NOTCH1 is a type I transmembrane receptor that functions as a master regulator of cell-fate determination through juxtacrine signaling. Upon binding membrane-bound ligands (JAG1/2, DLL1/4) on neighboring cells, NOTCH1 undergoes sequential proteolytic cleavages by furin (S1 in Golgi), ADAM10/17 (S2 at plasma membrane), and gamma-secretase (S3/S4), releasing the Notch Intracellular Domain (NICD). NICD translocates to the nucleus where it forms a transcriptional activation complex with RBPJ and MAML coactivators to drive expression of target genes including HES and HEY family members. NOTCH1 plays essential roles in T-cell development, angiogenesis, neurogenesis, heart development, and somitogenesis. Mutations cause T-cell acute lymphoblastic leukemia (activating) and aortic valve disease/Adams-Oliver syndrome (loss-of-function).
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0007219 Notch signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: NOTCH1 is the canonical receptor for the Notch signaling pathway. Upon ligand binding (JAG1/2, DLL1/3/4), NOTCH1 undergoes proteolytic cleavage releasing NICD which translocates to the nucleus to activate target genes via RBPJ/MAML complex. Reason: This is the core function of NOTCH1. The protein is THE defining receptor of the Notch signaling pathway, as documented extensively in UniProt and literature (Shi et al. 2024, doi:10.1038/s41392-024-01828-x). Supporting Evidence: PMID:10713164 Notch proteins are transmembrane receptors that mediate intercell communication and direct individual cell fate decisions. The activated intracellular form of Notch, NotchIC, translocates to the nucleus, where it targets the DNA binding protein CBF1. file:human/NOTCH1/NOTCH1-deep-research-cyberian.md model: deep-research |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: NOTCH1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells. Reason: Plasma membrane localization is essential for NOTCH1 receptor function. The mature NOTCH1 heterodimer traffics to and resides at the plasma membrane where it undergoes ligand-dependent activation. UniProt confirms cell membrane localization. Supporting Evidence: PMID:10713164 Notch proteins are transmembrane receptors that mediate intercell communication |
| GO:0007411 axon guidance | IBA GO_REF:0000033 | UNDECIDED | Summary: The SLIT-grounded source trace does not settle a biologically plausible Notch axon-guidance role. Reason: The PTN002911625 source is SLIT-grounded, but this does not disprove an independent NOTCH1 guidance mechanism. Primary Drosophila studies establish Notch/Disabled/Trio/Rac-dependent axon patterning, with cleavage and tyrosine requirements separable from cell-fate signaling (PMID:18062953, PMID:21246649, PMID:29343637). Mammalian studies establish neurite morphology and synaptic-protein effects (PMID:10465425, PMID:27040987), which neither directly demonstrate nor refute directional guidance. The focused OpenScientist report is incorporated, but its supposed fly/mouse Notch WITH/FROM donors are actually SLIT genes on verified identifiers, and its STRING absence is not a loss experiment. Human conservation and the correct ancestral basis remain unresolved; retain UNDECIDED rather than treating an unproven report recommendation as settled. Propagation Review Root cause: UNRESOLVED Sources checked: PANTHER:PTN002911625 · PTN002911625 UNRESOLVED The cached IBD and fresh QuickGO source trace remain SLIT-grounded. The focused report incorrectly names FBgn0264089 and MGI:1315202/1315203/1315205 as Notch genes; verified symbols are sli and Slit3/Slit1/Slit2. Independent fly Notch guidance experiments support biological plausibility, but human mechanism conservation remains unresolved. Supporting Evidence: PMID:18062953 Notch directs axon growth and guidance in Drosophila PMID:21246649 the Rac-specific GEF1, is essential for Trio-dependent motor axon guidance PMID:29343637 relevant tyrosines are essential for Notch-dependent axon patterning but not for canonical Notch-dependent regulation of cell fate. PMID:10465425 Transfection at two days in vitro with full length Notch1 inhibited neurite outgrowth. file:human/NOTCH1/NOTCH1-hypotheses/function-hypothesis-go-0007411/openscientist.md Sequence-level conservation of the specific fly guidance determinants was not aligned in this run |
| GO:0009986 cell surface | IBA GO_REF:0000033 | ACCEPT | Summary: NOTCH1 is expressed at the cell surface where it functions as a receptor for trans-acting ligands on neighboring cells. Reason: Cell surface localization is essential for NOTCH1 receptor function. The extracellular domain (N(EC)) binds ligands at the cell surface, triggering the proteolytic cascade. Supporting Evidence: PMID:10713164 Notch proteins are transmembrane receptors that mediate intercell communication |
| GO:0043235 receptor complex | IBA GO_REF:0000033 | ACCEPT | Summary: NOTCH1 exists as a heterodimeric receptor complex formed by furin cleavage during maturation. The N(EC) and N(TM) fragments remain associated at the cell surface. Reason: NOTCH1 forms a heterodimeric complex after S1 furin cleavage in the Golgi. The extracellular and transmembrane fragments are non-covalently associated. This is well-documented in UniProt and structural studies. |
| GO:0000139 Golgi membrane | IEA GO_REF:0000117 | ACCEPT | Summary: NOTCH1 undergoes S1 cleavage by furin in the trans-Golgi network during maturation, converting the precursor into the functional heterodimer. Reason: Golgi membrane localization is part of the NOTCH1 biosynthetic pathway. UniProt states the precursor is proteolytically cleaved by furin-like convertase in the trans-Golgi network before reaching the plasma membrane. |
| GO:0001525 angiogenesis | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: NOTCH1 plays a key role in angiogenesis by negatively regulating endothelial cell proliferation and migration. DLL4-NOTCH1 signaling controls tip/stalk cell selection during vascular development. Reason: While angiogenesis is a well-documented biological context for NOTCH1 function, it represents a tissue-specific outcome rather than the core molecular function. UniProt confirms NOTCH1 is involved in angiogenesis, negatively regulating endothelial cell proliferation. |
| GO:0005509 calcium ion binding | IEA GO_REF:0000002 | ACCEPT | Summary: NOTCH1 contains multiple EGF-like domains that bind calcium ions, which are essential for proper domain folding and ligand binding. Reason: Calcium binding is a core molecular function of NOTCH1. The EGF-like calcium-binding domains (IPR001881) are essential for NOTCH1 structure and function. UniProt lists calcium ion binding in the domain annotations. |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: The NOTCH1 intracellular domain (NICD) translocates to the nucleus following gamma-secretase cleavage to activate transcription. Reason: Nuclear localization of NICD is essential for NOTCH1 signaling. UniProt confirms NICD translocates to the nucleus following proteolytical processing. |
| GO:0005789 endoplasmic reticulum membrane | IEA GO_REF:0000117 | ACCEPT | Summary: NOTCH1 is synthesized and begins its maturation in the ER membrane before trafficking to the Golgi. Reason: ER membrane localization is part of the NOTCH1 biosynthetic pathway. UniProt notes synthesis in the endoplasmic reticulum as an inactive form. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: Mature NOTCH1 heterodimer resides at the plasma membrane where it functions as a receptor. Reason: Plasma membrane is the primary site of NOTCH1 receptor function. Duplicate of IBA annotation - both are correct. |
| GO:0006355 regulation of DNA-templated transcription | IEA GO_REF:0000002 | ACCEPT | Summary: NICD forms a transcriptional activation complex with RBPJ and MAML to regulate target gene expression. Reason: Transcriptional regulation is a core downstream function of NOTCH1 signaling. The NICD-RBPJ-MAML complex directly activates transcription of target genes like HES and HEY family members. |
| GO:0007219 Notch signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: NOTCH1 is the founding member and primary receptor of the Notch signaling pathway. Reason: Duplicate of IBA annotation - this is the core function of NOTCH1. Both evidence codes correctly annotate this term. |
| GO:0016020 membrane | IEA GO_REF:0000002 | ACCEPT | Summary: NOTCH1 is a type I transmembrane protein that localizes to various cellular membranes during its lifecycle. Reason: Generic membrane annotation is correct but less informative than more specific terms (plasma membrane, Golgi membrane, ER membrane) which are also annotated. |
| GO:0030154 cell differentiation | IEA GO_REF:0000120 | ACCEPT | Summary: NOTCH1 is a master regulator of cell-fate determination and differentiation across multiple tissue contexts. Reason: Cell differentiation regulation is a core biological role of NOTCH1 signaling. UniProt states NOTCH1 affects implementation of differentiation, proliferation and apoptotic programs. |
| GO:0031902 late endosome membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Non-activated NOTCH1 receptor is targeted for lysosomal degradation via the endosomal pathway. Reason: UniProt explicitly states late endosome membrane localization and notes that non-activated receptor is targeted for lysosomal degradation via the endosomal pathway. |
| GO:0038023 signaling receptor activity | IEA GO_REF:0000002 | ACCEPT | Summary: NOTCH1 functions as a signaling receptor that transduces cell-cell contact signals into transcriptional responses. Reason: Signaling receptor activity is a core molecular function of NOTCH1. This is the primary role of the protein. |
| GO:0045893 positive regulation of DNA-templated transcription | IEA GO_REF:0000117 | ACCEPT | Summary: NICD positively regulates transcription by forming a coactivator complex with RBPJ and MAML that displaces corepressors. Reason: NOTCH1 NICD functions as a transcriptional activator. The NICD-RBPJ-MAML complex recruits coactivators like p300 to activate target gene transcription. |
| GO:0046579 positive regulation of Ras protein signal transduction | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: NOTCH1 has been reported to crosstalk with Ras/MAPK signaling in certain cellular contexts. Reason: This represents crosstalk with other signaling pathways rather than the core NOTCH1 function. The canonical Notch pathway does not involve direct Ras activation, though downstream effects can influence Ras signaling. |
| GO:0046872 metal ion binding | IEA GO_REF:0000043 | ACCEPT | Summary: NOTCH1 binds calcium ions through its EGF-like domains. Reason: Metal ion binding (specifically calcium) is correct but less specific than GO:0005509 calcium ion binding which is also annotated. |
