MAML1

UniProt ID: Q92585
Organism: Homo sapiens
Review Status: INITIALIZED
📝 Provide Detailed Feedback

Gene Description

TODO: Add description for MAML1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005654 nucleoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003713 transcription coactivator activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007221 positive regulation of transcription of Notch receptor target
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003713 transcription coactivator activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007219 Notch signaling pathway
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007221 positive regulation of transcription of Notch receptor target
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016607 nuclear speck
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045944 positive regulation of transcription by RNA polymerase II
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12370315
Identification of a family of mastermind-like transcriptiona... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12370315
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
GO:0005515 protein binding
IPI
PMID:16530044
Structural basis for cooperativity in recruitment of MAML co... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16530044
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
GO:0005515 protein binding
IPI
PMID:18427106
Notch signaling mediates hypoxia-induced tumor cell migratio... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18427106
Notch signaling mediates hypoxia-induced tumor cell migration and invasion.
GO:0005515 protein binding
IPI
PMID:19907488
Direct inhibition of the NOTCH transcription factor complex. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19907488
Direct inhibition of the NOTCH transcription factor complex.
GO:0005515 protein binding
IPI
PMID:20972443
Structural and mechanistic insights into cooperative assembl... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20972443
Oct 24. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.
GO:0005515 protein binding
IPI
PMID:22325781
Conformational locking upon cooperative assembly of notch tr... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22325781
Conformational locking upon cooperative assembly of notch transcription complexes.
GO:0005515 protein binding
IPI
PMID:23022380
NOTCH1 nuclear interactome reveals key regulators of its tra... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23022380
2012 Sep 27. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
GO:0005634 nucleus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010831 positive regulation of myotube differentiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045445 myoblast differentiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051149 positive regulation of muscle cell differentiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060928 atrioventricular node cell development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IDA
PMID:32601208
Pharmacological disruption of the Notch transcription factor... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32601208
Pharmacological disruption of the Notch transcription factor complex.
GO:0007219 Notch signaling pathway
IDA
PMID:32601208
Pharmacological disruption of the Notch transcription factor... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32601208
Pharmacological disruption of the Notch transcription factor complex.
GO:0045893 positive regulation of DNA-templated transcription
IDA
PMID:32601208
Pharmacological disruption of the Notch transcription factor... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32601208
Pharmacological disruption of the Notch transcription factor complex.
GO:0003162 atrioventricular node development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060928 atrioventricular node cell development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-1912394 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-212356 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-2197588 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-2220957 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-2220964 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-2220971 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-2976742 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-4396371 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-4396379 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-4396392 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-4396393 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-4396401 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-4396402 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8878220 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8878237 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9017835 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9018542 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9021406 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9021451 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9021480 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-NUL-2064916 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-NUL-2065178 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-NUL-4396363 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-NUL-9013647 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-NUL-9013660 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-NUL-9013699 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-NUL-9604511 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
IDA
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivat... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
GO:0005515 protein binding
IPI
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivat... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
GO:0005634 nucleus
IDA
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivat... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
GO:0006468 protein phosphorylation
IDA
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivat... 		MODIFY
Summary: MISANNOTATION: MAML1 is a transcriptional coactivator, NOT a kinase. The cited paper PMID:16510869 describes MAML1 as a "coactivator for MEF2C-mediated transcription" and "required for normal myogenesis" - no phosphorylation activity is described. PMID:15546612 shows MAML1 "recruits CycC:CDK8 to phosphorylate the Notch ICD" - meaning MAML1 brings the kinase to its substrate, it doesn't perform phosphorylation itself. UniProt also shows MAML1 is phosphorylated at Ser-314 and Ser-360 (substrate). MAML1's role in phosphorylation is regulatory (recruiting kinases), not catalytic.
