LYN is a cytoplasmic (non-receptor) protein-tyrosine kinase of the Src family (EC 2.7.10.2), expressed mainly in B-lymphoid, myeloid, mast, platelet and erythroid lineages, with two splice isoforms (p56/LynA and p53/LynB). It has the canonical Src architecture: an N-terminal SH4 region that is N-myristoylated at Gly2 and S-palmitoylated at Cys3, a unique region, SH3 and SH2 domains, a tyrosine-kinase domain, and a C-terminal regulatory tail. Lipidation anchors LYN to the cytoplasmic face of the plasma membrane and enriches it in cholesterol/sphingolipid rafts, where it carries out its principal function; newly synthesized LYN traffics through the Golgi, and a secondary nuclear pool participates in the genotoxic-stress response. LYN catalyses ATP-dependent phosphorylation of tyrosine residues in protein substrates and is autoinhibited by an intramolecular SH2-clamp onto C-terminal phospho-Tyr508 (added by CSK/CHK); activation-loop Tyr397 autophosphorylation and CD45-mediated dephosphorylation of Tyr508 promote the active state. Functionally, LYN is a receptor-proximal signalling switch acting downstream of immunoreceptors (the B-cell receptor via CD79A/CD79B, FcepsilonRI, FcgammaR, CD19, CD22) and of cytokine and growth-factor receptors (KIT, EPOR, MPL, CSF2RB, CXCR4). It phosphorylates activating ITAM motifs to create docking sites for SYK and propagate signalling (PI3K-AKT, BTK-PLCgamma, calcium, MAPK), and it phosphorylates inhibitory ITIM motifs of co-receptors (CD22, FcgammaRIIB, PIR-B, SIRPA) to recruit the phosphatases SHP-1, SHP-2 and SHIP-1, thereby restraining signalling. This dual activating/inhibitory role makes LYN both an initiator and a terminator of immune-cell signalling and a key enforcer of immune self-tolerance; gain-of-function variants that abolish Tyr508 regulation cause a constitutively active-kinase autoinflammatory vasculitis and liver-fibrosis syndrome.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000077 DNA damage checkpoint signaling | IDA PMID:10891478 Role for Lyn tyrosine kinase as a regulator of stress-activa... | KEEP AS NON CORE | Summary: DNA damage checkpoint / genotoxic-stress signaling. Reason: LYN is activated by DNA damage and contributes to the genotoxic-stress signaling/apoptosis response (PMID:10891478, PMID:11517336). A real but non-core, context-specific role secondary to its immunoreceptor function. Supporting Evidence: PMID:10891478 The cellular response to DNA damage includes activation of the nuclear Lyn protein tyrosine kinase. |
| GO:0001782 B cell homeostasis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: B cell homeostasis. Reason: LYN regulates B-cell survival/tolerance thresholds (dual activating/inhibitory role); an important but downstream, non-core physiological outcome of its kinase function. |
| GO:0001817 regulation of cytokine production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of cytokine production. Reason: Downstream consequence of LYN-dependent immune-receptor signaling; non-core. |
| GO:0001932 regulation of protein phosphorylation | TAS PMID:15489917 Src-family kinases in B-cell development and signaling. | KEEP AS NON CORE | Summary: Regulation of protein phosphorylation. Reason: A near-restatement of LYN's kinase activity at the process level; retained as non-core, with the molecular function (GO:0004715) capturing the core. |
| GO:0001933 negative regulation of protein phosphorylation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of protein phosphorylation. Reason: Reflects LYN's inhibitory arm - phosphorylating ITIMs to recruit phosphatases that dephosphorylate signaling kinases. Real but non-core at the process level. |
| GO:0002223 stimulatory C-type lectin receptor signaling pathway | TAS Reactome:R-HSA-5621481 | KEEP AS NON CORE | Summary: Stimulatory C-type lectin receptor signaling pathway. Reason: LYN phosphorylates FcRgamma associated with CLEC receptors (Reactome); a genuine but non-core immunoreceptor branch. |
| GO:0002244 hematopoietic progenitor cell differentiation | IMP PMID:16467205 Integrin inhibition through Lyn-dependent cross talk from CX... | KEEP AS NON CORE | Summary: Hematopoietic progenitor cell differentiation. Reason: Downstream hematopoietic outcome of LYN signaling (PMID:16467205); non-core. Supporting Evidence: PMID:16467205 in chemokine-stimulated hematopoietic cells Lyn kinase is a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta(2) integrins |
| GO:0002431 Fc receptor mediated stimulatory signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Fc receptor mediated stimulatory signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN phosphorylates activating Fc-receptor ITAMs to nucleate SYK-dependent signaling; this is a defining, direct deployment of its kinase activity. IBA node placement is consistent across Src-family kinases. |
| GO:0002431 Fc receptor mediated stimulatory signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Fc receptor mediated stimulatory signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN phosphorylates activating Fc-receptor ITAMs to nucleate SYK-dependent signaling; this is a defining, direct deployment of its kinase activity. IBA node placement is consistent across Src-family kinases. |
| GO:0002513 tolerance induction to self antigen | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Tolerance induction to self antigen. Reason: An important immunological outcome of LYN's inhibitory (ITIM/phosphatase) signaling, but a downstream process rather than a core molecular role; non-core. |
| GO:0002513 tolerance induction to self antigen | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Tolerance induction to self antigen. Reason: An important immunological outcome of LYN's inhibitory (ITIM/phosphatase) signaling, but a downstream process rather than a core molecular role; non-core. |
| GO:0002513 tolerance induction to self antigen | TAS PMID:15489917 Src-family kinases in B-cell development and signaling. | KEEP AS NON CORE | Summary: Tolerance induction to self antigen. Reason: An important immunological outcome of LYN's inhibitory (ITIM/phosphatase) signaling, but a downstream process rather than a core molecular role; non-core. |
| GO:0002553 histamine secretion by mast cell | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Histamine secretion by mast cell. Reason: Downstream mast-cell effector output of FcepsilonRI signaling in which LYN participates; non-core (electronic ortholog transfer). |
| GO:0002576 platelet degranulation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Platelet degranulation. Reason: Downstream platelet effector process; LYN acts in platelet GPVI/immunoreceptor signaling. Non-core. |
| GO:0002758 innate immune response-activating signaling pathway | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Innate immune response-activating signaling pathway. Reason: General innate-immune signaling role consistent with LYN's function in myeloid/TLR signaling; non-core at this level of granularity. |
| GO:0002768 immune response-regulating cell surface receptor signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Immune response-regulating cell surface receptor signaling pathway - the process most directly describing LYN's role. Reason: This process term precisely captures LYN's core biological deployment: transducing signals from immune cell-surface receptors (BCR, FcRs) by phosphorylating their ITAM/ITIM motifs. |
| GO:0002768 immune response-regulating cell surface receptor signaling pathway | TAS PMID:15489917 Src-family kinases in B-cell development and signaling. | ACCEPT | Summary: Immune response-regulating cell surface receptor signaling pathway - the process most directly describing LYN's role. Reason: This process term precisely captures LYN's core biological deployment: transducing signals from immune cell-surface receptors (BCR, FcRs) by phosphorylating their ITAM/ITIM motifs. |
| GO:0002774 Fc receptor mediated inhibitory signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Fc receptor mediated inhibitory signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN phosphorylates inhibitory Fc-receptor (e.g. FcgammaRIIB) ITIMs, recruiting SHP/SHIP phosphatases; this inhibitory arm is a defining, comparatively non-redundant LYN function. |
