PICK1

UniProt ID: Q9NRD5
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for PICK1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0043113 receptor clustering
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006886 intracellular protein transport
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043005 neuron projection
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005543 phospholipid binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008021 synaptic vesicle
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0014069 postsynaptic density
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032588 trans-Golgi network membrane
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097062 dendritic spine maintenance
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002092 positive regulation of receptor internalization
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005080 protein kinase C binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003779 actin binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005856 cytoskeleton
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0014069 postsynaptic density
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019904 protein domain specific binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043005 neuron projection
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045202 synapse
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046872 metal ion binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:11343649
Functional interaction between monoamine plasma membrane tra... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11343649
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
GO:0005515 protein binding
IPI
PMID:11802773
Interaction of the synaptic protein PICK1 (protein interacti... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11802773
Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).
GO:0005515 protein binding
IPI
PMID:16713569
A protein-protein interaction network for human inherited at... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16713569
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
GO:0005515 protein binding
IPI
PMID:21653829
Protein interactome reveals converging molecular pathways am... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21653829
Protein interactome reveals converging molecular pathways among autism disorders.
GO:0005515 protein binding
IPI
PMID:26787460
Proteomic peptide phage display uncovers novel interactions ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:26787460
Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin.
GO:0005515 protein binding
IPI
PMID:28514442
Architecture of the human interactome defines protein commun... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:28514442
Architecture of the human interactome defines protein communities and disease networks.
GO:0005515 protein binding
IPI
PMID:31413325
HENA, heterogeneous network-based data set for Alzheimer's d... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31413325
HENA, heterogeneous network-based data set for Alzheimer's disease.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32296183
Apr 8. A reference map of the human binary protein interactome.
GO:0005515 protein binding
IPI
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:33961781
2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GO:0005515 protein binding
IPI
PMID:36115835
Quantitative fragmentomics allow affinity mapping of interac... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:36115835
Quantitative fragmentomics allow affinity mapping of interactomes.
GO:0005515 protein binding
IPI
PMID:37207277
Using brain cell-type-specific protein interactomes to inter... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:37207277
eCollection 2023 May 19.
GO:0042802 identical protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32296183
Apr 8. A reference map of the human binary protein interactome.
GO:0005829 cytosol
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16314870
Serine racemase binds to PICK1: potential relevance to schiz... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16314870
Serine racemase binds to PICK1: potential relevance to schizophrenia.
GO:0050796 regulation of insulin secretion
IMP
PMID:29768204
An Amphipathic Helix Directs Cellular Membrane Curvature Sen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:29768204
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.
GO:0140090 membrane curvature sensor activity
IDA
PMID:29768204
An Amphipathic Helix Directs Cellular Membrane Curvature Sen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:29768204
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.
GO:0001664 G protein-coupled receptor binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019904 protein domain specific binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002092 positive regulation of receptor internalization
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0021782 glial cell development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036294 cellular response to decreased oxygen levels
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042149 cellular response to glucose starvation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043005 neuron projection
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051015 actin filament binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060292 long-term synaptic depression
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071933 Arp2/3 complex binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097061 dendritic spine organization
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097062 dendritic spine maintenance
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-416639 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-416985 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-421007 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030666 endocytic vesicle membrane
TAS
Reactome:R-HSA-416639 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030666 endocytic vesicle membrane
TAS
Reactome:R-HSA-421007 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:16314870
Serine racemase binds to PICK1: potential relevance to schiz... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16314870
Serine racemase binds to PICK1: potential relevance to schizophrenia.
GO:0005102 signaling receptor binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043113 receptor clustering
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045202 synapse
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005080 protein kinase C binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation
ISS
GO_REF:0000024 		REMOVE
Summary: MISANNOTATION: PICK1 (Protein interacting with C kinase 1) is NOT a kinase. It is a PDZ domain scaffold/adapter protein that BINDS protein kinase C (has GO:0005080 "protein kinase C binding"). UniProt describes it as a "Probable adapter protein that bind to and organize" signaling complexes. PICK1 is also a phosphorylation SUBSTRATE - "Phosphorylation at Thr-82 appears to inhibit the interaction" with GluR2. The ISS evidence is invalid as PICK1 has no kinase domain and doesn't catalyze phosphorylation.
