PIK3CD

UniProt ID: O00329
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for PIK3CD

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016477 cell migration
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005942 phosphatidylinositol 3-kinase complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048015 phosphatidylinositol-mediated signaling
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016303 1-phosphatidylinositol-3-kinase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000166 nucleotide binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002250 adaptive immune response
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002376 immune system process
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002443 leukocyte mediated immunity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005524 ATP binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006629 lipid metabolic process
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006935 chemotaxis
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006954 inflammatory response
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007166 cell surface receptor signaling pathway
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010595 positive regulation of endothelial cell migration
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016301 kinase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016303 1-phosphatidylinositol-3-kinase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016740 transferase activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0022603 regulation of anatomical structure morphogenesis
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030154 cell differentiation
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030155 regulation of cell adhesion
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0033031 positive regulation of neutrophil apoptotic process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042113 B cell activation
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045087 innate immune response
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046854 phosphatidylinositol phosphate biosynthetic process
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051094 positive regulation of developmental process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051240 positive regulation of multicellular organismal process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000026 regulation of multicellular organismal development
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21827948
Dynamics of the phosphoinositide 3-kinase p110Ξ΄ interaction ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21827948
Dynamics of the phosphoinositide 3-kinase p110Ξ΄ interaction with p85Ξ± and membranes reveals aspects of regulation distinct from p110Ξ±.
GO:0005515 protein binding
IPI
PMID:22020336
p37Ξ΄ is a new isoform of PI3K p110Ξ΄ that increases cell prol... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22020336
p37Ξ΄ is a new isoform of PI3K p110Ξ΄ that increases cell proliferation and is overexpressed in tumors.
GO:0005515 protein binding
IPI
PMID:24165795
Dominant-activating germline mutations in the gene encoding ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:24165795
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110Ξ΄ result in T cell senescence and human immunodeficiency.
GO:0005515 protein binding
IPI
PMID:28514442
Architecture of the human interactome defines protein commun... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:28514442
Architecture of the human interactome defines protein communities and disease networks.
GO:0005515 protein binding
IPI
PMID:31031754
Case Study: Mechanism for Increased Follicular Helper T Cell... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31031754
Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32296183
Apr 8. A reference map of the human binary protein interactome.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:33961781
2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GO:0005515 protein binding
IPI
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human ce... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:35271311
2022 Mar 11. OpenCell: Endogenous tagging for the cartography of human cellular organization.
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:40205054
Apr 9. Multimodal cell maps as a foundation for structural and functional genomics.
GO:0005829 cytosol
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32606397
PI3K activation is enhanced by FOXM1D binding to p110 and p8... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32606397
PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits.
GO:0031295 T cell costimulation
TAS
Reactome:R-HSA-389356 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
TAS
Reactome:R-HSA-389158 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006955 immune response
NAS
PMID:27616589
PI3KΞ΄ and primary immunodeficiencies. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:27616589
Sep 12. PI3KΞ΄ and primary immunodeficiencies.
GO:0030183 B cell differentiation
NAS
PMID:20200404
The catalytic PI3K isoforms p110gamma and p110delta contribu... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20200404
The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.
GO:0030217 T cell differentiation
NAS
PMID:17371229
The PI3K p110delta controls T-cell development, differentiat... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17371229
The PI3K p110delta controls T-cell development, differentiation and regulation.
GO:0038084 vascular endothelial growth factor signaling pathway
IGI
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogenesis.
GO:0010595 positive regulation of endothelial cell migration
IGI
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogenesis.
GO:0001938 positive regulation of endothelial cell proliferation
IGI
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogenesis.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
IGI
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogenesis.
GO:0045766 positive regulation of angiogenesis
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:1905278 positive regulation of epithelial tube formation
IGI
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogenesis.
GO:0033031 positive regulation of neutrophil apoptotic process
IMP
PMID:25339672
Human IgA Fc receptor FcΞ±RI (CD89) triggers different forms ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25339672
2014 Oct 22. Human IgA Fc receptor FcΞ±RI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
IMP
PMID:25339672
Human IgA Fc receptor FcΞ±RI (CD89) triggers different forms ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25339672
2014 Oct 22. Human IgA Fc receptor FcΞ±RI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
GO:0001779 natural killer cell differentiation
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0001819 positive regulation of cytokine production
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0002250 adaptive immune response
TAS
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.
