PDGFA

UniProt ID: P04085
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for PDGFA

Existing Annotations Review

GO Term Evidence Action Reason
GO:0008284 positive regulation of cell population proliferation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030335 positive regulation of cell migration
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001525 angiogenesis
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048008 platelet-derived growth factor receptor signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005161 platelet-derived growth factor receptor binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008083 growth factor activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048018 receptor ligand activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051781 positive regulation of cell division
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25241761
Using an in situ proximity ligation assay to systematically ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25241761
Oct 9. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
GO:0005515 protein binding
IPI
PMID:7679113
Mechanism of platelet-derived growth factor (PDGF) AA, AB, a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7679113
Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
GO:0005615 extracellular space
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005902 microvillus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048565 digestive tract development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990401 embryonic lung development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway
NAS
PMID:11297552
Platelet-derived growth factor C (PDGF-C), a novel growth fa... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11297552
2001 Apr 10. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
GO:0038083 peptidyl-tyrosine autophosphorylation
NAS
PMID:11297552
Platelet-derived growth factor C (PDGF-C), a novel growth fa... 		REMOVE
Summary: MISANNOTATION: PDGFA is a secreted LIGAND for PDGF receptors (PDGFRA/PDGFRB). It has NO kinase activity and cannot autophosphorylate. When PDGF binds, the PDGF RECEPTORS autophosphorylate - not the ligand. GO:0038083 "peptidyl-tyrosine autophosphorylation" should be annotated to the receptor, not the ligand.
Supporting Evidence:
PMID:11297552
2001 Apr 10. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
GO:0048008 platelet-derived growth factor receptor signaling pathway
NAS
PMID:7679113
Mechanism of platelet-derived growth factor (PDGF) AA, AB, a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7679113
Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway
NAS
PMID:7679113
Mechanism of platelet-derived growth factor (PDGF) AA, AB, a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7679113
Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:10806482
PDGF-C is a new protease-activated ligand for the PDGF alpha... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10806482
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarco... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication.
GO:0005796 Golgi lumen
TAS
Reactome:R-HSA-186785 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005796 Golgi lumen
TAS
Reactome:R-HSA-8865276 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005161 platelet-derived growth factor receptor binding
IDA
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarco... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication.
GO:1990401 embryonic lung development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008083 growth factor activity
IDA
PMID:12070119
Adipocyte-derived plasma protein adiponectin acts as a plate... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12070119
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell.
GO:0009986 cell surface
IDA
PMID:2538439
Collagen-induced binding to human platelets of platelet-deri... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2538439
Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation.
GO:0000139 Golgi membrane
TAS
Reactome:R-HSA-186785 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000139 Golgi membrane
TAS
Reactome:R-HSA-382053 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-1524182 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-1524186 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186765 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186773 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186778 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186780 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186785 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186800 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186819 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186826 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-186834 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-2316434 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-2400009 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-380780 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-380782 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-382052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-382054 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-382055 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-382056 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-382058 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-389083 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-481007 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-5672965 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-9674093 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005788 endoplasmic reticulum lumen
TAS
Reactome:R-HSA-382053 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031093 platelet alpha granule lumen
TAS
Reactome:R-HSA-481007 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000139 Golgi membrane
TAS
Reactome:R-HSA-8865276 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-2396337 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-389086 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-8864036 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-8865276 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-9796072 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
IDA
PMID:19019919
PDGF receptor-{beta} modulates metanephric mesenchyme chemot... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19019919
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.
GO:0001525 angiogenesis
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001942 hair follicle development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002053 positive regulation of mesenchymal cell proliferation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005902 microvillus
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009887 animal organ morphogenesis
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030031 cell projection assembly
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030036 actin cytoskeleton organization
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043588 skin development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048286 lung alveolus development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060683 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030335 positive regulation of cell migration
IDA
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat met... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
GO:0043410 positive regulation of MAPK cascade
IMP
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat met... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IDA
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat met... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IDA
PMID:19019919
PDGF receptor-{beta} modulates metanephric mesenchyme chemot... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19019919
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.
