PSMA1 encodes proteasome subunit alpha type-1, a non-catalytic alpha-ring component of the human 20S core proteasome. It contributes to the architecture and gated entry surface of the 20S core, thereby supporting proteasomal protein catabolism in cytosolic and nuclear proteasome complexes.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: nucleus is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | IBA GO_REF:0000033 | ACCEPT | Summary: proteasome-mediated ubiquitin-dependent protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. Supporting Evidence: file:human/PSMA1/PSMA1-deep-research-falcon.md PSMA1 is thus part of the **execution machinery** for UPS-mediated proteolysis by enabling regulated access to catalytic sites. |
| GO:0019773 proteasome core complex, alpha-subunit complex | IBA GO_REF:0000033 | ACCEPT | Summary: proteasome core complex, alpha-subunit complex is the appropriate core-complex membership annotation for PSMA1. Reason: Structural studies and UniProt summaries place the protein in the 20S proteasome core; this complex-membership annotation is central to the gene product role. Supporting Evidence: file:human/PSMA1/PSMA1-deep-research-falcon.md PSMA1 is one of PSMA1-7 forming the outer Ξ± rings that regulate access to the proteolytic chamber. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: nucleus is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: cytoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005829 cytosol | IEA GO_REF:0000117 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005839 proteasome core complex | IEA GO_REF:0000120 | ACCEPT | Summary: proteasome core complex is the appropriate core-complex membership annotation for PSMA1. Reason: Structural studies and UniProt summaries place the protein in the 20S proteasome core; this complex-membership annotation is central to the gene product role. Supporting Evidence: file:human/PSMA1/PSMA1-deep-research-falcon.md The 20S CP is a barrel made of **four stacked heteroheptameric rings** arranged **Ξ±1β7 Ξ²1β7 Ξ²1β7 Ξ±1β7**; the **two outer Ξ± rings** act as a **gate** that restricts access to the proteolytic chamber. |
| GO:0006511 ubiquitin-dependent protein catabolic process | IEA GO_REF:0000002 | MODIFY | Summary: ubiquitin-dependent protein catabolic process is directionally related to the proteasome role but is less specific than the supported proteasome term. Reason: Replace the broad annotation with proteasome-mediated ubiquitin-dependent protein catabolic process, which better captures the gene product role supported by proteasome literature and existing specific GOA annotations. Proposed replacements: proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO:0019773 proteasome core complex, alpha-subunit complex | IEA GO_REF:0000002 | ACCEPT | Summary: proteasome core complex, alpha-subunit complex is the appropriate core-complex membership annotation for PSMA1. Reason: Structural studies and UniProt summaries place the protein in the 20S proteasome core; this complex-membership annotation is central to the gene product role. |
| GO:0030163 protein catabolic process | IEA GO_REF:0000002 | MODIFY | Summary: protein catabolic process is directionally related to the proteasome role but is less specific than the supported proteasome term. Reason: Replace the broad annotation with proteasomal protein catabolic process, which better captures the gene product role supported by proteasome literature and existing specific GOA annotations. Proposed replacements: proteasomal protein catabolic process |
| GO:0005515 protein binding | IPI PMID:12376572 Mapping and structural dissection of human 20 S proteasome u... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:14733938 Protein-protein interactions among human 20S proteasome subu... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:15225636 The alpha4 and alpha7 subunits and assembly of the 20S prote... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:17948026 The proteasome maturation protein POMP facilitates major ste... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:19060904 An empirical framework for binary interactome mapping. | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:25599644 Crystal structure of the human 20S proteasome in complex wit... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:29568061 An AP-MS- and BioID-compatible MAC-tag enables comprehensive... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:29636472 Structural mechanism for nucleotide-driven remodeling of the... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:31473102 Characterization of Fully Recombinant Human 20S and 20S-PA20... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:34702852 The 20S as a stand-alone proteasome in cells can degrade the... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:35858375 Structural insights into the human PA28-20S proteasome enabl... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0005515 protein binding | IPI PMID:37776851 Analysis of proteome-wide degradation dynamics in ALS SOD1 i... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0000502 proteasome complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0001530 lipopolysaccharide binding | IEA GO_REF:0000107 | REMOVE | Summary: Lipopolysaccharide binding is not supported as a human PSMA1 core function. Reason: This is an automated computational projection and is not supported by the human PSMA1 UniProt functional summary or the proteasome structural literature reviewed here. |
| GO:0002862 negative regulation of inflammatory response to antigenic stimulus | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: negative regulation of inflammatory response to antigenic stimulus is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0140756 structural constituent of proteasome | IDA PMID:27493187 The inhibition mechanism of human 20S proteasomes enables ne... | ACCEPT | Summary: PSMA1 is a non-catalytic alpha-ring subunit whose core molecular role is structural contribution to the 20S proteasome. Reason: Human proteasome structures and reviews support alpha subunits as structural components of the 20S core; PSMA1 should receive structural constituent/complex membership, not catalytic protease activity. Supporting Evidence: file:human/PSMA1/PSMA1-deep-research-falcon.md PSMA1βs primary function is to serve as an essential **structural subunit of the 20S Ξ± ring**, contributing to: file:human/PSMA1/PSMA1-deep-research-falcon.md Importantly, **PSMA1 is not a catalytic peptidase active site**; proteolysis occurs at catalytic **Ξ² subunits**. |
