific MF term and represents the gene's core function. The IBA node includes P07948 itself among the descendants that ground the ancestral assertion, which is expected experimental support, not circularity. |
| GO:0005102 signaling receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: Signaling receptor binding - LYN docks onto immunoreceptors and cytokine/growth-factor receptors. Reason: LYN binds and phosphorylates immunoreceptors and receptor subunits (CD79A/B, CD22, FcR subunits, KIT, EPOR, CSF2RB) via its SH2/SH3 domains and the kinase; this is a more informative binding term than generic protein binding and is consistent with the IBA node placement across Src-family kinases. |
| GO:0005102 signaling receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: Signaling receptor binding - LYN docks onto immunoreceptors and cytokine/growth-factor receptors. Reason: LYN binds and phosphorylates immunoreceptors and receptor subunits (CD79A/B, CD22, FcR subunits, KIT, EPOR, CSF2RB) via its SH2/SH3 domains and the kinase; this is a more informative binding term than generic protein binding and is consistent with the IBA node placement across Src-family kinases. |
| GO:0005161 platelet-derived growth factor receptor binding | IEA GO_REF:0000107 | UNDECIDED | Summary: The rat-derived PDGF-receptor-binding assignment needs its target complex resolved. Reason: PMID:15504915 clearly distinguishes Lyn-driven progenitor proliferation from Fyn-driven differentiation. Its accessible text does not expose the exact LynβPDGFR binding assay; a normal PMC retrieval encountered an access challenge. This is not grounds to reject the curated rat-to-human binding inference. |
| GO:0005178 integrin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Integrin binding (electronic transfer from rat ortholog). Reason: LYN functions in integrin signaling and regulates integrin activation, so an association is plausible, but direct integrin binding is not a core, human-validated molecular function; kept as non-core. |
| GO:0005515 protein binding | IPI PMID:11306681 Molecular cloning, genomic positioning, promoter identificat... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:11306681 reports association with UniProtKB:P27815. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:11517336 Interaction between growth arrest-DNA damage protein 34 and ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:11517336 reports association with UniProtKB:O75807. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:11782428 BANK regulates BCR-induced calcium mobilization by promoting... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:11782428 reports association with UniProtKB:Q8NDB2. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:14993658 The hepatitis C virus NS5A protein binds to members of the S... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:14993658 reports association with UniProtKB:O92972. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:14993658 The hepatitis C virus NS5A protein binds to members of the S... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:14993658 reports association with UniProtKB:P27958. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:14993658 The hepatitis C virus NS5A protein binds to members of the S... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:14993658 reports association with UniProtKB:Q9WMX2. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:15546919 ARAP3 is transiently tyrosine phosphorylated in cells attach... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:15546919 reports association with UniProtKB:Q8R5G7. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:15784897 Further studies on hepatitis C virus NS5A-SH3 domain interac... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:15784897 reports association with UniProtKB:O92972. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:15784897 Further studies on hepatitis C virus NS5A-SH3 domain interac... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:15784897 reports association with UniProtKB:P27958. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:15784897 Further studies on hepatitis C virus NS5A-SH3 domain interac... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:15784897 reports association with UniProtKB:Q9WMX2. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:16155203 Structural characterization of Lyn-SH3 domain in complex wit... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:16155203 reports association with UniProtKB:P22575. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:16374509 Identification of preferred protein interactions by phage-di... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:16374509 reports association with UniProtKB:Q13444. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:16799092 Dynamic profiling of the post-translational modifications an... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:16799092 reports association with UniProtKB:P00533. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:1715582 Membrane glycoprotein IV (CD36) is physically associated wit... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:1715582 reports association with UniProtKB:Q9HCN6. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:17254966 Cdk-inhibitory activity and stability of p27Kip1 are directl... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:17254966 reports association with UniProtKB:P46527. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:17640867 Leupaxin negatively regulates B cell receptor signaling. | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:17640867 reports association with UniProtKB:O60711. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:18070987 Oncogenic association of the Cbp/PAG adaptor protein with th... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:18070987 reports association with UniProtKB:P12931. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:18070987 Oncogenic association of the Cbp/PAG adaptor protein with th... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:18070987 reports association with UniProtKB:Q9NWQ8. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:19940238 Molecular priming of Lyn by GPVI enables an immune receptor ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:19940238 reports association with UniProtKB:Q9HCN6. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:19940238 Molecular priming of Lyn by GPVI enables an immune receptor ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:19940238 reports association with UniProtKB:Q9HCN6-1. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:20037584 CD36 ligands promote sterile inflammation through assembly o... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:20037584 reports association with UniProtKB:P16671. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:20037584 CD36 ligands promote sterile inflammation through assembly o... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:20037584 reports association with UniProtKB:Q08857. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:20159608 Matrix metalloproteinase-9 promotes chronic lymphocytic leuk... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:20159608 reports association with UniProtKB:P05556. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:21930792 SCIMP, a transmembrane adaptor protein involved in major his... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:21930792 reports association with UniProtKB:Q6UWF3. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:22581261 DOCK8 functions as an adaptor that links TLR-MyD88 signaling... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:22581261 reports association with UniProtKB:P12931. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:22624718 Tetraspanin CD37 directly mediates transduction of survival ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:22624718 reports association with UniProtKB:P11049. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:22731636 Lyn is involved in CD24-induced ERK1/2 activation in colorec... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:22731636 reports association with UniProtKB:P25063. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:22939624 Quantitative analysis of HSP90-client interactions reveals p... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:22939624 reports association with UniProtKB:P08238. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:23001182 Interactions among HCLS1, HAX1 and LEF-1 proteins are essent... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:23001182 reports association with UniProtKB:P14317. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:23764002 Epidermal growth factor receptor potentiates MCM7-mediated D... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:23764002 reports association with UniProtKB:P00533. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:23764002 Epidermal growth factor receptor potentiates MCM7-mediated D... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:23764002 reports association with UniProtKB:P33993. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:23866081 Lyn, a Src family kinase, regulates activation of epidermal ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:23866081 reports association with UniProtKB:P00533. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:23866081 Lyn, a Src family kinase, regulates activation of epidermal ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:23866081 reports association with UniProtKB:P63244. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:23866081 Lyn, a Src family kinase, regulates activation of epidermal ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:23866081 reports association with UniProtKB:Q9NWQ8. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:24658140 reports association with UniProtKB:P00533. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:24728074 reports association with UniProtKB:P08581. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:24728074 reports association with UniProtKB:P10275. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:24728074 reports association with UniProtKB:P10721. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:24728074 reports association with UniProtKB:Q13480. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:25825872 Preferred SH3 domain partners of ADAM metalloproteases inclu... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:25825872 reports association with UniProtKB:O43184. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:25825872 Preferred SH3 domain partners of ADAM metalloproteases inclu... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:25825872 reports association with UniProtKB:Q13444. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:31980649 reports association with UniProtKB:P00533. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:31980649 reports association with UniProtKB:P08238. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32707033 reports association with UniProtKB:P12931. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:P01023. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:P05067. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:P07602. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:P27986-2. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:P37840. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:P50570-2. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:P51608. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:Q7Z699. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:Q96GW7. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:Q96L34. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:32814053 reports association with UniProtKB:Q9BS26. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:7859737 Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains ... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:7859737 reports association with UniProtKB:P03406. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:8647200 Involvement of p72syk kinase, p53/56lyn kinase and phosphati... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:8647200 reports association with UniProtKB:P20273. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:8753773 Association of CD24 with the kinase c-fgr in a small cell lu... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:8753773 reports association with UniProtKB:P25063. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:9020138 Involvement of p130(Cas) and p105(HEF1), a novel Cas-like do... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:9020138 reports association with UniProtKB:P56945. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005515 protein binding | IPI PMID:9020138 Involvement of p130(Cas) and p105(HEF1), a novel Cas-like do... | REMOVE | Summary: The source interaction remains preserved in the annotation record. Reason: Bare protein binding is removed as uninformative under current policy, not as false. PMID:9020138 reports association with UniProtKB:Q6P5Z4. The kinase, SH2 recognition and independently supported partner-class functions are assessed separately. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: ATP binding - required for the kinase reaction. Reason: LYN binds ATP in the catalytic cleft (UniProt: BINDING 253-261, K275). Correct cofactor-binding MF for a protein kinase. |
| GO:0005634 nucleus | IDA PMID:18817770 Nuclear localization of Lyn tyrosine kinase mediated by inhi... | ACCEPT | Summary: Nucleus - a documented secondary pool of LYN, notably in the DNA-damage response. Reason: A nuclear LYN pool is directly demonstrated (PMID:18817770) and is activated in the response to genotoxic stress (PMID:10891478). Accepted, though it is secondary to the plasma-membrane pool. Supporting Evidence: PMID:18817770 Lyn was definitely detected in purified nuclei by immunofluorescence and immunoblotting analyses. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: Nucleus - a documented secondary pool of LYN, notably in the DNA-damage response. Reason: A nuclear LYN pool is directly demonstrated (PMID:18817770) and is activated in the response to genotoxic stress (PMID:10891478). Accepted, though it is secondary to the plasma-membrane pool. |
| GO:0005634 nucleus | ISS GO_REF:0000024 | ACCEPT | Summary: Nucleus - a documented secondary pool of LYN, notably in the DNA-damage response. Reason: A nuclear LYN pool is directly demonstrated (PMID:18817770) and is activated in the response to genotoxic stress (PMID:10891478). Accepted, though it is secondary to the plasma-membrane pool. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | MODIFY | Summary: Lyn has cytosolic and defined intracellular membrane-associated pools. Reason: Refine the cytoplasmic umbrella to the already supported cytosol, perinuclear cytoplasm and Golgi apparatus pools. The Golgi trafficking experiments (PMID:15173188 and PMID:20605918) and curated subcellular distribution support these locations; the nucleus and plasma-membrane claims remain separately assessed. |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | MODIFY | Summary: Lyn has cytosolic and defined intracellular membrane-associated pools. Reason: Refine the cytoplasmic umbrella to the already supported cytosol, perinuclear cytoplasm and Golgi apparatus pools. The Golgi trafficking experiments (PMID:15173188 and PMID:20605918) and curated subcellular distribution support these locations; the nucleus and plasma-membrane claims remain separately assessed. |
| GO:0005765 lysosomal membrane | TAS Reactome:R-HSA-9707977 | KEEP AS NON CORE | Summary: Lysosomal membrane (Reactome TAS; CSF3R degradation reaction compartment). Reason: Recorded as the compartment of a specific Reactome reaction (CSF3R receptor down-modulation). Accurate for that reaction context but not a core LYN location; kept as non-core. |
| GO:0005794 Golgi apparatus | IDA GO_REF:0000052 | ACCEPT | Summary: Golgi apparatus - biosynthetic trafficking compartment for LYN. Reason: Newly synthesized LYN accumulates on the Golgi and is trafficked to the plasma membrane along the secretory pathway (PMID:15173188, PMID:20605918). Well supported. |
| GO:0005794 Golgi apparatus | IDA PMID:15173188 Trafficking of Lyn through the Golgi caveolin involves the c... | ACCEPT | Summary: Golgi apparatus - biosynthetic trafficking compartment for LYN. Reason: Newly synthesized LYN accumulates on the Golgi and is trafficked to the plasma membrane along the secretory pathway (PMID:15173188, PMID:20605918). Well supported. Supporting Evidence: PMID:15173188 biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway |
| GO:0005794 Golgi apparatus | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | ACCEPT | Summary: Golgi apparatus - biosynthetic trafficking compartment for LYN. Reason: Newly synthesized LYN accumulates on the Golgi and is trafficked to the plasma membrane along the secretory pathway (PMID:15173188, PMID:20605918). Well supported. Supporting Evidence: PMID:20605918 After synthesis in the cytoplasm, Lyn accumulates on the Golgi and is subsequently transported to the plasma membrane. |
| GO:0005794 Golgi apparatus | IEA GO_REF:0000044 | ACCEPT | Summary: Golgi apparatus - biosynthetic trafficking compartment for LYN. Reason: Newly synthesized LYN accumulates on the Golgi and is trafficked to the plasma membrane along the secretory pathway (PMID:15173188, PMID:20605918). Well supported. |
