MAPK1

UniProt ID: P28482
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for MAPK1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005634 nucleus
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004674 protein serine/threonine kinase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007166 cell surface receptor signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004707 MAP kinase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005524 ATP binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005769 early endosome
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005770 late endosome
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005813 centrosome
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005819 spindle
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005901 caveola
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005925 focal adhesion
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006357 regulation of transcription by RNA polymerase II
IEA
GO_REF:0000108 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007173 epidermal growth factor receptor signaling pathway
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010759 positive regulation of macrophage chemotaxis
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032206 positive regulation of telomere maintenance
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032872 regulation of stress-activated MAPK cascade
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0034198 cellular response to amino acid starvation
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045202 synapse
IEA
GO_REF:0000108 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051403 stress-activated MAPK cascade
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051493 regulation of cytoskeleton organization
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061514 interleukin-34-mediated signaling pathway
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070371 ERK1 and ERK2 cascade
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070849 response to epidermal growth factor
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0072584 caveolin-mediated endocytosis
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090170 regulation of Golgi inheritance
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097542 ciliary tip
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0106310 protein serine kinase activity
IEA
GO_REF:0000116 		PENDING
Summary: TODO: Review this GOA annotation
GO:0120041 positive regulation of macrophage proliferation
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000641 regulation of early endosome to late endosome transport
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:10415025
Direct suppression of TCR-mediated activation of extracellul... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:10601328
A novel regulatory mechanism of MAP kinases activation and n... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12592337
The protein tyrosine phosphatase HePTP regulates nuclear tra... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12840032
Constitutive induction of p-Erk1/2 accompanied by reduced ac... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:15713638
Specific inactivation and nuclear anchoring of extracellular... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16038800
Conditional expression of MAP kinase phosphatase-2 protects ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16286470
Cooperation of ERK and SCFSkp2 for MKP-1 destruction provide... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16288922
New insights into the catalytic activation of the MAPK phosp... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17255944
A MAPK docking site is critical for downregulation of Capicu... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17255949
Mxi2 promotes stimulus-independent ERK nuclear translocation... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18060821
Structural insights into the enzymatic mechanism of the path... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18084305
Structural basis for the catalytic mechanism of phosphothreo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18463290
Human biliverdin reductase is an ERK activator; hBVR is an E... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18616943
Phosphorylation of U24 from Human Herpes Virus type 6 (HHV-6... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19494114
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21826244
TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuc... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21908610
Phosphorylation of the kinase interaction motif in mitogen-a... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21988832
Toward an understanding of the protein interaction network o... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22521293
ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23241949
MEK1 inactivates Myt1 to regulate Golgi membrane fragmentati... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23455922
Interlaboratory reproducibility of large-scale human protein... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23519423
Protein-peptide complex crystallization: a case study on the... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23560844
Metal-dependent protein phosphatase 1A functions as an extra... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23575685
Structure of ERK2 bound to PEA-15 reveals a mechanism for ra... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23584453
Interaction with Shc prevents aberrant Erk activation in the... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23602568
The protein interaction landscape of the human CMGC kinase g... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25241761
Using an in situ proximity ligation assay to systematically ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25852190
Integrative analysis of kinase networks in TRAIL-induced apo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26267535
ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colore... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26733474
Identification of allosteric ERK2 inhibitors through in sili... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:27880917
Phenotypic and Interaction Profiling of the Human Phosphatas... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:29997244
LuTHy: a double-readout bioluminescence-based two-hybrid tec... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:31980649
Extensive rewiring of the EGFR network in colorectal cancer ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32707033
Kinase Interaction Network Expands Functional and Disease Ro... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:34591642
A protein network map of head and neck cancer reveals PIK3CA... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human ce... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:38884001
Mapping adipocyte interactome networks by HaloTag-enrichment... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:9632734
Activation of extracellular signal-regulated kinase 2 by a n... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:9788880
Isolation of the human genes encoding the pyst1 and Pyst2 ph... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding
IPI
PMID:16627622
Direct phosphorylation and regulation of poly(ADP-ribose) po... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding
IPI
PMID:26267534
Small Molecule Inhibition of ERK Dimerization Prevents Tumor... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001784 phosphotyrosine residue binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004674 protein serine/threonine kinase activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008286 insulin receptor signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0014044 Schwann cell development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016301 kinase activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019902 phosphatase binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031143 pseudopodium
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035094 response to nicotine
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038133 ERBB2-ERBB3 signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042552 myelination
