PTPN6

id: P29350
gene_symbol: PTPN6
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for PTPN6'
existing_annotations:
  - term:
      id: GO:0001784
      label: phosphotyrosine residue binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030154
      label: cell differentiation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000278
      label: mitotic cell cycle
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004726
      label: non-membrane spanning protein tyrosine phosphatase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004721
      label: phosphoprotein phosphatase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016787
      label: hydrolase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031295
      label: T cell costimulation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060338
      label: regulation of type I interferon-mediated signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902564
      label: negative regulation of neutrophil activation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10206955
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10206955
          supporting_text: The myeloid-specific sialic acid-binding receptor, 
            CD33, associates with the protein-tyrosine phosphatases, SHP-1 and 
            SHP-2.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10556798
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10556798
          supporting_text: The sialoadhesin CD33 is a myeloid-specific 
            inhibitory receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10660620
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10660620
          supporting_text: PILRalpha, a novel immunoreceptor tyrosine-based 
            inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine 
            phosphorylation and is paired with the truncated counterpart 
            PILRbeta.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10764762
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10764762
          supporting_text: Identification and characterization of 
            leukocyte-associated Ig-like receptor-1 as a major anchor protein of
            tyrosine phosphatase SHP-1 in hematopoietic cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11266449
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11266449
          supporting_text: Negative regulation of Ros receptor tyrosine kinase 
            signaling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11489943
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11489943
          supporting_text: >-
            a novel SH2D1A-associated surface molecule contributing to the
            inability of natural killer cells to kill Epstein-Barr
            virus-infected B cells in X-linked lymphoproliferative disease.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:14652006
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14652006
          supporting_text: Characterization of phosphotyrosine binding motifs in
            the cytoplasmic domain of B and T lymphocyte attenuator required for
            association with protein tyrosine phosphatases SHP-1 and SHP-2.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17416557
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17416557
          supporting_text: 'doi: 10.1016/j.jchromb.2007.03.019.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17947393
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17947393
          supporting_text: 'ITIM-dependent endocytosis of CD33-related Siglecs: role
            of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases,
            Shp1 and Shp2.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18086677
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18086677
          supporting_text: 2007 Dec 17. Dynamic regulation of neutrophil 
            survival through tyrosine phosphorylation or dephosphorylation of 
            caspase-8.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18377662
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18377662
          supporting_text: Src homology 2 (SH2) domain containing protein 
            tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and 
            attenuates endothelial DNA synthesis, but not migration*.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18802077
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18802077
          supporting_text: Inhibitory immunoglobulin-like receptors LILRB and 
            PIR-B negatively regulate osteoclast development.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19167335
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19167335
          supporting_text: Large-scale structural analysis of the classical 
            human protein tyrosine phosphatome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20351292
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20351292
          supporting_text: Contribution of SHP-1 protein tyrosine phosphatase to
            osmotic regulation of the transcription factor TonEBP/OREBP.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22624718
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22624718
          supporting_text: Tetraspanin CD37 directly mediates transduction of 
            survival and apoptotic signals.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23001144
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23001144
          supporting_text: Inhibition of TLR signaling by a bacterial protein 
            containing immunoreceptor tyrosine-based inhibitory motifs.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24216507
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24216507
          supporting_text: Induction of myelodysplasia by myeloid-derived 
            suppressor cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24642916
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24642916
          supporting_text: eCollection 2014. Fine specificity and molecular 
            competition in SLAM family receptor signalling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25416956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25416956
          supporting_text: A proteome-scale map of the human interactome 
            network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25535246
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25535246
          supporting_text: A THEMIS:SHP1 complex promotes T-cell survival.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25785436
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25785436
          supporting_text: eCollection 2015. Dissociation of SHP-1 from 
            spinophilin during platelet activation exposes an inhibitory binding
            site for protein phosphatase-1 (PP1).
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:28065597
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28065597
          supporting_text: 2017 Jan 5. A Global Analysis of the Receptor 
            Tyrosine Kinase-Protein Phosphatase Interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31980649
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31980649
          supporting_text: Extensive rewiring of the EGFR network in colorectal 
            cancer cells expressing transforming levels of KRAS(G13D).
