PDGFB

id: P01127
gene_symbol: PDGFB
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for PDGFB'
existing_annotations:
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050918
      label: positive chemotaxis
    evidence_type: IEA
    original_reference_id: GO_REF:0000108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007169
      label: cell surface receptor protein tyrosine kinase signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010468
      label: regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010557
      label: positive regulation of macromolecule biosynthetic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014911
      label: positive regulation of smooth muscle cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048661
      label: positive regulation of smooth muscle cell proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051239
      label: regulation of multicellular organismal process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051781
      label: positive regulation of cell division
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902533
      label: positive regulation of intracellular signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10806482
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10806482
          supporting_text: PDGF-C is a new protease-activated ligand for the 
            PDGF alpha-receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11297552
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11297552
          supporting_text: 2001 Apr 10. Platelet-derived growth factor C 
            (PDGF-C), a novel growth factor that binds to PDGF alpha and beta 
            receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17981115
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17981115
          supporting_text: Anti-PlGF inhibits growth of 
            VEGF(R)-inhibitor-resistant tumors without affecting healthy 
            vessels.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20534510
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20534510
          supporting_text: Structures of a platelet-derived growth 
            factor/propeptide complex and a platelet-derived growth 
            factor/receptor complex.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7679113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) 
            AA, AB, and BB binding to alpha and beta PDGF receptor.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:1396586
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:1396586
          supporting_text: Crystal structure of human platelet-derived growth 
            factor BB.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:23139410
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23139410
          supporting_text: Unique motifs and hydrophobic interactions shape the 
            binding of modified DNA ligands to protein targets.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:7679113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) 
            AA, AB, and BB binding to alpha and beta PDGF receptor.
  - term:
      id: GO:0036120
      label: cellular response to platelet-derived growth factor stimulus
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth 
            factor-induced vascular smooth muscle cell migration and 
            proliferation by suppressing signal transduction and preventing cell
            entry to G1 phase.
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth 
            factor-induced vascular smooth muscle cell migration and 
            proliferation by suppressing signal transduction and preventing cell
            entry to G1 phase.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth 
            factor-induced vascular smooth muscle cell migration and 
            proliferation by suppressing signal transduction and preventing cell
            entry to G1 phase.
  - term:
      id: GO:0014805
      label: smooth muscle adaptation
    evidence_type: NAS
    original_reference_id: PMID:16477012
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16477012
          supporting_text: Synergistic roles of platelet-derived growth 
            factor-BB and interleukin-1beta in phenotypic modulation of human 
            aortic smooth muscle cells.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:16477012
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16477012
          supporting_text: Synergistic roles of platelet-derived growth 
            factor-BB and interleukin-1beta in phenotypic modulation of human 
            aortic smooth muscle cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:16477012
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16477012
          supporting_text: Synergistic roles of platelet-derived growth 
            factor-BB and interleukin-1beta in phenotypic modulation of human 
            aortic smooth muscle cells.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: NAS
    original_reference_id: PMID:7679113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) 
            AA, AB, and BB binding to alpha and beta PDGF receptor.
  - term:
      id: GO:0035556
      label: intracellular signal transduction
    evidence_type: IMP
    original_reference_id: PMID:24008408
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24008408
          supporting_text: CAP37 activation of PKC promotes human corneal 
            epithelial cell chemotaxis.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to 
            PDGF-induced DNA synthesis in mesangial cells.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to 
            PDGF-induced DNA synthesis in mesangial cells.
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to 
            PDGF-induced DNA synthesis in mesangial cells.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to 
            PDGF-induced DNA synthesis in mesangial cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to 
            PDGF-induced DNA synthesis in mesangial cells.
  - term:
      id: GO:1904707
      label: positive regulation of vascular associated smooth muscle cell 
        proliferation
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived
            growth factor signaling is critical for modulation of vascular 
            smooth muscle phenotype.
  - term:
      id: GO:1905064
      label: negative regulation of vascular associated smooth muscle cell 
        differentiation
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived
            growth factor signaling is critical for modulation of vascular 
            smooth muscle phenotype.