GO:0002551 mast cell chemotaxis
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0002679 respiratory burst involved in defense response
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0006954 inflammatory response
TAS
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.
GO:0006954 inflammatory response
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0010818 T cell chemotaxis
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0016303 1-phosphatidylinositol-3-kinase activity
TAS
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.
GO:0030101 natural killer cell activation
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0030217 T cell differentiation
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0030593 neutrophil chemotaxis
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0035747 natural killer cell chemotaxis
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0035754 B cell chemotaxis
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0042110 T cell activation
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0042113 B cell activation
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0043303 mast cell degranulation
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
TAS
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.
GO:0045087 innate immune response
TAS
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.
GO:0045087 innate immune response
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0050852 T cell receptor signaling pathway
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0050853 B cell receptor signaling pathway
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0060374 mast cell differentiation
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0072672 neutrophil extravasation
TAS
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signali... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20940048
2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
GO:0010628 positive regulation of gene expression
IMP
PMID:22079609
The catalytic phosphoinositol 3-kinase isoform p110Ξ΄ is requ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22079609
2011 Nov 11. The catalytic phosphoinositol 3-kinase isoform p110Ξ΄ is required for glioma cell migration and invasion.
GO:0030335 positive regulation of cell migration
IMP
PMID:22079609
The catalytic phosphoinositol 3-kinase isoform p110Ξ΄ is requ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22079609
2011 Nov 11. The catalytic phosphoinositol 3-kinase isoform p110Ξ΄ is required for glioma cell migration and invasion.
GO:0005829 cytosol
TAS
Reactome:R-HSA-1676048 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1676109 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9012657 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9021627 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9027275 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9606887 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-2045911 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-2076220 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-2316434 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-2400009 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-388830 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-388832 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-389158 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-508247 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-879917 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-8854905 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-912627 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-914182 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-9606887 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005942 phosphatidylinositol 3-kinase complex
NAS
PMID:9113989
P110delta, a novel phosphoinositide 3-kinase in leukocytes. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9113989
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
GO:0005942 phosphatidylinositol 3-kinase complex
NAS
PMID:9235916
p110delta, a novel phosphatidylinositol 3-kinase catalytic s... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9235916
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.
GO:0006468 protein phosphorylation
NAS
PMID:9113989
P110delta, a novel phosphoinositide 3-kinase in leukocytes. 		MODIFY
Summary: OVER-ANNOTATION: PIK3CD (p110delta) is primarily a LIPID kinase, not a protein kinase. PMID:9113989 explicitly states PIK3CD "displays a broad phosphoinositide lipid substrate specificity" and notably "does not phosphorylate p85" (unlike p110alpha). The paper mentions only "intrinsic autophosphorylation capacity", which is distinct from general protein phosphorylation. PIK3CD has EC 2.7.1.137 (phosphatidylinositol-4,5-bisphosphate 3-kinase) for lipid phosphorylation. The annotation should be to lipid phosphorylation (GO:0046834) or the specific PI3K process, not protein phosphorylation.
Proposed replacements: lipid phosphorylation
Supporting Evidence:
PMID:9113989
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
GO:0007165 signal transduction
NAS
PMID:9113989
P110delta, a novel phosphoinositide 3-kinase in leukocytes. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9113989
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
GO:0016303 1-phosphatidylinositol-3-kinase activity
NAS
PMID:9235916
p110delta, a novel phosphatidylinositol 3-kinase catalytic s... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9235916
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:17290298
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
PMID:17371229
The PI3K p110delta controls T-cell development, differentiation and regulation.
PMID:20200404
The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.
PMID:20940048
Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and function.
PMID:21827948
Dynamics of the phosphoinositide 3-kinase p110Ξ΄ interaction with p85Ξ± and membranes reveals aspects of regulation distinct from p110Ξ±.
PMID:22020336
p37Ξ΄ is a new isoform of PI3K p110Ξ΄ that increases cell proliferation and is overexpressed in tumors.
PMID:22079609
The catalytic phosphoinositol 3-kinase isoform p110Ξ΄ is required for glioma cell migration and invasion.
PMID:24165795
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110Ξ΄ result in T cell senescence and human immunodeficiency.
PMID:25339672
Human IgA Fc receptor FcΞ±RI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
PMID:27616589
PI3KΞ΄ and primary immunodeficiencies.
