RARA

id: P10276
gene_symbol: RARA
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for RARA'
existing_annotations:
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004879
      label: nuclear receptor activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030154
      label: cell differentiation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090575
      label: RNA polymerase II transcription regulator complex
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000978
      label: RNA polymerase II cis-regulatory region sequence-specific DNA 
        binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048384
      label: retinoic acid receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003677
      label: DNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003700
      label: DNA-binding transcription factor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004879
      label: nuclear receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006355
      label: regulation of DNA-templated transcription
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008270
      label: zinc ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043565
      label: sequence-specific DNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048384
      label: retinoic acid receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990837
      label: sequence-specific double-stranded DNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10698945
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10698945
          supporting_text: Structure of the RXR-RAR DNA-binding complex on the 
            retinoic acid response element DR1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16189514
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16189514
          supporting_text: Towards a proteome-scale map of the human 
            protein-protein interaction network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16456540
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16456540
          supporting_text: P38MAPK-dependent phosphorylation and degradation of 
            SRC-3/AIB1 and RARalpha-mediated transcription.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16606617
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16606617
          supporting_text: 2006 Apr 10. Additional sex comb-like 1 (ASXL1), in 
            cooperation with SRC-1, acts as a ligand-dependent coactivator for 
            retinoic acid receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16769902
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16769902
          supporting_text: Phosphorylation by PKA potentiates retinoic acid 
            receptor alpha activity by means of increasing interaction with and 
            phosphorylation by cyclin H/cdk7.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17560333
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17560333
          supporting_text: Role of the polycomb repressive complex 2 in acute 
            promyelocytic leukemia.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17641689
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17641689
          supporting_text: Jul 19. MED25 is distinct from TRAP220/MED1 in 
            cooperating with CBP for retinoid receptor activation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18048326
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18048326
          supporting_text: Identification of retinoic acid as an inhibitor of 
            transcription factor Nrf2 through activation of retinoic acid 
            receptor alpha.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19345331
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19345331
          supporting_text: ZNF423 is critically required for retinoic 
            acid-induced differentiation and is a marker of neuroblastoma 
            outcome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19934264
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19934264
          supporting_text: 'Nov 24. Reciprocal roles of SIRT1 and SKIP in the regulation
            of RAR activity: implication in the retinoic acid-induced neuronal differentiation
            of P19 cells.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20133701
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20133701
          supporting_text: LIM protein Ajuba functions as a nuclear receptor 
            corepressor and negatively regulates retinoic acid signaling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20211142
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20211142
          supporting_text: An atlas of combinatorial transcriptional regulation 
            in mouse and man.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20543827
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20543827
          supporting_text: Jun 13. A unique secondary-structure switch controls 
            constitutive gene repression by retinoic acid receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21478865
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21478865
          supporting_text: Apr 10. Common architecture of nuclear receptor 
            heterodimers on DNA direct repeat elements with different spacings.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21516116
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21516116
          supporting_text: Next-generation sequencing to generate interactome 
            datasets.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21988832
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21988832
          supporting_text: Toward an understanding of the protein interaction 
            network of the human liver.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22056876
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22056876
          supporting_text: A retinoic acid receptor RARα pool present in 
            membrane lipid rafts forms complexes with G protein αQ to activate 
            p38MAPK.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22351778
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22351778
          supporting_text: 2012 Feb 17. Familial focal segmental 
            glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants
            lose ability to activate transcription by nuclear hormone receptors.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23518351
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23518351
          supporting_text: The histone demethylase PHF8 governs retinoic acid 
            response in acute promyelocytic leukemia.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23693014
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23693014
          supporting_text: Activation of Akt pathway by 
            transcription-independent mechanisms of retinoic acid promotes 
            survival and invasion in lung cancer cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24819975
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24819975
          supporting_text: Small ubiquitin-related modifier-1 modification 
            regulates all-trans-retinoic acid-induced differentiation via 
            stabilization of retinoic acid receptor α.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25036637
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25036637
          supporting_text: A quantitative chaperone interaction network reveals 
            the architecture of cellular protein homeostasis pathways.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25241761
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25241761
          supporting_text: Oct 9. Using an in situ proximity ligation assay to 
            systematically profile endogenous protein-protein interactions in a 
            pathway network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25303530
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25303530
          supporting_text: Enhancer activation requires trans-recruitment of a 
            mega transcription factor complex.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25416956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25416956
          supporting_text: A proteome-scale map of the human interactome 
            network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26871637
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26871637
          supporting_text: Widespread Expansion of Protein Interaction 
            Capabilities by Alternative Splicing.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:29892012
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29892012
          supporting_text: Jun 11. An interactome perturbation framework 
            prioritizes damaging missense mutations for developmental disorders.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31515488
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31515488
          supporting_text: Extensive disruption of protein interactions by 
            genetic variants across the allele frequency spectrum in human 
            populations.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:35512704
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:35512704
          supporting_text: 2022 May 4. Systematic discovery of mutation-directed
            neo-protein-protein interactions in cancer.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9653119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9653119
          supporting_text: The TRAP220 component of a thyroid hormone receptor- 
            associated protein (TRAP) coactivator complex interacts directly 
            with nuclear receptors in a ligand-dependent fashion.