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043415 positive regulation of skeletal muscle tissue regeneration
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048009 insulin-like growth factor receptor signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0150078 positive regulation of neuroinflammatory response
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004707 MAP kinase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IDA
PMID:22451653
Siglec-15 protein regulates formation of functional osteocla... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043415 positive regulation of skeletal muscle tissue regeneration
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0106310 protein serine kinase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004674 protein serine/threonine kinase activity
IDA
PMID:35831023
ERK2 MAP kinase regulates SUFU binding by multisite phosphor... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045880 positive regulation of smoothened signaling pathway
IDA
PMID:35831023
ERK2 MAP kinase regulates SUFU binding by multisite phosphor... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004707 MAP kinase activity
TAS
Reactome:R-HSA-111898 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004707 MAP kinase activity
TAS
Reactome:R-HSA-445079 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004674 protein serine/threonine kinase activity
IDA
PMID:38503280
A gut-derived hormone regulates cholesterol metabolism. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070371 ERK1 and ERK2 cascade
IDA
PMID:15850461
The phosphorylation of CapZ-interacting protein (CapZIP) by ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0150078 positive regulation of neuroinflammatory response
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004707 MAP kinase activity
IDA
PMID:38503280
A gut-derived hormone regulates cholesterol metabolism. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070098 chemokine-mediated signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000165 MAPK cascade
IDA
PMID:15850461
The phosphorylation of CapZ-interacting protein (CapZIP) by ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061514 interleukin-34-mediated signaling pathway
IGI
PMID:26754294
miR-28-5p-IL-34-macrophage feedback loop modulates hepatocel... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000165 MAPK cascade
IDA
PMID:24854121
Endophilin-1 regulates blood-brain barrier permeability by c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007173 epidermal growth factor receptor signaling pathway
IDA
PMID:24854121
Endophilin-1 regulates blood-brain barrier permeability by c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26942675
Mitochondria-Translocated PGK1 Functions as a Protein Kinase... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032206 positive regulation of telomere maintenance
IMP
PMID:21531765
High-throughput RNAi screening reveals novel regulators of t... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045542 positive regulation of cholesterol biosynthetic process
IDA
PMID:38503280
A gut-derived hormone regulates cholesterol metabolism. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:11489891
MKP-7, a novel mitogen-activated protein kinase phosphatase,... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32721402
Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IDA
PMID:32721402
Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:32721402
Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32051553
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004674 protein serine/threonine kinase activity
IDA
PMID:7588608
ERF: an ETS domain protein with strong transcriptional repre... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010759 positive regulation of macrophage chemotaxis
IGI
PMID:26754294
miR-28-5p-IL-34-macrophage feedback loop modulates hepatocel... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0120041 positive regulation of macrophage proliferation
IGI
PMID:26754294
miR-28-5p-IL-34-macrophage feedback loop modulates hepatocel... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:15133037
The major vault protein is a novel substrate for the tyrosin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9652816 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005788 endoplasmic reticulum lumen
TAS
Reactome:R-HSA-9636296 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9635739 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004674 protein serine/threonine kinase activity
IDA
PMID:26996940
Regulation of Microtubule Assembly by Tau and not by Pin1. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005901 caveola
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007611 learning or memory
NAS
PMID:11404397
Beta-amyloid activates the mitogen-activated protein kinase ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035094 response to nicotine
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0034198 cellular response to amino acid starvation
IDA
PMID:11096076
Glutamine-dependent antiapoptotic interaction of human gluta... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051403 stress-activated MAPK cascade
IDA
PMID:11096076
Glutamine-dependent antiapoptotic interaction of human gluta... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-6798751 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-6800434 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035578 azurophil granule lumen
TAS
Reactome:R-HSA-6798751 		PENDING
Summary: TODO: Review this GOA annotation
GO:1904813 ficolin-1-rich granule lumen
TAS
Reactome:R-HSA-6800434 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:24735981
MFAP3L activation promotes colorectal cancer cell invasion a... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation
IDA
PMID:23184662
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
HDA
PMID:16791210
Dynamic proteomics in individual human cells uncovers widesp... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
HDA
PMID:16791210
Dynamic proteomics in individual human cells uncovers widesp... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0072686 mitotic spindle
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23847209
Pseudophosphatase STYX modulates cell-fate decisions and cel... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-198746 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-198756 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-199959 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-203797 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-3132737 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-3857329 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-450325 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-5674387 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-5675373 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9032751 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9610166 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9632910 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9725030 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-9765960 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-NUL-9009236 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-109858 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-109862 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-109864 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-111898 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1168459 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-2029469 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-3371531 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-418158 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-418163 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-418170 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-418176 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-418200 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-445079 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5654560 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5654562 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5654565 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5654566 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5672972 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5672973 