PMID:28514442
Architecture of the human interactome defines protein communities and disease networks.
PMID:31031754
Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome.
PMID:31915155
PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogenesis.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32606397
PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human cellular organization.
PMID:40205054
Multimodal cell maps as a foundation for structural and functional genomics.
PMID:9113989
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
PMID:9235916
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.
Reactome:R-HSA-1676048
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
Reactome:R-HSA-1676109
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
Reactome:R-HSA-2045911
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
Reactome:R-HSA-2076220
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
Reactome:R-HSA-2316434
PI3K phosphorylates PIP2 to PIP3
Reactome:R-HSA-2400009
PI3K inhibitors block PI3K catalytic activity
Reactome:R-HSA-388830
PI3K binds ICOS
Reactome:R-HSA-388832
PI3K binds CD28
Reactome:R-HSA-389158
CD28 bound PI3K phosphorylates PIP2 to PIP3
Reactome:R-HSA-389356
Co-stimulation by CD28
Reactome:R-HSA-508247
Gab2 binds the p85 subunit of Class 1A PI3 kinases
Reactome:R-HSA-879917
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
Reactome:R-HSA-8854905
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
Reactome:R-HSA-9012657
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
Reactome:R-HSA-9021627
EPOR-associated PI3K phosphorylates PIP2 to PIP3
Reactome:R-HSA-9027275
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
Reactome:R-HSA-912627
CBL ubiquitinates PI3K
Reactome:R-HSA-914182
14-3-3 zeta binding allows recruitment of PI3K
Reactome:R-HSA-9606887
p-CD19:VAV binds PI3K and GRB2

πŸ“„ View Raw YAML

 
id: O00329
gene_symbol: PIK3CD
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for PIK3CD'
alternative_products:
  - name: 1 (p110-delta)
    id: O00329-1
  - name: 2 (p37-delta)
    id: O00329-2
    sequence_note: VSP_044409, VSP_044410
existing_annotations:
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016477
      label: cell migration
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005942
      label: phosphatidylinositol 3-kinase complex
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043491
      label: phosphatidylinositol 3-kinase/protein kinase B signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036092
      label: phosphatidylinositol-3-phosphate biosynthetic process
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048015
      label: phosphatidylinositol-mediated signaling
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016303
      label: 1-phosphatidylinositol-3-kinase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035005
      label: 1-phosphatidylinositol-4-phosphate 3-kinase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000166
      label: nucleotide binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002250
      label: adaptive immune response
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002376
      label: immune system process
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002443
      label: leukocyte mediated immunity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005524
      label: ATP binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005943
      label: phosphatidylinositol 3-kinase complex, class IA
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006629
      label: lipid metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006935
      label: chemotaxis
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006954
      label: inflammatory response
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010595
      label: positive regulation of endothelial cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016301
      label: kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016303
      label: 1-phosphatidylinositol-3-kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016740
      label: transferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0022603
      label: regulation of anatomical structure morphogenesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030154
      label: cell differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030155
      label: regulation of cell adhesion
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033031
      label: positive regulation of neutrophil apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042113
      label: B cell activation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043491
      label: phosphatidylinositol 3-kinase/protein kinase B signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045087
      label: innate immune response
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046854
      label: phosphatidylinositol phosphate biosynthetic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046934
      label: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051094
      label: positive regulation of developmental process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051240
      label: positive regulation of multicellular organismal process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000026
      label: regulation of multicellular organismal development
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21827948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21827948
          supporting_text: Dynamics of the phosphoinositide 3-kinase p110Ξ΄ 
            interaction with p85Ξ± and membranes reveals aspects of regulation 
            distinct from p110Ξ±.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22020336
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22020336
          supporting_text: p37Ξ΄ is a new isoform of PI3K p110Ξ΄ that increases 
            cell proliferation and is overexpressed in tumors.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24165795
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24165795
          supporting_text: Dominant-activating germline mutations in the gene 
            encoding the PI(3)K catalytic subunit p110Ξ΄ result in T cell 
            senescence and human immunodeficiency.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:28514442
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28514442
          supporting_text: Architecture of the human interactome defines protein
            communities and disease networks.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31031754
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31031754
          supporting_text: 'Case Study: Mechanism for Increased Follicular Helper
            T Cell Development in Activated PI3K Delta Syndrome.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:35271311
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:35271311
          supporting_text: '2022 Mar 11. OpenCell: Endogenous tagging for the cartography
            of human cellular organization.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:40205054
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:40205054
          supporting_text: Apr 9. Multimodal cell maps as a foundation for 
            structural and functional genomics.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32606397
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32606397
          supporting_text: PI3K activation is enhanced by FOXM1D binding to p110
            and p85 subunits.
