MAPT encodes microtubule-associated protein tau, a neuronally enriched, intrinsically disordered microtubule-associated protein. Tau binds tubulin and microtubules through repeat domains, promotes microtubule assembly and stability, and contributes to axonal microtubule organization, axonal transport, neurite/axon development, and neuronal polarity. Tau also associates with neural plasma-membrane and axonal cortex components, and disease-associated phosphorylation or acetylation can alter microtubule and membrane binding. In Alzheimer disease and other tauopathies, modified tau mislocalizes and self-assembles into paired-helical-filament/neurofibrillary-tangle pathology with downstream synaptic, mitochondrial, glial, secretion, and stress-response consequences.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
|
GO:0000226
microtubule cytoskeleton organization
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0000226 (microtubule cytoskeleton organization), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0004857
enzyme inhibitor activity
|
IBA
GO_REF:0000033 |
KEEP AS NON CORE |
Summary: enzyme inhibitor activity is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0004857 (enzyme inhibitor activity), the IBA annotation with qualifier enables from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0008017
microtubule binding
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0008017 (microtubule binding), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0015630
microtubule cytoskeleton
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0015630 (microtubule cytoskeleton), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0030424
axon
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030424 (axon), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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|
GO:0060632
regulation of microtubule-based movement
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: regulation of microtubule-based movement is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0060632 (regulation of microtubule-based movement), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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|
GO:0140778
microtubule stabilizing activity
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: microtubule stabilizing activity is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0140778 (microtubule stabilizing activity), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0031175
neuron projection development
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: neuron projection development is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031175 (neuron projection development), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0005576
extracellular region
|
IEA
GO_REF:0000044 |
KEEP AS NON CORE |
Summary: extracellular region is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005576 (extracellular region), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005829
cytosol
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005829 (cytosol), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
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GO:0005856
cytoskeleton
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005856 (cytoskeleton), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0005886
plasma membrane
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0008017
microtubule binding
|
IEA
GO_REF:0000002 |
ACCEPT |
Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0008017 (microtubule binding), the IEA annotation with qualifier enables from GO_REF:0000002 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
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GO:0015631
tubulin binding
|
IEA
GO_REF:0000002 |
ACCEPT |
Summary: tubulin binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0015631 (tubulin binding), the IEA annotation with qualifier enables from GO_REF:0000002 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0030424
axon
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030424 (axon), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0030425
dendrite
|
IEA
GO_REF:0000044 |
KEEP AS NON CORE |
Summary: dendrite is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030425 (dendrite), the IEA annotation with qualifier located_in from GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:1904115
axon cytoplasm
|
IEA
GO_REF:0000108 |
ACCEPT |
Summary: axon cytoplasm is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1904115 (axon cytoplasm), the IEA annotation with qualifier located_in from GO_REF:0000108 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0005515
protein binding
|
IPI
PMID:16275660 Identification of VCP/p97, carboxyl terminus of Hsp70-intera... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16275660 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:16446437 Abeta and tau form soluble complexes that may promote self a... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16446437 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
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GO:0005515
protein binding
|
IPI
PMID:17317006 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylatio... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17317006 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:18292230 Akt and CHIP coregulate tau degradation through coordinated ... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18292230 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:19138662 Effect of phosphorylation on interaction of human tau protei... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19138662 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:19527721 Excitatory amino acid transporter 2 associates with phosphor... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19527721 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:19647741 Phosphorylation of more than one site is required for tight ... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19647741 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005515
protein binding
|
IPI
PMID:21692989 Tyrosine phosphorylation of tau regulates its interactions w... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21692989 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:24028865 Impact of the cellular prion protein on amyloid-Ξ² and 3PO-ta... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24028865 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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|
GO:0005515
protein binding
|
IPI
PMID:25156556 AlphaScreen HTS and live-cell bioluminescence resonance ener... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25156556 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:26402096 Identification of Novel Tau Interactions with Endoplasmic Re... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26402096 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:28650319 Somatostatin binds to the human amyloid Ξ² peptide and favors... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28650319 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:29764935 The disorderly conduct of Hsc70 and its interaction with the... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:29764935 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:30668577 Role of tau N-terminal motif in the secretion of human tau b... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:30668577 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:31640277 GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:31640277 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:32814053 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:33961781 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:34757590 Targeting Tau Mitigates Mitochondrial Fragmentation and Oxid... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:34757590 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
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GO:0005515
protein binding
|
IPI
PMID:7566652 ApoE3 binding to tau tandem repeat I is abolished by tau ser... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:7566652 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0042802
identical protein binding
|
IPI
PMID:16446437 Abeta and tau form soluble complexes that may promote self a... |
ACCEPT |
Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0042802 (identical protein binding), the IPI annotation with qualifier enables from PMID:16446437 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0042802
identical protein binding
|
IPI
PMID:30158706 Structures of filaments from Pick's disease reveal a novel t... |
ACCEPT |
Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0042802 (identical protein binding), the IPI annotation with qualifier enables from PMID:30158706 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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|
GO:0042802
identical protein binding
|
IPI
PMID:30894745 Novel tau filament fold in chronic traumatic encephalopathy ... |
ACCEPT |
Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0042802 (identical protein binding), the IPI annotation with qualifier enables from PMID:30894745 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0005886
plasma membrane
|
IDA
GO_REF:0000052 |
ACCEPT |
Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from GO_REF:0000052 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0005576
extracellular region
|
EXP
PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... |
KEEP AS NON CORE |
Summary: extracellular region is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005576 (extracellular region), the EXP annotation with qualifier located_in from PMID:32272059 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0004857
enzyme inhibitor activity
|
IDA
PMID:19457097 Tau--an inhibitor of deacetylase HDAC6 function. |
KEEP AS NON CORE |
Summary: enzyme inhibitor activity is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0004857 (enzyme inhibitor activity), the IDA annotation with qualifier enables from PMID:19457097 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0060632
regulation of microtubule-based movement
|
IGI
PMID:19457097 Tau--an inhibitor of deacetylase HDAC6 function. |
ACCEPT |
Summary: regulation of microtubule-based movement is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0060632 (regulation of microtubule-based movement), the IGI annotation with qualifier involved_in from PMID:19457097 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0019901
protein kinase binding
|
IPI
PMID:25556849 A novel DYRK1A (dual specificity tyrosine phosphorylation-re... |
KEEP AS NON CORE |
Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables from PMID:25556849 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9836404 |
ACCEPT |
Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-9836404 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0003779
actin binding
|
TAS
PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... |
KEEP AS NON CORE |
Summary: actin binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003779 (actin binding), the TAS annotation with qualifier enables from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:0032930
positive regulation of superoxide anion generation
|
IMP
PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... |
KEEP AS NON CORE |
Summary: positive regulation of superoxide anion generation is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0032930 (positive regulation of superoxide anion generation), the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:0090258
negative regulation of mitochondrial fission
|
IMP
PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... |
KEEP AS NON CORE |
Summary: negative regulation of mitochondrial fission is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0090258 (negative regulation of mitochondrial fission), the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0019901
protein kinase binding
|
ISS
GO_REF:0000024 |
KEEP AS NON CORE |
Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019901 (protein kinase binding), the ISS annotation with qualifier enables from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:0051087
protein-folding chaperone binding
|
IPI
PMID:25051234 Intracellular clusterin interacts with brain isoforms of the... |
KEEP AS NON CORE |
Summary: protein-folding chaperone binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0051087 (protein-folding chaperone binding), the IPI annotation with qualifier enables from PMID:25051234 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:0019899
enzyme binding
|
ISS
PMID:23362255 Isomerase Pin1 stimulates dephosphorylation of tau protein a... |
MARK AS OVER ANNOTATED |
Summary: enzyme binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019899 (enzyme binding), the ISS annotation with qualifier enables from PMID:23362255 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:27044754 FRMD4A-cytohesin signaling modulates the cellular release of... |
ACCEPT |
Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0042802 (identical protein binding), the IPI annotation with qualifier enables from PMID:27044754 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0042802
identical protein binding
|
IDA
PMID:15654759 Residual structure in the repeat domain of tau: echoes of mi... |
ACCEPT |
Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0042802 (identical protein binding), the IDA annotation with qualifier enables from PMID:15654759 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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|
GO:0097435
supramolecular fiber organization
|
IDA
PMID:15654759 Residual structure in the repeat domain of tau: echoes of mi... |
ACCEPT |
Summary: supramolecular fiber organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0097435 (supramolecular fiber organization), the IDA annotation with qualifier involved_in from PMID:15654759 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0005515
protein binding
|
IPI
PMID:22367970 Abnormal interaction between the mitochondrial fission prote... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22367970 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0019901
protein kinase binding
|
IPI
PMID:16923168 Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase c... |
KEEP AS NON CORE |
Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables from PMID:16923168 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005737
cytoplasm
|
IMP
PMID:27044754 FRMD4A-cytohesin signaling modulates the cellular release of... |
KEEP AS NON CORE |
Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005737 (cytoplasm), the IMP annotation with qualifier located_in from PMID:27044754 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0051258
protein polymerization
|
IMP
PMID:27044754 FRMD4A-cytohesin signaling modulates the cellular release of... |
ACCEPT |
Summary: protein polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0051258 (protein polymerization), the IMP annotation with qualifier involved_in from PMID:27044754 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
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GO:0005515
protein binding
|
IPI
PMID:26014385 LRRK2 Promotes Tau Accumulation, Aggregation and Release. |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26014385 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005737
cytoplasm
|
IMP
PMID:26014385 LRRK2 Promotes Tau Accumulation, Aggregation and Release. |
KEEP AS NON CORE |
Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005737 (cytoplasm), the IMP annotation with qualifier located_in from PMID:26014385 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0042802
identical protein binding
|
IMP
PMID:26014385 LRRK2 Promotes Tau Accumulation, Aggregation and Release. |
ACCEPT |
Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0042802 (identical protein binding), the IMP annotation with qualifier enables from PMID:26014385 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-NUL-9619534 |
ACCEPT |
Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-NUL-9619534 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-NUL-9619539 |
ACCEPT |
Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-NUL-9619539 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0005515
protein binding
|
IPI
PMID:24251416 Phosphorylation of human Tau protein by microtubule affinity... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24251416 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0019901
protein kinase binding
|
IPI
PMID:24251416 Phosphorylation of human Tau protein by microtubule affinity... |
KEEP AS NON CORE |
Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables from PMID:24251416 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0015630
microtubule cytoskeleton
|
NAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
ACCEPT |
Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0015630 (microtubule cytoskeleton), the NAS annotation with qualifier located_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
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GO:0015630
microtubule cytoskeleton
|
IDA
PMID:28377597 Dyrk1A overexpression leads to increase of 3R-tau expression... |
ACCEPT |
Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier located_in from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0015630
microtubule cytoskeleton
|
NAS
PMID:28386764 Roles of tau protein in health and disease. |
ACCEPT |
Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0015630 (microtubule cytoskeleton), the NAS annotation with qualifier located_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0005515
protein binding
|
IPI
PMID:23666762 Role of individual MARK isoforms in phosphorylation of tau a... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23666762 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:23666762 Role of individual MARK isoforms in phosphorylation of tau a... |
KEEP AS NON CORE |
Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:23666762 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0030425
dendrite
|
IDA
PMID:23666762 Role of individual MARK isoforms in phosphorylation of tau a... |
KEEP AS NON CORE |
Summary: dendrite is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030425 (dendrite), the IDA annotation with qualifier located_in from PMID:23666762 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0044297
cell body
|
ISS
GO_REF:0000024 |
KEEP AS NON CORE |
Summary: cell body is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0044297 (cell body), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0045121
membrane raft
|
ISS
GO_REF:0000024 |
KEEP AS NON CORE |
Summary: membrane raft is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0045121 (membrane raft), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0097386
glial cell projection
|
ISS
GO_REF:0000024 |
KEEP AS NON CORE |
Summary: glial cell projection is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0097386 (glial cell projection), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005515
protein binding
|
IPI
PMID:28755476 Regulation of the interaction between the neuronal BIN1 isof... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28755476 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005737
cytoplasm
|
ISS
GO_REF:0000024 |
KEEP AS NON CORE |
Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005737 (cytoplasm), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0008017
microtubule binding
|
TAS
PMID:26609151 Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transp... |
ACCEPT |
Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0008017 (microtubule binding), the TAS annotation with qualifier enables from PMID:26609151 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0044304
main axon
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: main axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0044304 (main axon), the ISS annotation with qualifier located_in from GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0061564
axon development
|
TAS
PMID:26609151 Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transp... |
ACCEPT |
Summary: axon development is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0061564 (axon development), the TAS annotation with qualifier involved_in from PMID:26609151 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0051879
Hsp90 protein binding
|
IPI
PMID:17517623 Roles of heat-shock protein 90 in maintaining and facilitati... |
KEEP AS NON CORE |
Summary: Hsp90 protein binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0051879 (Hsp90 protein binding), the IPI annotation with qualifier enables from PMID:17517623 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005515
protein binding
|
IPI
PMID:25051234 Intracellular clusterin interacts with brain isoforms of the... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25051234 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0046785
microtubule polymerization
|
TAS
PMID:26996940 Regulation of Microtubule Assembly by Tau and not by Pin1. |
ACCEPT |
Summary: microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0046785 (microtubule polymerization), the TAS annotation with qualifier involved_in from PMID:26996940 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0019901
protein kinase binding
|
ISS
PMID:17906291 DYRK1A-mediated hyperphosphorylation of Tau. A functional li... |
KEEP AS NON CORE |
Summary: protein kinase binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019901 (protein kinase binding), the ISS annotation with qualifier enables from PMID:17906291 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0003677
DNA binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003677 (DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0003680