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5672978 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5672980 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5674130 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5674132 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5674366 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5674373 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5674385 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5674387 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5674496 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5675194 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5675198 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5675206 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5675376 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802910 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802911 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802912 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802914 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802918 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802919 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802921 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802922 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802925 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802926 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802932 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802933 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802934 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802935 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802942 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6802943 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6803227 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6803230 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6803233 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6803234 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6811454 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-6811472 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9610152 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9610153 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9610154 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9610156 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9610166 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9626832 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9627089 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9632910 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9635743 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9636296 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9652165 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9656209 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9656211 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9656214 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9656215 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9657599 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9657603 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9657606 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9657608 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9731111 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9732753 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9734547 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9824582 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9824977 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9825759 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9845033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-NUL-9619973 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038127 ERBB signaling pathway
IDA
PMID:15133037
The major vault protein is a novel substrate for the tyrosin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004674 protein serine/threonine kinase activity
IDA
PMID:18794356
Extracellular signal-regulated kinase 2 (ERK2) phosphorylati... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18794356
Extracellular signal-regulated kinase 2 (ERK2) phosphorylati... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IDA
PMID:18794356
Extracellular signal-regulated kinase 2 (ERK2) phosphorylati... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:18794356
Extracellular signal-regulated kinase 2 (ERK2) phosphorylati... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070849 response to epidermal growth factor
IDA
PMID:18794356
Extracellular signal-regulated kinase 2 (ERK2) phosphorylati... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22253824
Localization of nucleoporin Tpr to the nuclear pore complex ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004674 protein serine/threonine kinase activity
IDA
PMID:15850461
The phosphorylation of CapZ-interacting protein (CapZIP) by ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005769 early endosome
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005770 late endosome
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005856 cytoskeleton
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005901 caveola
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005925 focal adhesion
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032872 regulation of stress-activated MAPK cascade
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051493 regulation of cytoskeleton organization
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0072584 caveolin-mediated endocytosis
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090170 regulation of Golgi inheritance
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000641 regulation of early endosome to late endosome transport
TAS
PMID:19565474
The ERK signaling cascade--views from different subcellular ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
IDA
PMID:16314496
Activation of TRAP/mediator subunit TRAP220/Med1 is regulate... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070371 ERK1 and ERK2 cascade
IDA
PMID:16314496
Activation of TRAP/mediator subunit TRAP220/Med1 is regulate... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019902 phosphatase binding
IPI
PMID:19494114
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004707 MAP kinase activity
TAS
PMID:10706854
Eotaxin induces degranulation and chemotaxis of eosinophils ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006915 apoptotic process
TAS
PMID:10958679
Hsp72-mediated suppression of c-Jun N-terminal kinase is imp... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006935 chemotaxis
TAS
PMID:10706854
Eotaxin induces degranulation and chemotaxis of eosinophils ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
TAS
PMID:1540184
Extracellular signal-regulated kinases in T cells: character... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007268 chemical synaptic transmission
TAS
PMID:10051431
Regulation of extracellular-signal regulated kinase and c-Ju... 		PENDING
Summary: TODO: Review this GOA annotation

References

GO_REF:0000002
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GO_REF:0000024
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GO_REF:0000033
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GO_REF:0000044
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GO_REF:0000052
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GO_REF:0000107
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GO_REF:0000108
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GO_REF:0000116
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GO_REF:0000117
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GO_REF:0000120
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PMID:10051431
Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors.
PMID:10415025
Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.
PMID:10601328
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase.
PMID:10706854
Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.
PMID:10958679
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death.
PMID:11096076
Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1.
PMID:11404397
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer
PMID:11489891
MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein.
PMID:12592337
The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells.