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7228577
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7228577
          supporting_text: Cyclophosphamide, vincristine, and the blood testis 
            barrier.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7528537
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7528537
          supporting_text: 'Intramolecular regulation of protein tyrosine phosphatase
            SH-PTP1: a new function for Src homology 2 domains.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7528577
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7528577
          supporting_text: 'Hematopoietic cell phosphatase associates with erythropoietin
            (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification
            of potential binding sites.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8114715
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8114715
          supporting_text: Lck-dependent tyrosyl phosphorylation of the 
            phosphotyrosine phosphatase SH-PTP1 in murine T cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8574854
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8574854
          supporting_text: Recruitment of tyrosine phosphatase HCP by the killer
            cell inhibitor receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8577729
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8577729
          supporting_text: Differential functions of the two Src homology 2 
            domains in protein tyrosine phosphatase SH-PTP1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8627166
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8627166
          supporting_text: CD22 associates with protein tyrosine phosphatase 1C,
            Syk, and phospholipase C-gamma(1) upon B cell activation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8648092
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8648092
          supporting_text: Human and mouse killer-cell inhibitory receptors 
            recruit PTP1C and PTP1D protein tyrosine phosphatases.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8691146
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8691146
          supporting_text: Phosphotyrosines in the killer cell inhibitory 
            receptor motif of NKB1 are required for negative signaling and for 
            association with protein tyrosine phosphatase 1C.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8691154
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8691154
          supporting_text: Tyrosine phosphorylation of a human killer inhibitory
            receptor recruits protein tyrosine phosphatase 1C.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9148918
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9148918
          supporting_text: A novel phosphotyrosine motif with a critical amino 
            acid at position -2 for the SH2 domain-mediated activation of the 
            tyrosine phosphatase SHP-1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9603468
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9603468
          supporting_text: Thymocyte activation induces the association of the 
            proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9774457
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9774457
          supporting_text: Recruitment and activation of SHP-1 protein-tyrosine 
            phosphatase by human platelet endothelial cell adhesion molecule-1 
            (PECAM-1).
  - term:
      id: GO:0001784
      label: phosphotyrosine residue binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005911
      label: cell-cell junction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017124
      label: SH3 domain binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031665
      label: negative regulation of lipopolysaccharide-mediated signaling 
        pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032715
      label: negative regulation of interleukin-6 production
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032720
      label: negative regulation of tumor necrosis factor production
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033007
      label: negative regulation of mast cell activation involved in immune 
        response
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042105
      label: alpha-beta T cell receptor complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042169
      label: SH2 domain binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050839
      label: cell adhesion molecule binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0106015
      label: negative regulation of inflammatory response to wounding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1905867
      label: epididymis development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005730
      label: nucleolus
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: IDA
    original_reference_id: PMID:29925997
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29925997
          supporting_text: Jun 20. The E3 ligases Itch and WWP2 cooperate to 
            limit T(H)2 differentiation by enhancing signaling through the TCR.
  - term:
      id: GO:0019221
      label: cytokine-mediated signaling pathway
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-512988
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031295
      label: T cell costimulation
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-388841
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060338
      label: regulation of type I interferon-mediated signaling pathway
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-912694
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389758
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-914036
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9701507
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-997314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: IMP
    original_reference_id: PMID:19749791
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19749791
          supporting_text: Sep 14. Repression of SHP-1 expression by p53 leads 
            to trkA tyrosine phosphorylation and suppression of breast cancer 
            cell proliferation.
  - term:
      id: GO:0031665
      label: negative regulation of lipopolysaccharide-mediated signaling 
        pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902564
      label: negative regulation of neutrophil activation
    evidence_type: IDA
    original_reference_id: PMID:34234773
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:34234773
          supporting_text: eCollection 2021. The Inhibitory Receptor CLEC12A 
            Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and 
            Cytokine Release.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12051764
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12051764
          supporting_text: SPAP2, an Ig family receptor containing both ITIMs 
            and ITAMs.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:9065461
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9065461
          supporting_text: Interleukin-4 (IL-4) induces phosphatidylinositol 
            3-kinase (p85) dephosphorylation.