| GO:0002862 negative regulation of inflammatory response to antigenic stimulus | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Negative regulation of inflammatory response to antigenic stimulus. Reason: Downstream anti-inflammatory outcome of LYN's inhibitory signaling; non-core. |
| GO:0002862 negative regulation of inflammatory response to antigenic stimulus | TAS Reactome:R-HSA-9664323 | KEEP AS NON CORE | Summary: Negative regulation of inflammatory response to antigenic stimulus. Reason: Downstream anti-inflammatory outcome of LYN's inhibitory signaling; non-core. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | ACCEPT | Summary: Protein kinase activity (InterPro-based). Reason: LYN is a bona fide protein kinase; this is a correct, if broad (parent), electronic annotation. The more specific GO:0004715 non-membrane spanning protein tyrosine kinase activity is also annotated and better captures the activity. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:10861086 Differential involvement of Src family kinases in Fc gamma r... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:11110698 Fyn and Lyn phosphorylate the Fc receptor gamma chain downst... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:11358993 Protein kinase C theta is expressed in mast cells and is fun... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:11448999 Vav2 is required for cell spreading. | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:12670955 A lipid raft environment enhances Lyn kinase activity by pro... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:12923167 Tyrosyl phosphorylation of Shp2 is required for normal ERK a... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:1381360 Steel factor stimulates the tyrosine phosphorylation of the ... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:16921024 Differential kinase requirements in human and mouse Fc-gamma... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:18697750 Gab2 is involved in differential phosphoinositide 3-kinase s... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:7526393 Transphosphorylation as the mechanism by which the high-affi... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:8064233 Physical and functional association of the high affinity imm... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:9799234 Kit signaling through PI 3-kinase and Src kinase pathways: a... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:10748115 Substrate recognition by the Lyn protein-tyrosine kinase. NM... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. Supporting Evidence: PMID:10748115 An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:32958780 CD36 facilitates fatty acid uptake by dynamic palmitoylation... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7682714 Identification of HS1 protein as a major substrate of protei... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. Supporting Evidence: PMID:7682714 p75HS1 showed rapid tyrosine phosphorylation and association with a Src-like kinase, Lyn, after crosslinking of membrane-bound IgM. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:36122175 De Novo Gain-Of-Function Variations in LYN Associated With a... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:36932076 Constitutively active Lyn kinase causes a cutaneous small ve... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. Supporting Evidence: PMID:36932076 two de novo truncating variants in the Src-family tyrosine kinase, LYN, p.Y508*, p.Q507* and a de novo missense variant, p.Y508F, that result in constitutive activation of Lyn kinase |
| GO:0004713 protein tyrosine kinase activity | TAS PMID:3561390 The yes-related cellular gene lyn encodes a possible tyrosin... | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-1433506 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-1472121 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-210291 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-2730862 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-388831 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-388833 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-5624486 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-5690702 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9664261 | ACCEPT | Summary: Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN. Reason: LYN (EC 2.7.10.2) catalyses ATP-dependent phosphorylation of protein tyrosine residues; this is its defining catalytic function, supported by extensive biochemistry. The most specific term GO:0004715 (non-membrane spanning PTK activity) is also present. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN. Reason: LYN is a cytoplasmic (non-receptor) Src-family tyrosine kinase. This is the correct, most specific MF term and represents the gene's core function. The IBA node includes P07948 itself among the descendants that ground the ancestral assertion, which is expected experimental support, not circularity. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000003 | ACCEPT | Summary: Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN. Reason: LYN is a cytoplasmic (non-receptor) Src-family tyrosine kinase. This is the correct, most specific MF term and represents the gene's core function. The IBA node includes P07948 itself among the descendants that ground the ancestral assertion, which is expected experimental support, not circularity. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IMP PMID:23555801 BANK1 and BLK act through phospholipase C gamma 2 in B-cell ... | ACCEPT | Summary: Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN. Reason: LYN is a cytoplasmic (non-receptor) Src-family tyrosine kinase. This is the correct, most specific MF term and represents the gene's core function. The IBA node includes P07948 itself among the descendants that ground the ancestral assertion, which is expected experimental support, not circularity. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS Reactome:R-HSA-1168459 | ACCEPT | Summary: Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN. Reason: LYN is a cytoplasmic (non-receptor) Src-family tyrosine kinase. This is the correct, most specific MF term and represents the gene's core function. The IBA node includes P07948 itself among the descendants that ground the ancestral assertion, which is expected experimental support, not circularity. |
| GO:0005102 signaling receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: Signaling receptor binding - LYN docks onto immunoreceptors and cytokine/growth-factor receptors. Reason: LYN binds and phosphorylates immunoreceptors and receptor subunits (CD79A/B, CD22, FcR subunits, KIT, EPOR, CSF2RB) via its SH2/SH3 domains and the kinase; this is a more informative binding term than generic protein binding and is consistent with the IBA node placement across Src-family kinases. |
| GO:0005102 signaling receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: Signaling receptor binding - LYN docks onto immunoreceptors and cytokine/growth-factor receptors. Reason: LYN binds and phosphorylates immunoreceptors and receptor subunits (CD79A/B, CD22, FcR subunits, KIT, EPOR, CSF2RB) via its SH2/SH3 domains and the kinase; this is a more informative binding term than generic protein binding and is consistent with the IBA node placement across Src-family kinases. |
| GO:0005161 platelet-derived growth factor receptor binding | IEA GO_REF:0000107 | REMOVE | Summary: Platelet-derived growth factor receptor binding (electronic transfer from rat ortholog). Reason: This is an over-propagated Ensembl-Compara electronic annotation (GO_REF:0000107, from rat Q07014) asserting a specific receptor-binding activity that is not supported for human LYN; LYN's receptor associations are captured by the more general signaling receptor binding term. Removal does not assert the interaction is impossible, only that this specific electronic MF is unsupported. |
| GO:0005178 integrin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Integrin binding (electronic transfer from rat ortholog). Reason: LYN functions in integrin signaling and regulates integrin activation, so an association is plausible, but direct integrin binding is not a core, human-validated molecular function; kept as non-core. |