| GO:0050793 regulation of developmental process | IEA GO_REF:0000002 | ACCEPT | Summary: NOTCH1 is a key regulator of developmental processes including cell fate determination. Reason: Developmental regulation is a well-established function of NOTCH1. UniProt notes roles in postimplantation development, mesoderm development, somite formation, and neurogenesis. |
| GO:0051152 positive regulation of smooth muscle cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: NOTCH1 promotes vascular smooth muscle cell differentiation and is required for arterial smooth muscle development. Reason: Smooth muscle differentiation is a tissue-specific developmental outcome of NOTCH1 signaling rather than a core function. It represents one of many differentiation contexts where NOTCH1 plays a role. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: NOTCH1 can promote ERK1/2 signaling in certain cellular contexts, representing pathway crosstalk. Reason: ERK cascade regulation is not part of canonical Notch signaling but may occur through indirect mechanisms or crosstalk in specific contexts. |
| GO:0071228 cellular response to tumor cell | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: NOTCH1 has been implicated in tumor microenvironment responses. Reason: This is a specialized context-dependent role of NOTCH1 in cancer biology rather than a core function of the protein. |
| GO:0005515 protein binding | IPI PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin ... | REMOVE | Summary: NOTCH1 NICD interacts with SNW1/SKIP, which facilitates NOTCH1 transcriptional function by competing with SMRT corepressor. Reason: Generic protein binding is uninformative. The specific interaction with SNW1/SKIP should be captured by more specific MF terms or documented via protein-protein interaction databases. NOTCH1 has many specific binding partners including RBPJ, MAML1/2/3, ligands, etc. Supporting Evidence: PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |
| GO:0005515 protein binding | IPI PMID:12370315 Identification of a family of mastermind-like transcriptiona... | REMOVE | Summary: Identifies NOTCH1 interaction with MAML2 and MAML3 transcriptional coactivators. Reason: Generic protein binding is uninformative. The specific MAML interactions are critical for transcriptional activation but should not be annotated with this overly broad term. Supporting Evidence: PMID:12370315 Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. |
| GO:0005515 protein binding | IPI PMID:16319921 Notch1 augments NF-kappaB activity by facilitating its nucle... | REMOVE | Summary: NOTCH1 interaction with NF-kappaB to facilitate its nuclear retention. Reason: Generic protein binding is uninformative. This represents crosstalk with NF-kappaB signaling. Supporting Evidence: PMID:16319921 Notch1 augments NF-kappaB activity by facilitating its nuclear retention. |
| GO:0005515 protein binding | IPI PMID:16530044 Structural basis for cooperativity in recruitment of MAML co... | REMOVE | Summary: Structural basis for MAML coactivator recruitment to NOTCH transcription complexes - crystal structure of NICD-RBPJ-MAML1 complex. Reason: Generic protein binding is uninformative. The structural study documents the ternary transcription complex, which is better captured by specific complex annotations. Supporting Evidence: PMID:16530044 Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. |
| GO:0005515 protein binding | IPI PMID:17284587 Cooperative assembly of higher-order Notch complexes functio... | REMOVE | Summary: Studies cooperative assembly of higher-order Notch transcription complexes. Reason: Generic protein binding is uninformative. Documents transcription complex assembly dynamics. Supporting Evidence: PMID:17284587 Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. |
| GO:0005515 protein binding | IPI PMID:17318174 Notch inhibits apoptosis by direct interference with XIAP ub... | REMOVE | Summary: NOTCH1 interaction with XIAP to inhibit apoptosis. Reason: Generic protein binding is uninformative. The XIAP interaction represents a non-canonical NOTCH1 function. Supporting Evidence: PMID:17318174 Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation. |
| GO:0005515 protein binding | IPI PMID:17909182 Kaposi's sarcoma herpesvirus-encoded latency-associated nucl... | REMOVE | Summary: KSHV LANA stabilizes activated NOTCH by targeting FBXW7. Reason: Generic protein binding is uninformative. This is about viral protein interaction and NOTCH1 regulation. Supporting Evidence: PMID:17909182 Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein. |
| GO:0005515 protein binding | IPI PMID:18427106 Notch signaling mediates hypoxia-induced tumor cell migratio... | REMOVE | Summary: NOTCH1 signaling in hypoxia-induced tumor cell migration. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:18427106 Notch signaling mediates hypoxia-induced tumor cell migration and invasion. |
| GO:0005515 protein binding | IPI PMID:18660822 A conserved face of the Jagged/Serrate DSL domain is involve... | REMOVE | Summary: Jagged/Serrate DSL domain interaction with NOTCH for trans-activation and cis-inhibition. Reason: Generic protein binding is uninformative. Ligand-receptor interaction is critical for NOTCH1 function but should be captured by receptor activity terms. Supporting Evidence: PMID:18660822 Jul 27. A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. |
| GO:0005515 protein binding | IPI PMID:19151708 The prolyl-isomerase Pin1 is a Notch1 target that enhances N... | REMOVE | Summary: Pin1 prolyl isomerase interaction enhances NOTCH1 activation. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:19151708 The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer. |
| GO:0005515 protein binding | IPI PMID:19907488 Direct inhibition of the NOTCH transcription factor complex. | REMOVE | Summary: Direct inhibition of NOTCH transcription factor complex - stapled peptide SAHM1. Reason: Generic protein binding is uninformative. This is about therapeutic targeting. Supporting Evidence: PMID:19907488 Direct inhibition of the NOTCH transcription factor complex. |
| GO:0005515 protein binding | IPI PMID:20823234 Notch signaling contributes to proliferation and tumor forma... | REMOVE | Summary: NOTCH1 signaling in HTLV-1-associated adult T-cell leukemia. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:20823234 Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. |
| GO:0005515 protein binding | IPI PMID:20972443 Structural and mechanistic insights into cooperative assembl... | REMOVE | Summary: Cooperative assembly of dimeric NOTCH transcription complexes. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:20972443 Oct 24. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. |
| GO:0005515 protein binding | IPI PMID:21475249 Ataxin-1 and Brother of ataxin-1 are components of the Notch... | REMOVE | Summary: Ataxin-1 and BOAT are components of NOTCH signaling pathway. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:21475249 Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway. |
| GO:0005515 protein binding | IPI PMID:22325781 Conformational locking upon cooperative assembly of notch tr... | REMOVE | Summary: Conformational locking upon cooperative assembly of NOTCH transcription complexes. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:22325781 Conformational locking upon cooperative assembly of notch transcription complexes. |
| GO:0005515 protein binding | IPI PMID:23022380 NOTCH1 nuclear interactome reveals key regulators of its tra... | REMOVE | Summary: NOTCH1 nuclear interactome studies. Reason: Generic protein binding is uninformative. High-throughput interactome data. Supporting Evidence: PMID:23022380 2012 Sep 27. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. |
| GO:0005515 protein binding | IPI PMID:23086448 The CD46-Jagged1 interaction is critical for human TH1 immun... | REMOVE | Summary: CD46-Jagged1 interaction in TH1 immunity. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:23086448 The CD46-Jagged1 interaction is critical for human TH1 immunity. |
| GO:0005515 protein binding | IPI PMID:25344755 Cyclin C is a haploinsufficient tumour suppressor. | REMOVE | Summary: Cyclin C as tumor suppressor - interactions with NOTCH1. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:25344755 Cyclin C is a haploinsufficient tumour suppressor. |
| GO:0005515 protein binding | IPI PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and ... | REMOVE | Summary: Proteomic study of transcription factor complexes. Reason: Generic protein binding is uninformative. High-throughput data. Supporting Evidence: PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. |
| GO:0005515 protein binding | IPI PMID:25714926 Angiopoietin-like proteins stimulate HSPC development throug... | REMOVE | Summary: Angiopoietin-like proteins stimulate HSPC development through NOTCH receptor signaling. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:25714926 Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. |
| GO:0005515 protein binding | IPI PMID:25895060 Notch is a direct negative regulator of the DNA-damage respo... | REMOVE | Summary: NOTCH as negative regulator of DNA-damage response. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:25895060 Apr 20. Notch is a direct negative regulator of the DNA-damage response. |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | REMOVE | Summary: Human interactome in three quantitative dimensions - large-scale study. Reason: Generic protein binding is uninformative. High-throughput data. Supporting Evidence: PMID:26496610 Oct 22. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
| GO:0005515 protein binding | IPI PMID:27229929 Systematic interactome mapping of acute lymphoblastic leukem... | REMOVE | Summary: Systematic interactome mapping of ALL cancer gene products. Reason: Generic protein binding is uninformative. High-throughput data. Supporting Evidence: PMID:27229929 Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. |
| GO:0005515 protein binding | IPI PMID:33189893 A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Inte... | REMOVE | Summary: PAK1-NOTCH1 axis in crypt homeostasis during intestinal inflammation. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:33189893 A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Dual proteome-scale networks showing cell-specific remodeling of interactome. Reason: Generic protein binding is uninformative. High-throughput data. Supporting Evidence: PMID:33961781 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. |