  - term:
      id: GO:0042110
      label: T cell activation
    evidence_type: IDA
    original_reference_id: PMID:38354704
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:38354704
          supporting_text: Signaling via a CD27-TRAF2-SHP-1 axis during naive T 
            cell activation promotes memory-associated gene regulatory networks.
  - term:
      id: GO:0160162
      label: CD27 signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:38354704
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:38354704
          supporting_text: Signaling via a CD27-TRAF2-SHP-1 axis during naive T 
            cell activation promotes memory-associated gene regulatory networks.
  - term:
      id: GO:0045824
      label: negative regulation of innate immune response
    evidence_type: IDA
    original_reference_id: PMID:34811497
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:34811497
          supporting_text: Epub 2021 Nov 22. HIV-1 Vif suppresses antiviral 
            immunity by targeting STING.
  - term:
      id: GO:0050859
      label: negative regulation of B cell receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:35941532
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:35941532
          supporting_text: Interfering B cell receptor signaling via SHP-1/p-Lyn
            axis shows therapeutic potential in diffuse large B-cell lymphoma.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:23896411
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23896411
          supporting_text: 2013 Jul 29. Thrombospondin-1 modulates VEGF 
            signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in 
            microvascular endothelial cells.
  - term:
      id: GO:0016525
      label: negative regulation of angiogenesis
    evidence_type: IDA
    original_reference_id: PMID:23896411
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23896411
          supporting_text: 2013 Jul 29. Thrombospondin-1 modulates VEGF 
            signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in 
            microvascular endothelial cells.
  - term:
      id: GO:0106015
      label: negative regulation of inflammatory response to wounding
    evidence_type: IDA
    original_reference_id: PMID:27830702
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27830702
          supporting_text: Hyperglycaemia inhibits REG3A expression to 
            exacerbate TLR3-mediated skin inflammation in diabetes.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16493035
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16493035
          supporting_text: Recombinant Ig-like transcript 3-Fc modulates T cell 
            responses via induction of Th anergy and differentiation of CD8+ T 
            suppressor cells.
  - term:
      id: GO:0140031
      label: phosphorylation-dependent protein binding
    evidence_type: IPI
    original_reference_id: PMID:11162587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11162587
          supporting_text: Molecular cloning and characterization of SPAP1, an 
            inhibitory receptor.
  - term:
      id: GO:0042981
      label: regulation of apoptotic process
    evidence_type: TAS
    original_reference_id: PMID:10506221
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10506221
          supporting_text: Regulation of acidification and apoptosis by SHP-1 
            and Bcl-2.
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: IMP
    original_reference_id: PMID:10206955
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10206955
          supporting_text: The myeloid-specific sialic acid-binding receptor, 
            CD33, associates with the protein-tyrosine phosphatases, SHP-1 and 
            SHP-2.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10887109
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10887109
          supporting_text: Myeloid specific human CD33 is an inhibitory receptor
            with differential ITIM function in recruiting the phosphatases SHP-1
            and SHP-2.
  - term:
      id: GO:0032715
      label: negative regulation of interleukin-6 production
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032720
      label: negative regulation of tumor necrosis factor production
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001784
      label: phosphotyrosine residue binding
    evidence_type: IPI
    original_reference_id: PMID:11986327
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11986327
          supporting_text: 2002 May 1. Cloning and characterization of human 
            Siglec-11.
  - term:
      id: GO:0140031
      label: phosphorylation-dependent protein binding
    evidence_type: IPI
    original_reference_id: PMID:12163025
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12163025
          supporting_text: Cloning of two new splice variants of Siglec-10 and 
            mapping of the interaction between Siglec-10 and SHP-1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19843936
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19843936
          supporting_text: FCRL3, an autoimmune susceptibility gene, has 
            inhibitory potential on B-cell receptor-mediated signaling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20933011
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20933011
          supporting_text: 'Epub 2010 Oct 7. FCRL6 receptor: expression and associated
            proteins.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26755705
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26755705
          supporting_text: Identification of CD112R as a novel checkpoint for 
            human T cells.
  - term:
      id: GO:0004725
      label: protein tyrosine phosphatase activity
    evidence_type: IMP
    original_reference_id: PMID:17562706
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17562706
          supporting_text: 2007 Jun 11. Identification of CLEC12B, an inhibitory
            receptor on myeloid cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17562706
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17562706
          supporting_text: 2007 Jun 11. Identification of CLEC12B, an inhibitory
            receptor on myeloid cells.
