PDGFB

Existing Annotations Review

Gene Description

Existing Annotations Review

Core Functions

References

Deep Research

Falcon

📚 Additional Documentation

Notes

📄 View Raw YAML

GO Term	Evidence	Action	Reason
GO:0008284 positive regulation of cell population proliferation	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: positive regulation of cell population proliferation is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome. Reason: Broad positive regulation of cell population proliferation is a downstream growth-factor outcome. Keep it as supported but non-core; more specific cell-type proliferation terms and the core ligand/receptor-binding function are more informative.
GO:0030335 positive regulation of cell migration	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: positive regulation of cell migration is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome. Reason: Broad positive regulation of cell migration is a downstream ligand response. Keep it as non-core where supported, while prioritizing cell-type-specific migration/chemotaxis and PDGF receptor signaling terms.
GO:0001525 angiogenesis	IBA GO_REF:0000033	ACCEPT	Summary: angiogenesis is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: Angiogenesis is supported through the PDGF-B/PDGFRB endothelial-mural cell axis, especially pericyte recruitment and vessel stabilization.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA GO_REF:0000033	MARK AS OVER ANNOTATED	Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB molecular function and should not be promoted as core for the ligand.
GO:0048008 platelet-derived growth factor receptor signaling pathway	IBA GO_REF:0000033	ACCEPT	Summary: platelet-derived growth factor receptor signaling pathway is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: PDGF receptor signaling pathway is the core biological process initiated by PDGFB ligand binding to PDGFRA/PDGFRB receptor complexes.
GO:0005161 platelet-derived growth factor receptor binding	IBA GO_REF:0000033	ACCEPT	Summary: platelet-derived growth factor receptor binding is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: PDGF receptor binding is a defining molecular function for PDGF-B-containing ligands. PDGF-BB and PDGF-AB bind PDGFRA/PDGFRB receptor dimers extracellularly and initiate PDGF receptor signaling. Supporting Evidence: file:human/PDGFB/PDGFB-deep-research-falcon.md GO MF recommendations (plain-English): “PDGF receptor binding” and “growth factor activity,” with the binding scope emphasizing receptor dimer activation via extracellular ligand, not receptor catalytic activity (fredriksson2004thepdgffamily pages 5-7, ostman1992pdgfaaandpdgfbb pages 1-2).
GO:0005615 extracellular space	IBA GO_REF:0000033	ACCEPT	Summary: extracellular space is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: Extracellular space is an appropriate localization for the mature secreted PDGF-B-containing ligand.
GO:0070374 positive regulation of ERK1 and ERK2 cascade	IBA GO_REF:0000033	MARK AS OVER ANNOTATED	Summary: positive regulation of ERK1 and ERK2 cascade is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: ERK1/ERK2 cascade activation is downstream of PDGF receptor signaling. It is biologically connected but over-annotated for the PDGFB ligand compared with the PDGF receptor signaling pathway term.
GO:0050918 positive chemotaxis	IEA GO_REF:0000108	ACCEPT	Summary: positive chemotaxis is supported as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process. Reason: Accept. positive chemotaxis is a supported biological process downstream of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
GO:0005576 extracellular region	IEA GO_REF:0000044	ACCEPT	Summary: extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: Extracellular region is strongly supported for mature PDGFB, which is secreted and acts as an extracellular receptor ligand.
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway	IEA GO_REF:0000117	MODIFY	Summary: cell surface receptor protein tyrosine kinase signaling pathway captures a related signaling idea, but the term has the wrong scope or aspect for PDGFB. Reason: The parent receptor tyrosine kinase signaling term is directionally correct but too broad. PDGFB specifically initiates platelet-derived growth factor receptor signaling. Proposed replacements: platelet-derived growth factor receptor signaling pathway
GO:0008083 growth factor activity	IEA GO_REF:0000120	ACCEPT	Summary: growth factor activity is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: Growth factor activity is a core PDGFB function. The mature ligand acts extracellularly as a mitogen/chemoattractant for mesenchymal and vascular mural cell populations.
GO:0010468 regulation of gene expression	IEA GO_REF:0000117	MARK AS OVER ANNOTATED	Summary: regulation of gene expression is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Regulation of gene expression is a broad downstream response to PDGF signaling and should not be treated as a PDGFB core function.
GO:0010557 positive regulation of macromolecule biosynthetic process	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: positive regulation of macromolecule biosynthetic process is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome. Reason: Macromolecule biosynthesis is a broad downstream response to PDGF signaling and is less informative than PDGF receptor signaling or cell-type-specific growth terms.
