NRAS is one of the three canonical human RAS small GTPases (with HRAS and KRAS). It is a peripheral membrane protein anchored to the cytoplasmic face of cellular membranes through C-terminal lipidation (farnesylation at Cys-186 and palmitoylation at Cys-181) and functions as a binary molecular switch that binds GDP/GTP and possesses intrinsic GTPase activity. Cycling between an inactive GDP-bound and an active GTP-bound state under the control of guanine nucleotide exchange factors (GEFs such as SOS1 and RasGRP) and GTPase-activating proteins (GAPs), active GTP-bound NRAS transduces signals from receptor tyrosine kinases to downstream effectors, principally the RAF-MEK-ERK (MAPK) cascade and PI3K, thereby promoting cell proliferation, survival and differentiation. NRAS undergoes a constitutive de/re-palmitoylation acylation cycle that drives rapid shuttling between the plasma membrane and the Golgi apparatus, providing spatial control of signaling. Activating somatic and germline mutations at codons 12, 13 and 61 impair GTP hydrolysis and lock NRAS in its active state, a major oncogenic and developmental-disorder mechanism.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | MODIFY | Summary: NRAS is a lipid-anchored peripheral membrane protein active on the cytoplasmic face of the plasma membrane, where GTP-bound NRAS engages RAF and other effectors. This is a core, well-supported phylogenetic localization for the RAS family. Reason: Plasma membrane is the principal site of action for NRAS signaling and is strongly supported across orthologs (IBA) and by direct experimental evidence in human cells. The more specific supported term is cytoplasmic side of plasma membrane (GO:0009898), supported by the inner-leaflet anchoring/recruitment evidence though not yet a separate GOA row -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Propagation Review Root cause: TERM SCOPING PROBLEM Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. PMID:26701913 ABHD17 catalytic activity is required for N-Ras depalmitoylation and re-localization to internal cellular membranes. |
| GO:0007265 Ras protein signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: Ras protein signal transduction is the defining biological process of NRAS, which acts as a GTP/GDP-regulated switch transducing receptor tyrosine kinase input to downstream effectors (RAF-MEK-ERK, PI3K). Conserved across the RAS family. Reason: This is the central core biological process for NRAS, supported phylogenetically (IBA) and by direct experimental evidence (see the IDA row for PMID:30712867). Supporting Evidence: PMID:30712867 STK19 phosphorylates NRAS to enhance its binding to its downstream effectors and promotes oncogenic NRAS-mediated melanocyte malignant transformation. |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Active NRAS signaling through the MAPK and PI3K pathways promotes cell proliferation, and oncogenic NRAS mutations drive uncontrolled proliferation. This is a genuine but downstream consequence of NRAS signal transduction. Reason: Promotion of proliferation is a real, conserved role of RAS GTPases but is a downstream physiological output of the core GTPase/signal-transduction function rather than the molecular activity itself. Retained as a non-core process. Supporting Evidence: PMID:30712867 Activating mutations in NRAS account for 20%-30% of melanoma. |
| GO:0003924 GTPase activity | IBA GO_REF:0000033 | ACCEPT | Summary: NRAS hydrolyzes GTP to GDP (EC 3.6.5.2), the catalytic activity underlying its switch behavior. Intrinsic GTPase activity is the canonical molecular function of all RAS-family proteins and is impaired by oncogenic codon-12/13/61 mutations. Reason: GTPase activity is a core molecular function, supported phylogenetically (IBA) and directly (PMID:30712867; UniProt FUNCTION/CATALYTIC ACTIVITY). Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. file:human/NRAS/NRAS-uniprot.txt Reaction=GTP + H2O = GDP + phosphate + H(+); ... EC=3.6.5.2 |
| GO:0000139 Golgi membrane | IEA GO_REF:0000044 | ACCEPT | Summary: NRAS localizes to the Golgi apparatus membrane as part of its de/re-palmitoylation acylation cycle, shuttling between the plasma membrane and Golgi. UniProt subcellular location vocabulary maps to this term. Reason: Golgi membrane is an experimentally supported core localization for NRAS (see EXP rows PMID:15705808, PMID:26701913); the UniProt SubCell IEA mapping is consistent. Supporting Evidence: PMID:15705808 driving their rapid exchange between the plasma membrane (PM) and the Golgi apparatus. |
| GO:0000165 MAPK cascade | IEA GO_REF:0000117 | ACCEPT | Summary: NRAS is an upstream activator of the RAF-MEK-ERK MAPK cascade; GTP-bound NRAS recruits and activates RAF kinases, initiating the cascade. Reason: MAPK cascade is a core biological process for NRAS, also supported by Reactome TAS (RAF/MAP kinase cascade) and by direct effector-binding evidence. Supporting Evidence: PMID:18641128 eNOS selectively activates N-Ras but not K-Ras on the Golgi complex of T cells engaged with APC. |
| GO:0003924 GTPase activity | IEA GO_REF:0000002 | ACCEPT | Summary: InterPro small-GTPase signature (IPR001806) maps NRAS to GTPase activity, its canonical catalytic molecular function. Reason: Correct InterPro2GO mapping consistent with the IBA/IDA/ISS GTPase activity rows. Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. |