  - term:
      id: GO:0031295
      label: T cell costimulation
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389356
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046934
      label: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389158
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006955
      label: immune response
    evidence_type: NAS
    original_reference_id: PMID:27616589
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27616589
          supporting_text: Sep 12. PI3KΞ΄ and primary immunodeficiencies.
  - term:
      id: GO:0030183
      label: B cell differentiation
    evidence_type: NAS
    original_reference_id: PMID:20200404
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20200404
          supporting_text: The catalytic PI3K isoforms p110gamma and p110delta 
            contribute to B cell development and maintenance, transformation, 
            and proliferation.
  - term:
      id: GO:0030217
      label: T cell differentiation
    evidence_type: NAS
    original_reference_id: PMID:17371229
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17371229
          supporting_text: The PI3K p110delta controls T-cell development, 
            differentiation and regulation.
  - term:
      id: GO:0038084
      label: vascular endothelial growth factor signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:31915155
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31915155
          supporting_text: PI3KΞ΄ as a Novel Therapeutic Target in Pathological 
            Angiogenesis.
  - term:
      id: GO:0010595
      label: positive regulation of endothelial cell migration
    evidence_type: IGI
    original_reference_id: PMID:31915155
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31915155
          supporting_text: PI3KΞ΄ as a Novel Therapeutic Target in Pathological 
            Angiogenesis.
  - term:
      id: GO:0001938
      label: positive regulation of endothelial cell proliferation
    evidence_type: IGI
    original_reference_id: PMID:31915155
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31915155
          supporting_text: PI3KΞ΄ as a Novel Therapeutic Target in Pathological 
            Angiogenesis.
  - term:
      id: GO:0043491
      label: phosphatidylinositol 3-kinase/protein kinase B signal transduction
    evidence_type: IGI
    original_reference_id: PMID:31915155
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31915155
          supporting_text: PI3KΞ΄ as a Novel Therapeutic Target in Pathological 
            Angiogenesis.
  - term:
      id: GO:0045766
      label: positive regulation of angiogenesis
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1905278
      label: positive regulation of epithelial tube formation
    evidence_type: IGI
    original_reference_id: PMID:31915155
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31915155
          supporting_text: PI3KΞ΄ as a Novel Therapeutic Target in Pathological 
            Angiogenesis.
  - term:
      id: GO:0033031
      label: positive regulation of neutrophil apoptotic process
    evidence_type: IMP
    original_reference_id: PMID:25339672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25339672
          supporting_text: 2014 Oct 22. Human IgA Fc receptor FcΞ±RI (CD89) 
            triggers different forms of neutrophil death depending on the 
            inflammatory microenvironment.
  - term:
      id: GO:0043491
      label: phosphatidylinositol 3-kinase/protein kinase B signal transduction
    evidence_type: IMP
    original_reference_id: PMID:25339672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25339672
          supporting_text: 2014 Oct 22. Human IgA Fc receptor FcΞ±RI (CD89) 
            triggers different forms of neutrophil death depending on the 
            inflammatory microenvironment.
  - term:
      id: GO:0001779
      label: natural killer cell differentiation
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0001819
      label: positive regulation of cytokine production
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0002250
      label: adaptive immune response
    evidence_type: TAS
    original_reference_id: PMID:17290298
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17290298
          supporting_text: 'PI3K delta and PI3K gamma: partners in crime in inflammation
            in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.'
  - term:
      id: GO:0002551
      label: mast cell chemotaxis
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0002679
      label: respiratory burst involved in defense response
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0006954
      label: inflammatory response
    evidence_type: TAS
    original_reference_id: PMID:17290298
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17290298
          supporting_text: 'PI3K delta and PI3K gamma: partners in crime in inflammation
            in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.'
  - term:
      id: GO:0006954
      label: inflammatory response
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0010818
      label: T cell chemotaxis
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0016303
      label: 1-phosphatidylinositol-3-kinase activity
    evidence_type: TAS
    original_reference_id: PMID:17290298
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17290298
          supporting_text: 'PI3K delta and PI3K gamma: partners in crime in inflammation
            in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.'