GO:0014911 positive regulation of smooth muscle cell migration	IEA GO_REF:0000117	ACCEPT	Summary: positive regulation of smooth muscle cell migration is supported as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process. Reason: Accept. smooth muscle cell migration is a supported biological process downstream of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
GO:0016020 membrane	IEA GO_REF:0000002	KEEP AS NON CORE	Summary: membrane is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome. Reason: Membrane is too broad for PDGFB; any membrane association is a precursor/retention or receptor-bound context, so keep only as non-core.
GO:0048018 receptor ligand activity	IEA GO_REF:0000117	ACCEPT	Summary: receptor ligand activity is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: Receptor ligand activity is an appropriate parent-level molecular function for PDGFB because the mature PDGF-B-containing dimer activates cell-surface PDGF receptors.
GO:0048661 positive regulation of smooth muscle cell proliferation	IEA GO_REF:0000117	ACCEPT	Summary: positive regulation of smooth muscle cell proliferation is supported as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process. Reason: Accept. smooth muscle cell proliferation is a supported biological process downstream of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
GO:0051239 regulation of multicellular organismal process	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: regulation of multicellular organismal process is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome. Reason: Regulation of multicellular organismal process is too broad for core PDGFB biology; retain only as a non-core propagated summary of developmental effects.
GO:0051781 positive regulation of cell division	IEA GO_REF:0000043	KEEP AS NON CORE	Summary: positive regulation of cell division is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome. Reason: Positive regulation of cell division is a broad downstream outcome of growth-factor signaling, not a core ligand function.
GO:1902533 positive regulation of intracellular signal transduction	IEA GO_REF:0000117	MARK AS OVER ANNOTATED	Summary: positive regulation of intracellular signal transduction is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Positive regulation of intracellular signal transduction is too broad and downstream for the extracellular PDGFB ligand.
GO:0005515 protein binding	IPI PMID:10806482 PDGF-C is a new protease-activated ligand for the PDGF alpha...	MARK AS OVER ANNOTATED	Summary: protein binding is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix retention should be used instead. Supporting Evidence: PMID:10806482 PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
GO:0005515 protein binding	IPI PMID:11297552 Platelet-derived growth factor C (PDGF-C), a novel growth fa...	MARK AS OVER ANNOTATED	Summary: protein binding is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix retention should be used instead. Supporting Evidence: PMID:11297552 2001 Apr 10. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
GO:0005515 protein binding	IPI PMID:17981115 Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tum...	MARK AS OVER ANNOTATED	Summary: protein binding is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix retention should be used instead. Supporting Evidence: PMID:17981115 Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
GO:0005515 protein binding	IPI PMID:20534510 Structures of a platelet-derived growth factor/propeptide co...	MARK AS OVER ANNOTATED	Summary: protein binding is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix retention should be used instead. Supporting Evidence: PMID:20534510 Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
GO:0005515 protein binding	IPI PMID:32296183 A reference map of the human binary protein interactome.	MARK AS OVER ANNOTATED	Summary: protein binding is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix retention should be used instead. Supporting Evidence: PMID:32296183 Apr 8. A reference map of the human binary protein interactome.
GO:0005515 protein binding	IPI PMID:7679113 Mechanism of platelet-derived growth factor (PDGF) AA, AB, a...	MARK AS OVER ANNOTATED	Summary: protein binding is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix retention should be used instead. Supporting Evidence: PMID:7679113 Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
GO:0042802 identical protein binding	IPI PMID:1396586 Crystal structure of human platelet-derived growth factor BB...	ACCEPT	Summary: identical protein binding is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: PDGFB forms the disulfide-linked PDGF-BB homodimer; identical protein binding captures that ligand-dimer assembly when supported by PDGF-BB structural or receptor-binding evidence. Supporting Evidence: PMID:1396586 Crystal structure of human platelet-derived growth factor BB.
GO:0042802 identical protein binding	IPI PMID:23139410 Unique motifs and hydrophobic interactions shape the binding...	REMOVE	Summary: PMID:23139410 is a modified DNA aptamer/SOMAmer structure with PDGF-BB as the target, not direct evidence for PDGFB-PDGFB identical protein binding. Reason: Remove this specific GOA evidence row because the publication supports DNA aptamer binding to PDGF-BB rather than PDGFB self-association. The same GO term remains supported by PMID:1396586 and PMID:7679113. Supporting Evidence: PMID:23139410 Here we report a unique crystal structure of a SOMAmer bound to its target, platelet-derived growth factor B (PDGF-BB).