| GO:0005829 cytosol | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-114577 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-114600 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1168459 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-139842 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433418 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433428 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433451 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433454 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433456 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433488 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433506 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433514 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433542 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470009 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470010 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470012 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1472121 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1562641 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2029459 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205234 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205238 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205244 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205319 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-210291 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388829 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388831 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388833 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928604 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928607 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928627 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928628 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928642 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928645 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928651 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4093327 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4093336 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-432295 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-437118 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453183 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453200 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5621355 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5624486 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9012657 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9021627 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027272 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027273 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027275 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027281 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9029150 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664261 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664275 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670412 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670413 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670414 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670416 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670417 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670418 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670426 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9709454 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Propagation Review Root cause: TERM SCOPING PROBLEM Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | IDA PMID:15173188 Trafficking of Lyn through the Golgi caveolin involves the c... | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: PMID:15173188 biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway |
| GO:0005886 plasma membrane | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | IDA PMID:32958780 CD36 facilitates fatty acid uptake by dynamic palmitoylation... | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: The curated human record places lipid-anchored LYN at the cytoplasmic face of the cell membrane. PMID:32958780 uses mouse Lyn cDNA with human CD36/DHHC5 in heterologous experiments and mouse adipocyte models; it supports the conserved membrane-associated signaling context without becoming a direct human LYN localization assay. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/LYN/LYN-uniprot.txt The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2454208 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2454240 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730833 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730843 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730851 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730862 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730882 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730884 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730886 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5690702 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9674816 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9677579 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9677585 | MODIFY | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the inherited localization is compatible with direct LYN membrane-recruitment evidence. The more specific supported term the gene already carries is cytoplasmic side of plasma membrane (GO:0009898) -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane |
| GO:0005912 adherens junction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: LYN has comparative biochemical support for an adherens-junction pool. Reason: The rat donor source PMID:1709169 identifies Lyn in isolated hepatocyte adherens junctions by immunoblot/biochemistry. Its microscopy emphasized Src/Yes, so do not claim direct human LYN imaging. The conserved location is retained rather than rejected for being outside the dominant immune-cell literature. Supporting Evidence: PMID:1709169 As a result, three proto-oncogenic tyrosine kinases of src family, c-yes, c-src, and lyn kinases, were identified as major tyrosine kinases in the cell-to-cell AJ of hepatocytes. |
| GO:0006468 protein phosphorylation | IDA PMID:11517336 Interaction between growth arrest-DNA damage protein 34 and ... | MODIFY | Summary: LYN phosphorylates tyrosine residues in proteins, including regulatory autophosphorylation. Reason: Refine the general protein-phosphorylation process to tyrosine phosphorylation and self-phosphorylation, both already represented. LYN phosphorylates the GADD34/MyD116-associated stress-response system in the tested cell context. Proposed replacements: peptidyl-tyrosine phosphorylation protein autophosphorylation Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0006468 protein phosphorylation | TAS PMID:3561390 The yes-related cellular gene lyn encodes a possible tyrosin... | MODIFY | Summary: LYN phosphorylates tyrosine residues in proteins, including regulatory autophosphorylation. Reason: Refine the general protein-phosphorylation process to tyrosine phosphorylation and self-phosphorylation, both already represented. The original sequence characterization is complemented by direct LYN kinase/substrate experiments. Proposed replacements: peptidyl-tyrosine phosphorylation protein autophosphorylation Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0006952 defense response | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Defense response. Reason: Broad immune/defense process consistent with LYN's role in innate and adaptive immunity; retained as non-core. |
| GO:0006954 inflammatory response | IDA PMID:20037584 CD36 ligands promote sterile inflammation through assembly o... | KEEP AS NON CORE | Summary: Inflammatory response. Reason: LYN participates in inflammatory signaling (e.g. CD36-TLR4/6 assembly, PMID:20037584); a genuine but downstream, non-core process. Supporting Evidence: PMID:20037584 these data support a role for CD36-Lyn kinase interactions initiated at Tyr463 in facilitating TLR4-TLR6 heterodimerization and signal initiation |
| GO:0006974 DNA damage response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: DNA damage response. Reason: LYN participates in the response to genotoxic agents (e.g. phosphorylating GADD34/PPP1R15A) (PMID:11517336). Non-core role. The IBA node placement reflects a conserved Src-family involvement. |
