MORC3

id: Q14149
gene_symbol: MORC3
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for MORC3'
existing_annotations:
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140002
      label: histone H3K4me3 reader activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140374
      label: antiviral innate immune response
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016605
      label: PML body
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006325
      label: chromatin organization
    evidence_type: IEA
    original_reference_id: GO_REF:0000108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002376
      label: immune system process
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003723
      label: RNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005694
      label: chromosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008270
      label: zinc ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016363
      label: nuclear matrix
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016605
      label: PML body
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016887
      label: ATP hydrolysis activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045087
      label: innate immune response
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140002
      label: histone H3K4me3 reader activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26496610
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26496610
          supporting_text: Oct 22. A human interactome in three quantitative 
            dimensions organized by stoichiometries and abundances.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:27173435
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27173435
          supporting_text: An organelle-specific protein landscape identifies 
            novel diseases and molecular mechanisms.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:35271311
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:35271311
          supporting_text: '2022 Mar 11. OpenCell: Endogenous tagging for the cartography
            of human cellular organization.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:35914814
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:35914814
          supporting_text: "Chr21 protein-protein interactions: enrichment in proteins
            involved in intellectual disability, autism, and late-onset Alzheimer's
            disease."
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:40205054
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:40205054
          supporting_text: Apr 9. Multimodal cell maps as a foundation for 
            structural and functional genomics.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140002
      label: histone H3K4me3 reader activity
    evidence_type: IDA
    original_reference_id: PMID:26933034
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26933034
          supporting_text: 2016 Mar 1. Family-wide Characterization of Histone 
            Binding Abilities of Human CW Domain-containing Proteins.
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:34759314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:34759314
          supporting_text: Nov 10. Self-guarding of MORC3 enables virulence 
            factor-triggered immunity.
  - term:
      id: GO:0000785
      label: chromatin
    evidence_type: IDA
    original_reference_id: PMID:34759314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:34759314
          supporting_text: Nov 10. Self-guarding of MORC3 enables virulence 
            factor-triggered immunity.
  - term:
      id: GO:0003677
      label: DNA binding
    evidence_type: IDA
    original_reference_id: PMID:34759314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:34759314
          supporting_text: Nov 10. Self-guarding of MORC3 enables virulence 
            factor-triggered immunity.
  - term:
      id: GO:0016605
      label: PML body
    evidence_type: IDA
    original_reference_id: PMID:27440897
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27440897
          supporting_text: MORC3, a Component of PML Nuclear Bodies, Has a Role 
            in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.
  - term:
      id: GO:0030674
      label: protein-macromolecule adaptor activity
    evidence_type: IDA
    original_reference_id: PMID:27440897
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27440897
          supporting_text: MORC3, a Component of PML Nuclear Bodies, Has a Role 
            in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.
  - term:
      id: GO:0032688
      label: negative regulation of interferon-beta production
    evidence_type: IDA
    original_reference_id: PMID:34759314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:34759314
          supporting_text: Nov 10. Self-guarding of MORC3 enables virulence 
            factor-triggered immunity.
  - term:
      id: GO:0140374
      label: antiviral innate immune response
    evidence_type: IDA
    original_reference_id: PMID:27440897
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27440897
          supporting_text: MORC3, a Component of PML Nuclear Bodies, Has a Role 
            in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.
  - term:
      id: GO:2000774
      label: positive regulation of cellular senescence
    evidence_type: IDA
    original_reference_id: PMID:17332504
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17332504
          supporting_text: Mar 1. Dynamic regulation of p53 subnuclear 
            localization and senescence by MORC3.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:17332504
    review:
      summary: >-
        MISANNOTATION: MORC3 is a GHL-ATPase (not a kinase) that regulates p53 recruitment
        to PML-NBs. PMID:17332504 explicitly states "genotoxic stress-induced phosphorylation
        and stabilization of p53 but barely increased its transcriptional activity
        in
        Morc3-/- fibroblasts" - this means p53 IS PHOSPHORYLATED even without MORC3.
        MORC3
        affects p53 activity DOWNSTREAM of phosphorylation through PML-NB recruitment,
        not by performing phosphorylation itself.
      action: REMOVE
      supported_by:
        - reference_id: PMID:17332504
          supporting_text: Mar 1. Dynamic regulation of p53 subnuclear 
            localization and senescence by MORC3.
  - term:
      id: GO:0016605
      label: PML body
    evidence_type: IDA
    original_reference_id: PMID:17332504
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17332504
          supporting_text: Mar 1. Dynamic regulation of p53 subnuclear 
            localization and senescence by MORC3.
  - term:
      id: GO:0018105
      label: peptidyl-serine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:17332504
    review:
      summary: >-
        MISANNOTATION: MORC3 is a GHL-ATPase domain protein, NOT a serine/threonine
        kinase. PMID:17332504 describes MORC3's role in p53 recruitment to PML-NBs
        and
        shows p53 phosphorylation occurs independently of MORC3 ("genotoxic stress-induced
        phosphorylation... in Morc3-/- fibroblasts"). MORC3 has ATPase activity but
        no
        kinase activity. The annotation incorrectly attributes phosphorylation catalysis
        to MORC3.
      action: REMOVE
      supported_by:
        - reference_id: PMID:17332504
          supporting_text: Mar 1. Dynamic regulation of p53 subnuclear 
            localization and senescence by MORC3.
  - term:
      id: GO:0048147
      label: negative regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:17332504
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17332504
          supporting_text: Mar 1. Dynamic regulation of p53 subnuclear 
            localization and senescence by MORC3.
  - term:
      id: GO:0050821
      label: protein stabilization
    evidence_type: IDA
    original_reference_id: PMID:17332504
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17332504
          supporting_text: Mar 1. Dynamic regulation of p53 subnuclear 
            localization and senescence by MORC3.
  - term:
      id: GO:0051457
      label: maintenance of protein location in nucleus
    evidence_type: IDA
    original_reference_id: PMID:17332504
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17332504
          supporting_text: Mar 1. Dynamic regulation of p53 subnuclear 
            localization and senescence by MORC3.
  - term:
      id: GO:0051457
      label: maintenance of protein location in nucleus
    evidence_type: IMP
    original_reference_id: PMID:17332504
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17332504
          supporting_text: Mar 1. Dynamic regulation of p53 subnuclear 
            localization and senescence by MORC3.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000108
    title: Automatic assignment of GO terms using logical inference, based on on
      inter-ontology links
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:17332504
    title: Dynamic regulation of p53 subnuclear localization and senescence by 
      MORC3.
    findings: []
  - id: PMID:26496610
    title: A human interactome in three quantitative dimensions organized by 
      stoichiometries and abundances.
    findings: []
  - id: PMID:26933034
    title: Family-wide Characterization of Histone Binding Abilities of Human CW
      Domain-containing Proteins.
    findings: []
  - id: PMID:27173435
    title: An organelle-specific protein landscape identifies novel diseases and
      molecular mechanisms.
    findings: []
  - id: PMID:27440897
    title: MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting 
      Herpes Simplex Virus 1 and Human Cytomegalovirus.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:34759314
    title: Self-guarding of MORC3 enables virulence factor-triggered immunity.
    findings: []
  - id: PMID:35271311
    title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
    findings: []
  - id: PMID:35914814
    title: 'Chr21 protein-protein interactions: enrichment in proteins involved in
      intellectual disability, autism, and late-onset Alzheimer''s disease.'
    findings: []
  - id: PMID:40205054
    title: Multimodal cell maps as a foundation for structural and functional 
      genomics.
    findings: []