  - term:
      id: GO:0032991
      label: protein-containing complex
    evidence_type: IMP
    original_reference_id: PMID:17562706
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17562706
          supporting_text: 2007 Jun 11. Identification of CLEC12B, an inhibitory
            receptor on myeloid cells.
  - term:
      id: GO:0035335
      label: peptidyl-tyrosine dephosphorylation
    evidence_type: IMP
    original_reference_id: PMID:17562706
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17562706
          supporting_text: 2007 Jun 11. Identification of CLEC12B, an inhibitory
            receptor on myeloid cells.
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9008894
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23112346
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23112346
          supporting_text: Mice lacking the ITIM-containing receptor G6b-B 
            exhibit macrothrombocytopenia and aberrant platelet function.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798745
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798749
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035580
      label: specific granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798749
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1904724
      label: tertiary granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798745
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23696226
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23696226
          supporting_text: Jun 18. CEACAM1 on activated NK cells inhibits 
            NKG2D-mediated cytolytic function and signaling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18424730
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18424730
          supporting_text: Carcinoembryonic antigen-related cell adhesion 
            molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10540326
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10540326
          supporting_text: Molecular and functional characterization of IRp60, a
            member of the immunoglobulin superfamily that functions as an 
            inhibitory receptor in human NK cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16254138
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16254138
          supporting_text: Oct 27. The inhibitory receptor IRp60 (CD300a) 
            suppresses the effects of IL-5, GM-CSF, and eotaxin on human 
            peripheral blood eosinophils.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16339535
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16339535
          supporting_text: The inhibitory receptor IRp60 (CD300a) is expressed 
            and functional on human mast cells.
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:19056867
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19056867
          supporting_text: 2008 Dec 3. Large-scale proteomics and 
            phosphoproteomics of urinary exosomes.
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:20458337
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20458337
          supporting_text: 2010 May 11. MHC class II-associated proteins in 
            B-cell exosomes and potential functional implications for exosome 
            biogenesis.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-205306
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-210277
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389758
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389759
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-389941
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5684169
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5690701
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-909738
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-913424
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-914036
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9701507
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9851072
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-997314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11907092
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11907092
          supporting_text: Mutational analysis of immunoreceptor tyrosine-based 
            inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte 
            receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9285411
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9285411
          supporting_text: A novel immunoglobulin superfamily receptor for 
            cellular and viral MHC class I molecules.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9842885
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9842885
          supporting_text: The MHC class I binding proteins LIR-1 and LIR-2 
            inhibit Fc receptor-mediated signaling in monocytes.
  - term:
      id: GO:0018108
      label: peptidyl-tyrosine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:9285411
    review:
      summary: >-
        CRITICAL MISANNOTATION: PTPN6 (SHP-1) is a PHOSPHATASE (EC 3.1.3.48 "protein
        tyrosine phosphatase"), NOT a kinase. Its name literally contains "phosphatase":
        "Tyrosine-protein phosphatase non-receptor type 6". PTPN6 catalyzes the REMOVAL
        of phosphate from tyrosine residues, the opposite of phosphorylation. The
        protein
        is correctly annotated to GO:0035335 "peptidyl-tyrosine dephosphorylation"
        (the reaction it actually catalyzes). Annotating a phosphatase to "peptidyl-tyrosine
        phosphorylation" is fundamentally incorrect.
      action: REMOVE
      supported_by:
        - reference_id: PMID:9285411
          supporting_text: A novel immunoglobulin superfamily receptor for 
            cellular and viral MHC class I molecules.
  - term:
      id: GO:0018108
      label: peptidyl-tyrosine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:18802077
    review:
      summary: >-
        CRITICAL MISANNOTATION: PTPN6 (SHP-1) is a PHOSPHATASE. PMID:18802077 explicitly
        identifies SHP-1 as "Src homology 2 domain-containing tyrosine phosphatase
        1"
        and describes how inhibitory receptors "constitutively recruit SHP-1" to dephosphorylate
        signaling molecules. The paper supports SHP-1 acting as a phosphatase, not
        as
        a kinase. This annotation has the opposite polarity - PTPN6 dephosphorylates,
        not phosphorylates.
      action: REMOVE
      supported_by:
        - reference_id: PMID:18802077
          supporting_text: Inhibitory immunoglobulin-like receptors LILRB and 
            PIR-B negatively regulate osteoclast development.