GO:0005737 cytoplasm
IDA
PMID:11343649
Functional interaction between monoamine plasma membrane tra... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11343649
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
GO:0005886 plasma membrane
IDA
PMID:11343649
Functional interaction between monoamine plasma membrane tra... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11343649
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
GO:0015844 monoamine transport
IDA
PMID:11343649
Functional interaction between monoamine plasma membrane tra... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11343649
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
GO:0042734 presynaptic membrane
IDA
PMID:11343649
Functional interaction between monoamine plasma membrane tra... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11343649
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
GO:0045161 neuronal ion channel clustering
TAS
PMID:11343649
Functional interaction between monoamine plasma membrane tra... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11343649
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:11343649
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
PMID:11802773
Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).
PMID:16314870
Serine racemase binds to PICK1: potential relevance to schizophrenia.
PMID:16713569
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
PMID:21653829
Protein interactome reveals converging molecular pathways among autism disorders.
PMID:26787460
Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin.
PMID:28514442
Architecture of the human interactome defines protein communities and disease networks.
PMID:29768204
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.
PMID:31413325
HENA, heterogeneous network-based data set for Alzheimer's disease.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:36115835
Quantitative fragmentomics allow affinity mapping of interactomes.
PMID:37207277
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Reactome:R-HSA-416639
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
Reactome:R-HSA-416985
Trafficking of GluR2-containing AMPA receptors to synapse
Reactome:R-HSA-421007
Endocytosis of Ca impermeable AMPA receptors

📄 View Raw YAML

 
id: Q9NRD5
gene_symbol: PICK1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for PICK1'
alternative_products:
  - name: '1'
    id: Q9NRD5-1
  - name: '2'
    id: Q9NRD5-2
    sequence_note: VSP_054902, VSP_054903
existing_annotations:
  - term:
      id: GO:0043113
      label: receptor clustering
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006886
      label: intracellular protein transport
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043005
      label: neuron projection
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005543
      label: phospholipid binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008021
      label: synaptic vesicle
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014069
      label: postsynaptic density
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032588
      label: trans-Golgi network membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097062
      label: dendritic spine maintenance
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002092
      label: positive regulation of receptor internalization
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005080
      label: protein kinase C binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034315
      label: regulation of Arp2/3 complex-mediated actin nucleation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003779
      label: actin binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005856
      label: cytoskeleton
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014069
      label: postsynaptic density
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019904
      label: protein domain specific binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043005
      label: neuron projection
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045202
      label: synapse
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048471
      label: perinuclear region of cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11343649
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11343649
          supporting_text: Functional interaction between monoamine plasma 
            membrane transporters and the synaptic PDZ domain-containing protein
            PICK1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11802773
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11802773
          supporting_text: Interaction of the synaptic protein PICK1 (protein 
            interacting with C kinase 1) with the non-voltage gated sodium 
            channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion 
            channel).
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16713569
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16713569
          supporting_text: A protein-protein interaction network for human 
            inherited ataxias and disorders of Purkinje cell degeneration.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21653829
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21653829
          supporting_text: Protein interactome reveals converging molecular 
            pathways among autism disorders.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26787460
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26787460
          supporting_text: Proteomic peptide phage display uncovers novel 
            interactions of the PDZ1-2 supramodule of syntenin.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:28514442
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28514442
          supporting_text: Architecture of the human interactome defines protein
            communities and disease networks.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31413325
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31413325
          supporting_text: HENA, heterogeneous network-based data set for 
            Alzheimer's disease.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32814053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32814053
          supporting_text: Interactome Mapping Provides a Network of 
            Neurodegenerative Disease Proteins and Uncovers Widespread Protein 
            Aggregation in Affected Brains.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:36115835
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:36115835
          supporting_text: Quantitative fragmentomics allow affinity mapping of 
            interactomes.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:37207277
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:37207277
          supporting_text: eCollection 2023 May 19.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16314870
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16314870
          supporting_text: 'Serine racemase binds to PICK1: potential relevance to
            schizophrenia.'
  - term:
      id: GO:0050796
      label: regulation of insulin secretion
    evidence_type: IMP
    original_reference_id: PMID:29768204
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29768204
          supporting_text: An Amphipathic Helix Directs Cellular Membrane 
            Curvature Sensing and Function of the BAR Domain Protein PICK1.
  - term:
      id: GO:0140090
      label: membrane curvature sensor activity
    evidence_type: IDA
    original_reference_id: PMID:29768204
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29768204
          supporting_text: An Amphipathic Helix Directs Cellular Membrane 
            Curvature Sensing and Function of the BAR Domain Protein PICK1.