GO:0070374 positive regulation of ERK1 and ERK2 cascade
IDA
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat met... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
GO:0072124 regulation of glomerular mesangial cell proliferation
IDA NOT
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat met... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
GO:2000278 regulation of DNA biosynthetic process
IDA NOT
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat met... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
GO:2000278 regulation of DNA biosynthetic process
IDA NOT
PMID:19019919
PDGF receptor-{beta} modulates metanephric mesenchyme chemot... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19019919
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.
GO:0005518 collagen binding
IDA
PMID:8900172
Type I, II, III, IV, V, and VI collagens serve as extracellu... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8900172
Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB).
GO:0014910 regulation of smooth muscle cell migration
IDA
PMID:9409235
Platelet-derived growth factor beta-receptors can both promo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9409235
Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells.
GO:0050919 negative chemotaxis
IDA
PMID:9409235
Platelet-derived growth factor beta-receptors can both promo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9409235
Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells.
GO:0001775 cell activation
TAS
PMID:10508235
Mechanism of action and in vivo role of platelet-derived gro... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10508235
Mechanism of action and in vivo role of platelet-derived growth factor.
GO:0005161 platelet-derived growth factor receptor binding
IPI
PMID:2536956
Isolation of a novel receptor cDNA establishes the existence... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2536956
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:17470632
Vascular endothelial growth factor can signal through platel... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17470632
Apr 30. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
GO:0030335 positive regulation of cell migration
IDA
PMID:17470632
Vascular endothelial growth factor can signal through platel... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17470632
Apr 30. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
GO:0032956 regulation of actin cytoskeleton organization
TAS
PMID:10508235
Mechanism of action and in vivo role of platelet-derived gro... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10508235
Mechanism of action and in vivo role of platelet-derived growth factor.
GO:0042060 wound healing
TAS
PMID:10508235
Mechanism of action and in vivo role of platelet-derived gro... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10508235
Mechanism of action and in vivo role of platelet-derived growth factor.
GO:0048008 platelet-derived growth factor receptor signaling pathway
IDA
PMID:2536956
Isolation of a novel receptor cDNA establishes the existence... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2536956
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.
GO:0048146 positive regulation of fibroblast proliferation
IDA
PMID:10806482
PDGF-C is a new protease-activated ligand for the PDGF alpha... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10806482
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
GO:0005161 platelet-derived growth factor receptor binding
IDA
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B f... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
GO:0005615 extracellular space
IDA
PMID:3754619
cDNA sequence and chromosomal localization of human platelet... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:3754619
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B f... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:7073684
Platelet-derived growth factor: identification of constituen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7073684
Platelet-derived growth factor: identification of constituent polypeptide chains.
GO:0009611 response to wounding
IDA
PMID:2538439
Collagen-induced binding to human platelets of platelet-deri... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2538439
Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation.
GO:0009986 cell surface
IDA
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B f... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
GO:0009986 cell surface
IDA
PMID:291037
Platelet-derived growth factor: purification and partial cha... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:291037
Platelet-derived growth factor: purification and partial characterization.
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
IDA
PMID:2538439
Collagen-induced binding to human platelets of platelet-deri... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2538439
Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation.
GO:0010544 negative regulation of platelet activation
IDA
PMID:2538439
Collagen-induced binding to human platelets of platelet-deri... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2538439
Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation.
GO:0042803 protein homodimerization activity
IDA
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B f... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
GO:0042803 protein homodimerization activity
IDA
PMID:3754619
cDNA sequence and chromosomal localization of human platelet... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:3754619
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.
GO:0046982 protein heterodimerization activity
IPI
PMID:7073684
Platelet-derived growth factor: identification of constituen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7073684
Platelet-derived growth factor: identification of constituent polypeptide chains.
GO:0048008 platelet-derived growth factor receptor signaling pathway
IDA
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarco... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication.
GO:0048008 platelet-derived growth factor receptor signaling pathway
IDA
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B f... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
GO:0048146 positive regulation of fibroblast proliferation
IDA
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarco... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication.
GO:0048407 platelet-derived growth factor binding
IPI
PMID:7073684
Platelet-derived growth factor: identification of constituen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7073684
Platelet-derived growth factor: identification of constituent polypeptide chains.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:16462734
VEGF-C is a trophic factor for neural progenitors in the ver... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16462734
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
GO:0007267 cell-cell signaling
TAS
PMID:2842868
Comparison of biological properties and transforming potenti... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2842868
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10508235
Mechanism of action and in vivo role of platelet-derived growth factor.