PMID:12840032
Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence.
PMID:15133037
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.
PMID:1540184
Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.
PMID:15713638
Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.
PMID:15850461
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
PMID:16038800
Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.
PMID:16286470
Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.
PMID:16288922
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.
PMID:16314496
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation.
PMID:16627622
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
PMID:16791210
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.
PMID:17255944
A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling.
PMID:17255949
Mxi2 promotes stimulus-independent ERK nuclear translocation.
PMID:18060821
Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase.
PMID:18084305
Structural basis for the catalytic mechanism of phosphothreonine lyase.
PMID:18463290
Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.
PMID:18616943
Phosphorylation of U24 from Human Herpes Virus type 6 (HHV-6) and its potential role in mimicking myelin basic protein (MBP) in multiple sclerosis.
PMID:18794356
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.
PMID:19494114
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.
PMID:19565474
The ERK signaling cascade--views from different subcellular compartments.
PMID:21531765
High-throughput RNAi screening reveals novel regulators of telomerase.
PMID:21826244
TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells.
PMID:21908610
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22253824
Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.
PMID:22451653
Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12).
PMID:22521293
ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells.
PMID:23184662
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.
PMID:23241949
MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells.
PMID:23455922
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
PMID:23519423
Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase.
PMID:23560844
Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase.
PMID:23575685
Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
PMID:23584453
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.
PMID:23602568
The protein interaction landscape of the human CMGC kinase group.
PMID:23847209
Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.
PMID:24735981
MFAP3L activation promotes colorectal cancer cell invasion and metastasis.
PMID:24854121
Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway.
PMID:25241761
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
PMID:25852190
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
PMID:26267534
Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes.
PMID:26267535
ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.
PMID:26733474
Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay.
PMID:26754294
miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis.
PMID:26942675
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.
PMID:26996940
Regulation of Microtubule Assembly by Tau and not by Pin1.
PMID:27880917
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
PMID:29997244
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
PMID:31980649
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
PMID:32051553
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32707033
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
PMID:32721402
Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder within the RASopathy Clinical Spectrum.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:34591642
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human cellular organization.
PMID:35831023
ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.
PMID:38503280
A gut-derived hormone regulates cholesterol metabolism.
PMID:38884001
Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry.
PMID:40205054
Multimodal cell maps as a foundation for structural and functional genomics.
PMID:7588608
ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.
PMID:9632734
Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5.
PMID:9788880
Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.
Reactome:R-HSA-109858
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Reactome:R-HSA-198746
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📄 View Raw YAML

 
id: P28482
gene_symbol: MAPK1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for MAPK1'
alternative_products:
- name: '1'
  id: P28482-1
- name: '2'
  id: P28482-2
  sequence_note: VSP_047815
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007166
    label: cell surface receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005769
    label: early endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005770
    label: late endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005813
    label: centrosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005819
    label: spindle
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005901
    label: caveola
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006357
    label: regulation of transcription by RNA polymerase II
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007173
    label: epidermal growth factor receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010759
    label: positive regulation of macrophage chemotaxis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032206
    label: positive regulation of telomere maintenance
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032872
    label: regulation of stress-activated MAPK cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034198
    label: cellular response to amino acid starvation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045202
    label: synapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051403
    label: stress-activated MAPK cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051493
    label: regulation of cytoskeleton organization
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061514
    label: interleukin-34-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070849
    label: response to epidermal growth factor
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0072584
    label: caveolin-mediated endocytosis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090170
    label: regulation of Golgi inheritance
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097542
    label: ciliary tip
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000116
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0120041
    label: positive regulation of macrophage proliferation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000641
    label: regulation of early endosome to late endosome transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10415025
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10601328
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12592337
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12840032
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15713638
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16038800
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16286470
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16288922
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17255944
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17255949
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18060821
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18084305
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18463290
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18616943
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19494114
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21826244
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21908610
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21988832
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22521293
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23241949
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23455922
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23519423
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23560844
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23575685
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23584453
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23602568
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25241761
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25852190
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26267535
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26733474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27880917
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:29997244
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31980649
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32296183
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32707033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32814053
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:34591642
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35271311
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:38884001
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:40205054
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9632734
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9788880
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:16627622
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:26267534
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001784
    label: phosphotyrosine residue binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008286
    label: insulin receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008353
    label: RNA polymerase II CTD heptapeptide repeat kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0014044
    label: Schwann cell development
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016301
    label: kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019902
    label: phosphatase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031143
    label: pseudopodium
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035094
    label: response to nicotine
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0038133
    label: ERBB2-ERBB3 signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042552
    label: myelination
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043415
    label: positive regulation of skeletal muscle tissue regeneration
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048009
    label: insulin-like growth factor receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0150078
    label: positive regulation of neuroinflammatory response
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:22451653
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043415
    label: positive regulation of skeletal muscle tissue regeneration
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:35831023
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045880
    label: positive regulation of smoothened signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:35831023
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-111898
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-445079
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:38503280
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: IDA
  original_reference_id: PMID:15850461
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0150078
    label: positive regulation of neuroinflammatory response
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:38503280
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070098
    label: chemokine-mediated signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IDA
  original_reference_id: PMID:15850461
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061514
    label: interleukin-34-mediated signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:26754294
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IDA
  original_reference_id: PMID:24854121
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007173
    label: epidermal growth factor receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:24854121
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26942675