| GO:0000502 proteasome complex | NAS PMID:29636472 Structural mechanism for nucleotide-driven remodeling of the... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0000502 proteasome complex | NAS PMID:33729481 Proteasome in action: substrate degradation by the 26S prote... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0000502 proteasome complex | NAS PMID:37228199 An abundance of free regulatory (19S) proteasome particles r... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0005829 cytosol | NAS PMID:12032076 Properties of the hybrid form of the 26S proteasome containi... | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0008021 synaptic vesicle | NAS PMID:37228199 An abundance of free regulatory (19S) proteasome particles r... | KEEP AS NON CORE | Summary: synaptic vesicle is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0010498 proteasomal protein catabolic process | NAS PMID:33729481 Proteasome in action: substrate degradation by the 26S prote... | ACCEPT | Summary: proteasomal protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | NAS PMID:19489727 Recognition and processing of ubiquitin-protein conjugates b... | ACCEPT | Summary: proteasome-mediated ubiquitin-dependent protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | NAS PMID:33729481 Proteasome in action: substrate degradation by the 26S prote... | ACCEPT | Summary: proteasome-mediated ubiquitin-dependent protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. |
| GO:0061136 regulation of proteasomal protein catabolic process | NAS PMID:12032076 Properties of the hybrid form of the 26S proteasome containi... | MARK AS OVER ANNOTATED | Summary: regulation of proteasomal protein catabolic process is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0000502 proteasome complex | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0000502 proteasome complex | IPI PMID:31283222 Design and Evaluation of Highly Selective Human Immunoprotea... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0000502 proteasome complex | NAS PMID:32134919 Cryo-EM structures of the human PA200 and PA200-20S complex ... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0000502 proteasome complex | IPI PMID:34702852 The 20S as a stand-alone proteasome in cells can degrade the... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0000502 proteasome complex | IPI PMID:35714770 Proteasome activator 28Ξ³ (PA28Ξ³) allosterically activates tr... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0000502 proteasome complex | IPI PMID:35858375 Structural insights into the human PA28-20S proteasome enabl... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0002376 immune system process | NAS PMID:33019542 Adaptation of Proteasomes and Lysosomes to Cellular Environm... | MARK AS OVER ANNOTATED | Summary: immune system process is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0005634 nucleus | NAS PMID:32134919 Cryo-EM structures of the human PA200 and PA200-20S complex ... | ACCEPT | Summary: nucleus is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005634 nucleus | NAS PMID:33019542 Adaptation of Proteasomes and Lysosomes to Cellular Environm... | ACCEPT | Summary: nucleus is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005634 nucleus | NAS PMID:35858375 Structural insights into the human PA28-20S proteasome enabl... | ACCEPT | Summary: nucleus is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005737 cytoplasm | NAS PMID:35858375 Structural insights into the human PA28-20S proteasome enabl... | KEEP AS NON CORE | Summary: cytoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005839 proteasome core complex | IPI PMID:34702852 The 20S as a stand-alone proteasome in cells can degrade the... | ACCEPT | Summary: proteasome core complex is the appropriate core-complex membership annotation for PSMA1. Reason: Structural studies and UniProt summaries place the protein in the 20S proteasome core; this complex-membership annotation is central to the gene product role. |
| GO:0006281 DNA repair | NAS PMID:32134919 Cryo-EM structures of the human PA200 and PA200-20S complex ... | MARK AS OVER ANNOTATED | Summary: DNA repair is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0006915 apoptotic process | NAS PMID:32935661 Role of oncogenic REGΞ³ in cancer. | MARK AS OVER ANNOTATED | Summary: apoptotic process is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0006974 DNA damage response | NAS PMID:32134919 Cryo-EM structures of the human PA200 and PA200-20S complex ... | MARK AS OVER ANNOTATED | Summary: DNA damage response is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0006979 response to oxidative stress | IDA PMID:34702852 The 20S as a stand-alone proteasome in cells can degrade the... | MARK AS OVER ANNOTATED | Summary: response to oxidative stress is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0006979 response to oxidative stress | NAS PMID:35858375 Structural insights into the human PA28-20S proteasome enabl... | MARK AS OVER ANNOTATED | Summary: response to oxidative stress is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0007283 spermatogenesis | NAS PMID:23706739 Acetylation-mediated proteasomal degradation of core histone... | MARK AS OVER ANNOTATED | Summary: spermatogenesis is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0010498 proteasomal protein catabolic process | NAS PMID:23569244 Thymoproteasome subunit-Ξ²5T generates peptide-MHC complexes ... | ACCEPT | Summary: proteasomal protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. |