PMID:10806482
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
PMID:11297552
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
PMID:11788434
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
PMID:12070119
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell.
PMID:16462734
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
PMID:17470632
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
PMID:19019919
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.
PMID:2439522
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication.
PMID:25241761
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
PMID:2536956
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.
PMID:2538439
Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation.
PMID:2836953
A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
PMID:2842868
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains.
PMID:291037
Platelet-derived growth factor: purification and partial characterization.
PMID:3754619
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.
PMID:7073684
Platelet-derived growth factor: identification of constituent polypeptide chains.
PMID:7679113
Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
PMID:8900172
Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB).
PMID:9409235
Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells.
Reactome:R-HSA-1524182
Activated PLC gamma dissociates from the PDGF receptor
Reactome:R-HSA-1524186
Phosphorylation of PLCgamma by PDGFR
Reactome:R-HSA-186765
PLC-gamma binds to the active receptor
Reactome:R-HSA-186773
PDGF dimer binds two receptors simultaneously
Reactome:R-HSA-186778
SHP2 binds to the active receptor
Reactome:R-HSA-186780
PI3-kinase binds to the active receptor
Reactome:R-HSA-186785
PDGF-AA clevage by Furin
Reactome:R-HSA-186800
PI3K catalyses the phosphorylation of PIP2 to PIP3
Reactome:R-HSA-186819
SH2 domain of Src binds to the active receptor
Reactome:R-HSA-186826
GRB2:SOS1 complex binds to the active receptor
Reactome:R-HSA-186834
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
Reactome:R-HSA-2316434
PI3K phosphorylates PIP2 to PIP3
Reactome:R-HSA-2396337
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer
Reactome:R-HSA-2400009
PI3K inhibitors block PI3K catalytic activity
Reactome:R-HSA-380780
TODO: Fetch title
Reactome:R-HSA-380782
STAT binds to the active receptor
Reactome:R-HSA-382052
p130Cas and C3G bind PDGFR bound Crk
Reactome:R-HSA-382053
TODO: Fetch title
Reactome:R-HSA-382054
PDGF binds to extracellular matrix proteins
Reactome:R-HSA-382055
Grb7 binds to the active PDGF receptor
Reactome:R-HSA-382056
Crk binds to the active PDGF receptor
Reactome:R-HSA-382058
Nck binds to the active PDGF receptor
Reactome:R-HSA-389083
Autophosphorylation of PDGF alpha receptors
Reactome:R-HSA-389086
Autophosphorylation of PDGF alpha/beta receptors
Reactome:R-HSA-481007
Exocytosis of platelet alpha granule contents
Reactome:R-HSA-5672965
RAS GEFs promote RAS nucleotide exchange
Reactome:R-HSA-8864036
PTPN12 dephosphorylates PDGFRB at Y1021
Reactome:R-HSA-8865276
PDGF-AB clevage by Furin
Reactome:R-HSA-9674093
PDGFRs bind type I TKI
Reactome:R-HSA-9796072
NFE2L2 dependent PDGFA expression

📄 View Raw YAML

 
id: P04085
gene_symbol: PDGFA
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for PDGFA'
existing_annotations:
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051781
      label: positive regulation of cell division
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25241761
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25241761
          supporting_text: Oct 9. Using an in situ proximity ligation assay to 
            systematically profile endogenous protein-protein interactions in a 
            pathway network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7679113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) 
            AA, AB, and BB binding to alpha and beta PDGF receptor.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005902
      label: microvillus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048565
      label: digestive tract development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990401
      label: embryonic lung development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035790
      label: platelet-derived growth factor receptor-alpha signaling pathway
    evidence_type: NAS
    original_reference_id: PMID:11297552
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11297552
          supporting_text: 2001 Apr 10. Platelet-derived growth factor C 
            (PDGF-C), a novel growth factor that binds to PDGF alpha and beta 
            receptor.
  - term:
      id: GO:0038083
      label: peptidyl-tyrosine autophosphorylation
    evidence_type: NAS
    original_reference_id: PMID:11297552
    review:
      summary: >-
        MISANNOTATION: PDGFA is a secreted LIGAND for PDGF receptors (PDGFRA/PDGFRB).