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032206
    label: positive regulation of telomere maintenance
  evidence_type: IMP
  original_reference_id: PMID:21531765
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045542
    label: positive regulation of cholesterol biosynthetic process
  evidence_type: IDA
  original_reference_id: PMID:38503280
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11489891
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32721402
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:32721402
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:32721402
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32051553
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:7588608
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010759
    label: positive regulation of macrophage chemotaxis
  evidence_type: IGI
  original_reference_id: PMID:26754294
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0120041
    label: positive regulation of macrophage proliferation
  evidence_type: IGI
  original_reference_id: PMID:26754294
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15133037
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9652816
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005788
    label: endoplasmic reticulum lumen
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9636296
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9635739
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:26996940
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005901
    label: caveola
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007611
    label: learning or memory
  evidence_type: NAS
  original_reference_id: PMID:11404397
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035094
    label: response to nicotine
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034198
    label: cellular response to amino acid starvation
  evidence_type: IDA
  original_reference_id: PMID:11096076
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051403
    label: stress-activated MAPK cascade
  evidence_type: IDA
  original_reference_id: PMID:11096076
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005576
    label: extracellular region
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6798751
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005576
    label: extracellular region
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6800434
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035578
    label: azurophil granule lumen
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6798751
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904813
    label: ficolin-1-rich granule lumen
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6800434
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24735981
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:23184662
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: HDA
  original_reference_id: PMID:16791210
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: HDA
  original_reference_id: PMID:16791210
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0072686
    label: mitotic spindle
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23847209
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-198746
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-198756
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-199959
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-203797
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3132737
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3857329
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-450325
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5674387
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5675373
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9032751
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9610166
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9632910
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9725030
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9765960
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9009236
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-109858
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-109862
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-109864
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-111898
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1168459
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2029469
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3371531
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-418158
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-418163
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-418170
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-418176
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-418200
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-445079
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5654560
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5654562
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5654565
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5654566
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5672972
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5672973
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5672978
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5672980
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5674130
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5674132
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5674366
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5674373
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5674385
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5674387
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5674496
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5675194
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5675198
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5675206
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5675376
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802910
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802911
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802912
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802914
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802918
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802919
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802921
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802922
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802925
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802926
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802932
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802933
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802934
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802935
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802942
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6802943
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6803227
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6803230
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6803233
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6803234
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6811454
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6811472
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9610152
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9610153
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9610154
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9610156
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9610166
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9626832
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9627089
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9632910
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9635743
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9636296
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9652165
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9656209
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9656211
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9656214
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9656215
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9657599
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9657603
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9657606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9657608
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9731111
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9732753
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9734547
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9824582
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9824977
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9825759
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9845033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9619973
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0038127
    label: ERBB signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:15133037
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:18794356
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18794356
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:18794356
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:18794356
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070849
    label: response to epidermal growth factor
  evidence_type: IDA
  original_reference_id: PMID:18794356
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22253824
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:15850461
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005769
    label: early endosome
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005770
    label: late endosome
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005856
    label: cytoskeleton
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005901
    label: caveola
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032872
    label: regulation of stress-activated MAPK cascade
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051493
    label: regulation of cytoskeleton organization
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0072584
    label: caveolin-mediated endocytosis
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090170
    label: regulation of Golgi inheritance
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000641
    label: regulation of early endosome to late endosome transport
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010800
    label: positive regulation of peptidyl-threonine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:16314496
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: IDA
  original_reference_id: PMID:16314496
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019902
    label: phosphatase binding
  evidence_type: IPI
  original_reference_id: PMID:19494114
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008353
    label: RNA polymerase II CTD heptapeptide repeat kinase activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: TAS
  original_reference_id: PMID:10706854
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006915
    label: apoptotic process
  evidence_type: TAS
  original_reference_id: PMID:10958679
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006935
    label: chemotaxis
  evidence_type: TAS
  original_reference_id: PMID:10706854
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007165
    label: signal transduction
  evidence_type: TAS
  original_reference_id: PMID:1540184
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007268
    label: chemical synaptic transmission
  evidence_type: TAS
  original_reference_id: PMID:10051431
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000024
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000033
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000044
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000052
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000107
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000108
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000116
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000117
  title: 'TODO: Fetch title'
  findings: []
- id: GO_REF:0000120
  title: 'TODO: Fetch title'
  findings: []
- id: PMID:10051431
  title: Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine
    receptors.