  - term:
      id: GO:0005001
      label: transmembrane receptor protein tyrosine phosphatase activity
    evidence_type: IDA
    original_reference_id: PMID:11266449
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11266449
          supporting_text: Negative regulation of Ros receptor tyrosine kinase 
            signaling.
  - term:
      id: GO:0006470
      label: protein dephosphorylation
    evidence_type: IDA
    original_reference_id: PMID:11266449
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11266449
          supporting_text: Negative regulation of Ros receptor tyrosine kinase 
            signaling.
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IPI
    original_reference_id: PMID:11266449
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11266449
          supporting_text: Negative regulation of Ros receptor tyrosine kinase 
            signaling.
  - term:
      id: GO:0030154
      label: cell differentiation
    evidence_type: IDA
    original_reference_id: PMID:11266449
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11266449
          supporting_text: Negative regulation of Ros receptor tyrosine kinase 
            signaling.
  - term:
      id: GO:0070372
      label: regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:11266449
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11266449
          supporting_text: Negative regulation of Ros receptor tyrosine kinase 
            signaling.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:10940933
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10940933
          supporting_text: Subcellular localization of intracellular protein 
            tyrosine phosphatases in T cells.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IMP
    original_reference_id: PMID:19749791
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19749791
          supporting_text: Sep 14. Repression of SHP-1 expression by p53 leads 
            to trkA tyrosine phosphorylation and suppression of breast cancer 
            cell proliferation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19838216
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19838216
          supporting_text: Knockdown of protein tyrosine phosphatase SHP-1 
            inhibits G1/S progression in prostate cancer cells through the 
            regulation of components of the cell-cycle machinery.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:19838216
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19838216
          supporting_text: Knockdown of protein tyrosine phosphatase SHP-1 
            inhibits G1/S progression in prostate cancer cells through the 
            regulation of components of the cell-cycle machinery.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:19838216
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19838216
          supporting_text: Knockdown of protein tyrosine phosphatase SHP-1 
            inhibits G1/S progression in prostate cancer cells through the 
            regulation of components of the cell-cycle machinery.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IMP
    original_reference_id: PMID:19838216
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19838216
          supporting_text: Knockdown of protein tyrosine phosphatase SHP-1 
            inhibits G1/S progression in prostate cancer cells through the 
            regulation of components of the cell-cycle machinery.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IMP
    original_reference_id: PMID:19838216
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19838216
          supporting_text: Knockdown of protein tyrosine phosphatase SHP-1 
            inhibits G1/S progression in prostate cancer cells through the 
            regulation of components of the cell-cycle machinery.
  - term:
      id: GO:2000045
      label: regulation of G1/S transition of mitotic cell cycle
    evidence_type: IMP
    original_reference_id: PMID:19838216
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19838216
          supporting_text: Knockdown of protein tyrosine phosphatase SHP-1 
            inhibits G1/S progression in prostate cancer cells through the 
            regulation of components of the cell-cycle machinery.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18604210
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18604210
          supporting_text: An essential function for beta-arrestin 2 in the 
            inhibitory signaling of natural killer cells.
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: TAS
    original_reference_id: PMID:7781604
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7781604
          supporting_text: Tyrosine phosphorylation of an SH2-containing protein
            tyrosine phosphatase is coupled to platelet thrombin receptor via a 
            pertussis toxin-sensitive heterotrimeric G-protein.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: TAS
    original_reference_id: PMID:10506221
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10506221
          supporting_text: Regulation of acidification and apoptosis by SHP-1 
            and Bcl-2.