| GO:0010498 proteasomal protein catabolic process | NAS PMID:23706739 Acetylation-mediated proteasomal degradation of core histone... | ACCEPT | Summary: proteasomal protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. |
| GO:0010498 proteasomal protein catabolic process | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | ACCEPT | Summary: proteasomal protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. |
| GO:0010498 proteasomal protein catabolic process | IDA PMID:34702852 The 20S as a stand-alone proteasome in cells can degrade the... | ACCEPT | Summary: proteasomal protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. Supporting Evidence: file:human/PSMA1/PSMA1-deep-research-falcon.md Identified substrates are enriched for intrinsically disordered RNA- and DNA-binding proteins, especially nuclear and stress-granule proteins. |
| GO:0010499 proteasomal ubiquitin-independent protein catabolic process | NAS PMID:31473102 Characterization of Fully Recombinant Human 20S and 20S-PA20... | ACCEPT | Summary: proteasomal ubiquitin-independent protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Falcon deep research reinforces this, noting that about half of cellular proteasomes exist as free 20S complexes that degrade substrates (especially intrinsically disordered, nuclear, and stress-granule proteins) independently of ubiquitin, and PSMA1 is a constitutive alpha-ring subunit of these free 20S cores. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. Ubiquitin-independent degradation by free 20S is now a systematically characterized pathway in which PSMA1-containing cores participate. Supporting Evidence: file:human/PSMA1/PSMA1-deep-research-falcon.md Pepelnjak et al. (2024) emphasize that **~half of cellular proteasomes** can exist as **free 20S complexes**, enabling ubiquitin-independent turnover of certain substratesβespecially proteins with **intrinsically disordered regions (IDRs)** and enrichment among **nuclear and stress granule proteins**. |
| GO:0030317 flagellated sperm motility | NAS PMID:23706739 Acetylation-mediated proteasomal degradation of core histone... | MARK AS OVER ANNOTATED | Summary: flagellated sperm motility is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0030317 flagellated sperm motility | NAS PMID:27003159 Proteasome activators, PA28Ξ³ and PA200, play indispensable r... | MARK AS OVER ANNOTATED | Summary: flagellated sperm motility is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0032729 positive regulation of type II interferon production | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | MARK AS OVER ANNOTATED | Summary: positive regulation of type II interferon production is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0032743 positive regulation of interleukin-2 production | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | MARK AS OVER ANNOTATED | Summary: positive regulation of interleukin-2 production is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0032760 positive regulation of tumor necrosis factor production | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | MARK AS OVER ANNOTATED | Summary: positive regulation of tumor necrosis factor production is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0034341 response to type II interferon | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | MARK AS OVER ANNOTATED | Summary: response to type II interferon is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0034515 proteasome storage granule | NAS PMID:31380390 Regulation of Proteasome Activity by (Post-)transcriptional ... | KEEP AS NON CORE | Summary: proteasome storage granule is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | IDA PMID:34702852 The 20S as a stand-alone proteasome in cells can degrade the... | ACCEPT | Summary: proteasome-mediated ubiquitin-dependent protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome. Reason: The gene product is a core 20S proteasome subunit, so proteasomal protein catabolism is an appropriate core biological-process context. |
| GO:0043374 CD8-positive, alpha-beta T cell differentiation | NAS PMID:33019542 Adaptation of Proteasomes and Lysosomes to Cellular Environm... | MARK AS OVER ANNOTATED | Summary: CD8-positive, alpha-beta T cell differentiation is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0045061 thymic T cell selection | NAS PMID:30650357 Restricted Expression of the Thymoproteasome Is Required for... | MARK AS OVER ANNOTATED | Summary: thymic T cell selection is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0045063 T-helper 1 cell differentiation | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | MARK AS OVER ANNOTATED | Summary: T-helper 1 cell differentiation is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0045590 negative regulation of regulatory T cell differentiation | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | MARK AS OVER ANNOTATED | Summary: negative regulation of regulatory T cell differentiation is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0051321 meiotic cell cycle | NAS PMID:23706739 Acetylation-mediated proteasomal degradation of core histone... | MARK AS OVER ANNOTATED | Summary: meiotic cell cycle is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0061136 regulation of proteasomal protein catabolic process | IDA PMID:35714770 Proteasome activator 28Ξ³ (PA28Ξ³) allosterically activates tr... | MARK AS OVER ANNOTATED | Summary: regulation of proteasomal protein catabolic process is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0061136 regulation of proteasomal protein catabolic process | NAS PMID:35714770 Proteasome activator 28Ξ³ (PA28Ξ³) allosterically activates tr... | MARK AS OVER ANNOTATED | Summary: regulation of proteasomal protein catabolic process is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0071357 cellular response to type I interferon | NAS PMID:31380390 Regulation of Proteasome Activity by (Post-)transcriptional ... | MARK AS OVER ANNOTATED | Summary: cellular response to type I interferon