  - term:
      id: GO:0030101
      label: natural killer cell activation
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0030217
      label: T cell differentiation
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0030593
      label: neutrophil chemotaxis
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0035747
      label: natural killer cell chemotaxis
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0035754
      label: B cell chemotaxis
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0042110
      label: T cell activation
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0042113
      label: B cell activation
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0043303
      label: mast cell degranulation
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0043491
      label: phosphatidylinositol 3-kinase/protein kinase B signal transduction
    evidence_type: TAS
    original_reference_id: PMID:17290298
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17290298
          supporting_text: 'PI3K delta and PI3K gamma: partners in crime in inflammation
            in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.'
  - term:
      id: GO:0045087
      label: innate immune response
    evidence_type: TAS
    original_reference_id: PMID:17290298
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17290298
          supporting_text: 'PI3K delta and PI3K gamma: partners in crime in inflammation
            in rheumatoid arthritis and beyond? Rommel C(1), Camps M, Ji H.'
  - term:
      id: GO:0045087
      label: innate immune response
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0050852
      label: T cell receptor signaling pathway
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0050853
      label: B cell receptor signaling pathway
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0060374
      label: mast cell differentiation
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0072672
      label: neutrophil extravasation
    evidence_type: TAS
    original_reference_id: PMID:20940048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20940048
          supporting_text: 2010 Oct 16. Phosphoinositide 3-kinase delta (PI3KΞ΄) 
            in leukocyte signaling and function.
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: IMP
    original_reference_id: PMID:22079609
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22079609
          supporting_text: 2011 Nov 11. The catalytic phosphoinositol 3-kinase 
            isoform p110Ξ΄ is required for glioma cell migration and invasion.
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IMP
    original_reference_id: PMID:22079609
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22079609
          supporting_text: 2011 Nov 11. The catalytic phosphoinositol 3-kinase 
            isoform p110Ξ΄ is required for glioma cell migration and invasion.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1676048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-1676109
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9012657
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9021627
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9027275
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9606887
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2045911
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2076220
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2316434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-2400009
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-388830
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-388832
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389158
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-508247
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-879917
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8854905
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-912627
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-914182
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9606887
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005942
      label: phosphatidylinositol 3-kinase complex
    evidence_type: NAS
    original_reference_id: PMID:9113989
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9113989
          supporting_text: P110delta, a novel phosphoinositide 3-kinase in 
            leukocytes.
  - term:
      id: GO:0005942
      label: phosphatidylinositol 3-kinase complex
    evidence_type: NAS
    original_reference_id: PMID:9235916
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9235916
          supporting_text: p110delta, a novel phosphatidylinositol 3-kinase 
            catalytic subunit that associates with p85 and is expressed 
            predominantly in leukocytes.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: NAS
    original_reference_id: PMID:9113989
    review:
      summary: >-
        OVER-ANNOTATION: PIK3CD (p110delta) is primarily a LIPID kinase, not a protein
        kinase. PMID:9113989 explicitly states PIK3CD "displays a broad phosphoinositide
        lipid substrate specificity" and notably "does not phosphorylate p85" (unlike
        p110alpha). The paper mentions only "intrinsic autophosphorylation capacity",
        which is distinct from general protein phosphorylation. PIK3CD has EC 2.7.1.137
        (phosphatidylinositol-4,5-bisphosphate 3-kinase) for lipid phosphorylation.
        The annotation should be to lipid phosphorylation (GO:0046834) or the specific
        PI3K process, not protein phosphorylation.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0046834
          label: lipid phosphorylation
      supported_by:
        - reference_id: PMID:9113989
          supporting_text: P110delta, a novel phosphoinositide 3-kinase in 
            leukocytes.
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: NAS
    original_reference_id: PMID:9113989
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9113989
          supporting_text: P110delta, a novel phosphoinositide 3-kinase in 
            leukocytes.