| GO:0006974 DNA damage response | IDA PMID:11517336 Interaction between growth arrest-DNA damage protein 34 and ... | KEEP AS NON CORE | Summary: DNA damage response. Reason: LYN participates in the response to genotoxic agents (e.g. phosphorylating GADD34/PPP1R15A) (PMID:11517336). Non-core role. The IBA node placement reflects a conserved Src-family involvement. Supporting Evidence: PMID:11517336 these two proteins physically and functionally interact to regulate DNA damage-induced apoptosis |
| GO:0006991 response to sterol depletion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cholesterol depletion disrupts LynβFcΞ΅RI signaling associations. Reason: The native rat RBL study uses methyl-beta-cyclodextrin to deplete cholesterol and then restores cholesterol. LynβFcΞ΅RI association and receptor phosphorylation decrease and recover together. Retain the sterol-dependent signaling response as a conserved biochemical inference, without converting membrane sensitivity into a dedicated sterol sensor. Supporting Evidence: PMID:10330413 Importantly, cholesterol repletion restores receptor phosphorylation together with the structural interactions. |
| GO:0007165 signal transduction | TAS PMID:7650013 G protein-coupled chemoattractant receptors regulate Lyn tyr... | MODIFY | Summary: LYN transduces immunoreceptor and other receptor signals through tyrosine phosphorylation. Reason: The original PMID:7650013 pathway context is retained. Refine broad signaling to the immune cell-surface receptor route and the independently supported receptor tyrosine kinase route; the formyl-peptide neutrophil experiment also supports a GPCR context and is not mislabeled as a BCR assay. Proposed replacements: immune response-regulating cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway G protein-coupled receptor signaling pathway Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Cell surface receptor protein tyrosine kinase signaling pathway. Reason: LYN participates downstream of the receptor tyrosine kinase KIT, independently of the thrombopoietin-receptor context emphasized in PMID:14726379. KIT-associated signaling is supported by PMID:11435302 and curated LYN function. EPOR and the thrombopoietin receptor are cytokine receptors with associated kinases, not receptor tyrosine kinases; they are not used as the defining examples for this term. |
| GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway | IMP PMID:14726379 Lyn tyrosine kinase regulates thrombopoietin-induced prolife... | KEEP AS NON CORE | Summary: Cell surface receptor protein tyrosine kinase signaling pathway. Reason: LYN participates downstream of the receptor tyrosine kinase KIT, independently of the thrombopoietin-receptor context emphasized in PMID:14726379. KIT-associated signaling is supported by PMID:11435302 and curated LYN function. EPOR and the thrombopoietin receptor are cytokine receptors with associated kinases, not receptor tyrosine kinases; they are not used as the defining examples for this term. |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Positive regulation of cell population proliferation. Reason: Downstream proliferative outcome in several hematopoietic contexts; non-core. |
| GO:0008284 positive regulation of cell population proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of cell population proliferation. Reason: Downstream proliferative outcome in several hematopoietic contexts; non-core. |
| GO:0008285 negative regulation of cell population proliferation | IMP PMID:14726379 Lyn tyrosine kinase regulates thrombopoietin-induced prolife... | KEEP AS NON CORE | Summary: Negative regulation of cell population proliferation. Reason: LYN can restrain proliferation (e.g. thrombopoietin context, PMID:14726379); a context-dependent, non-core outcome reflecting its dualistic role. |
| GO:0009410 response to xenobiotic stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: LynA joins a cardiac signaling complex during drug-mediated reversal of hypertrophy. Reason: The rat pressure-overload study detects LynA in PKCΞ΅ complexes during fosinopril/carvedilol treatment. This is a contextual protein-complex response, not proof that LYN directly binds these drugs or independently causes their clinical benefit. Supporting Evidence: PMID:17039281 The two significant PKC epsilon-binding proteins, MAD1 and Lyn A, were only present in PKC epsilon complex during reversing POH with drugs. |
| GO:0009636 response to toxic substance | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Lyn expression changes after a neurotoxic dopamine-denervation lesion. Reason: The rat 6-OHDA experiment measures Lyn expression after dopaminergic injury and L-DOPA treatment. Retain the existing response as a qualified comparative expression-response annotation; it does not establish direct toxin recognition, detoxification or a requirement for LYN in neuronal killing. Supporting Evidence: PMID:16529858 only the acute treatment with L-DOPA corrected the decrease in Src, Lyn and PKC kinase expression induced by 6-OHDA lesion. |
| GO:0009725 response to hormone | ISS GO_REF:0000024 | MODIFY | Summary: Lyn responds to peptide-hormone stimulation in defined peripheral tissues. Reason: Refine the general hormone response to peptide-hormone response, supported by rat CCK-induced acinar Lyn activation (PMID:16713446) and insulin-induced hepatic Lyn autophosphorylation (PMID:12089355). The specific insulin response remains separately retained; these are comparative biochemical contexts, not universal hormonal control. Proposed replacements: response to peptide hormone Supporting Evidence: PMID:16713446 CCK, a physiological regulator of pancreatic function, rapidly activated Lyn. |
| GO:0009743 response to carbohydrate | IEA GO_REF:0000107 | MODIFY | Summary: Cyclodextrin exposure alters Lyn-dependent signaling by extracting cholesterol. Reason: The donor experiment uses the carbohydrate derivative methyl-beta-cyclodextrin, but the mechanistically resolved perturbation is sterol depletion. Refine to the separately supported sterol-depletion response as a lateral stimulus clarification, not a claim that this is an is_a descendant of carbohydrate response. Proposed replacements: response to sterol depletion Supporting Evidence: PMID:10330413 cholesterol depletion with methyl-beta-cyclodextrin substantially reduces stimulated tyrosine phosphorylation of FcepsilonRI and other proteins |
| GO:0009898 cytoplasmic side of plasma membrane | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | ACCEPT | Summary: Cytoplasmic side of plasma membrane - precise functional location. Reason: LYN is anchored to and active at the inner leaflet of the plasma membrane; this is a precise, correct location for its receptor-proximal signaling function. |
| GO:0010976 positive regulation of neuron projection development | IMP PMID:17910947 Identification of twinfilin-2 as a factor involved in neurit... | KEEP AS NON CORE | Summary: Positive regulation of neuron projection development. Reason: Neurite-outgrowth role reported in an RNAi screen context (PMID:17910947); a minor, non-core role for human LYN. |
| GO:0014003 oligodendrocyte development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Lyn supports the proliferative stage of oligodendrocyte development. Reason: The rat donor study PMID:15504915 distinguishes Lyn-dependent alphaVbeta3 progenitor proliferation from Fyn-dependent differentiation/myelin formation. Retain the comparative developmental role without assigning the Fyn-specific differentiation mechanism to human LYN. Supporting Evidence: PMID:15504915 earlier in the lineage Lyn, not Fyn, is required to drive alphaVbeta3-dependent progenitor proliferation. |
| GO:0015908 fatty acid transport | IDA PMID:32958780 CD36 facilitates fatty acid uptake by dynamic palmitoylation... | KEEP AS NON CORE | Summary: Fatty acid transport. Reason: LYN acts in CD36 palmitoylation/endocytosis affecting fatty-acid uptake (PMID:32958780), but it regulates rather than performs transport; kept as non-core rather than asserting participation in the transport step itself. |
| GO:0016020 membrane | IEA GO_REF:0000044 | MODIFY | Summary: LYN associates with the cytoplasmic face of the plasma membrane and traffics through the Golgi. Reason: Refine generic membrane to the supported plasma-membrane pool. Separate Golgi apparatus and endocytic-vesicle annotations remain; no root organelle annotation is discarded merely because a subcompartment is known. Proposed replacements: plasma membrane Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0016301 kinase activity | NAS PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | MODIFY | Summary: LYN is a non-membrane-spanning protein tyrosine kinase. Reason: Refine kinase activity to the supported Src-family catalytic activity. LYN is lipid anchored, not a transmembrane receptor kinase. The EphA4/APP context involves LYN-dependent receptor phosphorylation and feedback, not a new kinase class. The refinement judges the enzyme function rather than discarding a true broad annotation. Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0018108 peptidyl-tyrosine phosphorylation | IDA PMID:11782428 BANK regulates BCR-induced calcium mobilization by promoting... | ACCEPT | Summary: Peptidyl-tyrosine phosphorylation - direct expression of LYN kinase activity. Reason: LYN phosphorylates tyrosine residues of substrate proteins (HS1/HCLS1, PMID:7682714; IP3R via BANK, PMID:11782428). Direct catalytic process. Supporting Evidence: PMID:11782428 BANK promotes Lyn-mediated tyrosine phosphorylation of IP(3)R. |
