MTMR9 is a catalytically inactive myotubularin-family protein that binds active myotubularins and regulates their activity, substrate preference and stability. Association with MTMR6 favors phosphatidylinositol-3,5-bisphosphate turnover, whereas association with MTMR8 regulates phosphatidylinositol-3-phosphate and autophagy. Its GRAM and phosphatase-like regions provide a conserved noncatalytic regulatory architecture.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005515 protein binding | IPI PMID:12890864 Characterization of myotubularin-related protein 7 and its b... | UNDECIDED | Summary: protein binding: The PMID:12890864 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:12890864 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: protein binding: The PMID:16189514 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:16189514 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: protein binding: The PMID:16189514 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:16189514 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:19447967 Shifted Transversal Design smart-pooling for high coverage i... | UNDECIDED | Summary: protein binding: The PMID:19447967 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:19447967 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | UNDECIDED | Summary: protein binding: The PMID:21516116 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:21516116 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | UNDECIDED | Summary: protein binding: The PMID:21516116 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:21516116 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:22647598 Myotubularin-related protein (MTMR) 9 determines the enzymat... | UNDECIDED | Summary: protein binding: The PMID:22647598 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:22647598 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:27880917 Phenotypic and Interaction Profiling of the Human Phosphatas... | UNDECIDED | Summary: protein binding: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:27880917 Phenotypic and Interaction Profiling of the Human Phosphatas... | UNDECIDED | Summary: protein binding: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:27880917 Phenotypic and Interaction Profiling of the Human Phosphatas... | UNDECIDED | Summary: protein binding: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | UNDECIDED | Summary: protein binding: The PMID:28514442 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:28514442 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | UNDECIDED | Summary: protein binding: The PMID:28514442 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:28514442 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | UNDECIDED | Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | UNDECIDED | Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | UNDECIDED | Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | UNDECIDED | Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | UNDECIDED | Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: protein binding: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: protein binding: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: protein binding: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | UNDECIDED | Summary: protein binding: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | UNDECIDED | Summary: protein binding: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | UNDECIDED | Summary: protein binding: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. |
| GO:0005737 cytoplasm | EXP PMID:19038970 MTMR9 increases MTMR6 enzyme activity, stability, and role i... | ACCEPT | Summary: cytoplasm: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: cytoplasm: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0005737 cytoplasm | IDA PMID:16787938 Systematic analysis of myotubularins: heteromeric interactio... | ACCEPT | Summary: cytoplasm: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: cytoplasm: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0005783 endoplasmic reticulum | EXP PMID:19038970 MTMR9 increases MTMR6 enzyme activity, stability, and role i... | KEEP AS NON CORE | Summary: endoplasmic reticulum: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function. Reason: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function. Supporting Evidence: file:human/MTMR9/MTMR9-uniprot.txt CC Partially localizes to the endoplasmic reticulum (PubMed:19038970). |
| GO:0005783 endoplasmic reticulum | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: endoplasmic reticulum: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function. Reason: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function. Supporting Evidence: file:human/MTMR9/MTMR9-uniprot.txt CC Partially localizes to the endoplasmic reticulum (PubMed:19038970). |