is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0072539 T-helper 17 cell differentiation | NAS PMID:30104634 The immunoproteasome and thymoproteasome: functions, evoluti... | MARK AS OVER ANNOTATED | Summary: T-helper 17 cell differentiation is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0160165 CD8-positive, alpha-beta T cell homeostasis | NAS PMID:33815406 The Role of Proteasomes in the Thymus. | MARK AS OVER ANNOTATED | Summary: CD8-positive, alpha-beta T cell homeostasis is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:1990111 spermatoproteasome complex | NAS PMID:35377789 Proteasome complexes experience profound structural and func... | KEEP AS NON CORE | Summary: spermatoproteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:2000045 regulation of G1/S transition of mitotic cell cycle | NAS PMID:32935661 Role of oncogenic REGΞ³ in cancer. | MARK AS OVER ANNOTATED | Summary: regulation of G1/S transition of mitotic cell cycle is a pathway- or physiology-level consequence of proteasome activity rather than a specific function of PSMA1. Reason: These annotations are largely projected from whole proteasome complexes or specialized proteasome variants; they should not be interpreted as individual subunit core functions. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0016604 nuclear body | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: nuclear body is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005634 nucleus | EXP PMID:12181345 Clastosome: a subtype of nuclear body enriched in 19S and 20... | ACCEPT | Summary: nucleus is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. Supporting Evidence: file:human/PSMA1/PSMA1-deep-research-falcon.md Proteasomes exist in both the **cytoplasm and nucleus**. file:human/PSMA1/PSMA1-deep-research-falcon.md Under PSMD1 knockdown (reducing intact 26S), the authors observed that ββfreeβ 20S CPs remained nuclear, whereas the 19S RP accumulated in the cytoplasm,β indicating compartment-specific dynamics of PSMA1-containing cores versus 19S components. |
| GO:0005737 cytoplasm | EXP PMID:12181345 Clastosome: a subtype of nuclear body enriched in 19S and 20... | KEEP AS NON CORE | Summary: cytoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1168640 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1234159 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1236970 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1504193 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-174105 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-174202 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-174203 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-174255 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-180573 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-180603 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-209061 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2130282 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-264458 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-353125 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3640874 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-450466 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4608855 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4641256 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4641260 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5362448 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5387392 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5607724 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5607731 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5610754 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5610758 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5610760 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5635868 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5658430 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5665854 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5665871 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668481 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668520 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5687112 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5689539 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-68948 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-69016 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-75825 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8850992 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8852354 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854044 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854071 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8866553 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8866858 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8932355 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8956140 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8956184 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8957265 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9755303 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9755306 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9766223 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-983150 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9907898 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9907912 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9907919 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9907925 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9907928 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9907940 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9907941 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9908052 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9908069 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9908101 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9908178 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9908709 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9908721 