minor groove of adenine-thymine-rich DNA binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: minor groove of adenine-thymine-rich DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003680 (minor groove of adenine-thymine-rich DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0003690
double-stranded DNA binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: double-stranded DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003690 (double-stranded DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0003697
single-stranded DNA binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: single-stranded DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003697 (single-stranded DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0003723
RNA binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: RNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003723 (RNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0003779
actin binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: actin binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003779 (actin binding), the TAS annotation with qualifier enables from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005576
extracellular region
|
NAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: extracellular region is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005576 (extracellular region), the NAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005634
nucleus
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: nucleus is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005634 (nucleus), the TAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005739
mitochondrion
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: mitochondrion is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005739 (mitochondrion), the TAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005886
plasma membrane
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
ACCEPT |
Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0007267
cell-cell signaling
|
NAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: cell-cell signaling is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0007267 (cell-cell signaling), the NAS annotation with qualifier involved_in from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0008017
microtubule binding
|
NAS
PMID:28386764 Roles of tau protein in health and disease. |
ACCEPT |
Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0008017 (microtubule binding), the NAS annotation with qualifier enables from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0016072
rRNA metabolic process
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: rRNA metabolic process is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0016072 (rRNA metabolic process), the TAS annotation with qualifier involved_in from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0021954
central nervous system neuron development
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: central nervous system neuron development is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0021954 (central nervous system neuron development), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0030424
axon
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
ACCEPT |
Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030424 (axon), the TAS annotation with qualifier located_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0030674
protein-macromolecule adaptor activity
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
ACCEPT |
Summary: protein-macromolecule adaptor activity is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030674 (protein-macromolecule adaptor activity), the TAS annotation with qualifier enables from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0031113
regulation of microtubule polymerization
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
ACCEPT |
Summary: regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031113 (regulation of microtubule polymerization), the TAS annotation with qualifier involved_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0033044
regulation of chromosome organization
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: regulation of chromosome organization is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0033044 (regulation of chromosome organization), the TAS annotation with qualifier involved_in from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0034063
stress granule assembly
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: stress granule assembly is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0034063 (stress granule assembly), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0034614
cellular response to reactive oxygen species
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: cellular response to reactive oxygen species is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0034614 (cellular response to reactive oxygen species), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0035091
phosphatidylinositol binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: phosphatidylinositol binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0035091 (phosphatidylinositol binding), the TAS annotation with qualifier enables from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0036477
somatodendritic compartment
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: somatodendritic compartment is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0036477 (somatodendritic compartment), the TAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0043197
dendritic spine
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: dendritic spine is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0043197 (dendritic spine), the TAS annotation with qualifier located_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0043565
sequence-specific DNA binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: sequence-specific DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0043565 (sequence-specific DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0048167
regulation of synaptic plasticity
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: regulation of synaptic plasticity is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0048167 (regulation of synaptic plasticity), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:0070507
regulation of microtubule cytoskeleton organization
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
ACCEPT |
Summary: regulation of microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0070507 (regulation of microtubule cytoskeleton organization), the TAS annotation with qualifier involved_in from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0099077
histone-dependent DNA binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
MARK AS OVER ANNOTATED |
Summary: histone-dependent DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0099077 (histone-dependent DNA binding), the TAS annotation with qualifier enables from PMID:28386764 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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|
GO:1900452
regulation of long-term synaptic depression
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: regulation of long-term synaptic depression is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1900452 (regulation of long-term synaptic depression), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:1902936
phosphatidylinositol bisphosphate binding
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: phosphatidylinositol bisphosphate binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1902936 (phosphatidylinositol bisphosphate binding), the TAS annotation with qualifier enables from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:1990090
cellular response to nerve growth factor stimulus
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: cellular response to nerve growth factor stimulus is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1990090 (cellular response to nerve growth factor stimulus), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:1990416
cellular response to brain-derived neurotrophic factor stimulus
|
TAS
PMID:28386764 Roles of tau protein in health and disease. |
KEEP AS NON CORE |
Summary: cellular response to brain-derived neurotrophic factor stimulus is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1990416 (cellular response to brain-derived neurotrophic factor stimulus), the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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|
GO:0010288
response to lead ion
|
ISS
GO_REF:0000024 |
MARK AS OVER ANNOTATED |
Summary: response to lead ion is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0010288 (response to lead ion), the ISS annotation with qualifier involved_in from GO_REF:0000024 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0050848
regulation of calcium-mediated signaling
|
IDA
PMID:18272392 Extracellular tau promotes intracellular calcium increase th... |
KEEP AS NON CORE |
Summary: regulation of calcium-mediated signaling is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0050848 (regulation of calcium-mediated signaling), the IDA annotation with qualifier involved_in from PMID:18272392 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005515
protein binding
|
IPI
PMID:3111527 Comparison of S100b protein with calmodulin: interactions wi... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:3111527 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0031113
regulation of microtubule polymerization
|
TAS
PMID:10640627 Regulation of phosphorylation of neuronal microtubule-associ... |
ACCEPT |
Summary: regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031113 (regulation of microtubule polymerization), the TAS annotation with qualifier involved_in from PMID:10640627 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0000226
microtubule cytoskeleton organization
|
NAS
PMID:28377597 Dyrk1A overexpression leads to increase of 3R-tau expression... |
ACCEPT |
Summary: microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0000226 (microtubule cytoskeleton organization), the NAS annotation with qualifier involved_in from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0008017
microtubule binding
|
IDA
PMID:28377597 Dyrk1A overexpression leads to increase of 3R-tau expression... |
ACCEPT |
Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0008017 (microtubule binding), the IDA annotation with qualifier enables from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0098930
axonal transport
|
NAS
PMID:28377597 Dyrk1A overexpression leads to increase of 3R-tau expression... |
ACCEPT |
Summary: axonal transport is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0098930 (axonal transport), the NAS annotation with qualifier involved_in from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0005874
microtubule
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: microtubule is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005874 (microtubule), the ISS annotation with qualifier colocalizes_with from GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0010629
negative regulation of gene expression
|
IMP
PMID:23164821 Clusterin regulates Ξ²-amyloid toxicity via Dickkopf-1-driven... |
MARK AS OVER ANNOTATED |
Summary: negative regulation of gene expression is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0010629 (negative regulation of gene expression), the IMP annotation with qualifier involved_in from PMID:23164821 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005515
protein binding
|
IPI
PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20655099 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0007613
memory
|
IMP
PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... |
KEEP AS NON CORE |
Summary: memory is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0007613 (memory), the IMP annotation with qualifier involved_in from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0016020
membrane
|
IMP
PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... |
KEEP AS NON CORE |
Summary: membrane is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0016020 (membrane), the IMP annotation with qualifier colocalizes_with from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0036477
somatodendritic compartment
|
IMP
PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... |
KEEP AS NON CORE |
Summary: somatodendritic compartment is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0036477 (somatodendritic compartment), the IMP annotation with qualifier located_in from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0043025
neuronal cell body
|
IMP
PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... |
KEEP AS NON CORE |
Summary: neuronal cell body is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0043025 (neuronal cell body), the IMP annotation with qualifier located_in from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0050808
synapse organization
|
IMP
PMID:17270732 Synapse loss and microglial activation precede tangles in a ... |
KEEP AS NON CORE |
Summary: synapse organization is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0050808 (synapse organization), the IMP annotation with qualifier involved_in from PMID:17270732 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:1902474
positive regulation of protein localization to synapse
|
IMP
PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ... |
KEEP AS NON CORE |
Summary: positive regulation of protein localization to synapse is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1902474 (positive regulation of protein localization to synapse), the IMP annotation with qualifier involved_in from PMID:20655099 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0003677
DNA binding
|
ISS
GO_REF:0000024 |
MARK AS OVER ANNOTATED |
Summary: DNA binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003677 (DNA binding), the ISS annotation with qualifier enables from GO_REF:0000024 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005634
nucleus
|
ISS
GO_REF:0000024 |
KEEP AS NON CORE |
Summary: nucleus is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005634 (nucleus), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0005829
cytosol
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005829 (cytosol), the ISS annotation with qualifier located_in from GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0006974
DNA damage response
|
IMP
PMID:21131359 Nuclear tau, a key player in neuronal DNA protection. |
KEEP AS NON CORE |
Summary: DNA damage response is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0006974 (DNA damage response), the IMP annotation with qualifier involved_in from PMID:21131359 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0010917
negative regulation of mitochondrial membrane potential
|
IMP
PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... |
KEEP AS NON CORE |
Summary: negative regulation of mitochondrial membrane potential is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0010917 (negative regulation of mitochondrial membrane potential), the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0090140
regulation of mitochondrial fission
|
IC
PMID:22367970 Abnormal interaction between the mitochondrial fission prote... |
KEEP AS NON CORE |
Summary: regulation of mitochondrial fission is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0090140 (regulation of mitochondrial fission), the IC annotation with qualifier involved_in from PMID:22367970 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:1900034
regulation of cellular response to heat
|
IMP
PMID:21131359 Nuclear tau, a key player in neuronal DNA protection. |
KEEP AS NON CORE |
Summary: regulation of cellular response to heat is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1900034 (regulation of cellular response to heat), the IMP annotation with qualifier involved_in from PMID:21131359 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:1903748
negative regulation of protein localization to mitochondrion
|
IMP
PMID:22920254 Tau promotes neurodegeneration via DRP1 mislocalization in v... |
KEEP AS NON CORE |
Summary: negative regulation of protein localization to mitochondrion is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1903748 (negative regulation of protein localization to mitochondrion), the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0048312
intracellular distribution of mitochondria
|
IMP
PMID:21854751 Tau accumulation causes mitochondrial distribution deficits ... |
KEEP AS NON CORE |
Summary: intracellular distribution of mitochondria is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0048312 (intracellular distribution of mitochondria), the IMP annotation with qualifier involved_in from PMID:21854751 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0001774
microglial cell activation
|
TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
KEEP AS NON CORE |
Summary: microglial cell activation is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0001774 (microglial cell activation), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0003779
actin binding
|
TAS
PMID:27306859 Tau physiology and pathomechanisms in frontotemporal lobar d... |
KEEP AS NON CORE |
Summary: actin binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0003779 (actin binding), the TAS annotation with qualifier enables from PMID:27306859 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0008017
microtubule binding
|
TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
ACCEPT |
Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0008017 (microtubule binding), the TAS annotation with qualifier enables from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0019896
axonal transport of mitochondrion
|
TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
KEEP AS NON CORE |
Summary: axonal transport of mitochondrion is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019896 (axonal transport of mitochondrion), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0030424
axon
|
NAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
ACCEPT |
Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030424 (axon), the NAS annotation with qualifier located_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0031122
cytoplasmic microtubule organization
|
TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
ACCEPT |
Summary: cytoplasmic microtubule organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031122 (cytoplasmic microtubule organization), the TAS annotation with qualifier involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0031175
neuron projection development
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TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
ACCEPT |
Summary: neuron projection development is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031175 (neuron projection development), the TAS annotation with qualifier involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0034452
dynactin binding
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TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
KEEP AS NON CORE |
Summary: dynactin binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0034452 (dynactin binding), the TAS annotation with qualifier enables from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0034605
cellular response to heat
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TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
KEEP AS NON CORE |
Summary: cellular response to heat is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0034605 (cellular response to heat), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0048143
astrocyte activation
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TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
KEEP AS NON CORE |
Summary: astrocyte activation is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0048143 (astrocyte activation), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0051721
protein phosphatase 2A binding
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TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
KEEP AS NON CORE |
Summary: protein phosphatase 2A binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0051721 (protein phosphatase 2A binding), the TAS annotation with qualifier enables from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0072386
plus-end-directed organelle transport along microtubule
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TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
KEEP AS NON CORE |
Summary: plus-end-directed organelle transport along microtubule is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0072386 (plus-end-directed organelle transport along microtubule), the TAS annotation with qualifier involved_in from PMID:26363795 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0098930
axonal transport
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TAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
ACCEPT |
Summary: axonal transport is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0098930 (axonal transport), the TAS annotation with qualifier involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:1902988
neurofibrillary tangle assembly
|
NAS
PMID:26363795 The Role of MAPT in Neurodegenerative Diseases: Genetics, Me... |
ACCEPT |
Summary: neurofibrillary tangle assembly is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1902988 (neurofibrillary tangle assembly), the NAS annotation with qualifier involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0005737
cytoplasm
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IDA
PMID:27356871 Acetylated tau destabilizes the cytoskeleton in the axon ini... |
KEEP AS NON CORE |
Summary: cytoplasm is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:27356871 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0015630
microtubule cytoskeleton
|
IDA
PMID:27356871 Acetylated tau destabilizes the cytoskeleton in the axon ini... |
ACCEPT |
Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier located_in from PMID:27356871 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0031110
regulation of microtubule polymerization or depolymerization
|
IMP
PMID:27356871 Acetylated tau destabilizes the cytoskeleton in the axon ini... |
ACCEPT |
Summary: regulation of microtubule polymerization or depolymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031110 (regulation of microtubule polymerization or depolymerization), the IMP annotation with qualifier involved_in from PMID:27356871 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:1903829
positive regulation of protein localization
|
IMP
PMID:27356871 Acetylated tau destabilizes the cytoskeleton in the axon ini... |
MARK AS OVER ANNOTATED |
Summary: positive regulation of protein localization is marked over-annotated for MAPT because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1903829 (positive regulation of protein localization), the IMP annotation with qualifier involved_in from PMID:27356871 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005829
cytosol
|
IDA
PMID:10747907 Interaction of tau with the neural membrane cortex is regula... |
ACCEPT |
Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005829 (cytosol), the IDA annotation with qualifier located_in from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0005886
plasma membrane
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IDA
PMID:10747907 Interaction of tau with the neural membrane cortex is regula... |
ACCEPT |
Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0008017
microtubule binding
|
IMP
PMID:10747907 Interaction of tau with the neural membrane cortex is regula... |
ACCEPT |
Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0008017 (microtubule binding), the IMP annotation with qualifier enables from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0015630
microtubule cytoskeleton
|
IDA
PMID:15147841 Surface-decoration of microtubules by human tau. |
ACCEPT |
Summary: microtubule cytoskeleton is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier located_in from PMID:15147841 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0030673
axolemma
|
IDA
PMID:10747907 Interaction of tau with the neural membrane cortex is regula... |
ACCEPT |
Summary: axolemma is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030673 (axolemma), the IDA annotation with qualifier located_in from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0042802
identical protein binding
|
IMP
PMID:14769047 Tau paired helical filaments from Alzheimer's disease brain ... |
ACCEPT |
Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0042802 (identical protein binding), the IMP annotation with qualifier enables from PMID:14769047 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0042802
identical protein binding
|
IMP
PMID:7929085 Structural studies of tau protein and Alzheimer paired helic... |
ACCEPT |
Summary: identical protein binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0042802 (identical protein binding), the IMP annotation with qualifier enables from PMID:7929085 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0070507
regulation of microtubule cytoskeleton organization
|
IMP
PMID:15147841 Surface-decoration of microtubules by human tau. |
ACCEPT |
Summary: regulation of microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0070507 (regulation of microtubule cytoskeleton organization), the IMP annotation with qualifier involved_in from PMID:15147841 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0097418
neurofibrillary tangle
|
IDA
PMID:2484340 Multiple isoforms of human microtubule-associated protein ta... |
ACCEPT |
Summary: neurofibrillary tangle is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0097418 (neurofibrillary tangle), the IDA annotation with qualifier located_in from PMID:2484340 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0097435
supramolecular fiber organization
|
IMP
PMID:14769047 Tau paired helical filaments from Alzheimer's disease brain ... |
ACCEPT |
Summary: supramolecular fiber organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0097435 (supramolecular fiber organization), the IMP annotation with qualifier involved_in from PMID:14769047 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0099609
microtubule lateral binding
|
IMP
PMID:15147841 Surface-decoration of microtubules by human tau. |
ACCEPT |
Summary: microtubule lateral binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0099609 (microtubule lateral binding), the IMP annotation with qualifier enables from PMID:15147841 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:1990000
amyloid fibril formation
|
IMP
PMID:7929085 Structural studies of tau protein and Alzheimer paired helic... |
ACCEPT |
Summary: amyloid fibril formation is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:1990000 (amyloid fibril formation), the IMP annotation with qualifier involved_in from PMID:7929085 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0030425
dendrite
|
IDA
PMID:25620700 A genome-wide gene-expression analysis and database in trans... |
KEEP AS NON CORE |
Summary: dendrite is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030425 (dendrite), the IDA annotation with qualifier located_in from PMID:25620700 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0044297
cell body
|
IDA
PMID:25620700 A genome-wide gene-expression analysis and database in trans... |
KEEP AS NON CORE |
Summary: cell body is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0044297 (cell body), the IDA annotation with qualifier located_in from PMID:25620700 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0097418
neurofibrillary tangle
|
NAS
PMID:25620700 A genome-wide gene-expression analysis and database in trans... |
ACCEPT |
Summary: neurofibrillary tangle is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0097418 (neurofibrillary tangle), the NAS annotation with qualifier located_in from PMID:25620700 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0036464
cytoplasmic ribonucleoprotein granule
|
IDA
PMID:15121898 The composition of Staufen-containing RNA granules from huma... |
KEEP AS NON CORE |
Summary: cytoplasmic ribonucleoprotein granule is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0036464 (cytoplasmic ribonucleoprotein granule), the IDA annotation with qualifier located_in from PMID:15121898 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0005515
protein binding
|
IPI
PMID:23589030 Clathrin adaptor CALM/PICALM is associated with neurofibrill... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23589030 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0005515
protein binding
|
IPI
PMID:23399914 Increased expression of BIN1 mediates Alzheimer genetic risk... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23399914 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
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GO:0031116
positive regulation of microtubule polymerization
|
IDA
PMID:7706316 Microtubule-associated protein/microtubule affinity-regulati... |
ACCEPT |
Summary: positive regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031116 (positive regulation of microtubule polymerization), the IDA annotation with qualifier involved_in from PMID:7706316 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0005829
cytosol
|
TAS
Reactome:R-HSA-201629 |
ACCEPT |
Summary: cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-201629 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
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GO:0034185
apolipoprotein binding
|
IPI
PMID:7566652 ApoE3 binding to tau tandem repeat I is abolished by tau ser... |
KEEP AS NON CORE |
Summary: apolipoprotein binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0034185 (apolipoprotein binding), the IPI annotation with qualifier enables from PMID:7566652 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0010506
regulation of autophagy
|
IGI
PMID:19074461 Tau deletion exacerbates the phenotype of Niemann-Pick type ... |
KEEP AS NON CORE |
Summary: regulation of autophagy is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0010506 (regulation of autophagy), the IGI annotation with qualifier acts_upstream_of_or_within from PMID:19074461 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
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GO:0071813
lipoprotein particle binding
|
IPI
PMID:7972031 Isoform-specific interactions of apolipoprotein E with micro... |
KEEP AS NON CORE |
Summary: lipoprotein particle binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0071813 (lipoprotein particle binding), the IPI annotation with qualifier enables from PMID:7972031 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0034399
nuclear periphery
|
IDA
PMID:19157893 Fluorescence microscopy and 3D image reconstruction of cytok... |
KEEP AS NON CORE |
Summary: nuclear periphery is retained as a non-core cellular-component/localization annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0034399 (nuclear periphery), the IDA annotation with qualifier located_in from PMID:19157893 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0019899
enzyme binding
|
IPI
PMID:20133804 A role for FKBP52 in Tau protein function. |
MARK AS OVER ANNOTATED |
Summary: enzyme binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from PMID:20133804 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005515
protein binding
|
IPI
PMID:10987820 Tau promoter confers neuronal specificity and binds Sp1 and ... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:10987820 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005515
protein binding
|
IPI
PMID:9689133 Presenilin 1 associates with glycogen synthase kinase-3beta ... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:9689133 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0005886
plasma membrane
|
IDA
PMID:8522593 Interaction of tau with the neural plasma membrane mediated ... |
ACCEPT |
Summary: plasma membrane is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from PMID:8522593 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0008017
microtubule binding
|
IDA
PMID:1918161 Tau protein binds to microtubules through a flexible array o... |
ACCEPT |
Summary: microtubule binding is retained as a core molecular-function annotation for MAPT; it captures activity or binding specificity within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0008017 (microtubule binding), the IDA annotation with qualifier enables from PMID:1918161 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0017124
SH3 domain binding
|
IPI
PMID:9763511 Tau interacts with src-family non-receptor tyrosine kinases. |
KEEP AS NON CORE |
Summary: SH3 domain binding is retained as a non-core molecular-function annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0017124 (SH3 domain binding), the IPI annotation with qualifier enables from PMID:9763511 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0019899
enzyme binding
|
IPI
PMID:12888622 Caspase cleavage of tau: linking amyloid and neurofibrillary... |
MARK AS OVER ANNOTATED |
Summary: enzyme binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from PMID:12888622 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0019899
enzyme binding
|
IPI
PMID:9736630 Tau cleavage and dephosphorylation in cerebellar granule neu... |
MARK AS OVER ANNOTATED |
Summary: enzyme binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from PMID:9736630 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
|
GO:0048699
generation of neurons
|
NAS
PMID:8522593 Interaction of tau with the neural plasma membrane mediated ... |
KEEP AS NON CORE |
Summary: generation of neurons is retained as a non-core biological-process annotation for MAPT; it records a supported context, interaction, localization, or pathway branch that is secondary to tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0048699 (generation of neurons), the NAS annotation with qualifier involved_in from PMID:8522593 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal MAPT function: tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
|
|
GO:0000226
microtubule cytoskeleton organization
|
IDA
PMID:1057175 A protein factor essential for microtubule assembly. |
ACCEPT |
Summary: microtubule cytoskeleton organization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0000226 (microtubule cytoskeleton organization), the IDA annotation with qualifier involved_in from PMID:1057175 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0030424
axon
|
IDA
PMID:8642405 Tau is enriched on dynamic microtubules in the distal region... |
ACCEPT |
Summary: axon is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030424 (axon), the IDA annotation with qualifier located_in from PMID:8642405 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0030426
growth cone
|
IDA
PMID:8642405 Tau is enriched on dynamic microtubules in the distal region... |
ACCEPT |
Summary: growth cone is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0030426 (growth cone), the IDA annotation with qualifier located_in from PMID:8642405 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0031113
regulation of microtubule polymerization
|
NAS
PMID:1057175 A protein factor essential for microtubule assembly. |
ACCEPT |
Summary: regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031113 (regulation of microtubule polymerization), the NAS annotation with qualifier involved_in from PMID:1057175 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0031116
positive regulation of microtubule polymerization
|
IDA
PMID:1421571 Modulation of the dynamic instability of tubulin assembly by... |
ACCEPT |
Summary: positive regulation of microtubule polymerization is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0031116 (positive regulation of microtubule polymerization), the IDA annotation with qualifier involved_in from PMID:1421571 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
|
GO:0045298
tubulin complex
|
IDA
PMID:8642405 Tau is enriched on dynamic microtubules in the distal region... |
MODIFY |
Summary: tubulin complex is directionally related to MAPT biology but is not the best curation target; tubulin binding better captures the specific supported function or process.
Reason: For GO:0045298 (tubulin complex), the IDA annotation with qualifier part_of from PMID:8642405 supports a relationship to MAPT, but the current term is less precise than tubulin binding for the evidence and for the synthesized core/non-core role of MAPT. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term.
Proposed replacements:
tubulin binding
|
|
GO:0045773
positive regulation of axon extension
|
IDA
PMID:1389180 Suppression of MAP2 in cultured cerebellar macroneurons inhi... |
ACCEPT |
Summary: positive regulation of axon extension is retained as a core biological-process annotation for MAPT; it captures process participation within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0045773 (positive regulation of axon extension), the IDA annotation with qualifier involved_in from PMID:1389180 is consistent with MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. This action keeps the term because it provides a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation annotation rather than only a downstream phenotype or generic interaction label.
|
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GO:0005515
protein binding
|
IPI
PMID:15953362 Sequestosome 1/p62 shuttles polyubiquitinated tau for protea... |
MARK AS OVER ANNOTATED |
Summary: protein binding is marked over-annotated for MAPT because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15953362 may reflect a real assay result or interaction, but this GO term does not identify the specific microtubule, tubulin-binding, localization, or tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule assembly and stability, axonal localization, and tau phosphorylation-state biology. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
|
Q: Which tau annotations should be treated as normal neuronal microtubule/axon biology versus pathological tauopathy gain-of-function or mislocalization?
Q: Which kinase-, phosphatase-, chaperone-, lipid-, and APOE-interaction annotations are reproducible endogenous tau functions rather than context-specific or high-throughput interactions?
Q: For Alzheimer-relevant pathway modules, should extracellular tau secretion/spread, synaptic toxicity, mitochondrial dysfunction, and glial activation be curated as MAPT core functions or as downstream disease-context consequences?
Experiment: Use endogenous MAPT isoform and phosphosite editing in human iPSC-derived neurons, followed by live imaging of microtubule dynamics, axonal transport, membrane-cortex association, and somatodendritic tau accumulation under amyloid and kinase-activation stressors.
Hypothesis: Tau phosphorylation state determines the balance between axonal microtubule stabilization, neural membrane-cortex association, and somatodendritic mislocalization.
Type: endogenous phosphosite/isoform perturbation assay
Experiment: Compare wild-type tau with aggregation-defective and microtubule-binding-defective MAPT variants in neuronal cultures, measuring tau filament formation, neurofibrillary-tangle markers, synapse localization/function, mitochondrial transport, and neuron viability.
Hypothesis: Pathological tau self-assembly is separable from normal microtubule-stabilizing activity and drives downstream synaptic and mitochondrial phenotypes.
Type: structure-function tauopathy model
Automated deep research was attempted with just deep-research-falcon human MAPT --fallback perplexity-lite, but the run timed out before producing a deep-research file. This review therefore uses cached GOA publications, the UniProt record, and the PANTHER family fetch.
MAPT encodes microtubule-associated protein tau. The UniProt record summarizes the core tau function as microtubule assembly/stability and neuronal polarity, and notes the microtubule/plasma-membrane linker model: "Promotes microtubule assembly and stability", "involved in the establishment and maintenance of neuronal polarity", "The C-terminus binds axonal microtubules", and "N-terminus binds neural plasma membrane components" [file:human/MAPT/MAPT-uniprot.txt "Promotes microtubule assembly and stability"; file:human/MAPT/MAPT-uniprot.txt "involved in the establishment and maintenance of neuronal polarity"; file:human/MAPT/MAPT-uniprot.txt "The C-terminus binds axonal microtubules"; file:human/MAPT/MAPT-uniprot.txt "N-terminus binds neural plasma membrane components"]. PANTHER places MAPT in PTHR11501:SF14, microtubule-associated protein tau.
Primary microtubule-binding evidence supports the central GO annotations. Santarella et al. describe tau as a neuronal microtubule-associated protein that stabilizes microtubules and promotes neurite outgrowth; their structural study reports that tau constructs "bind exclusively to the outside of microtubules" and that "even minute concentrations of tau have a strong" stabilizing effect [PMID:15147841 "Tau is a neuronal, microtubule-associated protein"; PMID:15147841 "stabilizes microtubules"; PMID:15147841 "promotes neurite outgrowth"; PMID:15147841 "bind exclusively to the outside of microtubules"; PMID:15147841 "even minute concentrations of tau have a strong"]. Phosphorylation of tau in the repeat domain can detach tau from microtubules: Drewes et al. report that phosphorylation "largely abolishes tau's binding to microtubules" and makes microtubules "dynamically unstable" [PMID:7706316 "largely abolishes tau's binding to microtubules"; PMID:7706316 "dynamically unstable"].
Tau also has a supported axonal/membrane association. The neural membrane cortex paper describes "The axonal microtubule-associated phosphoprotein tau", reports that tau membrane association "requires an intact membrane cortex", and links endogenous phosphoisoforms to "enrichment in the axonal compartment" [PMID:10747907 "The axonal microtubule-associated phosphoprotein tau"; PMID:10747907 "requires an intact membrane cortex"; PMID:10747907 "enrichment in the axonal compartment"]. This supports axon, cytosol/cytoplasm, cytoskeleton, plasma membrane/axolemma, and somatodendritic/dendrite annotations, but membrane and dendritic terms should not eclipse the microtubule/axon core.
Tau pathological self-assembly is disease-relevant and should be represented separately from physiological microtubule stabilization. Goedert et al. report that "multiple tau protein isoforms are incorporated into" the "neurofibrillary tangles of Alzheimer's disease" [PMID:2484340 "multiple tau protein isoforms are incorporated into"; PMID:2484340 "neurofibrillary tangles of Alzheimer's disease"]. A MAPT neurodegeneration review states that MAPT is "tightly implicated in keeping the function of microtubules" and "axonal transport" and that hyperphosphorylated tau participates in "neurofibrillary tangles (NFTs)" [PMID:26363795 "tightly implicated in keeping the function of microtubules"; PMID:26363795 "axonal transport"; PMID:26363795 "neurofibrillary tangles (NFTs)"]. The broader tau-function review similarly states that "Tau is well established as a microtubule-associated protein in neurons" and that pathological tau assembly is accompanied by "synaptic dysfunction and neural cell death" [PMID:28386764 "Tau is well established as a microtubule-associated protein in neurons"; PMID:28386764 "synaptic dysfunction and neural cell death"].
For curation, accept the core microtubule binding/stabilizing, microtubule organization/polymerization, axonal localization, and tau self-assembly/tangle annotations. Keep synaptic, mitochondrial, extracellular secretion, nucleic-acid/nuclear, stress-response, glial activation, and disease-model phenotypes as non-core when evidence is credible but downstream or context-specific. Mark generic protein binding and very broad or poorly informative review-derived labels as over-annotated, especially when more informative partner-specific or microtubule-specific terms are already present.