  - term:
      id: GO:0008285
      label: negative regulation of cell population proliferation
    evidence_type: NAS
    original_reference_id: PMID:10497187
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10497187
          supporting_text: Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its 
            C-terminal structure and catalytic activity.
references:
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10206955
    title: The myeloid-specific sialic acid-binding receptor, CD33, associates 
      with the protein-tyrosine phosphatases, SHP-1 and SHP-2.
    findings: []
  - id: PMID:10497187
    title: Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal 
      structure and catalytic activity.
    findings: []
  - id: PMID:10506221
    title: Regulation of acidification and apoptosis by SHP-1 and Bcl-2.
    findings: []
  - id: PMID:10540326
    title: Molecular and functional characterization of IRp60, a member of the 
      immunoglobulin superfamily that functions as an inhibitory receptor in 
      human NK cells.
    findings: []
  - id: PMID:10556798
    title: The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.
    findings: []
  - id: PMID:10660620
    title: PILRalpha, a novel immunoreceptor tyrosine-based inhibitory 
      motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is
      paired with the truncated counterpart PILRbeta.
    findings: []
  - id: PMID:10764762
    title: Identification and characterization of leukocyte-associated Ig-like 
      receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in 
      hematopoietic cells.
    findings: []
  - id: PMID:10887109
    title: Myeloid specific human CD33 is an inhibitory receptor with 
      differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
    findings: []
  - id: PMID:10940933
    title: Subcellular localization of intracellular protein tyrosine 
      phosphatases in T cells.
    findings: []
  - id: PMID:11162587
    title: Molecular cloning and characterization of SPAP1, an inhibitory 
      receptor.
    findings: []
  - id: PMID:11266449
    title: Negative regulation of Ros receptor tyrosine kinase signaling. An 
      epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
    findings: []
  - id: PMID:11489943
    title: NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface 
      molecule contributing to the inability of natural killer cells to kill 
      Epstein-Barr virus-infected B cells in X-linked lymphoproliferative 
      disease.
    findings: []
  - id: PMID:11907092
    title: Mutational analysis of immunoreceptor tyrosine-based inhibition 
      motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor.
    findings: []
  - id: PMID:11986327
    title: Cloning and characterization of human Siglec-11. A recently evolved 
      signaling molecule that can interact with SHP-1 and SHP-2 and is expressed
      by tissue macrophages, including brain microglia.
    findings: []
  - id: PMID:12051764
    title: SPAP2, an Ig family receptor containing both ITIMs and ITAMs.
    findings: []
  - id: PMID:12163025
    title: 'Cloning of two new splice variants of Siglec-10 and mapping of the interaction
      between Siglec-10 and SHP-1.'
    findings: []
  - id: PMID:14652006
    title: Characterization of phosphotyrosine binding motifs in the cytoplasmic
      domain of B and T lymphocyte attenuator required for association with 
      protein tyrosine phosphatases SHP-1 and SHP-2.
    findings: []
  - id: PMID:16254138
    title: The inhibitory receptor IRp60 (CD300a) suppresses the effects of 
      IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
    findings: []
  - id: PMID:16339535
    title: 'The inhibitory receptor IRp60 (CD300a) is expressed and functional on
      human mast cells.'
    findings: []
  - id: PMID:16493035
    title: Recombinant Ig-like transcript 3-Fc modulates T cell responses via 
      induction of Th anergy and differentiation of CD8+ T suppressor cells.
    findings: []
  - id: PMID:17416557
    title: 'Monitoring phosphatase reactions of multiple phosphorylated substrates
      by reversed-phase HPLC.'
    findings: []
  - id: PMID:17562706
    title: Identification of CLEC12B, an inhibitory receptor on myeloid cells.
    findings: []
  - id: PMID:17947393
    title: 'ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular
      domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2.'
    findings: []
  - id: PMID:18086677
    title: Dynamic regulation of neutrophil survival through tyrosine 
      phosphorylation or dephosphorylation of caspase-8.
    findings: []
  - id: PMID:18377662
    title: Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1
      (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA 
      synthesis, but not migration*.
    findings: []
  - id: PMID:18424730
    title: Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits 
      proximal TCR signaling by targeting ZAP-70.
    findings: []
  - id: PMID:18604210
    title: An essential function for beta-arrestin 2 in the inhibitory signaling
      of natural killer cells.
    findings: []
  - id: PMID:18802077
    title: Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively 
      regulate osteoclast development.
    findings: []
  - id: PMID:19056867
    title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
    findings: []
  - id: PMID:19167335
    title: Large-scale structural analysis of the classical human protein 
      tyrosine phosphatome.