| GO:0018108 peptidyl-tyrosine phosphorylation | IDA PMID:7682714 Identification of HS1 protein as a major substrate of protei... | ACCEPT | Summary: Peptidyl-tyrosine phosphorylation - direct expression of LYN kinase activity. Reason: LYN phosphorylates tyrosine residues of substrate proteins (HS1/HCLS1, PMID:7682714; IP3R via BANK, PMID:11782428). Direct catalytic process. Supporting Evidence: PMID:7682714 p75HS1 showed rapid tyrosine phosphorylation and association with a Src-like kinase, Lyn, after crosslinking of membrane-bound IgM. |
| GO:0019899 enzyme binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: LYN binds several enzyme partners in signaling complexes. Reason: The rat donor chain includes dynamin binding to Lyn SH3 (PMID:8757630) and PKCΞ΄ association with Lyn SH2 (PMID:9692543). Enzyme binding is a functional partner class and is not covered by the bare GO:0005515 removal rule. Multiple enzyme classes preclude replacing all evidence with a single narrower partner type. Supporting Evidence: PMID:8757630 Dynamin was shown to associate with the SH3 domain of the src-related tyrosine kinase p56lyn in RBL 2H3 cells both in vitro and in vivo. |
| GO:0030061 mitochondrial crista | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Rat mitochondrial immunogold evidence places Lyn in the cristal lumen. Reason: PMID:12007793 supports the inherited crista-associated compartment, with the important topological qualification that Lyn signal is in the lumen/intermembrane space. This is a comparative location, not evidence that human LYN is an integral inner-membrane protein. Supporting Evidence: PMID:12007793 Instead, Src tyrosine kinases are mainly located in the intermembrane space - in particular, as revealed by immunogold experiments for Lyn kinase, in the cristal lumen. |
| GO:0030218 erythrocyte differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Erythrocyte differentiation. Reason: LYN acts downstream of EPOR in erythroid contexts; a downstream, non-core differentiation outcome (ISS). |
| GO:0030222 eosinophil differentiation | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | KEEP AS NON CORE | Summary: Eosinophil differentiation. Reason: LYN associates with IL-5Ralpha and is required for eosinophil differentiation (PMID:11823534); a lineage-specific, non-core outcome. Supporting Evidence: PMID:11823534 Lyn antisense oligodeoxynucleotide blocks eosinophil differentiation from stem cells in a dose-dependent manner. |
| GO:0030546 signaling receptor activator activity | IDA PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | KEEP AS NON CORE | Summary: LYN-dependent phosphorylation can promote EphA4 receptor activation/feedback. Reason: The live GO definition permits receptor activation through direct or indirect interaction; a kinase is not categorically excluded. PMID:24217950 describes Lyn-dependent EphA4 phosphorylation and feedback, and publisher supplementary co-IP demonstrates EphA4βLyn association in engineered T20 cells. Retain the bounded receptor-activator context, not a universal ligand-like activity. Supporting Evidence: PMID:24217950 EphA4 induced accumulation of C99 and AICD through a Lyn-dependent pathway; activation of this pathway triggered phosphorylation of EphA4, resulting in positive feedback of C99 and AICD proteostasis. |
| GO:0030666 endocytic vesicle membrane | TAS Reactome:R-HSA-9705738 | KEEP AS NON CORE | Summary: Endocytic vesicle membrane (Reactome TAS; receptor internalization reactions). Reason: Reaction-compartment annotation from Reactome receptor-endocytosis models; accurate for those reactions but not a core location; kept as non-core. |
| GO:0030666 endocytic vesicle membrane | TAS Reactome:R-HSA-9707977 | KEEP AS NON CORE | Summary: Endocytic vesicle membrane (Reactome TAS; receptor internalization reactions). Reason: Reaction-compartment annotation from Reactome receptor-endocytosis models; accurate for those reactions but not a core location; kept as non-core. |
| GO:0031175 neuron projection development | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Neuron projection development. Reason: IBA node includes a neural-development role across the family; minor and non-core for LYN specifically. |
| GO:0031295 T cell costimulation | TAS Reactome:R-HSA-388841 | KEEP AS NON CORE | Summary: T cell costimulation. Reason: Reactome CD28-family costimulation context; LYN's role in T cells is minor relative to LCK/FYN. Non-core. |
| GO:0031295 T cell costimulation | TAS Reactome:R-HSA-389356 | KEEP AS NON CORE | Summary: T cell costimulation. Reason: Reactome CD28-family costimulation context; LYN's role in T cells is minor relative to LCK/FYN. Non-core. |
| GO:0031625 ubiquitin protein ligase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: LYN associates with Cbl-family ubiquitin ligases. Reason: The rat source PMID:14531861 measures FcΞ΅RI-induced Lyn association with c-Cbl/Cbl-b and consequent ubiquitination. Retain the conserved binding claim; being the ubiquitinated substrate would not itself justify a new ubiquitination-process annotation. Supporting Evidence: PMID:14531861 Stimulation of Fc epsilon RI results in the association of Lyn with c-Cbl and Cbl-b, both of which then become tyrosine phosphorylated. |
| GO:0031663 lipopolysaccharide-mediated signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Lipopolysaccharide-mediated signaling pathway. Reason: LYN modulates LPS/TLR4 signaling in myeloid cells (dual positive/negative); a genuine but non-core process. |
| GO:0031966 mitochondrial membrane | IEA GO_REF:0000107 | UNDECIDED | Summary: Mitochondrial association is supported, but the membrane-specific topology remains unresolved. Reason: The rat source PMID:12007793 distinguishes membrane-associated phosphoprotein substrates from Src-family kinases mainly in the intermembrane space/cristal lumen. It does not, in the accessible text, establish the precise membrane association of Lyn itself. Retain uncertainty without rejecting the broader mitochondrial/crista evidence. Supporting Evidence: PMID:12007793 Instead, Src tyrosine kinases are mainly located in the intermembrane space - in particular, as revealed by immunogold experiments for Lyn kinase, in the cristal lumen. |
| GO:0032868 response to insulin | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Insulin activates Lyn in perfused rat liver. Reason: The full abstract separates insulin from leptin: insulin increases Lyn/Fak autophosphorylation whereas leptin does not. Retain the insulin response as comparative biochemical evidence; the paper title emphasizing leptin does not make the Lyn assay a miscitation. Supporting Evidence: PMID:12089355 Insulin alone (P < 0.01), but not leptin, increased autophosphorylation of nonreceptor tyrosine kinases (pp59(Lyn) + pp125(Fak)). |
| GO:0033003 regulation of mast cell activation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of mast cell activation. Reason: LYN is a proximal kinase in FcepsilonRI signaling that regulates mast-cell activation (dual role); downstream, non-core process. |
| GO:0033628 regulation of cell adhesion mediated by integrin | IMP PMID:18802065 Monocyte migration and LFA-1-mediated attachment to brain mi... | KEEP AS NON CORE | Summary: Regulation of cell adhesion mediated by integrin. Reason: LYN regulates beta2-integrin (LFA-1) adhesion downstream of chemokine receptors (PMID:18802065, PMID:16467205); a real but non-core process. Supporting Evidence: PMID:18802065 in SDF-1alpha-stimulated monocytes, Lyn acts as a positive regulator of migration and a negative regulator of adhesion to BMVEC through the LFA-1 integrin |
| GO:0034136 negative regulation of toll-like receptor 2 signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of toll-like receptor 2 signaling pathway. Reason: LYN restrains TLR2 signaling in myeloid cells (ISS); non-core. |
| GO:0034144 negative regulation of toll-like receptor 4 signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of toll-like receptor 4 signaling pathway. Reason: Raft-associated LYN negatively regulates LPS/TLR4 signaling; a genuine but non-core (and context-dependent) process. |