  - term:
      id: GO:1905176
      label: positive regulation of vascular associated smooth muscle cell 
        dedifferentiation
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived
            growth factor signaling is critical for modulation of vascular 
            smooth muscle phenotype.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: EXP
    original_reference_id: PMID:20534510
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20534510
          supporting_text: Structures of a platelet-derived growth 
            factor/propeptide complex and a platelet-derived growth 
            factor/receptor complex.
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036120
      label: cellular response to platelet-derived growth factor stimulus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048661
      label: positive regulation of smooth muscle cell proliferation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human 
            vascular smooth muscle cells and inhibits PDGF-BB-induced cell 
            proliferation and migration through targeting orphan nuclear 
            receptor NOR1.
  - term:
      id: GO:1902894
      label: negative regulation of miRNA transcription
    evidence_type: IDA
    original_reference_id: PMID:26493107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26493107
          supporting_text: Epub 2015 Oct 19. miRNA-34a reduces neointima 
            formation through inhibiting smooth muscle cell proliferation and 
            migration.
  - term:
      id: GO:1902895
      label: positive regulation of miRNA transcription
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived
            growth factor signaling is critical for modulation of vascular 
            smooth muscle phenotype.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:19126672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19126672
          supporting_text: Jan 6. Spontaneous phosphoinositide 3-kinase 
            signaling dynamics drive spreading and random migration of 
            fibroblasts.
  - term:
      id: GO:0010811
      label: positive regulation of cell-substrate adhesion
    evidence_type: IDA
    original_reference_id: PMID:19126672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19126672
          supporting_text: Jan 6. Spontaneous phosphoinositide 3-kinase 
            signaling dynamics drive spreading and random migration of 
            fibroblasts.
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human 
            vascular smooth muscle cells and inhibits PDGF-BB-induced cell 
            proliferation and migration through targeting orphan nuclear 
            receptor NOR1.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human 
            vascular smooth muscle cells and inhibits PDGF-BB-induced cell 
            proliferation and migration through targeting orphan nuclear 
            receptor NOR1.
  - term:
      id: GO:1904707
      label: positive regulation of vascular associated smooth muscle cell 
        proliferation
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human 
            vascular smooth muscle cells and inhibits PDGF-BB-induced cell 
            proliferation and migration through targeting orphan nuclear 
            receptor NOR1.
  - term:
      id: GO:1904754
      label: positive regulation of vascular associated smooth muscle cell 
        migration
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human 
            vascular smooth muscle cells and inhibits PDGF-BB-induced cell 
            proliferation and migration through targeting orphan nuclear 
            receptor NOR1.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human 
            osteosarcoma cells but does not stimulate cell replication.
  - term:
      id: GO:0031012
      label: extracellular matrix
    evidence_type: HDA
    original_reference_id: PMID:23979707
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23979707
          supporting_text: Epub 2013 Aug 26. SILAC-based proteomics of human 
            primary endothelial cell morphogenesis unveils tumor angiogenic 
            markers.
  - term:
      id: GO:1904707
      label: positive regulation of vascular associated smooth muscle cell 
        proliferation
    evidence_type: IDA
    original_reference_id: PMID:12070119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as 
            a platelet-derived growth factor-BB-binding protein and regulates 
            growth factor-induced common postreceptor signal in vascular smooth 
            muscle cell.
  - term:
      id: GO:1904754
      label: positive regulation of vascular associated smooth muscle cell 
        migration
    evidence_type: IDA
    original_reference_id: PMID:12070119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as 
            a platelet-derived growth factor-BB-binding protein and regulates 
            growth factor-induced common postreceptor signal in vascular smooth 
            muscle cell.
  - term:
      id: GO:0048661
      label: positive regulation of smooth muscle cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:21321938
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21321938
          supporting_text: Interleukin-18/WNT1-inducible signaling pathway 
            protein-1 signaling mediates human saphenous vein smooth muscle cell
            proliferation.
  - term:
      id: GO:0035655
      label: interleukin-18-mediated signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:21321938
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21321938
          supporting_text: Interleukin-18/WNT1-inducible signaling pathway 
            protein-1 signaling mediates human saphenous vein smooth muscle cell
            proliferation.
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:25089138
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25089138
          supporting_text: 2014 Jul 25. miR-18a-5p MicroRNA Increases Vascular 
            Smooth Muscle Cell Differentiation by Downregulating Syndecan4.
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:25089138
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25089138
          supporting_text: 2014 Jul 25. miR-18a-5p MicroRNA Increases Vascular 
            Smooth Muscle Cell Differentiation by Downregulating Syndecan4.
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865275
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1524182
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1524186
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186765
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186773
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186778
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186780
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186786
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186798
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186800
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186819
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186826
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186834
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2316434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2396337
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2400009
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-380780
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-380782
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382054
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382055
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382056
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389083
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389086
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-481007
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5672965
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8864036
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865275
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9674093
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived
            growth factor signaling is critical for modulation of vascular 
            smooth muscle phenotype.
  - term:
      id: GO:1904754
      label: positive regulation of vascular associated smooth muscle cell 
        migration
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived
            growth factor signaling is critical for modulation of vascular 
            smooth muscle phenotype.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human 
            osteosarcoma cells but does not stimulate cell replication.
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IDA
    original_reference_id: PMID:12070119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as 
            a platelet-derived growth factor-BB-binding protein and regulates 
            growth factor-induced common postreceptor signal in vascular smooth 
            muscle cell.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of 
            platelet-derived growth factor leading to inhibition of P43 and P20 
            phosphorylation.
  - term:
      id: GO:0005788
      label: endoplasmic reticulum lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865275
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031093
      label: platelet alpha granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-481007
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas 
            tyrosine phosphorylation is essential for growth factor-dependent 
            migration of glioma and endothelial cells.
  - term:
      id: GO:0042056
      label: chemoattractant activity
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas 
            tyrosine phosphorylation is essential for growth factor-dependent 
            migration of glioma and endothelial cells.
  - term:
      id: GO:0071363
      label: cellular response to growth factor stimulus
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas 
            tyrosine phosphorylation is essential for growth factor-dependent 
            migration of glioma and endothelial cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:2536956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2536956
          supporting_text: Isolation of a novel receptor cDNA establishes the 
            existence of two PDGF receptor genes.
  - term:
      id: GO:1900127
      label: positive regulation of hyaluronan biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:17324121
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17324121
          supporting_text: 'Growth factor regulation of hyaluronan synthesis and degradation
            in human dermal fibroblasts: importance of hyaluronan for the mitogenic
            response of PDGF-BB.'
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:17324121
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17324121
          supporting_text: 'Growth factor regulation of hyaluronan synthesis and degradation
            in human dermal fibroblasts: importance of hyaluronan for the mitogenic
            response of PDGF-BB.'
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:17324121
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17324121
          supporting_text: 'Growth factor regulation of hyaluronan synthesis and degradation
            in human dermal fibroblasts: importance of hyaluronan for the mitogenic
            response of PDGF-BB.'
  - term:
      id: GO:0030097
      label: hemopoiesis
    evidence_type: IMP
    original_reference_id: PMID:11264163
    negated: true
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11264163
          supporting_text: Basis of hematopoietic defects in platelet-derived 
            growth factor (PDGF)-B and PDGF beta-receptor null mice.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas 
            tyrosine phosphorylation is essential for growth factor-dependent 
            migration of glioma and endothelial cells.
  - term:
      id: GO:0060326
      label: cell chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas 
            tyrosine phosphorylation is essential for growth factor-dependent 
            migration of glioma and endothelial cells.
  - term:
      id: GO:0035793
      label: positive regulation of metanephric mesenchymal cell migration by 
        platelet-derived growth factor receptor-beta signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:10644978
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10644978
          supporting_text: PSM, a mediator of PDGF-BB-, IGF-I-, and 
            insulin-stimulated mitogenesis.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta 
            regulates migration and DNA synthesis in metanephric mesenchymal 
            cells.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived
            growth factor beta in metanephric mesenchymal cells.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
  - term:
      id: GO:2000591
      label: positive regulation of metanephric mesenchymal cell migration
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta 
            regulates migration and DNA synthesis in metanephric mesenchymal 
            cells.
  - term:
      id: GO:0016323
      label: basolateral plasma membrane
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: IDA
    original_reference_id: PMID:10644978
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10644978
          supporting_text: PSM, a mediator of PDGF-BB-, IGF-I-, and 
            insulin-stimulated mitogenesis.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:10644978
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10644978
          supporting_text: PSM, a mediator of PDGF-BB-, IGF-I-, and 
            insulin-stimulated mitogenesis.
  - term:
      id: GO:0060326
      label: cell chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:16014047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16014047
          supporting_text: Hypoxia regulates PDGF-B interactions between 
            glomerular capillary endothelial and mesangial cells.
  - term:
      id: GO:0060326
      label: cell chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:17991872
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17991872
          supporting_text: 'TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced
            chemotaxis in different cell types: involvement of Src and PLC.'
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to 
            PDGF-induced DNA synthesis in mesangial cells.
  - term:
      id: GO:0072126
      label: positive regulation of glomerular mesangial cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:16014047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16014047
          supporting_text: Hypoxia regulates PDGF-B interactions between 
            glomerular capillary endothelial and mesangial cells.
  - term:
      id: GO:0018108
      label: peptidyl-tyrosine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: >-
        OVER-ANNOTATION: PDGFB is a secreted LIGAND for PDGF receptors. It has NO
        kinase
        activity. PDGFB binding triggers receptor tyrosine kinase activation and downstream
        phosphorylation cascades, but PDGFB itself doesn't catalyze phosphorylation.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta 
            regulates migration and DNA synthesis in metanephric mesenchymal 
            cells.
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0043406
      label: positive regulation of MAP kinase activity
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IMP
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta 
            regulates migration and DNA synthesis in metanephric mesenchymal 
            cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta 
            regulates migration and DNA synthesis in metanephric mesenchymal 
            cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived
            growth factor beta in metanephric mesenchymal cells.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0072126
      label: positive regulation of glomerular mesangial cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in 
            rat metanephric mesenchymal cells.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: >-
        OVER-ANNOTATION: PDGFB is a secreted LIGAND, not a kinase. It triggers phosphorylation
        by activating PDGF receptor tyrosine kinases but doesn't catalyze phosphorylation
        itself.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived
            growth factor beta in metanephric mesenchymal cells.
  - term:
      id: GO:0016176
      label: superoxide-generating NADPH oxidase activator activity
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived
            growth factor beta in metanephric mesenchymal cells.
  - term:
      id: GO:0043406
      label: positive regulation of MAP kinase activity
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived
            growth factor beta in metanephric mesenchymal cells.
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived
            growth factor beta in metanephric mesenchymal cells.
  - term:
      id: GO:0050921
      label: positive regulation of chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived
            growth factor beta in metanephric mesenchymal cells.
  - term:
      id: GO:0072593
      label: reactive oxygen species metabolic process
    evidence_type: IMP
    original_reference_id: PMID:17942966
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived
            growth factor beta in metanephric mesenchymal cells.
  - term:
      id: GO:0090280
      label: positive regulation of calcium ion import
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
  - term:
      id: GO:2000379
      label: positive regulation of reactive oxygen species metabolic process
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
  - term:
      id: GO:0001892
      label: embryonic placenta development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003104
      label: positive regulation of glomerular filtration
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007507
      label: heart development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038001
      label: paracrine signaling
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072255
      label: metanephric glomerular mesangial cell development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12070119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as 
            a platelet-derived growth factor-BB-binding protein and regulates 
            growth factor-induced common postreceptor signal in vascular smooth 
            muscle cell.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071506
      label: cellular response to mycophenolic acid
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002548
      label: monocyte chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:17991872
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17991872
          supporting_text: 'TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced
            chemotaxis in different cell types: involvement of Src and PLC.'
  - term:
      id: GO:0005518
      label: collagen binding
    evidence_type: IDA
    original_reference_id: PMID:8900172
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8900172
          supporting_text: Type I, II, III, IV, V, and VI collagens serve as 
            extracellular ligands for the isoforms of platelet-derived growth 
            factor (AA, BB, and AB).
  - term:
      id: GO:0014911
      label: positive regulation of smooth muscle cell migration
    evidence_type: IDA
    original_reference_id: PMID:9409235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9409235
          supporting_text: Platelet-derived growth factor beta-receptors can 
            both promote and inhibit chemotaxis in human vascular smooth muscle 
            cells.
  - term:
      id: GO:0050921
      label: positive regulation of chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:9409235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9409235
          supporting_text: Platelet-derived growth factor beta-receptors can 
            both promote and inhibit chemotaxis in human vascular smooth muscle 
            cells.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IPI
    original_reference_id: PMID:2536956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2536956
          supporting_text: Isolation of a novel receptor cDNA establishes the 
            existence of two PDGF receptor genes.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2536956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2536956
          supporting_text: Isolation of a novel receptor cDNA establishes the 
            existence of two PDGF receptor genes.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:7073684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
  - term:
      id: GO:0009611
      label: response to wounding
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of 
            platelet-derived growth factor leading to inhibition of P43 and P20 
            phosphorylation.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:291037
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:291037
          supporting_text: 'Platelet-derived growth factor: purification and partial
            characterization.'
  - term:
      id: GO:0010512
      label: negative regulation of phosphatidylinositol biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of 
            platelet-derived growth factor leading to inhibition of P43 and P20 
            phosphorylation.
  - term:
      id: GO:0010544
      label: negative regulation of platelet activation
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of 
            platelet-derived growth factor leading to inhibition of P43 and P20 
            phosphorylation.
  - term:
      id: GO:0042803
      label: protein homodimerization activity
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0046982
      label: protein heterodimerization activity
    evidence_type: IPI
    original_reference_id: PMID:7073684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human 
            osteosarcoma cells but does not stimulate cell replication.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A 
            and B forms of PDGF.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human 
            osteosarcoma cells but does not stimulate cell replication.
  - term:
      id: GO:0048407
      label: platelet-derived growth factor binding
    evidence_type: IPI
    original_reference_id: PMID:7073684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
  - term:
      id: GO:0001938
      label: positive regulation of endothelial cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth 
            factor-induced vascular smooth muscle cell migration and 
            proliferation by suppressing signal transduction and preventing cell
            entry to G1 phase.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth 
            factor-induced vascular smooth muscle cell migration and 
            proliferation by suppressing signal transduction and preventing cell
            entry to G1 phase.
  - term:
      id: GO:0043536
      label: positive regulation of blood vessel endothelial cell migration
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth 
            factor-induced vascular smooth muscle cell migration and 
            proliferation by suppressing signal transduction and preventing cell
            entry to G1 phase.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: NAS
    original_reference_id: PMID:1661670
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:1661670
          supporting_text: Two PDGF-B chain residues, arginine 27 and isoleucine
            30, mediate receptor binding and activation.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: NAS
    original_reference_id: PMID:1661670
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:1661670
          supporting_text: Two PDGF-B chain residues, arginine 27 and isoleucine
            30, mediate receptor binding and activation.
  - term:
      id: GO:0009611
      label: response to wounding
    evidence_type: NAS
    original_reference_id: PMID:1661670
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:1661670
          supporting_text: Two PDGF-B chain residues, arginine 27 and isoleucine
            30, mediate receptor binding and activation.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000108
    title: Automatic assignment of GO terms using logical inference, based on on
      inter-ontology links
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10644978
    title: PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated 
      mitogenesis.
    findings: []
  - id: PMID:10734101
    title: Platelet-derived growth factor receptor beta regulates migration and 
      DNA synthesis in metanephric mesenchymal cells.
    findings: []
  - id: PMID:10806482
    title: PDGF-C is a new protease-activated ligand for the PDGF 
      alpha-receptor.
    findings: []
  - id: PMID:11264163
    title: Basis of hematopoietic defects in platelet-derived growth factor 
      (PDGF)-B and PDGF beta-receptor null mice.
    findings: []
  - id: PMID:11297552
    title: Platelet-derived growth factor C (PDGF-C), a novel growth factor that
      binds to PDGF alpha and beta receptor.
    findings: []
  - id: PMID:11788434
    title: Effect of platelet-derived growth factor isoforms in rat metanephric 
      mesenchymal cells.
    findings: []
  - id: PMID:12070119
    title: Adipocyte-derived plasma protein adiponectin acts as a 
      platelet-derived growth factor-BB-binding protein and regulates growth 
      factor-induced common postreceptor signal in vascular smooth muscle cell.
    findings: []
  - id: PMID:1396586
    title: Crystal structure of human platelet-derived growth factor BB.
    findings: []
  - id: PMID:16014047
    title: Hypoxia regulates PDGF-B interactions between glomerular capillary 
      endothelial and mesangial cells.
    findings: []
  - id: PMID:16477012
    title: Synergistic roles of platelet-derived growth factor-BB and 
      interleukin-1beta in phenotypic modulation of human aortic smooth muscle 
      cells.
    findings: []
  - id: PMID:16530387
    title: c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA 
      synthesis in mesangial cells.
    findings: []
  - id: PMID:1661670
    title: Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate 
      receptor binding and activation.
    findings: []
  - id: PMID:17324121
    title: 'Growth factor regulation of hyaluronan synthesis and degradation in human
      dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.'
    findings: []
  - id: PMID:17942966
    title: Mitogenic signaling via platelet-derived growth factor beta in 
      metanephric mesenchymal cells.
    findings: []
  - id: PMID:17981115
    title: Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors 
      without affecting healthy vessels.
    findings: []
  - id: PMID:17991872
    title: 'TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis
      in different cell types: involvement of Src and PLC.'
    findings: []
  - id: PMID:19019919
    title: PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis 
      induced by PDGF AA.
    findings: []
  - id: PMID:19088079
    title: Induction of microRNA-221 by platelet-derived growth factor signaling
      is critical for modulation of vascular smooth muscle phenotype.
    findings: []
  - id: PMID:19126672
    title: Spontaneous phosphoinositide 3-kinase signaling dynamics drive 
      spreading and random migration of fibroblasts.
    findings: []
  - id: PMID:20534510
    title: Structures of a platelet-derived growth factor/propeptide complex and
      a platelet-derived growth factor/receptor complex.
    findings: []
  - id: PMID:21245381
    title: Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is 
      essential for growth factor-dependent migration of glioma and endothelial 
      cells.
    findings: []
  - id: PMID:21321938
    title: Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling 
      mediates human saphenous vein smooth muscle cell proliferation.
    findings: []
  - id: PMID:23139410
    title: Unique motifs and hydrophobic interactions shape the binding of 
      modified DNA ligands to protein targets.
    findings: []
  - id: PMID:23554459
    title: MicroRNA-638 is highly expressed in human vascular smooth muscle 
      cells and inhibits PDGF-BB-induced cell proliferation and migration 
      through targeting orphan nuclear receptor NOR1.
    findings: []
  - id: PMID:23979707
    title: SILAC-based proteomics of human primary endothelial cell 
      morphogenesis unveils tumor angiogenic markers.
    findings: []
  - id: PMID:24008408
    title: CAP37 activation of PKC promotes human corneal epithelial cell 
      chemotaxis.
    findings: []
  - id: PMID:2439522
    title: PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells 
      but does not stimulate cell replication.
    findings: []
  - id: PMID:25089138
    title: miR-18a-5p MicroRNA Increases Vascular Smooth Muscle Cell 
      Differentiation by Downregulating Syndecan4.
    findings: []
  - id: PMID:2536956
    title: Isolation of a novel receptor cDNA establishes the existence of two 
      PDGF receptor genes.
    findings: []
  - id: PMID:2538439
    title: Collagen-induced binding to human platelets of platelet-derived 
      growth factor leading to inhibition of P43 and P20 phosphorylation.
    findings: []
  - id: PMID:26493107
    title: miRNA-34a reduces neointima formation through inhibiting smooth 
      muscle cell proliferation and migration.
    findings: []
  - id: PMID:2836953
    title: A common PDGF receptor is activated by homodimeric A and B forms of 
      PDGF.
    findings: []
  - id: PMID:291037
    title: 'Platelet-derived growth factor: purification and partial characterization.'