    findings: []
  - id: PMID:19749791
    title: Repression of SHP-1 expression by p53 leads to trkA tyrosine 
      phosphorylation and suppression of breast cancer cell proliferation.
    findings: []
  - id: PMID:19838216
    title: 'Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression
      in prostate cancer cells through the regulation of components of the cell-cycle
      machinery.'
    findings: []
  - id: PMID:19843936
    title: FCRL3, an autoimmune susceptibility gene, has inhibitory potential on
      B-cell receptor-mediated signaling.
    findings: []
  - id: PMID:20351292
    title: Contribution of SHP-1 protein tyrosine phosphatase to osmotic 
      regulation of the transcription factor TonEBP/OREBP.
    findings: []
  - id: PMID:20458337
    title: MHC class II-associated proteins in B-cell exosomes and potential 
      functional implications for exosome biogenesis.
    findings: []
  - id: PMID:20933011
    title: 'FCRL6 receptor: expression and associated proteins.'
    findings: []
  - id: PMID:22624718
    title: Tetraspanin CD37 directly mediates transduction of survival and 
      apoptotic signals.
    findings: []
  - id: PMID:23001144
    title: Inhibition of TLR signaling by a bacterial protein containing 
      immunoreceptor tyrosine-based inhibitory motifs.
    findings: []
  - id: PMID:23112346
    title: 'Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia
      and aberrant platelet function.'
    findings: []
  - id: PMID:23696226
    title: CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic 
      function and signaling.
    findings: []
  - id: PMID:23896411
    title: Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting 
      SHP-1 to VEGFR2 complex in microvascular endothelial cells.
    findings: []
  - id: PMID:24216507
    title: 'Induction of myelodysplasia by myeloid-derived suppressor cells.'
    findings: []
  - id: PMID:24642916
    title: 'Fine specificity and molecular competition in SLAM family receptor signalling.'
    findings: []
  - id: PMID:25416956
    title: A proteome-scale map of the human interactome network.
    findings: []
  - id: PMID:25535246
    title: A THEMIS:SHP1 complex promotes T-cell survival.
    findings: []
  - id: PMID:25785436
    title: Dissociation of SHP-1 from spinophilin during platelet activation 
      exposes an inhibitory binding site for protein phosphatase-1 (PP1).
    findings: []
  - id: PMID:26755705
    title: Identification of CD112R as a novel checkpoint for human T cells.
    findings: []
  - id: PMID:27830702
    title: Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated 
      skin inflammation in diabetes.
    findings: []
  - id: PMID:28065597
    title: A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase
      Interactome.
    findings: []
  - id: PMID:29925997
    title: The E3 ligases Itch and WWP2 cooperate to limit T(H)2 differentiation
      by enhancing signaling through the TCR.
    findings: []
  - id: PMID:31980649
    title: Extensive rewiring of the EGFR network in colorectal cancer cells 
      expressing transforming levels of KRAS(G13D).
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:34234773
    title: The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to 
      Inhibit Neutrophil Activation and Cytokine Release.
    findings: []
  - id: PMID:34811497
    title: HIV-1 Vif suppresses antiviral immunity by targeting STING.
    findings: []
  - id: PMID:35941532
    title: Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows 
      therapeutic potential in diffuse large B-cell lymphoma.
    findings: []
  - id: PMID:38354704
    title: Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation 
      promotes memory-associated gene regulatory networks.
    findings: []
  - id: PMID:7228577
    title: Cyclophosphamide, vincristine, and the blood testis barrier.
    findings: []
  - id: PMID:7528537
    title: 'Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new
      function for Src homology 2 domains.'
    findings: []
  - id: PMID:7528577
    title: 'Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor
      after Epo-induced receptor tyrosine phosphorylation: identification of potential
      binding sites.'
    findings: []
  - id: PMID:7781604
    title: Tyrosine phosphorylation of an SH2-containing protein tyrosine 
      phosphatase is coupled to platelet thrombin receptor via a pertussis 
      toxin-sensitive heterotrimeric G-protein.
    findings: []
  - id: PMID:8114715
    title: Lck-dependent tyrosyl phosphorylation of the phosphotyrosine 
      phosphatase SH-PTP1 in murine T cells.
    findings: []
  - id: PMID:8574854
    title: Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor 
      receptor.