| GO:0034145 positive regulation of toll-like receptor 4 signaling pathway | IDA PMID:17392283 Role of TLR4 tyrosine phosphorylation in signal transduction... | KEEP AS NON CORE | Summary: Positive regulation of toll-like receptor 4 signaling pathway. Reason: LYN can also positively regulate TLR4 signaling (TLR4 tyrosine phosphorylation; CD36-TLR4/6 assembly); reflects its dualistic role. Non-core process. |
| GO:0034165 positive regulation of toll-like receptor 9 signaling pathway | IDA PMID:40980882 TLR9 signaling requires ligand-induced phosphorylation of tw... | KEEP AS NON CORE | Summary: Positive regulation of toll-like receptor 9 signaling pathway. Reason: LYN, with Syk and EGFR, phosphorylates and activates TLR9 (PMID:40980882); a genuine but non-core process. Supporting Evidence: PMID:40980882 TLR9 required two Src family of kinases, Syk and Lyn, which, together with EGFR, led to phosphorylation and activation of TLR9 |
| GO:0034605 cellular response to heat | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Lyn participates in neutrophil activation after thermal injury. Reason: The rat study measures Lyn activation and neutrophil oxidant production after a burn, with kinase inhibitors and a platelet-activating-factor antagonist. Retain this systemic thermal-injury response; it does not demonstrate direct thermosensing by LYN or heating of isolated neutrophils, and the inhibitors are not LYN-selective. Supporting Evidence: PMID:12372808 Thermal injury caused marked upregulation of Lyn and ERK1/2 accompanying enhanced neutrophil O production. |
| GO:0034666 integrin alpha2-beta1 complex | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: LYN associates with an integrin-containing sensory signaling assembly rather than being an alpha2-beta1 integrin subunit. Reason: The live GO definition describes the alpha2/beta1 heterodimer. Full PMID:18234883 co-immunoprecipitates TRPV4 with alpha2 integrin and Lyn from rat dorsal-root-ganglion neurons, supporting a larger associated complex, not membership as one of the two integrin chains. Preserve the interaction through the separate complex-binding annotation. Supporting Evidence: PMID:18234883 Furthermore, we establish a direct interaction between TRPV4, alpha2 integrin, and the Src tyrosine kinase Lyn in sensory neurons. |
| GO:0034987 immunoglobulin receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Immunoglobulin receptor binding (electronic transfer from rat ortholog). Reason: Consistent with LYN association with Fc receptors and the BCR complex, but a peripheral binding descriptor rather than a core function; kept as non-core. |
| GO:0035556 intracellular signal transduction | IEA GO_REF:0000117 | MODIFY | Summary: LYN transduces immunoreceptor and other receptor signals through tyrosine phosphorylation. Reason: The original GO_REF:0000117 pathway context is retained. Refine broad signaling to the immune cell-surface receptor route and the independently supported receptor tyrosine kinase route; the formyl-peptide neutrophil experiment also supports a GPCR context and is not mislabeled as a BCR assay. Proposed replacements: immune response-regulating cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway G protein-coupled receptor signaling pathway Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0038043 interleukin-5-mediated signaling pathway | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | KEEP AS NON CORE | Summary: Interleukin-5-mediated signaling pathway. Reason: LYN associates with IL-5Ralpha and phosphorylates it (PMID:11823534); a lineage-specific, non-core signaling branch. Supporting Evidence: PMID:11823534 only Lyn is associated with the IL-5Ralpha under basal conditions |
| GO:0038095 Fc-epsilon receptor signaling pathway | TAS Reactome:R-HSA-2454202 | ACCEPT | Summary: Fc-epsilon receptor signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN phosphorylates the FcepsilonRI beta and gamma ITAMs to initiate mast-cell/basophil signaling; a defining direct role (Reactome; UniProt FUNCTION). |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Fc-gamma receptor signaling pathway involved in phagocytosis. Reason: LYN contributes to FcgammaR-mediated phagocytic signaling in myeloid cells; a genuine but non-core process (partly redundant with other SFKs). |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | TAS Reactome:R-HSA-2029480 | KEEP AS NON CORE | Summary: Fc-gamma receptor signaling pathway involved in phagocytosis. Reason: LYN contributes to FcgammaR-mediated phagocytic signaling in myeloid cells; a genuine but non-core process (partly redundant with other SFKs). |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | TAS Reactome:R-HSA-9664422 | KEEP AS NON CORE | Summary: Fc-gamma receptor signaling pathway involved in phagocytosis. Reason: LYN contributes to FcgammaR-mediated phagocytic signaling in myeloid cells; a genuine but non-core process (partly redundant with other SFKs). |
| GO:0038159 C-X-C chemokine receptor CXCR4 signaling pathway | IMP PMID:16467205 Integrin inhibition through Lyn-dependent cross talk from CX... | KEEP AS NON CORE | Summary: C-X-C chemokine receptor CXCR4 signaling pathway. Reason: LYN mediates CXCR4-driven migration/adhesion crosstalk in hematopoietic cells (PMID:16467205); a real but non-core process. Supporting Evidence: PMID:16467205 in chemokine-stimulated hematopoietic cells Lyn kinase is a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta(2) integrins |
| GO:0042100 B cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: B cell proliferation. Reason: Downstream B-cell outcome of LYN signaling; non-core. |
| GO:0042327 positive regulation of phosphorylation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of phosphorylation. Reason: Process-level restatement of kinase activity (electronic ortholog transfer); non-core. |
| GO:0043015 gamma-tubulin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: LYN binds gamma-tubulin in a mast-cell signaling context. Reason: The rat source PMID:10545487 includes binding to a recombinant Lyn N-terminal fragment and activation-dependent complexes. This is concrete ortholog evidence for the human transfer, not an unsupported inference from generic cytoskeletal involvement. Supporting Evidence: PMID:10545487 Furthermore, gamma-tubulin bound to the N-terminal fragment of recombinant Lyn kinase and its binding was slightly enhanced in activated cells. |
| GO:0043200 response to amino acid | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: L-DOPA treatment modifies Lyn expression after dopaminergic injury. Reason: The rat donor study tests the amino-acid derivative L-DOPA in a 6-OHDA lesion model. Acute and chronic treatment have different effects on kinase expression. Retain this bounded comparative response without asserting direct amino-acid binding or metabolism by LYN. Supporting Evidence: PMID:16529858 only the acute treatment with L-DOPA corrected the decrease in Src, Lyn and PKC kinase expression induced by 6-OHDA lesion. |
| GO:0043208 glycosphingolipid binding | IEA GO_REF:0000107 | UNDECIDED | Summary: LYN associates with ganglioside-containing complexes, but direct glycosphingolipid binding is unresolved. Reason: PMID:8106508 reports specific AA4/GD1b-associated Lyn complexes in rat RBL cells and explicitly discusses a possible protein bridge. This supports association, while leaving direct lipid recognition uncertain. Raft localization is not used as proof either for or against lipid binding. Supporting Evidence: PMID:8106508 The same 71-80-kDa tyrosine-phosphorylated proteins were immunoprecipitated by mAb AA4 and anti-Lyn antibodies and may play a role in the interaction of p53/56lyn with the gangliosides. |
| GO:0043304 regulation of mast cell degranulation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of mast cell degranulation. Reason: LYN regulates FcepsilonRI-driven mast-cell degranulation (dual role); downstream, non-core process. |
| GO:0043407 negative regulation of MAP kinase activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of MAP kinase activity. Reason: Reflects LYN's inhibitory arm dampening MAPK signaling in some contexts; non-core. |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:10891478 Role for Lyn tyrosine kinase as a regulator of stress-activa... | KEEP AS NON CORE | Summary: Positive regulation of MAPK cascade (SAPK/JNK in DNA-damage context). Reason: LYN can activate the SAPK/JNK cascade after DNA damage (PMID:10891478); a context-specific, non-core signaling output. Supporting Evidence: PMID:10891478 activation of SAPK by DNA damage is mediated in part by Lyn |