The second-pass audit confirmed the existing MAPT review and manual reference metadata. No annotation action changes were needed: MAPT remains curated around tau microtubule binding, microtubule stabilization/polymerization, axonal localization, and pathological tau self-assembly, with synaptic, mitochondrial, extracellular, nuclear/nucleic-acid, stress-response, glial, and disease-model phenotypes kept non-core or over-annotated according to the first-pass rationale.
id: P10636
gene_symbol: MAPT
product_type: PROTEIN
status: COMPLETE
taxon:
id: NCBITaxon:9606
label: Homo sapiens
description: 'MAPT encodes microtubule-associated protein tau, a neuronally enriched,
intrinsically disordered microtubule-associated protein. Tau binds tubulin and microtubules
through repeat domains, promotes microtubule assembly and stability, and contributes
to axonal microtubule organization, axonal transport, neurite/axon development,
and neuronal polarity. Tau also associates with neural plasma-membrane and axonal
cortex components, and disease-associated phosphorylation or acetylation can alter
microtubule and membrane binding. In Alzheimer disease and other tauopathies, modified
tau mislocalizes and self-assembles into paired-helical-filament/neurofibrillary-tangle
pathology with downstream synaptic, mitochondrial, glial, secretion, and stress-response
consequences.'
alternative_products:
- name: PNS-tau
id: P10636-1
- name: Fetal-tau (0N3R {ECO:0000303|PubMed:9789048})
id: P10636-2
sequence_note: VSP_003176, VSP_003177, VSP_003179,
- name: Tau-A
id: P10636-3
sequence_note: VSP_003175, VSP_003176, VSP_003177,
- name: Tau-B (1N3R {ECO:0000303|PubMed:9789048})
id: P10636-4
sequence_note: VSP_003177, VSP_003179, VSP_003180,
- name: Tau-C (Tau-3, 2N3R {ECO:0000303|PubMed:9789048})
id: P10636-5
sequence_note: VSP_003179, VSP_003180, VSP_003181
- name: Tau-D (0N4R {ECO:0000303|PubMed:9789048})
id: P10636-6
sequence_note: VSP_003176, VSP_003177, VSP_003179,
- name: Tau-E (1N4R {ECO:0000303|PubMed:9789048})
id: P10636-7
sequence_note: VSP_003177, VSP_003179, VSP_003180
- name: Tau-F (Tau-4, 2N4R {ECO:0000303|PubMed:9789048})
id: P10636-8
sequence_note: VSP_003179, VSP_003180
- name: Tau-G
id: P10636-9
sequence_note: VSP_026780
existing_annotations:
- term:
id: GO:0000226
label: microtubule cytoskeleton organization
evidence_type: IBA
original_reference_id: GO_REF:0000033
qualifier: involved_in
review:
summary: >-
microtubule cytoskeleton organization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0000226 (microtubule cytoskeleton organization), the IBA annotation with
qualifier involved_in from GO_REF:0000033 is consistent with MAPT's core role
in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0004857
label: enzyme inhibitor activity
evidence_type: IBA
original_reference_id: GO_REF:0000033
qualifier: enables
review:
summary: >-
enzyme inhibitor activity is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0004857 (enzyme inhibitor activity), the IBA annotation with qualifier
enables from GO_REF:0000033 supports retaining the annotation, but the term
describes a context-specific outcome or peripheral branch rather than the principal
MAPT function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0008017
label: microtubule binding
evidence_type: IBA
original_reference_id: GO_REF:0000033
qualifier: enables
review:
summary: >-
microtubule binding is retained as a core molecular-function annotation for
MAPT; it captures activity or binding specificity within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0008017 (microtubule binding), the IBA annotation with qualifier enables
from GO_REF:0000033 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0015630
label: microtubule cytoskeleton
evidence_type: IBA
original_reference_id: GO_REF:0000033
qualifier: is_active_in
review:
summary: >-
microtubule cytoskeleton is retained as a core cellular-component/localization
annotation for MAPT; it captures site of action or component context within
the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0015630 (microtubule cytoskeleton), the IBA annotation with qualifier
is_active_in from GO_REF:0000033 is consistent with MAPT's core role in tau
binding to tubulin and microtubules, regulation of microtubule assembly and
stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030424
label: axon
evidence_type: IBA
original_reference_id: GO_REF:0000033
qualifier: is_active_in
review:
summary: >-
axon is retained as a core cellular-component/localization annotation for MAPT;
it captures site of action or component context within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0030424 (axon), the IBA annotation with qualifier is_active_in from GO_REF:0000033
is consistent with MAPT's core role in tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. This action keeps the term because it provides
a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation
annotation rather than only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0060632
label: regulation of microtubule-based movement
evidence_type: IBA
original_reference_id: GO_REF:0000033
qualifier: involved_in
review:
summary: >-
regulation of microtubule-based movement is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0060632 (regulation of microtubule-based movement), the IBA annotation
with qualifier involved_in from GO_REF:0000033 is consistent with MAPT's core
role in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0140778
label: microtubule stabilizing activity
evidence_type: IBA
original_reference_id: GO_REF:0000033
qualifier: enables
review:
summary: >-
microtubule stabilizing activity is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0140778 (microtubule stabilizing activity), the IBA annotation with qualifier
enables from GO_REF:0000033 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0031175
label: neuron projection development
evidence_type: IBA
original_reference_id: GO_REF:0000033
qualifier: involved_in
review:
summary: >-
neuron projection development is retained as a core biological-process annotation
for MAPT; it captures process participation within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0031175 (neuron projection development), the IBA annotation with qualifier
involved_in from GO_REF:0000033 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005576
label: extracellular region
evidence_type: IEA
original_reference_id: GO_REF:0000044
qualifier: located_in
review:
summary: >-
extracellular region is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005576 (extracellular region), the IEA annotation with qualifier located_in
from GO_REF:0000044 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005829
label: cytosol
evidence_type: IEA
original_reference_id: GO_REF:0000044
qualifier: located_in
review:
summary: >-
cytosol is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005829 (cytosol), the IEA annotation with qualifier located_in from
GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005856
label: cytoskeleton
evidence_type: IEA
original_reference_id: GO_REF:0000044
qualifier: located_in
review:
summary: >-
cytoskeleton is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005856 (cytoskeleton), the IEA annotation with qualifier located_in
from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IEA
original_reference_id: GO_REF:0000044
qualifier: located_in
review:
summary: >-
plasma membrane is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in
from GO_REF:0000044 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0008017
label: microtubule binding
evidence_type: IEA
original_reference_id: GO_REF:0000002
qualifier: enables
review:
summary: >-
microtubule binding is retained as a core molecular-function annotation for
MAPT; it captures activity or binding specificity within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0008017 (microtubule binding), the IEA annotation with qualifier enables
from GO_REF:0000002 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0015631
label: tubulin binding
evidence_type: IEA
original_reference_id: GO_REF:0000002
qualifier: enables
review:
summary: >-
tubulin binding is retained as a core molecular-function annotation for MAPT;
it captures activity or binding specificity within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0015631 (tubulin binding), the IEA annotation with qualifier enables
from GO_REF:0000002 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030424
label: axon
evidence_type: IEA
original_reference_id: GO_REF:0000044
qualifier: located_in
review:
summary: >-
axon is retained as a core cellular-component/localization annotation for MAPT;
it captures site of action or component context within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0030424 (axon), the IEA annotation with qualifier located_in from GO_REF:0000044
is consistent with MAPT's core role in tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. This action keeps the term because it provides
a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation
annotation rather than only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030425
label: dendrite
evidence_type: IEA
original_reference_id: GO_REF:0000044
qualifier: located_in
review:
summary: >-
dendrite is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0030425 (dendrite), the IEA annotation with qualifier located_in from
GO_REF:0000044 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1904115
label: axon cytoplasm
evidence_type: IEA
original_reference_id: GO_REF:0000108
qualifier: located_in
review:
summary: >-
axon cytoplasm is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:1904115 (axon cytoplasm), the IEA annotation with qualifier located_in
from GO_REF:0000108 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16275660
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:16275660 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16446437
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:16446437 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17317006
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:17317006 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18292230
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:18292230 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19138662
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:19138662 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19527721
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:19527721 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19647741
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:19647741 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21692989
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:21692989 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24028865
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:24028865 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25156556
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:25156556 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:26402096
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:26402096 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:28650319
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:28650319 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:29764935
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:29764935 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:30668577
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:30668577 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:31640277
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:31640277 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:32814053
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:32814053 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:33961781
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:33961781 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:34757590
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:34757590 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:7566652
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:7566652 may reflect a real assay result or interaction, but this GO
term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:16446437
qualifier: enables
review:
summary: >-
identical protein binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0042802 (identical protein binding), the IPI annotation with qualifier
enables from PMID:16446437 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:30158706
qualifier: enables
review:
summary: >-
identical protein binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0042802 (identical protein binding), the IPI annotation with qualifier
enables from PMID:30158706 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:30894745
qualifier: enables
review:
summary: >-
identical protein binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0042802 (identical protein binding), the IPI annotation with qualifier
enables from PMID:30894745 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IDA
original_reference_id: GO_REF:0000052
qualifier: located_in
review:
summary: >-
plasma membrane is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in
from GO_REF:0000052 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005576
label: extracellular region
evidence_type: EXP
original_reference_id: PMID:32272059
qualifier: located_in
review:
summary: >-
extracellular region is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005576 (extracellular region), the EXP annotation with qualifier located_in
from PMID:32272059 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0004857
label: enzyme inhibitor activity
evidence_type: IDA
original_reference_id: PMID:19457097
qualifier: enables
review:
summary: >-
enzyme inhibitor activity is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0004857 (enzyme inhibitor activity), the IDA annotation with qualifier
enables from PMID:19457097 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0060632
label: regulation of microtubule-based movement
evidence_type: IGI
original_reference_id: PMID:19457097
qualifier: involved_in
review:
summary: >-
regulation of microtubule-based movement is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0060632 (regulation of microtubule-based movement), the IGI annotation
with qualifier involved_in from PMID:19457097 is consistent with MAPT's core
role in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0019901
label: protein kinase binding
evidence_type: IPI
original_reference_id: PMID:25556849
qualifier: enables
review:
summary: >-
protein kinase binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables
from PMID:25556849 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9836404
qualifier: located_in
review:
summary: >-
cytosol is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
Reactome:R-HSA-9836404 is consistent with MAPT's core role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0003779
label: actin binding
evidence_type: TAS
original_reference_id: PMID:22920254
qualifier: enables
review:
summary: >-
actin binding is retained as a non-core molecular-function annotation for MAPT;
it records a supported context, interaction, localization, or pathway branch
that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0003779 (actin binding), the TAS annotation with qualifier enables from
PMID:22920254 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0032930
label: positive regulation of superoxide anion generation
evidence_type: IMP
original_reference_id: PMID:22920254
qualifier: involved_in
review:
summary: >-
positive regulation of superoxide anion generation is retained as a non-core
biological-process annotation for MAPT; it records a supported context, interaction,
localization, or pathway branch that is secondary to tau microtubule binding,
microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0032930 (positive regulation of superoxide anion generation), the IMP
annotation with qualifier involved_in from PMID:22920254 supports retaining
the annotation, but the term describes a context-specific outcome or peripheral
branch rather than the principal MAPT function: tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. Keeping it as non-core prevents broad pathway
participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0090258
label: negative regulation of mitochondrial fission
evidence_type: IMP
original_reference_id: PMID:22920254
qualifier: involved_in
review:
summary: >-
negative regulation of mitochondrial fission is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0090258 (negative regulation of mitochondrial fission), the IMP annotation
with qualifier involved_in from PMID:22920254 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0019901
label: protein kinase binding
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: enables
review:
summary: >-
protein kinase binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0019901 (protein kinase binding), the ISS annotation with qualifier enables
from GO_REF:0000024 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0051087
label: protein-folding chaperone binding
evidence_type: IPI
original_reference_id: PMID:25051234
qualifier: enables
review:
summary: >-
protein-folding chaperone binding is retained as a non-core molecular-function
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0051087 (protein-folding chaperone binding), the IPI annotation with
qualifier enables from PMID:25051234 supports retaining the annotation, but
the term describes a context-specific outcome or peripheral branch rather than
the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0019899
label: enzyme binding
evidence_type: ISS
original_reference_id: PMID:23362255
qualifier: enables
review:
summary: >-
enzyme binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0019899 (enzyme binding), the ISS annotation with qualifier enables from
PMID:23362255 may reflect a real assay result or interaction, but this GO term
does not identify the specific microtubule, tubulin-binding, localization, or
tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. More informative gene-specific annotations
are present, so this is marked over-annotated rather than accepted as a core
function.
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:27044754
qualifier: enables
review:
summary: >-
identical protein binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0042802 (identical protein binding), the IPI annotation with qualifier
enables from PMID:27044754 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IDA
original_reference_id: PMID:15654759
qualifier: enables
review:
summary: >-
identical protein binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0042802 (identical protein binding), the IDA annotation with qualifier
enables from PMID:15654759 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0097435
label: supramolecular fiber organization
evidence_type: IDA
original_reference_id: PMID:15654759
qualifier: involved_in
review:
summary: >-
supramolecular fiber organization is retained as a core biological-process annotation
for MAPT; it captures process participation within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0097435 (supramolecular fiber organization), the IDA annotation with
qualifier involved_in from PMID:15654759 is consistent with MAPT's core role
in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22367970
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:22367970 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0019901
label: protein kinase binding
evidence_type: IPI
original_reference_id: PMID:16923168
qualifier: enables
review:
summary: >-
protein kinase binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables
from PMID:16923168 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IMP
original_reference_id: PMID:27044754
qualifier: located_in
review:
summary: >-
cytoplasm is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005737 (cytoplasm), the IMP annotation with qualifier located_in from
PMID:27044754 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0051258
label: protein polymerization
evidence_type: IMP
original_reference_id: PMID:27044754
qualifier: involved_in
review:
summary: >-
protein polymerization is retained as a core biological-process annotation for
MAPT; it captures process participation within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0051258 (protein polymerization), the IMP annotation with qualifier involved_in
from PMID:27044754 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:26014385
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:26014385 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IMP
original_reference_id: PMID:26014385
qualifier: located_in
review:
summary: >-
cytoplasm is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005737 (cytoplasm), the IMP annotation with qualifier located_in from
PMID:26014385 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IMP
original_reference_id: PMID:26014385
qualifier: enables
review:
summary: >-
identical protein binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0042802 (identical protein binding), the IMP annotation with qualifier
enables from PMID:26014385 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-NUL-9619534
qualifier: located_in
review:
summary: >-
cytosol is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
Reactome:R-NUL-9619534 is consistent with MAPT's core role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-NUL-9619539
qualifier: located_in
review:
summary: >-
cytosol is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
Reactome:R-NUL-9619539 is consistent with MAPT's core role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24251416
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:24251416 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0019901
label: protein kinase binding
evidence_type: IPI
original_reference_id: PMID:24251416
qualifier: enables
review:
summary: >-
protein kinase binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables
from PMID:24251416 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0015630
label: microtubule cytoskeleton
evidence_type: NAS
original_reference_id: PMID:26363795
qualifier: located_in
review:
summary: >-
microtubule cytoskeleton is retained as a core cellular-component/localization
annotation for MAPT; it captures site of action or component context within
the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0015630 (microtubule cytoskeleton), the NAS annotation with qualifier
located_in from PMID:26363795 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0015630
label: microtubule cytoskeleton
evidence_type: IDA
original_reference_id: PMID:28377597
qualifier: located_in
review:
summary: >-
microtubule cytoskeleton is retained as a core cellular-component/localization
annotation for MAPT; it captures site of action or component context within
the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier
located_in from PMID:28377597 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0015630
label: microtubule cytoskeleton
evidence_type: NAS
original_reference_id: PMID:28386764
qualifier: located_in
review:
summary: >-
microtubule cytoskeleton is retained as a core cellular-component/localization
annotation for MAPT; it captures site of action or component context within
the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0015630 (microtubule cytoskeleton), the NAS annotation with qualifier
located_in from PMID:28386764 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23666762
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:23666762 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:23666762
qualifier: located_in
review:
summary: >-
cytoplasm is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from
PMID:23666762 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030425
label: dendrite
evidence_type: IDA
original_reference_id: PMID:23666762
qualifier: located_in
review:
summary: >-
dendrite is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0030425 (dendrite), the IDA annotation with qualifier located_in from
PMID:23666762 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0044297
label: cell body
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: located_in
review:
summary: >-
cell body is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0044297 (cell body), the ISS annotation with qualifier located_in from
GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0045121
label: membrane raft
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: located_in
review:
summary: >-
membrane raft is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0045121 (membrane raft), the ISS annotation with qualifier located_in
from GO_REF:0000024 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0097386
label: glial cell projection
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: located_in
review:
summary: >-
glial cell projection is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0097386 (glial cell projection), the ISS annotation with qualifier located_in
from GO_REF:0000024 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:28755476
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:28755476 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005737
label: cytoplasm
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: located_in
review:
summary: >-
cytoplasm is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005737 (cytoplasm), the ISS annotation with qualifier located_in from
GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0008017
label: microtubule binding
evidence_type: TAS
original_reference_id: PMID:26609151
qualifier: enables
review:
summary: >-
microtubule binding is retained as a core molecular-function annotation for
MAPT; it captures activity or binding specificity within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0008017 (microtubule binding), the TAS annotation with qualifier enables
from PMID:26609151 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0044304
label: main axon
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: located_in
review:
summary: >-
main axon is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0044304 (main axon), the ISS annotation with qualifier located_in from
GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0061564
label: axon development
evidence_type: TAS
original_reference_id: PMID:26609151
qualifier: involved_in
review:
summary: >-
axon development is retained as a core biological-process annotation for MAPT;
it captures process participation within the synthesized core biology: tau microtubule
binding, microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0061564 (axon development), the TAS annotation with qualifier involved_in
from PMID:26609151 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0051879
label: Hsp90 protein binding
evidence_type: IPI
original_reference_id: PMID:17517623
qualifier: enables
review:
summary: >-
Hsp90 protein binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0051879 (Hsp90 protein binding), the IPI annotation with qualifier enables
from PMID:17517623 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25051234
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:25051234 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0046785
label: microtubule polymerization
evidence_type: TAS
original_reference_id: PMID:26996940
qualifier: involved_in
review:
summary: >-
microtubule polymerization is retained as a core biological-process annotation
for MAPT; it captures process participation within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0046785 (microtubule polymerization), the TAS annotation with qualifier
involved_in from PMID:26996940 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0019901
label: protein kinase binding
evidence_type: ISS
original_reference_id: PMID:17906291
qualifier: enables
review:
summary: >-
protein kinase binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0019901 (protein kinase binding), the ISS annotation with qualifier enables
from PMID:17906291 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0003677
label: DNA binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
DNA binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0003677 (DNA binding), the TAS annotation with qualifier enables from
PMID:28386764 may reflect a real assay result or interaction, but this GO term
does not identify the specific microtubule, tubulin-binding, localization, or
tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. More informative gene-specific annotations
are present, so this is marked over-annotated rather than accepted as a core
function.