| GO:0005515 protein binding | IPI PMID:38891776 Pin1 Downregulation Is Involved in Excess Retinoic Acid-Indu... | REMOVE | Summary: Pin1 downregulation in retinoic acid-induced neural tube closure failure. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:38891776 Pin1 Downregulation Is Involved in Excess Retinoic Acid-Induced Failure of Neural Tube Closure. |
| GO:0042802 identical protein binding | IPI PMID:16738328 Leukemia-associated mutations within the NOTCH1 heterodimeri... | ACCEPT | Summary: NOTCH1 can form homodimers through its heterodimerization domain. Mutations in this domain cause T-ALL. Reason: NOTCH1 homodimerization is documented and has functional significance. The study shows leukemia-associated mutations fall into distinct mechanistic classes affecting the HD domain. Supporting Evidence: PMID:16738328 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 can negatively regulate certain genes through target gene specificity and crosstalk with repressive mechanisms. Reason: While NOTCH1 primarily activates transcription, it can also lead to repression of certain targets depending on context. This is a secondary regulatory outcome. |
| GO:0001554 luteolysis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH signaling has been implicated in ovarian function including corpus luteum regression. Reason: Luteolysis is a highly specialized reproductive process. NOTCH1 may play a role but this is tissue-specific rather than a core function. |
| GO:0001669 acrosomal vesicle | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 may be present in acrosomal vesicles during spermatogenesis. Reason: This is a specialized spermatogenesis-related localization. NOTCH1 has roles in germ cell development but this is not a core localization. |
| GO:0001947 heart looping | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is required for proper cardiac morphogenesis including heart looping during development. Reason: Heart looping is a specific developmental process. NOTCH1 mutations cause congenital heart defects (AOVD1), confirming cardiac development roles, but this is tissue-specific. |
| GO:0002052 positive regulation of neuroblast proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 promotes neural progenitor/stem cell proliferation and maintains the undifferentiated state. Reason: NOTCH1 maintains neural stem cells and regulates neurogenesis, but this is a tissue-specific developmental function. |
| GO:0003157 endocardium development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is essential for endocardium development and endocardial cell differentiation. Reason: Cardiac development is a well-established NOTCH1 function based on human disease genetics (AOVD1, AOS5), but represents tissue-specific developmental role. |
| GO:0003160 endocardium morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates endocardium morphogenesis during heart development. Reason: Related to cardiac development - tissue-specific developmental function. |
| GO:0003162 atrioventricular node development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in development of cardiac conduction system components. Reason: Specialized cardiac developmental process. |
| GO:0003169 coronary vein morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates coronary vessel development including vein morphogenesis. Reason: Cardiac/vascular development - tissue-specific developmental function. |
| GO:0003180 aortic valve morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is essential for aortic valve development. NOTCH1 mutations cause aortic valve disease (AOVD1). Reason: Strongly supported by human genetics - NOTCH1 mutations cause bicuspid aortic valve and calcific aortic valve disease (OMIM:109730). This is a key developmental phenotype but tissue-specific. |
| GO:0003181 atrioventricular valve morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates AV valve development through endocardial cushion formation. Reason: Cardiac valve development - tissue-specific developmental function supported by mouse studies. |
| GO:0003182 coronary sinus valve morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates coronary sinus valve development. Reason: Highly specialized cardiac structure - tissue-specific developmental function. |
| GO:0003184 pulmonary valve morphogenesis | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: NOTCH1 regulates pulmonary valve development. Human NOTCH1 mutations cause pulmonary valve abnormalities. Reason: Cardiac valve development - tissue-specific developmental function supported by human genetics. |
| GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 promotes EMT during endocardial cushion formation, essential for valve development. Reason: EMT in heart development is well-documented for NOTCH1. Tissue-specific developmental function. |
| GO:0003203 endocardial cushion morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is required for endocardial cushion development which gives rise to heart valves. Reason: Cardiac development - tissue-specific function. |
| GO:0003207 cardiac chamber formation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac chamber formation during heart development. Reason: Cardiac development - tissue-specific function. |
| GO:0003208 cardiac ventricle morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates ventricular development. Reason: Cardiac development - tissue-specific function. |
| GO:0003209 cardiac atrium morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates atrial development. Reason: Cardiac development - tissue-specific function. |
| GO:0003213 cardiac right atrium morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates right atrium morphogenesis. Reason: Cardiac development - tissue-specific function. |
| GO:0003214 cardiac left ventricle morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates left ventricle morphogenesis. Relevant to hypoplastic left heart syndrome. Reason: Cardiac development - tissue-specific function. |
| GO:0003222 ventricular trabecula myocardium morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates trabeculation of the ventricular myocardium. Reason: Cardiac development - tissue-specific function. |
| GO:0003241 growth involved in heart morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates growth during cardiac morphogenesis. Reason: Cardiac development - tissue-specific function. |
| GO:0003252 obsolete negative regulation of cell proliferation involved in heart valve morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 negatively regulates cell proliferation during valve morphogenesis. Reason: Cardiac valve development - tissue-specific function. |
| GO:0003264 regulation of cardioblast proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardioblast proliferation during heart development. Reason: Cardiac development - tissue-specific function. |
| GO:0003273 cell migration involved in endocardial cushion formation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates cell migration during endocardial cushion formation. Reason: Cardiac development - tissue-specific function. |
| GO:0003332 negative regulation of extracellular matrix constituent secretion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 negatively regulates ECM secretion in certain contexts. Reason: Context-dependent regulatory function. |
| GO:0003344 pericardium morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates pericardium development. Reason: Cardiac development - tissue-specific function. |
| GO:0003682 chromatin binding | IEA GO_REF:0000107 | ACCEPT | Summary: NICD associates with chromatin as part of the transcription activation complex with RBPJ. Reason: NICD binds to chromatin at target gene promoters as part of the RBPJ-MAML transcription complex. This is part of the core transcriptional mechanism. |
| GO:0003713 transcription coactivator activity | IEA GO_REF:0000107 | ACCEPT | Summary: NICD functions as a transcriptional coactivator by converting RBPJ from a repressor to an activator. Reason: Transcription coactivator activity is a core molecular function of NICD. It recruits MAML and displaces corepressors from RBPJ. |
| GO:0004857 enzyme inhibitor activity | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Notch ankyrin repeats can competitively inhibit FIH-dependent HIF hydroxylation. Reason: PMID:17573339 experimentally shows Notch ankyrin-repeat substrates competing with HIF for FIH/HIF1AN and proposes their natural inhibitor function; PMID:18299578 further supports Notch-FIH sequestration and hypoxia-pathway cross-talk. The transferred enzyme-inhibitor function therefore has a mechanistic basis, but its physiological importance is context dependent and separate from canonical Notch signaling. Supporting Evidence: PMID:17573339 ARD proteins were found to efficiently compete with HIF for FIH-dependent hydroxylation. |
| GO:0004888 transmembrane signaling receptor activity | IEA GO_REF:0000107 | ACCEPT | Summary: NOTCH1 is a transmembrane receptor that transduces signals from cell-cell contact to transcriptional responses. Reason: This is the core molecular function of NOTCH1. It is a type I transmembrane receptor that signals via proteolytic processing. |
| GO:0005112 Notch binding | IEA GO_REF:0000107 | ACCEPT | Summary: NOTCH1 can bind other NOTCH family members, potentially in cis-inhibition or heterodimer formation. Reason: NOTCH receptors can interact with each other. The identical protein binding annotation (GO:0042802) already captures homodimerization. |
| GO:0005737 cytoplasm | IEA GO_REF:0000107 | ACCEPT | Summary: Cytoplasm Reason: NICD transits through cytoplasm. |
| GO:0005783 endoplasmic reticulum | IEA GO_REF:0000107 | ACCEPT | Summary: Endoplasmic reticulum Reason: NOTCH1 synthesis and maturation. |
| GO:0005912 adherens junction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to adherens junction. Reason: Transferred annotation - context-specific function. |
| GO:0006606 protein import into nucleus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to protein import into nucleus. Reason: Transferred annotation - context-specific function. |
| GO:0007221 positive regulation of transcription of Notch receptor target | IEA GO_REF:0000107 | ACCEPT | Summary: Positive regulation of transcription of Notch receptor target Reason: Core downstream function of NICD. |
| GO:0007283 spermatogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to spermatogenesis. Reason: Transferred annotation - context-specific function. |
| GO:0009986 cell surface | IEA GO_REF:0000107 | ACCEPT | Summary: Cell surface Reason: NOTCH1 receptor functions at cell surface. |
| GO:0010467 gene expression | IEA GO_REF:0000107 | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. |
| GO:0010614 negative regulation of cardiac muscle hypertrophy | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates negative regulation of cardiac muscle hypertrophy. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0010628 positive regulation of gene expression | IEA GO_REF:0000120 | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. |
| GO:0010667 negative regulation of cardiac muscle cell apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates negative regulation of cardiac muscle cell apoptotic process. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0010718 positive regulation of epithelial to mesenchymal transition | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 promotes positive regulation of epithelial to mesenchymal transition. Reason: EMT regulation - context-dependent function. |
| GO:0010832 negative regulation of myotube differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of myotube differentiation. Reason: Context-dependent regulatory function. |
| GO:0014031 mesenchymal cell development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 promotes mesenchymal cell development. Reason: EMT regulation - context-dependent function. |
| GO:0016324 apical plasma membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to apical plasma membrane. Reason: Transferred annotation - context-specific function. |
| GO:0019899 enzyme binding | IEA GO_REF:0000107 | ACCEPT | Summary: Enzyme binding Reason: NOTCH1 binds enzymes involved in its processing. |
| GO:0021515 cell differentiation in spinal cord | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in cell differentiation in spinal cord. Reason: Neural development - tissue-specific function. |
| GO:0030163 protein catabolic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to protein catabolic process. Reason: Transferred annotation - context-specific function. |
| GO:0030279 negative regulation of ossification | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of ossification. Reason: Context-dependent regulatory function. |
| GO:0030334 regulation of cell migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to regulation of cell migration. Reason: Transferred annotation - context-specific function. |
| GO:0030335 positive regulation of cell migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of cell migration. Reason: Context-dependent regulatory function. |
| GO:0030513 positive regulation of BMP signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of bmp signaling pathway. Reason: Context-dependent regulatory function. |
| GO:0030514 negative regulation of BMP signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of bmp signaling pathway. Reason: Context-dependent regulatory function. |
| GO:0031100 animal organ regeneration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to animal organ regeneration. Reason: Transferred annotation - context-specific function. |
| GO:0031410 cytoplasmic vesicle | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to cytoplasmic vesicle. Reason: Transferred annotation - context-specific function. |
| GO:0031490 chromatin DNA binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to chromatin DNA binding. Reason: Transferred annotation - context-specific function. |
| GO:0032495 response to muramyl dipeptide | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in response to muramyl dipeptide. Reason: Context-dependent regulatory function. |
| GO:0032496 response to lipopolysaccharide | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in response to lipopolysaccharide. Reason: Context-dependent regulatory function. |
| GO:0032966 negative regulation of collagen biosynthetic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of collagen biosynthetic process. Reason: Context-dependent regulatory function. |
| GO:0042127 regulation of cell population proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to regulation of cell population proliferation. Reason: Transferred annotation - context-specific function. |
| GO:0042246 tissue regeneration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to tissue regeneration. Reason: Transferred annotation - context-specific function. |
| GO:0045070 positive regulation of viral genome replication | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of viral genome replication. Reason: Context-dependent regulatory function. |
| GO:0045603 positive regulation of endothelial cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates positive regulation of endothelial cell differentiation. Reason: Vascular development - tissue-specific function. |
| GO:0045665 negative regulation of neuron differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: NOTCH1 is involved in negative regulation of neuron differentiation via Notch-mediated lateral inhibition, a canonical function in the neuron-glia binary fate decision. Reason: Core developmental function - NOTCH1-mediated lateral inhibition is the canonical mechanism controlling neuron-glia fate choice. PMID:12052917, PMID:11182080. |
| GO:0045668 negative regulation of osteoblast differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of osteoblast differentiation. Reason: Context-dependent regulatory function. |
| GO:0045687 positive regulation of glial cell differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: NOTCH1 promotes glial cell differentiation via lateral inhibition, instructing multipotent progenitors toward glial fate. Reason: Core developmental function - NOTCH1 instructs neural progenitors toward glial fate as part of the neuron-glia binary decision. PMID:11182080, PMID:23307615. |
| GO:0045892 negative regulation of DNA-templated transcription | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of dna-templated transcription. Reason: Context-dependent regulatory function. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of receptor signaling pathway via jak-stat. Reason: Context-dependent regulatory function. |
| GO:0048708 astrocyte differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: NOTCH1 promotes astrocyte differentiation as part of gliogenesis, with Sox9 acting as critical downstream mediator. Reason: Core gliogenic function - NOTCH1 signaling promotes astrocyte fate via HES/HEY factors. PMID:23307615, PMID:11182080. |
| GO:0048709 oligodendrocyte differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: NOTCH1 regulates oligodendrocyte differentiation (inhibitory role - promotes astrocyte over oligodendrocyte fate). Reason: Core gliogenic function - NOTCH1 inhibits oligodendrocyte fate, promoting astrocyte fate within the glial lineage. PMID:11182080. |
| GO:0048711 positive regulation of astrocyte differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: NOTCH1 positively regulates astrocyte differentiation via HES/HEY transcriptional targets. Reason: Core gliogenic function - canonical Notch target genes promote astrocyte gene expression. PMID:11182080, PMID:23307615. |
| GO:0048715 negative regulation of oligodendrocyte differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: NOTCH1 negatively regulates oligodendrocyte differentiation, favoring astrocyte fate. Reason: Core gliogenic function - NOTCH1 promotes astrocyte over oligodendrocyte fate in glial progenitors. PMID:11182080. |
| GO:0048873 homeostasis of number of cells within a tissue | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to homeostasis of number of cells within a tissue. Reason: Transferred annotation - context-specific function. |
| GO:0050768 negative regulation of neurogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of neurogenesis. Reason: Neural development - tissue-specific function. |
| GO:0055008 cardiac muscle tissue morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac muscle tissue morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060038 cardiac muscle cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac muscle cell proliferation. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060045 positive regulation of cardiac muscle cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates positive regulation of cardiac muscle cell proliferation. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060253 negative regulation of glial cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of glial cell proliferation. Reason: Context-dependent regulatory function. |
| GO:0060317 cardiac epithelial to mesenchymal transition | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac epithelial to mesenchymal transition. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060379 cardiac muscle cell myoblast differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac muscle cell myoblast differentiation. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060411 cardiac septum morphogenesis | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac septum morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060412 ventricular septum morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to ventricular septum morphogenesis. Reason: Transferred annotation - context-specific function. |
| GO:0060842 arterial endothelial cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates arterial endothelial cell differentiation. Reason: Vascular development - tissue-specific function. |
| GO:0060843 venous endothelial cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates venous endothelial cell differentiation. Reason: Vascular development - tissue-specific function. |
| GO:0060948 cardiac vascular smooth muscle cell development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac vascular smooth muscle cell development. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060956 endocardial cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to endocardial cell differentiation. Reason: Transferred annotation - context-specific function. |
| GO:0060979 vasculogenesis involved in coronary vascular morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates vasculogenesis involved in coronary vascular morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060982 coronary artery morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates coronary artery morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0061344 regulation of cell adhesion involved in heart morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates regulation of cell adhesion involved in heart morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0061384 heart trabecula morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates heart trabecula morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0062043 positive regulation of cardiac epithelial to mesenchymal transition | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates positive regulation of cardiac epithelial to mesenchymal transition. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0070168 negative regulation of biomineral tissue development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of biomineral tissue development. Reason: Context-dependent regulatory function. |
| GO:0070986 left/right axis specification | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to left/right axis specification. Reason: Transferred annotation - context-specific function. |
| GO:0071456 cellular response to hypoxia | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in cellular response to hypoxia. Reason: Context-dependent regulatory function. |
| GO:0071944 cell periphery | IEA GO_REF:0000107 | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: Cell periphery includes the plasma membrane, where mature NOTCH1 receives its ligands. The parent location is compatible with a core receptor function. |
| GO:0072017 distal tubule development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to distal tubule development. Reason: Transferred annotation - context-specific function. |
| GO:0072044 collecting duct development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to collecting duct development. Reason: Transferred annotation - context-specific function. |
| GO:0072144 glomerular mesangial cell development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to glomerular mesangial cell development. Reason: Transferred annotation - context-specific function. |
| GO:0072538 T-helper 17 type immune response | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 regulates t-helper 17 type immune response. Reason: T cell/immune development - tissue-specific function. |
| GO:0097400 interleukin-17-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to interleukin-17-mediated signaling pathway. Reason: Transferred annotation - context-specific function. |
| GO:0098685 Schaffer collateral - CA1 synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to Schaffer collateral - CA1 synapse. Reason: Transferred annotation - context-specific function. |
| GO:0098839 postsynaptic density membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to postsynaptic density membrane. Reason: Transferred annotation - context-specific function. |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to glutamatergic synapse. Reason: Transferred annotation - context-specific function. |
| GO:0099565 chemical synaptic transmission, postsynaptic | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to chemical synaptic transmission, postsynaptic. Reason: Transferred annotation - context-specific function. |
| GO:0120163 negative regulation of cold-induced thermogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of cold-induced thermogenesis. Reason: Context-dependent regulatory function. |
| GO:0140537 transcription regulator activator activity | IEA GO_REF:0000107 | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. |
| GO:1901201 regulation of extracellular matrix assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 annotation to regulation of extracellular matrix assembly. Reason: Transferred annotation - context-specific function. |
| GO:1902339 positive regulation of apoptotic process involved in morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of apoptotic process involved in morphogenesis. Reason: Context-dependent regulatory function. |
| GO:2000974 negative regulation of pro-B cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of pro-b cell differentiation. Reason: Context-dependent regulatory function. |
| GO:0005515 protein binding | IPI PMID:38016980 TM2D3, a mammalian homologue of Drosophila neurogenic gene p... | REMOVE | Summary: Generic protein binding annotation. Reason: Generic protein binding is uninformative. Specific interactions should be captured by more specific terms. Supporting Evidence: PMID:38016980 TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2220978 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005634 nucleus | IDA PMID:32601208 Pharmacological disruption of the Notch transcription factor... | ACCEPT | Summary: Nucleus Reason: NICD translocates to nucleus. Supporting Evidence: PMID:32601208 Pharmacological disruption of the Notch transcription factor complex. |
| GO:0007219 Notch signaling pathway | IDA PMID:32601208 Pharmacological disruption of the Notch transcription factor... | ACCEPT | Summary: Notch signaling pathway Reason: Core function - NOTCH1 IS the pathway receptor. Supporting Evidence: PMID:32601208 Pharmacological disruption of the Notch transcription factor complex. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:32601208 Pharmacological disruption of the Notch transcription factor... | ACCEPT | Summary: Positive regulation of DNA-templated transcription Reason: NICD activates transcription. Supporting Evidence: PMID:32601208 Pharmacological disruption of the Notch transcription factor complex. |
| GO:0003713 transcription coactivator activity | IDA PMID:18239137 Hairy-related transcription factors inhibit Notch-induced sm... | ACCEPT | Summary: Transcription coactivator activity Reason: NICD functions as transcriptional coactivator with RBPJ-MAML. Supporting Evidence: PMID:18239137 2008 Jan 31. Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:18239137 Hairy-related transcription factors inhibit Notch-induced sm... | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. Supporting Evidence: PMID:18239137 2008 Jan 31. Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. |
| GO:0051152 positive regulation of smooth muscle cell differentiation | IDA PMID:18239137 Hairy-related transcription factors inhibit Notch-induced sm... | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of smooth muscle cell differentiation. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:18239137 2008 Jan 31. Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. |
| GO:0007219 Notch signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: Notch signaling pathway Reason: Core function - NOTCH1 IS the pathway receptor. |
| GO:0007219 Notch signaling pathway | IMP PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. | ACCEPT | Summary: Notch signaling pathway Reason: Core function - NOTCH1 IS the pathway receptor. Supporting Evidence: PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
| GO:0007219 Notch signaling pathway | IMP PMID:17662764 Novel NOTCH1 mutations in patients with bicuspid aortic valv... | ACCEPT | Summary: Notch signaling pathway Reason: Core function - NOTCH1 IS the pathway receptor. Supporting Evidence: PMID:17662764 Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2660815 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2660816 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2660819 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2660822 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2666278 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2220957 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2220964 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2220967 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2220971 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2220982 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2769015 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4396392 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4396393 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4396401 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4396402 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2220988 | ACCEPT | Summary: Cytosol Reason: NICD released to cytosol before nuclear import. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2769015 | ACCEPT | Summary: Cytosol Reason: NICD released to cytosol before nuclear import. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2220944 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2220976 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2220988 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2768993 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2768999 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2769000 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2769007 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2769008 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2900743 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2900747 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2900748 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2900756 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2900765 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0003713 transcription coactivator activity | IDA PMID:23839946 Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta... | ACCEPT | Summary: Transcription coactivator activity Reason: NICD functions as transcriptional coactivator with RBPJ-MAML. Supporting Evidence: PMID:23839946 Epub 2013 Jul 9. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. |
| GO:0004888 transmembrane signaling receptor activity | IDA PMID:23839946 Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta... | ACCEPT | Summary: Transmembrane signaling receptor activity Reason: Core molecular function of NOTCH1. Supporting Evidence: PMID:23839946 Epub 2013 Jul 9. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. |
| GO:0005515 protein binding | IPI PMID:23839946 Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta... | REMOVE | Summary: Generic protein binding annotation. Reason: Generic protein binding is uninformative. Specific interactions should be captured by more specific terms. Supporting Evidence: PMID:23839946 Epub 2013 Jul 9. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. |
| GO:0007219 Notch signaling pathway | IDA PMID:23839946 Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta... | ACCEPT | Summary: Notch signaling pathway Reason: Core function - NOTCH1 IS the pathway receptor. Supporting Evidence: PMID:23839946 Epub 2013 Jul 9. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:23839946 Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta... | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. Supporting Evidence: PMID:23839946 Epub 2013 Jul 9. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. |
| GO:0010008 endosome membrane | TAS Reactome:R-HSA-9796071 | ACCEPT | Summary: Endosome membrane Reason: NOTCH1 trafficking. |
| GO:0050768 negative regulation of neurogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of neurogenesis. Reason: Neural development - tissue-specific function. |
| GO:0071456 cellular response to hypoxia | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in cellular response to hypoxia. Reason: Context-dependent regulatory function. |
| GO:0006357 regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. |
| GO:0060379 cardiac muscle cell myoblast differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac muscle cell myoblast differentiation. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2220976 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2900743 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2900747 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2900748 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2900756 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2900765 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0007219 Notch signaling pathway | IDA PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung... | ACCEPT | Summary: Notch signaling pathway Reason: Core function - NOTCH1 IS the pathway receptor. Supporting Evidence: PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung cancer cells. |
| GO:0010629 negative regulation of gene expression | IDA PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of gene expression. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung cancer cells. |
| GO:0046579 positive regulation of Ras protein signal transduction | IDA PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung... | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of ras protein signal transduction. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung cancer cells. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IDA PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung... | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of erk1 and erk2 cascade. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung cancer cells. |
| GO:0071228 cellular response to tumor cell | IDA PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung... | KEEP AS NON CORE | Summary: NOTCH1 is involved in cellular response to tumor cell. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:11306509 Notch signaling induces cell cycle arrest in small cell lung cancer cells. |
| GO:0003713 transcription coactivator activity | ISS GO_REF:0000024 | ACCEPT | Summary: Transcription coactivator activity Reason: NICD functions as transcriptional coactivator with RBPJ-MAML. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IMP PMID:17984306 Jagged1-mediated Notch activation induces epithelial-to-mese... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of transcription by rna polymerase ii. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:17984306 Nov 5. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. |
| GO:0001837 epithelial to mesenchymal transition | IMP PMID:17984306 Jagged1-mediated Notch activation induces epithelial-to-mese... | KEEP AS NON CORE | Summary: NOTCH1 promotes epithelial to mesenchymal transition. Reason: EMT regulation - context-dependent function. Supporting Evidence: PMID:17984306 Nov 5. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. |
| GO:0060354 negative regulation of cell adhesion molecule production | IMP PMID:17984306 Jagged1-mediated Notch activation induces epithelial-to-mese... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of cell adhesion molecule production. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:17984306 Nov 5. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. |
| GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin | IMP PMID:17984306 Jagged1-mediated Notch activation induces epithelial-to-mese... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of cell-cell adhesion mediated by cadherin. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:17984306 Nov 5. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. |
| GO:2000811 negative regulation of anoikis | IMP PMID:17984306 Jagged1-mediated Notch activation induces epithelial-to-mese... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of anoikis. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:17984306 Nov 5. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. |
| GO:0003180 aortic valve morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates aortic valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003184 pulmonary valve morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates pulmonary valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003203 endocardial cushion morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 annotation to endocardial cushion morphogenesis. Reason: Transferred annotation - context-specific function. |
| GO:0048873 homeostasis of number of cells within a tissue | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 annotation to homeostasis of number of cells within a tissue. Reason: Transferred annotation - context-specific function. |
| GO:0070168 negative regulation of biomineral tissue development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of biomineral tissue development. Reason: Context-dependent regulatory function. |
| GO:0120163 negative regulation of cold-induced thermogenesis | ISS PMID:25038826 Inhibition of Notch signaling promotes browning of white adi... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of cold-induced thermogenesis. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:25038826 Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. |
| GO:0062043 positive regulation of cardiac epithelial to mesenchymal transition | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates positive regulation of cardiac epithelial to mesenchymal transition. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003252 obsolete negative regulation of cell proliferation involved in heart valve morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates negative regulation of cell proliferation involved in heart valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003332 negative regulation of extracellular matrix constituent secretion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of extracellular matrix constituent secretion. Reason: Context-dependent regulatory function. |
| GO:0010614 negative regulation of cardiac muscle hypertrophy | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates negative regulation of cardiac muscle hypertrophy. Reason: Cardiac development - tissue-specific developmental function. |
| GO:1902339 positive regulation of apoptotic process involved in morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of apoptotic process involved in morphogenesis. Reason: Context-dependent regulatory function. |
| GO:0005634 nucleus | ISS GO_REF:0000024 | ACCEPT | Summary: Nucleus Reason: NICD translocates to nucleus. |
| GO:0010628 positive regulation of gene expression | ISS GO_REF:0000024 | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. |
| GO:0003151 outflow tract morphogenesis | IMP PMID:18593716 NOTCH1 mutations in individuals with left ventricular outflo... | KEEP AS NON CORE | Summary: NOTCH1 annotation to outflow tract morphogenesis. Reason: Transferred annotation - context-specific function. Supporting Evidence: PMID:18593716 Jun 30. NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. |
| GO:0003180 aortic valve morphogenesis | TAS PMID:20951801 NOTCH1 missense alleles associated with left ventricular out... | KEEP AS NON CORE | Summary: NOTCH1 regulates aortic valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. Supporting Evidence: PMID:20951801 NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. |
| GO:0005886 plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0003180 aortic valve morphogenesis | IMP PMID:18593716 NOTCH1 mutations in individuals with left ventricular outflo... | KEEP AS NON CORE | Summary: NOTCH1 regulates aortic valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. Supporting Evidence: PMID:18593716 Jun 30. NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. |
| GO:0005515 protein binding | IPI PMID:25038227 NACK is an integral component of the Notch transcriptional a... | REMOVE | Summary: Generic protein binding annotation. Reason: Generic protein binding is uninformative. Specific interactions should be captured by more specific terms. Supporting Evidence: PMID:25038227 Epub 2014 Jul 18. NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. |
| GO:0005912 adherens junction | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 annotation to adherens junction. Reason: Transferred annotation - context-specific function. |
| GO:0016324 apical plasma membrane | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 annotation to apical plasma membrane. Reason: Transferred annotation - context-specific function. |
| GO:0005515 protein binding | IPI PMID:11006133 Physical interaction of Delta1, Jagged1, and Jagged2 with No... | REMOVE | Summary: Generic protein binding annotation. Reason: Generic protein binding is uninformative. Specific interactions should be captured by more specific terms. Supporting Evidence: PMID:11006133 Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. |
| GO:0043235 receptor complex | IDA PMID:23382219 Structural basis for endosomal trafficking of diverse transm... | ACCEPT | Summary: Receptor complex Reason: NOTCH1 forms heterodimeric complex. Supporting Evidence: PMID:23382219 Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. |
| GO:0060271 cilium assembly | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 annotation to cilium assembly. Reason: Transferred annotation - context-specific function. |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-1912412 | ACCEPT | Summary: ER membrane Reason: NOTCH1 biosynthesis in ER. |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-1912369 | ACCEPT | Summary: Golgi membrane Reason: S1 furin cleavage occurs in Golgi. |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-1912382 | ACCEPT | Summary: Golgi membrane Reason: S1 furin cleavage occurs in Golgi. |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-5096538 | ACCEPT | Summary: Golgi membrane Reason: S1 furin cleavage occurs in Golgi. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1912382 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1980044 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1980122 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2220944 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2691211 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2691214 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2691219 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2691226 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2730752 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2737728 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2768993 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2768999 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2769000 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2769007 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2769008 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0005576 extracellular region | TAS Reactome:R-NUL-2076711 | KEEP AS NON CORE | Summary: NOTCH1 annotation to extracellular region. Reason: Transferred annotation - context-specific function. |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-1912372 | ACCEPT | Summary: Golgi membrane Reason: S1 furin cleavage occurs in Golgi. |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-1912379 | ACCEPT | Summary: Golgi membrane Reason: S1 furin cleavage occurs in Golgi. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-1912394 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-212356 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4396371 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4396379 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8878220 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8878237 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9017835 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9021451 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9762102 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005654 nucleoplasm | TAS Reactome:R-NUL-2064264 | ACCEPT | Summary: Nucleoplasm Reason: NICD functions in nucleoplasm for transcription. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1912379 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1912382 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1980044 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1980122 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2660815 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2660816 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2660819 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2660822 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2666278 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2691211 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2691214 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2691219 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2691226 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2730752 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2737728 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-2076711 | ACCEPT | Summary: Plasma membrane Reason: Primary site of NOTCH1 receptor function. |
| GO:0008285 negative regulation of cell population proliferation | IDA PMID:20616313 Integrin cytoplasmic domain-associated protein-1 attenuates ... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of cell population proliferation. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:20616313 2010 Jul 8. Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. |
| GO:0035148 tube formation | IMP PMID:20616313 Integrin cytoplasmic domain-associated protein-1 attenuates ... | KEEP AS NON CORE | Summary: NOTCH1 annotation to tube formation. Reason: Transferred annotation - context-specific function. Supporting Evidence: PMID:20616313 2010 Jul 8. Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. |
| GO:0035924 cellular response to vascular endothelial growth factor stimulus | IDA PMID:20616313 Integrin cytoplasmic domain-associated protein-1 attenuates ... | KEEP AS NON CORE | Summary: NOTCH1 regulates cellular response to vascular endothelial growth factor stimulus. Reason: Vascular development - tissue-specific function. Supporting Evidence: PMID:20616313 2010 Jul 8. Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:20616313 Integrin cytoplasmic domain-associated protein-1 attenuates ... | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. Supporting Evidence: PMID:20616313 2010 Jul 8. Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. |
| GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis | IDA PMID:20616313 Integrin cytoplasmic domain-associated protein-1 attenuates ... | KEEP AS NON CORE | Summary: NOTCH1 regulates negative regulation of cell migration involved in sprouting angiogenesis. Reason: Vascular development - tissue-specific function. Supporting Evidence: PMID:20616313 2010 Jul 8. Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. |
| GO:2001027 negative regulation of endothelial cell chemotaxis | IDA PMID:20616313 Integrin cytoplasmic domain-associated protein-1 attenuates ... | KEEP AS NON CORE | Summary: NOTCH1 regulates negative regulation of endothelial cell chemotaxis. Reason: Vascular development - tissue-specific function. Supporting Evidence: PMID:20616313 2010 Jul 8. Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. |
| GO:0003273 cell migration involved in endocardial cushion formation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in cell migration involved in endocardial cushion formation. Reason: Context-dependent regulatory function. |
| GO:0007368 determination of left/right symmetry | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 annotation to determination of left/right symmetry. Reason: Transferred annotation - context-specific function. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:20613903 Follicular stimulating hormone enhances Notch 1 expression i... | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of cell population proliferation. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:20613903 2010 Jun 30. Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells. |
| GO:0071372 cellular response to follicle-stimulating hormone stimulus | IDA PMID:20613903 Follicular stimulating hormone enhances Notch 1 expression i... | KEEP AS NON CORE | Summary: NOTCH1 is involved in cellular response to follicle-stimulating hormone stimulus. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:20613903 2010 Jun 30. Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells. |
| GO:0003184 pulmonary valve morphogenesis | IMP PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. | KEEP AS NON CORE | Summary: NOTCH1 regulates pulmonary valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. Supporting Evidence: PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
| GO:0003192 mitral valve formation | IMP PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. | KEEP AS NON CORE | Summary: NOTCH1 regulates mitral valve formation. Reason: Cardiac development - tissue-specific developmental function. Supporting Evidence: PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
| GO:0060412 ventricular septum morphogenesis | IMP PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. | KEEP AS NON CORE | Summary: NOTCH1 annotation to ventricular septum morphogenesis. Reason: Transferred annotation - context-specific function. Supporting Evidence: PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
| GO:0001837 epithelial to mesenchymal transition | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 promotes epithelial to mesenchymal transition. Reason: EMT regulation - context-dependent function. |
| GO:0003180 aortic valve morphogenesis | IMP PMID:17662764 Novel NOTCH1 mutations in patients with bicuspid aortic valv... | KEEP AS NON CORE | Summary: NOTCH1 regulates aortic valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. Supporting Evidence: PMID:17662764 Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms. |
| GO:0003213 cardiac right atrium morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac right atrium morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003222 ventricular trabecula myocardium morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates ventricular trabecula myocardium morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003241 growth involved in heart morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates growth involved in heart morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0007221 positive regulation of transcription of Notch receptor target | ISS GO_REF:0000024 | ACCEPT | Summary: Positive regulation of transcription of Notch receptor target Reason: Core downstream function of NICD. |
| GO:0014031 mesenchymal cell development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 promotes mesenchymal cell development. Reason: EMT regulation - context-dependent function. |
| GO:0030279 negative regulation of ossification | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of ossification. Reason: Context-dependent regulatory function. |
| GO:0045892 negative regulation of DNA-templated transcription | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of dna-templated transcription. Reason: Context-dependent regulatory function. |
| GO:0055008 cardiac muscle tissue morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac muscle tissue morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060045 positive regulation of cardiac muscle cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates positive regulation of cardiac muscle cell proliferation. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060317 cardiac epithelial to mesenchymal transition | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac epithelial to mesenchymal transition. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060411 cardiac septum morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac septum morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060842 arterial endothelial cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates arterial endothelial cell differentiation. Reason: Vascular development - tissue-specific function. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of transcription by rna polymerase ii. Reason: Context-dependent regulatory function. |
| GO:0001947 heart looping | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates heart looping. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003160 endocardium morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates endocardium morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003169 coronary vein morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates coronary vein morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003181 atrioventricular valve morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates atrioventricular valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 promotes epithelial to mesenchymal transition involved in endocardial cushion formation. Reason: EMT regulation - context-dependent function. |
