PRDX4

id: Q13162
gene_symbol: PRDX4
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for PRDX4'
existing_annotations:
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006979
      label: response to oxidative stress
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008379
      label: thioredoxin peroxidase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042744
      label: hydrogen peroxide catabolic process
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045454
      label: cell redox homeostasis
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005783
      label: endoplasmic reticulum
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0098869
      label: cellular oxidant detoxification
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004601
      label: peroxidase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005783
      label: endoplasmic reticulum
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016209
      label: antioxidant activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016491
      label: oxidoreductase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051920
      label: peroxiredoxin activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140824
      label: thioredoxin-dependent peroxiredoxin activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17644091
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17644091
          supporting_text: 2007 Jul 17. Peroxiredoxin-4 interacts with and 
            regulates the thromboxane A(2) receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21057456
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21057456
          supporting_text: Recycling of peroxiredoxin IV provides a novel 
            pathway for disulphide formation in the endoplasmic reticulum.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21988832
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21988832
          supporting_text: Toward an understanding of the protein interaction 
            network of the human liver.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25959826
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25959826
          supporting_text: 2015 May 7. Quantitative interaction proteomics of 
            neurodegenerative disease proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32814053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32814053
          supporting_text: Interactome Mapping Provides a Network of 
            Neurodegenerative Disease Proteins and Uncovers Widespread Protein 
            Aggregation in Affected Brains.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005783
      label: endoplasmic reticulum
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060090
      label: molecular adaptor activity
    evidence_type: EXP
    original_reference_id: PMID:21916849
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21916849
          supporting_text: Structural insights into the peroxidase activity and 
            inactivation of human peroxiredoxin 4.
  - term:
      id: GO:0140313
      label: molecular sequestering activity
    evidence_type: IDA
    original_reference_id: PMID:21916849
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21916849
          supporting_text: Structural insights into the peroxidase activity and 
            inactivation of human peroxiredoxin 4.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798748
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6800434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034774
      label: secretory granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798748
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1904813
      label: ficolin-1-rich granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6800434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: HDA
    original_reference_id: PMID:21630459
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21630459
          supporting_text: Jun 1. Proteomic characterization of the human sperm 
            nucleus.
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:19199708
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19199708
          supporting_text: Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT).
  - term:
      id: GO:0007252
      label: I-kappaB phosphorylation
    evidence_type: TAS
    original_reference_id: PMID:9388242
    review:
      summary: >-
        OVER-ANNOTATION: PRDX4 is a peroxiredoxin (EC 1.11.1.24) - a thiol-specific
        peroxidase that reduces hydrogen peroxide, NOT a kinase. PMID:9388242 describes
        PRDX4 as having a "Regulatory role... in NF-kappaB activation" and "regulates
        NF-kappaB activity via a modulation of IkappaB-alpha phosphorylation". PRDX4
        affects IkappaB phosphorylation through redox regulation (antioxidant activity),
        not by performing phosphorylation itself. The IKK complex kinases perform
        the
        actual phosphorylation.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:1903719
          label: regulation of I-kappaB phosphorylation
      supported_by:
        - reference_id: PMID:9388242
          supporting_text: Regulatory role for a novel human thioredoxin 
            peroxidase in NF-kappaB activation.
  - term:
      id: GO:0008379
      label: thioredoxin peroxidase activity
    evidence_type: TAS
    original_reference_id: PMID:9388242
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9388242
          supporting_text: Regulatory role for a novel human thioredoxin 
            peroxidase in NF-kappaB activation.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:17644091
    title: Peroxiredoxin-4 interacts with and regulates the thromboxane A(2) 
      receptor.
    findings: []
  - id: PMID:19199708
    title: Proteomic analysis of human parotid gland exosomes by 
      multidimensional protein identification technology (MudPIT).
    findings: []
  - id: PMID:21057456
    title: Recycling of peroxiredoxin IV provides a novel pathway for disulphide
      formation in the endoplasmic reticulum.
    findings: []
  - id: PMID:21630459
    title: Proteomic characterization of the human sperm nucleus.
    findings: []
  - id: PMID:21916849
    title: Structural insights into the peroxidase activity and inactivation of 
      human peroxiredoxin 4.
    findings: []
  - id: PMID:21988832
    title: Toward an understanding of the protein interaction network of the 
      human liver.
    findings: []
  - id: PMID:25959826
    title: Quantitative interaction proteomics of neurodegenerative disease 
      proteins.
    findings: []
  - id: PMID:32814053
    title: Interactome Mapping Provides a Network of Neurodegenerative Disease 
      Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:9388242
    title: Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB
      activation.
    findings: []
  - id: Reactome:R-HSA-6798748
    title: Exocytosis of secretory granule lumen proteins
    findings: []
  - id: Reactome:R-HSA-6800434
    title: Exocytosis of ficolin-rich granule lumen proteins
    findings: []