  - term:
      id: GO:0000900
      label: mRNA regulatory element binding translation repressor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000976
      label: transcription cis-regulatory region binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000977
      label: RNA polymerase II transcription regulatory region sequence-specific
        DNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001223
      label: transcription coactivator binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001889
      label: liver development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007281
      label: germ cell development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007565
      label: female pregnancy
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008285
      label: negative regulation of cell population proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008584
      label: male gonad development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017148
      label: negative regulation of translation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0021766
      label: hippocampus development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030425
      label: dendrite
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030850
      label: prostate gland development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031641
      label: regulation of myelination
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032355
      label: response to estradiol
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033189
      label: response to vitamin A
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034097
      label: response to cytokine
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042826
      label: histone deacetylase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042981
      label: regulation of apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045471
      label: response to ethanol
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045666
      label: positive regulation of neuron differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048027
      label: mRNA 5'-UTR binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048167
      label: regulation of synaptic plasticity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048471
      label: perinuclear region of cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060010
      label: Sertoli cell fate commitment
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071222
      label: cellular response to lipopolysaccharide
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1901363
      label: heterocyclic compound binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005730
      label: nucleolus
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042789
      label: mRNA transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:1310351
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:1310351
          supporting_text: Retinoid X receptor interacts with nuclear receptors 
            in retinoic acid, thyroid hormone and vitamin D3 signalling.
  - term:
      id: GO:0042789
      label: mRNA transcription by RNA polymerase II
    evidence_type: NAS
    original_reference_id: PMID:9430642
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9430642
          supporting_text: The coactivator TIF2 contains three nuclear 
            receptor-binding motifs and mediates transactivation through CBP 
            binding-dependent and -independent pathways.
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:9430642
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9430642
          supporting_text: The coactivator TIF2 contains three nuclear 
            receptor-binding motifs and mediates transactivation through CBP 
            binding-dependent and -independent pathways.
  - term:
      id: GO:0000785
      label: chromatin
    evidence_type: IDA
    original_reference_id: PMID:2825025
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2825025
          supporting_text: A human retinoic acid receptor which belongs to the 
            family of nuclear receptors.
  - term:
      id: GO:0004879
      label: nuclear receptor activity
    evidence_type: IDA
    original_reference_id: PMID:2825025
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2825025
          supporting_text: A human retinoic acid receptor which belongs to the 
            family of nuclear receptors.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:2825025
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2825025
          supporting_text: A human retinoic acid receptor which belongs to the 
            family of nuclear receptors.
  - term:
      id: GO:0048384
      label: retinoic acid receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:2825025
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2825025
          supporting_text: A human retinoic acid receptor which belongs to the 
            family of nuclear receptors.
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-4341072
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000978
      label: RNA polymerase II cis-regulatory region sequence-specific DNA 
        binding
    evidence_type: IDA
    original_reference_id: PMID:21131358
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21131358
          supporting_text: '2010 Dec 3. Induction of miR-21 by retinoic acid in estrogen
            receptor-positive breast carcinoma cells: biological correlates and molecular
            targets.'
  - term:
      id: GO:0000978
      label: RNA polymerase II cis-regulatory region sequence-specific DNA 
        binding
    evidence_type: IMP
    original_reference_id: PMID:28122350
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28122350
          supporting_text: Transcriptional suppression of microRNA-27a 
            contributes to laryngeal cancer differentiation via GSK-3β-involved 
            Wnt/β-catenin pathway.