| GO:0003207 cardiac chamber formation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac chamber formation. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003208 cardiac ventricle morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac ventricle morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003209 cardiac atrium morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac atrium morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003214 cardiac left ventricle morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac left ventricle morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0003344 pericardium morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates pericardium morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0030335 positive regulation of cell migration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of cell migration. Reason: Context-dependent regulatory function. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | ACCEPT | Summary: This annotation captures the core receptor or transcriptional-coactivator mechanism. Reason: The cleaved NOTCH1 intracellular domain is a transcriptional coactivator in the RBPJ/MAML complex. This broader transcription/gene-expression term captures that core mechanism; specificity alone is not a reason to demote it. |
| GO:0060843 venous endothelial cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates venous endothelial cell differentiation. Reason: Vascular development - tissue-specific function. |
| GO:0060948 cardiac vascular smooth muscle cell development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates cardiac vascular smooth muscle cell development. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060956 endocardial cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 annotation to endocardial cell differentiation. Reason: Transferred annotation - context-specific function. |
| GO:0060979 vasculogenesis involved in coronary vascular morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates vasculogenesis involved in coronary vascular morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0060982 coronary artery morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates coronary artery morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0061384 heart trabecula morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates heart trabecula morphogenesis. Reason: Cardiac development - tissue-specific developmental function. |
| GO:1901201 regulation of extracellular matrix assembly | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 annotation to regulation of extracellular matrix assembly. Reason: Transferred annotation - context-specific function. |
| GO:0003157 endocardium development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 regulates endocardium development. Reason: Cardiac development - tissue-specific developmental function. |
| GO:0019899 enzyme binding | ISS GO_REF:0000024 | ACCEPT | Summary: Enzyme binding Reason: NOTCH1 binds enzymes involved in its processing. |
| GO:0004857 enzyme inhibitor activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Notch ankyrin repeats can competitively inhibit FIH-dependent HIF hydroxylation. Reason: PMID:17573339 experimentally shows Notch ankyrin-repeat substrates competing with HIF for FIH/HIF1AN and proposes their natural inhibitor function; PMID:18299578 further supports Notch-FIH sequestration and hypoxia-pathway cross-talk. The transferred enzyme-inhibitor function therefore has a mechanistic basis, but its physiological importance is context dependent and separate from canonical Notch signaling. Supporting Evidence: PMID:17573339 ARD proteins were found to efficiently compete with HIF for FIH-dependent hydroxylation. |
| GO:0043086 negative regulation of catalytic activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of catalytic activity. Reason: Context-dependent regulatory function. |
| GO:0002193 MAML1-RBP-Jkappa- ICN1 complex | IDA PMID:16510869 The Notch coactivator, MAML1, functions as a novel coactivat... | ACCEPT | Summary: MAML1-RBP-Jkappa-ICN1 complex Reason: Core transcription activation complex. Supporting Evidence: PMID:16510869 The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. |
| GO:0097150 neuronal stem cell population maintenance | IEP PMID:19682396 Notch signaling is required for maintaining stem-cell featur... | KEEP AS NON CORE | Summary: NOTCH1 is involved in neuronal stem cell population maintenance. Reason: Neural development - tissue-specific function. Supporting Evidence: PMID:19682396 Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells. |
| GO:0005515 protein binding | IPI PMID:16510869 The Notch coactivator, MAML1, functions as a novel coactivat... | REMOVE | Summary: Generic protein binding annotation. Reason: Generic protein binding is uninformative. Specific interactions should be captured by more specific terms. Supporting Evidence: PMID:16510869 The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. |
| GO:0007219 Notch signaling pathway | IMP PMID:19682396 Notch signaling is required for maintaining stem-cell featur... | ACCEPT | Summary: Notch signaling pathway Reason: Core function - NOTCH1 IS the pathway receptor. Supporting Evidence: PMID:19682396 Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells. |
| GO:0008284 positive regulation of cell population proliferation | IDA PMID:17849174 Notch activation promotes cell proliferation and the formati... | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of cell population proliferation. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:17849174 Epub 2007 Sep 12. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. |
| GO:0030513 positive regulation of BMP signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of bmp signaling pathway. Reason: Context-dependent regulatory function. |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in positive regulation of receptor signaling pathway via jak-stat. Reason: Context-dependent regulatory function. |
| GO:2000737 negative regulation of stem cell differentiation | IMP PMID:19682396 Notch signaling is required for maintaining stem-cell featur... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of stem cell differentiation. Reason: Stem cell regulation - context-dependent function. Supporting Evidence: PMID:19682396 Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells. |
| GO:2000974 negative regulation of pro-B cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of pro-b cell differentiation. Reason: Context-dependent regulatory function. |
| GO:0030514 negative regulation of BMP signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of bmp signaling pathway. Reason: Context-dependent regulatory function. |
| GO:0045668 negative regulation of osteoblast differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of osteoblast differentiation. Reason: Context-dependent regulatory function. |
| GO:0045893 positive regulation of DNA-templated transcription | ISS GO_REF:0000024 | ACCEPT | Summary: Positive regulation of DNA-templated transcription Reason: NICD activates transcription. |
| GO:0048711 positive regulation of astrocyte differentiation | ISS GO_REF:0000024 | ACCEPT | Summary: NOTCH1 positively regulates astrocyte differentiation - conserved function from mouse studies. Reason: Core gliogenic function - canonical Notch signaling promotes astrocyte fate. |
| GO:0048715 negative regulation of oligodendrocyte differentiation | ISS GO_REF:0000024 | ACCEPT | Summary: NOTCH1 negatively regulates oligodendrocyte differentiation - conserved function from mouse studies. Reason: Core gliogenic function - NOTCH1 promotes astrocyte over oligodendrocyte fate. |
| GO:0060253 negative regulation of glial cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of glial cell proliferation. Reason: Context-dependent regulatory function. |
| GO:0007507 heart development | IMP PMID:21457232 Identification of de novo mutations and rare variants in hyp... | KEEP AS NON CORE | Summary: NOTCH1 regulates heart development. Reason: Cardiac development - tissue-specific developmental function. Supporting Evidence: PMID:21457232 2011 Apr 25. Identification of de novo mutations and rare variants in hypoplastic left heart syndrome. |
| GO:0010812 negative regulation of cell-substrate adhesion | IDA PMID:16501043 Increased Wnt signaling triggers oncogenic conversion of hum... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of cell-substrate adhesion. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:16501043 Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. |
| GO:0003180 aortic valve morphogenesis | IMP PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. | KEEP AS NON CORE | Summary: NOTCH1 regulates aortic valve morphogenesis. Reason: Cardiac development - tissue-specific developmental function. Supporting Evidence: PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
| GO:0005515 protein binding | IPI PMID:11101851 MAML1, a human homologue of Drosophila mastermind, is a tran... | REMOVE | Summary: Generic protein binding annotation. Reason: Generic protein binding is uninformative. Specific interactions should be captured by more specific terms. Supporting Evidence: PMID:11101851 MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. |
| GO:0005515 protein binding | IPI PMID:11390662 A human protein with sequence similarity to Drosophila maste... | REMOVE | Summary: Generic protein binding annotation. Reason: Generic protein binding is uninformative. Specific interactions should be captured by more specific terms. Supporting Evidence: PMID:11390662 A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. |
| GO:0005634 nucleus | TAS PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin ... | ACCEPT | Summary: Nucleus Reason: NICD translocates to nucleus. Supporting Evidence: PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |
| GO:0006355 regulation of DNA-templated transcription | TAS PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin ... | ACCEPT | Summary: Regulation of DNA-templated transcription Reason: Core transcriptional function. Supporting Evidence: PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |
| GO:0007219 Notch signaling pathway | TAS PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin ... | ACCEPT | Summary: Notch signaling pathway Reason: Core function - NOTCH1 IS the pathway receptor. Supporting Evidence: PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |
| GO:0045662 negative regulation of myoblast differentiation | IMP PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin ... | KEEP AS NON CORE | Summary: NOTCH1 is involved in negative regulation of myoblast differentiation. Reason: Context-dependent regulatory function. Supporting Evidence: PMID:10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |
| GO:0006955 immune response | NAS PMID:1831692 TAN-1, the human homolog of the Drosophila notch gene, is br... | KEEP AS NON CORE | Summary: NOTCH1 regulates immune response. Reason: T cell/immune development - tissue-specific function. Supporting Evidence: PMID:1831692 TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. |
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