- term:
id: GO:0003680
label: minor groove of adenine-thymine-rich DNA binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
minor groove of adenine-thymine-rich DNA binding is marked over-annotated for
MAPT because this molecular-function term is too generic, interaction-map-like,
or weakly informative relative to the gene-specific biology: tau microtubule
binding, microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0003680 (minor groove of adenine-thymine-rich DNA binding), the TAS annotation
with qualifier enables from PMID:28386764 may reflect a real assay result or
interaction, but this GO term does not identify the specific microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation that explains MAPT's role in
tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. More
informative gene-specific annotations are present, so this is marked over-annotated
rather than accepted as a core function.
- term:
id: GO:0003690
label: double-stranded DNA binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
double-stranded DNA binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0003690 (double-stranded DNA binding), the TAS annotation with qualifier
enables from PMID:28386764 may reflect a real assay result or interaction, but
this GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
- term:
id: GO:0003697
label: single-stranded DNA binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
single-stranded DNA binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0003697 (single-stranded DNA binding), the TAS annotation with qualifier
enables from PMID:28386764 may reflect a real assay result or interaction, but
this GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
- term:
id: GO:0003723
label: RNA binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
RNA binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0003723 (RNA binding), the TAS annotation with qualifier enables from
PMID:28386764 may reflect a real assay result or interaction, but this GO term
does not identify the specific microtubule, tubulin-binding, localization, or
tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. More informative gene-specific annotations
are present, so this is marked over-annotated rather than accepted as a core
function.
- term:
id: GO:0003779
label: actin binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
actin binding is retained as a non-core molecular-function annotation for MAPT;
it records a supported context, interaction, localization, or pathway branch
that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0003779 (actin binding), the TAS annotation with qualifier enables from
PMID:28386764 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005576
label: extracellular region
evidence_type: NAS
original_reference_id: PMID:28386764
qualifier: located_in
review:
summary: >-
extracellular region is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005576 (extracellular region), the NAS annotation with qualifier located_in
from PMID:28386764 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005634
label: nucleus
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: located_in
review:
summary: >-
nucleus is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005634 (nucleus), the TAS annotation with qualifier located_in from
PMID:28386764 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005739
label: mitochondrion
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: located_in
review:
summary: >-
mitochondrion is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005739 (mitochondrion), the TAS annotation with qualifier located_in
from PMID:28386764 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: located_in
review:
summary: >-
plasma membrane is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005886 (plasma membrane), the TAS annotation with qualifier located_in
from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0007267
label: cell-cell signaling
evidence_type: NAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
cell-cell signaling is marked over-annotated for MAPT because this biological-process
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0007267 (cell-cell signaling), the NAS annotation with qualifier involved_in
from PMID:28386764 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
- term:
id: GO:0008017
label: microtubule binding
evidence_type: NAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
microtubule binding is retained as a core molecular-function annotation for
MAPT; it captures activity or binding specificity within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0008017 (microtubule binding), the NAS annotation with qualifier enables
from PMID:28386764 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0016072
label: rRNA metabolic process
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
rRNA metabolic process is marked over-annotated for MAPT because this biological-process
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0016072 (rRNA metabolic process), the TAS annotation with qualifier involved_in
from PMID:28386764 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
- term:
id: GO:0021954
label: central nervous system neuron development
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
central nervous system neuron development is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0021954 (central nervous system neuron development), the TAS annotation
with qualifier involved_in from PMID:28386764 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030424
label: axon
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: located_in
review:
summary: >-
axon is retained as a core cellular-component/localization annotation for MAPT;
it captures site of action or component context within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0030424 (axon), the TAS annotation with qualifier located_in from PMID:28386764
is consistent with MAPT's core role in tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. This action keeps the term because it provides
a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation
annotation rather than only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030674
label: protein-macromolecule adaptor activity
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
protein-macromolecule adaptor activity is retained as a core molecular-function
annotation for MAPT; it captures activity or binding specificity within the
synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0030674 (protein-macromolecule adaptor activity), the TAS annotation
with qualifier enables from PMID:28386764 is consistent with MAPT's core role
in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0031113
label: regulation of microtubule polymerization
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
regulation of microtubule polymerization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0031113 (regulation of microtubule polymerization), the TAS annotation
with qualifier involved_in from PMID:28386764 is consistent with MAPT's core
role in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0033044
label: regulation of chromosome organization
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
regulation of chromosome organization is marked over-annotated for MAPT because
this biological-process term is too generic, interaction-map-like, or weakly
informative relative to the gene-specific biology: tau microtubule binding,
microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0033044 (regulation of chromosome organization), the TAS annotation with
qualifier involved_in from PMID:28386764 may reflect a real assay result or
interaction, but this GO term does not identify the specific microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation that explains MAPT's role in
tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. More
informative gene-specific annotations are present, so this is marked over-annotated
rather than accepted as a core function.
- term:
id: GO:0034063
label: stress granule assembly
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
stress granule assembly is retained as a non-core biological-process annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0034063 (stress granule assembly), the TAS annotation with qualifier
involved_in from PMID:28386764 supports retaining the annotation, but the term
describes a context-specific outcome or peripheral branch rather than the principal
MAPT function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0034614
label: cellular response to reactive oxygen species
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
cellular response to reactive oxygen species is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0034614 (cellular response to reactive oxygen species), the TAS annotation
with qualifier involved_in from PMID:28386764 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0035091
label: phosphatidylinositol binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
phosphatidylinositol binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0035091 (phosphatidylinositol binding), the TAS annotation with qualifier
enables from PMID:28386764 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0036477
label: somatodendritic compartment
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: located_in
review:
summary: >-
somatodendritic compartment is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0036477 (somatodendritic compartment), the TAS annotation with qualifier
located_in from PMID:28386764 supports retaining the annotation, but the term
describes a context-specific outcome or peripheral branch rather than the principal
MAPT function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0043197
label: dendritic spine
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: located_in
review:
summary: >-
dendritic spine is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0043197 (dendritic spine), the TAS annotation with qualifier located_in
from PMID:28386764 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0043565
label: sequence-specific DNA binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
sequence-specific DNA binding is marked over-annotated for MAPT because this
molecular-function term is too generic, interaction-map-like, or weakly informative
relative to the gene-specific biology: tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0043565 (sequence-specific DNA binding), the TAS annotation with qualifier
enables from PMID:28386764 may reflect a real assay result or interaction, but
this GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
- term:
id: GO:0048167
label: regulation of synaptic plasticity
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
regulation of synaptic plasticity is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0048167 (regulation of synaptic plasticity), the TAS annotation with
qualifier involved_in from PMID:28386764 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0070507
label: regulation of microtubule cytoskeleton organization
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
regulation of microtubule cytoskeleton organization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0070507 (regulation of microtubule cytoskeleton organization), the TAS
annotation with qualifier involved_in from PMID:28386764 is consistent with
MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
This action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0099077
label: histone-dependent DNA binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
histone-dependent DNA binding is marked over-annotated for MAPT because this
molecular-function term is too generic, interaction-map-like, or weakly informative
relative to the gene-specific biology: tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0099077 (histone-dependent DNA binding), the TAS annotation with qualifier
enables from PMID:28386764 may reflect a real assay result or interaction, but
this GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
- term:
id: GO:1900452
label: regulation of long-term synaptic depression
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
regulation of long-term synaptic depression is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:1900452 (regulation of long-term synaptic depression), the TAS annotation
with qualifier involved_in from PMID:28386764 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1902936
label: phosphatidylinositol bisphosphate binding
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: enables
review:
summary: >-
phosphatidylinositol bisphosphate binding is retained as a non-core molecular-function
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:1902936 (phosphatidylinositol bisphosphate binding), the TAS annotation
with qualifier enables from PMID:28386764 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1990090
label: cellular response to nerve growth factor stimulus
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
cellular response to nerve growth factor stimulus is retained as a non-core
biological-process annotation for MAPT; it records a supported context, interaction,
localization, or pathway branch that is secondary to tau microtubule binding,
microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:1990090 (cellular response to nerve growth factor stimulus), the TAS
annotation with qualifier involved_in from PMID:28386764 supports retaining
the annotation, but the term describes a context-specific outcome or peripheral
branch rather than the principal MAPT function: tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. Keeping it as non-core prevents broad pathway
participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1990416
label: cellular response to brain-derived neurotrophic factor stimulus
evidence_type: TAS
original_reference_id: PMID:28386764
qualifier: involved_in
review:
summary: >-
cellular response to brain-derived neurotrophic factor stimulus is retained
as a non-core biological-process annotation for MAPT; it records a supported
context, interaction, localization, or pathway branch that is secondary to tau
microtubule binding, microtubule assembly/stability, axonal and neuronal projection
localization, and phosphorylation-dependent regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:1990416 (cellular response to brain-derived neurotrophic factor stimulus),
the TAS annotation with qualifier involved_in from PMID:28386764 supports retaining
the annotation, but the term describes a context-specific outcome or peripheral
branch rather than the principal MAPT function: tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. Keeping it as non-core prevents broad pathway
participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0010288
label: response to lead ion
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: involved_in
review:
summary: >-
response to lead ion is marked over-annotated for MAPT because this biological-process
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0010288 (response to lead ion), the ISS annotation with qualifier involved_in
from GO_REF:0000024 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
- term:
id: GO:0050848
label: regulation of calcium-mediated signaling
evidence_type: IDA
original_reference_id: PMID:18272392
qualifier: involved_in
review:
summary: >-
regulation of calcium-mediated signaling is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0050848 (regulation of calcium-mediated signaling), the IDA annotation
with qualifier involved_in from PMID:18272392 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:3111527
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:3111527 may reflect a real assay result or interaction, but this GO
term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0031113
label: regulation of microtubule polymerization
evidence_type: TAS
original_reference_id: PMID:10640627
qualifier: involved_in
review:
summary: >-
regulation of microtubule polymerization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0031113 (regulation of microtubule polymerization), the TAS annotation
with qualifier involved_in from PMID:10640627 is consistent with MAPT's core
role in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0000226
label: microtubule cytoskeleton organization
evidence_type: NAS
original_reference_id: PMID:28377597
qualifier: involved_in
review:
summary: >-
microtubule cytoskeleton organization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0000226 (microtubule cytoskeleton organization), the NAS annotation with
qualifier involved_in from PMID:28377597 is consistent with MAPT's core role
in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0008017
label: microtubule binding
evidence_type: IDA
original_reference_id: PMID:28377597
qualifier: enables
review:
summary: >-
microtubule binding is retained as a core molecular-function annotation for
MAPT; it captures activity or binding specificity within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0008017 (microtubule binding), the IDA annotation with qualifier enables
from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0098930
label: axonal transport
evidence_type: NAS
original_reference_id: PMID:28377597
qualifier: involved_in
review:
summary: >-
axonal transport is retained as a core biological-process annotation for MAPT;
it captures process participation within the synthesized core biology: tau microtubule
binding, microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0098930 (axonal transport), the NAS annotation with qualifier involved_in
from PMID:28377597 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005874
label: microtubule
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: colocalizes_with
review:
summary: >-
microtubule is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005874 (microtubule), the ISS annotation with qualifier colocalizes_with
from GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0010629
label: negative regulation of gene expression
evidence_type: IMP
original_reference_id: PMID:23164821
qualifier: involved_in
review:
summary: >-
negative regulation of gene expression is marked over-annotated for MAPT because
this biological-process term is too generic, interaction-map-like, or weakly
informative relative to the gene-specific biology: tau microtubule binding,
microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0010629 (negative regulation of gene expression), the IMP annotation
with qualifier involved_in from PMID:23164821 may reflect a real assay result
or interaction, but this GO term does not identify the specific microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation that explains
MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
More informative gene-specific annotations are present, so this is marked over-annotated
rather than accepted as a core function.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20655099
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:20655099 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0007613
label: memory
evidence_type: IMP
original_reference_id: PMID:20655099
qualifier: involved_in
review:
summary: >-
memory is retained as a non-core biological-process annotation for MAPT; it
records a supported context, interaction, localization, or pathway branch that
is secondary to tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0007613 (memory), the IMP annotation with qualifier involved_in from
PMID:20655099 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0016020
label: membrane
evidence_type: IMP
original_reference_id: PMID:20655099
qualifier: colocalizes_with
review:
summary: >-
membrane is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0016020 (membrane), the IMP annotation with qualifier colocalizes_with
from PMID:20655099 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0036477
label: somatodendritic compartment
evidence_type: IMP
original_reference_id: PMID:20655099
qualifier: located_in
review:
summary: >-
somatodendritic compartment is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0036477 (somatodendritic compartment), the IMP annotation with qualifier
located_in from PMID:20655099 supports retaining the annotation, but the term
describes a context-specific outcome or peripheral branch rather than the principal
MAPT function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0043025
label: neuronal cell body
evidence_type: IMP
original_reference_id: PMID:20655099
qualifier: located_in
review:
summary: >-
neuronal cell body is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0043025 (neuronal cell body), the IMP annotation with qualifier located_in
from PMID:20655099 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0050808
label: synapse organization
evidence_type: IMP
original_reference_id: PMID:17270732
qualifier: involved_in
review:
summary: >-
synapse organization is retained as a non-core biological-process annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0050808 (synapse organization), the IMP annotation with qualifier involved_in
from PMID:17270732 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1902474
label: positive regulation of protein localization to synapse
evidence_type: IMP
original_reference_id: PMID:20655099
qualifier: involved_in
review:
summary: >-
positive regulation of protein localization to synapse is retained as a non-core
biological-process annotation for MAPT; it records a supported context, interaction,
localization, or pathway branch that is secondary to tau microtubule binding,
microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:1902474 (positive regulation of protein localization to synapse), the
IMP annotation with qualifier involved_in from PMID:20655099 supports retaining
the annotation, but the term describes a context-specific outcome or peripheral
branch rather than the principal MAPT function: tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. Keeping it as non-core prevents broad pathway
participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0003677
label: DNA binding
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: enables
review:
summary: >-
DNA binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0003677 (DNA binding), the ISS annotation with qualifier enables from
GO_REF:0000024 may reflect a real assay result or interaction, but this GO term
does not identify the specific microtubule, tubulin-binding, localization, or
tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. More informative gene-specific annotations
are present, so this is marked over-annotated rather than accepted as a core
function.