  - term:
      id: GO:0001217
      label: DNA-binding transcription repressor activity
    evidence_type: IMP
    original_reference_id: PMID:28122350
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28122350
          supporting_text: Transcriptional suppression of microRNA-27a 
            contributes to laryngeal cancer differentiation via GSK-3β-involved 
            Wnt/β-catenin pathway.
  - term:
      id: GO:0071300
      label: cellular response to retinoic acid
    evidence_type: IMP
    original_reference_id: PMID:28122350
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28122350
          supporting_text: Transcriptional suppression of microRNA-27a 
            contributes to laryngeal cancer differentiation via GSK-3β-involved 
            Wnt/β-catenin pathway.
  - term:
      id: GO:1902894
      label: negative regulation of miRNA transcription
    evidence_type: IMP
    original_reference_id: PMID:28122350
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28122350
          supporting_text: Transcriptional suppression of microRNA-27a 
            contributes to laryngeal cancer differentiation via GSK-3β-involved 
            Wnt/β-catenin pathway.
  - term:
      id: GO:0001223
      label: transcription coactivator binding
    evidence_type: IPI
    original_reference_id: PMID:17641689
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17641689
          supporting_text: Jul 19. MED25 is distinct from TRAP220/MED1 in 
            cooperating with CBP for retinoid receptor activation.
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:21131358
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21131358
          supporting_text: '2010 Dec 3. Induction of miR-21 by retinoic acid in estrogen
            receptor-positive breast carcinoma cells: biological correlates and molecular
            targets.'
  - term:
      id: GO:1990837
      label: sequence-specific double-stranded DNA binding
    evidence_type: IDA
    original_reference_id: PMID:28473536
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28473536
          supporting_text: Impact of cytosine methylation on DNA binding 
            specificities of human transcription factors.
  - term:
      id: GO:0000977
      label: RNA polymerase II transcription regulatory region sequence-specific
        DNA binding
    evidence_type: IDA
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0000978
      label: RNA polymerase II cis-regulatory region sequence-specific DNA 
        binding
    evidence_type: IDA
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0003682
      label: chromatin binding
    evidence_type: IDA
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0032991
      label: protein-containing complex
    evidence_type: IDA
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0032991
      label: protein-containing complex
    evidence_type: IDA
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0048384
      label: retinoic acid receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0000785
      label: chromatin
    evidence_type: IDA
    original_reference_id: PMID:21131358
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21131358
          supporting_text: '2010 Dec 3. Induction of miR-21 by retinoic acid in estrogen
            receptor-positive breast carcinoma cells: biological correlates and molecular
            targets.'
  - term:
      id: GO:0004879
      label: nuclear receptor activity
    evidence_type: IDA
    original_reference_id: PMID:21131358
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21131358
          supporting_text: '2010 Dec 3. Induction of miR-21 by retinoic acid in estrogen
            receptor-positive breast carcinoma cells: biological correlates and molecular
            targets.'
  - term:
      id: GO:0000785
      label: chromatin
    evidence_type: ISA
    original_reference_id: GO_REF:0000113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000981
      label: DNA-binding transcription factor activity, RNA polymerase 
        II-specific
    evidence_type: ISA
    original_reference_id: GO_REF:0000113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051393
      label: alpha-actinin binding
    evidence_type: IPI
    original_reference_id: PMID:22351778
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22351778
          supporting_text: 2012 Feb 17. Familial focal segmental 
            glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants
            lose ability to activate transcription by nuclear hormone receptors.
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5334854
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5634103
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9009817
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-376419
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-382096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9617067
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9860125
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043422
      label: protein kinase B binding
    evidence_type: IPI
    original_reference_id: PMID:16417524
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16417524
          supporting_text: Akt phosphorylates and suppresses the transactivation
            of retinoic acid receptor alpha.
  - term:
      id: GO:0051018
      label: protein kinase A binding
    evidence_type: IDA
    original_reference_id: PMID:20215566
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20215566
          supporting_text: Mar 9. Activity of retinoic acid receptor-alpha is 
            directly regulated at its protein kinase A sites in response to 
            follicle-stimulating hormone signaling.
  - term:
      id: GO:0000785
      label: chromatin
    evidence_type: IDA
    original_reference_id: PMID:17363140
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17363140
          supporting_text: The core component of the mammalian SWI/SNF complex 
            SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid 
            receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17363140
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17363140
          supporting_text: The core component of the mammalian SWI/SNF complex 
            SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid 
            receptor.
