MAPT encodes microtubule-associated protein tau, a neuronally enriched, intrinsically disordered microtubule-associated protein. Tau binds tubulin and microtubules through repeat domains, promotes microtubule assembly and stability, and contributes to axonal microtubule organization, axonal transport, neurite/axon development, and neuronal polarity. Tau also associates with neural plasma-membrane and axonal cortex components, and disease-associated phosphorylation or acetylation can alter microtubule and membrane binding. In Alzheimer disease and other tauopathies, modified tau mislocalizes and self-assembles into paired-helical-filament/neurofibrillary-tangle pathology with downstream synaptic, mitochondrial, glial, secretion, and stress-response consequences.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000226 microtubule cytoskeleton organization | IBA GO_REF:0000033 | ACCEPT | Summary: microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0000226 (microtubule cytoskeleton organization), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004857 enzyme inhibitor activity | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: enzyme inhibitor activity is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0004857 (enzyme inhibitor activity), the IBA annotation with qualifier enables from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0008017 microtubule binding | IBA GO_REF:0000033 | ACCEPT | Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0008017 (microtubule binding), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0015630 microtubule cytoskeleton | IBA GO_REF:0000033 | ACCEPT | Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0015630 (microtubule cytoskeleton), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030424 axon | IBA GO_REF:0000033 | ACCEPT | Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030424 (axon), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0060632 regulation of microtubule-based movement | IBA GO_REF:0000033 | ACCEPT | Summary: regulation of microtubule-based movement is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0060632 (regulation of microtubule-based movement), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0140778 microtubule stabilizing activity | IBA GO_REF:0000033 | ACCEPT | Summary: microtubule stabilizing activity is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0140778 (microtubule stabilizing activity), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031175 neuron projection development | IBA GO_REF:0000033 | ACCEPT | Summary: neuron projection development is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031175 (neuron projection development), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005576 extracellular region | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: extracellular region is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005576 (extracellular region), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005829 cytosol | IEA GO_REF:0000044 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005829 (cytosol), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005856 cytoskeleton | IEA GO_REF:0000044 | MARK AS OVER ANNOTATED | Summary: cytoskeleton is a correct but bare parent localization for MAPT. The compartment context that matters to the synthesized core biology - tau microtubule binding, microtubule assembly/stability, and axonal and neuronal projection localization - is already carried by the specific microtubule and tubulin-complex terms, so this parent adds no localization information of its own. Reason: For GO:0005856 (cytoskeleton), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin and microtubules, so the term is not false. It is, however, the bare cytoskeleton parent of terms MAPT already holds from independent evidence, and on its own it names no compartment more precisely than "somewhere in the cytoskeleton". [2026-08 SL project re-review] Uninformative parent from the UniProt subcellular-location pipeline. The sole source for this annotation is GO_REF:0000044 (UniProtKB-SubCell), and the gene already carries strictly more specific term(s) from independent evidence, namely GO:0045298 tubulin complex (IDA) and GO:0005874 microtubule. The term is not false; it is an under-specified location that adds no information over what is already annotated, which is the dominant failure mode of the SL pipeline (see projects/SL.md). Marked over-annotated rather than MODIFY because the more precise term is already present, so there is nothing to replace it with. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0008017 microtubule binding | IEA GO_REF:0000002 | ACCEPT | Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0008017 (microtubule binding), the IEA annotation with qualifier enables from GO_REF:0000002 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0015631 tubulin binding | IEA GO_REF:0000002 | ACCEPT | Summary: tubulin binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0015631 (tubulin binding), the IEA annotation with qualifier enables from GO_REF:0000002 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030424 axon | IEA GO_REF:0000044 | ACCEPT | Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030424 (axon), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030425 dendrite | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: dendrite is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030425 (dendrite), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1904115 axon cytoplasm | IEA GO_REF:0000108 | ACCEPT | Summary: axon cytoplasm is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1904115 (axon cytoplasm), the IEA annotation with qualifier located_in from GO_REF:0000108 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:16275660 Identification of VCP/p97, carboxyl terminus of Hsp70-intera... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16275660 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:16446437 Abeta and tau form soluble complexes that may promote self a... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16446437 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17317006 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylatio... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17317006 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:18292230 Akt and CHIP coregulate tau degradation through coordinated ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18292230 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19138662 Effect of phosphorylation on interaction of human tau protei... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19138662 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19527721 Excitatory amino acid transporter 2 associates with phosphor... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19527721 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19647741 Phosphorylation of more than one site is required for tight ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19647741 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21692989 Tyrosine phosphorylation of tau regulates its interactions w... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21692989 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:24028865 Impact of the cellular prion protein on amyloid-Ξ² and 3PO-ta... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24028865 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:25156556 AlphaScreen HTS and live-cell bioluminescence resonance ener... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25156556 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:26402096 Identification of Novel Tau Interactions with Endoplasmic Re... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26402096 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:28650319 Somatostatin binds to the human amyloid Ξ² peptide and favors... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28650319 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:29764935 The disorderly conduct of Hsc70 and its interaction with the... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:29764935 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:30668577 Role of tau N-terminal motif in the secretion of human tau b... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:30668577 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:31640277 GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:31640277 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:32814053 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:33961781 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:34757590 Targeting Tau Mitigates Mitochondrial Fragmentation and Oxid... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:34757590 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:7566652 ApoE3 binding to tau tandem repeat I is abolished by tau ser... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:7566652 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0042802 identical protein binding | IPI PMID:16446437 Abeta and tau form soluble complexes that may promote self a... | ACCEPT | Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0042802 (identical protein binding), the IPI annotation with qualifier enables from PMID:16446437 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0042802 identical protein binding | IPI PMID:30158706 Structures of filaments from Pick's disease reveal a novel t... | ACCEPT | Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0042802 (identical protein binding), the IPI annotation with qualifier enables from PMID:30158706 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0042802 identical protein binding | IPI PMID:30894745 Novel tau filament fold in chronic traumatic encephalopathy ... | ACCEPT | Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0042802 (identical protein binding), the IPI annotation with qualifier enables from PMID:30894745 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from GO_REF:0000052 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005576 extracellular region | EXP PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | KEEP AS NON CORE | Summary: extracellular region is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005576 (extracellular region), the EXP annotation with qualifier located_in from PMID:32272059 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004857 enzyme inhibitor activity | IDA PMID:19457097 Tau--an inhibitor of deacetylase HDAC6 function. | KEEP AS NON CORE | Summary: enzyme inhibitor activity is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0004857 (enzyme inhibitor activity), the IDA annotation with qualifier enables from PMID:19457097 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0060632 regulation of microtubule-based movement | IGI PMID:19457097 Tau--an inhibitor of deacetylase HDAC6 function. | ACCEPT | Summary: regulation of microtubule-based movement is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0060632 (regulation of microtubule-based movement), the IGI annotation with qualifier involved_in from PMID:19457097 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0019901 protein kinase binding | IPI PMID:25556849 A novel DYRK1A (dual specificity tyrosine phosphorylation-re... | KEEP AS NON CORE | Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables from PMID:25556849 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9836404 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-9836404 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0003779 actin binding | TAS PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... | KEEP AS NON CORE | Summary: actin binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003779 (actin binding), the TAS annotation with qualifier enables from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032930 positive regulation of superoxide anion generation | IMP PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... | KEEP AS NON CORE | Summary: positive regulation of superoxide anion generation is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0032930 (positive regulation of superoxide anion generation), the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0090258 negative regulation of mitochondrial fission | IMP PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... | KEEP AS NON CORE | Summary: negative regulation of mitochondrial fission is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0090258 (negative regulation of mitochondrial fission), the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0019901 protein kinase binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019901 (protein kinase binding), the ISS annotation with qualifier enables from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0051087 protein-folding chaperone binding | IPI PMID:25051234 Intracellular clusterin interacts with brain isoforms of the... | KEEP AS NON CORE | Summary: protein-folding chaperone binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0051087 (protein-folding chaperone binding), the IPI annotation with qualifier enables from PMID:25051234 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0019899 enzyme binding | ISS PMID:23362255 Isomerase Pin1 stimulates dephosphorylation of tau protein a... | MARK AS OVER ANNOTATED | Summary: enzyme binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019899 (enzyme binding), the ISS annotation with qualifier enables from PMID:23362255 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0042802 identical protein binding | IPI PMID:27044754 FRMD4A-cytohesin signaling modulates the cellular release of... | ACCEPT | Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0042802 (identical protein binding), the IPI annotation with qualifier enables from PMID:27044754 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0042802 identical protein binding | IDA PMID:15654759 Residual structure in the repeat domain of tau: echoes of mi... | ACCEPT | Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0042802 (identical protein binding), the IDA annotation with qualifier enables from PMID:15654759 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0097435 supramolecular fiber organization | IDA PMID:15654759 Residual structure in the repeat domain of tau: echoes of mi... | ACCEPT | Summary: supramolecular fiber organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0097435 (supramolecular fiber organization), the IDA annotation with qualifier involved_in from PMID:15654759 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:22367970 Abnormal interaction between the mitochondrial fission prote... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22367970 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0019901 protein kinase binding | IPI PMID:16923168 Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase c... | KEEP AS NON CORE | Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables from PMID:16923168 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005737 cytoplasm | IMP PMID:27044754 FRMD4A-cytohesin signaling modulates the cellular release of... | KEEP AS NON CORE | Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005737 (cytoplasm), the IMP annotation with qualifier located_in from PMID:27044754 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0051258 protein polymerization | IMP PMID:27044754 FRMD4A-cytohesin signaling modulates the cellular release of... | ACCEPT | Summary: protein polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0051258 (protein polymerization), the IMP annotation with qualifier involved_in from PMID:27044754 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:26014385 LRRK2 Promotes Tau Accumulation, Aggregation and Release. | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26014385 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005737 cytoplasm | IMP PMID:26014385 LRRK2 Promotes Tau Accumulation, Aggregation and Release. | KEEP AS NON CORE | Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005737 (cytoplasm), the IMP annotation with qualifier located_in from PMID:26014385 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0042802 identical protein binding | IMP PMID:26014385 LRRK2 Promotes Tau Accumulation, Aggregation and Release. | ACCEPT | Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0042802 (identical protein binding), the IMP annotation with qualifier enables from PMID:26014385 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-9619534 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-NUL-9619534 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-9619539 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-NUL-9619539 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:24251416 Phosphorylation of human Tau protein by microtubule affinity... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24251416 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0019901 protein kinase binding | IPI PMID:24251416 Phosphorylation of human Tau protein by microtubule affinity... | KEEP AS NON CORE | Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables from PMID:24251416 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0015630 microtubule cytoskeleton | NAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | ACCEPT | Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0015630 (microtubule cytoskeleton), the NAS annotation with qualifier located_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0015630 microtubule cytoskeleton | IDA PMID:28377597 Dyrk1A overexpression leads to increase of 3R-tau expression... | ACCEPT | Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier located_in from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0015630 microtubule cytoskeleton | NAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0015630 (microtubule cytoskeleton), the NAS annotation with qualifier located_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:23666762 Role of individual MARK isoforms in phosphorylation of tau a... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23666762 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005737 cytoplasm | IDA PMID:23666762 Role of individual MARK isoforms in phosphorylation of tau a... | KEEP AS NON CORE | Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:23666762 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030425 dendrite | IDA PMID:23666762 Role of individual MARK isoforms in phosphorylation of tau a... | KEEP AS NON CORE | Summary: dendrite is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030425 (dendrite), the IDA annotation with qualifier located_in from PMID:23666762 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0044297 cell body | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: cell body is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0044297 (cell body), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0045121 membrane raft | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: membrane raft is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0045121 (membrane raft), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0097386 glial cell projection | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: glial cell projection is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0097386 (glial cell projection), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:28755476 Regulation of the interaction between the neuronal BIN1 isof... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28755476 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005737 (cytoplasm), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0008017 microtubule binding | TAS PMID:26609151 Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transp... | ACCEPT | Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0008017 (microtubule binding), the TAS annotation with qualifier enables from PMID:26609151 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0044304 main axon | ISS GO_REF:0000024 | ACCEPT | Summary: main axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0044304 (main axon), the ISS annotation with qualifier located_in from GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0061564 axon development | TAS PMID:26609151 Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transp... | ACCEPT | Summary: axon development is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0061564 (axon development), the TAS annotation with qualifier involved_in from PMID:26609151 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0051879 Hsp90 protein binding | IPI PMID:17517623 Roles of heat-shock protein 90 in maintaining and facilitati... | KEEP AS NON CORE | Summary: Hsp90 protein binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0051879 (Hsp90 protein binding), the IPI annotation with qualifier enables from PMID:17517623 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:25051234 Intracellular clusterin interacts with brain isoforms of the... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25051234 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0046785 microtubule polymerization | TAS PMID:26996940 Regulation of Microtubule Assembly by Tau and not by Pin1. | ACCEPT | Summary: microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0046785 (microtubule polymerization), the TAS annotation with qualifier involved_in from PMID:26996940 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0019901 protein kinase binding | ISS PMID:17906291 DYRK1A-mediated hyperphosphorylation of Tau. A functional li... | KEEP AS NON CORE | Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019901 (protein kinase binding), the ISS annotation with qualifier enables from PMID:17906291 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0003677 DNA binding | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003677 (DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0003680 minor groove of adenine-thymine-rich DNA binding | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: minor groove of adenine-thymine-rich DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003680 (minor groove of adenine-thymine-rich DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0003690 double-stranded DNA binding | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: double-stranded DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003690 (double-stranded DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0003697 single-stranded DNA binding | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: single-stranded DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003697 (single-stranded DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0003723 RNA binding | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: RNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003723 (RNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0003779 actin binding | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: actin binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003779 (actin binding), the TAS annotation with qualifier enables from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005576 extracellular region | NAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: extracellular region is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005576 (extracellular region), the NAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005634 nucleus | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: nucleus is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005634 (nucleus), the TAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005739 mitochondrion | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: mitochondrion is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005739 (mitochondrion), the TAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005886 plasma membrane | TAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0007267 cell-cell signaling | NAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: cell-cell signaling is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0007267 (cell-cell signaling), the NAS annotation with qualifier involved_in from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0008017 microtubule binding | NAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0008017 (microtubule binding), the NAS annotation with qualifier enables from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0016072 rRNA metabolic process | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: rRNA metabolic process is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0016072 (rRNA metabolic process), the TAS annotation with qualifier involved_in from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0021954 central nervous system neuron development | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: central nervous system neuron development is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0021954 (central nervous system neuron development), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030424 axon | TAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030424 (axon), the TAS annotation with qualifier located_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030674 protein-macromolecule adaptor activity | TAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: protein-macromolecule adaptor activity is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030674 (protein-macromolecule adaptor activity), the TAS annotation with qualifier enables from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031113 regulation of microtubule polymerization | TAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031113 (regulation of microtubule polymerization), the TAS annotation with qualifier involved_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0033044 regulation of chromosome organization | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: regulation of chromosome organization is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0033044 (regulation of chromosome organization), the TAS annotation with qualifier involved_in from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0034063 stress granule assembly | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: stress granule assembly is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0034063 (stress granule assembly), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0034614 cellular response to reactive oxygen species | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: cellular response to reactive oxygen species is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0034614 (cellular response to reactive oxygen species), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0035091 phosphatidylinositol binding | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: phosphatidylinositol binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0035091 (phosphatidylinositol binding), the TAS annotation with qualifier enables from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0036477 somatodendritic compartment | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: somatodendritic compartment is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0036477 (somatodendritic compartment), the TAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0043197 dendritic spine | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: dendritic spine is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0043197 (dendritic spine), the TAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0043565 sequence-specific DNA binding | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: sequence-specific DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0043565 (sequence-specific DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0048167 regulation of synaptic plasticity | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: regulation of synaptic plasticity is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0048167 (regulation of synaptic plasticity), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0070507 regulation of microtubule cytoskeleton organization | TAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: regulation of microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0070507 (regulation of microtubule cytoskeleton organization), the TAS annotation with qualifier involved_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0099077 histone-dependent DNA binding | TAS PMID:28386764 Roles of tau protein in health and disease. | MARK AS OVER ANNOTATED | Summary: histone-dependent DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0099077 (histone-dependent DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:1900452 regulation of long-term synaptic depression | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: regulation of long-term synaptic depression is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1900452 (regulation of long-term synaptic depression), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1902936 phosphatidylinositol bisphosphate binding | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: phosphatidylinositol bisphosphate binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1902936 (phosphatidylinositol bisphosphate binding), the TAS annotation with qualifier enables