GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB O15553 MEFV is_active_in GO:0005737 cytoplasm cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:106657|MGI:MGI:1337056|MGI:MGI:1338757|MGI:MGI:1913847|MGI:MGI:1914104|MGI:MGI:1923931|MGI:MGI:2137352|MGI:MGI:2137353|MGI:MGI:2137355|MGI:MGI:3612190|MGI:MGI:97904|MGI:MGI:98178|PANTHER:PTN007774218|RGD:1304877|RGD:619964|RGD:708400|UniProtKB:O15553|UniProtKB:O60858|UniProtKB:O75677|UniProtKB:P14373|UniProtKB:P19474|UniProtKB:Q0PF16|UniProtKB:Q12899|UniProtKB:Q14142|UniProtKB:Q5W0U4|UniProtKB:Q6AZZ1|UniProtKB:Q6P9F5|UniProtKB:Q86WT6|UniProtKB:Q8IWZ4|UniProtKB:Q8IYM9|UniProtKB:Q8WV44|UniProtKB:Q969Q1|UniProtKB:Q96A61|UniProtKB:Q96F44|UniProtKB:Q9BVG3|UniProtKB:Q9BYJ4|UniProtKB:Q9BZY9|UniProtKB:Q9C029|UniProtKB:Q9C030|UniProtKB:Q9C035|UniProtKB:Q9C037|UniProtKB:Q9H2S5|UniProtKB:Q9HCM9 9606 Homo sapiens GO_Central Pyrin 20251220 UniProtKB O15553 MEFV involved_in GO:0045087 innate immune response biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338757|MGI:MGI:2137355|MGI:MGI:2385051|MGI:MGI:97904|PANTHER:PTN000762195|UniProtKB:O15553|UniProtKB:O60858|UniProtKB:P14373|UniProtKB:P19474|UniProtKB:Q0PF16|UniProtKB:Q12899|UniProtKB:Q14142|UniProtKB:Q96F44|UniProtKB:Q9BVG3|UniProtKB:Q9BZY9|UniProtKB:Q9C019|UniProtKB:Q9C029|UniProtKB:Q9C030|UniProtKB:Q9C035|UniProtKB:Q9UPQ4 9606 Homo sapiens GO_Central Pyrin 20251220 UniProtKB O15553 MEFV involved_in GO:0010468 regulation of gene expression biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1859396|MGI:MGI:2137352|MGI:MGI:2137355|MGI:MGI:2684869|MGI:MGI:98178|PANTHER:PTN008394629|UniProtKB:O15553|UniProtKB:P19474|UniProtKB:Q9C030|UniProtKB:Q9C035 9606 Homo sapiens GO_Central Pyrin 20250903 UniProtKB O15553 MEFV enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000318 IBA GO_REF:0000033 MGI:MGI:2137355|MGI:MGI:2385051|MGI:MGI:2447992|MGI:MGI:2684862|MGI:MGI:2684869|MGI:MGI:3612190|PANTHER:PTN007774218|UniProtKB:P14373|UniProtKB:P19474|UniProtKB:Q12899|UniProtKB:Q86WT6|UniProtKB:Q8IWZ4|UniProtKB:Q8IYM9|UniProtKB:Q8WV44|UniProtKB:Q969Q1|UniProtKB:Q96A61|UniProtKB:Q9BVG3|UniProtKB:Q9BYV6|UniProtKB:Q9BZY9|UniProtKB:Q9C029|UniProtKB:Q9C030|UniProtKB:Q9H2S5 9606 Homo sapiens GO_Central Pyrin 20250903 UniProtKB O15553 MEFV is_active_in GO:0005829 cytosol cellular_component ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN004670165|UniProtKB:O15553 9606 Homo sapiens GO_Central Pyrin 20250412 UniProtKB O15553 MEFV located_in GO:0001726 ruffle cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0300 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV located_in GO:0005634 nucleus cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0191 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV located_in GO:0005737 cytoplasm cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV located_in GO:0005776 autophagosome cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0023 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV located_in GO:0005856 cytoskeleton cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0090 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV enables GO:0008270 zinc ion binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000315 9606 Homo sapiens InterPro Pyrin 20260601 UniProtKB O15553 MEFV located_in GO:0030027 lamellipodium cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0291 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV involved_in GO:0032731 positive regulation of interleukin-1 beta production biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00033916 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV involved_in GO:0050727 regulation of inflammatory response biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00045047 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV involved_in GO:0051707 response to other organism biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00029118 9606 Homo sapiens UniProt Pyrin 20260601 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:11498534 UniProtKB:Q9ULZ3 9606 Homo sapiens IntAct Pyrin 20260530 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:16785446 UniProtKB:P29466 9606 Homo sapiens IntAct Pyrin 20260530 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:17964261 UniProtKB:O43586 9606 Homo sapiens IntAct Pyrin 20260530 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:17964261 UniProtKB:Q9ULZ3 9606 Homo sapiens IntAct Pyrin 20260530 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25006247 UniProtKB:Q9ULZ3 9606 Homo sapiens IntAct Pyrin 20260530 UniProtKB O15553 MEFV enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:17964261 UniProtKB:O15553 9606 Homo sapiens IntAct Pyrin 20260530 UniProtKB O15553 MEFV enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:22829933 UniProtKB:O15553 9606 Homo sapiens IntAct Pyrin 20260530 UniProtKB O15553 MEFV enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:25006247 UniProtKB:O15553 9606 Homo sapiens IntAct Pyrin 20260530 UniProtKB O15553 MEFV located_in GO:0005886 plasma membrane cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Pyrin 