| GO:0003925 G protein activity | IEA GO_REF:0000003 | KEEP AS NON CORE | Summary: G protein activity is the EC-mapped (EC 3.6.5.2) molecular function for the small monomeric GTPase enzyme class. For NRAS this is the same underlying GTP-hydrolyzing activity captured more specifically as GTPase activity (GO:0003924). Reason: The term is not wrong, but GTPase activity (GO:0003924) is the more standard and specific molecular-function descriptor for RAS proteins and is already present. Retained as a non-core duplicate of the core enzymatic activity rather than the preferred term. Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt Reaction=GTP + H2O = GDP + phosphate + H(+); ... EC=3.6.5.2 |
| GO:0005525 GTP binding | IEA GO_REF:0000002 | ACCEPT | Summary: NRAS binds GTP (and GDP) via its conserved P-loop and G-box motifs; nucleotide binding is the basis of its switch function. InterPro small-GTPase signatures map here. Reason: GTP binding is a core molecular function directly supported by the crystal structure (GDP-bound) and the conserved GTP-binding sites in the UniProt record. Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | MODIFY | Summary: Plasma membrane localization of NRAS via the UniProt SubCell vocabulary mapping, consistent with its lipid-anchored peripheral membrane attachment. Reason: Core localization, redundant with the IBA/IDA/EXP plasma membrane rows. The more specific supported term is cytoplasmic side of plasma membrane (GO:0009898), supported by the inner-leaflet anchoring/recruitment evidence though not yet a separate GOA row -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0007165 signal transduction | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Generic signal transduction is correct for NRAS but is a broad parent of the more specific and better-supported Ras protein signal transduction (GO:0007265) and MAPK cascade (GO:0000165) annotations already present. Reason: Not wrong, but less informative than the specific Ras-signal-transduction terms. Retained as a non-core broad classifier. Supporting Evidence: PMID:30712867 STK19 phosphorylates NRAS to enhance its binding to its downstream effectors and promotes oncogenic NRAS-mediated melanocyte malignant transformation. |
| GO:0016020 membrane | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Generic membrane localization from the InterPro small-GTPase mapping. NRAS is a membrane-anchored protein, but the specific plasma-membrane and Golgi-membrane terms are far more informative. Reason: The bare membrane term loses the diagnostic plasma-membrane/Golgi-membrane specificity that is well established for NRAS. Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005515 protein binding | IPI PMID:18641128 Endothelial nitric oxide synthase regulates N-Ras activation... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with RAF1 (P04049), assayed as RBD-Raf-1 redistribution reporting N-Ras activation on the Golgi. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18641128 as indicated by the redistribution of RBD-Raf-1 toward this organelle PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:20080631 Ras membrane orientation and nanodomain localization generat... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with RAF1 (P04049) in a study of Ras membrane orientation and nanodomain localization. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:21478863 ERK and PDE4 cooperate to induce RAF isoform switching in me... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with RAF1, BRAF and RAF isoforms in a study of RAF isoform switching in melanoma. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: IPI evidence for physical interaction of NRAS with RIN1 (Q13671). Reason: Bare protein binding is uninformative. RIN1 is a non-catalytic (with respect to Ras) effector; no more specific NRAS molecular function term applies. The interaction was detected in a large-scale interactome screen. Removal does not mean the interaction is false; it reflects the lack of functional information carried by bare GO:0005515, and the interaction remains recorded in the interaction databases and UniProt. |
| GO:0005515 protein binding | IPI PMID:30194290 Interrogating the protein interactomes of RAS isoforms ident... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with RAF1 and BRAF (P04049, P15056) in a proximity-labeling RAS isoform interactome. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:31209342 GGTase3 is a newly identified geranylgeranyltransferase targ... | REMOVE | Summary: IPI evidence for physical interaction of NRAS with the farnesyltransferase/GGTase alpha subunit FNTA (P49354). Reason: Bare protein binding is uninformative. NRAS is a substrate of protein farnesyltransferase; this enzyme-substrate relationship belongs on the enzyme (has input) rather than as an NRAS molecular function. Removal does not mean the interaction is false; it reflects the lack of functional information carried by bare GO:0005515, and the interaction remains recorded in the interaction databases and UniProt. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with RAF1 (P04049) in an EGFR-network interactome of colorectal cancer cells. The interaction was detected in a large-scale interactome screen.. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MODIFY | Summary: IPI evidence for physical interaction of NRAS with RAF1, RIN1, RGL3, RAP1GDS1 and other proteins in the HuRI binary interactome. The interaction was detected in a large-scale interactome screen.. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with BRAF (P15056) in a kinase interaction network. The interaction was detected in a large-scale interactome screen.. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI evidence for physical interaction of NRAS with a PIK3R1 isoform (P27986-2). Reason: Bare protein binding is uninformative. This yeast two-hybrid hit with the PI3K regulatory subunit (rather than the Ras-binding p110 catalytic subunit) lacks functional characterization. The interaction was detected in a large-scale interactome screen. Removal does not mean the interaction is false; it reflects the lack of functional information carried by bare GO:0005515, and the interaction remains recorded in the interaction databases and UniProt. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: IPI evidence for physical interaction of NRAS with RIN1 (Q13671) (BioPlex). Reason: Bare protein binding is uninformative. RIN1 is a non-catalytic (with respect to Ras) effector; no more specific NRAS molecular function term applies. The interaction was detected in a large-scale interactome screen. Removal does not mean the interaction is false; it reflects the lack of functional information carried by bare GO:0005515, and the interaction remains recorded in the interaction databases and UniProt. |
| GO:0005515 protein binding | IPI PMID:34591642 A protein network map of head and neck cancer reveals PIK3CA... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with RAF1, BRAF and RIN1. The interaction was detected in a large-scale interactome screen.. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with BRAF (P15056). The interaction was detected in a large-scale interactome screen.. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:35839996 A Proteomic Approach Identifies Isoform-Specific and Nucleot... | MODIFY | Summary: IPI evidence for physical interaction of NRAS with RAF1, FNTA and RADIL in a nucleotide- dependent RAS interactome study. Reason: Bare protein binding is uninformative. The interaction partners include RAF-family serine/threonine kinases, which GTP-bound RAS engages through their Ras-binding domain as the canonical MAPK-pathway effector interaction, so the evidence is better captured by protein kinase binding. Proposed replacements: protein kinase binding Supporting Evidence: PMID:35839996 The RADIL–RAS interactions were nearly identical to the known RAS effector RAF1 with one interesting difference PMID:30194290 Among these were the well-described RAS effectors ARAF, BRAF, and RAF1 (CRAF), which directly bind to activated RAS through a Ras-binding domain |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: IPI evidence for physical interaction of NRAS with RIN1 (Q13671). Reason: Bare protein binding is uninformative. RIN1 is a non-catalytic (with respect to Ras) effector; no more specific NRAS molecular function term applies. The interaction was detected in a large-scale interactome screen. Removal does not mean the interaction is false; it reflects the lack of functional information carried by bare GO:0005515, and the interaction remains recorded in the interaction databases and UniProt. |
| GO:0000165 MAPK cascade | TAS Reactome:R-HSA-5673001 | ACCEPT | Summary: Reactome places NRAS in the RAF/MAP kinase cascade, consistent with its core role as an upstream activator of RAF-MEK-ERK signaling. Reason: Core biological process, concordant with the IEA MAPK cascade row and effector-binding evidence. Supporting Evidence: Reactome:R-HSA-5673001 RAF/MAP kinase cascade. |
| GO:0046579 positive regulation of Ras protein signal transduction | NAS PMID:35831509 Structure-function analysis of the SHOC2-MRAS-PP1C holophosp... | KEEP AS NON CORE | Summary: Active GTP-bound NRAS binds the SHOC2-PP1C holophosphatase complex, which dephosphorylates inhibitory sites on RAF to promote RAF activation, positively regulating Ras/MAPK signaling. This NAS annotation derives from the ComplexPortal SHOC2-NRAS-PPP1CA complex. Reason: This represents NRAS participation in a positive-feedback/effector-activation complex rather than its core intrinsic GTPase switch activity. It is a valid, more specialized process, retained as non-core. Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt Interacts (active GTP-bound form) with both SHOC2 and PP1c (all isoforms) to form a tertiary complex; SHOC2 and PP1c preferably bind M-Ras/MRAS, but they also bind K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | MODIFY | Summary: Immunofluorescence (Human Protein Atlas) localizes NRAS to the plasma membrane, consistent with its lipid-anchored membrane attachment. Reason: Direct (IDA) support for the core plasma-membrane localization. The more specific supported term is cytoplasmic side of plasma membrane (GO:0009898), supported by the inner-leaflet anchoring/recruitment evidence though not yet a separate GOA row -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0000139 Golgi membrane | EXP PMID:15705808 An acylation cycle regulates localization and activity of pa... | ACCEPT | Summary: NRAS is experimentally localized to the Golgi apparatus membrane, where the de/re-palmitoylation acylation cycle traps farnesylated Ras before redirection to the plasma membrane. Reason: Direct experimental support for core Golgi-membrane localization as part of the PM-Golgi shuttling cycle. Supporting Evidence: PMID:15705808 Depalmitoylation redistributes farnesylated Ras in all membranes, followed by repalmitoylation and trapping of Ras at the Golgi, from where it is redirected to the PM via the secretory pathway. |