from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1990090 cellular response to nerve growth factor stimulus | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: cellular response to nerve growth factor stimulus is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1990090 (cellular response to nerve growth factor stimulus), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1990416 cellular response to brain-derived neurotrophic factor stimulus | TAS PMID:28386764 Roles of tau protein in health and disease. | KEEP AS NON CORE | Summary: cellular response to brain-derived neurotrophic factor stimulus is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1990416 (cellular response to brain-derived neurotrophic factor stimulus), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010288 response to lead ion | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: response to lead ion is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0010288 (response to lead ion), the ISS annotation with qualifier involved_in from GO_REF:0000024 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0050848 regulation of calcium-mediated signaling | IDA PMID:18272392 Extracellular tau promotes intracellular calcium increase th... | KEEP AS NON CORE | Summary: regulation of calcium-mediated signaling is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0050848 (regulation of calcium-mediated signaling), the IDA annotation with qualifier involved_in from PMID:18272392 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:3111527 Comparison of S100b protein with calmodulin: interactions wi... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:3111527 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0031113 regulation of microtubule polymerization | TAS PMID:10640627 Regulation of phosphorylation of neuronal microtubule-associ... | ACCEPT | Summary: regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031113 (regulation of microtubule polymerization), the TAS annotation with qualifier involved_in from PMID:10640627 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0000226 microtubule cytoskeleton organization | NAS PMID:28377597 Dyrk1A overexpression leads to increase of 3R-tau expression... | ACCEPT | Summary: microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0000226 (microtubule cytoskeleton organization), the NAS annotation with qualifier involved_in from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0008017 microtubule binding | IDA PMID:28377597 Dyrk1A overexpression leads to increase of 3R-tau expression... | ACCEPT | Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0008017 (microtubule binding), the IDA annotation with qualifier enables from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0098930 axonal transport | NAS PMID:28377597 Dyrk1A overexpression leads to increase of 3R-tau expression... | ACCEPT | Summary: axonal transport is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0098930 (axonal transport), the NAS annotation with qualifier involved_in from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005874 microtubule | ISS GO_REF:0000024 | ACCEPT | Summary: microtubule is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005874 (microtubule), the ISS annotation with qualifier colocalizes_with from GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0010629 negative regulation of gene expression | IMP PMID:23164821 Clusterin regulates Ξ²-amyloid toxicity via Dickkopf-1-driven... | MARK AS OVER ANNOTATED | Summary: negative regulation of gene expression is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0010629 (negative regulation of gene expression), the IMP annotation with qualifier involved_in from PMID:23164821 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20655099 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0007613 memory | IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... | KEEP AS NON CORE | Summary: memory is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0007613 (memory), the IMP annotation with qualifier involved_in from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0016020 membrane | IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... | KEEP AS NON CORE | Summary: membrane is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0016020 (membrane), the IMP annotation with qualifier colocalizes_with from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0036477 somatodendritic compartment | IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... | KEEP AS NON CORE | Summary: somatodendritic compartment is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0036477 (somatodendritic compartment), the IMP annotation with qualifier located_in from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0043025 neuronal cell body | IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... | KEEP AS NON CORE | Summary: neuronal cell body is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0043025 (neuronal cell body), the IMP annotation with qualifier located_in from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0050808 synapse organization | IMP PMID:17270732 Synapse loss and microglial activation precede tangles in a ... | KEEP AS NON CORE | Summary: synapse organization is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0050808 (synapse organization), the IMP annotation with qualifier involved_in from PMID:17270732 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1902474 positive regulation of protein localization to synapse | IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... | KEEP AS NON CORE | Summary: positive regulation of protein localization to synapse is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1902474 (positive regulation of protein localization to synapse), the IMP annotation with qualifier involved_in from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0003677 DNA binding | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003677 (DNA binding), the ISS annotation with qualifier enables from GO_REF:0000024 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005634 nucleus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: nucleus is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005634 (nucleus), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005829 cytosol | ISS GO_REF:0000024 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005829 (cytosol), the ISS annotation with qualifier located_in from GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006974 DNA damage response | IMP PMID:21131359 Nuclear tau, a key player in neuronal DNA protection. | KEEP AS NON CORE | Summary: DNA damage response is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0006974 (DNA damage response), the IMP annotation with qualifier involved_in from PMID:21131359 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010917 negative regulation of mitochondrial membrane potential | IMP PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... | KEEP AS NON CORE | Summary: negative regulation of mitochondrial membrane potential is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0010917 (negative regulation of mitochondrial membrane potential), the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0090140 regulation of mitochondrial fission | IC PMID:22367970 Abnormal interaction between