- term:
id: GO:0005634
label: nucleus
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: located_in
review:
summary: >-
nucleus is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005634 (nucleus), the ISS annotation with qualifier located_in from
GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005829
label: cytosol
evidence_type: ISS
original_reference_id: GO_REF:0000024
qualifier: located_in
review:
summary: >-
cytosol is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005829 (cytosol), the ISS annotation with qualifier located_in from
GO_REF:0000024 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0006974
label: DNA damage response
evidence_type: IMP
original_reference_id: PMID:21131359
qualifier: involved_in
review:
summary: >-
DNA damage response is retained as a non-core biological-process annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0006974 (DNA damage response), the IMP annotation with qualifier involved_in
from PMID:21131359 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0010917
label: negative regulation of mitochondrial membrane potential
evidence_type: IMP
original_reference_id: PMID:22920254
qualifier: involved_in
review:
summary: >-
negative regulation of mitochondrial membrane potential is retained as a non-core
biological-process annotation for MAPT; it records a supported context, interaction,
localization, or pathway branch that is secondary to tau microtubule binding,
microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0010917 (negative regulation of mitochondrial membrane potential), the
IMP annotation with qualifier involved_in from PMID:22920254 supports retaining
the annotation, but the term describes a context-specific outcome or peripheral
branch rather than the principal MAPT function: tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. Keeping it as non-core prevents broad pathway
participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0090140
label: regulation of mitochondrial fission
evidence_type: IC
original_reference_id: PMID:22367970
qualifier: involved_in
review:
summary: >-
regulation of mitochondrial fission is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0090140 (regulation of mitochondrial fission), the IC annotation with
qualifier involved_in from PMID:22367970 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1900034
label: regulation of cellular response to heat
evidence_type: IMP
original_reference_id: PMID:21131359
qualifier: involved_in
review:
summary: >-
regulation of cellular response to heat is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:1900034 (regulation of cellular response to heat), the IMP annotation
with qualifier involved_in from PMID:21131359 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1903748
label: negative regulation of protein localization to mitochondrion
evidence_type: IMP
original_reference_id: PMID:22920254
qualifier: involved_in
review:
summary: >-
negative regulation of protein localization to mitochondrion is retained as
a non-core biological-process annotation for MAPT; it records a supported context,
interaction, localization, or pathway branch that is secondary to tau microtubule
binding, microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:1903748 (negative regulation of protein localization to mitochondrion),
the IMP annotation with qualifier involved_in from PMID:22920254 supports retaining
the annotation, but the term describes a context-specific outcome or peripheral
branch rather than the principal MAPT function: tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. Keeping it as non-core prevents broad pathway
participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0048312
label: intracellular distribution of mitochondria
evidence_type: IMP
original_reference_id: PMID:21854751
qualifier: involved_in
review:
summary: >-
intracellular distribution of mitochondria is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0048312 (intracellular distribution of mitochondria), the IMP annotation
with qualifier involved_in from PMID:21854751 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0001774
label: microglial cell activation
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
microglial cell activation is retained as a non-core biological-process annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0001774 (microglial cell activation), the TAS annotation with qualifier
involved_in from PMID:26363795 supports retaining the annotation, but the term
describes a context-specific outcome or peripheral branch rather than the principal
MAPT function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0003779
label: actin binding
evidence_type: TAS
original_reference_id: PMID:27306859
qualifier: enables
review:
summary: >-
actin binding is retained as a non-core molecular-function annotation for MAPT;
it records a supported context, interaction, localization, or pathway branch
that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0003779 (actin binding), the TAS annotation with qualifier enables from
PMID:27306859 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0008017
label: microtubule binding
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: enables
review:
summary: >-
microtubule binding is retained as a core molecular-function annotation for
MAPT; it captures activity or binding specificity within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0008017 (microtubule binding), the TAS annotation with qualifier enables
from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0019896
label: axonal transport of mitochondrion
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
axonal transport of mitochondrion is retained as a non-core biological-process
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0019896 (axonal transport of mitochondrion), the TAS annotation with
qualifier involved_in from PMID:26363795 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030424
label: axon
evidence_type: NAS
original_reference_id: PMID:26363795
qualifier: located_in
review:
summary: >-
axon is retained as a core cellular-component/localization annotation for MAPT;
it captures site of action or component context within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0030424 (axon), the NAS annotation with qualifier located_in from PMID:26363795
is consistent with MAPT's core role in tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. This action keeps the term because it provides
a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation
annotation rather than only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0031122
label: cytoplasmic microtubule organization
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
cytoplasmic microtubule organization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0031122 (cytoplasmic microtubule organization), the TAS annotation with
qualifier involved_in from PMID:26363795 is consistent with MAPT's core role
in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0031175
label: neuron projection development
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
neuron projection development is retained as a core biological-process annotation
for MAPT; it captures process participation within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0031175 (neuron projection development), the TAS annotation with qualifier
involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0034452
label: dynactin binding
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: enables
review:
summary: >-
dynactin binding is retained as a non-core molecular-function annotation for
MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0034452 (dynactin binding), the TAS annotation with qualifier enables
from PMID:26363795 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0034605
label: cellular response to heat
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
cellular response to heat is retained as a non-core biological-process annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0034605 (cellular response to heat), the TAS annotation with qualifier
involved_in from PMID:26363795 supports retaining the annotation, but the term
describes a context-specific outcome or peripheral branch rather than the principal
MAPT function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0048143
label: astrocyte activation
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
astrocyte activation is retained as a non-core biological-process annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0048143 (astrocyte activation), the TAS annotation with qualifier involved_in
from PMID:26363795 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0051721
label: protein phosphatase 2A binding
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: enables
review:
summary: >-
protein phosphatase 2A binding is retained as a non-core molecular-function
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0051721 (protein phosphatase 2A binding), the TAS annotation with qualifier
enables from PMID:26363795 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0072386
label: plus-end-directed organelle transport along microtubule
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
plus-end-directed organelle transport along microtubule is retained as a non-core
biological-process annotation for MAPT; it records a supported context, interaction,
localization, or pathway branch that is secondary to tau microtubule binding,
microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0072386 (plus-end-directed organelle transport along microtubule), the
TAS annotation with qualifier involved_in from PMID:26363795 supports retaining
the annotation, but the term describes a context-specific outcome or peripheral
branch rather than the principal MAPT function: tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. Keeping it as non-core prevents broad pathway
participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0098930
label: axonal transport
evidence_type: TAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
axonal transport is retained as a core biological-process annotation for MAPT;
it captures process participation within the synthesized core biology: tau microtubule
binding, microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0098930 (axonal transport), the TAS annotation with qualifier involved_in
from PMID:26363795 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1902988
label: neurofibrillary tangle assembly
evidence_type: NAS
original_reference_id: PMID:26363795
qualifier: involved_in
review:
summary: >-
neurofibrillary tangle assembly is retained as a core biological-process annotation
for MAPT; it captures process participation within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:1902988 (neurofibrillary tangle assembly), the NAS annotation with qualifier
involved_in from PMID:26363795 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:27356871
qualifier: located_in
review:
summary: >-
cytoplasm is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from
PMID:27356871 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0015630
label: microtubule cytoskeleton
evidence_type: IDA
original_reference_id: PMID:27356871
qualifier: located_in
review:
summary: >-
microtubule cytoskeleton is retained as a core cellular-component/localization
annotation for MAPT; it captures site of action or component context within
the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier
located_in from PMID:27356871 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0031110
label: regulation of microtubule polymerization or depolymerization
evidence_type: IMP
original_reference_id: PMID:27356871
qualifier: involved_in
review:
summary: >-
regulation of microtubule polymerization or depolymerization is retained as
a core biological-process annotation for MAPT; it captures process participation
within the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0031110 (regulation of microtubule polymerization or depolymerization),
the IMP annotation with qualifier involved_in from PMID:27356871 is consistent
with MAPT's core role in tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. This action keeps the term because it provides a specific, evidence-backed
microtubule, tubulin-binding, localization, or tau-phosphorylation annotation
rather than only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1903829
label: positive regulation of protein localization
evidence_type: IMP
original_reference_id: PMID:27356871
qualifier: involved_in
review:
summary: >-
positive regulation of protein localization is marked over-annotated for MAPT
because this biological-process term is too generic, interaction-map-like, or
weakly informative relative to the gene-specific biology: tau microtubule binding,
microtubule assembly/stability, axonal and neuronal projection localization,
and phosphorylation-dependent regulation of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:1903829 (positive regulation of protein localization), the IMP annotation
with qualifier involved_in from PMID:27356871 may reflect a real assay result
or interaction, but this GO term does not identify the specific microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation that explains
MAPT's role in tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
More informative gene-specific annotations are present, so this is marked over-annotated
rather than accepted as a core function.
- term:
id: GO:0005829
label: cytosol
evidence_type: IDA
original_reference_id: PMID:10747907
qualifier: located_in
review:
summary: >-
cytosol is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005829 (cytosol), the IDA annotation with qualifier located_in from
PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IDA
original_reference_id: PMID:10747907
qualifier: located_in
review:
summary: >-
plasma membrane is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in
from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0008017
label: microtubule binding
evidence_type: IMP
original_reference_id: PMID:10747907
qualifier: enables
review:
summary: >-
microtubule binding is retained as a core molecular-function annotation for
MAPT; it captures activity or binding specificity within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0008017 (microtubule binding), the IMP annotation with qualifier enables
from PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0015630
label: microtubule cytoskeleton
evidence_type: IDA
original_reference_id: PMID:15147841
qualifier: located_in
review:
summary: >-
microtubule cytoskeleton is retained as a core cellular-component/localization
annotation for MAPT; it captures site of action or component context within
the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0015630 (microtubule cytoskeleton), the IDA annotation with qualifier
located_in from PMID:15147841 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030673
label: axolemma
evidence_type: IDA
original_reference_id: PMID:10747907
qualifier: located_in
review:
summary: >-
axolemma is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0030673 (axolemma), the IDA annotation with qualifier located_in from
PMID:10747907 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IMP
original_reference_id: PMID:14769047
qualifier: enables
review:
summary: >-
identical protein binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0042802 (identical protein binding), the IMP annotation with qualifier
enables from PMID:14769047 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IMP
original_reference_id: PMID:7929085
qualifier: enables
review:
summary: >-
identical protein binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0042802 (identical protein binding), the IMP annotation with qualifier
enables from PMID:7929085 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0070507
label: regulation of microtubule cytoskeleton organization
evidence_type: IMP
original_reference_id: PMID:15147841
qualifier: involved_in
review:
summary: >-
regulation of microtubule cytoskeleton organization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0070507 (regulation of microtubule cytoskeleton organization), the IMP
annotation with qualifier involved_in from PMID:15147841 is consistent with
MAPT's core role in tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
This action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0097418
label: neurofibrillary tangle
evidence_type: IDA
original_reference_id: PMID:2484340
qualifier: located_in
review:
summary: >-
neurofibrillary tangle is retained as a core cellular-component/localization
annotation for MAPT; it captures site of action or component context within
the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0097418 (neurofibrillary tangle), the IDA annotation with qualifier located_in
from PMID:2484340 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0097435
label: supramolecular fiber organization
evidence_type: IMP
original_reference_id: PMID:14769047
qualifier: involved_in
review:
summary: >-
supramolecular fiber organization is retained as a core biological-process annotation
for MAPT; it captures process participation within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:0097435 (supramolecular fiber organization), the IMP annotation with
qualifier involved_in from PMID:14769047 is consistent with MAPT's core role
in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0099609
label: microtubule lateral binding
evidence_type: IMP
original_reference_id: PMID:15147841
qualifier: enables
review:
summary: >-
microtubule lateral binding is retained as a core molecular-function annotation
for MAPT; it captures activity or binding specificity within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0099609 (microtubule lateral binding), the IMP annotation with qualifier
enables from PMID:15147841 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:1990000
label: amyloid fibril formation
evidence_type: IMP
original_reference_id: PMID:7929085
qualifier: involved_in
review:
summary: >-
amyloid fibril formation is retained as a core biological-process annotation
for MAPT; it captures process participation within the synthesized core biology:
tau microtubule binding, microtubule assembly/stability, axonal and neuronal
projection localization, and phosphorylation-dependent regulation of tau behavior.