20251115 UniProtKB O15553 MEFV located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:10666224 9606 Homo sapiens UniProt Pyrin 20251027 UniProtKB O15553 MEFV located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:11498534 9606 Homo sapiens UniProt Pyrin 20251027 UniProtKB O15553 MEFV located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:18577712 9606 Homo sapiens UniProt Pyrin 20251027 UniProtKB O15553 MEFV located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:19584923 9606 Homo sapiens UniProt Pyrin 20251027 UniProtKB O15553 MEFV involved_in GO:0002221 pattern recognition receptor signaling pathway biological_process ECO:0005547 NAS PMID:29196474 9606 Homo sapiens ComplexPortal Pyrin 20250804 UniProtKB O15553 MEFV located_in GO:0005874 microtubule cellular_component ECO:0005547 NAS PMID:27911804 9606 Homo sapiens ComplexPortal Pyrin 20250804 UniProtKB O15553 MEFV involved_in GO:0032731 positive regulation of interleukin-1 beta production biological_process ECO:0000314 IDA PMID:16037825 9606 Homo sapiens ComplexPortal Pyrin 20250804 UniProtKB O15553 MEFV part_of GO:0061702 canonical inflammasome complex cellular_component ECO:0000353 IPI PMID:16037825 9606 Homo sapiens ComplexPortal Pyrin 20250804 UniProtKB O15553 MEFV involved_in GO:0070269 pyroptotic inflammatory response biological_process ECO:0005547 NAS PMID:29196474 9606 Homo sapiens ComplexPortal Pyrin 20250804 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:27030597 UniProtKB:P27348|UniProtKB:P31946|UniProtKB:P61981|UniProtKB:P62258|UniProtKB:P63104|UniProtKB:Q04917 9606 Homo sapiens UniProt Pyrin 20210210 UniProtKB O15553 MEFV involved_in GO:0032651 regulation of interleukin-1 beta production biological_process ECO:0000315 IMP PMID:27030597 9606 Homo sapiens UniProt Pyrin 20210210 UniProtKB O15553 MEFV involved_in GO:1904270 pyroptosome complex assembly biological_process ECO:0000314 IDA PMID:27030597 9606 Homo sapiens UniProt Pyrin 20210210 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:26347139 UniProtKB:O75385|UniProtKB:O95166|UniProtKB:P19474|UniProtKB:P60520|UniProtKB:Q14457|UniProtKB:Q676U5|UniProtKB:Q96P20|UniProtKB:Q9BXW4|UniProtKB:Q9H0R8|UniProtKB:Q9H492 9606 Homo sapiens UniProt Pyrin 20151029 UniProtKB O15553 MEFV located_in GO:0005737 cytoplasm cellular_component ECO:0000314 IDA PMID:26347139 9606 Homo sapiens UniProt Pyrin 20151029 UniProtKB O15553 MEFV involved_in GO:0010508 positive regulation of autophagy biological_process ECO:0000314 IDA PMID:26347139 9606 Homo sapiens UniProt Pyrin 20151029 UniProtKB O15553 MEFV involved_in GO:0034341 response to type II interferon biological_process ECO:0000314 IDA PMID:26347139 9606 Homo sapiens UniProt Pyrin 20151029 UniProtKB O15553 MEFV involved_in GO:1900016 negative regulation of cytokine production involved in inflammatory response biological_process ECO:0000315 IMP PMID:26347139 9606 Homo sapiens UniProt Pyrin 20151029 UniProtKB O15553 MEFV involved_in GO:1900226 negative regulation of NLRP3 inflammasome complex assembly biological_process ECO:0000315 IMP PMID:26347139 9606 Homo sapiens UniProt Pyrin 20151029 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:O95166 9606 Homo sapiens UniProt Pyrin 20150715 UniProtKB O15553 MEFV enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:Q9H492 9606 Homo sapiens UniProt Pyrin 20150715 UniProtKB O15553 MEFV located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-877361 9606 Homo sapiens Reactome Pyrin 20130528 UniProtKB O15553 MEFV located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-879221 9606 Homo sapiens Reactome Pyrin 20130528 UniProtKB O15553 MEFV involved_in GO:0032691 negative regulation of interleukin-1 beta production biological_process ECO:0000315 IMP PMID:20041150 9606 Homo sapiens BHF-UCL Pyrin 20120622 UniProtKB O15553 MEFV involved_in GO:0032695 negative regulation of interleukin-12 production biological_process ECO:0000315 IMP PMID:20041150 9606 Homo sapiens BHF-UCL Pyrin 20120622 UniProtKB O15553 MEFV involved_in GO:0050728 negative regulation of inflammatory response biological_process ECO:0000315 IMP PMID:16403826 9606 Homo sapiens BHF-UCL Pyrin 20120622 UniProtKB O15553 MEFV involved_in GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production biological_process ECO:0000315 IMP PMID:20041150 9606 Homo sapiens BHF-UCL Pyrin 20120622 UniProtKB O15553 MEFV enables GO:0003779 actin binding molecular_function ECO:0000314 IDA PMID:11468188 9606 Homo sapiens UniProt Pyrin 20021202 UniProtKB O15553 MEFV located_in GO:0005634 nucleus cellular_component ECO:0000314 IDA PMID:11115844 9606 Homo sapiens UniProt Pyrin 20021202 UniProtKB O15553 MEFV part_of GO:0005875 microtubule associated complex cellular_component ECO:0000314 IDA PMID:11468188 9606 Homo sapiens UniProt Pyrin 20021202 UniProtKB O15553 MEFV involved_in GO:0006954 inflammatory response biological_process ECO:0000314 IDA PMID:11468188 9606 Homo sapiens UniProt Pyrin 20021202 UniProtKB O15553 MEFV enables GO:0008270 zinc ion binding molecular_function ECO:0000303 NAS PMID:11115844 9606 Homo sapiens UniProt Pyrin 20021202