  findings: []
- id: PMID:10415025
  title: Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine
    phosphatase, a tyrosine-specific phosphatase.
  findings: []
- id: PMID:10601328
  title: A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine
    phosphatase.
  findings: []
- id: PMID:10706854
  title: Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated
    protein kinases.
  findings: []
- id: PMID:10958679
  title: Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent
    cell death.
  findings: []
- id: PMID:11096076
  title: Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating
    kinase 1.
  findings: []
- id: PMID:11404397
  title: 'Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine
    receptors: In vitro and in vivo mechanisms related to Alzheimer'
  findings: []
- id: PMID:11489891
  title: MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein.
  findings: []
- id: PMID:12592337
  title: The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation
    of K562 cells.
  findings: []
- id: PMID:12840032
  title: Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due
    to reactive oxygen species during cellular senescence.
  findings: []
- id: PMID:15133037
  title: The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal
    growth factor signaling.
  findings: []
- id: PMID:1540184
  title: 'Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.'
  findings: []
- id: PMID:15713638
  title: Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity
    protein phosphatase DUSP5.
  findings: []
- id: PMID:15850461
  title: The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation
    from CapZ.
  findings: []
- id: PMID:16038800
  title: Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding
    and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.
  findings: []
- id: PMID:16286470
  title: Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.
  findings: []
- id: PMID:16288922
  title: New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.
  findings: []
- id: PMID:16314496
  title: Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation.
  findings: []
- id: PMID:16627622
  title: Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases
    1/2.
  findings: []
- id: PMID:16791210
  title: Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.
  findings: []
- id: PMID:17255944
  title: A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling.
  findings: []
- id: PMID:17255949
  title: Mxi2 promotes stimulus-independent ERK nuclear translocation.
  findings: []
- id: PMID:18060821
  title: Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase.
  findings: []
- id: PMID:18084305
  title: Structural basis for the catalytic mechanism of phosphothreonine lyase.
  findings: []
- id: PMID:18463290
  title: Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.
  findings: []
- id: PMID:18616943
  title: Phosphorylation of U24 from Human Herpes Virus type 6 (HHV-6) and its potential role in mimicking myelin basic protein
    (MBP) in multiple sclerosis.
  findings: []
- id: PMID:18794356
  title: Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex
    protein Tpr cooperatively regulate ERK2-Tpr interaction.
  findings: []
- id: PMID:19494114
  title: Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2
    kinases.
  findings: []
- id: PMID:19565474
  title: The ERK signaling cascade--views from different subcellular compartments.
  findings: []
- id: PMID:21531765
  title: High-throughput RNAi screening reveals novel regulators of telomerase.
  findings: []
- id: PMID:21826244
  title: TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis
    of colorectal cancer cells.
  findings: []
- id: PMID:21908610
  title: Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates
    cross-talk between protein kinase A and MAP kinase signaling pathways.
  findings: []
- id: PMID:21988832
  title: Toward an understanding of the protein interaction network of the human liver.
  findings: []
- id: PMID:22253824
  title: Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export
    of unspliced RNA.
  findings: []
- id: PMID:22451653
  title: Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa
    (DAP12).