        It
        has NO kinase activity and cannot autophosphorylate. When PDGF binds, the
        PDGF
        RECEPTORS autophosphorylate - not the ligand. GO:0038083 "peptidyl-tyrosine
        autophosphorylation" should be annotated to the receptor, not the ligand.
      action: REMOVE
      supported_by:
        - reference_id: PMID:11297552
          supporting_text: 2001 Apr 10. Platelet-derived growth factor C 
            (PDGF-C), a novel growth factor that binds to PDGF alpha and beta 
            receptor.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: NAS
    original_reference_id: PMID:7679113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) 
            AA, AB, and BB binding to alpha and beta PDGF receptor.
  - term:
      id: GO:0035790
      label: platelet-derived growth factor receptor-alpha signaling pathway
    evidence_type: NAS
    original_reference_id: PMID:7679113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) 
            AA, AB, and BB binding to alpha and beta PDGF receptor.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:10806482
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10806482
          supporting_text: PDGF-C is a new protease-activated ligand for the 
            PDGF alpha-receptor.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human 
            osteosarcoma cells but does not stimulate cell replication.
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186785
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human 
            osteosarcoma cells but does not stimulate cell replication.
  - term:
      id: GO:1990401
      label: embryonic lung development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IDA
    original_reference_id: PMID:12070119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as 
            a platelet-derived growth factor-BB-binding protein and regulates 
            growth factor-induced common postreceptor signal in vascular smooth 
            muscle cell.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of 
            platelet-derived growth factor leading to inhibition of P43 and P20 
            phosphorylation.
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186785
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1524182
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1524186
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186765
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186773
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186778
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186780
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186785
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186800
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186819
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186826
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186834
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2316434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2400009
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-380780
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-380782
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382054
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382055
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382056
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389083
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-481007
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5672965
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9674093
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005788
      label: endoplasmic reticulum lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031093
      label: platelet alpha granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-481007
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2396337
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389086
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8864036
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9796072
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035793
      label: positive regulation of metanephric mesenchymal cell migration by 
        platelet-derived growth factor receptor-beta signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001942
      label: hair follicle development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002053
      label: positive regulation of mesenchymal cell proliferation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005902
      label: microvillus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009887
      label: animal organ morphogenesis
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030031
      label: cell projection assembly
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030036
      label: actin cytoskeleton organization
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043588
      label: skin development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048286
      label: lung alveolus development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060683
      label: regulation of branching involved in salivary gland morphogenesis by
        epithelial-mesenchymal signaling
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IMP
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0072124
      label: regulation of glomerular mesangial cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:11788434
    negated: true
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:2000278
      label: regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:11788434
    negated: true
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:2000278
      label: regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:19019919
    negated: true
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
  - term:
      id: GO:0005518
      label: collagen binding
    evidence_type: IDA
    original_reference_id: PMID:8900172
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8900172
          supporting_text: Type I, II, III, IV, V, and VI collagens serve as 
            extracellular ligands for the isoforms of platelet-derived growth 
            factor (AA, BB, and AB).
  - term:
      id: GO:0014910
      label: regulation of smooth muscle cell migration
    evidence_type: IDA
    original_reference_id: PMID:9409235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9409235
          supporting_text: Platelet-derived growth factor beta-receptors can 
            both promote and inhibit chemotaxis in human vascular smooth muscle 
            cells.
  - term:
      id: GO:0050919
      label: negative chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:9409235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9409235
          supporting_text: Platelet-derived growth factor beta-receptors can 
            both promote and inhibit chemotaxis in human vascular smooth muscle 
            cells.
  - term:
      id: GO:0001775
      label: cell activation
    evidence_type: TAS
    original_reference_id: PMID:10508235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10508235
          supporting_text: Mechanism of action and in vivo role of 
            platelet-derived growth factor.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IPI
    original_reference_id: PMID:2536956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2536956
          supporting_text: Isolation of a novel receptor cDNA establishes the 
            existence of two PDGF receptor genes.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:17470632
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17470632
          supporting_text: Apr 30. Vascular endothelial growth factor can signal
            through platelet-derived growth factor receptors.