Supporting Evidence:
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
GO:0010831 positive regulation of myotube differentiation
IGI
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivat... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
GO:0045944 positive regulation of transcription by RNA polymerase II
IDA
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivat... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
GO:0005515 protein binding
IPI
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a tran... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
GO:0005515 protein binding
IPI
PMID:11390662
A human protein with sequence similarity to Drosophila maste... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11390662
A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters.
GO:0005634 nucleus
IDA
PMID:9874765
CIR, a corepressor linking the DNA binding factor CBF1 to th... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9874765
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
GO:0019901 protein kinase binding
IPI
PMID:15546612
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15546612
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
GO:0042605 peptide antigen binding
IPI
PMID:17317671
The notch regulator MAML1 interacts with p53 and functions a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17317671
2007 Feb 22. The notch regulator MAML1 interacts with p53 and functions as a coactivator.
GO:0003713 transcription coactivator activity
IDA
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a tran... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
GO:0005634 nucleus
IDA
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a tran... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
GO:0007219 Notch signaling pathway
IDA
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a tran... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
GO:0045944 positive regulation of transcription by RNA polymerase II
IDA
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a tran... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:11101851
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
PMID:11390662
A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters.
PMID:12370315
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
PMID:15546612
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
PMID:16510869
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
PMID:16530044
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
PMID:17317671
The notch regulator MAML1 interacts with p53 and functions as a coactivator.
PMID:18427106
Notch signaling mediates hypoxia-induced tumor cell migration and invasion.
PMID:19907488
Direct inhibition of the NOTCH transcription factor complex.
PMID:20972443
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.
PMID:22325781
Conformational locking upon cooperative assembly of notch transcription complexes.
PMID:23022380
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
PMID:32601208
Pharmacological disruption of the Notch transcription factor complex.
PMID:9874765
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
Reactome:R-HSA-1912394
NICD1 in complex with RBPJ (CSL) recruits MAML
Reactome:R-HSA-212356
Formation of CSL-NICD coactivator complex
Reactome:R-HSA-2197588
NICD2 binds RBPJ and MAML in the nucleus
Reactome:R-HSA-2220957
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
Reactome:R-HSA-2220964
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
Reactome:R-HSA-2220971
CDK8 phosphorylates NICD1 PEST domain mutants
Reactome:R-HSA-2976742
NOTCH2 coactivator complex binds FCER2 promoter
Reactome:R-HSA-4396371
NOTCH1 Coactivator Complex binds MYC promoter
Reactome:R-HSA-4396379
NOTCH1 Coactivator Complex binds HES5 promoter
Reactome:R-HSA-4396392
NOTCH1 PEST domain mutants bind HES1 promoter
Reactome:R-HSA-4396393
NOTCH1 PEST domain mutants bind MYC promoter
Reactome:R-HSA-4396401
NOTCH1 PEST domain mutants bind HES5 promoter
Reactome:R-HSA-4396402
NOTCH1 PEST domain mutants bind promoters of HEY genes
Reactome:R-HSA-8878220
RUNX3 binds the NOTCH1 coactivator complex
Reactome:R-HSA-8878237
RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
Reactome:R-HSA-9017835
NOTCH1 coactivator complex binds NOTCH3 gene
Reactome:R-HSA-9018542
NOTCH3 coactivator complex binds DLGAP5 gene promoter
Reactome:R-HSA-9021406
NOTCH3 coactivator complex binds PBX1 gene promoter
Reactome:R-HSA-9021451
NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter
Reactome:R-HSA-9021480
NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter
Reactome:R-NUL-2064916
MAML recruits CDK8:CCNC to xNICD1
Reactome:R-NUL-2065178
CDK8 phosphorylates xNICD1
Reactome:R-NUL-4396363
mNICD1 Chimeric Enhancer Complex binds Hes1 promoter
Reactome:R-NUL-9013647
NICD3 binds RBPJ and MAML in the nucleus
Reactome:R-NUL-9013660
Notch3 coactivator complex binds Hes1 gene promoter
Reactome:R-NUL-9013699
NICD4 binds RBPJ and MAML in the nucleus
Reactome:R-NUL-9604511
Notch4 binds FLT4 gene promoter

📄 View Raw YAML

 
id: Q92585
gene_symbol: MAML1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for MAML1'
existing_annotations:
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003713
      label: transcription coactivator activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007221
      label: positive regulation of transcription of Notch receptor target
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003713
      label: transcription coactivator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007219
      label: Notch signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007221
      label: positive regulation of transcription of Notch receptor target
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016607
      label: nuclear speck
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12370315
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12370315
          supporting_text: Identification of a family of mastermind-like 
            transcriptional coactivators for mammalian notch receptors.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16530044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16530044