  findings: []
- id: PMID:22521293
  title: ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant
    proximal tubule cells.
  findings: []
- id: PMID:23184662
  title: Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition
    by eEF2 kinase.
  findings: []
- id: PMID:23241949
  title: MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells.
  findings: []
- id: PMID:23455922
  title: Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
  findings: []
- id: PMID:23519423
  title: 'Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase.'
  findings: []
- id: PMID:23560844
  title: Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase.
  findings: []
- id: PMID:23575685
  title: Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
  findings: []
- id: PMID:23584453
  title: Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.
  findings: []
- id: PMID:23602568
  title: The protein interaction landscape of the human CMGC kinase group.
  findings: []
- id: PMID:23847209
  title: Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.
  findings: []
- id: PMID:24735981
  title: MFAP3L activation promotes colorectal cancer cell invasion and metastasis.
  findings: []
- id: PMID:24854121
  title: Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2
    pathway.
  findings: []
- id: PMID:25241761
  title: Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a
    pathway network.
  findings: []
- id: PMID:25852190
  title: Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination
    therapy.
  findings: []
- id: PMID:26267534
  title: Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes.
  findings: []
- id: PMID:26267535
  title: ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.
  findings: []
- id: PMID:26733474
  title: Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay.
  findings: []
- id: PMID:26754294
  title: miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis.
  findings: []
- id: PMID:26942675
  title: Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.
  findings: []
- id: PMID:26996940
  title: Regulation of Microtubule Assembly by Tau and not by Pin1.
  findings: []
- id: PMID:27880917
  title: Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
  findings: []
- id: PMID:29997244
  title: 'LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein
    interactions in mammalian cells.'
  findings: []
- id: PMID:31980649
  title: Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
  findings: []
- id: PMID:32051553
  title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
  findings: []
- id: PMID:32296183
  title: A reference map of the human binary protein interactome.
  findings: []
- id: PMID:32707033
  title: Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
  findings: []
- id: PMID:32721402
  title: Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder within the RASopathy Clinical Spectrum.
  findings: []
- id: PMID:32814053
  title: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation
    in Affected Brains.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
  findings: []
- id: PMID:34591642
  title: A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
  findings: []
- id: PMID:35271311
  title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
  findings: []
- id: PMID:35831023
  title: ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.
  findings: []
- id: PMID:38503280
  title: A gut-derived hormone regulates cholesterol metabolism.
  findings: []
- id: PMID:38884001
  title: Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry.
  findings: []
- id: PMID:40205054
  title: Multimodal cell maps as a foundation for structural and functional genomics.
  findings: []
- id: PMID:7588608
  title: 'ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis
    and is regulated by phosphorylation during cell cycle and mitogenic stimulation.'
  findings: []
- id: PMID:9632734
  title: Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5.
  findings: []
- id: PMID:9788880
  title: 'Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic
    dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.'
  findings: []
- id: Reactome:R-HSA-109858
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- id: Reactome:R-HSA-109862
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- id: Reactome:R-HSA-109864
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- id: Reactome:R-HSA-1168459
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- id: Reactome:R-HSA-198746
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- id: Reactome:R-HSA-198756
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- id: Reactome:R-HSA-199959
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- id: Reactome:R-HSA-2029469
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- id: Reactome:R-HSA-6798751
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  title: 'TODO: Fetch title'
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- id: Reactome:R-HSA-6802926
  title: 'TODO: Fetch title'
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  title: 'TODO: Fetch title'
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  title: 'TODO: Fetch title'
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- id: Reactome:R-HSA-6802934
  title: 'TODO: Fetch title'
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- id: Reactome:R-HSA-6802935
  title: 'TODO: Fetch title'
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- id: Reactome:R-HSA-9032751
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- id: Reactome:R-HSA-9636296
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- id: Reactome:R-HSA-9652165
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- id: Reactome:R-HSA-9652816
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- id: Reactome:R-HSA-9656209
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- id: Reactome:R-HSA-9657603
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- id: Reactome:R-HSA-9657606
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- id: Reactome:R-HSA-9657608
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- id: Reactome:R-HSA-9725030
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- id: Reactome:R-HSA-9731111
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- id: Reactome:R-HSA-9734547
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- id: Reactome:R-HSA-9845033
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- id: Reactome:R-NUL-9009236
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- id: Reactome:R-NUL-9619973
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