| GO:0000139 Golgi membrane | EXP PMID:26701913 ABHD17 proteins are novel protein depalmitoylases that regul... | ACCEPT | Summary: NRAS localizes to Golgi/internal membranes, with ABHD17 depalmitoylase activity controlling its palmitate turnover and relocalization between plasma membrane and internal membranes. Reason: Direct experimental support for core Golgi-membrane localization in the context of palmitoylation-dependent trafficking. Supporting Evidence: PMID:26701913 ABHD17 catalytic activity is required for N-Ras depalmitoylation and re-localization to internal cellular membranes. |
| GO:0003924 GTPase activity | ISS GO_REF:0000024 | ACCEPT | Summary: GTPase activity transferred by sequence similarity from KRAS (P01116). NRAS shares the canonical RAS catalytic machinery and intrinsic GTPase activity. Reason: Correct similarity-based assignment of the core GTPase molecular function, fully concordant with the IBA/IDA evidence. Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. |
| GO:0005886 plasma membrane | EXP PMID:15705808 An acylation cycle regulates localization and activity of pa... | MODIFY | Summary: NRAS is experimentally localized to the plasma membrane, the principal signaling site, as part of the PM-Golgi acylation shuttling cycle. Reason: Direct experimental support for the core plasma-membrane localization. The more specific supported term is cytoplasmic side of plasma membrane (GO:0009898), supported by the inner-leaflet anchoring/recruitment evidence though not yet a separate GOA row -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: PMID:15705808 driving their rapid exchange between the plasma membrane (PM) and the Golgi apparatus. |
| GO:0005886 plasma membrane | EXP PMID:26701913 ABHD17 proteins are novel protein depalmitoylases that regul... | MODIFY | Summary: NRAS plasma-membrane localization is palmitoylation-dependent; ABHD17 depalmitoylase activity drives N-Ras relocalization from the plasma membrane to internal membranes, and loss of palmitoylation (Cys181Ser) abolishes plasma-membrane localization. Reason: Direct experimental support for the core plasma-membrane localization. The more specific supported term is cytoplasmic side of plasma membrane (GO:0009898), supported by the inner-leaflet anchoring/recruitment evidence though not yet a separate GOA row -- the protein is lipid-anchored or recruited to the inner (cytoplasmic) leaflet and faces the cytosol, not the cell exterior. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: PMID:26701913 ABHD17 catalytic activity is required for N-Ras depalmitoylation and re-localization to internal cellular membranes. |
| GO:0003924 GTPase activity | TAS Reactome:R-HSA-9649736 | ACCEPT | Summary: Reactome attributes GTPase activity to NRAS, its canonical catalytic molecular function. Reason: Concordant with the core GTPase activity annotations (IBA/IDA/ISS/IEA). Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-9647980 | ACCEPT | Summary: Reactome RAS-processing/localization events place NRAS at the Golgi apparatus membrane, a bona-fide localization in its PM-Golgi shuttling cycle. Reason: Concordant with the experimentally supported core Golgi-membrane localization. Supporting Evidence: PMID:15705808 driving their rapid exchange between the plasma membrane (PM) and the Golgi apparatus. |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-9647982 | ACCEPT | Summary: Reactome RAS-processing/localization events place NRAS at the Golgi apparatus membrane, a bona-fide localization in its PM-Golgi shuttling cycle. Reason: Concordant with the experimentally supported core Golgi-membrane localization. Supporting Evidence: PMID:15705808 driving their rapid exchange between the plasma membrane (PM) and the Golgi apparatus. |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-9647977 | KEEP AS NON CORE | Summary: Reactome RAS-processing events localize NRAS to the endoplasmic reticulum membrane, where post-translational CAAX processing (RCE1/ICMT) of newly farnesylated Ras occurs en route to the Golgi and plasma membrane. Reason: ER membrane is a transient processing/transit site rather than the principal signaling location (plasma membrane/Golgi). Retained as a non-core localization supported only by Reactome pathway knowledge. Supporting Evidence: PMID:15705808 from where it is redirected to the PM via the secretory pathway. |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-9647978 | KEEP AS NON CORE | Summary: Reactome RAS-processing events localize NRAS to the endoplasmic reticulum membrane, where post-translational CAAX processing (RCE1/ICMT) of newly farnesylated Ras occurs en route to the Golgi and plasma membrane. Reason: ER membrane is a transient processing/transit site rather than the principal signaling location (plasma membrane/Golgi). Retained as a non-core localization supported only by Reactome pathway knowledge. Supporting