          supporting_text: Structural basis for cooperativity in recruitment of 
            MAML coactivators to Notch transcription complexes.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18427106
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18427106
          supporting_text: Notch signaling mediates hypoxia-induced tumor cell 
            migration and invasion.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19907488
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19907488
          supporting_text: Direct inhibition of the NOTCH transcription factor 
            complex.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20972443
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20972443
          supporting_text: Oct 24. Structural and mechanistic insights into 
            cooperative assembly of dimeric Notch transcription complexes.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22325781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22325781
          supporting_text: Conformational locking upon cooperative assembly of 
            notch transcription complexes.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23022380
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23022380
          supporting_text: 2012 Sep 27. NOTCH1 nuclear interactome reveals key 
            regulators of its transcriptional activity and oncogenic function.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010831
      label: positive regulation of myotube differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045445
      label: myoblast differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051149
      label: positive regulation of muscle cell differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060928
      label: atrioventricular node cell development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:32601208
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32601208
          supporting_text: Pharmacological disruption of the Notch transcription
            factor complex.
  - term:
      id: GO:0007219
      label: Notch signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:32601208
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32601208
          supporting_text: Pharmacological disruption of the Notch transcription
            factor complex.
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:32601208
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32601208
          supporting_text: Pharmacological disruption of the Notch transcription
            factor complex.
  - term:
      id: GO:0003162
      label: atrioventricular node development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060928
      label: atrioventricular node cell development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1912394
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-212356
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2197588
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2220957
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2220964
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2220971
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2976742
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-4396371
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-4396379
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-4396392
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-4396393
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-4396401
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-4396402
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8878220
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8878237
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9017835
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9018542
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9021406
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9021451
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9021480
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-NUL-2064916
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-NUL-2065178
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-NUL-4396363
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-NUL-9013647
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-NUL-9013660
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-NUL-9013699
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-NUL-9604511
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002193
      label: MAML1-RBP-Jkappa- ICN1 complex
    evidence_type: IDA
    original_reference_id: PMID:16510869
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16510869
          supporting_text: The Notch coactivator, MAML1, functions as a novel 
            coactivator for MEF2C-mediated transcription and is required for 
            normal myogenesis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16510869
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16510869
          supporting_text: The Notch coactivator, MAML1, functions as a novel 
            coactivator for MEF2C-mediated transcription and is required for 
            normal myogenesis.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:16510869
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16510869
          supporting_text: The Notch coactivator, MAML1, functions as a novel 
            coactivator for MEF2C-mediated transcription and is required for 
            normal myogenesis.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:16510869
    review:
      summary: >-
        MISANNOTATION: MAML1 is a transcriptional coactivator, NOT a kinase. The cited
        paper PMID:16510869 describes MAML1 as a "coactivator for MEF2C-mediated transcription"
        and "required for normal myogenesis" - no phosphorylation activity is described.
        PMID:15546612 shows MAML1 "recruits CycC:CDK8 to phosphorylate the Notch ICD"
        - meaning
        MAML1 brings the kinase to its substrate, it doesn't perform phosphorylation
        itself.
        UniProt also shows MAML1 is phosphorylated at Ser-314 and Ser-360 (substrate).