    findings: []
  - id: PMID:8577729
    title: Differential functions of the two Src homology 2 domains in protein 
      tyrosine phosphatase SH-PTP1.
    findings: []
  - id: PMID:8627166
    title: CD22 associates with protein tyrosine phosphatase 1C, Syk, and 
      phospholipase C-gamma(1) upon B cell activation.
    findings: []
  - id: PMID:8648092
    title: Human and mouse killer-cell inhibitory receptors recruit PTP1C and 
      PTP1D protein tyrosine phosphatases.
    findings: []
  - id: PMID:8691146
    title: Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1
      are required for negative signaling and for association with protein 
      tyrosine phosphatase 1C.
    findings: []
  - id: PMID:8691154
    title: 'Tyrosine phosphorylation of a human killer inhibitory receptor recruits
      protein tyrosine phosphatase 1C.'
    findings: []
  - id: PMID:9065461
    title: Interleukin-4 (IL-4) induces phosphatidylinositol 3-kinase (p85) 
      dephosphorylation. Implications for the role of SHP-1 in the IL-4-induced 
      signals in human B cells.
    findings: []
  - id: PMID:9148918
    title: A novel phosphotyrosine motif with a critical amino acid at position 
      -2 for the SH2 domain-mediated activation of the tyrosine phosphatase 
      SHP-1.
    findings: []
  - id: PMID:9285411
    title: 'A novel immunoglobulin superfamily receptor for cellular and viral MHC
      class I molecules.'
    findings: []
  - id: PMID:9603468
    title: Thymocyte activation induces the association of the proto-oncoprotein
      c-cbl and ras GTPase-activating protein with CD5.
    findings: []
  - id: PMID:9774457
    title: Recruitment and activation of SHP-1 protein-tyrosine phosphatase by 
      human platelet endothelial cell adhesion molecule-1 (PECAM-1). 
      Identification of immunoreceptor tyrosine-based inhibitory motif-like 
      binding motifs and substrates.
    findings: []
  - id: PMID:9842885
    title: The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc 
      receptor-mediated signaling in monocytes.
    findings: []
  - id: Reactome:R-HSA-205306
    title: Interaction of SHP1 and KIT
    findings: []
  - id: Reactome:R-HSA-210277
    title: Interaction of PECAM-1 and SHP-1
    findings: []
  - id: Reactome:R-HSA-388841
    title: Regulation of T cell activation by CD28 family
    findings: []
  - id: Reactome:R-HSA-389758
    title: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
    findings: []
  - id: Reactome:R-HSA-389759
    title: Interaction of SHP-1 or SHP-2 with phospho PD-1
    findings: []
  - id: Reactome:R-HSA-389941
    title: SHP-1 and SHP-2 bind pBTLA
    findings: []
  - id: Reactome:R-HSA-512988
    title: Interleukin-3, Interleukin-5 and GM-CSF signaling
    findings: []
  - id: Reactome:R-HSA-5684169
    title: G6B binds PTPN6,PTPN11
    findings: []
  - id: Reactome:R-HSA-5690701
    title: SHP1 binds p-CD22
    findings: []
  - id: Reactome:R-HSA-6798745
    title: Exocytosis of tertiary granule lumen proteins
    findings: []
  - id: Reactome:R-HSA-6798749
    title: Exocytosis of specific granule lumen proteins
    findings: []
  - id: Reactome:R-HSA-9008894
    title: PTPNs gene transcription and translation
    findings: []
  - id: Reactome:R-HSA-909738
    title: SHP1 and SHP2 bind the common beta chain
    findings: []
  - id: Reactome:R-HSA-912694
    title: Regulation of IFNA/IFNB signaling
    findings: []
  - id: Reactome:R-HSA-913424
    title: The SHC1:SHIP1 complex is stabilized by GRB2
    findings: []
  - id: Reactome:R-HSA-914036
    title: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
    findings: []
  - id: Reactome:R-HSA-9701507
    title: PTPN6 dephosphorylates JAK3
    findings: []
  - id: Reactome:R-HSA-9851072
    title: DNMT1-dependent PTPN6 gene silencing
    findings: []
  - id: Reactome:R-HSA-997314
    title: Dephosphorylation of JAK1 by SHP1
    findings: []