the mitochondrial fission prote... | KEEP AS NON CORE | Summary: regulation of mitochondrial fission is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0090140 (regulation of mitochondrial fission), the IC annotation with qualifier involved_in from PMID:22367970 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1900034 regulation of cellular response to heat | IMP PMID:21131359 Nuclear tau, a key player in neuronal DNA protection. | KEEP AS NON CORE | Summary: regulation of cellular response to heat is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1900034 (regulation of cellular response to heat), the IMP annotation with qualifier involved_in from PMID:21131359 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1903748 negative regulation of protein localization to mitochondrion | IMP PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... | KEEP AS NON CORE | Summary: negative regulation of protein localization to mitochondrion is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1903748 (negative regulation of protein localization to mitochondrion), the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0048312 intracellular distribution of mitochondria | IMP PMID:21854751 Tau accumulation causes mitochondrial distribution deficits ... | KEEP AS NON CORE | Summary: intracellular distribution of mitochondria is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0048312 (intracellular distribution of mitochondria), the IMP annotation with qualifier involved_in from PMID:21854751 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0001774 microglial cell activation | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | KEEP AS NON CORE | Summary: microglial cell activation is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0001774 (microglial cell activation), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0003779 actin binding | TAS PMID:27306859 Tau physiology and pathomechanisms in frontotemporal lobar d... | KEEP AS NON CORE | Summary: actin binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0003779 (actin binding), the TAS annotation with qualifier enables from PMID:27306859 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0008017 microtubule binding | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | ACCEPT | Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0008017 (microtubule binding), the TAS annotation with qualifier enables from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0019896 axonal transport of mitochondrion | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | KEEP AS NON CORE | Summary: axonal transport of mitochondrion is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019896 (axonal transport of mitochondrion), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030424 axon | NAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | ACCEPT | Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030424 (axon), the NAS annotation with qualifier located_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031122 cytoplasmic microtubule organization | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | ACCEPT | Summary: cytoplasmic microtubule organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031122 (cytoplasmic microtubule organization), the TAS annotation with qualifier involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031175 neuron projection development | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | ACCEPT | Summary: neuron projection development is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031175 (neuron projection development), the TAS annotation with qualifier involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0034452 dynactin binding | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | KEEP AS NON CORE | Summary: dynactin binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0034452 (dynactin binding), the TAS annotation with qualifier enables from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0034605 cellular response to heat | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | KEEP AS NON CORE | Summary: cellular response to heat is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0034605 (cellular response to heat), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0048143 astrocyte activation | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | KEEP AS NON CORE | Summary: astrocyte activation is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0048143 (astrocyte activation), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0051721 protein phosphatase 2A binding | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | KEEP AS NON CORE | Summary: protein phosphatase 2A binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0051721 (protein phosphatase 2A binding), the TAS annotation with qualifier enables from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0072386 plus-end-directed organelle transport along microtubule | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | KEEP AS NON CORE | Summary: plus-end-directed organelle transport along microtubule is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0072386 (plus-end-directed organelle transport along microtubule), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0098930 axonal transport | TAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | ACCEPT | Summary: axonal transport is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0098930 (axonal transport), the TAS annotation with qualifier involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1902988 neurofibrillary tangle assembly | NAS PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... | ACCEPT | Summary: neurofibrillary tangle assembly is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1902988 (neurofibrillary tangle assembly), the NAS annotation with qualifier involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | IDA PMID:27356871 Acetylated tau destabilizes the cytoskeleton in the axon ini... | KEEP AS NON CORE | Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:27356871 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0015630 microtubule cytoskeleton | IDA PMID:27356871 Acetylated tau destabilizes the cytoskeleton in the axon ini... | ACCEPT | Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier located_in from PMID:27356871 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031110 regulation of microtubule polymerization or depolymerization | IMP PMID:27356871 Acetylated tau destabilizes the cytoskeleton in the axon ini... | ACCEPT | Summary: regulation of microtubule polymerization or depolymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031110 (regulation of microtubule polymerization or depolymerization), the IMP annotation with qualifier involved_in from PMID:27356871 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1903829 positive regulation of protein localization | IMP PMID:27356871 Acetylated tau destabilizes the cytoskeleton in the axon ini... | MARK AS OVER ANNOTATED | Summary: positive regulation of protein localization is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1903829 (positive regulation of protein localization), the IMP annotation with qualifier involved_in from PMID:27356871 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005829 cytosol | IDA PMID:10747907 Interaction