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IDA
    original_reference_id: PMID:17470632
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17470632
          supporting_text: Apr 30. Vascular endothelial growth factor can signal
            through platelet-derived growth factor receptors.
  - term:
      id: GO:0032956
      label: regulation of actin cytoskeleton organization
    evidence_type: TAS
    original_reference_id: PMID:10508235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10508235
          supporting_text: Mechanism of action and in vivo role of 
            platelet-derived growth factor.
  - term:
      id: GO:0042060
      label: wound healing
    evidence_type: TAS
    original_reference_id: PMID:10508235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10508235
          supporting_text: Mechanism of action and in vivo role of 
            platelet-derived growth factor.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2536956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2536956
          supporting_text: Isolation of a novel receptor cDNA establishes the 
            existence of two PDGF receptor genes.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:10806482
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10806482
          supporting_text: PDGF-C is a new protease-activated ligand for the 
            PDGF alpha-receptor.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:3754619
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:3754619
          supporting_text: cDNA sequence and chromosomal localization of human 
            platelet-derived growth factor A-chain and its expression in tumour 
            cell lines.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:7073684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
  - term:
      id: GO:0009611
      label: response to wounding
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of 
            platelet-derived growth factor leading to inhibition of P43 and P20 
            phosphorylation.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:291037
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:291037
          supporting_text: 'Platelet-derived growth factor: purification and partial
            characterization.'
  - term:
      id: GO:0010512
      label: negative regulation of phosphatidylinositol biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of 
            platelet-derived growth factor leading to inhibition of P43 and P20 
            phosphorylation.
  - term:
      id: GO:0010544
      label: negative regulation of platelet activation
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of 
            platelet-derived growth factor leading to inhibition of P43 and P20 
            phosphorylation.
  - term:
      id: GO:0042803
      label: protein homodimerization activity
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0042803
      label: protein homodimerization activity
    evidence_type: IDA
    original_reference_id: PMID:3754619
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:3754619
          supporting_text: cDNA sequence and chromosomal localization of human 
            platelet-derived growth factor A-chain and its expression in tumour 
            cell lines.
  - term:
      id: GO:0046982
      label: protein heterodimerization activity
    evidence_type: IPI
    original_reference_id: PMID:7073684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human 
            osteosarcoma cells but does not stimulate cell replication.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human 
            osteosarcoma cells but does not stimulate cell replication.
  - term:
      id: GO:0048407
      label: platelet-derived growth factor binding
    evidence_type: IPI
    original_reference_id: PMID:7073684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:16462734
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16462734
          supporting_text: VEGF-C is a trophic factor for neural progenitors in 
            the vertebrate embryonic brain.
  - term:
      id: GO:0007267
      label: cell-cell signaling
    evidence_type: TAS
    original_reference_id: PMID:2842868
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2842868
          supporting_text: Comparison of biological properties and transforming 
            potential of human PDGF-A and PDGF-B chains.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10508235
    title: Mechanism of action and in vivo role of platelet-derived growth 
      factor.
    findings: []
  - id: PMID:10806482
    title: PDGF-C is a new protease-activated ligand for the PDGF 
      alpha-receptor.
    findings: []
  - id: PMID:11297552
    title: Platelet-derived growth factor C (PDGF-C), a novel growth factor that
      binds to PDGF alpha and beta receptor.
    findings: []
  - id: PMID:11788434
    title: Effect of platelet-derived growth factor isoforms in rat metanephric 
      mesenchymal cells.
    findings: []
  - id: PMID:12070119
    title: Adipocyte-derived plasma protein adiponectin acts as a 
      platelet-derived growth factor-BB-binding protein and regulates growth 
      factor-induced common postreceptor signal in vascular smooth muscle cell.
    findings: []
  - id: PMID:16462734
    title: VEGF-C is a trophic factor for neural progenitors in the vertebrate 
      embryonic brain.
    findings: []
  - id: PMID:17470632
    title: Vascular endothelial growth factor can signal through 
      platelet-derived growth factor receptors.
    findings: []
  - id: PMID:19019919
    title: PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis 
      induced by PDGF AA.
    findings: []
  - id: PMID:2439522
    title: PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells 
      but does not stimulate cell replication.
    findings: []
  - id: PMID:25241761
    title: Using an in situ proximity ligation assay to systematically profile 
      endogenous protein-protein interactions in a pathway network.