  - term:
      id: GO:0001664
      label: G protein-coupled receptor binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019904
      label: protein domain specific binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002092
      label: positive regulation of receptor internalization
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0021782
      label: glial cell development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034316
      label: negative regulation of Arp2/3 complex-mediated actin nucleation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036294
      label: cellular response to decreased oxygen levels
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042149
      label: cellular response to glucose starvation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043005
      label: neuron projection
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051015
      label: actin filament binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060292
      label: long-term synaptic depression
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071933
      label: Arp2/3 complex binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097061
      label: dendritic spine organization
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097062
      label: dendritic spine maintenance
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-416639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-416985
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-421007
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030666
      label: endocytic vesicle membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-416639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030666
      label: endocytic vesicle membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-421007
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:16314870
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16314870
          supporting_text: 'Serine racemase binds to PICK1: potential relevance to
            schizophrenia.'
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043113
      label: receptor clustering
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045202
      label: synapse
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005080
      label: protein kinase C binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048471
      label: perinuclear region of cytoplasm
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005794
      label: Golgi apparatus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        MISANNOTATION: PICK1 (Protein interacting with C kinase 1) is NOT a kinase.
        It is a PDZ domain scaffold/adapter protein that BINDS protein kinase C
        (has GO:0005080 "protein kinase C binding"). UniProt describes it as a
        "Probable adapter protein that bind to and organize" signaling complexes.
        PICK1 is also a phosphorylation SUBSTRATE - "Phosphorylation at Thr-82
        appears to inhibit the interaction" with GluR2. The ISS evidence is invalid
        as PICK1 has no kinase domain and doesn't catalyze phosphorylation.
      action: REMOVE
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:11343649
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11343649
          supporting_text: Functional interaction between monoamine plasma 
            membrane transporters and the synaptic PDZ domain-containing protein
            PICK1.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:11343649
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11343649
          supporting_text: Functional interaction between monoamine plasma 
            membrane transporters and the synaptic PDZ domain-containing protein
            PICK1.
  - term:
      id: GO:0015844
      label: monoamine transport
    evidence_type: IDA
    original_reference_id: PMID:11343649
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11343649
          supporting_text: Functional interaction between monoamine plasma 
            membrane transporters and the synaptic PDZ domain-containing protein
            PICK1.
  - term:
      id: GO:0042734
      label: presynaptic membrane
    evidence_type: IDA
    original_reference_id: PMID:11343649
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11343649
          supporting_text: Functional interaction between monoamine plasma 
            membrane transporters and the synaptic PDZ domain-containing protein
            PICK1.
  - term:
      id: GO:0045161
      label: neuronal ion channel clustering
    evidence_type: TAS
    original_reference_id: PMID:11343649
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11343649
          supporting_text: Functional interaction between monoamine plasma 
            membrane transporters and the synaptic PDZ domain-containing protein
            PICK1.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:11343649
    title: Functional interaction between monoamine plasma membrane transporters
      and the synaptic PDZ domain-containing protein PICK1.
    findings: []
  - id: PMID:11802773
    title: Interaction of the synaptic protein PICK1 (protein interacting with C
      kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ 
      channel 1) and ASIC (acid-sensing ion channel).
    findings: []
  - id: PMID:16314870
    title: 'Serine racemase binds to PICK1: potential relevance to schizophrenia.'
    findings: []
  - id: PMID:16713569
    title: A protein-protein interaction network for human inherited ataxias and
      disorders of Purkinje cell degeneration.
    findings: []
  - id: PMID:21653829
    title: Protein interactome reveals converging molecular pathways among 
      autism disorders.
    findings: []
  - id: PMID:26787460
    title: Proteomic peptide phage display uncovers novel interactions of the 
      PDZ1-2 supramodule of syntenin.
    findings: []
  - id: PMID:28514442
    title: Architecture of the human interactome defines protein communities and
      disease networks.
    findings: []
  - id: PMID:29768204
    title: An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and 
      Function of the BAR Domain Protein PICK1.
    findings: []
  - id: PMID:31413325
    title: HENA, heterogeneous network-based data set for Alzheimer's disease.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:32814053
    title: Interactome Mapping Provides a Network of Neurodegenerative Disease 
      Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:36115835
    title: Quantitative fragmentomics allow affinity mapping of interactomes.
    findings: []
  - id: PMID:37207277
    title: Using brain cell-type-specific protein interactomes to interpret 
      neurodevelopmental genetic signals in schizophrenia.
    findings: []
  - id: Reactome:R-HSA-416639
    title: Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
    findings: []
  - id: Reactome:R-HSA-416985
    title: Trafficking of GluR2-containing AMPA receptors to synapse
    findings: []
  - id: Reactome:R-HSA-421007
    title: Endocytosis of Ca impermeable AMPA receptors
    findings: []