| GO:0005829 cytosol | IEA GO_REF:0000117 | ACCEPT | Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6809254 | ACCEPT | Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6809309 | ACCEPT | Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6809320 | ACCEPT | Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6809325 | ACCEPT | Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0006661 phosphatidylinositol biosynthetic process | TAS Reactome:R-HSA-1660499 | UNDECIDED | Summary: phosphatidylinositol biosynthetic process: MTMR complexes interconvert phosphoinositides through dephosphorylation. The specific Reactome phosphatidylinositol biosynthesis placement should be traced to its reaction rather than inferred from generic phosphoinositide involvement. Reason: MTMR complexes interconvert phosphoinositides through dephosphorylation. The specific Reactome phosphatidylinositol biosynthesis placement should be traced to its reaction rather than inferred from generic phosphoinositide involvement. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0010507 negative regulation of autophagy | IBA GO_REF:0000033 | ACCEPT | Summary: negative regulation of autophagy: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity PMID:22647598 the MTMR8/R9 complex inhibits autophagy. |
| GO:0010507 negative regulation of autophagy | IPI PMID:22647598 Myotubularin-related protein (MTMR) 9 determines the enzymat... | ACCEPT | Summary: negative regulation of autophagy: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity PMID:22647598 the MTMR8/R9 complex inhibits autophagy. |
| GO:0010922 positive regulation of phosphatase activity | IDA PMID:22647598 Myotubularin-related protein (MTMR) 9 determines the enzymat... | ACCEPT | Summary: positive regulation of phosphatase activity: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity PMID:22647598 the MTMR8/R9 complex inhibits autophagy. |
| GO:0019211 phosphatase activator activity | EXP PMID:19038970 MTMR9 increases MTMR6 enzyme activity, stability, and role i... | ACCEPT | Summary: phosphatase activator activity: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity PMID:22647598 the MTMR8/R9 complex inhibits autophagy. |
| GO:0019211 phosphatase activator activity | EXP PMID:22647598 Myotubularin-related protein (MTMR) 9 determines the enzymat... | ACCEPT | Summary: phosphatase activator activity: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity PMID:22647598 the MTMR8/R9 complex inhibits autophagy. |
| GO:0019903 protein phosphatase binding | IBA GO_REF:0000033 | UNDECIDED | Summary: protein phosphatase binding: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity. Reason: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0019903 protein phosphatase binding | IPI PMID:16787938 Systematic analysis of myotubularins: heteromeric interactio... | UNDECIDED | Summary: protein phosphatase binding: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity. Reason: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0019903 protein phosphatase binding | IPI PMID:16787938 Systematic analysis of myotubularins: heteromeric interactio... | UNDECIDED | Summary: protein phosphatase binding: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity. Reason: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0030234 enzyme regulator activity | IEA GO_REF:0000120 | MODIFY | Summary: enzyme regulator activity: Direct experiments show phosphatase activation, a more informative MF than generic enzyme regulator activity. Reason: Direct experiments show phosphatase activation, a more informative MF than generic enzyme regulator activity. Proposed replacements: phosphatase activator activity Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0032587 ruffle membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: ruffle membrane: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function. Reason: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function. Supporting Evidence: file:human/MTMR9/MTMR9-uniprot.txt CC Partially localizes to the endoplasmic reticulum (PubMed:19038970). |
| GO:0032991 protein-containing complex | IDA PMID:22647598 Myotubularin-related protein (MTMR) 9 determines the enzymat... | KEEP AS NON CORE | Summary: protein-containing complex: Complex formation is experimentally established, but this generic complex term is too broad to identify the MTMR6βMTMR9 or MTMR8βMTMR9 machinery. Reason: Complex formation is experimentally established, but this generic complex term is too broad to identify the MTMR6βMTMR9 or MTMR8βMTMR9 machinery. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity |
| GO:0046856 phosphatidylinositol dephosphorylation | IBA GO_REF:0000033 | ACCEPT | Summary: phosphatidylinositol dephosphorylation: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity PMID:22647598 the MTMR8/R9 complex inhibits autophagy. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: perinuclear region of cytoplasm: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function. Reason: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function. Supporting Evidence: file:human/MTMR9/MTMR9-uniprot.txt CC Partially localizes to the endoplasmic reticulum (PubMed:19038970). |
| GO:0050821 protein stabilization | IDA PMID:22647598 Myotubularin-related protein (MTMR) 9 determines the enzymat... | ACCEPT | Summary: protein stabilization: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity PMID:22647598 the MTMR8/R9 complex inhibits autophagy. |
| GO:0060304 regulation of phosphatidylinositol dephosphorylation | IDA PMID:22647598 Myotubularin-related protein (MTMR) 9 determines the enzymat... | ACCEPT | Summary: regulation of phosphatidylinositol dephosphorylation: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8βMTMR9 inhibits autophagy in cell experiments. Supporting Evidence: PMID:22647598 Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity PMID:22647598 the MTMR8/R9 complex inhibits autophagy. |
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