GO:0042802 identical protein binding	IPI PMID:7679113 Mechanism of platelet-derived growth factor (PDGF) AA, AB, a...	ACCEPT	Summary: identical protein binding is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: PDGFB forms the disulfide-linked PDGF-BB homodimer; identical protein binding captures that ligand-dimer assembly when supported by PDGF-BB structural or receptor-binding evidence. Supporting Evidence: PMID:7679113 Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
GO:0036120 cellular response to platelet-derived growth factor stimulus	IDA PMID:9685360 Apolipoprotein E inhibits platelet-derived growth factor-ind...	MARK AS OVER ANNOTATED	Summary: cellular response to platelet-derived growth factor stimulus is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Cellular response to platelet-derived growth factor stimulus describes responding cells; PDGFB is the ligand stimulus, so this is over-annotated for the gene product. Supporting Evidence: PMID:9685360 Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase.
GO:0043410 positive regulation of MAPK cascade	IDA PMID:9685360 Apolipoprotein E inhibits platelet-derived growth factor-ind...	MARK AS OVER ANNOTATED	Summary: positive regulation of MAPK cascade is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: MAPK cascade activation is downstream of receptor signaling and is less appropriate for PDGFB than PDGF receptor signaling pathway. Supporting Evidence: PMID:9685360 Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase.
GO:0048008 platelet-derived growth factor receptor signaling pathway	IDA PMID:9685360 Apolipoprotein E inhibits platelet-derived growth factor-ind...	ACCEPT	Summary: platelet-derived growth factor receptor signaling pathway is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: PDGF receptor signaling pathway is the core biological process initiated by PDGFB ligand binding to PDGFRA/PDGFRB receptor complexes. Supporting Evidence: PMID:9685360 Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase.
GO:0014805 smooth muscle adaptation	NAS PMID:16477012 Synergistic roles of platelet-derived growth factor-BB and i...	KEEP AS NON CORE	Summary: smooth muscle adaptation is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome. Reason: Smooth muscle adaptation is a vascular smooth muscle phenotype downstream of PDGF signaling and should remain non-core. Supporting Evidence: PMID:16477012 Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.
GO:0048008 platelet-derived growth factor receptor signaling pathway	IDA PMID:16477012 Synergistic roles of platelet-derived growth factor-BB and i...	ACCEPT	Summary: platelet-derived growth factor receptor signaling pathway is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: PDGF receptor signaling pathway is the core biological process initiated by PDGFB ligand binding to PDGFRA/PDGFRB receptor complexes. Supporting Evidence: PMID:16477012 Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA PMID:16477012 Synergistic roles of platelet-derived growth factor-BB and i...	MARK AS OVER ANNOTATED	Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB molecular function and should not be promoted as core for the ligand. Supporting Evidence: PMID:16477012 Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.
GO:0048008 platelet-derived growth factor receptor signaling pathway	NAS PMID:7679113 Mechanism of platelet-derived growth factor (PDGF) AA, AB, a...	ACCEPT	Summary: platelet-derived growth factor receptor signaling pathway is supported for PDGFB in the context of its mature extracellular PDGF ligand function. Reason: PDGF receptor signaling pathway is the core biological process initiated by PDGFB ligand binding to PDGFRA/PDGFRB receptor complexes. Supporting Evidence: PMID:7679113 Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
GO:0035556 intracellular signal transduction	IMP PMID:24008408 CAP37 activation of PKC promotes human corneal epithelial ce...	MARK AS OVER ANNOTATED	Summary: intracellular signal transduction is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Intracellular signal transduction is a downstream cellular response and not an activity or localization of the secreted PDGFB ligand. Supporting Evidence: PMID:24008408 CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis.
GO:0008284 positive regulation of cell population proliferation	IDA PMID:16530387 c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-ind...	KEEP AS NON CORE	Summary: positive regulation of cell population proliferation is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome. Reason: Broad positive regulation of cell population proliferation is a downstream growth-factor outcome. Keep it as supported but non-core; more specific cell-type proliferation terms and the core ligand/receptor-binding function are more informative. Supporting Evidence: PMID:16530387 c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells.
GO:0010467 gene expression	IDA PMID:16530387 c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-ind...	MARK AS OVER ANNOTATED	Summary: gene expression is biologically connected to PDGFB signaling but overstates the direct function of the secreted ligand. Reason: Gene expression is a downstream cellular response and is over-annotated for the PDGFB ligand. Supporting Evidence: PMID:16530387 c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells.