id: P01127
gene_symbol: PDGFB
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: >-
  PDGFB encodes the platelet-derived growth factor B chain, a secreted, disulfide-linked PDGF
  ligand subunit. Mature PDGF-B-containing dimers, especially PDGF-BB and PDGF-AB, bind and
  activate PDGF receptor dimers at the cell surface and drive paracrine growth-factor signaling.
  The core GO picture is receptor ligand/growth factor activity, PDGF receptor binding, extracellular
  and extracellular-matrix-associated localization, and PDGF-receptor signaling that promotes
  mural-cell/pericyte recruitment, vascular development, chemotaxis, migration, and proliferation
  in supported cell-type contexts. Receptor tyrosine kinase activity, receptor autophosphorylation,
  PI3K/AKT, ERK/MAPK, ROS/NADPH oxidase, and transcriptional outputs are downstream pathway
  consequences and should not be treated as core PDGFB molecular functions.
existing_annotations:
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        positive regulation of cell population proliferation is supported or plausible for
        PDGFB but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Broad positive regulation of cell population proliferation is a downstream growth-factor
        outcome. Keep it as supported but non-core; more specific cell-type proliferation
        terms and the core ligand/receptor-binding function are more informative.
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        positive regulation of cell migration is supported or plausible for PDGFB but represents
        a context-specific localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Broad positive regulation of cell migration is a downstream ligand response. Keep
        it as non-core where supported, while prioritizing cell-type-specific migration/chemotaxis
        and PDGF receptor signaling terms.
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        angiogenesis is supported for PDGFB in the context of its mature extracellular PDGF
        ligand function.
      action: ACCEPT
      reason: >-
        Angiogenesis is supported through the PDGF-B/PDGFRB endothelial-mural cell axis, especially
        pericyte recruitment and vessel stabilization.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B
        signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
        is biologically connected to PDGFB signaling but overstates the direct function of
        the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      reason: >-
        PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB
        molecular function and should not be promoted as core for the ligand.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        platelet-derived growth factor receptor binding is supported for PDGFB in the context
        of its mature extracellular PDGF ligand function.
      action: ACCEPT
      reason: >-
        PDGF receptor binding is a defining molecular function for PDGF-B-containing ligands.
        PDGF-BB and PDGF-AB bind PDGFRA/PDGFRB receptor dimers extracellularly and initiate
        PDGF receptor signaling.
      supported_by:
        - reference_id: file:human/PDGFB/PDGFB-deep-research-falcon.md
          supporting_text: >-
            **GO MF recommendations (plain-English):** “PDGF receptor binding” and “growth
            factor activity,” with the binding scope emphasizing **receptor dimer activation
            via extracellular ligand**, not receptor catalytic activity (fredriksson2004thepdgffamily
            pages 5-7, ostman1992pdgfaaandpdgfbb pages 1-2).
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        extracellular space is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular space is an appropriate localization for the mature secreted PDGF-B-containing
        ligand.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        positive regulation of ERK1 and ERK2 cascade is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      reason: >-
        ERK1/ERK2 cascade activation is downstream of PDGF receptor signaling. It is biologically
        connected but over-annotated for the PDGFB ligand compared with the PDGF receptor
        signaling pathway term.
  - term:
      id: GO:0050918
      label: positive chemotaxis
    evidence_type: IEA
    original_reference_id: GO_REF:0000108
    review:
      summary: >-
        positive chemotaxis is supported as a PDGF-B/PDGFR-dependent cell-type or chemotaxis
        process.
      action: ACCEPT
      reason: >-
        Accept. positive chemotaxis is a supported biological process downstream of PDGF-B-containing
        ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0007169
      label: cell surface receptor protein tyrosine kinase signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        cell surface receptor protein tyrosine kinase signaling pathway captures a related
        signaling idea, but the term has the wrong scope or aspect for PDGFB.
      action: MODIFY
      reason: >-
        The parent receptor tyrosine kinase signaling term is directionally correct but too
        broad. PDGFB specifically initiates platelet-derived growth factor receptor signaling.
      proposed_replacement_terms:
        - id: GO:0048008
          label: platelet-derived growth factor receptor signaling pathway
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: >-
        growth factor activity is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Growth factor activity is a core PDGFB function. The mature ligand acts extracellularly
        as a mitogen/chemoattractant for mesenchymal and vascular mural cell populations.
  - term:
      id: GO:0010468
      label: regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        regulation of gene expression is biologically connected to PDGFB signaling but overstates
        the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      reason: >-
        Regulation of gene expression is a broad downstream response to PDGF signaling and
        should not be treated as a PDGFB core function.
  - term:
      id: GO:0010557
      label: positive regulation of macromolecule biosynthetic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        positive regulation of macromolecule biosynthetic process is supported or plausible
        for PDGFB but represents a context-specific localization, storage, processing, or
        downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Macromolecule biosynthesis is a broad downstream response to PDGF signaling and is
        less informative than PDGF receptor signaling or cell-type-specific growth terms.
  - term:
      id: GO:0014911
      label: positive regulation of smooth muscle cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        positive regulation of smooth muscle cell migration is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      reason: >-
        Accept. smooth muscle cell migration is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: >-
        membrane is supported or plausible for PDGFB but represents a context-specific localization,
        storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Membrane is too broad for PDGFB; any membrane association is a precursor/retention
        or receptor-bound context, so keep only as non-core.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        receptor ligand activity is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Receptor ligand activity is an appropriate parent-level molecular function for PDGFB
        because the mature PDGF-B-containing dimer activates cell-surface PDGF receptors.
  - term:
      id: GO:0048661
      label: positive regulation of smooth muscle cell proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        positive regulation of smooth muscle cell proliferation is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      reason: >-
        Accept. smooth muscle cell proliferation is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0051239
      label: regulation of multicellular organismal process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        regulation of multicellular organismal process is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Regulation of multicellular organismal process is too broad for core PDGFB biology;
        retain only as a non-core propagated summary of developmental effects.
  - term:
      id: GO:0051781
      label: positive regulation of cell division
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: >-
        positive regulation of cell division is supported or plausible for PDGFB but represents
        a context-specific localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Positive regulation of cell division is a broad downstream outcome of growth-factor
        signaling, not a core ligand function.
  - term:
      id: GO:1902533
      label: positive regulation of intracellular signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        positive regulation of intracellular signal transduction is biologically connected
        to PDGFB signaling but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      reason: >-
        Positive regulation of intracellular signal transduction is too broad and downstream
        for the extracellular PDGFB ligand.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10806482
    review:
      summary: >-
        protein binding is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:10806482
          supporting_text: PDGF-C is a new protease-activated ligand for the PDGF
            alpha-receptor.
      reason: >-
        Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor
        binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix
        retention should be used instead.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11297552
    review:
      summary: >-
        protein binding is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:11297552
          supporting_text: 2001 Apr 10. Platelet-derived growth factor C (PDGF-C), a
            novel growth factor that binds to PDGF alpha and beta receptor.
      reason: >-
        Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor
        binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix
        retention should be used instead.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17981115
    review:
      summary: >-
        protein binding is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:17981115
          supporting_text: Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant
            tumors without affecting healthy vessels.
      reason: >-
        Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor
        binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix
        retention should be used instead.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20534510
    review:
      summary: >-
        protein binding is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:20534510
          supporting_text: Structures of a platelet-derived growth factor/propeptide
            complex and a platelet-derived growth factor/receptor complex.
      reason: >-
        Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor
        binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix
        retention should be used instead.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: >-
        protein binding is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein
            interactome.
      reason: >-
        Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor
        binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix
        retention should be used instead.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7679113
    review:
      summary: >-
        protein binding is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) AA, AB,
            and BB binding to alpha and beta PDGF receptor.
      reason: >-
        Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor
        binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix
        retention should be used instead.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:1396586
    review:
      summary: >-
        identical protein binding is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:1396586
          supporting_text: Crystal structure of human platelet-derived growth factor BB.
      reason: >-
        PDGFB forms the disulfide-linked PDGF-BB homodimer; identical protein binding captures
        that ligand-dimer assembly when supported by PDGF-BB structural or receptor-binding
        evidence.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:23139410
    review:
      summary: >-
        PMID:23139410 is a modified DNA aptamer/SOMAmer structure with PDGF-BB as the target,
        not direct evidence for PDGFB-PDGFB identical protein binding.
      action: REMOVE
      supported_by:
        - reference_id: PMID:23139410
          supporting_text: >-
            Here we report a unique crystal structure of a SOMAmer bound to its target,
            platelet-derived growth factor B (PDGF-BB).
      reason: >-
        Remove this specific GOA evidence row because the publication supports DNA aptamer
        binding to PDGF-BB rather than PDGFB self-association. The same GO term remains supported
        by PMID:1396586 and PMID:7679113.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:7679113
    review:
      summary: >-
        identical protein binding is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) AA, AB,
            and BB binding to alpha and beta PDGF receptor.
      reason: >-
        PDGFB forms the disulfide-linked PDGF-BB homodimer; identical protein binding captures
        that ligand-dimer assembly when supported by PDGF-BB structural or receptor-binding
        evidence.
  - term:
      id: GO:0036120
      label: cellular response to platelet-derived growth factor stimulus
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: >-
        cellular response to platelet-derived growth factor stimulus is biologically connected
        to PDGFB signaling but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth
            factor-induced vascular smooth muscle cell migration and proliferation by
            suppressing signal transduction and preventing cell entry to G1 phase.
      reason: >-
        Cellular response to platelet-derived growth factor stimulus describes responding
        cells; PDGFB is the ligand stimulus, so this is over-annotated for the gene product.
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: >-
        positive regulation of MAPK cascade is biologically connected to PDGFB signaling but
        overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth
            factor-induced vascular smooth muscle cell migration and proliferation by
            suppressing signal transduction and preventing cell entry to G1 phase.
      reason: >-
        MAPK cascade activation is downstream of receptor signaling and is less appropriate
        for PDGFB than PDGF receptor signaling pathway.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth
            factor-induced vascular smooth muscle cell migration and proliferation by
            suppressing signal transduction and preventing cell entry to G1 phase.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0014805
      label: smooth muscle adaptation
    evidence_type: NAS
    original_reference_id: PMID:16477012
    review:
      summary: >-
        smooth muscle adaptation is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:16477012
          supporting_text: Synergistic roles of platelet-derived growth factor-BB and
            interleukin-1beta in phenotypic modulation of human aortic smooth muscle
            cells.
      reason: >-
        Smooth muscle adaptation is a vascular smooth muscle phenotype downstream of PDGF
        signaling and should remain non-core.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:16477012
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:16477012
          supporting_text: Synergistic roles of platelet-derived growth factor-BB and
            interleukin-1beta in phenotypic modulation of human aortic smooth muscle
            cells.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B
        signal transduction
    evidence_type: IDA
    original_reference_id: PMID:16477012
    review:
      summary: >-
        positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
        is biologically connected to PDGFB signaling but overstates the direct function of
        the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:16477012
          supporting_text: Synergistic roles of platelet-derived growth factor-BB and
            interleukin-1beta in phenotypic modulation of human aortic smooth muscle
            cells.
      reason: >-
        PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB
        molecular function and should not be promoted as core for the ligand.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: NAS
    original_reference_id: PMID:7679113
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:7679113
          supporting_text: Mechanism of platelet-derived growth factor (PDGF) AA, AB,
            and BB binding to alpha and beta PDGF receptor.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0035556
      label: intracellular signal transduction
    evidence_type: IMP
    original_reference_id: PMID:24008408
    review:
      summary: >-
        intracellular signal transduction is biologically connected to PDGFB signaling but
        overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:24008408
          supporting_text: CAP37 activation of PKC promotes human corneal epithelial
            cell chemotaxis.
      reason: >-
        Intracellular signal transduction is a downstream cellular response and not an activity
        or localization of the secreted PDGFB ligand.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: >-
        positive regulation of cell population proliferation is supported or plausible for
        PDGFB but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to
            PDGF-induced DNA synthesis in mesangial cells.
      reason: >-
        Broad positive regulation of cell population proliferation is a downstream growth-factor
        outcome. Keep it as supported but non-core; more specific cell-type proliferation
        terms and the core ligand/receptor-binding function are more informative.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: >-
        gene expression is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to
            PDGF-induced DNA synthesis in mesangial cells.
      reason: >-
        Gene expression is a downstream cellular response and is over-annotated for the PDGFB
        ligand.
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: >-
        negative regulation of gene expression is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to
            PDGF-induced DNA synthesis in mesangial cells.
      reason: >-
        Negative regulation of gene expression is a downstream transcriptional response to
        PDGF signaling, not a core ligand function.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to
            PDGF-induced DNA synthesis in mesangial cells.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B
        signal transduction
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: >-
        positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
        is biologically connected to PDGFB signaling but overstates the direct function of
        the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to
            PDGF-induced DNA synthesis in mesangial cells.
      reason: >-
        PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB
        molecular function and should not be promoted as core for the ligand.
  - term:
      id: GO:1904707
      label: positive regulation of vascular associated smooth muscle cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: >-
        positive regulation of vascular associated smooth muscle cell proliferation is supported
        as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived growth
            factor signaling is critical for modulation of vascular smooth muscle
            phenotype.
      reason: >-
        Accept. vascular smooth muscle cell proliferation is a supported biological process
        downstream of PDGF-B-containing ligand signaling and is sufficiently specific to retain
        for PDGFB.
  - term:
      id: GO:1905064
      label: negative regulation of vascular associated smooth muscle cell
        differentiation
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: >-
        negative regulation of vascular associated smooth muscle cell differentiation is supported
        or plausible for PDGFB but represents a context-specific localization, storage, processing,
        or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived growth
            factor signaling is critical for modulation of vascular smooth muscle
            phenotype.
      reason: >-
        Negative regulation of vascular smooth muscle differentiation is a supported VSMC
        phenotype of PDGF-BB treatment but is secondary to the core ligand/receptor signaling
        function.
  - term:
      id: GO:1905176
      label: positive regulation of vascular associated smooth muscle cell
        dedifferentiation
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: >-
        positive regulation of vascular associated smooth muscle cell dedifferentiation is
        supported or plausible for PDGFB but represents a context-specific localization, storage,
        processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived growth
            factor signaling is critical for modulation of vascular smooth muscle
            phenotype.
      reason: >-
        Positive regulation of vascular smooth muscle dedifferentiation is a supported VSMC
        phenotype but is secondary to core PDGFB ligand activity.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: EXP
    original_reference_id: PMID:20534510
    review:
      summary: >-
        platelet-derived growth factor receptor binding is supported for PDGFB in the context
        of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:20534510
          supporting_text: Structures of a platelet-derived growth factor/propeptide
            complex and a platelet-derived growth factor/receptor complex.
      reason: >-
        PDGF receptor binding is a defining molecular function for PDGF-B-containing ligands.
        PDGF-BB and PDGF-AB bind PDGFRA/PDGFRB receptor dimers extracellularly and initiate
        PDGF receptor signaling.
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        positive regulation of gene expression is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      reason: >-
        Positive regulation of gene expression is a downstream transcriptional response to
        PDGF signaling, not a core ligand function.
  - term:
      id: GO:0036120
      label: cellular response to platelet-derived growth factor stimulus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        cellular response to platelet-derived growth factor stimulus is biologically connected
        to PDGFB signaling but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      reason: >-
        Cellular response to platelet-derived growth factor stimulus describes responding
        cells; PDGFB is the ligand stimulus, so this is over-annotated for the gene product.
  - term:
      id: GO:0048661
      label: positive regulation of smooth muscle cell proliferation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        positive regulation of smooth muscle cell proliferation is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      reason: >-
        Accept. smooth muscle cell proliferation is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: >-
        negative regulation of gene expression is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human vascular
            smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and
            migration through targeting orphan nuclear receptor NOR1.
      reason: >-
        Negative regulation of gene expression is a downstream transcriptional response to
        PDGF signaling, not a core ligand function.
  - term:
      id: GO:1902894
      label: negative regulation of miRNA transcription
    evidence_type: IDA
    original_reference_id: PMID:26493107
    review:
      summary: >-
        negative regulation of miRNA transcription is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:26493107
          supporting_text: Epub 2015 Oct 19. miRNA-34a reduces neointima formation
            through inhibiting smooth muscle cell proliferation and migration.
      reason: >-
        Negative regulation of miRNA transcription is a downstream VSMC transcriptional effect
        and not a core PDGFB function.
  - term:
      id: GO:1902895
      label: positive regulation of miRNA transcription
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: >-
        positive regulation of miRNA transcription is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived growth
            factor signaling is critical for modulation of vascular smooth muscle
            phenotype.
      reason: >-
        Positive regulation of miRNA transcription is a downstream VSMC transcriptional effect
        and not a core PDGFB function.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B
        signal transduction
    evidence_type: IDA
    original_reference_id: PMID:19126672
    review:
      summary: >-
        positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
        is biologically connected to PDGFB signaling but overstates the direct function of
        the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:19126672
          supporting_text: Jan 6. Spontaneous phosphoinositide 3-kinase signaling
            dynamics drive spreading and random migration of fibroblasts.
      reason: >-
        PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB
        molecular function and should not be promoted as core for the ligand.
  - term:
      id: GO:0010811
      label: positive regulation of cell-substrate adhesion
    evidence_type: IDA
    original_reference_id: PMID:19126672
    review:
      summary: >-
        positive regulation of cell-substrate adhesion is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:19126672
          supporting_text: Jan 6. Spontaneous phosphoinositide 3-kinase signaling
            dynamics drive spreading and random migration of fibroblasts.
      reason: >-
        Cell-substrate adhesion is a downstream cellular behavior in PDGF-stimulated cells
        and is non-core relative to ligand binding and receptor signaling.
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: >-
        positive regulation of gene expression is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human vascular
            smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and
            migration through targeting orphan nuclear receptor NOR1.
      reason: >-
        Positive regulation of gene expression is a downstream transcriptional response to
        PDGF signaling, not a core ligand function.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human vascular
            smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and
            migration through targeting orphan nuclear receptor NOR1.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:1904707
      label: positive regulation of vascular associated smooth muscle cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: >-
        positive regulation of vascular associated smooth muscle cell proliferation is supported
        as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human vascular
            smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and
            migration through targeting orphan nuclear receptor NOR1.
      reason: >-
        Accept. vascular smooth muscle cell proliferation is a supported biological process
        downstream of PDGF-B-containing ligand signaling and is sufficiently specific to retain
        for PDGFB.
  - term:
      id: GO:1904754
      label: positive regulation of vascular associated smooth muscle cell migration
    evidence_type: IDA
    original_reference_id: PMID:23554459
    review:
      summary: >-
        positive regulation of vascular associated smooth muscle cell migration is supported
        as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:23554459
          supporting_text: Apr 3. MicroRNA-638 is highly expressed in human vascular
            smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and
            migration through targeting orphan nuclear receptor NOR1.
      reason: >-
        Accept. vascular smooth muscle cell migration is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: >-
        positive regulation of cell population proliferation is supported or plausible for
        PDGFB but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human
            osteosarcoma cells but does not stimulate cell replication.
      reason: >-
        Broad positive regulation of cell population proliferation is a downstream growth-factor
        outcome. Keep it as supported but non-core; more specific cell-type proliferation
        terms and the core ligand/receptor-binding function are more informative.
  - term:
      id: GO:0031012
      label: extracellular matrix
    evidence_type: HDA
    original_reference_id: PMID:23979707
    review:
      summary: >-
        extracellular matrix is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:23979707
          supporting_text: Epub 2013 Aug 26. SILAC-based proteomics of human primary
            endothelial cell morphogenesis unveils tumor angiogenic markers.
      reason: >-
        Extracellular matrix association is supported by the PDGF-B C-terminal retention motif
        and heparan-sulfate/extracellular-matrix retention evidence.
  - term:
      id: GO:1904707
      label: positive regulation of vascular associated smooth muscle cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:12070119
    review:
      summary: >-
        positive regulation of vascular associated smooth muscle cell proliferation is supported
        as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as a
            platelet-derived growth factor-BB-binding protein and regulates growth
            factor-induced common postreceptor signal in vascular smooth muscle cell.
      reason: >-
        Accept. vascular smooth muscle cell proliferation is a supported biological process
        downstream of PDGF-B-containing ligand signaling and is sufficiently specific to retain
        for PDGFB.
  - term:
      id: GO:1904754
      label: positive regulation of vascular associated smooth muscle cell migration
    evidence_type: IDA
    original_reference_id: PMID:12070119
    review:
      summary: >-
        positive regulation of vascular associated smooth muscle cell migration is supported
        as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as a
            platelet-derived growth factor-BB-binding protein and regulates growth
            factor-induced common postreceptor signal in vascular smooth muscle cell.
      reason: >-
        Accept. vascular smooth muscle cell migration is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0048661
      label: positive regulation of smooth muscle cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:21321938
    review:
      summary: >-
        positive regulation of smooth muscle cell proliferation is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:21321938
          supporting_text: Interleukin-18/WNT1-inducible signaling pathway protein-1
            signaling mediates human saphenous vein smooth muscle cell proliferation.
      reason: >-
        Accept. smooth muscle cell proliferation is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0035655
      label: interleukin-18-mediated signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:21321938
    review:
      summary: >-
        interleukin-18-mediated signaling pathway is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:21321938
          supporting_text: Interleukin-18/WNT1-inducible signaling pathway protein-1
            signaling mediates human saphenous vein smooth muscle cell proliferation.
      reason: >-
        Interleukin-18-mediated signaling is a context-specific downstream inflammatory pathway
        and not a direct PDGFB ligand function.
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:25089138
    review:
      summary: >-
        negative regulation of gene expression is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:25089138
          supporting_text: 2014 Jul 25. miR-18a-5p MicroRNA Increases Vascular Smooth
            Muscle Cell Differentiation by Downregulating Syndecan4.
      reason: >-
        Negative regulation of gene expression is a downstream transcriptional response to
        PDGF signaling, not a core ligand function.
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:25089138
    review:
      summary: >-
        negative regulation of DNA-templated transcription is biologically connected to PDGFB
        signaling but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:25089138
          supporting_text: 2014 Jul 25. miR-18a-5p MicroRNA Increases Vascular Smooth
            Muscle Cell Differentiation by Downregulating Syndecan4.
      reason: >-
        Negative regulation of DNA-templated transcription is a downstream transcriptional
        response and is over-annotated for the extracellular ligand.
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865275
    review:
      summary: >-
        Golgi lumen is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Golgi lumen reflects secretory processing of PDGF-B precursors and should be retained
        as non-core rather than treated as the mature ligand localization.
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: >-
        Golgi lumen is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Golgi lumen reflects secretory processing of PDGF-B precursors and should be retained
        as non-core rather than treated as the mature ligand localization.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1524182
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1524186
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186765
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186773
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186778
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186780
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186786
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186798
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186800
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186819
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186826
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-186834
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2316434
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2396337
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2400009
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-380780
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-380782
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382052
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382054
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382055
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382056
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382058
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389083
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389086
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-481007
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5672965
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8864036
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865275
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9674093
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived growth
            factor signaling is critical for modulation of vascular smooth muscle
            phenotype.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:1904754
      label: positive regulation of vascular associated smooth muscle cell migration
    evidence_type: IDA
    original_reference_id: PMID:19088079
    review:
      summary: >-
        positive regulation of vascular associated smooth muscle cell migration is supported
        as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:19088079
          supporting_text: Dec 15. Induction of microRNA-221 by platelet-derived growth
            factor signaling is critical for modulation of vascular smooth muscle
            phenotype.
      reason: >-
        Accept. vascular smooth muscle cell migration is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: >-
        platelet-derived growth factor receptor binding is supported for PDGFB in the context
        of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human
            osteosarcoma cells but does not stimulate cell replication.
      reason: >-
        PDGF receptor binding is a defining molecular function for PDGF-B-containing ligands.
        PDGF-BB and PDGF-AB bind PDGFRA/PDGFRB receptor dimers extracellularly and initiate
        PDGF receptor signaling.
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IDA
    original_reference_id: PMID:12070119
    review:
      summary: >-
        growth factor activity is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as a
            platelet-derived growth factor-BB-binding protein and regulates growth
            factor-induced common postreceptor signal in vascular smooth muscle cell.
      reason: >-
        Growth factor activity is a core PDGFB function. The mature ligand acts extracellularly
        as a mitogen/chemoattractant for mesenchymal and vascular mural cell populations.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: >-
        cell surface is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of
            platelet-derived growth factor leading to inhibition of P43 and P20
            phosphorylation.
      reason: >-
        Cell surface association is compatible with PDGF receptor binding and heparan-sulfate
        retention, but extracellular region/matrix are more precise mature ligand locations.
  - term:
      id: GO:0005788
      label: endoplasmic reticulum lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382053
    review:
      summary: >-
        endoplasmic reticulum lumen is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Endoplasmic reticulum lumen reflects precursor folding/dimerization in the secretory
        pathway and is non-core for the mature extracellular ligand.
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382053
    review:
      summary: >-
        Golgi membrane is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Golgi membrane reflects secretory pathway processing/trafficking context and is non-core
        for the mature extracellular ligand.
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865275
    review:
      summary: >-
        Golgi membrane is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Golgi membrane reflects secretory pathway processing/trafficking context and is non-core
        for the mature extracellular ligand.
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865276
    review:
      summary: >-
        Golgi membrane is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Golgi membrane reflects secretory pathway processing/trafficking context and is non-core
        for the mature extracellular ligand.
  - term:
      id: GO:0031093
      label: platelet alpha granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-481007
    review:
      summary: >-
        platelet alpha granule lumen is supported or plausible for PDGFB but represents a
        context-specific localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Platelet alpha granule lumen is a supported storage/release localization for platelet
        PDGF-B, but not the primary mature-ligand site of action.
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: >-
        positive regulation of cell migration is supported or plausible for PDGFB but represents
        a context-specific localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas tyrosine
            phosphorylation is essential for growth factor-dependent migration of glioma
            and endothelial cells.
      reason: >-
        Broad positive regulation of cell migration is a downstream ligand response. Keep
        it as non-core where supported, while prioritizing cell-type-specific migration/chemotaxis
        and PDGF receptor signaling terms.
  - term:
      id: GO:0042056
      label: chemoattractant activity
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: >-
        chemoattractant activity is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas tyrosine
            phosphorylation is essential for growth factor-dependent migration of glioma
            and endothelial cells.
      reason: >-
        Chemoattractant activity is consistent with PDGF-BB ligand function and the chemotactic
        responses to PDGF-B-containing ligands.
  - term:
      id: GO:0071363
      label: cellular response to growth factor stimulus
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: >-
        cellular response to growth factor stimulus is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas tyrosine
            phosphorylation is essential for growth factor-dependent migration of glioma
            and endothelial cells.
      reason: >-
        Cellular response to growth factor stimulus describes responding cells and is over-annotated
        for the extracellular PDGFB ligand.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:2536956
    review:
      summary: >-
        protein binding is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:2536956
          supporting_text: Isolation of a novel receptor cDNA establishes the existence
            of two PDGF receptor genes.
      reason: >-
        Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor
        binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix
        retention should be used instead.
  - term:
      id: GO:1900127
      label: positive regulation of hyaluronan biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:17324121
    review:
      summary: >-
        positive regulation of hyaluronan biosynthetic process is supported or plausible for
        PDGFB but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:17324121
          supporting_text: 'Growth factor regulation of hyaluronan synthesis and degradation
            in human dermal fibroblasts: importance of hyaluronan for the mitogenic response
            of PDGF-BB.'
      reason: >-
        Hyaluronan biosynthesis is a fibroblast/extracellular-matrix downstream response to
        PDGF stimulation and is non-core.
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:17324121
    review:
      summary: >-
        positive regulation of DNA-templated transcription is biologically connected to PDGFB
        signaling but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:17324121
          supporting_text: 'Growth factor regulation of hyaluronan synthesis and degradation
            in human dermal fibroblasts: importance of hyaluronan for the mitogenic response
            of PDGF-BB.'
      reason: >-
        Positive regulation of DNA-templated transcription is a downstream transcriptional
        response and is over-annotated for the extracellular ligand.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:17324121
    review:
      summary: >-
        positive regulation of fibroblast proliferation is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:17324121
          supporting_text: 'Growth factor regulation of hyaluronan synthesis and degradation
            in human dermal fibroblasts: importance of hyaluronan for the mitogenic response
            of PDGF-BB.'
      reason: >-
        Accept. fibroblast proliferation is a supported biological process downstream of PDGF-B-containing
        ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0030097
      label: hemopoiesis
    evidence_type: IMP
    original_reference_id: PMID:11264163
    negated: true
    review:
      summary: >-
        hemopoiesis is supported for PDGFB in the context of its mature extracellular PDGF
        ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:11264163
          supporting_text: Basis of hematopoietic defects in platelet-derived growth
            factor (PDGF)-B and PDGF beta-receptor null mice.
      reason: >-
        Accept as a NOT annotation. The cited mouse chimera study indicates hematopoietic
        PDGF-B/PDGFRB expression is not required for normal hematopoiesis, while non-hematopoietic
        PDGF signaling has inflammatory roles.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas tyrosine
            phosphorylation is essential for growth factor-dependent migration of glioma
            and endothelial cells.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0060326
      label: cell chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:21245381
    review:
      summary: >-
        cell chemotaxis is supported as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:21245381
          supporting_text: Jan 18. Neuropilin-1 signaling through p130Cas tyrosine
            phosphorylation is essential for growth factor-dependent migration of glioma
            and endothelial cells.
      reason: >-
        Accept. cell chemotaxis is a supported biological process downstream of PDGF-B-containing
        ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0035793
      label: positive regulation of metanephric mesenchymal cell migration by
        platelet-derived growth factor receptor-beta signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: >-
        positive regulation of metanephric mesenchymal cell migration by platelet-derived
        growth factor receptor-beta signaling pathway is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
      reason: >-
        Accept. metanephric mesenchymal cell migration via PDGFRB signaling is a supported
        biological process downstream of PDGF-B-containing ligand signaling and is sufficiently
        specific to retain for PDGFB.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:10644978
    review:
      summary: >-
        positive regulation of DNA biosynthetic process is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:10644978
          supporting_text: PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated
            mitogenesis.
      reason: >-
        DNA biosynthetic process is a downstream mitogenic readout of PDGF receptor signaling,
        not a direct PDGFB molecular function.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: >-
        positive regulation of DNA biosynthetic process is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta regulates
            migration and DNA synthesis in metanephric mesenchymal cells.
      reason: >-
        DNA biosynthetic process is a downstream mitogenic readout of PDGF receptor signaling,
        not a direct PDGFB molecular function.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: >-
        positive regulation of DNA biosynthetic process is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in rat
            metanephric mesenchymal cells.
      reason: >-
        DNA biosynthetic process is a downstream mitogenic readout of PDGF receptor signaling,
        not a direct PDGFB molecular function.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: >-
        positive regulation of DNA biosynthetic process is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived growth
            factor beta in metanephric mesenchymal cells.
      reason: >-
        DNA biosynthetic process is a downstream mitogenic readout of PDGF receptor signaling,
        not a direct PDGFB molecular function.
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: >-
        positive regulation of DNA biosynthetic process is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
      reason: >-
        DNA biosynthetic process is a downstream mitogenic readout of PDGF receptor signaling,
        not a direct PDGFB molecular function.
  - term:
      id: GO:2000591
      label: positive regulation of metanephric mesenchymal cell migration
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: >-
        positive regulation of metanephric mesenchymal cell migration is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta regulates
            migration and DNA synthesis in metanephric mesenchymal cells.
      reason: >-
        Accept. metanephric mesenchymal cell migration is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0016323
      label: basolateral plasma membrane
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        basolateral plasma membrane is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Basolateral plasma membrane is a polarized-cell localization context and not the mature
        ligand core localization.
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: IDA
    original_reference_id: PMID:10644978
    review:
      summary: >-
        positive regulation of mitotic nuclear division is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:10644978
          supporting_text: PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated
            mitogenesis.
      reason: >-
        Mitotic nuclear division is a downstream proliferation readout of PDGF signaling and
        should not be promoted as a core PDGFB function.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:10644978
    review:
      summary: >-
        positive regulation of fibroblast proliferation is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:10644978
          supporting_text: PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated
            mitogenesis.
      reason: >-
        Accept. fibroblast proliferation is a supported biological process downstream of PDGF-B-containing
        ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0060326
      label: cell chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:16014047
    review:
      summary: >-
        cell chemotaxis is supported as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:16014047
          supporting_text: Hypoxia regulates PDGF-B interactions between glomerular
            capillary endothelial and mesangial cells.
      reason: >-
        Accept. cell chemotaxis is a supported biological process downstream of PDGF-B-containing
        ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0060326
      label: cell chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:17991872
    review:
      summary: >-
        cell chemotaxis is supported as a PDGF-B/PDGFR-dependent cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:17991872
          supporting_text: 'TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis
            in different cell types: involvement of Src and PLC.'
      reason: >-
        Accept. cell chemotaxis is a supported biological process downstream of PDGF-B-containing
        ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:16530387
    review:
      summary: >-
        positive regulation of ERK1 and ERK2 cascade is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:16530387
          supporting_text: c-Src couples PI 3 kinase/Akt and MAPK signaling to
            PDGF-induced DNA synthesis in mesangial cells.
      reason: >-
        ERK1/ERK2 cascade activation is downstream of PDGF receptor signaling. It is biologically
        connected but over-annotated for the PDGFB ligand compared with the PDGF receptor
        signaling pathway term.
  - term:
      id: GO:0072126
      label: positive regulation of glomerular mesangial cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:16014047
    review:
      summary: >-
        positive regulation of glomerular mesangial cell proliferation is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:16014047
          supporting_text: Hypoxia regulates PDGF-B interactions between glomerular
            capillary endothelial and mesangial cells.
      reason: >-
        Real but non-core: glomerular mesangial cell proliferation is a
        tissue-specific process downstream of PDGF-B/PDGFR ligand signaling, not
        a core molecular function of the secreted ligand. Surfaced by the
        ASSAY_TO_FUNCTION analysis (indirect signaling-ligand effect on a
        proliferation readout).
  - term:
      id: GO:0018108
      label: peptidyl-tyrosine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: >-
        peptidyl-tyrosine phosphorylation captures a related signaling idea, but the term
        has the wrong scope or aspect for PDGFB.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0048008
          label: platelet-derived growth factor receptor signaling pathway
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta regulates
            migration and DNA synthesis in metanephric mesenchymal cells.
      reason: >-
        The evidence describes PDGF receptor autophosphorylation after ligand binding. PDGFB
        is not the tyrosine kinase; replace the phosphorylation term with PDGF receptor signaling
        pathway.
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: >-
        positive regulation of cell migration is supported or plausible for PDGFB but represents
        a context-specific localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in rat
            metanephric mesenchymal cells.
      reason: >-
        Broad positive regulation of cell migration is a downstream ligand response. Keep
        it as non-core where supported, while prioritizing cell-type-specific migration/chemotaxis
        and PDGF receptor signaling terms.
  - term:
      id: GO:0043406
      label: positive regulation of MAP kinase activity
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: >-
        positive regulation of MAP kinase activity is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in rat
            metanephric mesenchymal cells.
      reason: >-
        Positive regulation of MAP kinase activity is a downstream receptor/effectors readout,
        not a direct PDGFB activity.
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IMP
    original_reference_id: PMID:11788434
    review:
      summary: >-
        positive regulation of MAPK cascade is biologically connected to PDGFB signaling but
        overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in rat
            metanephric mesenchymal cells.
      reason: >-
        MAPK cascade activation is downstream of receptor signaling and is less appropriate
        for PDGFB than PDGF receptor signaling pathway.
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: >-
        positive regulation of mitotic nuclear division is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta regulates
            migration and DNA synthesis in metanephric mesenchymal cells.
      reason: >-
        Mitotic nuclear division is a downstream proliferation readout of PDGF signaling and
        should not be promoted as a core PDGFB function.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B
        signal transduction
    evidence_type: IDA
    original_reference_id: PMID:10734101
    review:
      summary: >-
        positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
        is biologically connected to PDGFB signaling but overstates the direct function of
        the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:10734101
          supporting_text: Platelet-derived growth factor receptor beta regulates
            migration and DNA synthesis in metanephric mesenchymal cells.
      reason: >-
        PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB
        molecular function and should not be promoted as core for the ligand.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B
        signal transduction
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: >-
        positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
        is biologically connected to PDGFB signaling but overstates the direct function of
        the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in rat
            metanephric mesenchymal cells.
      reason: >-
        PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB
        molecular function and should not be promoted as core for the ligand.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B
        signal transduction
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: >-
        positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
        is biologically connected to PDGFB signaling but overstates the direct function of
        the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived growth
            factor beta in metanephric mesenchymal cells.
      reason: >-
        PI3K/AKT signaling is a downstream PDGF receptor pathway. It is not a direct PDGFB
        molecular function and should not be promoted as core for the ligand.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: >-
        positive regulation of ERK1 and ERK2 cascade is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in rat
            metanephric mesenchymal cells.
      reason: >-
        ERK1/ERK2 cascade activation is downstream of PDGF receptor signaling. It is biologically
        connected but over-annotated for the PDGFB ligand compared with the PDGF receptor
        signaling pathway term.
  - term:
      id: GO:0072126
      label: positive regulation of glomerular mesangial cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:11788434
    review:
      summary: >-
        positive regulation of glomerular mesangial cell proliferation is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:11788434
          supporting_text: Effect of platelet-derived growth factor isoforms in rat
            metanephric mesenchymal cells.
      reason: >-
        Real but non-core, consistent with the GO:0072126 annotation from
        PMID:16014047: a tissue-specific proliferation process downstream of
        PDGF-B/PDGFR signaling rather than a core molecular function.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: >-
        protein phosphorylation captures a related signaling idea, but the term has the wrong
        scope or aspect for PDGFB.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0048008
          label: platelet-derived growth factor receptor signaling pathway
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived growth
            factor beta in metanephric mesenchymal cells.
      reason: >-
        The evidence describes downstream phosphorylation after PDGFB activates PDGF receptors.
        PDGFB itself does not catalyze protein phosphorylation, so replace with PDGF receptor
        signaling pathway.
  - term:
      id: GO:0016176
      label: superoxide-generating NADPH oxidase activator activity
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: >-
        superoxide-generating NADPH oxidase activator activity is not supported as a PDGFB
        gene-product function or mature localization.
      action: REMOVE
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived growth
            factor beta in metanephric mesenchymal cells.
      reason: >-
        Remove. Superoxide-generating NADPH oxidase activator activity belongs to NADPH oxidase
        regulatory machinery, not to the secreted PDGFB ligand.
  - term:
      id: GO:0043406
      label: positive regulation of MAP kinase activity
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: >-
        positive regulation of MAP kinase activity is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived growth
            factor beta in metanephric mesenchymal cells.
      reason: >-
        Positive regulation of MAP kinase activity is a downstream receptor/effectors readout,
        not a direct PDGFB activity.
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: >-
        positive regulation of mitotic nuclear division is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived growth
            factor beta in metanephric mesenchymal cells.
      reason: >-
        Mitotic nuclear division is a downstream proliferation readout of PDGF signaling and
        should not be promoted as a core PDGFB function.
  - term:
      id: GO:0050921
      label: positive regulation of chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: >-
        positive regulation of chemotaxis is supported as a PDGF-B/PDGFR-dependent cell-type
        or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
      reason: >-
        Accept. positive regulation of chemotaxis is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:17942966
    review:
      summary: >-
        positive regulation of ERK1 and ERK2 cascade is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived growth
            factor beta in metanephric mesenchymal cells.
      reason: >-
        ERK1/ERK2 cascade activation is downstream of PDGF receptor signaling. It is biologically
        connected but over-annotated for the PDGFB ligand compared with the PDGF receptor
        signaling pathway term.
  - term:
      id: GO:0072593
      label: reactive oxygen species metabolic process
    evidence_type: IMP
    original_reference_id: PMID:17942966
    review:
      summary: >-
        reactive oxygen species metabolic process is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:17942966
          supporting_text: 2007 Oct 17. Mitogenic signaling via platelet-derived growth
            factor beta in metanephric mesenchymal cells.
      reason: >-
        Reactive oxygen species metabolism is a downstream PDGFR/NADPH oxidase pathway readout
        and should not be assigned as a PDGFB core process.
  - term:
      id: GO:0090280
      label: positive regulation of calcium ion import
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: >-
        positive regulation of calcium ion import is biologically connected to PDGFB signaling
        but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
      reason: >-
        Calcium ion import is a downstream PDGFRB signaling response, not a direct PDGFB ligand
        function.
  - term:
      id: GO:2000379
      label: positive regulation of reactive oxygen species metabolic process
    evidence_type: IDA
    original_reference_id: PMID:19019919
    review:
      summary: >-
        positive regulation of reactive oxygen species metabolic process is biologically connected
        to PDGFB signaling but overstates the direct function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:19019919
          supporting_text: PDGF receptor-{beta} modulates metanephric mesenchyme
            chemotaxis induced by PDGF AA.
      reason: >-
        Reactive oxygen species regulation is downstream of receptor signaling and NADPH oxidases
        and is over-annotated for PDGFB.
  - term:
      id: GO:0001892
      label: embryonic placenta development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        embryonic placenta development is supported or plausible for PDGFB but represents
        a context-specific localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Placenta development is consistent with organismal phenotypes of PDGFB/PDGFRB disruption
        but is a developmental outcome, not a core molecular function.
  - term:
      id: GO:0003104
      label: positive regulation of glomerular filtration
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        positive regulation of glomerular filtration is supported or plausible for PDGFB but
        represents a context-specific localization, storage, processing, or downstream biological
        outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Glomerular filtration is an organ-level consequence of PDGFB-dependent glomerular/mesangial
        development and should be kept as non-core.
  - term:
      id: GO:0007507
      label: heart development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        heart development is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Heart development is a broad developmental outcome of PDGFB pathway function and is
        non-core for this ligand review.
  - term:
      id: GO:0038001
      label: paracrine signaling
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        paracrine signaling is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      reason: >-
        Paracrine signaling is appropriate for PDGFB because endothelial and platelet-derived
        PDGF-B acts as an extracellular signal to neighboring PDGF receptor-expressing cells.
  - term:
      id: GO:0072255
      label: metanephric glomerular mesangial cell development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        metanephric glomerular mesangial cell development is supported or plausible for PDGFB
        but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      reason: >-
        Metanephric glomerular mesangial cell development is a supported developmental role
        downstream of PDGFB/PDGFRB signaling, but non-core relative to ligand activity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12070119
    review:
      summary: >-
        protein binding is biologically connected to PDGFB signaling but overstates the direct
        function of the secreted ligand.
      action: MARK_AS_OVER_ANNOTATED
      supported_by:
        - reference_id: PMID:12070119
          supporting_text: Adipocyte-derived plasma protein adiponectin acts as a
            platelet-derived growth factor-BB-binding protein and regulates growth
            factor-induced common postreceptor signal in vascular smooth muscle cell.
      reason: >-
        Generic protein binding is uninformative for PDGFB. Specific terms such as PDGF receptor
        binding, collagen binding, homodimerization, heterodimerization, or extracellular-matrix
        retention should be used instead.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        cytoplasm is not supported as a PDGFB gene-product function or mature localization.
      action: REMOVE
      reason: >-
        Remove. PDGFB is a secretory pathway/extracellular ligand; cytoplasm is not a supported
        mature localization for this gene product in the reviewed evidence.
  - term:
      id: GO:0071506
      label: cellular response to mycophenolic acid
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        cellular response to mycophenolic acid is not supported as a PDGFB gene-product function
        or mature localization.
      action: REMOVE
      reason: >-
        Remove. Cellular response to mycophenolic acid is a drug-response annotation and does
        not represent PDGFB ligand function.
  - term:
      id: GO:0002548
      label: monocyte chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:17991872
    review:
      summary: >-
        monocyte chemotaxis is supported as a PDGF-B/PDGFR-dependent cell-type or chemotaxis
        process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:17991872
          supporting_text: 'TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis
            in different cell types: involvement of Src and PLC.'
      reason: >-
        Accept. monocyte chemotaxis is a supported biological process downstream of PDGF-B-containing
        ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0005518
      label: collagen binding
    evidence_type: IDA
    original_reference_id: PMID:8900172
    review:
      summary: >-
        collagen binding is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:8900172
          supporting_text: Type I, II, III, IV, V, and VI collagens serve as
            extracellular ligands for the isoforms of platelet-derived growth factor
            (AA, BB, and AB).
      reason: >-
        Collagen binding is a supported, specific extracellular-matrix interaction for PDGF
        isoforms and is more informative than generic protein binding.
  - term:
      id: GO:0014911
      label: positive regulation of smooth muscle cell migration
    evidence_type: IDA
    original_reference_id: PMID:9409235
    review:
      summary: >-
        positive regulation of smooth muscle cell migration is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:9409235
          supporting_text: Platelet-derived growth factor beta-receptors can both
            promote and inhibit chemotaxis in human vascular smooth muscle cells.
      reason: >-
        Accept. smooth muscle cell migration is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0050921
      label: positive regulation of chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:9409235
    review:
      summary: >-
        positive regulation of chemotaxis is supported as a PDGF-B/PDGFR-dependent cell-type
        or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:9409235
          supporting_text: Platelet-derived growth factor beta-receptors can both
            promote and inhibit chemotaxis in human vascular smooth muscle cells.
      reason: >-
        Accept. positive regulation of chemotaxis is a supported biological process downstream
        of PDGF-B-containing ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IPI
    original_reference_id: PMID:2536956
    review:
      summary: >-
        platelet-derived growth factor receptor binding is supported for PDGFB in the context
        of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:2536956
          supporting_text: Isolation of a novel receptor cDNA establishes the existence
            of two PDGF receptor genes.
      reason: >-
        PDGF receptor binding is a defining molecular function for PDGF-B-containing ligands.
        PDGF-BB and PDGF-AB bind PDGFRA/PDGFRB receptor dimers extracellularly and initiate
        PDGF receptor signaling.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2536956
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:2536956
          supporting_text: Isolation of a novel receptor cDNA establishes the existence
            of two PDGF receptor genes.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: >-
        platelet-derived growth factor receptor binding is supported for PDGFB in the context
        of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A and B
            forms of PDGF.
      reason: >-
        PDGF receptor binding is a defining molecular function for PDGF-B-containing ligands.
        PDGF-BB and PDGF-AB bind PDGFRA/PDGFRB receptor dimers extracellularly and initiate
        PDGF receptor signaling.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: >-
        positive regulation of cell population proliferation is supported or plausible for
        PDGFB but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A and B
            forms of PDGF.
      reason: >-
        Broad positive regulation of cell population proliferation is a downstream growth-factor
        outcome. Keep it as supported but non-core; more specific cell-type proliferation
        terms and the core ligand/receptor-binding function are more informative.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:7073684
    review:
      summary: >-
        positive regulation of cell population proliferation is supported or plausible for
        PDGFB but represents a context-specific localization, storage, processing, or downstream
        biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
      reason: >-
        Broad positive regulation of cell population proliferation is a downstream growth-factor
        outcome. Keep it as supported but non-core; more specific cell-type proliferation
        terms and the core ligand/receptor-binding function are more informative.
  - term:
      id: GO:0009611
      label: response to wounding
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: >-
        response to wounding is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of
            platelet-derived growth factor leading to inhibition of P43 and P20
            phosphorylation.
      reason: >-
        Response to wounding is a supported physiological context for platelet-derived PDGF-BB
        release and signaling, but is non-core relative to the receptor-ligand function.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: >-
        cell surface is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A and B
            forms of PDGF.
      reason: >-
        Cell surface association is compatible with PDGF receptor binding and heparan-sulfate
        retention, but extracellular region/matrix are more precise mature ligand locations.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:291037
    review:
      summary: >-
        cell surface is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:291037
          supporting_text: 'Platelet-derived growth factor: purification and partial characterization.'
      reason: >-
        Cell surface association is compatible with PDGF receptor binding and heparan-sulfate
        retention, but extracellular region/matrix are more precise mature ligand locations.
  - term:
      id: GO:0010512
      label: negative regulation of phosphatidylinositol biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: >-
        negative regulation of phosphatidylinositol biosynthetic process is supported or plausible
        for PDGFB but represents a context-specific localization, storage, processing, or
        downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of
            platelet-derived growth factor leading to inhibition of P43 and P20
            phosphorylation.
      reason: >-
        The platelet phosphoinositide effect is a specific downstream platelet-feedback context,
        not a core PDGFB function.
  - term:
      id: GO:0010544
      label: negative regulation of platelet activation
    evidence_type: IDA
    original_reference_id: PMID:2538439
    review:
      summary: >-
        negative regulation of platelet activation is supported or plausible for PDGFB but
        represents a context-specific localization, storage, processing, or downstream biological
        outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:2538439
          supporting_text: Collagen-induced binding to human platelets of
            platelet-derived growth factor leading to inhibition of P43 and P20
            phosphorylation.
      reason: >-
        Negative regulation of platelet activation is a specific platelet-feedback context,
        not the core PDGFB ligand function.
  - term:
      id: GO:0042803
      label: protein homodimerization activity
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: >-
        protein homodimerization activity is supported for PDGFB in the context of its mature
        extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A and B
            forms of PDGF.
      reason: >-
        Protein homodimerization activity directly captures PDGF-BB homodimer formation, a
        core biochemical property of the mature ligand.
  - term:
      id: GO:0046982
      label: protein heterodimerization activity
    evidence_type: IPI
    original_reference_id: PMID:7073684
    review:
      summary: >-
        protein heterodimerization activity is supported for PDGFB in the context of its mature
        extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
      reason: >-
        Protein heterodimerization activity captures PDGF-AB formation between PDGFA and PDGFB,
        a recognized active PDGF ligand dimer.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human
            osteosarcoma cells but does not stimulate cell replication.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0048008
      label: platelet-derived growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2836953
    review:
      summary: >-
        platelet-derived growth factor receptor signaling pathway is supported for PDGFB in
        the context of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:2836953
          supporting_text: A common PDGF receptor is activated by homodimeric A and B
            forms of PDGF.
      reason: >-
        PDGF receptor signaling pathway is the core biological process initiated by PDGFB
        ligand binding to PDGFRA/PDGFRB receptor complexes.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:2439522
    review:
      summary: >-
        positive regulation of fibroblast proliferation is supported as a PDGF-B/PDGFR-dependent
        cell-type or chemotaxis process.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:2439522
          supporting_text: PDGF induces c-myc mRNA expression in MG-63 human
            osteosarcoma cells but does not stimulate cell replication.
      reason: >-
        Accept. fibroblast proliferation is a supported biological process downstream of PDGF-B-containing
        ligand signaling and is sufficiently specific to retain for PDGFB.
  - term:
      id: GO:0048407
      label: platelet-derived growth factor binding
    evidence_type: IPI
    original_reference_id: PMID:7073684
    review:
      summary: >-
        platelet-derived growth factor binding is supported for PDGFB in the context of its
        mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:7073684
          supporting_text: 'Platelet-derived growth factor: identification of constituent
            polypeptide chains.'
      reason: >-
        Platelet-derived growth factor binding is consistent with PDGFB participation in PDGF
        dimer formation and PDGF ligand complexes, although the more informative core terms
        are PDGF receptor binding and dimerization.
  - term:
      id: GO:0001938
      label: positive regulation of endothelial cell proliferation
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: >-
        positive regulation of endothelial cell proliferation is retained as a non-core, context-specific
        PDGFB annotation pending more specific upstream curation.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth
            factor-induced vascular smooth muscle cell migration and proliferation by
            suppressing signal transduction and preventing cell entry to G1 phase.
      reason: >-
        The annotation is connected to PDGFB biology, but the core function is extracellular
        PDGF receptor ligand activity and PDGF receptor signaling.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: >-
        cell surface is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth
            factor-induced vascular smooth muscle cell migration and proliferation by
            suppressing signal transduction and preventing cell entry to G1 phase.
      reason: >-
        Cell surface association is compatible with PDGF receptor binding and heparan-sulfate
        retention, but extracellular region/matrix are more precise mature ligand locations.
  - term:
      id: GO:0043536
      label: positive regulation of blood vessel endothelial cell migration
    evidence_type: IDA
    original_reference_id: PMID:9685360
    review:
      summary: >-
        positive regulation of blood vessel endothelial cell migration is retained as a non-core,
        context-specific PDGFB annotation pending more specific upstream curation.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:9685360
          supporting_text: Apolipoprotein E inhibits platelet-derived growth
            factor-induced vascular smooth muscle cell migration and proliferation by
            suppressing signal transduction and preventing cell entry to G1 phase.
      reason: >-
        The annotation is connected to PDGFB biology, but the core function is extracellular
        PDGF receptor ligand activity and PDGF receptor signaling.
  - term:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    evidence_type: NAS
    original_reference_id: PMID:1661670
    review:
      summary: >-
        platelet-derived growth factor receptor binding is supported for PDGFB in the context
        of its mature extracellular PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:1661670
          supporting_text: Two PDGF-B chain residues, arginine 27 and isoleucine 30,
            mediate receptor binding and activation.
      reason: >-
        PDGF receptor binding is a defining molecular function for PDGF-B-containing ligands.
        PDGF-BB and PDGF-AB bind PDGFRA/PDGFRB receptor dimers extracellularly and initiate
        PDGF receptor signaling.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: NAS
    original_reference_id: PMID:1661670
    review:
      summary: >-
        extracellular region is supported for PDGFB in the context of its mature extracellular
        PDGF ligand function.
      action: ACCEPT
      supported_by:
        - reference_id: PMID:1661670
          supporting_text: Two PDGF-B chain residues, arginine 27 and isoleucine 30,
            mediate receptor binding and activation.
      reason: >-
        Extracellular region is strongly supported for mature PDGFB, which is secreted and
        acts as an extracellular receptor ligand.
  - term:
      id: GO:0009611
      label: response to wounding
    evidence_type: NAS
    original_reference_id: PMID:1661670
    review:
      summary: >-
        response to wounding is supported or plausible for PDGFB but represents a context-specific
        localization, storage, processing, or downstream biological outcome.
      action: KEEP_AS_NON_CORE
      supported_by:
        - reference_id: PMID:1661670
          supporting_text: Two PDGF-B chain residues, arginine 27 and isoleucine 30,
            mediate receptor binding and activation.
      reason: >-
        Response to wounding is a supported physiological context for platelet-derived PDGF-BB
        release and signaling, but is non-core relative to the receptor-ligand function.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with GO
      terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data to
      orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
      vocabulary mapping, accompanied by conservative changes to GO terms applied by
      UniProt
    findings: []
  - id: GO_REF:0000108
    title: Automatic assignment of GO terms using logical inference, based on on
      inter-ontology links
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10644978
    title: PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis.
    findings: []
  - id: PMID:10734101
    title: Platelet-derived growth factor receptor beta regulates migration and DNA
      synthesis in metanephric mesenchymal cells.
    findings: []
  - id: PMID:10806482
    title: PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
    findings: []
  - id: PMID:11264163
    title: Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and
      PDGF beta-receptor null mice.
    findings: []
  - id: PMID:11297552
    title: Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds
      to PDGF alpha and beta receptor.
    findings: []
  - id: PMID:11788434
    title: Effect of platelet-derived growth factor isoforms in rat metanephric
      mesenchymal cells.
    findings: []
  - id: PMID:12070119
    title: Adipocyte-derived plasma protein adiponectin acts as a platelet-derived
      growth factor-BB-binding protein and regulates growth factor-induced common
      postreceptor signal in vascular smooth muscle cell.
    findings: []
  - id: PMID:1396586
    title: Crystal structure of human platelet-derived growth factor BB.
    findings: []
  - id: PMID:16014047
    title: Hypoxia regulates PDGF-B interactions between glomerular capillary
      endothelial and mesangial cells.
    findings: []
  - id: PMID:16477012
    title: Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta
      in phenotypic modulation of human aortic smooth muscle cells.
    findings: []
  - id: PMID:16530387
    title: c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA
      synthesis in mesangial cells.
    findings: []
  - id: PMID:1661670
    title: Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor
      binding and activation.
    findings: []
  - id: PMID:17324121
    title: 'Growth factor regulation of hyaluronan synthesis and degradation in human dermal
      fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.'
    findings: []
  - id: PMID:17942966
    title: Mitogenic signaling via platelet-derived growth factor beta in metanephric
      mesenchymal cells.
    findings: []
  - id: PMID:17981115
    title: Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without
      affecting healthy vessels.
    findings: []
  - id: PMID:17991872
    title: 'TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different
      cell types: involvement of Src and PLC.'
    findings: []
  - id: PMID:19019919
    title: PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by
      PDGF AA.
    findings: []
  - id: PMID:19088079
    title: Induction of microRNA-221 by platelet-derived growth factor signaling is
      critical for modulation of vascular smooth muscle phenotype.
    findings: []
  - id: PMID:19126672
    title: Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and
      random migration of fibroblasts.
    findings: []
  - id: PMID:20534510
    title: Structures of a platelet-derived growth factor/propeptide complex and a
      platelet-derived growth factor/receptor complex.
    findings: []
  - id: PMID:21245381
    title: Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential
      for growth factor-dependent migration of glioma and endothelial cells.
    findings: []
  - id: PMID:21321938
    title: Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates
      human saphenous vein smooth muscle cell proliferation.
    findings: []
  - id: PMID:23139410
    title: Unique motifs and hydrophobic interactions shape the binding of modified DNA
      ligands to protein targets.
    findings: []
  - id: PMID:23554459
    title: MicroRNA-638 is highly expressed in human vascular smooth muscle cells and
      inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan
      nuclear receptor NOR1.
    findings: []
  - id: PMID:23979707
    title: SILAC-based proteomics of human primary endothelial cell morphogenesis
      unveils tumor angiogenic markers.
    findings: []
  - id: PMID:24008408
    title: CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis.
    findings: []
  - id: PMID:2439522
    title: PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does
      not stimulate cell replication.
    findings: []
  - id: PMID:25089138
    title: miR-18a-5p MicroRNA Increases Vascular Smooth Muscle Cell Differentiation by
      Downregulating Syndecan4.
    findings: []
  - id: PMID:2536956
    title: Isolation of a novel receptor cDNA establishes the existence of two PDGF
      receptor genes.
    findings: []
  - id: PMID:2538439
    title: Collagen-induced binding to human platelets of platelet-derived growth factor
      leading to inhibition of P43 and P20 phosphorylation.
    findings: []
  - id: PMID:26493107
    title: miRNA-34a reduces neointima formation through inhibiting smooth muscle cell
      proliferation and migration.
    findings: []
  - id: PMID:2836953
    title: A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
    findings: []
  - id: PMID:291037
    title: 'Platelet-derived growth factor: purification and partial characterization.'
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:7073684
    title: 'Platelet-derived growth factor: identification of constituent polypeptide chains.'
    findings: []
  - id: PMID:7679113
    title: Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to
      alpha and beta PDGF receptor.
    findings: []
  - id: PMID:8900172
    title: Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for
      the isoforms of platelet-derived growth factor (AA, BB, and AB).
    findings: []
  - id: PMID:9409235
    title: Platelet-derived growth factor beta-receptors can both promote and inhibit
      chemotaxis in human vascular smooth muscle cells.
    findings: []
  - id: PMID:9685360
    title: Apolipoprotein E inhibits platelet-derived growth factor-induced vascular
      smooth muscle cell migration and proliferation by suppressing signal transduction
      and preventing cell entry to G1 phase.
    findings: []
  - id: Reactome:R-HSA-1524182
    title: Activated PLC gamma dissociates from the PDGF receptor
    findings: []
  - id: Reactome:R-HSA-1524186
    title: Phosphorylation of PLCgamma by PDGFR
    findings: []
  - id: Reactome:R-HSA-186765
    title: PLC-gamma binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186773
    title: PDGF dimer binds two receptors simultaneously
    findings: []
  - id: Reactome:R-HSA-186778
    title: SHP2 binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186780
    title: PI3-kinase binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186786
    title: Autophosphorylation of PDGF beta receptors
    findings: []
  - id: Reactome:R-HSA-186798
    title: GAP binds to PDGF-beta receptors only
    findings: []
  - id: Reactome:R-HSA-186800
    title: PI3K catalyses the phosphorylation of PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-186819
    title: SH2 domain of Src binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186826
    title: GRB2:SOS1 complex binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-186834
    title: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
    findings: []
  - id: Reactome:R-HSA-2316434
    title: PI3K phosphorylates PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-2396337
    title: HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA
      homodimer, PDGFB homodimer
    findings: []
  - id: Reactome:R-HSA-2400009
    title: PI3K inhibitors block PI3K catalytic activity
    findings: []
  - id: Reactome:R-HSA-380780
    title: Activation of Src
    findings: []
  - id: Reactome:R-HSA-380782
    title: STAT binds to the active receptor
    findings: []
  - id: Reactome:R-HSA-382052
    title: p130Cas and C3G bind PDGFR bound Crk
    findings: []
  - id: Reactome:R-HSA-382053
    title: Translocation of PDGF from ER to Golgi
    findings: []
  - id: Reactome:R-HSA-382054
    title: PDGF binds to extracellular matrix proteins
    findings: []
  - id: Reactome:R-HSA-382055
    title: Grb7 binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-382056
    title: Crk binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-382058
    title: Nck binds to the active PDGF receptor
    findings: []
  - id: Reactome:R-HSA-389083
    title: Autophosphorylation of PDGF alpha receptors
    findings: []
  - id: Reactome:R-HSA-389086
    title: Autophosphorylation of PDGF alpha/beta receptors
    findings: []
  - id: Reactome:R-HSA-481007
    title: Exocytosis of platelet alpha granule contents
    findings: []
  - id: Reactome:R-HSA-5672965
    title: RAS GEFs promote RAS nucleotide exchange
    findings: []
  - id: Reactome:R-HSA-8864036
    title: PTPN12 dephosphorylates PDGFRB at Y1021
    findings: []
  - id: Reactome:R-HSA-8865275
    title: PDGF-BB clevage by Furin
    findings: []
  - id: Reactome:R-HSA-8865276
    title: PDGF-AB clevage by Furin
    findings: []
  - id: Reactome:R-HSA-9674093
    title: PDGFRs bind type I TKI
    findings: []
  - id: file:human/PDGFB/PDGFB-deep-research-falcon.md
    title: Falcon deep research report on PDGFB
    findings:
      - statement: >-
          PDGFB is a secreted PDGF ligand whose core GO-relevant evidence is receptor binding,
          growth factor activity, dimerization, extracellular localization, and ligand-attributable
          vascular/mural-cell processes.
        supporting_text: >-
          This report summarizes **GO-relevant evidence for PDGFB as a secreted PDGF ligand**:
          disulfide-linked dimer formation (PDGF‑BB; PDGF‑AB), **direct binding/activation
          of PDGF receptor dimers (PDGFRA/PDGFRB)**, secretion/localization (extracellular
          space; ER/Golgi processing; ECM/HS retention), platelet α‑granule localization (only
          where explicitly stated), and **ligand-attributable biological processes** (pericyte
          recruitment/coverage; angiogenesis/blood vessel morphogenesis; limited wound-healing
          evidence). It **excludes** receptor **intrinsic kinase activity** (peptidyl-tyrosine
          phosphorylation), downstream pathway terms (PI3K–AKT, ERK/MAPK, ROS/NADPH oxidase),
          and broad transcriptional/miRNA effects unless strictly necessary to interpret ligand
          localization or binding (ostman1992pdgfaaandpdgfbb pages 1-2, fredriksson2004thepdgffamily
          pages 5-7).
      - statement: >-
          PDGFB should not be annotated with receptor tyrosine kinase activity or generic
          downstream PI3K/AKT, ERK/MAPK, ROS, or transcriptional outputs as core functions.
        supporting_text: >-
          Do **not** annotate PDGFB with receptor enzymatic activities (e.g., **protein tyrosine
          kinase activity**, **peptidyl-tyrosine phosphorylation**) or generic downstream
          pathways (PI3K/AKT, ERK/MAPK, ROS) based solely on PDGFR signaling descriptions;
          these belong to PDGF receptors or downstream effectors, not the PDGFB ligand itself
          (fredriksson2004thepdgffamily pages 5-7, strell2024functionalandclinical pages 3-5).
  - id: file:human/PDGFB/PDGFB-uniprot.txt
    title: UniProtKB P01127 record for PDGFB
    findings: []
core_functions:
  - molecular_function:
      id: GO:0005161
      label: platelet-derived growth factor receptor binding
    description: >-
      PDGFB is the platelet-derived growth factor B-chain ligand subunit. After secretory-pathway
      processing and disulfide-linked dimer formation, PDGF-B-containing ligands act extracellularly
      as receptor ligands/growth factors for PDGFRA- and PDGFRB-containing receptor dimers.
      This function underlies PDGF receptor signaling, paracrine mural-cell/pericyte recruitment,
      angiogenesis/blood vessel morphogenesis, chemotaxis, and specific smooth muscle/mesenchymal
      proliferation or migration responses. Receptor autophosphorylation and downstream PI3K,
      ERK/MAPK, ROS, and transcriptional outputs are consequences in responding cells rather
      than direct PDGFB molecular functions.
    directly_involved_in:
      - id: GO:0048008
        label: platelet-derived growth factor receptor signaling pathway
      - id: GO:0038001
        label: paracrine signaling
      - id: GO:0001525
        label: angiogenesis
      - id: GO:0060326
        label: cell chemotaxis
    locations:
      - id: GO:0005576
        label: extracellular region
      - id: GO:0031012
        label: extracellular matrix
    supported_by:
      - reference_id: file:human/PDGFB/PDGFB-deep-research-falcon.md
        supporting_text: >-
          This report summarizes **GO-relevant evidence for PDGFB as a secreted PDGF ligand**:
          disulfide-linked dimer formation (PDGF‑BB; PDGF‑AB), **direct binding/activation
          of PDGF receptor dimers (PDGFRA/PDGFRB)**, secretion/localization (extracellular
          space; ER/Golgi processing; ECM/HS retention), platelet α‑granule localization (only
          where explicitly stated), and **ligand-attributable biological processes** (pericyte
          recruitment/coverage; angiogenesis/blood vessel morphogenesis; limited wound-healing
          evidence). It **excludes** receptor **intrinsic kinase activity** (peptidyl-tyrosine
          phosphorylation), downstream pathway terms (PI3K–AKT, ERK/MAPK, ROS/NADPH oxidase),
          and broad transcriptional/miRNA effects unless strictly necessary to interpret ligand
          localization or binding (ostman1992pdgfaaandpdgfbb pages 1-2, fredriksson2004thepdgffamily
          pages 5-7).
      - reference_id: file:human/PDGFB/PDGFB-deep-research-falcon.md
        supporting_text: >-
          PDGF‑AA/AB/BB are described as **secreted in active form**, supporting extracellular
          localization of mature PDGF‑B-containing ligands (duran2018molecularregulationof
          pages 9-11).
proposed_new_terms: []
suggested_questions: []
suggested_experiments: []