Evidence: PMID:15705808 from where it is redirected to the PM via the secretory pathway. |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-9647982 | KEEP AS NON CORE | Summary: Reactome RAS-processing events localize NRAS to the endoplasmic reticulum membrane, where post-translational CAAX processing (RCE1/ICMT) of newly farnesylated Ras occurs en route to the Golgi and plasma membrane. Reason: ER membrane is a transient processing/transit site rather than the principal signaling location (plasma membrane/Golgi). Retained as a non-core localization supported only by Reactome pathway knowledge. Supporting Evidence: PMID:15705808 from where it is redirected to the PM via the secretory pathway. |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-9647999 | KEEP AS NON CORE | Summary: Reactome RAS-processing events localize NRAS to the endoplasmic reticulum membrane, where post-translational CAAX processing (RCE1/ICMT) of newly farnesylated Ras occurs en route to the Golgi and plasma membrane. Reason: ER membrane is a transient processing/transit site rather than the principal signaling location (plasma membrane/Golgi). Retained as a non-core localization supported only by Reactome pathway knowledge. Supporting Evidence: PMID:15705808 from where it is redirected to the PM via the secretory pathway. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1168636 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1225951 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1225957 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1250383 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1306972 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1433471 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-170986 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-177938 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-177945 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-186834 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-210977 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2179407 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2424477 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-392054 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5218845 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5621573 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5624486 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5624492 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5624494 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5637806 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5637808 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654392 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654402 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654413 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654426 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654600 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654618 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654647 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654663 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655241 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655277 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655326 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655347 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5658231 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5658435 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672950 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672965 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672966 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672969 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672972 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672973 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672978 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672980 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5674018 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5674022 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5675417 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5675431 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5675433 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802837 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8851827 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8851877 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8851899 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8941613 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8941618 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8941623 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8941628 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8981353 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8981355 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9607304 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9632906 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9632918 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9634418 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9647980 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9647994 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9649733 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9649735 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9649736 