of tau with the neural membrane cortex is regula... | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005829 (cytosol), the IDA annotation with qualifier located_in from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | IDA PMID:10747907 Interaction of tau with the neural membrane cortex is regula... | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0008017 microtubule binding | IMP PMID:10747907 Interaction of tau with the neural membrane cortex is regula... | ACCEPT | Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0008017 (microtubule binding), the IMP annotation with qualifier enables from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0015630 microtubule cytoskeleton | IDA PMID:15147841 Surface-decoration of microtubules by human tau. | ACCEPT | Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier located_in from PMID:15147841 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030673 axolemma | IDA PMID:10747907 Interaction of tau with the neural membrane cortex is regula... | ACCEPT | Summary: axolemma is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030673 (axolemma), the IDA annotation with qualifier located_in from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0042802 identical protein binding | IMP PMID:14769047 Tau paired helical filaments from Alzheimer's disease brain ... | ACCEPT | Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0042802 (identical protein binding), the IMP annotation with qualifier enables from PMID:14769047 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0042802 identical protein binding | IMP PMID:7929085 Structural studies of tau protein and Alzheimer paired helic... | ACCEPT | Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0042802 (identical protein binding), the IMP annotation with qualifier enables from PMID:7929085 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0070507 regulation of microtubule cytoskeleton organization | IMP PMID:15147841 Surface-decoration of microtubules by human tau. | ACCEPT | Summary: regulation of microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0070507 (regulation of microtubule cytoskeleton organization), the IMP annotation with qualifier involved_in from PMID:15147841 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0097418 neurofibrillary tangle | IDA PMID:2484340 Multiple isoforms of human microtubule-associated protein ta... | ACCEPT | Summary: neurofibrillary tangle is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0097418 (neurofibrillary tangle), the IDA annotation with qualifier located_in from PMID:2484340 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0097435 supramolecular fiber organization | IMP PMID:14769047 Tau paired helical filaments from Alzheimer's disease brain ... | ACCEPT | Summary: supramolecular fiber organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0097435 (supramolecular fiber organization), the IMP annotation with qualifier involved_in from PMID:14769047 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0099609 microtubule lateral binding | IMP PMID:15147841 Surface-decoration of microtubules by human tau. | ACCEPT | Summary: microtubule lateral binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0099609 (microtubule lateral binding), the IMP annotation with qualifier enables from PMID:15147841 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1990000 amyloid fibril formation | IMP PMID:7929085 Structural studies of tau protein and Alzheimer paired helic... | ACCEPT | Summary: amyloid fibril formation is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:1990000 (amyloid fibril formation), the IMP annotation with qualifier involved_in from PMID:7929085 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030425 dendrite | IDA PMID:25620700 A genome-wide gene-expression analysis and database in trans... | KEEP AS NON CORE | Summary: dendrite is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030425 (dendrite), the IDA annotation with qualifier located_in from PMID:25620700 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0044297 cell body | IDA PMID:25620700 A genome-wide gene-expression analysis and database in trans... | KEEP AS NON CORE | Summary: cell body is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0044297 (cell body), the IDA annotation with qualifier located_in from PMID:25620700 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0097418 neurofibrillary tangle | NAS PMID:25620700 A genome-wide gene-expression analysis and database in trans... | ACCEPT | Summary: neurofibrillary tangle is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0097418 (neurofibrillary tangle), the NAS annotation with qualifier located_in from PMID:25620700 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0036464 cytoplasmic ribonucleoprotein granule | IDA PMID:15121898 The composition of Staufen-containing RNA granules from huma... | KEEP AS NON CORE | Summary: cytoplasmic ribonucleoprotein granule is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0036464 (cytoplasmic ribonucleoprotein granule), the IDA annotation with qualifier located_in from PMID:15121898 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:23589030 Clathrin adaptor CALM/PICALM is associated with neurofibrill... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23589030 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:23399914 Increased expression of BIN1 mediates Alzheimer genetic risk... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23399914 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0031116 positive regulation of microtubule polymerization | IDA PMID:7706316 Microtubule-associated protein/microtubule affinity-regulati... | ACCEPT | Summary: positive regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031116 (positive regulation of microtubule polymerization), the IDA annotation with qualifier involved_in from PMID:7706316 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-201629 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-201629 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0034185 apolipoprotein binding | IPI PMID:7566652 ApoE3 binding to tau tandem repeat I is abolished by tau ser... | KEEP AS NON CORE | Summary: apolipoprotein binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0034185 (apolipoprotein binding), the IPI annotation with qualifier enables from PMID:7566652 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010506 regulation of autophagy | IGI PMID:19074461 Tau deletion exacerbates the phenotype of Niemann-Pick type ... | KEEP AS NON CORE | Summary: regulation of autophagy is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0010506 (regulation of autophagy), the IGI annotation with qualifier acts_upstream_of_or_within from PMID:19074461 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0071813 lipoprotein particle binding | IPI PMID:7972031 Isoform-specific interactions of apolipoprotein E with micro... | KEEP AS NON CORE | Summary: lipoprotein particle binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0071813 (lipoprotein particle binding), the IPI annotation with qualifier enables from PMID:7972031 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0034399 nuclear periphery | IDA PMID:19157893 Fluorescence microscopy and 3D image reconstruction of cytok... | KEEP AS NON