  - term:
      id: GO:0019899
      label: enzyme binding
    evidence_type: IPI
    original_reference_id: PMID:12039952
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12039952
          supporting_text: 2002 May 30. Identification of protein arginine 
            methyltransferase 2 as a coactivator for estrogen receptor alpha.
  - term:
      id: GO:0044323
      label: retinoic acid-responsive element binding
    evidence_type: IDA
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0019899
      label: enzyme binding
    evidence_type: IPI
    original_reference_id: PMID:9628876
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9628876
          supporting_text: Two distinct nuclear receptor interaction domains in 
            NSD1, a novel SET protein that exhibits characteristics of both 
            corepressors and coactivators.
  - term:
      id: GO:0003700
      label: DNA-binding transcription factor activity
    evidence_type: IDA
    original_reference_id: PMID:18922886
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18922886
          supporting_text: Retinoic acid-dependent activation of the polycystic 
            kidney disease-1 (PKD1) promoter.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:18845237
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18845237
          supporting_text: Oct 25. Retinoic acid regulates the human methionine 
            sulfoxide reductase A (MSRA) gene via two distinct promoters.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0030853
      label: negative regulation of granulocyte differentiation
    evidence_type: IDA
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0031490
      label: chromatin DNA binding
    evidence_type: IDA
    original_reference_id: PMID:19917671
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19917671
          supporting_text: Loss of CAK phosphorylation of RAR{alpha} mediates 
            transcriptional control of retinoid-induced cancer cell 
            differentiation.
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:18845237
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18845237
          supporting_text: Oct 25. Retinoic acid regulates the human methionine 
            sulfoxide reductase A (MSRA) gene via two distinct promoters.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19850744
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19850744
          supporting_text: Oct 22. Small ubiquitin-like modifier-2 modification 
            of retinoic acid receptor-alpha regulates its subcellular 
            localization and transcriptional activity.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:19850744
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19850744
          supporting_text: Oct 22. Small ubiquitin-like modifier-2 modification 
            of retinoic acid receptor-alpha regulates its subcellular 
            localization and transcriptional activity.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IMP
    original_reference_id: PMID:16456540
    review:
      summary: >-
        MISANNOTATION: RARA is a nuclear hormone receptor (retinoic acid receptor)
        that functions as a ligand-activated transcription factor. PMID:16456540
        describes "P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1"
        - p38MAPK is the kinase that phosphorylates SRC-3 coactivator, NOT RARA.
        RARA provides the context for this phosphorylation but does not perform it.
        UniProt confirms RARA "is phosphorylated by AKT1" and "Phosphorylated by PKA"
        - RARA is a SUBSTRATE of kinases, not a kinase itself. RARA has no kinase
        activity (belongs to NR1 nuclear hormone receptor subfamily).
      action: REMOVE
      supported_by:
        - reference_id: PMID:16456540
          supporting_text: P38MAPK-dependent phosphorylation and degradation of 
            SRC-3/AIB1 and RARalpha-mediated transcription.
  - term:
      id: GO:0043277
      label: apoptotic cell clearance
    evidence_type: IMP
    original_reference_id: PMID:19628791
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19628791
          supporting_text: 2009 Jul 23. Induction of transglutaminase 2 by a 
            liver X receptor/retinoic acid receptor alpha pathway increases the 
            clearance of apoptotic cells by human macrophages.
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:19850744
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19850744
          supporting_text: Oct 22. Small ubiquitin-like modifier-2 modification 
            of retinoic acid receptor-alpha regulates its subcellular 
            localization and transcriptional activity.
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:19850744
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19850744
          supporting_text: Oct 22. Small ubiquitin-like modifier-2 modification 
            of retinoic acid receptor-alpha regulates its subcellular 
            localization and transcriptional activity.
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IMP
    original_reference_id: PMID:19628791
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19628791
          supporting_text: 2009 Jul 23. Induction of transglutaminase 2 by a 
            liver X receptor/retinoic acid receptor alpha pathway increases the 
            clearance of apoptotic cells by human macrophages.
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IDA
    original_reference_id: PMID:19628791
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19628791
          supporting_text: 2009 Jul 23. Induction of transglutaminase 2 by a 
            liver X receptor/retinoic acid receptor alpha pathway increases the 
            clearance of apoptotic cells by human macrophages.