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9653108 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9656209 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9656211 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9656212 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9656213 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9656214 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9656215 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9657599 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9657603 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9657606 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9657608 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9658253 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9664991 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9665009 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9665404 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9665408 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9665700 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9665707 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9670436 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9672163 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9672170 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9695853 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9703441 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9647978 | KEEP AS NON CORE | Summary: Reactome localizes newly synthesized, pre-processed (farnesylated but not yet membrane-anchored) NRAS to the cytosol during RAS processing. Reason: Cytosolic localization applies transiently to nascent unprocessed NRAS; the mature, functionally active protein is membrane-anchored. Retained as a non-core processing-stage location. Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802834 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802908 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802918 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802922 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802924 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802925 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802926 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802937 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802941 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802942 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802943 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6803233 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6803234 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6803240 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8936731 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9651280 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0003924 GTPase activity | IDA PMID:30712867 Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-D... | ACCEPT | Summary: Direct experimental study of NRAS function, including characterization of the oncogenic Q61R variant and STK19-mediated Ser-89 phosphorylation; UniProt cites this work (ECO:0000269|PubMed:30712867) for NRAS GDP/GTP binding and intrinsic GTPase activity. Reason: Provides direct experimental (IDA) support for the core GTPase molecular function of NRAS. Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. {ECO:0000269|PubMed:30712867}. |
| GO:0007265 Ras protein signal transduction | IDA PMID:30712867 Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-D... | ACCEPT | Summary: NRAS transduces signals to downstream effectors; STK19 phosphorylates NRAS at Ser-89 to enhance effector binding and promote oncogenic NRAS-driven melanocyte transformation, providing direct evidence for NRAS signal transduction. Reason: Direct experimental (IDA) support for the core Ras-protein-signal-transduction process. Supporting Evidence: PMID:30712867 STK19 phosphorylates NRAS to enhance its binding to its downstream effectors and promotes oncogenic NRAS-mediated melanocyte malignant transformation. |
| GO:0044877 protein-containing complex binding | IDA PMID:23209302 KIF14 negatively regulates Rap1a-Radil signaling during brea... | MARK AS OVER ANNOTATED | Summary: This annotation derives from a study focused on KIF14 and Rap1a-Radil signaling in breast cancer; NRAS is not the subject of that work, and the protein-containing complex binding term is generic. Reason: The cited paper does not characterize a specific NRAS molecular function; the generic complex-binding term adds little beyond NRAS's established effector/regulator interactions already captured by its signal-transduction annotations. Supporting Evidence: PMID:23209302 KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. |
| GO:0001938 positive regulation of endothelial cell proliferation | IMP PMID:23619365 MicroRNA-146a is a therapeutic target and biomarker for peri... | KEEP AS NON CORE | Summary: In endothelial cells, miR-146a downregulates NRAS and thereby attenuates angiogenesis, implying that NRAS normally supports endothelial cell proliferation and angiogenesis. This is a tissue-specific downstream output of NRAS/MAPK signaling. Reason: The role in endothelial cell proliferation is a peripheral, cell-type-specific consequence of the core NRAS signaling function rather than its defining activity. Retained as a non-core process. Supporting Evidence: PMID:23619365 which attenuated angiogenesis through downregulation of NRAS. |