CORE | Summary: nuclear periphery is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0034399 (nuclear periphery), the IDA annotation with qualifier located_in from PMID:19157893 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0019899 enzyme binding | IPI PMID:20133804 A role for FKBP52 in Tau protein function. | MARK AS OVER ANNOTATED | Summary: enzyme binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from PMID:20133804 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:10987820 Tau promoter confers neuronal specificity and binds Sp1 and ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:10987820 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:9689133 Presenilin 1 associates with glycogen synthase kinase-3beta ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:9689133 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005886 plasma membrane | IDA PMID:8522593 Interaction of tau with the neural plasma membrane mediated ... | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from PMID:8522593 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0008017 microtubule binding | IDA PMID:1918161 Tau protein binds to microtubules through a flexible array o... | ACCEPT | Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0008017 (microtubule binding), the IDA annotation with qualifier enables from PMID:1918161 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0017124 SH3 domain binding | IPI PMID:9763511 Tau interacts with src-family non-receptor tyrosine kinases. | KEEP AS NON CORE | Summary: SH3 domain binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0017124 (SH3 domain binding), the IPI annotation with qualifier enables from PMID:9763511 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0019899 enzyme binding | IPI PMID:12888622 Caspase cleavage of tau: linking amyloid and neurofibrillary... | MARK AS OVER ANNOTATED | Summary: enzyme binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from PMID:12888622 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0019899 enzyme binding | IPI PMID:9736630 Tau cleavage and dephosphorylation in cerebellar granule neu... | MARK AS OVER ANNOTATED | Summary: enzyme binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from PMID:9736630 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0048699 generation of neurons | NAS PMID:8522593 Interaction of tau with the neural plasma membrane mediated ... | KEEP AS NON CORE | Summary: generation of neurons is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0048699 (generation of neurons), the NAS annotation with qualifier involved_in from PMID:8522593 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0000226 microtubule cytoskeleton organization | IDA PMID:1057175 A protein factor essential for microtubule assembly. | ACCEPT | Summary: microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0000226 (microtubule cytoskeleton organization), the IDA annotation with qualifier involved_in from PMID:1057175 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030424 axon | IDA PMID:8642405 Tau is enriched on dynamic microtubules in the distal region... | ACCEPT | Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030424 (axon), the IDA annotation with qualifier located_in from PMID:8642405 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030426 growth cone | IDA PMID:8642405 Tau is enriched on dynamic microtubules in the distal region... | ACCEPT | Summary: growth cone is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0030426 (growth cone), the IDA annotation with qualifier located_in from PMID:8642405 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031113 regulation of microtubule polymerization | NAS PMID:1057175 A protein factor essential for microtubule assembly. | ACCEPT | Summary: regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031113 (regulation of microtubule polymerization), the NAS annotation with qualifier involved_in from PMID:1057175 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031116 positive regulation of microtubule polymerization | IDA PMID:1421571 Modulation of the dynamic instability of tubulin assembly by... | ACCEPT | Summary: positive regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0031116 (positive regulation of microtubule polymerization), the IDA annotation with qualifier involved_in from PMID:1421571 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0045298 tubulin complex | IDA PMID:8642405 Tau is enriched on dynamic microtubules in the distal region... | MODIFY | Summary: tubulin complex is directionally related to MAPT biology but is not the best curation target; tubulin binding better captures the specific supported function or process. Reason: For GO:0045298 (tubulin complex), the IDA annotation with qualifier part_of from PMID:8642405 supports a relationship to MAPT, but the current term is less precise than tubulin binding for the evidence and for the synthesized core/non-core role of MAPT. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: tubulin binding |
| GO:0045773 positive regulation of axon extension | IDA PMID:1389180 Suppression of MAP2 in cultured cerebellar macroneurons inhi... | ACCEPT | Summary: positive regulation of axon extension is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0045773 (positive regulation of axon extension), the IDA annotation with qualifier involved_in from PMID:1389180 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:15953362 Sequestosome 1/p62 shuttles polyubiquitinated tau for protea... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15953362 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
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Download this section (compressed HTML)Q: Which tau annotations should be treated as normal neuronal microtubule/axon biology versus pathological tauopathy gain-of-function or mislocalization?
Q: Which kinase-, phosphatase-, chaperone-, lipid-, and APOE-interaction annotations are reproducible endogenous tau functions rather than context-specific or high-throughput interactions?
Q: For Alzheimer-relevant pathway modules, should extracellular tau secretion/spread, synaptic toxicity, mitochondrial dysfunction, and glial activation be curated as MAPT core functions or as downstream disease-context consequences?
Experiment: Use endogenous MAPT isoform and phosphosite editing in human iPSC-derived neurons, followed by live imaging of microtubule dynamics, axonal transport, membrane-cortex association, and somatodendritic tau accumulation under amyloid and kinase-activation stressors.
Hypothesis: Tau phosphorylation state determines the balance between axonal microtubule stabilization, neural membrane-cortex association, and somatodendritic mislocalization.
Type: endogenous phosphosite/isoform perturbation assay
Experiment: Compare wild-type tau with aggregation-defective and microtubule-binding-defective MAPT variants in neuronal cultures, measuring tau filament formation, neurofibrillary-tangle markers, synapse localization/function, mitochondrial transport, and neuron viability.
Hypothesis: Pathological tau self-assembly is separable from normal microtubule-stabilizing activity and drives downstream synaptic and mitochondrial phenotypes.
Type: structure-function tauopathy model
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