    findings: []
  - id: PMID:2536956
    title: Isolation of a novel receptor cDNA establishes the existence of two 
      PDGF receptor genes.
    findings: []
  - id: PMID:2538439
    title: Collagen-induced binding to human platelets of platelet-derived 
      growth factor leading to inhibition of P43 and P20 phosphorylation.
    findings: []
  - id: PMID:2836953
    title: A common PDGF receptor is activated by homodimeric A and B forms of 
      PDGF.
    findings: []
  - id: PMID:2842868
    title: Comparison of biological properties and transforming potential of 
      human PDGF-A and PDGF-B chains.
    findings: []
  - id: PMID:291037
    title: 'Platelet-derived growth factor: purification and partial characterization.'
    findings: []
  - id: PMID:3754619
    title: cDNA sequence and chromosomal localization of human platelet-derived 
      growth factor A-chain and its expression in tumour cell lines.
    findings: []
  - id: PMID:7073684
    title: 'Platelet-derived growth factor: identification of constituent polypeptide
      chains.'
    findings: []
  - id: PMID:7679113
    title: Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB 
      binding to alpha and beta PDGF receptor.
    findings: []
  - id: PMID:8900172
    title: Type I, II, III, IV, V, and VI collagens serve as extracellular 
      ligands for the isoforms of platelet-derived growth factor (AA, BB, and 
      AB).
    findings: []
  - id: PMID:9409235
    title: Platelet-derived growth factor beta-receptors can both promote and 
      inhibit chemotaxis in human vascular smooth muscle cells.
    findings: []
  - id: Reactome:R-HSA-1524182
    title: Activated PLC gamma dissociates from the PDGF receptor
    findings: []
  - id: Reactome:R-HSA-1524186
    title: Phosphorylation of PLCgamma by PDGFR
    findings: []
  - id: Reactome:R-HSA-186765
    title: PLC-gamma binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186773
    title: PDGF dimer binds two receptors simultaneously
    findings: []
  - id: Reactome:R-HSA-186778
    title: SHP2 binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186780
    title: PI3-kinase binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186785
    title: PDGF-AA clevage by Furin
    findings: []
  - id: Reactome:R-HSA-186800
    title: PI3K catalyses the phosphorylation of PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-186819
    title: SH2 domain of Src binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186826
    title: GRB2:SOS1 complex binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186834
    title: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
    findings: []
  - id: Reactome:R-HSA-2316434
    title: PI3K phosphorylates PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-2396337
    title: HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, 
      PDGFA homodimer, PDGFB homodimer
    findings: []
  - id: Reactome:R-HSA-2400009
    title: PI3K inhibitors block PI3K catalytic activity
    findings: []
  - id: Reactome:R-HSA-380780
    title: 'TODO: Fetch title'
    findings: []
  - id: Reactome:R-HSA-380782
    title: STAT binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-382052
    title: p130Cas and C3G bind PDGFR bound Crk
    findings: []
  - id: Reactome:R-HSA-382053
    title: 'TODO: Fetch title'
    findings: []
  - id: Reactome:R-HSA-382054
    title: PDGF binds to extracellular matrix proteins
    findings: []
  - id: Reactome:R-HSA-382055
    title: Grb7 binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-382056
    title: Crk binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-382058
    title: Nck binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-389083
    title: Autophosphorylation of PDGF alpha receptors
    findings: []
  - id: Reactome:R-HSA-389086
    title: Autophosphorylation of PDGF alpha/beta receptors
    findings: []
  - id: Reactome:R-HSA-481007
    title: Exocytosis of platelet alpha granule contents
    findings: []
  - id: Reactome:R-HSA-5672965
    title: RAS GEFs promote RAS nucleotide exchange
    findings: []
  - id: Reactome:R-HSA-8864036
    title: PTPN12 dephosphorylates PDGFRB at Y1021
    findings: []
  - id: Reactome:R-HSA-8865276
    title: PDGF-AB clevage by Furin
    findings: []
  - id: Reactome:R-HSA-9674093
    title: PDGFRs bind type I TKI
    findings: []
  - id: Reactome:R-HSA-9796072
    title: NFE2L2 dependent PDGFA expression
    findings: []