        MAML1's role in phosphorylation is regulatory (recruiting kinases), not catalytic.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:16510869
          supporting_text: The Notch coactivator, MAML1, functions as a novel 
            coactivator for MEF2C-mediated transcription and is required for 
            normal myogenesis.
  - term:
      id: GO:0010831
      label: positive regulation of myotube differentiation
    evidence_type: IGI
    original_reference_id: PMID:16510869
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16510869
          supporting_text: The Notch coactivator, MAML1, functions as a novel 
            coactivator for MEF2C-mediated transcription and is required for 
            normal myogenesis.
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:16510869
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16510869
          supporting_text: The Notch coactivator, MAML1, functions as a novel 
            coactivator for MEF2C-mediated transcription and is required for 
            normal myogenesis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11101851
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11101851
          supporting_text: MAML1, a human homologue of Drosophila mastermind, is
            a transcriptional co-activator for NOTCH receptors.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11390662
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11390662
          supporting_text: A human protein with sequence similarity to 
            Drosophila mastermind coordinates the nuclear form of notch and a 
            CSL protein to build a transcriptional activator complex on target 
            promoters.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:9874765
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9874765
          supporting_text: CIR, a corepressor linking the DNA binding factor 
            CBF1 to the histone deacetylase complex.
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IPI
    original_reference_id: PMID:15546612
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15546612
          supporting_text: Mastermind recruits CycC:CDK8 to phosphorylate the 
            Notch ICD and coordinate activation with turnover.
  - term:
      id: GO:0042605
      label: peptide antigen binding
    evidence_type: IPI
    original_reference_id: PMID:17317671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17317671
          supporting_text: 2007 Feb 22. The notch regulator MAML1 interacts with
            p53 and functions as a coactivator.
  - term:
      id: GO:0003713
      label: transcription coactivator activity
    evidence_type: IDA
    original_reference_id: PMID:11101851
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11101851
          supporting_text: MAML1, a human homologue of Drosophila mastermind, is
            a transcriptional co-activator for NOTCH receptors.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:11101851
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11101851
          supporting_text: MAML1, a human homologue of Drosophila mastermind, is
            a transcriptional co-activator for NOTCH receptors.
  - term:
      id: GO:0007219
      label: Notch signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:11101851
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11101851
          supporting_text: MAML1, a human homologue of Drosophila mastermind, is
            a transcriptional co-activator for NOTCH receptors.
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:11101851
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11101851
          supporting_text: MAML1, a human homologue of Drosophila mastermind, is
            a transcriptional co-activator for NOTCH receptors.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:11101851
    title: MAML1, a human homologue of Drosophila mastermind, is a 
      transcriptional co-activator for NOTCH receptors.
    findings: []
  - id: PMID:11390662
    title: A human protein with sequence similarity to Drosophila mastermind 
      coordinates the nuclear form of notch and a CSL protein to build a 
      transcriptional activator complex on target promoters.
    findings: []
  - id: PMID:12370315
    title: Identification of a family of mastermind-like transcriptional 
      coactivators for mammalian notch receptors.
    findings: []
  - id: PMID:15546612
    title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and 
      coordinate activation with turnover.
    findings: []
  - id: PMID:16510869
    title: The Notch coactivator, MAML1, functions as a novel coactivator for 
      MEF2C-mediated transcription and is required for normal myogenesis.
    findings: []
  - id: PMID:16530044
    title: Structural basis for cooperativity in recruitment of MAML 
      coactivators to Notch transcription complexes.
    findings: []
  - id: PMID:17317671
    title: The notch regulator MAML1 interacts with p53 and functions as a 
      coactivator.
    findings: []
  - id: PMID:18427106
    title: Notch signaling mediates hypoxia-induced tumor cell migration and 
      invasion.
    findings: []
  - id: PMID:19907488
    title: Direct inhibition of the NOTCH transcription factor complex.
