MTMR9

UniProt ID: Q96QG7
Organism: Homo sapiens
Review Status: COMPLETE
πŸ“ Provide Detailed Feedback

Gene Description

MTMR9 is a catalytically inactive myotubularin-family protein that binds active myotubularins and regulates their activity, substrate preference and stability. Association with MTMR6 favors phosphatidylinositol-3,5-bisphosphate turnover, whereas association with MTMR8 regulates phosphatidylinositol-3-phosphate and autophagy. Its GRAM and phosphatase-like regions provide a conserved noncatalytic regulatory architecture.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005515 protein binding
IPI
PMID:12890864
Characterization of myotubularin-related protein 7 and its b...
UNDECIDED
Summary: protein binding: The PMID:12890864 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:12890864 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:16189514
Towards a proteome-scale map of the human protein-protein in...
UNDECIDED
Summary: protein binding: The PMID:16189514 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:16189514 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:16189514
Towards a proteome-scale map of the human protein-protein in...
UNDECIDED
Summary: protein binding: The PMID:16189514 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:16189514 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:19447967
Shifted Transversal Design smart-pooling for high coverage i...
UNDECIDED
Summary: protein binding: The PMID:19447967 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:19447967 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:21516116
Next-generation sequencing to generate interactome datasets.
UNDECIDED
Summary: protein binding: The PMID:21516116 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:21516116 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:21516116
Next-generation sequencing to generate interactome datasets.
UNDECIDED
Summary: protein binding: The PMID:21516116 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:21516116 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:22647598
Myotubularin-related protein (MTMR) 9 determines the enzymat...
UNDECIDED
Summary: protein binding: The PMID:22647598 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:22647598 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network.
UNDECIDED
Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network.
UNDECIDED
Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network.
UNDECIDED
Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network.
UNDECIDED
Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network.
UNDECIDED
Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network.
UNDECIDED
Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network.
UNDECIDED
Summary: protein binding: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:25416956 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:27880917
Phenotypic and Interaction Profiling of the Human Phosphatas...
UNDECIDED
Summary: protein binding: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:27880917
Phenotypic and Interaction Profiling of the Human Phosphatas...
UNDECIDED
Summary: protein binding: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:27880917
Phenotypic and Interaction Profiling of the Human Phosphatas...
UNDECIDED
Summary: protein binding: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:27880917 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:28514442
Architecture of the human interactome defines protein commun...
UNDECIDED
Summary: protein binding: The PMID:28514442 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:28514442 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:28514442
Architecture of the human interactome defines protein commun...
UNDECIDED
Summary: protein binding: The PMID:28514442 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:28514442 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:29892012
An interactome perturbation framework prioritizes damaging m...
UNDECIDED
Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:29892012
An interactome perturbation framework prioritizes damaging m...
UNDECIDED
Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:29892012
An interactome perturbation framework prioritizes damaging m...
UNDECIDED
Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:29892012
An interactome perturbation framework prioritizes damaging m...
UNDECIDED
Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:29892012
An interactome perturbation framework prioritizes damaging m...
UNDECIDED
Summary: protein binding: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:29892012 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:31515488
Extensive disruption of protein interactions by genetic vari...
UNDECIDED
Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:31515488
Extensive disruption of protein interactions by genetic vari...
UNDECIDED
Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:31515488
Extensive disruption of protein interactions by genetic vari...
UNDECIDED
Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:31515488
Extensive disruption of protein interactions by genetic vari...
UNDECIDED
Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:31515488
Extensive disruption of protein interactions by genetic vari...
UNDECIDED
Summary: protein binding: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:31515488 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome.
UNDECIDED
Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling...
UNDECIDED
Summary: protein binding: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling...
UNDECIDED
Summary: protein binding: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling...
UNDECIDED
Summary: protein binding: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:33961781 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func...
UNDECIDED
Summary: protein binding: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func...
UNDECIDED
Summary: protein binding: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func...
UNDECIDED
Summary: protein binding: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
Reason: The PMID:40205054 interaction annotation does not by itself identify a molecular role for MTMR9. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005737 cytoplasm
EXP
PMID:19038970
MTMR9 increases MTMR6 enzyme activity, stability, and role i...
ACCEPT
Summary: cytoplasm: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0005737 cytoplasm
IBA
GO_REF:0000033
ACCEPT
Summary: cytoplasm: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0005737 cytoplasm
IDA
PMID:16787938
Systematic analysis of myotubularins: heteromeric interactio...
ACCEPT
Summary: cytoplasm: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0005737 cytoplasm
IEA
GO_REF:0000044
ACCEPT
Summary: cytoplasm: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0005783 endoplasmic reticulum
EXP
PMID:19038970
MTMR9 increases MTMR6 enzyme activity, stability, and role i...
KEEP AS NON CORE
Summary: endoplasmic reticulum: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function.
Reason: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function.
Supporting Evidence:
file:human/MTMR9/MTMR9-uniprot.txt
CC Partially localizes to the endoplasmic reticulum (PubMed:19038970).
GO:0005783 endoplasmic reticulum
IEA
GO_REF:0000044
KEEP AS NON CORE
Summary: endoplasmic reticulum: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function.
Reason: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function.
Supporting Evidence:
file:human/MTMR9/MTMR9-uniprot.txt
CC Partially localizes to the endoplasmic reticulum (PubMed:19038970).
GO:0005829 cytosol
IEA
GO_REF:0000117
ACCEPT
Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0005829 cytosol
TAS
Reactome:R-HSA-6809254
ACCEPT
Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0005829 cytosol
TAS
Reactome:R-HSA-6809309
ACCEPT
Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0005829 cytosol
TAS
Reactome:R-HSA-6809320
ACCEPT
Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0005829 cytosol
TAS
Reactome:R-HSA-6809325
ACCEPT
Summary: cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Reason: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0006661 phosphatidylinositol biosynthetic process
TAS
Reactome:R-HSA-1660499
UNDECIDED
Summary: phosphatidylinositol biosynthetic process: MTMR complexes interconvert phosphoinositides through dephosphorylation. The specific Reactome phosphatidylinositol biosynthesis placement should be traced to its reaction rather than inferred from generic phosphoinositide involvement.
Reason: MTMR complexes interconvert phosphoinositides through dephosphorylation. The specific Reactome phosphatidylinositol biosynthesis placement should be traced to its reaction rather than inferred from generic phosphoinositide involvement.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0010507 negative regulation of autophagy
IBA
GO_REF:0000033
ACCEPT
Summary: negative regulation of autophagy: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
PMID:22647598
the MTMR8/R9 complex inhibits autophagy.
GO:0010507 negative regulation of autophagy
IPI
PMID:22647598
Myotubularin-related protein (MTMR) 9 determines the enzymat...
ACCEPT
Summary: negative regulation of autophagy: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
PMID:22647598
the MTMR8/R9 complex inhibits autophagy.
GO:0010922 positive regulation of phosphatase activity
IDA
PMID:22647598
Myotubularin-related protein (MTMR) 9 determines the enzymat...
ACCEPT
Summary: positive regulation of phosphatase activity: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
PMID:22647598
the MTMR8/R9 complex inhibits autophagy.
GO:0019211 phosphatase activator activity
EXP
PMID:19038970
MTMR9 increases MTMR6 enzyme activity, stability, and role i...
ACCEPT
Summary: phosphatase activator activity: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
PMID:22647598
the MTMR8/R9 complex inhibits autophagy.
GO:0019211 phosphatase activator activity
EXP
PMID:22647598
Myotubularin-related protein (MTMR) 9 determines the enzymat...
ACCEPT