| GO:0070821 tertiary granule membrane | TAS Reactome:R-HSA-6798747 | MARK AS OVER ANNOTATED | Summary: This Reactome annotation (neutrophil degranulation pathway) places NRAS at the tertiary granule membrane in neutrophils. It reflects pathway-level granule-proteome membership rather than a core functional localization. Reason: Tertiary granule membrane is a cell-type-specific membrane compartment derived from a degranulation proteome pathway; it is far less informative than the established plasma membrane/Golgi localizations and does not represent the core site of NRAS signaling. Supporting Evidence: Reactome:R-HSA-6798747 Neutrophil degranulation. |
| GO:0016020 membrane | HDA PMID:19946888 Defining the membrane proteome of NK cells. | MARK AS OVER ANNOTATED | Summary: NRAS was detected in a high-throughput NK-cell membrane proteome. Generic membrane localization is consistent with NRAS being a membrane-anchored protein but is much less informative than its specific plasma-membrane/Golgi-membrane localizations. Reason: The bare membrane term from a proteomic dataset loses the diagnostic plasma-membrane/Golgi specificity already well established for NRAS. Supporting Evidence: PMID:19946888 Defining the membrane proteome of NK cells. |
| GO:0070062 extracellular exosome | HDA PMID:20458337 MHC class II-associated proteins in B-cell exosomes and pote... | KEEP AS NON CORE | Summary: Detected in an extracellular-vesicle proteome. The protein is plausible EV content, but this is not where it functions. Reason: Lipid-anchored plasma-membrane GTPase (cytoplasmic face). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. (Manual re-review for OMICS_EVIDENCE, 2026-10-10; previous action: MARK_AS_OVER_ANNOTATED.) Supporting Evidence: PMID:20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6798747 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802914 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802915 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802916 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802919 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6802921 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-6803230 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8936676 | MODIFY | Summary: Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. NRAS is lipid-anchored on the cytoplasmic (inner) leaflet, so the precise location is the cytoplasmic side of the plasma membrane. Reason: The plasma-membrane localization is correct and is the core signaling site, but NRAS is farnesylated/palmitoylated and faces the cytosol; the more specific supported term, which UniProt states directly (Cytoplasmic side), is cytoplasmic side of plasma membrane (GO:0009898). The many Reactome rows are redundant reaction-level participations that all assert the same placement. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: file:human/NRAS/NRAS-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. |
| GO:0005794 Golgi apparatus | IDA PMID:21968647 PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparat... | ACCEPT | Summary: NRAS localizes to and is activated at the Golgi apparatus; the Golgi-resident proteins PAQR10/PAQR11 interact with NRAS and elevate its Golgi localization and activation, providing direct evidence for Golgi localization. Reason: Direct experimental support for the core Golgi-apparatus localization, consistent with the Golgi-membrane annotations and the PM-Golgi shuttling model. (The part_of qualifier is atypical for an organelle localization, but the underlying Golgi localization is sound.) Supporting Evidence: PMID:21968647 Overexpression of PAQR10/PAQR11 markedly elevates Golgi localization of HRas, NRas and KRas4A, but not KRas4B. |
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Download this section (compressed HTML)Q: To what extent are NRAS-specific (versus pan-RAS) downstream signaling outputs and effector preferences attributable to its hypervariable region and its distinctive palmitoylation/depalmitoylation-driven PM-Golgi trafficking?
Suggested experts: McCormick F, Bastiaens PIH
Q: Should NRAS receive a distinct molecular-function annotation for RAF/effector binding (e.g., a Ras-effector engagement term) given the many curated effector interactions currently captured only as generic protein binding?
Suggested experts: Thomas GV
Experiment: Use acylation-cycle mutants (e.g., Cys181Ser) and ABHD17/ZDHHC9 perturbations combined with FRET-based Ras activity biosensors and phospho-ERK readouts to map how subcellular localization governs NRAS-driven MAPK activation.
Hypothesis: NRAS effector engagement and signaling output are quantitatively shaped by its palmitoylation-dependent localization between plasma membrane and Golgi.
Type: live-cell signaling and localization assay
Experiment: Compare effector co-immunoprecipitation, GTP-loading, and downstream ERK activation for wild-type, S89A, and oncogenic (Q61R) NRAS in STK19-proficient versus STK19-deficient cells.
Hypothesis: Ser-89 phosphorylation by STK19 selectively enhances oncogenic NRAS effector binding and MAPK output.
Type: biochemical effector-binding and phosphorylation assay
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