    findings: []
  - id: PMID:20972443
    title: Structural and mechanistic insights into cooperative assembly of 
      dimeric Notch transcription complexes.
    findings: []
  - id: PMID:22325781
    title: Conformational locking upon cooperative assembly of notch 
      transcription complexes.
    findings: []
  - id: PMID:23022380
    title: NOTCH1 nuclear interactome reveals key regulators of its 
      transcriptional activity and oncogenic function.
    findings: []
  - id: PMID:32601208
    title: Pharmacological disruption of the Notch transcription factor complex.
    findings: []
  - id: PMID:9874765
    title: CIR, a corepressor linking the DNA binding factor CBF1 to the histone
      deacetylase complex.
    findings: []
  - id: Reactome:R-HSA-1912394
    title: NICD1 in complex with RBPJ (CSL) recruits MAML
    findings: []
  - id: Reactome:R-HSA-212356
    title: Formation of CSL-NICD coactivator complex
    findings: []
  - id: Reactome:R-HSA-2197588
    title: NICD2 binds RBPJ and MAML in the nucleus
    findings: []
  - id: Reactome:R-HSA-2220957
    title: NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
    findings: []
  - id: Reactome:R-HSA-2220964
    title: NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
    findings: []
  - id: Reactome:R-HSA-2220971
    title: CDK8 phosphorylates NICD1 PEST domain mutants
    findings: []
  - id: Reactome:R-HSA-2976742
    title: NOTCH2 coactivator complex binds FCER2 promoter
    findings: []
  - id: Reactome:R-HSA-4396371
    title: NOTCH1 Coactivator Complex binds MYC promoter
    findings: []
  - id: Reactome:R-HSA-4396379
    title: NOTCH1 Coactivator Complex binds HES5 promoter
    findings: []
  - id: Reactome:R-HSA-4396392
    title: NOTCH1 PEST domain mutants bind HES1 promoter
    findings: []
  - id: Reactome:R-HSA-4396393
    title: NOTCH1 PEST domain mutants bind MYC promoter
    findings: []
  - id: Reactome:R-HSA-4396401
    title: NOTCH1 PEST domain mutants bind HES5 promoter
    findings: []
  - id: Reactome:R-HSA-4396402
    title: NOTCH1 PEST domain mutants bind promoters of HEY genes
    findings: []
  - id: Reactome:R-HSA-8878220
    title: RUNX3 binds the NOTCH1 coactivator complex
    findings: []
  - id: Reactome:R-HSA-8878237
    title: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
    findings: []
  - id: Reactome:R-HSA-9017835
    title: NOTCH1 coactivator complex binds NOTCH3 gene
    findings: []
  - id: Reactome:R-HSA-9018542
    title: NOTCH3 coactivator complex binds DLGAP5 gene promoter
    findings: []
  - id: Reactome:R-HSA-9021406
    title: NOTCH3 coactivator complex binds PBX1 gene promoter
    findings: []
  - id: Reactome:R-HSA-9021451
    title: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter
    findings: []
  - id: Reactome:R-HSA-9021480
    title: NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter
    findings: []
  - id: Reactome:R-NUL-2064916
    title: MAML recruits CDK8:CCNC to xNICD1
    findings: []
  - id: Reactome:R-NUL-2065178
    title: CDK8 phosphorylates xNICD1
    findings: []
  - id: Reactome:R-NUL-4396363
    title: mNICD1 Chimeric Enhancer Complex binds Hes1 promoter
    findings: []
  - id: Reactome:R-NUL-9013647
    title: NICD3 binds RBPJ and MAML in the nucleus
    findings: []
  - id: Reactome:R-NUL-9013660
    title: Notch3 coactivator complex binds Hes1 gene promoter
    findings: []
  - id: Reactome:R-NUL-9013699
    title: NICD4 binds RBPJ and MAML in the nucleus
    findings: []
  - id: Reactome:R-NUL-9604511
    title: Notch4 binds FLT4 gene promoter
    findings: []