| GO:0043434 response to peptide hormone | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cholecystokinin rapidly activates Lyn in pancreatic acini. Reason: Native rat pancreatic acini show CCK-dependent Lyn activation involving Ca2+ and PKC, with recruitment of specific signaling partners. This provides a defined peptide-hormone context for the human ortholog inference; it is not a claim that every hormone activates LYN. Supporting Evidence: PMID:16713446 CCK, a physiological regulator of pancreatic function, rapidly activated Lyn. |
| GO:0044325 transmembrane transporter binding | IPI PMID:12538589 Regulation of a transient receptor potential (TRP) channel b... | KEEP AS NON CORE | Summary: Transmembrane transporter binding (IPI; TRPV4 channel). Reason: LYN interacts with and phosphorylates the TRPV4 channel (PMID:12538589); a real but peripheral interaction, kept as non-core. |
| GO:0044325 transmembrane transporter binding | IPI PMID:12538589 Regulation of a transient receptor potential (TRP) channel b... | KEEP AS NON CORE | Summary: Transmembrane transporter binding (IPI; TRPV4 channel). Reason: LYN interacts with and phosphorylates the TRPV4 channel (PMID:12538589); a real but peripheral interaction, kept as non-core. |
| GO:0044877 protein-containing complex binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: LYN interacts with multicomponent signaling complexes. Reason: The rat donor chain includes MISTβSLAP130βSKAP55 (PMID:12681493), SHIP2/FcΞ΅RI (PMID:17579026), and sensory TRPV4/integrin assemblies (PMID:18234883). Complex binding is retained at the shared warranted level and is not treated as the bare-protein-binding policy exception. Supporting Evidence: PMID:18234883 Furthermore, we establish a direct interaction between TRPV4, alpha2 integrin, and the Src tyrosine kinase Lyn in sensory neurons. |
| GO:0045121 membrane raft | IDA PMID:11313396 CD24 induces apoptosis in human B cells via the glycolipid-e... | ACCEPT | Summary: Membrane raft - functionally important microdomain localization. Reason: Palmitoylation drives LYN partitioning into cholesterol/sphingolipid-rich rafts, which enhances its activity and its coupling to immunoreceptors. Well supported and functionally significant. Supporting Evidence: PMID:12670955 Cross-linking of IgE-receptor complexes by antigen causes their coalescence with lipid rafts, where they are phosphorylated by the Src family tyrosine kinase, Lyn. |
| GO:0045121 membrane raft | IEA GO_REF:0000117 | ACCEPT | Summary: Membrane raft - functionally important microdomain localization. Reason: Palmitoylation drives LYN partitioning into cholesterol/sphingolipid-rich rafts, which enhances its activity and its coupling to immunoreceptors. Well supported and functionally significant. |
| GO:0045121 membrane raft | ISS GO_REF:0000024 | ACCEPT | Summary: Membrane raft - functionally important microdomain localization. Reason: Palmitoylation drives LYN partitioning into cholesterol/sphingolipid-rich rafts, which enhances its activity and its coupling to immunoreceptors. Well supported and functionally significant. |
| GO:0045646 regulation of erythrocyte differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of erythrocyte differentiation. Reason: LYN acts downstream of EPOR in erythroid maturation; a downstream, non-core regulatory role. |
| GO:0046777 protein autophosphorylation | IDA PMID:7682714 Identification of HS1 protein as a major substrate of protei... | ACCEPT | Summary: Protein autophosphorylation - LYN autophosphorylates its activation loop. Reason: LYN trans-autophosphorylates activation-loop Tyr397, required for optimal catalytic activity (UniProt ACTIVITY REGULATION). Direct expression of its kinase function. |
| GO:0046875 ephrin receptor binding | IPI PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | KEEP AS NON CORE | Summary: Ephrin receptor binding (IPI; EphA4). Reason: LYN interacts with EphA4 in a pathway regulating APP proteolysis (PMID:24217950); a real but context-specific, non-core interaction. |
| GO:0048013 ephrin receptor signaling pathway | IGI PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | KEEP AS NON CORE | Summary: Ephrin receptor signaling pathway. Reason: LYN acts in an EphA4-initiated pathway regulating APP proteolysis (PMID:24217950); a context-specific, non-core process. |
| GO:0048013 ephrin receptor signaling pathway | TAS Reactome:R-HSA-2682334 | KEEP AS NON CORE | Summary: Ephrin receptor signaling pathway. Reason: LYN acts in an EphA4-initiated pathway regulating APP proteolysis (PMID:24217950); a context-specific, non-core process. |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | KEEP AS NON CORE | Summary: Perinuclear region of cytoplasm (IDA/IEA; Golgi-associated pool). Reason: Consistent with the Golgi/perinuclear biosynthetic pool of LYN (PMID:20605918); a real but non-core localization. Supporting Evidence: PMID:20605918 After synthesis in the cytoplasm, Lyn accumulates on the Golgi and is subsequently transported to the plasma membrane. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Perinuclear region of cytoplasm (IDA/IEA; Golgi-associated pool). Reason: Consistent with the Golgi/perinuclear biosynthetic pool of LYN (PMID:20605918); a real but non-core localization. |
| GO:0048678 response to axon injury | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Lyn supports the microglial response to peripheral nerve injury. Reason: Native mouse Lyn knockout reduces injury-induced microglial activation, P2X4 upregulation and tactile allodynia. This provides comparative causal support for the human axon-injury response annotation, with no assertion that the mouse experiment directly measured human pain physiology. Supporting Evidence: PMID:17918263 We found that mice lacking lyn (lyn(-/-)) exhibit a striking reduction in the levels of phospho-SFK-IR and tactile allodynia after nerve injury, without any change in basal mechanical sensitivity or inflammatory pain. |
| GO:0050777 negative regulation of immune response | TAS PMID:15489917 Src-family kinases in B-cell development and signaling. | KEEP AS NON CORE | Summary: Negative regulation of immune response. Reason: Captures LYN's net inhibitory/regulatory role in immunity; a downstream, non-core process. |
| GO:0050855 regulation of B cell receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Regulation of B cell receptor signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN is the principal Src-family kinase initiating and modulating BCR signaling (phosphorylating CD79A/B ITAMs and inhibitory co-receptor ITIMs). Defining, direct role; IBA node includes P07948. |
| GO:0050855 regulation of B cell receptor signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Regulation of B cell receptor signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN is the principal Src-family kinase initiating and modulating BCR signaling (phosphorylating CD79A/B ITAMs and inhibitory co-receptor ITIMs). Defining, direct role; IBA node includes P07948. |
| GO:0050859 negative regulation of B cell receptor signaling pathway | IDA PMID:35941532 Interfering B cell receptor signaling via SHP-1/p-Lyn axis s... | ACCEPT | Summary: LYN enables inhibitory co-receptor signaling that restrains BCR responses. Reason: The biological claim is independently supported by native Lyn-null mouse CD22/SHP1 experiments (PMID:9480991; PMID:9586639), interpreted as a conserved mammalian mechanism. PMID:35941532 primarily tests SHP1 activation suppressing LYN/BCR signaling in lymphoma; that intervention is not itself proof that LYN inhibits the BCR. The core claim is retained with the appropriate causal source. Supporting Evidence: PMID:9480991 We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. file:human/LYN/LYN-deep-research-falcon.md LYN initiates ITAM-dependent signaling but also phosphorylates ITIMs that recruit SHP and SHIP phosphatases. |
| GO:0050900 leukocyte migration | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Leukocyte migration. Reason: LYN regulates leukocyte/monocyte migration and adhesion (PMID:18802065); a downstream, non-core process. |
| GO:0050900 leukocyte migration | TAS Reactome:R-HSA-202733 | KEEP AS NON CORE | Summary: Leukocyte migration. Reason: LYN regulates leukocyte/monocyte migration and adhesion (PMID:18802065); a downstream, non-core process. |
| GO:0051219 phosphoprotein binding | IEA GO_REF:0000107 | MODIFY | Summary: LYN SH2 recognizes phosphotyrosine-containing proteins. Reason: Refine phosphoprotein binding to the phosphotyrosine residue recognized by the Src-family SH2 domain. The rat binding experiment in PMID:9692543 specifically recruits tyrosine-52-phosphorylated PKCΞ΄ to Lyn SH2, supporting conserved recognition independently of a domain name. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:9692543 the tyrosine 52 phosphorylated PKC-delta was recruited to associate with the Lyn SH2 domain. |