action: ACCEPT
reason: >-
For GO:1990000 (amyloid fibril formation), the IMP annotation with qualifier
involved_in from PMID:7929085 is consistent with MAPT's core role in tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030425
label: dendrite
evidence_type: IDA
original_reference_id: PMID:25620700
qualifier: located_in
review:
summary: >-
dendrite is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0030425 (dendrite), the IDA annotation with qualifier located_in from
PMID:25620700 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0044297
label: cell body
evidence_type: IDA
original_reference_id: PMID:25620700
qualifier: located_in
review:
summary: >-
cell body is retained as a non-core cellular-component/localization annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0044297 (cell body), the IDA annotation with qualifier located_in from
PMID:25620700 supports retaining the annotation, but the term describes a context-specific
outcome or peripheral branch rather than the principal MAPT function: tau binding
to tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. Keeping it as non-core
prevents broad pathway participation from being promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0097418
label: neurofibrillary tangle
evidence_type: NAS
original_reference_id: PMID:25620700
qualifier: located_in
review:
summary: >-
neurofibrillary tangle is retained as a core cellular-component/localization
annotation for MAPT; it captures site of action or component context within
the synthesized core biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0097418 (neurofibrillary tangle), the NAS annotation with qualifier located_in
from PMID:25620700 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0036464
label: cytoplasmic ribonucleoprotein granule
evidence_type: IDA
original_reference_id: PMID:15121898
qualifier: located_in
review:
summary: >-
cytoplasmic ribonucleoprotein granule is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0036464 (cytoplasmic ribonucleoprotein granule), the IDA annotation with
qualifier located_in from PMID:15121898 supports retaining the annotation, but
the term describes a context-specific outcome or peripheral branch rather than
the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23589030
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:23589030 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23399914
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:23399914 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0031116
label: positive regulation of microtubule polymerization
evidence_type: IDA
original_reference_id: PMID:7706316
qualifier: involved_in
review:
summary: >-
positive regulation of microtubule polymerization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0031116 (positive regulation of microtubule polymerization), the IDA
annotation with qualifier involved_in from PMID:7706316 is consistent with MAPT's
core role in tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
This action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-201629
qualifier: located_in
review:
summary: >-
cytosol is retained as a core cellular-component/localization annotation for
MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
Reactome:R-HSA-201629 is consistent with MAPT's core role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. This action keeps
the term because it provides a specific, evidence-backed microtubule, tubulin-binding,
localization, or tau-phosphorylation annotation rather than only a downstream
phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0034185
label: apolipoprotein binding
evidence_type: IPI
original_reference_id: PMID:7566652
qualifier: enables
review:
summary: >-
apolipoprotein binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0034185 (apolipoprotein binding), the IPI annotation with qualifier enables
from PMID:7566652 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0010506
label: regulation of autophagy
evidence_type: IGI
original_reference_id: PMID:19074461
qualifier: acts_upstream_of_or_within
review:
summary: >-
regulation of autophagy is retained as a non-core biological-process annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0010506 (regulation of autophagy), the IGI annotation with qualifier
acts_upstream_of_or_within from PMID:19074461 supports retaining the annotation,
but the term describes a context-specific outcome or peripheral branch rather
than the principal MAPT function: tau binding to tubulin and microtubules, regulation
of microtubule assembly and stability, axonal localization, and tau phosphorylation-state
biology. Keeping it as non-core prevents broad pathway participation from being
promoted to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0071813
label: lipoprotein particle binding
evidence_type: IPI
original_reference_id: PMID:7972031
qualifier: enables
review:
summary: >-
lipoprotein particle binding is retained as a non-core molecular-function annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0071813 (lipoprotein particle binding), the IPI annotation with qualifier
enables from PMID:7972031 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0034399
label: nuclear periphery
evidence_type: IDA
original_reference_id: PMID:19157893
qualifier: located_in
review:
summary: >-
nuclear periphery is retained as a non-core cellular-component/localization
annotation for MAPT; it records a supported context, interaction, localization,
or pathway branch that is secondary to tau microtubule binding, microtubule
assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent
regulation of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0034399 (nuclear periphery), the IDA annotation with qualifier located_in
from PMID:19157893 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0019899
label: enzyme binding
evidence_type: IPI
original_reference_id: PMID:20133804
qualifier: enables
review:
summary: >-
enzyme binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from
PMID:20133804 may reflect a real assay result or interaction, but this GO term
does not identify the specific microtubule, tubulin-binding, localization, or
tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. More informative gene-specific annotations
are present, so this is marked over-annotated rather than accepted as a core
function.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10987820
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:10987820 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9689133
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:9689133 may reflect a real assay result or interaction, but this GO
term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IDA
original_reference_id: PMID:8522593
qualifier: located_in
review:
summary: >-
plasma membrane is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in
from PMID:8522593 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0008017
label: microtubule binding
evidence_type: IDA
original_reference_id: PMID:1918161
qualifier: enables
review:
summary: >-
microtubule binding is retained as a core molecular-function annotation for
MAPT; it captures activity or binding specificity within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0008017 (microtubule binding), the IDA annotation with qualifier enables
from PMID:1918161 is consistent with MAPT's core role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0017124
label: SH3 domain binding
evidence_type: IPI
original_reference_id: PMID:9763511
qualifier: enables
review:
summary: >-
SH3 domain binding is retained as a non-core molecular-function annotation for
MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0017124 (SH3 domain binding), the IPI annotation with qualifier enables
from PMID:9763511 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0019899
label: enzyme binding
evidence_type: IPI
original_reference_id: PMID:12888622
qualifier: enables
review:
summary: >-
enzyme binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from
PMID:12888622 may reflect a real assay result or interaction, but this GO term
does not identify the specific microtubule, tubulin-binding, localization, or
tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. More informative gene-specific annotations
are present, so this is marked over-annotated rather than accepted as a core
function.
- term:
id: GO:0019899
label: enzyme binding
evidence_type: IPI
original_reference_id: PMID:9736630
qualifier: enables
review:
summary: >-
enzyme binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0019899 (enzyme binding), the IPI annotation with qualifier enables from
PMID:9736630 may reflect a real assay result or interaction, but this GO term
does not identify the specific microtubule, tubulin-binding, localization, or
tau-phosphorylation annotation that explains MAPT's role in tau binding to tubulin
and microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. More informative gene-specific annotations
are present, so this is marked over-annotated rather than accepted as a core
function.
- term:
id: GO:0048699
label: generation of neurons
evidence_type: NAS
original_reference_id: PMID:8522593
qualifier: involved_in
review:
summary: >-
generation of neurons is retained as a non-core biological-process annotation
for MAPT; it records a supported context, interaction, localization, or pathway
branch that is secondary to tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: KEEP_AS_NON_CORE
reason: >-
For GO:0048699 (generation of neurons), the NAS annotation with qualifier involved_in
from PMID:8522593 supports retaining the annotation, but the term describes
a context-specific outcome or peripheral branch rather than the principal MAPT
function: tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
Keeping it as non-core prevents broad pathway participation from being promoted
to core function.
additional_reference_ids:
- PMID:28386764
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0000226
label: microtubule cytoskeleton organization
evidence_type: IDA
original_reference_id: PMID:1057175
qualifier: involved_in
review:
summary: >-
microtubule cytoskeleton organization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0000226 (microtubule cytoskeleton organization), the IDA annotation with
qualifier involved_in from PMID:1057175 is consistent with MAPT's core role
in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030424
label: axon
evidence_type: IDA
original_reference_id: PMID:8642405
qualifier: located_in
review:
summary: >-
axon is retained as a core cellular-component/localization annotation for MAPT;
it captures site of action or component context within the synthesized core
biology: tau microtubule binding, microtubule assembly/stability, axonal and
neuronal projection localization, and phosphorylation-dependent regulation of
tau behavior.
action: ACCEPT
reason: >-
For GO:0030424 (axon), the IDA annotation with qualifier located_in from PMID:8642405
is consistent with MAPT's core role in tau binding to tubulin and microtubules,
regulation of microtubule assembly and stability, axonal localization, and tau
phosphorylation-state biology. This action keeps the term because it provides
a specific, evidence-backed microtubule, tubulin-binding, localization, or tau-phosphorylation
annotation rather than only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0030426
label: growth cone
evidence_type: IDA
original_reference_id: PMID:8642405
qualifier: located_in
review:
summary: >-
growth cone is retained as a core cellular-component/localization annotation
for MAPT; it captures site of action or component context within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0030426 (growth cone), the IDA annotation with qualifier located_in from
PMID:8642405 is consistent with MAPT's core role in tau binding to tubulin and
microtubules, regulation of microtubule assembly and stability, axonal localization,
and tau phosphorylation-state biology. This action keeps the term because it
provides a specific, evidence-backed microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation rather than only a downstream phenotype or
generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0031113
label: regulation of microtubule polymerization
evidence_type: NAS
original_reference_id: PMID:1057175
qualifier: involved_in
review:
summary: >-
regulation of microtubule polymerization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0031113 (regulation of microtubule polymerization), the NAS annotation
with qualifier involved_in from PMID:1057175 is consistent with MAPT's core
role in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0031116
label: positive regulation of microtubule polymerization
evidence_type: IDA
original_reference_id: PMID:1421571
qualifier: involved_in
review:
summary: >-
positive regulation of microtubule polymerization is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0031116 (positive regulation of microtubule polymerization), the IDA
annotation with qualifier involved_in from PMID:1421571 is consistent with MAPT's
core role in tau binding to tubulin and microtubules, regulation of microtubule
assembly and stability, axonal localization, and tau phosphorylation-state biology.
This action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0045298
label: tubulin complex
evidence_type: IDA
original_reference_id: PMID:8642405
qualifier: part_of
review:
summary: >-
tubulin complex is directionally related to MAPT biology but is not the best
curation target; tubulin binding better captures the specific supported function
or process.
action: MODIFY
reason: >-
For GO:0045298 (tubulin complex), the IDA annotation with qualifier part_of
from PMID:8642405 supports a relationship to MAPT, but the current term is less
precise than tubulin binding for the evidence and for the synthesized core/non-core
role of MAPT. The MODIFY action preserves the biological intent while pointing
curators to the more informative GO term.
proposed_replacement_terms:
- id: GO:0015631
label: tubulin binding
additional_reference_ids:
- PMID:15147841
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0045773
label: positive regulation of axon extension
evidence_type: IDA
original_reference_id: PMID:1389180
qualifier: involved_in
review:
summary: >-
positive regulation of axon extension is retained as a core biological-process
annotation for MAPT; it captures process participation within the synthesized
core biology: tau microtubule binding, microtubule assembly/stability, axonal
and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: ACCEPT
reason: >-
For GO:0045773 (positive regulation of axon extension), the IDA annotation with
qualifier involved_in from PMID:1389180 is consistent with MAPT's core role
in tau binding to tubulin and microtubules, regulation of microtubule assembly
and stability, axonal localization, and tau phosphorylation-state biology. This
action keeps the term because it provides a specific, evidence-backed microtubule,
tubulin-binding, localization, or tau-phosphorylation annotation rather than
only a downstream phenotype or generic interaction label.
additional_reference_ids:
- PMID:15147841
- PMID:10747907
- PMID:2484340
- file:human/MAPT/MAPT-uniprot.txt
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15953362
qualifier: enables
review:
summary: >-
protein binding is marked over-annotated for MAPT because this molecular-function
term is too generic, interaction-map-like, or weakly informative relative to
the gene-specific biology: tau microtubule binding, microtubule assembly/stability,
axonal and neuronal projection localization, and phosphorylation-dependent regulation
of tau behavior.
action: MARK_AS_OVER_ANNOTATED
reason: >-
For GO:0005515 (protein binding), the IPI annotation with qualifier enables
from PMID:15953362 may reflect a real assay result or interaction, but this
GO term does not identify the specific microtubule, tubulin-binding, localization,
or tau-phosphorylation annotation that explains MAPT's role in tau binding to
tubulin and microtubules, regulation of microtubule assembly and stability,
axonal localization, and tau phosphorylation-state biology. More informative
gene-specific annotations are present, so this is marked over-annotated rather
than accepted as a core function.
additional_reference_ids:
- file:human/MAPT/MAPT-notes.md
references:
- id: GO_REF:0000002
title: Gene Ontology annotation through association of InterPro records with
GO terms
findings: []
- id: GO_REF:0000024
title: Manual transfer of experimentally-verified manual GO annotation data to
orthologs by curator judgment of sequence similarity
findings: []
- id: GO_REF:0000033
title: Annotation inferences using phylogenetic trees
findings: []
- id: GO_REF:0000044
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular
Location vocabulary mapping, accompanied by conservative changes to GO terms
applied by UniProt
findings: []
- id: GO_REF:0000052
title: Gene Ontology annotation based on curation of immunofluorescence data
findings: []
- id: GO_REF:0000108
title: Automatic assignment of GO terms using logical inference, based on on
inter-ontology links
findings: []
- id: PMID:1057175
title: A protein factor essential for microtubule assembly.
findings: []
- id: PMID:10640627
title: Regulation of phosphorylation of neuronal microtubule-associated
proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.
findings: []
- id: PMID:10747907
title: Interaction of tau with the neural membrane cortex is regulated by
phosphorylation at sites that are modified in paired helical filaments.
findings: []
reference_review:
relevance: HIGH
correctness: VERIFIED
review_notes: Primary study supporting axonal tau association with the
neural membrane cortex and phosphorylation-sensitive membrane association.
- id: PMID:10987820
title: Tau promoter confers neuronal specificity and binds Sp1 and AP-2.
findings: []
- id: PMID:12888622
title: 'Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in
Alzheimer''s disease.'
findings: []
- id: PMID:1389180
title: Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor
neurite formation.
findings: []
- id: PMID:1421571
title: Modulation of the dynamic instability of tubulin assembly by the
microtubule-associated protein tau.
findings: []
- id: PMID:14769047
title: Tau paired helical filaments from Alzheimer's disease brain and
assembled in vitro are based on beta-structure in the core domain.
findings: []
- id: PMID:15121898
title: The composition of Staufen-containing RNA granules from human cells
indicates their role in the regulated transport and translation of messenger
RNAs.
findings: []
- id: PMID:15147841
title: Surface-decoration of microtubules by human tau.
findings: []
reference_review:
relevance: HIGH
correctness: VERIFIED
review_notes: Primary structural/microtubule study supporting tau
microtubule surface binding and microtubule stabilization.