Summary: phosphatase activator activity: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
PMID:22647598
the MTMR8/R9 complex inhibits autophagy.
GO:0019903 protein phosphatase binding
IBA
GO_REF:0000033
UNDECIDED
Summary: protein phosphatase binding: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity.
Reason: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0019903 protein phosphatase binding
IPI
PMID:16787938
Systematic analysis of myotubularins: heteromeric interactio...
UNDECIDED
Summary: protein phosphatase binding: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity.
Reason: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0019903 protein phosphatase binding
IPI
PMID:16787938
Systematic analysis of myotubularins: heteromeric interactio...
UNDECIDED
Summary: protein phosphatase binding: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity.
Reason: MTMR9 binds lipid phosphatases MTMR6/7/8, while the term specifically names protein phosphatase binding. The biological interaction is sound, but its fit to this partner-class term requires checking the ontology scope and the exact annotated binding partner; do not treat lipid phosphatase activity as conventional phosphoprotein activity.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0030234 enzyme regulator activity
IEA
GO_REF:0000120
MODIFY
Summary: enzyme regulator activity: Direct experiments show phosphatase activation, a more informative MF than generic enzyme regulator activity.
Reason: Direct experiments show phosphatase activation, a more informative MF than generic enzyme regulator activity.
Proposed replacements: phosphatase activator activity
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0032587 ruffle membrane
IEA
GO_REF:0000044
KEEP AS NON CORE
Summary: ruffle membrane: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function.
Reason: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function.
Supporting Evidence:
file:human/MTMR9/MTMR9-uniprot.txt
CC Partially localizes to the endoplasmic reticulum (PubMed:19038970).
GO:0032991 protein-containing complex
IDA
PMID:22647598
Myotubularin-related protein (MTMR) 9 determines the enzymat...
KEEP AS NON CORE
Summary: protein-containing complex: Complex formation is experimentally established, but this generic complex term is too broad to identify the MTMR6–MTMR9 or MTMR8–MTMR9 machinery.
Reason: Complex formation is experimentally established, but this generic complex term is too broad to identify the MTMR6–MTMR9 or MTMR8–MTMR9 machinery.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
GO:0046856 phosphatidylinositol dephosphorylation
IBA
GO_REF:0000033
ACCEPT
Summary: phosphatidylinositol dephosphorylation: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
PMID:22647598
the MTMR8/R9 complex inhibits autophagy.
GO:0048471 perinuclear region of cytoplasm
IEA
GO_REF:0000044
KEEP AS NON CORE
Summary: perinuclear region of cytoplasm: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function.
Reason: The curated localization evidence identifies ER/perinuclear or ruffle-associated pools. These sites qualify a mobile phosphoinositide-regulatory protein rather than defining a separate core molecular function.
Supporting Evidence:
file:human/MTMR9/MTMR9-uniprot.txt
CC Partially localizes to the endoplasmic reticulum (PubMed:19038970).
GO:0050821 protein stabilization
IDA
PMID:22647598
Myotubularin-related protein (MTMR) 9 determines the enzymat...
ACCEPT
Summary: protein stabilization: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
PMID:22647598
the MTMR8/R9 complex inhibits autophagy.
GO:0060304 regulation of phosphatidylinositol dephosphorylation
IDA
PMID:22647598
Myotubularin-related protein (MTMR) 9 determines the enzymat...
ACCEPT
Summary: regulation of phosphatidylinositol dephosphorylation: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Reason: Human MTMR9 forms complexes with active MTMR phosphatases and changes their activity, substrate preference and stability. Participation in phosphoinositide dephosphorylation and its regulation is supported despite MTMR9 itself being catalytically inactive. MTMR8–MTMR9 inhibits autophagy in cell experiments.
Supporting Evidence:
PMID:22647598
Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity
PMID:22647598
the MTMR8/R9 complex inhibits autophagy.

Core Functions

MTMR9 is a catalytically inactive myotubularin-family protein that binds active myotubularins and regulates their activity, substrate preference and stability.

Cellular Locations:
Supporting Evidence:
  • PMID:22647598
    Complex formation between the active myotubularins and MTMR9 increases their catalytic activity and alters their substrate specificity

References

Loading supporting content…

Download this section (compressed HTML)

Deep Research

Falcon

(MTMR9-deep-research-falcon.md)

Loading supporting content…

Download this section (compressed HTML)

πŸ“š Additional Documentation

Notes

(MTMR9-notes.md)

Loading supporting content…

Download this section (compressed HTML)

πŸ“„ View Raw YAML

Loading supporting content…

Download this section (compressed HTML)