| GO:0051279 regulation of release of sequestered calcium ion into cytosol | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Regulation of release of sequestered calcium ion into cytosol. Reason: LYN-initiated immunoreceptor signaling feeds calcium mobilization (e.g. via IP3R); electronic ortholog transfer, non-core. |
| GO:0060252 positive regulation of glial cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Lyn supports the proliferative stage of oligodendrocyte development. Reason: The rat donor study PMID:15504915 distinguishes Lyn-dependent alphaVbeta3 progenitor proliferation from Fyn-dependent differentiation/myelin formation. Retain the comparative developmental role without assigning the Fyn-specific differentiation mechanism to human LYN. Supporting Evidence: PMID:15504915 earlier in the lineage Lyn, not Fyn, is required to drive alphaVbeta3-dependent progenitor proliferation. |
| GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of Fc receptor mediated stimulatory signaling pathway. Reason: Reflects LYN's activating ITAM-phosphorylation role at the regulatory level (electronic ortholog transfer); non-core. |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | TAS Reactome:R-HSA-982772 | KEEP AS NON CORE | Summary: Growth hormone receptor signaling pathway via JAK-STAT. Reason: Reactome cytokine-receptor context (JAK-STAT); LYN participation is peripheral, non-core. |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | KEEP AS NON CORE | Summary: Extracellular exosome (HDA; proteomic detection). Reason: High-throughput proteomic detection in exosome/secretion preparations; not evidence of a functional exosomal role. Kept as non-core. |
| GO:0070372 regulation of ERK1 and ERK2 cascade | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of ERK1 and ERK2 cascade. Reason: LYN modulates ERK signaling downstream of several receptors; a downstream, non-core process. |
| GO:0070373 negative regulation of ERK1 and ERK2 cascade | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of ERK1 and ERK2 cascade. Reason: Reflects LYN's inhibitory arm dampening ERK signaling in some contexts; non-core. |
| GO:0070447 positive regulation of oligodendrocyte progenitor proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Lyn supports the proliferative stage of oligodendrocyte development. Reason: The rat donor study PMID:15504915 distinguishes Lyn-dependent alphaVbeta3 progenitor proliferation from Fyn-dependent differentiation/myelin formation. Retain the comparative developmental role without assigning the Fyn-specific differentiation mechanism to human LYN. Supporting Evidence: PMID:15504915 earlier in the lineage Lyn, not Fyn, is required to drive alphaVbeta3-dependent progenitor proliferation. |
| GO:0070667 negative regulation of mast cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of mast cell proliferation. Reason: Context-dependent negative regulation of mast-cell proliferation (ISS); non-core, reflecting dualistic role. |
| GO:0070668 positive regulation of mast cell proliferation | IMP PMID:11435302 Lyn is required for normal stem cell factor-induced prolifer... | KEEP AS NON CORE | Summary: Positive regulation of mast cell proliferation. Reason: LYN is required for SCF/KIT-induced mast-cell proliferation (PMID:11435302); a lineage-specific, non-core outcome. Supporting Evidence: PMID:11435302 Transfection of normal murine mast cells with kinase-inactive Lyn impaired SCF-induced growth. |
| GO:0071300 cellular response to retinoic acid | IMP PMID:17910947 Identification of twinfilin-2 as a factor involved in neurit... | KEEP AS NON CORE | Summary: Cellular response to retinoic acid. Reason: Reported in a neurite-outgrowth screen context (PMID:17910947); a minor, non-core response. |
| GO:0071345 cellular response to cytokine stimulus | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cellular response to cytokine stimulus. Reason: LYN acts downstream of many cytokine receptors; broad, non-core process (electronic). |
| GO:0071396 cellular response to lipid | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cellular response to lipid. Reason: Electronic (ARBA) transfer; peripheral, non-core. |
| GO:0090025 regulation of monocyte chemotaxis | IMP PMID:18802065 Monocyte migration and LFA-1-mediated attachment to brain mi... | KEEP AS NON CORE | Summary: Regulation of monocyte chemotaxis. Reason: LYN positively regulates SDF-1/CXCR4-driven monocyte migration (PMID:18802065); a downstream, non-core process. Supporting Evidence: PMID:18802065 in SDF-1alpha-stimulated monocytes, Lyn acts as a positive regulator of migration and a negative regulator of adhesion to BMVEC through the LFA-1 integrin |
| GO:0090330 regulation of platelet aggregation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of platelet aggregation. Reason: LYN functions in platelet GPVI/immunoreceptor signaling affecting aggregation (ISS); downstream, non-core. |
| GO:0097028 dendritic cell differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Dendritic cell differentiation. Reason: Downstream myeloid differentiation outcome; non-core. |
| GO:0097028 dendritic cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Dendritic cell differentiation. Reason: Downstream myeloid differentiation outcome; non-core. |
| GO:0097110 scaffold protein binding | IPI PMID:23555801 BANK1 and BLK act through phospholipase C gamma 2 in B-cell ... | KEEP AS NON CORE | Summary: Scaffold protein binding (IPI; BANK1). Reason: LYN binds the B-cell scaffold BANK1 (PMID:23555801); a real interaction reflecting recruitment to BCR signaling scaffolds, kept as non-core. |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: LYN has a conserved neuronal postsynaptic-density localization. Reason: PMID:14529711 directly localizes Lyn among Src-family kinases at excitatory postsynaptic densities and demonstrates PSD-95 binding. Retain the human annotation as a rat-to-human comparative inference; immune predominance does not show loss of the neuronal pool. Supporting Evidence: PMID:14529711 We find that Lck, Lyn, and Yes are localized to the postsynaptic density (PSD), the primary structural component of excitatory synapses. |
| GO:0099091 postsynaptic specialization, intracellular component | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: LYN has a conserved neuronal postsynaptic-density localization. Reason: PMID:14529711 directly localizes Lyn among Src-family kinases at excitatory postsynaptic densities and demonstrates PSD-95 binding. Retain the human annotation as a rat-to-human comparative inference; immune predominance does not show loss of the neuronal pool. Supporting Evidence: PMID:14529711 We find that Lck, Lyn, and Yes are localized to the postsynaptic density (PSD), the primary structural component of excitatory synapses. |
| GO:0120035 regulation of plasma membrane bounded cell projection organization | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Regulation of plasma membrane bounded cell projection organization. Reason: Broad cytoskeletal/projection regulation (ARBA electronic); non-core. |
| GO:0140031 phosphorylation-dependent protein binding | IPI PMID:11782428 BANK regulates BCR-induced calcium mobilization by promoting... | KEEP AS NON CORE | Summary: Phosphorylation-dependent protein binding (IPI; BANK1). Reason: Reflects SH2-mediated recognition of phosphorylated partners (BANK1, PMID:11782428); mechanistically consistent with LYN's SH2 domain, kept as non-core. |
| GO:1902532 negative regulation of intracellular signal transduction | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of intracellular signal transduction. Reason: Captures LYN's inhibitory arm at a general level; non-core. |
| GO:1902993 positive regulation of amyloid precursor protein catabolic process | IMP PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | UNDECIDED | Summary: The positive sign of APP catabolism requires the full turnover experiment. Reason: PMID:24217950 reports accumulation of C99/AICD and control of their ubiquitinβproteasome-dependent turnover without significant gamma-secretase activation. The accessible abstract and publisher supplementary captions do not resolve whether LYN positively regulates intact APP catabolism versus stabilizes particular cleavage products. Retain uncertainty instead of equating increased fragment abundance with increased proteolysis. |
| GO:2000670 positive regulation of dendritic cell apoptotic process | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of dendritic cell apoptotic process. Reason: Downstream dendritic-cell outcome (ISS); non-core. |
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