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:7073684
    title: 'Platelet-derived growth factor: identification of constituent polypeptide
      chains.'
    findings: []
  - id: PMID:7679113
    title: Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB 
      binding to alpha and beta PDGF receptor.
    findings: []
  - id: PMID:8900172
    title: Type I, II, III, IV, V, and VI collagens serve as extracellular 
      ligands for the isoforms of platelet-derived growth factor (AA, BB, and 
      AB).
    findings: []
  - id: PMID:9409235
    title: Platelet-derived growth factor beta-receptors can both promote and 
      inhibit chemotaxis in human vascular smooth muscle cells.
    findings: []
  - id: PMID:9685360
    title: Apolipoprotein E inhibits platelet-derived growth factor-induced 
      vascular smooth muscle cell migration and proliferation by suppressing 
      signal transduction and preventing cell entry to G1 phase.
    findings: []
  - id: Reactome:R-HSA-1524182
    title: Activated PLC gamma dissociates from the PDGF receptor
    findings: []
  - id: Reactome:R-HSA-1524186
    title: Phosphorylation of PLCgamma by PDGFR
    findings: []
  - id: Reactome:R-HSA-186765
    title: PLC-gamma binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186773
    title: PDGF dimer binds two receptors simultaneously
    findings: []
  - id: Reactome:R-HSA-186778
    title: SHP2 binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186780
    title: PI3-kinase binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186786
    title: Autophosphorylation of PDGF beta receptors
    findings: []
  - id: Reactome:R-HSA-186798
    title: GAP binds to PDGF-beta receptors only
    findings: []
  - id: Reactome:R-HSA-186800
    title: PI3K catalyses the phosphorylation of PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-186819
    title: SH2 domain of Src binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186826
    title: GRB2:SOS1 complex binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186834
    title: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
    findings: []
  - id: Reactome:R-HSA-2316434
    title: PI3K phosphorylates PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-2396337
    title: HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, 
      PDGFA homodimer, PDGFB homodimer
    findings: []
  - id: Reactome:R-HSA-2400009
    title: PI3K inhibitors block PI3K catalytic activity
    findings: []
  - id: Reactome:R-HSA-380780
    title: Activation of Src
    findings: []
  - id: Reactome:R-HSA-380782
    title: STAT binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-382052
    title: p130Cas and C3G bind PDGFR bound Crk
    findings: []
  - id: Reactome:R-HSA-382053
    title: Translocation of PDGF from ER to Golgi
    findings: []
  - id: Reactome:R-HSA-382054
    title: PDGF binds to extracellular matrix proteins
    findings: []
  - id: Reactome:R-HSA-382055
    title: Grb7 binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-382056
    title: Crk binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-382058
    title: Nck binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-389083
    title: Autophosphorylation of PDGF alpha receptors
    findings: []
  - id: Reactome:R-HSA-389086
    title: Autophosphorylation of PDGF alpha/beta receptors
    findings: []
  - id: Reactome:R-HSA-481007
    title: Exocytosis of platelet alpha granule contents
    findings: []
  - id: Reactome:R-HSA-5672965
    title: RAS GEFs promote RAS nucleotide exchange
    findings: []
  - id: Reactome:R-HSA-8864036
    title: PTPN12 dephosphorylates PDGFRB at Y1021
    findings: []
  - id: Reactome:R-HSA-8865275
    title: PDGF-BB clevage by Furin
    findings: []
  - id: Reactome:R-HSA-8865276
    title: PDGF-AB clevage by Furin
    findings: []
  - id: Reactome:R-HSA-9674093
    title: PDGFRs bind type I TKI
    findings: []