| GO:0005515 protein binding | IPI PMID:11306681 Molecular cloning, genomic positioning, promoter identificat... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:11517336 Interaction between growth arrest-DNA damage protein 34 and ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:11782428 BANK regulates BCR-induced calcium mobilization by promoting... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:14993658 The hepatitis C virus NS5A protein binds to members of the S... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:14993658 The hepatitis C virus NS5A protein binds to members of the S... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:14993658 The hepatitis C virus NS5A protein binds to members of the S... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:15546919 ARAP3 is transiently tyrosine phosphorylated in cells attach... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:15784897 Further studies on hepatitis C virus NS5A-SH3 domain interac... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:15784897 Further studies on hepatitis C virus NS5A-SH3 domain interac... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:15784897 Further studies on hepatitis C virus NS5A-SH3 domain interac... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:16155203 Structural characterization of Lyn-SH3 domain in complex wit... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:16374509 Identification of preferred protein interactions by phage-di... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:16799092 Dynamic profiling of the post-translational modifications an... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:1715582 Membrane glycoprotein IV (CD36) is physically associated wit... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:17254966 Cdk-inhibitory activity and stability of p27Kip1 are directl... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:17640867 Leupaxin negatively regulates B cell receptor signaling. | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:18070987 Oncogenic association of the Cbp/PAG adaptor protein with th... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:18070987 Oncogenic association of the Cbp/PAG adaptor protein with th... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:19940238 Molecular priming of Lyn by GPVI enables an immune receptor ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:19940238 Molecular priming of Lyn by GPVI enables an immune receptor ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:20037584 CD36 ligands promote sterile inflammation through assembly o... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:20037584 CD36 ligands promote sterile inflammation through assembly o... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:20159608 Matrix metalloproteinase-9 promotes chronic lymphocytic leuk... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:21930792 SCIMP, a transmembrane adaptor protein involved in major his... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:22581261 DOCK8 functions as an adaptor that links TLR-MyD88 signaling... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:22624718 Tetraspanin CD37 directly mediates transduction of survival ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:22731636 Lyn is involved in CD24-induced ERK1/2 activation in colorec... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:22939624 Quantitative analysis of HSP90-client interactions reveals p... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:23001182 Interactions among HCLS1, HAX1 and LEF-1 proteins are essent... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:23764002 Epidermal growth factor receptor potentiates MCM7-mediated D... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:23764002 Epidermal growth factor receptor potentiates MCM7-mediated D... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:23866081 Lyn, a Src family kinase, regulates activation of epidermal ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:23866081 Lyn, a Src family kinase, regulates activation of epidermal ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:23866081 Lyn, a Src family kinase, regulates activation of epidermal ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:25825872 Preferred SH3 domain partners of ADAM metalloproteases inclu... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:25825872 Preferred SH3 domain partners of ADAM metalloproteases inclu... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:7859737 Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains ... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:8647200 Involvement of p72syk kinase, p53/56lyn kinase and phosphati... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:8753773 Association of CD24 with the kinase c-fgr in a small cell lu... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:9020138 Involvement of p130(Cas) and p105(HEF1), a novel Cas-like do... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005515 protein binding | IPI PMID:9020138 Involvement of p130(Cas) and p105(HEF1), a novel Cas-like do... | REMOVE | Summary: Generic protein binding (IPI) - uninformative molecular-function annotation. Reason: Per curation policy, GO:0005515 protein binding conveys no specific molecular function and is removed as uninformative; the underlying interaction may be genuine but does not describe what LYN does. LYN's informative molecular function is its tyrosine kinase activity (GO:0004715), and specific partner interactions are better captured by kinase substrate relationships or more specific binding terms where warranted. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: ATP binding - required for the kinase reaction. Reason: LYN binds ATP in the catalytic cleft (UniProt: BINDING 253-261, K275). Correct cofactor-binding MF for a protein kinase. |
| GO:0005634 nucleus | IDA PMID:18817770 Nuclear localization of Lyn tyrosine kinase mediated by inhi... | ACCEPT | Summary: Nucleus - a documented secondary pool of LYN, notably in the DNA-damage response. Reason: A nuclear LYN pool is directly demonstrated (PMID:18817770) and is activated in the response to genotoxic stress (PMID:10891478). Accepted, though it is secondary to the plasma-membrane pool. Supporting Evidence: PMID:18817770 Lyn was definitely detected in purified nuclei by immunofluorescence and immunoblotting analyses. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: Nucleus - a documented secondary pool of LYN, notably in the DNA-damage response. Reason: A nuclear LYN pool is directly demonstrated (PMID:18817770) and is activated in the response to genotoxic stress (PMID:10891478). Accepted, though it is secondary to the plasma-membrane pool. |
| GO:0005634 nucleus | ISS GO_REF:0000024 | ACCEPT | Summary: Nucleus - a documented secondary pool of LYN, notably in the DNA-damage response. Reason: A nuclear LYN pool is directly demonstrated (PMID:18817770) and is activated in the response to genotoxic stress (PMID:10891478). Accepted, though it is secondary to the plasma-membrane pool. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: Cytoplasm (broad location). Reason: Correct broad localization for a non-receptor cytoplasmic kinase; retained. |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | ACCEPT | Summary: Cytoplasm (broad location). Reason: Correct broad localization for a non-receptor cytoplasmic kinase; retained. |
| GO:0005765 lysosomal membrane | TAS Reactome:R-HSA-9707977 | KEEP AS NON CORE | Summary: Lysosomal membrane (Reactome TAS; CSF3R degradation reaction compartment). Reason: Recorded as the compartment of a specific Reactome reaction (CSF3R receptor down-modulation). Accurate for that reaction context but not a core LYN location; kept as non-core. |
| GO:0005794 Golgi apparatus | IDA GO_REF:0000052 | ACCEPT | Summary: Golgi apparatus - biosynthetic trafficking compartment for LYN. Reason: Newly synthesized LYN accumulates on the Golgi and is trafficked to the plasma membrane along the secretory pathway (PMID:15173188, PMID:20605918). Well supported. |
| GO:0005794 Golgi apparatus | IDA PMID:15173188 Trafficking of Lyn through the Golgi caveolin involves the c... | ACCEPT | Summary: Golgi apparatus - biosynthetic trafficking compartment for LYN. Reason: Newly synthesized LYN accumulates on the Golgi and is trafficked to the plasma membrane along the secretory pathway (PMID:15173188, PMID:20605918). Well supported. Supporting Evidence: PMID:15173188 biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway |
| GO:0005794 Golgi apparatus | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | ACCEPT | Summary: Golgi apparatus - biosynthetic trafficking compartment for LYN. Reason: Newly synthesized LYN accumulates on the Golgi and is trafficked to the plasma membrane along the secretory pathway (PMID:15173188, PMID:20605918). Well supported. Supporting Evidence: PMID:20605918 After synthesis in the cytoplasm, Lyn accumulates on the Golgi and is subsequently transported to the plasma membrane. |
| GO:0005794 Golgi apparatus | IEA GO_REF:0000044 | ACCEPT | Summary: Golgi apparatus - biosynthetic trafficking compartment for LYN. Reason: Newly synthesized LYN accumulates on the Golgi and is trafficked to the plasma membrane along the secretory pathway (PMID:15173188, PMID:20605918). Well supported. |
| GO:0005829 cytosol | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-114577 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-114600 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1168459 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-139842 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433418 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433428 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433451 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433454 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433456 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433488 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433506 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433514 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433542 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470009 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470010 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470012 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1472121 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1562641 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2029459 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205234 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205238 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205244 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205319 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-210291 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388829 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388831 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388833 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928604 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928607 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928627 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928628 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928642 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928645 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928651 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4093327 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4093336 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-432295 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-437118 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453183 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453200 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5621355 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5624486 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9012657 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9021627 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027272 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027273 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027275 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9027281 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9029150 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664261 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664275 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670412 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670413 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670414 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670416 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670417 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670418 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670426 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9709454 | KEEP AS NON CORE | Summary: Cytosol. Reason: The single IDA is_active_in (PMID:11823534, IL-5 signaling) and the many Reactome TAS rows record cytosol as the compartment of specific signaling reactions. Accurate as a reaction/soluble-pool compartment, but LYN's core catalytic function is executed at the membrane; kept as non-core. The numerous Reactome duplicates are inherent to pathway-reaction annotation and are individually valid. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | IDA PMID:15173188 Trafficking of Lyn through the Golgi caveolin involves the c... | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. Supporting Evidence: PMID:15173188 biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway |
| GO:0005886 plasma membrane | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | IDA PMID:32958780 CD36 facilitates fatty acid uptake by dynamic palmitoylation... | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2454208 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2454240 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730833 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730843 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730851 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730862 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730882 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730884 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730886 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5690702 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9674816 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9677579 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9677585 | ACCEPT | Summary: Plasma membrane (cytoplasmic face) - the principal functional location of LYN. Reason: N-myristoylation (Gly2) and S-palmitoylation (Cys3) target LYN to the cytoplasmic face of the plasma membrane where it acts on clustered receptors. Core location; the IBA is_active_in placement is consistent across Src-family kinases and includes P07948. |
| GO:0005912 adherens junction | IEA GO_REF:0000107 | REMOVE | Summary: Adherens junction (electronic transfer from rat ortholog). Reason: Over-propagated Ensembl-Compara electronic annotation not supported for human LYN; removed. |
| GO:0006468 protein phosphorylation | IDA PMID:11517336 Interaction between growth arrest-DNA damage protein 34 and ... | ACCEPT | Summary: Protein phosphorylation - the process directly effected by LYN's kinase activity. Reason: LYN phosphorylates numerous substrate proteins (e.g. GADD34/PPP1R15A, PMID:11517336); this process is a direct expression of its catalytic function. Supporting Evidence: PMID:11517336 Lyn efficiently phosphorylated affinity-purified GADD34 in vitro. |
| GO:0006468 protein phosphorylation | TAS PMID:3561390 The yes-related cellular gene lyn encodes a possible tyrosin... | ACCEPT | Summary: Protein phosphorylation - the process directly effected by LYN's kinase activity. Reason: LYN phosphorylates numerous substrate proteins (e.g. GADD34/PPP1R15A, PMID:11517336); this process is a direct expression of its catalytic function. |
| GO:0006952 defense response | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Defense response. Reason: Broad immune/defense process consistent with LYN's role in innate and adaptive immunity; retained as non-core. |
| GO:0006954 inflammatory response | IDA PMID:20037584 CD36 ligands promote sterile inflammation through assembly o... | KEEP AS NON CORE | Summary: Inflammatory response. Reason: LYN participates in inflammatory signaling (e.g. CD36-TLR4/6 assembly, PMID:20037584); a genuine but downstream, non-core process. Supporting Evidence: PMID:20037584 these data support a role for CD36-Lyn kinase interactions initiated at Tyr463 in facilitating TLR4-TLR6 heterodimerization and signal initiation |
| GO:0006974 DNA damage response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: DNA damage response. Reason: LYN participates in the response to genotoxic agents (e.g. phosphorylating GADD34/PPP1R15A) (PMID:11517336). Non-core role. The IBA node placement reflects a conserved Src-family involvement. |
| GO:0006974 DNA damage response | IDA PMID:11517336 Interaction between growth arrest-DNA damage protein 34 and ... | KEEP AS NON CORE | Summary: DNA damage response. Reason: LYN participates in the response to genotoxic agents (e.g. phosphorylating GADD34/PPP1R15A) (PMID:11517336). Non-core role. The IBA node placement reflects a conserved Src-family involvement. Supporting Evidence: PMID:11517336 these two proteins physically and functionally interact to regulate DNA damage-induced apoptosis |
| GO:0006991 response to sterol depletion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to sterol depletion. Reason: Electronic ortholog transfer; plausible given raft/cholesterol dependence but peripheral; non-core. |
| GO:0007165 signal transduction | TAS PMID:7650013 G protein-coupled chemoattractant receptors regulate Lyn tyr... | KEEP AS NON CORE | Summary: Signal transduction (broad). Reason: Correct but very general; LYN's specific signaling roles are captured by more granular terms. Non-core. |
| GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Cell surface receptor protein tyrosine kinase signaling pathway. Reason: LYN acts downstream of receptor tyrosine kinases (e.g. KIT, EPOR) as an effector; a real but non-core participation in RTK-initiated pathways. |
| GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway | IMP PMID:14726379 Lyn tyrosine kinase regulates thrombopoietin-induced prolife... | KEEP AS NON CORE | Summary: Cell surface receptor protein tyrosine kinase signaling pathway. Reason: LYN acts downstream of receptor tyrosine kinases (e.g. KIT, EPOR) as an effector; a real but non-core participation in RTK-initiated pathways. |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Positive regulation of cell population proliferation. Reason: Downstream proliferative outcome in several hematopoietic contexts; non-core. |
| GO:0008284 positive regulation of cell population proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of cell population proliferation. Reason: Downstream proliferative outcome in several hematopoietic contexts; non-core. |
| GO:0008285 negative regulation of cell population proliferation | IMP PMID:14726379 Lyn tyrosine kinase regulates thrombopoietin-induced prolife... | KEEP AS NON CORE | Summary: Negative regulation of cell population proliferation. Reason: LYN can restrain proliferation (e.g. thrombopoietin context, PMID:14726379); a context-dependent, non-core outcome reflecting its dualistic role. |
| GO:0009410 response to xenobiotic stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to xenobiotic stimulus. Reason: Electronic ortholog transfer; peripheral, non-core. |
| GO:0009636 response to toxic substance | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to toxic substance. Reason: Electronic ortholog transfer; peripheral, non-core. |
| GO:0009725 response to hormone | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Response to hormone. Reason: Broad response term (ISS ortholog transfer); non-core. |
| GO:0009743 response to carbohydrate | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to carbohydrate. Reason: Electronic ortholog transfer; peripheral, non-core. |
| GO:0009898 cytoplasmic side of plasma membrane | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | ACCEPT | Summary: Cytoplasmic side of plasma membrane - precise functional location. Reason: LYN is anchored to and active at the inner leaflet of the plasma membrane; this is a precise, correct location for its receptor-proximal signaling function. |
| GO:0010976 positive regulation of neuron projection development | IMP PMID:17910947 Identification of twinfilin-2 as a factor involved in neurit... | KEEP AS NON CORE | Summary: Positive regulation of neuron projection development. Reason: Neurite-outgrowth role reported in an RNAi screen context (PMID:17910947); a minor, non-core role for human LYN. |
| GO:0014003 oligodendrocyte development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Oligodendrocyte development. Reason: Electronic ortholog (rodent) transfer of a neural role; non-core for human LYN. |
| GO:0015908 fatty acid transport | IDA PMID:32958780 CD36 facilitates fatty acid uptake by dynamic palmitoylation... | KEEP AS NON CORE | Summary: Fatty acid transport. Reason: LYN acts in CD36 palmitoylation/endocytosis affecting fatty-acid uptake (PMID:32958780), but it regulates rather than performs transport; kept as non-core rather than asserting participation in the transport step itself. |
| GO:0016020 membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Membrane (broad location). Reason: Correct broad membrane association consistent with lipidation-dependent membrane anchoring; retained. |
| GO:0016301 kinase activity | NAS PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | ACCEPT | Summary: Kinase activity (broad parent term). Reason: Correct but non-specific; LYN's activity is captured precisely by GO:0004715. Retained as a true (if general) assertion. |
| GO:0018108 peptidyl-tyrosine phosphorylation | IDA PMID:11782428 BANK regulates BCR-induced calcium mobilization by promoting... | ACCEPT | Summary: Peptidyl-tyrosine phosphorylation - direct expression of LYN kinase activity. Reason: LYN phosphorylates tyrosine residues of substrate proteins (HS1/HCLS1, PMID:7682714; IP3R via BANK, PMID:11782428). Direct catalytic process. Supporting Evidence: PMID:11782428 BANK promotes Lyn-mediated tyrosine phosphorylation of IP(3)R. |
| GO:0018108 peptidyl-tyrosine phosphorylation | IDA PMID:7682714 Identification of HS1 protein as a major substrate of protei... | ACCEPT | Summary: Peptidyl-tyrosine phosphorylation - direct expression of LYN kinase activity. Reason: LYN phosphorylates tyrosine residues of substrate proteins (HS1/HCLS1, PMID:7682714; IP3R via BANK, PMID:11782428). Direct catalytic process. Supporting Evidence: PMID:7682714 p75HS1 showed rapid tyrosine phosphorylation and association with a Src-like kinase, Lyn, after crosslinking of membrane-bound IgM. |
| GO:0019899 enzyme binding | IEA GO_REF:0000107 | REMOVE | Summary: Enzyme binding (electronic transfer from rat ortholog). Reason: Generic, uninformative binding term (like protein binding) that conveys no specific molecular function; removed as uninformative. |
| GO:0030061 mitochondrial crista | IEA GO_REF:0000107 | REMOVE | Summary: Mitochondrial crista (electronic transfer from rat ortholog). Reason: Over-propagated electronic ortholog annotation to a compartment with no support for human LYN biology; removed. |
| GO:0030218 erythrocyte differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Erythrocyte differentiation. Reason: LYN acts downstream of EPOR in erythroid contexts; a downstream, non-core differentiation outcome (ISS). |
| GO:0030222 eosinophil differentiation | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | KEEP AS NON CORE | Summary: Eosinophil differentiation. Reason: LYN associates with IL-5Ralpha and is required for eosinophil differentiation (PMID:11823534); a lineage-specific, non-core outcome. Supporting Evidence: PMID:11823534 Lyn antisense oligodeoxynucleotide blocks eosinophil differentiation from stem cells in a dose-dependent manner. |
| GO:0030546 signaling receptor activator activity | IDA PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | UNDECIDED | Summary: Signaling receptor activator activity (IDA; EphA4/APP pathway). Reason: This molecular-function typing is questionable for a tyrosine kinase (LYN's role is catalytic phosphorylation, not intrinsic receptor-activator activity), and the supporting paper (PMID:24217950) is not available as full text in the cache, so the assay context cannot be verified. Marked UNDECIDED rather than removed, per policy on unverifiable experimental annotations. |
| GO:0030666 endocytic vesicle membrane | TAS Reactome:R-HSA-9705738 | KEEP AS NON CORE | Summary: Endocytic vesicle membrane (Reactome TAS; receptor internalization reactions). Reason: Reaction-compartment annotation from Reactome receptor-endocytosis models; accurate for those reactions but not a core location; kept as non-core. |
| GO:0030666 endocytic vesicle membrane | TAS Reactome:R-HSA-9707977 | KEEP AS NON CORE | Summary: Endocytic vesicle membrane (Reactome TAS; receptor internalization reactions). Reason: Reaction-compartment annotation from Reactome receptor-endocytosis models; accurate for those reactions but not a core location; kept as non-core. |
| GO:0031175 neuron projection development | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Neuron projection development. Reason: IBA node includes a neural-development role across the family; minor and non-core for LYN specifically. |
| GO:0031295 T cell costimulation | TAS Reactome:R-HSA-388841 | KEEP AS NON CORE | Summary: T cell costimulation. Reason: Reactome CD28-family costimulation context; LYN's role in T cells is minor relative to LCK/FYN. Non-core. |
| GO:0031295 T cell costimulation | TAS Reactome:R-HSA-389356 | KEEP AS NON CORE | Summary: T cell costimulation. Reason: Reactome CD28-family costimulation context; LYN's role in T cells is minor relative to LCK/FYN. Non-core. |
| GO:0031625 ubiquitin protein ligase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ubiquitin protein ligase binding (electronic transfer from rat ortholog). Reason: LYN is regulated by ubiquitin ligases (c-Cbl, NEDD4-family via NDFIP1/2) and interacts with them; plausible but peripheral binding activity, kept as non-core. |
| GO:0031663 lipopolysaccharide-mediated signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Lipopolysaccharide-mediated signaling pathway. Reason: LYN modulates LPS/TLR4 signaling in myeloid cells (dual positive/negative); a genuine but non-core process. |
| GO:0031966 mitochondrial membrane | IEA GO_REF:0000107 | REMOVE | Summary: Mitochondrial membrane (electronic transfer from rat ortholog). Reason: Over-propagated electronic ortholog annotation without support for human LYN; removed. |
| GO:0032868 response to insulin | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to insulin. Reason: Electronic ortholog transfer; peripheral, non-core. |
| GO:0033003 regulation of mast cell activation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of mast cell activation. Reason: LYN is a proximal kinase in FcepsilonRI signaling that regulates mast-cell activation (dual role); downstream, non-core process. |
| GO:0033628 regulation of cell adhesion mediated by integrin | IMP PMID:18802065 Monocyte migration and LFA-1-mediated attachment to brain mi... | KEEP AS NON CORE | Summary: Regulation of cell adhesion mediated by integrin. Reason: LYN regulates beta2-integrin (LFA-1) adhesion downstream of chemokine receptors (PMID:18802065, PMID:16467205); a real but non-core process. Supporting Evidence: PMID:18802065 in SDF-1alpha-stimulated monocytes, Lyn acts as a positive regulator of migration and a negative regulator of adhesion to BMVEC through the LFA-1 integrin |
| GO:0034136 negative regulation of toll-like receptor 2 signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of toll-like receptor 2 signaling pathway. Reason: LYN restrains TLR2 signaling in myeloid cells (ISS); non-core. |
| GO:0034144 negative regulation of toll-like receptor 4 signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of toll-like receptor 4 signaling pathway. Reason: Raft-associated LYN negatively regulates LPS/TLR4 signaling; a genuine but non-core (and context-dependent) process. |
| GO:0034145 positive regulation of toll-like receptor 4 signaling pathway | IDA PMID:17392283 Role of TLR4 tyrosine phosphorylation in signal transduction... | KEEP AS NON CORE | Summary: Positive regulation of toll-like receptor 4 signaling pathway. Reason: LYN can also positively regulate TLR4 signaling (TLR4 tyrosine phosphorylation; CD36-TLR4/6 assembly); reflects its dualistic role. Non-core process. |
| GO:0034165 positive regulation of toll-like receptor 9 signaling pathway | IDA PMID:40980882 TLR9 signaling requires ligand-induced phosphorylation of tw... | KEEP AS NON CORE | Summary: Positive regulation of toll-like receptor 9 signaling pathway. Reason: LYN, with Syk and EGFR, phosphorylates and activates TLR9 (PMID:40980882); a genuine but non-core process. Supporting Evidence: PMID:40980882 TLR9 required two Src family of kinases, Syk and Lyn, which, together with EGFR, led to phosphorylation and activation of TLR9 |
| GO:0034605 cellular response to heat | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cellular response to heat. Reason: Electronic ortholog transfer; peripheral, non-core. |
| GO:0034666 integrin alpha2-beta1 complex | IEA GO_REF:0000107 | REMOVE | Summary: Integrin alpha2-beta1 complex membership (electronic transfer from rat ortholog). Reason: Asserts LYN is a subunit of the integrin alpha2-beta1 complex, which is not supported; LYN acts downstream of integrins rather than as a complex component. Over-propagated electronic annotation; removed. |
| GO:0034987 immunoglobulin receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Immunoglobulin receptor binding (electronic transfer from rat ortholog). Reason: Consistent with LYN association with Fc receptors and the BCR complex, but a peripheral binding descriptor rather than a core function; kept as non-core. |
| GO:0035556 intracellular signal transduction | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Intracellular signal transduction. Reason: General signaling role; captured more specifically elsewhere. Non-core. |
| GO:0038043 interleukin-5-mediated signaling pathway | IDA PMID:11823534 Lyn tyrosine kinase is important for IL-5-stimulated eosinop... | KEEP AS NON CORE | Summary: Interleukin-5-mediated signaling pathway. Reason: LYN associates with IL-5Ralpha and phosphorylates it (PMID:11823534); a lineage-specific, non-core signaling branch. Supporting Evidence: PMID:11823534 only Lyn is associated with the IL-5Ralpha under basal conditions |
| GO:0038095 Fc-epsilon receptor signaling pathway | TAS Reactome:R-HSA-2454202 | ACCEPT | Summary: Fc-epsilon receptor signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN phosphorylates the FcepsilonRI beta and gamma ITAMs to initiate mast-cell/basophil signaling; a defining direct role (Reactome; UniProt FUNCTION). |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Fc-gamma receptor signaling pathway involved in phagocytosis. Reason: LYN contributes to FcgammaR-mediated phagocytic signaling in myeloid cells; a genuine but non-core process (partly redundant with other SFKs). |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | TAS Reactome:R-HSA-2029480 | KEEP AS NON CORE | Summary: Fc-gamma receptor signaling pathway involved in phagocytosis. Reason: LYN contributes to FcgammaR-mediated phagocytic signaling in myeloid cells; a genuine but non-core process (partly redundant with other SFKs). |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | TAS Reactome:R-HSA-9664422 | KEEP AS NON CORE | Summary: Fc-gamma receptor signaling pathway involved in phagocytosis. Reason: LYN contributes to FcgammaR-mediated phagocytic signaling in myeloid cells; a genuine but non-core process (partly redundant with other SFKs). |
| GO:0038159 C-X-C chemokine receptor CXCR4 signaling pathway | IMP PMID:16467205 Integrin inhibition through Lyn-dependent cross talk from CX... | KEEP AS NON CORE | Summary: C-X-C chemokine receptor CXCR4 signaling pathway. Reason: LYN mediates CXCR4-driven migration/adhesion crosstalk in hematopoietic cells (PMID:16467205); a real but non-core process. Supporting Evidence: PMID:16467205 in chemokine-stimulated hematopoietic cells Lyn kinase is a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta(2) integrins |
