GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q99570 PIK3R4 involved_in GO:0000425 pexophagy biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000426471|SGD:S000000301 9606 Homo sapiens GO_Central Phosphoinositide 3-kinase regulatory subunit 4 20240528 UniProtKB Q99570 PIK3R4 part_of GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I cellular_component ECO:0000318 IBA GO_REF:0000033 FB:FBgn0260935|PANTHER:PTN000426471|PomBase:SPBC119.07|SGD:S000000301 9606 Homo sapiens GO_Central Phosphoinositide 3-kinase regulatory subunit 4 20200808 UniProtKB Q99570 PIK3R4 part_of GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II cellular_component ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000426471|PomBase:SPBC119.07|SGD:S000000301 9606 Homo sapiens GO_Central Phosphoinositide 3-kinase regulatory subunit 4 20200808 UniProtKB Q99570 PIK3R4 enables GO:0004674 protein serine/threonine kinase activity molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000426471|SGD:S000000301 9606 Homo sapiens GO_Central Phosphoinositide 3-kinase regulatory subunit 4 20170228 UniProtKB Q99570 PIK3R4 is_active_in GO:0005770 late endosome cellular_component ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000426471|UniProtKB:Q99570 9606 Homo sapiens GO_Central Phosphoinositide 3-kinase regulatory subunit 4 20170228 UniProtKB Q99570 PIK3R4 involved_in GO:0006623 protein targeting to vacuole biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000426471|SGD:S000000301 9606 Homo sapiens GO_Central Phosphoinositide 3-kinase regulatory subunit 4 20170228 UniProtKB Q99570 PIK3R4 involved_in GO:0045324 late endosome to vacuole transport biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000426471|SGD:S000000301 9606 Homo sapiens GO_Central Phosphoinositide 3-kinase regulatory subunit 4 20170228 UniProtKB Q99570 PIK3R4 is_active_in GO:0071561 nucleus-vacuole junction cellular_component ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000426471|SGD:S000000301 9606 Homo sapiens GO_Central Phosphoinositide 3-kinase regulatory subunit 4 20170228 UniProtKB Q99570 PIK3R4 enables GO:0004672 protein kinase activity molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000719|InterPro:IPR008271 9606 Homo sapiens InterPro Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 enables GO:0004674 protein serine/threonine kinase activity molecular_function ECO:0000501 IEA GO_REF:0000120 InterPro:IPR045162|EC:2.7.11.1 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 enables GO:0005524 ATP binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000719 9606 Homo sapiens InterPro Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 located_in GO:0005737 cytoplasm cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00026971 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 located_in GO:0005770 late endosome cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0152 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 located_in GO:0005776 autophagosome cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0023 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 located_in GO:0005856 cytoskeleton cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00029228 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 located_in GO:0005929 cilium cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00028353 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 located_in GO:0016020 membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0162 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 involved_in GO:0016236 macroautophagy biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR045162 9606 Homo sapiens InterPro Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 involved_in GO:0045324 late endosome to vacuole transport biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR045162 9606 Homo sapiens InterPro Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 enables GO:0106310 protein serine kinase activity molecular_function ECO:0007322 IEA GO_REF:0000116 RHEA:17989 9606 Homo sapiens RHEA Phosphoinositide 3-kinase regulatory subunit 4 20260428 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:24785657 UniProtKB:Q96F24 9606 Homo sapiens IntAct Phosphoinositide 3-kinase regulatory subunit 4 20260425 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:24849286 UniProtKB:Q96F24 9606 Homo sapiens IntAct Phosphoinositide 3-kinase regulatory subunit 4 20260425 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:28514442 UniProtKB:Q96F24 9606 Homo sapiens IntAct Phosphoinositide 3-kinase regulatory subunit 4 20260425 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q53EP0-3 9606 Homo sapiens IntAct Phosphoinositide 3-kinase regulatory subunit 4 20260425 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q96F24 9606 Homo sapiens IntAct Phosphoinositide 3-kinase regulatory subunit 4 20260425 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32707033 UniProtKB:Q96F24 9606 Homo sapiens IntAct Phosphoinositide 3-kinase regulatory subunit 4 20260425 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:Q96F24 9606 Homo sapiens IntAct Phosphoinositide 3-kinase regulatory subunit 4 20260425 UniProtKB Q99570 PIK3R4 located_in GO:0005930 axoneme cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q8VD65|ensembl:ENSMUSP00000067400 9606 Homo sapiens Ensembl Phosphoinositide 3-kinase regulatory subunit 4 20260422 UniProtKB Q99570 PIK3R4 part_of GO:0035032 phosphatidylinositol 3-kinase complex, class III cellular_component ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00089473|UniProtKB:Q8VD65|ensembl:ENSMUSP00000067400 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20260422 