PPP4R4

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0004864 protein phosphatase inhibitor activity	IDA PMID:18715871 PP4R4/KIAA1622 forms a novel stable cytosolic complex with p...	KEEP AS NON CORE	Summary: protein phosphatase inhibitor activity: PP4R4-containing complexes showed lower activity toward tested substrates than free PP4c. This supports the experimental inhibitory/regulatory effect in that assay, but not a universal inhibitor role for every physiological PP4 substrate. Reason: PP4R4-containing complexes showed lower activity toward tested substrates than free PP4c. This supports the experimental inhibitory/regulatory effect in that assay, but not a universal inhibitor role for every physiological PP4 substrate. Supporting Evidence: PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.
GO:0004865 protein serine/threonine phosphatase inhibitor activity	IDA PMID:18715871 PP4R4/KIAA1622 forms a novel stable cytosolic complex with p...	KEEP AS NON CORE	Summary: protein serine/threonine phosphatase inhibitor activity: PP4R4-containing complexes showed lower activity toward tested substrates than free PP4c. This supports the experimental inhibitory/regulatory effect in that assay, but not a universal inhibitor role for every physiological PP4 substrate. Reason: PP4R4-containing complexes showed lower activity toward tested substrates than free PP4c. This supports the experimental inhibitory/regulatory effect in that assay, but not a universal inhibitor role for every physiological PP4 substrate. Supporting Evidence: PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.
GO:0005515 protein binding	IPI PMID:18715871 PP4R4/KIAA1622 forms a novel stable cytosolic complex with p...	UNDECIDED	Summary: protein binding: The PMID:18715871 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:18715871 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding	IPI PMID:27880917 Phenotypic and Interaction Profiling of the Human Phosphatas...	UNDECIDED	Summary: protein binding: The PMID:27880917 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:27880917 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding	IPI PMID:28514442 Architecture of the human interactome defines protein commun...	UNDECIDED	Summary: protein binding: The PMID:28514442 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:28514442 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding	IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling...	UNDECIDED	Summary: protein binding: The PMID:33961781 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:33961781 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005515 protein binding	IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func...	UNDECIDED	Summary: protein binding: The PMID:40205054 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:40205054 interaction annotation does not by itself identify a molecular role for PPP4R4. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0005737 cytoplasm	IDA PMID:18715871 PP4R4/KIAA1622 forms a novel stable cytosolic complex with p...	ACCEPT	Summary: cytoplasm: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Reason: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Supporting Evidence: PMID:18715871 we identify a novel, stable cytosolic PP4c interacting partner, KIAA1622, which we have renamed PP4R4. PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.
GO:0005737 cytoplasm	IEA GO_REF:0000044	ACCEPT	Summary: cytoplasm: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Reason: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Supporting Evidence: PMID:18715871 we identify a novel, stable cytosolic PP4c interacting partner, KIAA1622, which we have renamed PP4R4. PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.
GO:0005829 cytosol	IBA GO_REF:0000033	ACCEPT	Summary: cytosol: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Reason: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Supporting Evidence: PMID:18715871 we identify a novel, stable cytosolic PP4c interacting partner, KIAA1622, which we have renamed PP4R4. PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.
GO:0005829 cytosol	IDA GO_REF:0000052	ACCEPT	Summary: cytosol: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Reason: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Supporting Evidence: PMID:18715871 we identify a novel, stable cytosolic PP4c interacting partner, KIAA1622, which we have renamed PP4R4. PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.
GO:0008287 protein serine/threonine phosphatase complex	IBA GO_REF:0000033	ACCEPT	Summary: protein serine/threonine phosphatase complex: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Reason: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Supporting Evidence: PMID:18715871 we identify a novel, stable cytosolic PP4c interacting partner, KIAA1622, which we have renamed PP4R4. PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.
GO:0008287 protein serine/threonine phosphatase complex	IDA PMID:18715871 PP4R4/KIAA1622 forms a novel stable cytosolic complex with p...	ACCEPT	Summary: protein serine/threonine phosphatase complex: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Reason: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Supporting Evidence: PMID:18715871 we identify a novel, stable cytosolic PP4c interacting partner, KIAA1622, which we have renamed PP4R4. PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.
GO:0019888 protein phosphatase regulator activity	IBA GO_REF:0000033	ACCEPT	Summary: protein phosphatase regulator activity: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Reason: Affinity purification identifies PP4R4 as a stable cytosolic PP4c partner. The resulting complex has altered phosphatase activity and is distinct from PP4R1- and PP4R2/3-containing complexes. Supporting Evidence: PMID:18715871 we identify a novel, stable cytosolic PP4c interacting partner, KIAA1622, which we have renamed PP4R4. PMID:18715871 PP4c.PP4R4 complexes exhibit phosphatase activity toward a fluorogenic substrate and gammaH2AX, but this activity is lower than that associated with the PP4c.PP4R2.PP4R3 complex, which itself is less active than the free PP4c catalytic subunit.