- id: PMID:15654759
title: 'Residual structure in the repeat domain of tau: echoes of microtubule binding
and paired helical filament formation.'
findings: []
- id: PMID:15953362
title: Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal
degradation.
findings: []
- id: PMID:16275660
title: Identification of VCP/p97, carboxyl terminus of Hsp70-interacting
protein (CHIP), and amphiphysin II interaction partners using membrane-based
human proteome arrays.
findings: []
- id: PMID:16446437
title: Abeta and tau form soluble complexes that may promote self aggregation
of both into the insoluble forms observed in Alzheimer's disease.
findings: []
- id: PMID:16923168
title: Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate,
is involved in tau phosphorylation and aggregation.
findings: []
- id: PMID:17270732
title: Synapse loss and microglial activation precede tangles in a P301S
tauopathy mouse model.
findings: []
- id: PMID:17317006
title: 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in
HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on
Ser9.
findings: []
- id: PMID:17517623
title: Roles of heat-shock protein 90 in maintaining and facilitating the
neurodegenerative phenotype in tauopathies.
findings: []
- id: PMID:17906291
title: DYRK1A-mediated hyperphosphorylation of Tau. A functional link between
Down syndrome and Alzheimer disease.
findings: []
- id: PMID:18272392
title: Extracellular tau promotes intracellular calcium increase through M1
and M3 muscarinic receptors in neuronal cells.
findings: []
- id: PMID:18292230
title: Akt and CHIP coregulate tau degradation through coordinated
interactions.
findings: []
- id: PMID:19074461
title: Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and
implicates autophagy in pathogenesis.
findings: []
- id: PMID:19138662
title: Effect of phosphorylation on interaction of human tau protein with
14-3-3zeta.
findings: []
- id: PMID:19157893
title: Fluorescence microscopy and 3D image reconstruction of cytokine
initiated disruption of the Parkinson disease associated proteins
alpha-synuclein, tau and ubiquitin in cultured glial cells.
findings: []
- id: PMID:1918161
title: Tau protein binds to microtubules through a flexible array of
distributed weak sites.
findings: []
- id: PMID:19457097
title: Tau--an inhibitor of deacetylase HDAC6 function.
findings: []
- id: PMID:19527721
title: Excitatory amino acid transporter 2 associates with phosphorylated tau
and is localized in neurofibrillary tangles of tauopathic brains.
findings: []
- id: PMID:19647741
title: Phosphorylation of more than one site is required for tight interaction
of human tau protein with 14-3-3zeta.
findings: []
- id: PMID:20133804
title: A role for FKBP52 in Tau protein function.
findings: []
- id: PMID:20655099
title: Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's
disease mouse models.
findings: []
reference_review:
relevance: MEDIUM
correctness: VERIFIED
review_notes: Primary AD mouse-model paper supporting tau-dependent
dendritic/Fyn/synaptic and memory phenotypes, kept as non-core downstream
disease context.
- id: PMID:21131359
title: Nuclear tau, a key player in neuronal DNA protection.
findings: []
- id: PMID:21692989
title: Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2
domains, but not SH3 domains, altering the cellular localization of tau.
findings: []
- id: PMID:21854751
title: Tau accumulation causes mitochondrial distribution deficits in neurons
in a mouse model of tauopathy and in human Alzheimer's disease brain.
findings: []
- id: PMID:22367970
title: 'Abnormal interaction between the mitochondrial fission protein Drp1 and
hyperphosphorylated tau in Alzheimer''s disease neurons: implications for mitochondrial
dysfunction and neuronal damage.'
findings: []
- id: PMID:22920254
title: Tau promotes neurodegeneration via DRP1 mislocalization in vivo.
findings: []
reference_review:
relevance: MEDIUM
correctness: VERIFIED
review_notes: Full-text primary tauopathy model paper supporting
actin-mediated mitochondrial dynamics phenotypes, kept as non-core
downstream toxicity context.
- id: PMID:23164821
title: Clusterin regulates Ξ²-amyloid toxicity via Dickkopf-1-driven induction
of the wnt-PCP-JNK pathway.
findings: []
- id: PMID:23362255
title: Isomerase Pin1 stimulates dephosphorylation of tau protein at
cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites.
findings: []
- id: PMID:23399914
title: Increased expression of BIN1 mediates Alzheimer genetic risk by
modulating tau pathology.
findings: []
- id: PMID:23589030
title: Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles
and is cleaved in Alzheimer's brains.
findings: []
- id: PMID:23666762
title: Role of individual MARK isoforms in phosphorylation of tau at SerΒ²βΆΒ² in
Alzheimer's disease.
findings: []
- id: PMID:24028865
title: Impact of the cellular prion protein on amyloid-Ξ² and 3PO-tau
processing.
findings: []
- id: PMID:24251416
title: Phosphorylation of human Tau protein by microtubule affinity-regulating
kinase 2.
findings: []
- id: PMID:2484340
title: 'Multiple isoforms of human microtubule-associated protein tau: sequences
and localization in neurofibrillary tangles of Alzheimer''s disease.'
findings: []
reference_review:
relevance: HIGH
correctness: VERIFIED
review_notes: Primary human tau isoform paper supporting incorporation of
multiple tau isoforms into Alzheimer neurofibrillary tangles.
- id: PMID:25051234
title: Intracellular clusterin interacts with brain isoforms of the bridging
integrator 1 and with the microtubule-associated protein Tau in Alzheimer's
disease.
findings: []
- id: PMID:25156556
title: AlphaScreen HTS and live-cell bioluminescence resonance energy transfer
(BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for
Alzheimer disease.
findings: []
- id: PMID:25556849
title: 'A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase
1A) inhibitor for the treatment of Alzheimer''s disease: effect on Tau and amyloid
pathologies in vitro.'
findings: []
- id: PMID:25620700
title: A genome-wide gene-expression analysis and database in transgenic mice
during development of amyloid or tau pathology.
findings: []
- id: PMID:26014385
title: LRRK2 Promotes Tau Accumulation, Aggregation and Release.
findings: []
- id: PMID:26363795
title: 'The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and
Therapy.'
findings: []
reference_review:
relevance: MEDIUM
correctness: VERIFIED
review_notes: Review supporting MAPT roles in neurodegenerative disease,
microtubules, axonal transport, and neurofibrillary tangles.
- id: PMID:26402096
title: Identification of Novel Tau Interactions with Endoplasmic Reticulum
Proteins in Alzheimer's Disease Brain.
findings: []
- id: PMID:26609151
title: Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and
Instability of Postsynaptic Density Proteins in Mice Lacking
Microtubule-Associated Protein 1A.
findings: []
- id: PMID:26996940
title: Regulation of Microtubule Assembly by Tau and not by Pin1.
findings: []
- id: PMID:27044754
title: FRMD4A-cytohesin signaling modulates the cellular release of tau.
findings: []
- id: PMID:27306859
title: Tau physiology and pathomechanisms in frontotemporal lobar
degeneration.
findings: []
- id: PMID:27356871
title: Acetylated tau destabilizes the cytoskeleton in the axon initial
segment and is mislocalized to the somatodendritic compartment.
findings: []
- id: PMID:28377597
title: Dyrk1A overexpression leads to increase of 3R-tau expression and
cognitive deficits in Ts65Dn Down syndrome mice.
findings: []
- id: PMID:28386764
title: Roles of tau protein in health and disease.
findings: []
reference_review:
relevance: MEDIUM
correctness: VERIFIED
review_notes: Full-text review supporting broad tau health/disease biology;
useful for secondary pathway context but not sufficient to make all broad
review-derived terms core.
- id: PMID:28650319
title: Somatostatin binds to the human amyloid Ξ² peptide and favors the
formation of distinct oligomers.
findings: []
- id: PMID:28755476
title: Regulation of the interaction between the neuronal BIN1 isoform 1 and
Tau proteins - role of the SH3 domain.
findings: []
- id: PMID:29764935
title: The disorderly conduct of Hsc70 and its interaction with the
Alzheimer's-related Tau protein.
findings: []
- id: PMID:30158706
title: Structures of filaments from Pick's disease reveal a novel tau protein
fold.
findings: []
- id: PMID:30668577
title: Role of tau N-terminal motif in the secretion of human tau by End
Binding proteins.
findings: []
- id: PMID:30894745
title: Novel tau filament fold in chronic traumatic encephalopathy encloses
hydrophobic molecules.
findings: []
- id: PMID:3111527
title: 'Comparison of S100b protein with calmodulin: interactions with melittin
and microtubule-associated tau proteins and inhibition of phosphorylation of tau
proteins by protein kinase C.'
findings: []
- id: PMID:31640277
title: GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but
Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal
Fluid and iPS Cells in Alzheimer Disease.
findings: []
- id: PMID:32272059
title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein
Secretion.
findings: []
reference_review:
relevance: LOW
correctness: VERIFIED
review_notes: Primary unconventional secretion paper supporting
extracellular/secreted tau context through leaderless cargo secretion, not
the core tau function.
- id: PMID:32814053
title: Interactome Mapping Provides a Network of Neurodegenerative Disease
Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
findings: []
- id: PMID:33961781
title: Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome.
findings: []
- id: PMID:34757590
title: Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative
Stress in Amyotrophic Lateral Sclerosis.
findings: []
- id: PMID:7566652
title: ApoE3 binding to tau tandem repeat I is abolished by tau serine262
phosphorylation.
findings: []
- id: PMID:7706316
title: Microtubule-associated protein/microtubule affinity-regulating kinase
(p110mark). A novel protein kinase that regulates tau-microtubule
interactions and dynamic instability by phosphorylation at the
Alzheimer-specific site serine 262.
findings: []
reference_review:
relevance: HIGH
correctness: VERIFIED
review_notes: Primary study supporting phosphorylation-dependent reduction
of tau microtubule binding and microtubule dynamic instability.
- id: PMID:7929085
title: Structural studies of tau protein and Alzheimer paired helical
filaments show no evidence for beta-structure.
findings: []
- id: PMID:7972031
title: 'Isoform-specific interactions of apolipoprotein E with microtubule-associated
protein tau: implications for Alzheimer disease.'
findings: []
- id: PMID:8522593
title: Interaction of tau with the neural plasma membrane mediated by tau's
amino-terminal projection domain.
findings: []
- id: PMID:8642405
title: Tau is enriched on dynamic microtubules in the distal region of growing
axons.
findings: []
- id: PMID:9689133
title: Presenilin 1 associates with glycogen synthase kinase-3beta and its
substrate tau.
findings: []
- id: PMID:9736630
title: Tau cleavage and dephosphorylation in cerebellar granule neurons
undergoing apoptosis.
findings: []
- id: PMID:9763511
title: Tau interacts with src-family non-receptor tyrosine kinases.
findings: []
- id: Reactome:R-HSA-201629
title: Caspase-mediated cleavage of Tau
findings: []
- id: Reactome:R-HSA-9836404
title: p-PKR dimer phosphorylates MAPT
findings: []
- id: Reactome:R-NUL-9619534
title: AMPK phosphorylates Mapt
findings: []
- id: Reactome:R-NUL-9619539
title: AMPK-negatively regulates binding of MAPT to microtubules
findings: []
- id: file:human/MAPT/MAPT-uniprot.txt
title: UniProt text export for MAPT (P10636)
findings: []
reference_review:
relevance: HIGH
correctness: VERIFIED
review_notes: Local UniProt record directly summarizes tau microtubule
assembly/stability, neuronal polarity, axonal microtubule binding,
membrane-component binding, subcellular localization, and tubulin-repeat
domain biology.
- id: file:human/MAPT/MAPT-notes.md
title: Manual MAPT review notes
findings: []
reference_review:
relevance: MEDIUM
correctness: VERIFIED
review_notes: Manual notes document the deep-research timeout and summarize
the cached UniProt, PANTHER, GOA, and publication evidence used for this
review.
core_functions:
- description: 'Neuronal microtubule-associated protein activity: tau binds tubulin
and microtubules, stabilizes microtubules, promotes microtubule assembly, supports
axonal microtubule organization, axonal transport, neurite/axon development, and
links axonal microtubules to neural membrane-cortex components.'
supported_by:
- reference_id: file:human/MAPT/MAPT-uniprot.txt
supporting_text: Promotes microtubule assembly and stability
- reference_id: file:human/MAPT/MAPT-uniprot.txt
supporting_text: The C-terminus binds axonal microtubules
- reference_id: file:human/MAPT/MAPT-uniprot.txt
supporting_text: N-terminus binds neural plasma membrane components
- reference_id: PMID:15147841
supporting_text: Tau is a neuronal, microtubule-associated protein
- reference_id: PMID:15147841
supporting_text: bind exclusively to the outside of microtubules
molecular_function:
id: GO:0140778
label: microtubule stabilizing activity
directly_involved_in:
- id: GO:0000226
label: microtubule cytoskeleton organization
- id: GO:0031116
label: positive regulation of microtubule polymerization
- id: GO:0031175
label: neuron projection development
- id: GO:0098930
label: axonal transport
locations:
- id: GO:0015630
label: microtubule cytoskeleton
- id: GO:0030424
label: axon
- id: GO:0005829
label: cytosol
- id: GO:0005886
label: plasma membrane
- description: Disease-relevant tau self-association and pathological
filament/tangle assembly, in which modified tau proteins polymerize into
supramolecular fibers, amyloid-like paired helical filaments, and Alzheimer
neurofibrillary tangles.
supported_by:
- reference_id: PMID:2484340
supporting_text: multiple tau protein isoforms are incorporated into
- reference_id: PMID:2484340
supporting_text: neurofibrillary tangles of Alzheimer's disease
- reference_id: PMID:26363795
supporting_text: neurofibrillary tangles (NFTs)
- reference_id: PMID:28386764
supporting_text: aberrant assembly of tau into insoluble
molecular_function:
id: GO:0042802
label: identical protein binding
directly_involved_in:
- id: GO:1990000
label: amyloid fibril formation
- id: GO:0097435
label: supramolecular fiber organization
- id: GO:1902988
label: neurofibrillary tangle assembly
locations:
- id: GO:0097418
label: neurofibrillary tangle
proposed_new_terms: []
suggested_questions:
- question: Which tau annotations should be treated as normal neuronal
microtubule/axon biology versus pathological tauopathy gain-of-function or
mislocalization?
- question: Which kinase-, phosphatase-, chaperone-, lipid-, and
APOE-interaction annotations are reproducible endogenous tau functions
rather than context-specific or high-throughput interactions?
- question: For Alzheimer-relevant pathway modules, should extracellular tau
secretion/spread, synaptic toxicity, mitochondrial dysfunction, and glial
activation be curated as MAPT core functions or as downstream
disease-context consequences?
suggested_experiments:
- hypothesis: Tau phosphorylation state determines the balance between axonal
microtubule stabilization, neural membrane-cortex association, and
somatodendritic mislocalization.
description: Use endogenous MAPT isoform and phosphosite editing in human
iPSC-derived neurons, followed by live imaging of microtubule dynamics,
axonal transport, membrane-cortex association, and somatodendritic tau
accumulation under amyloid and kinase-activation stressors.
experiment_type: endogenous phosphosite/isoform perturbation assay
- hypothesis: Pathological tau self-assembly is separable from normal
microtubule-stabilizing activity and drives downstream synaptic and
mitochondrial phenotypes.
description: Compare wild-type tau with aggregation-defective and
microtubule-binding-defective MAPT variants in neuronal cultures, measuring
tau filament formation, neurofibrillary-tangle markers, synapse
localization/function, mitochondrial transport, and neuron viability.
experiment_type: structure-function tauopathy model