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9912636 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9912655 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9912747 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9912751 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9929352 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9929486 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9931314 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9934893 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9954728 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-212917 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-5610751 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-9011324 | ACCEPT | Summary: cytosol is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005634 nucleus | IDA PMID:34711951 AKIRIN2 controls the nuclear import of proteasomes in verteb... | ACCEPT | Summary: nucleus is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0005737 cytoplasm | IDA PMID:34711951 AKIRIN2 controls the nuclear import of proteasomes in verteb... | KEEP AS NON CORE | Summary: cytoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005839 proteasome core complex | IDA PMID:34711951 AKIRIN2 controls the nuclear import of proteasomes in verteb... | ACCEPT | Summary: proteasome core complex is the appropriate core-complex membership annotation for PSMA1. Reason: Structural studies and UniProt summaries place the protein in the 20S proteasome core; this complex-membership annotation is central to the gene product role. |
| GO:0005515 protein binding | IPI PMID:29804830 ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Cl... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0000502 proteasome complex | IDA PMID:17323924 Mass spectrometric characterization of the affinity-purified... | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | KEEP AS NON CORE | Summary: extracellular exosome is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005634 nucleus | HDA PMID:21630459 Proteomic characterization of the human sperm nucleus. | ACCEPT | Summary: nucleus is a core cellular context for the assembled proteasome containing PSMA1. Reason: The reviewed core function occurs in cytosolic and nuclear proteasome pools, supported by proteasome localization and nuclear-import evidence. |
| GO:0070062 extracellular exosome | HDA PMID:19056867 Large-scale proteomics and phosphoproteomics of urinary exos... | KEEP AS NON CORE | Summary: extracellular exosome is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0070062 extracellular exosome | HDA PMID:20458337 MHC class II-associated proteins in B-cell exosomes and pote... | KEEP AS NON CORE | Summary: extracellular exosome is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-174058 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-187574 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-188191 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5635854 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-68825 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-69600 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8939801 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8952408 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9762096 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-NUL-9604648 | KEEP AS NON CORE | Summary: nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function. Reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as context without replacing the core catalytic/structural role. |
| GO:0005839 proteasome core complex | ISS GO_REF:0000024 | ACCEPT | Summary: proteasome core complex is the appropriate core-complex membership annotation for PSMA1. Reason: Structural studies and UniProt summaries place the protein in the 20S proteasome core; this complex-membership annotation is central to the gene product role. |
| GO:0005515 protein binding | IPI PMID:17292860 Conserved signal peptide of Notch3 inhibits interaction with... | MARK AS OVER ANNOTATED | Summary: The interaction evidence may show physical association, but generic protein binding is too low-information for the reviewed function of this proteasome subunit. Reason: For proteasome subunits, the informative annotations are catalytic activity, structural constituent activity, complex membership, and proteasomal protein catabolism; generic protein binding should not be treated as a core function. |
| GO:0019773 proteasome core complex, alpha-subunit complex | ISS GO_REF:0000024 | ACCEPT | Summary: proteasome core complex, alpha-subunit complex is the appropriate core-complex membership annotation for PSMA1. Reason: Structural studies and UniProt summaries place the protein in the 20S proteasome core; this complex-membership annotation is central to the gene product role. |
| GO:0000502 proteasome complex | TAS PMID:8811196 Structure and functions of the 20S and 26S proteasomes. | KEEP AS NON CORE | Summary: proteasome complex is true complex membership but broader or more context-specific than the core 20S subunit identity. Reason: The core review should emphasize the specific 20S core subcomplex membership; broader proteasome or spermatoproteasome membership can be retained as non-core context. |
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Download this section (compressed HTML)Q: Should non-catalytic proteasome alpha subunits use contributes_to for complex-level protease activity, or should GO curation prefer structural constituent of proteasome plus part_of complex annotations?
Suggested experts: Tomko RJ Jr, Hochstrasser M
Experiment: Use purified proteasome complexes or separation-of-function PSMA1 mutants at alpha-ring/regulator interfaces, then measure assembly, gate opening, substrate entry, and beta-subunit peptidase activity separately.
Hypothesis: PSMA1 contributes structurally to alpha-ring gating/regulator docking but does not directly catalyze peptide bond hydrolysis.
Type: structure-guided mutagenesis with proteasome activity and assembly assays
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