| GO:0042100 B cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: B cell proliferation. Reason: Downstream B-cell outcome of LYN signaling; non-core. |
| GO:0042327 positive regulation of phosphorylation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of phosphorylation. Reason: Process-level restatement of kinase activity (electronic ortholog transfer); non-core. |
| GO:0043015 gamma-tubulin binding | IEA GO_REF:0000107 | REMOVE | Summary: Gamma-tubulin binding (electronic transfer from rat ortholog). Reason: Over-propagated Ensembl-Compara electronic annotation with no support for human LYN; not part of LYN's established biology. Removed. |
| GO:0043200 response to amino acid | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to amino acid. Reason: Electronic ortholog transfer; peripheral, non-core. |
| GO:0043208 glycosphingolipid binding | IEA GO_REF:0000107 | REMOVE | Summary: Glycosphingolipid binding (electronic transfer from rat ortholog). Reason: LYN partitions into sphingolipid/cholesterol-rich rafts via lipidation, but direct glycosphingolipid binding as a molecular function is unsupported and over-propagated; removed (raft localization is captured by GO:0045121). |
| GO:0043304 regulation of mast cell degranulation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of mast cell degranulation. Reason: LYN regulates FcepsilonRI-driven mast-cell degranulation (dual role); downstream, non-core process. |
| GO:0043407 negative regulation of MAP kinase activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of MAP kinase activity. Reason: Reflects LYN's inhibitory arm dampening MAPK signaling in some contexts; non-core. |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:10891478 Role for Lyn tyrosine kinase as a regulator of stress-activa... | KEEP AS NON CORE | Summary: Positive regulation of MAPK cascade (SAPK/JNK in DNA-damage context). Reason: LYN can activate the SAPK/JNK cascade after DNA damage (PMID:10891478); a context-specific, non-core signaling output. Supporting Evidence: PMID:10891478 activation of SAPK by DNA damage is mediated in part by Lyn |
| GO:0043434 response to peptide hormone | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to peptide hormone. Reason: Electronic ortholog transfer; peripheral, non-core. |
| GO:0044325 transmembrane transporter binding | IPI PMID:12538589 Regulation of a transient receptor potential (TRP) channel b... | KEEP AS NON CORE | Summary: Transmembrane transporter binding (IPI; TRPV4 channel). Reason: LYN interacts with and phosphorylates the TRPV4 channel (PMID:12538589); a real but peripheral interaction, kept as non-core. |
| GO:0044325 transmembrane transporter binding | IPI PMID:12538589 Regulation of a transient receptor potential (TRP) channel b... | KEEP AS NON CORE | Summary: Transmembrane transporter binding (IPI; TRPV4 channel). Reason: LYN interacts with and phosphorylates the TRPV4 channel (PMID:12538589); a real but peripheral interaction, kept as non-core. |
| GO:0044877 protein-containing complex binding | IEA GO_REF:0000107 | REMOVE | Summary: Protein-containing complex binding (electronic transfer from rat ortholog). Reason: Generic, uninformative binding term; removed as uninformative. |
| GO:0045121 membrane raft | IDA PMID:11313396 CD24 induces apoptosis in human B cells via the glycolipid-e... | ACCEPT | Summary: Membrane raft - functionally important microdomain localization. Reason: Palmitoylation drives LYN partitioning into cholesterol/sphingolipid-rich rafts, which enhances its activity and its coupling to immunoreceptors. Well supported and functionally significant. Supporting Evidence: PMID:12670955 Cross-linking of IgE-receptor complexes by antigen causes their coalescence with lipid rafts, where they are phosphorylated by the Src family tyrosine kinase, Lyn. |
| GO:0045121 membrane raft | IEA GO_REF:0000117 | ACCEPT | Summary: Membrane raft - functionally important microdomain localization. Reason: Palmitoylation drives LYN partitioning into cholesterol/sphingolipid-rich rafts, which enhances its activity and its coupling to immunoreceptors. Well supported and functionally significant. |
| GO:0045121 membrane raft | ISS GO_REF:0000024 | ACCEPT | Summary: Membrane raft - functionally important microdomain localization. Reason: Palmitoylation drives LYN partitioning into cholesterol/sphingolipid-rich rafts, which enhances its activity and its coupling to immunoreceptors. Well supported and functionally significant. |
| GO:0045646 regulation of erythrocyte differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of erythrocyte differentiation. Reason: LYN acts downstream of EPOR in erythroid maturation; a downstream, non-core regulatory role. |
| GO:0046777 protein autophosphorylation | IDA PMID:7682714 Identification of HS1 protein as a major substrate of protei... | ACCEPT | Summary: Protein autophosphorylation - LYN autophosphorylates its activation loop. Reason: LYN trans-autophosphorylates activation-loop Tyr397, required for optimal catalytic activity (UniProt ACTIVITY REGULATION). Direct expression of its kinase function. |
| GO:0046875 ephrin receptor binding | IPI PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | KEEP AS NON CORE | Summary: Ephrin receptor binding (IPI; EphA4). Reason: LYN interacts with EphA4 in a pathway regulating APP proteolysis (PMID:24217950); a real but context-specific, non-core interaction. |
| GO:0048013 ephrin receptor signaling pathway | IGI PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | KEEP AS NON CORE | Summary: Ephrin receptor signaling pathway. Reason: LYN acts in an EphA4-initiated pathway regulating APP proteolysis (PMID:24217950); a context-specific, non-core process. |
| GO:0048013 ephrin receptor signaling pathway | TAS Reactome:R-HSA-2682334 | KEEP AS NON CORE | Summary: Ephrin receptor signaling pathway. Reason: LYN acts in an EphA4-initiated pathway regulating APP proteolysis (PMID:24217950); a context-specific, non-core process. |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | KEEP AS NON CORE | Summary: Perinuclear region of cytoplasm (IDA/IEA; Golgi-associated pool). Reason: Consistent with the Golgi/perinuclear biosynthetic pool of LYN (PMID:20605918); a real but non-core localization. Supporting Evidence: PMID:20605918 After synthesis in the cytoplasm, Lyn accumulates on the Golgi and is subsequently transported to the plasma membrane. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Perinuclear region of cytoplasm (IDA/IEA; Golgi-associated pool). Reason: Consistent with the Golgi/perinuclear biosynthetic pool of LYN (PMID:20605918); a real but non-core localization. |
| GO:0048678 response to axon injury | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to axon injury. Reason: Electronic ortholog (rodent neural) transfer; non-core for human LYN. |
| GO:0050777 negative regulation of immune response | TAS PMID:15489917 Src-family kinases in B-cell development and signaling. | KEEP AS NON CORE | Summary: Negative regulation of immune response. Reason: Captures LYN's net inhibitory/regulatory role in immunity; a downstream, non-core process. |
| GO:0050855 regulation of B cell receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Regulation of B cell receptor signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN is the principal Src-family kinase initiating and modulating BCR signaling (phosphorylating CD79A/B ITAMs and inhibitory co-receptor ITIMs). Defining, direct role; IBA node includes P07948. |
| GO:0050855 regulation of B cell receptor signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Regulation of B cell receptor signaling pathway - a receptor-proximal process LYN directly executes. Reason: LYN is the principal Src-family kinase initiating and modulating BCR signaling (phosphorylating CD79A/B ITAMs and inhibitory co-receptor ITIMs). Defining, direct role; IBA node includes P07948. |