  - term:
      id: GO:0019904
      label: protein domain specific binding
    evidence_type: IPI
    original_reference_id: PMID:20413580
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20413580
          supporting_text: 2010 Apr 22. Human ADA3 regulates RARalpha 
            transcriptional activity through direct contact between LxxLL motifs
            and the receptor coactivator pocket.
  - term:
      id: GO:0003700
      label: DNA-binding transcription factor activity
    evidence_type: IDA
    original_reference_id: PMID:20413580
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20413580
          supporting_text: 2010 Apr 22. Human ADA3 regulates RARalpha 
            transcriptional activity through direct contact between LxxLL motifs
            and the receptor coactivator pocket.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IMP
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0045787
      label: positive regulation of cell cycle
    evidence_type: IMP
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IMP
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0051099
      label: positive regulation of binding
    evidence_type: IMP
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0071391
      label: cellular response to estrogen stimulus
    evidence_type: IDA
    original_reference_id: PMID:20080953
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20080953
          supporting_text: Cooperative interaction between retinoic acid 
            receptor-alpha and estrogen receptor in breast cancer.
  - term:
      id: GO:0001972
      label: retinoic acid binding
    evidence_type: IDA
    original_reference_id: PMID:2825025
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2825025
          supporting_text: A human retinoic acid receptor which belongs to the 
            family of nuclear receptors.
  - term:
      id: GO:0032689
      label: negative regulation of type II interferon production
    evidence_type: IDA
    original_reference_id: PMID:18416830
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18416830
          supporting_text: The Retinoic Acid Receptor-alpha mediates human 
            T-cell activation and Th2 cytokine and chemokine production.
  - term:
      id: GO:0032720
      label: negative regulation of tumor necrosis factor production
    evidence_type: IDA
    original_reference_id: PMID:18416830
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18416830
          supporting_text: The Retinoic Acid Receptor-alpha mediates human 
            T-cell activation and Th2 cytokine and chemokine production.
  - term:
      id: GO:0032736
      label: positive regulation of interleukin-13 production
    evidence_type: IDA
    original_reference_id: PMID:18416830
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18416830
          supporting_text: The Retinoic Acid Receptor-alpha mediates human 
            T-cell activation and Th2 cytokine and chemokine production.
  - term:
      id: GO:0032753
      label: positive regulation of interleukin-4 production
    evidence_type: IDA
    original_reference_id: PMID:18416830
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18416830
          supporting_text: The Retinoic Acid Receptor-alpha mediates human 
            T-cell activation and Th2 cytokine and chemokine production.
  - term:
      id: GO:0032754
      label: positive regulation of interleukin-5 production
    evidence_type: IDA
    original_reference_id: PMID:18416830
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18416830
          supporting_text: The Retinoic Acid Receptor-alpha mediates human 
            T-cell activation and Th2 cytokine and chemokine production.
  - term:
      id: GO:0045630
      label: positive regulation of T-helper 2 cell differentiation
    evidence_type: IDA
    original_reference_id: PMID:18416830
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18416830
          supporting_text: The Retinoic Acid Receptor-alpha mediates human 
            T-cell activation and Th2 cytokine and chemokine production.
  - term:
      id: GO:0032526
      label: response to retinoic acid
    evidence_type: IMP
    original_reference_id: PMID:17538076
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17538076
          supporting_text: 2007 May 30. Regulation of 17-beta hydroxysteroid 
            dehydrogenase type 2 in human placental endothelial cells.
  - term:
      id: GO:0048384
      label: retinoic acid receptor signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:17538076
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17538076
          supporting_text: 2007 May 30. Regulation of 17-beta hydroxysteroid 
            dehydrogenase type 2 in human placental endothelial cells.
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      contact between LxxLL motifs and the receptor coactivator pocket.
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      forms complexes with G protein αQ to activate p38MAPK.
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    title: Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4
      (ACTN4) protein mutants lose ability to activate transcription by nuclear 
      hormone receptors.
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    title: The histone demethylase PHF8 governs retinoic acid response in acute 
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      retinoic acid promotes survival and invasion in lung cancer cells.
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      all-trans-retinoic acid-induced differentiation via stabilization of 
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      endogenous protein-protein interactions in a pathway network.
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    title: RAR:RXR binds SUMO-CRABP2:atRA
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    title: SUMO-CRABP2 dissociates from atRA:RAR:RXR
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