  - term:
      id: GO:0016303
      label: 1-phosphatidylinositol-3-kinase activity
    evidence_type: NAS
    original_reference_id: PMID:9235916
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9235916
          supporting_text: p110delta, a novel phosphatidylinositol 3-kinase 
            catalytic subunit that associates with p85 and is expressed 
            predominantly in leukocytes.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:17290298
    title: 'PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid
      arthritis and beyond?'
    findings: []
  - id: PMID:17371229
    title: The PI3K p110delta controls T-cell development, differentiation and 
      regulation.
    findings: []
  - id: PMID:20200404
    title: The catalytic PI3K isoforms p110gamma and p110delta contribute to B 
      cell development and maintenance, transformation, and proliferation.
    findings: []
  - id: PMID:20940048
    title: Phosphoinositide 3-kinase delta (PI3KΞ΄) in leukocyte signaling and 
      function.
    findings: []
  - id: PMID:21827948
    title: Dynamics of the phosphoinositide 3-kinase p110Ξ΄ interaction with p85Ξ±
      and membranes reveals aspects of regulation distinct from p110Ξ±.
    findings: []
  - id: PMID:22020336
    title: p37Ξ΄ is a new isoform of PI3K p110Ξ΄ that increases cell proliferation
      and is overexpressed in tumors.
    findings: []
  - id: PMID:22079609
    title: The catalytic phosphoinositol 3-kinase isoform p110Ξ΄ is required for 
      glioma cell migration and invasion.
    findings: []
  - id: PMID:24165795
    title: Dominant-activating germline mutations in the gene encoding the 
      PI(3)K catalytic subunit p110Ξ΄ result in T cell senescence and human 
      immunodeficiency.
    findings: []
  - id: PMID:25339672
    title: Human IgA Fc receptor FcΞ±RI (CD89) triggers different forms of 
      neutrophil death depending on the inflammatory microenvironment.
    findings: []
  - id: PMID:27616589
    title: PI3KΞ΄ and primary immunodeficiencies.
    findings: []
  - id: PMID:28514442
    title: Architecture of the human interactome defines protein communities and
      disease networks.
    findings: []
  - id: PMID:31031754
    title: 'Case Study: Mechanism for Increased Follicular Helper T Cell Development
      in Activated PI3K Delta Syndrome.'
    findings: []
  - id: PMID:31915155
    title: PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogenesis.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:32606397
    title: PI3K activation is enhanced by FOXM1D binding to p110 and p85 
      subunits.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:35271311
    title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
    findings: []
  - id: PMID:40205054
    title: Multimodal cell maps as a foundation for structural and functional 
      genomics.
    findings: []
  - id: PMID:9113989
    title: P110delta, a novel phosphoinositide 3-kinase in leukocytes.
    findings: []
  - id: PMID:9235916
    title: p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit 
      that associates with p85 and is expressed predominantly in leukocytes.
    findings: []
  - id: Reactome:R-HSA-1676048
    title: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma 
      membrane
    findings: []
  - id: Reactome:R-HSA-1676109
    title: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma 
      membrane
    findings: []
  - id: Reactome:R-HSA-2045911
    title: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
    findings: []
  - id: Reactome:R-HSA-2076220
    title: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
    findings: []
  - id: Reactome:R-HSA-2316434
    title: PI3K phosphorylates PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-2400009
    title: PI3K inhibitors block PI3K catalytic activity
    findings: []
  - id: Reactome:R-HSA-388830
    title: PI3K binds ICOS
    findings: []
  - id: Reactome:R-HSA-388832
    title: PI3K binds CD28
    findings: []
  - id: Reactome:R-HSA-389158
    title: CD28 bound PI3K phosphorylates PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-389356
    title: Co-stimulation by CD28
    findings: []
  - id: Reactome:R-HSA-508247
    title: Gab2 binds the p85 subunit of Class 1A PI3 kinases
    findings: []
  - id: Reactome:R-HSA-879917
    title: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
    findings: []
  - id: Reactome:R-HSA-8854905
    title: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
    findings: []
  - id: Reactome:R-HSA-9012657
    title: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
    findings: []
  - id: Reactome:R-HSA-9021627
    title: EPOR-associated PI3K phosphorylates PIP2 to PIP3
    findings: []
  - id: Reactome:R-HSA-9027275
    title: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
    findings: []
  - id: Reactome:R-HSA-912627
    title: CBL ubiquitinates PI3K
    findings: []
  - id: Reactome:R-HSA-914182
    title: 14-3-3 zeta binding allows recruitment of PI3K
    findings: []
  - id: Reactome:R-HSA-9606887
    title: p-CD19:VAV binds PI3K and GRB2
    findings: []