PPP4R1

UniProt ID: Q8TF05
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for PPP4R1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019888 protein phosphatase regulator activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16085932
A novel, evolutionarily conserved protein phosphatase comple... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16085932
Epub 2005 Aug 5. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
GO:0005515 protein binding
IPI
PMID:17353931
Large-scale mapping of human protein-protein interactions by... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17353931
Large-scale mapping of human protein-protein interactions by mass spectrometry.
GO:0005515 protein binding
IPI
PMID:18614045
A PP4-phosphatase complex dephosphorylates gamma-H2AX genera... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18614045
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
GO:0005515 protein binding
IPI
PMID:18715871
PP4R4/KIAA1622 forms a novel stable cytosolic complex with p... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18715871
2008 Aug 20. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.
GO:0005515 protein binding
IPI
PMID:26496610
A human interactome in three quantitative dimensions organiz... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:26496610
Oct 22. A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
GO:0005515 protein binding
IPI
PMID:27880917
Phenotypic and Interaction Profiling of the Human Phosphatas... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:27880917
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:33961781
2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:40205054
Apr 9. Multimodal cell maps as a foundation for structural and functional genomics.
GO:0004721 phosphoprotein phosphatase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation
ISS
GO_REF:0000024 		REMOVE
Summary: MISANNOTATION - OPPOSITE REACTION: PPP4R1 is the regulatory subunit of protein phosphatase 4 (PP4), which catalyzes DEPHOSPHORYLATION, not phosphorylation! UniProt describes it as "Serine/threonine-protein phosphatase 4 regulatory subunit 1". PMID:18614045 states "A PP4-phosphatase complex dephosphorylates gamma-H2AX". Phosphatases REMOVE phosphate groups, kinases ADD them. This is a fundamental misannotation - the gene should be annotated to dephosphorylation or protein phosphatase activity, not protein phosphorylation.
GO:0030289 protein phosphatase 4 complex
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
NAS
PMID:10026142
Purification and identification of a novel subunit of protei... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10026142
Purification and identification of a novel subunit of protein serine/threonine phosphatase 4.
GO:0019888 protein phosphatase regulator activity
NAS
PMID:10026142
Purification and identification of a novel subunit of protei... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10026142
Purification and identification of a novel subunit of protein serine/threonine phosphatase 4.

References

GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
PMID:10026142
Purification and identification of a novel subunit of protein serine/threonine phosphatase 4.
PMID:16085932
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
PMID:17353931
Large-scale mapping of human protein-protein interactions by mass spectrometry.
PMID:18614045
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
PMID:18715871
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.
PMID:26496610
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
PMID:27880917
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:40205054
Multimodal cell maps as a foundation for structural and functional genomics.

📄 View Raw YAML

 
id: Q8TF05
gene_symbol: PPP4R1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for PPP4R1'
alternative_products:
  - name: 1 (PP4Rmeg)
    id: Q8TF05-1
  - name: '2'
    id: Q8TF05-2
    sequence_note: VSP_009469
existing_annotations:
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019888
      label: protein phosphatase regulator activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16085932
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16085932
          supporting_text: Epub 2005 Aug 5. A novel, evolutionarily conserved 
            protein phosphatase complex involved in cisplatin sensitivity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17353931
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17353931
          supporting_text: Large-scale mapping of human protein-protein 
            interactions by mass spectrometry.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18614045
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18614045
          supporting_text: A PP4-phosphatase complex dephosphorylates gamma-H2AX
            generated during DNA replication.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18715871
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18715871
          supporting_text: 2008 Aug 20. PP4R4/KIAA1622 forms a novel stable 
            cytosolic complex with phosphoprotein phosphatase 4.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26496610
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26496610
          supporting_text: Oct 22. A human interactome in three quantitative 
            dimensions organized by stoichiometries and abundances.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:27880917
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27880917
          supporting_text: Phenotypic and Interaction Profiling of the Human 
            Phosphatases Identifies Diverse Mitotic Regulators.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:40205054
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:40205054
          supporting_text: Apr 9. Multimodal cell maps as a foundation for 
            structural and functional genomics.
  - term:
      id: GO:0004721
      label: phosphoprotein phosphatase activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        MISANNOTATION - OPPOSITE REACTION: PPP4R1 is the regulatory subunit of protein
        phosphatase 4 (PP4), which catalyzes DEPHOSPHORYLATION, not phosphorylation!
        UniProt describes it as "Serine/threonine-protein phosphatase 4 regulatory
        subunit 1". PMID:18614045 states "A PP4-phosphatase complex dephosphorylates
        gamma-H2AX". Phosphatases REMOVE phosphate groups, kinases ADD them. This
        is
        a fundamental misannotation - the gene should be annotated to dephosphorylation
        or protein phosphatase activity, not protein phosphorylation.
      action: REMOVE
  - term:
      id: GO:0030289
      label: protein phosphatase 4 complex
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: NAS
    original_reference_id: PMID:10026142
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10026142
          supporting_text: Purification and identification of a novel subunit of
            protein serine/threonine phosphatase 4.
  - term:
      id: GO:0019888
      label: protein phosphatase regulator activity
    evidence_type: NAS
    original_reference_id: PMID:10026142
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10026142
          supporting_text: Purification and identification of a novel subunit of
            protein serine/threonine phosphatase 4.
references:
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: PMID:10026142
    title: Purification and identification of a novel subunit of protein 
      serine/threonine phosphatase 4.
    findings: []
  - id: PMID:16085932
    title: A novel, evolutionarily conserved protein phosphatase complex 
      involved in cisplatin sensitivity.
    findings: []
  - id: PMID:17353931
    title: Large-scale mapping of human protein-protein interactions by mass 
      spectrometry.
    findings: []
  - id: PMID:18614045
    title: A PP4-phosphatase complex dephosphorylates gamma-H2AX generated 
      during DNA replication.
    findings: []
  - id: PMID:18715871
    title: PP4R4/KIAA1622 forms a novel stable cytosolic complex with 
      phosphoprotein phosphatase 4.
    findings: []
  - id: PMID:26496610
    title: A human interactome in three quantitative dimensions organized by 
      stoichiometries and abundances.
    findings: []
  - id: PMID:27880917
    title: Phenotypic and Interaction Profiling of the Human Phosphatases 
      Identifies Diverse Mitotic Regulators.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:40205054
    title: Multimodal cell maps as a foundation for structural and functional 
      genomics.
    findings: []