| GO:0050859 negative regulation of B cell receptor signaling pathway | IDA PMID:35941532 Interfering B cell receptor signaling via SHP-1/p-Lyn axis s... | ACCEPT | Summary: Negative regulation of B cell receptor signaling pathway - LYN's inhibitory arm. Reason: LYN phosphorylates inhibitory co-receptor ITIMs (CD22, FcgammaRIIB) recruiting SHP-1/SHIP-1 to raise the BCR activation threshold (PMID:35941532). A comparatively non-redundant, defining LYN function. Supporting Evidence: PMID:35941532 Lyn appears to play a critical role in B cell receptor signaling due to its dual modulating capacity via activating or inhibiting downstream pathways |
| GO:0050900 leukocyte migration | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Leukocyte migration. Reason: LYN regulates leukocyte/monocyte migration and adhesion (PMID:18802065); a downstream, non-core process. |
| GO:0050900 leukocyte migration | TAS Reactome:R-HSA-202733 | KEEP AS NON CORE | Summary: Leukocyte migration. Reason: LYN regulates leukocyte/monocyte migration and adhesion (PMID:18802065); a downstream, non-core process. |
| GO:0051219 phosphoprotein binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Phosphoprotein binding (electronic transfer from rat ortholog). Reason: Reflects the SH2-domain function of LYN (binding phosphotyrosine-containing proteins); plausible and mechanistically sensible but kept as non-core, as it is an electronic ortholog transfer. |
| GO:0051279 regulation of release of sequestered calcium ion into cytosol | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Regulation of release of sequestered calcium ion into cytosol. Reason: LYN-initiated immunoreceptor signaling feeds calcium mobilization (e.g. via IP3R); electronic ortholog transfer, non-core. |
| GO:0060252 positive regulation of glial cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of glial cell proliferation. Reason: Electronic ortholog (rodent neural) transfer; non-core for human LYN. |
| GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of Fc receptor mediated stimulatory signaling pathway. Reason: Reflects LYN's activating ITAM-phosphorylation role at the regulatory level (electronic ortholog transfer); non-core. |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | TAS Reactome:R-HSA-982772 | KEEP AS NON CORE | Summary: Growth hormone receptor signaling pathway via JAK-STAT. Reason: Reactome cytokine-receptor context (JAK-STAT); LYN participation is peripheral, non-core. |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | KEEP AS NON CORE | Summary: Extracellular exosome (HDA; proteomic detection). Reason: High-throughput proteomic detection in exosome/secretion preparations; not evidence of a functional exosomal role. Kept as non-core. |
| GO:0070372 regulation of ERK1 and ERK2 cascade | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of ERK1 and ERK2 cascade. Reason: LYN modulates ERK signaling downstream of several receptors; a downstream, non-core process. |
| GO:0070373 negative regulation of ERK1 and ERK2 cascade | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of ERK1 and ERK2 cascade. Reason: Reflects LYN's inhibitory arm dampening ERK signaling in some contexts; non-core. |
| GO:0070447 positive regulation of oligodendrocyte progenitor proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of oligodendrocyte progenitor proliferation. Reason: Electronic ortholog (rodent neural) transfer; non-core for human LYN. |
| GO:0070667 negative regulation of mast cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of mast cell proliferation. Reason: Context-dependent negative regulation of mast-cell proliferation (ISS); non-core, reflecting dualistic role. |
| GO:0070668 positive regulation of mast cell proliferation | IMP PMID:11435302 Lyn is required for normal stem cell factor-induced prolifer... | KEEP AS NON CORE | Summary: Positive regulation of mast cell proliferation. Reason: LYN is required for SCF/KIT-induced mast-cell proliferation (PMID:11435302); a lineage-specific, non-core outcome. Supporting Evidence: PMID:11435302 Transfection of normal murine mast cells with kinase-inactive Lyn impaired SCF-induced growth. |
| GO:0071300 cellular response to retinoic acid | IMP PMID:17910947 Identification of twinfilin-2 as a factor involved in neurit... | KEEP AS NON CORE | Summary: Cellular response to retinoic acid. Reason: Reported in a neurite-outgrowth screen context (PMID:17910947); a minor, non-core response. |
| GO:0071345 cellular response to cytokine stimulus | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cellular response to cytokine stimulus. Reason: LYN acts downstream of many cytokine receptors; broad, non-core process (electronic). |
| GO:0071396 cellular response to lipid | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cellular response to lipid. Reason: Electronic (ARBA) transfer; peripheral, non-core. |
| GO:0090025 regulation of monocyte chemotaxis | IMP PMID:18802065 Monocyte migration and LFA-1-mediated attachment to brain mi... | KEEP AS NON CORE | Summary: Regulation of monocyte chemotaxis. Reason: LYN positively regulates SDF-1/CXCR4-driven monocyte migration (PMID:18802065); a downstream, non-core process. Supporting Evidence: PMID:18802065 in SDF-1alpha-stimulated monocytes, Lyn acts as a positive regulator of migration and a negative regulator of adhesion to BMVEC through the LFA-1 integrin |
| GO:0090330 regulation of platelet aggregation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Regulation of platelet aggregation. Reason: LYN functions in platelet GPVI/immunoreceptor signaling affecting aggregation (ISS); downstream, non-core. |
| GO:0097028 dendritic cell differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Dendritic cell differentiation. Reason: Downstream myeloid differentiation outcome; non-core. |
| GO:0097028 dendritic cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Dendritic cell differentiation. Reason: Downstream myeloid differentiation outcome; non-core. |
| GO:0097110 scaffold protein binding | IPI PMID:23555801 BANK1 and BLK act through phospholipase C gamma 2 in B-cell ... | KEEP AS NON CORE | Summary: Scaffold protein binding (IPI; BANK1). Reason: LYN binds the B-cell scaffold BANK1 (PMID:23555801); a real interaction reflecting recruitment to BCR signaling scaffolds, kept as non-core. |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | REMOVE | Summary: Glutamatergic synapse (electronic transfer from rat ortholog). Reason: Over-propagated Ensembl-Compara electronic annotation reflecting rodent neuronal data; not supported as a location for human LYN function; removed. |
| GO:0099091 postsynaptic specialization, intracellular component | IEA GO_REF:0000107 | REMOVE | Summary: Postsynaptic specialization, intracellular component (electronic transfer from rat ortholog). Reason: Over-propagated electronic ortholog annotation without support for human LYN; removed. |
| GO:0120035 regulation of plasma membrane bounded cell projection organization | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Regulation of plasma membrane bounded cell projection organization. Reason: Broad cytoskeletal/projection regulation (ARBA electronic); non-core. |
| GO:0140031 phosphorylation-dependent protein binding | IPI PMID:11782428 BANK regulates BCR-induced calcium mobilization by promoting... | KEEP AS NON CORE | Summary: Phosphorylation-dependent protein binding (IPI; BANK1). Reason: Reflects SH2-mediated recognition of phosphorylated partners (BANK1, PMID:11782428); mechanistically consistent with LYN's SH2 domain, kept as non-core. |
| GO:1902532 negative regulation of intracellular signal transduction | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of intracellular signal transduction. Reason: Captures LYN's inhibitory arm at a general level; non-core. |
| GO:1902993 positive regulation of amyloid precursor protein catabolic process | IMP PMID:24217950 Ligand-dependent activation of EphA4 signaling regulates the... | KEEP AS NON CORE | Summary: Positive regulation of amyloid precursor protein catabolic process. Reason: LYN acts in an EphA4-initiated pathway promoting APP proteolysis (PMID:24217950); a context-specific, non-core process. |
| GO:2000670 positive regulation of dendritic cell apoptotic process | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of dendritic cell apoptotic process. Reason: Downstream dendritic-cell outcome (ISS); non-core. |
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