UniProtKB Q99570 PIK3R4 involved_in GO:0042149 cellular response to glucose starvation biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q8VD65|ensembl:ENSMUSP00000067400 9606 Homo sapiens Ensembl Phosphoinositide 3-kinase regulatory subunit 4 20260422 UniProtKB Q99570 PIK3R4 involved_in GO:0006622 protein targeting to lysosome biological_process ECO:0005547 NAS PMID:16467569 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 involved_in GO:0010506 regulation of autophagy biological_process ECO:0000314 IDA PMID:16799551 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 involved_in GO:0016236 macroautophagy biological_process ECO:0005547 NAS PMID:40442316 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 involved_in GO:0016241 regulation of macroautophagy biological_process ECO:0000314 IDA PMID:10625637 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 part_of GO:0035032 phosphatidylinositol 3-kinase complex, class III cellular_component ECO:0000353 IPI PMID:25490155 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 part_of GO:0035032 phosphatidylinositol 3-kinase complex, class III cellular_component ECO:0000353 IPI PMID:40442316 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 involved_in GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process biological_process ECO:0000314 IDA PMID:8999962 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 involved_in GO:0045022 early endosome to late endosome transport biological_process ECO:0000314 IDA PMID:14617358 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 involved_in GO:0097352 autophagosome maturation biological_process ECO:0000314 IDA PMID:10625637 9606 Homo sapiens ComplexPortal Phosphoinositide 3-kinase regulatory subunit 4 20251229 UniProtKB Q99570 PIK3R4 involved_in GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction biological_process ECO:0000314 IDA PMID:21062745 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20230904 UniProtKB Q99570 PIK3R4 located_in GO:0030670 phagocytic vesicle membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-6798174 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150917 UniProtKB Q99570 PIK3R4 involved_in GO:0032465 regulation of cytokinesis biological_process ECO:0000315 IMP PMID:20643123 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20150327 UniProtKB Q99570 PIK3R4 involved_in GO:0032801 receptor catabolic process biological_process ECO:0000315 IMP PMID:20643123 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20150327 UniProtKB Q99570 PIK3R4 part_of GO:0035032 phosphatidylinositol 3-kinase complex, class III cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q8VD65 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20150203 UniProtKB Q99570 PIK3R4 involved_in GO:0042149 cellular response to glucose starvation biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q8VD65 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20150203 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-109699 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1632857 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1675939 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1675961 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1676024 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-188002 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5672012 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5678313 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5678315 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5679205 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5679266 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5682385 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9755359 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9921171 9606 Homo sapiens Reactome Phosphoinositide 3-kinase regulatory subunit 4 20150129 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23878393 UniProtKB:Q14457 9606 Homo sapiens ParkinsonsUK-UCL Phosphoinositide 3-kinase regulatory subunit 4 20150109 UniProtKB Q99570 PIK3R4 located_in GO:0016020 membrane cellular_component ECO:0007005 HDA PMID:19946888 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20140627 UniProtKB Q99570 PIK3R4 located_in GO:0005930 axoneme cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q8VD65 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20131118 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19270696 UniProtKB:Q6ZNE5 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20120708 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:14617358 UniProtKB:P51149 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20120213 UniProtKB Q99570 PIK3R4 located_in GO:0005770 late endosome cellular_component ECO:0000314 IDA PMID:14617358 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20120213 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19270696 UniProtKB:Q14457 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20100625 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19270696 UniProtKB:Q92622 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20100625 UniProtKB Q99570 PIK3R4 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19270696 UniProtKB:Q9P2Y5 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20100625 UniProtKB Q99570 PIK3R4 enables GO:0004672 protein kinase activity molecular_function ECO:0000303 NAS PMID:8999962 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20010919 UniProtKB Q99570 PIK3R4 involved_in GO:0006468 protein phosphorylation biological_process ECO:0000303 NAS PMID:8999962 9606 Homo sapiens UniProt Phosphoinositide 3-kinase regulatory subunit 4 20010919