GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q96GF1 RNF185 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000318 IBA GO_REF:0000033 FB:FBgn0030693|FB:FBgn0052581|PANTHER:PTN000267874|UniProtKB:Q96GF1|WB:WBGene00004381 9606 Homo sapiens GO_Central E3 ubiquitin-protein ligase RNF185 20241120 UniProtKB Q96GF1 RNF185 involved_in GO:0036503 ERAD pathway biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000267874|UniProtKB:Q96GF1|UniProtKB:Q99942 9606 Homo sapiens GO_Central E3 ubiquitin-protein ligase RNF185 20240205 UniProtKB Q96GF1 RNF185 enables GO:0044390 ubiquitin-like protein conjugating enzyme binding molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000267874|UniProtKB:Q96GF1 9606 Homo sapiens GO_Central E3 ubiquitin-protein ligase RNF185 20170228 UniProtKB Q96GF1 RNF185 enables GO:0004842 ubiquitin-protein transferase activity molecular_function ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00026878 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 located_in GO:0005737 cytoplasm cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00026971 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 located_in GO:0005741 mitochondrial outer membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0172 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 located_in GO:0005783 endoplasmic reticulum cellular_component ECO:0000256 IEA GO_REF:0000002 InterPro:IPR045103 9606 Homo sapiens InterPro E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0097 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 involved_in GO:0006511 ubiquitin-dependent protein catabolic process biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR045103 9606 Homo sapiens InterPro E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 involved_in GO:0036503 ERAD pathway biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00029018 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 located_in GO:0044322 endoplasmic reticulum quality control compartment cellular_component ECO:0000366 IEA GO_REF:0000108 GO:1904380 9606 Homo sapiens GOC E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 enables GO:0046872 metal ion binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR018957 9606 Homo sapiens InterPro E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000501 IEA GO_REF:0000120 InterPro:IPR045103|EC:2.3.2.27 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 involved_in GO:1904380 endoplasmic reticulum mannose trimming biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00089809 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20260601 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19549727 UniProtKB:P51668 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19549727 UniProtKB:P62837 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19549727 UniProtKB:Q969T4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19549727 UniProtKB:Q96LR5 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19549727 UniProtKB:Q9Y2X8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O75915 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q969T4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q96DZ9 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q99942 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9BSR8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9BWQ6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:28514442 UniProtKB:P55061 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:31515488 UniProtKB:Q969T4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:A6NDP7 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:P51668 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:P55061 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:P61086 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:P62837 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q0D2K0 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q13021 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q5J8X5 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q8N2M4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q8NBI2 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q969T4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q96D05-2 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q96EC8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q96HH6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q96LR5 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9BVK8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9BWQ6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9Y2X8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:P55061 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:Q99942 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase RNF185 20260530 UniProtKB Q96GF1 RNF185 involved_in GO:0055085 transmembrane transport biological_process ECO:0000304 TAS Reactome:R-HSA-382556 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20260316 UniProtKB Q96GF1 RNF185 involved_in GO:0016567 protein ubiquitination biological_process ECO:0007322 IEA GO_REF:0000041 UniPathway:UPA00143 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20260227 UniProtKB Q96GF1 RNF185 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000304 TAS Reactome:R-HSA-8866546 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20260222 UniProtKB Q96GF1 RNF185 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000304 TAS Reactome:R-HSA-8867288 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20260222 UniProtKB Q96GF1 RNF185 located_in GO:0005741 mitochondrial outer membrane cellular_component ECO:0000269 EXP PMID:21931693 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20240703 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000269 EXP PMID:27485036 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20240703 UniProtKB Q96GF1 RNF185 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000269 EXP PMID:21931693 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20240703 UniProtKB Q96GF1 RNF185 involved_in GO:0006511 ubiquitin-dependent protein catabolic process biological_process ECO:0000315 IMP PMID:24019521 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20231121 UniProtKB Q96GF1 RNF185 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000314 IDA PMID:24019521 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20231121 UniProtKB Q96GF1 RNF185 involved_in GO:0045089 positive regulation of innate immune response biological_process ECO:0000314 IDA PMID:28273161 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20230810 UniProtKB Q96GF1 RNF185 involved_in GO:1904380 endoplasmic reticulum mannose trimming biological_process ECO:0000304 TAS Reactome:R-HSA-901032 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20230308 UniProtKB Q96GF1 RNF185 involved_in GO:0044314 protein K27-linked ubiquitination biological_process ECO:0000314 IDA PMID:28273161 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20210907 UniProtKB Q96GF1 RNF185 involved_in GO:0051607 defense response to virus biological_process ECO:0000314 IDA PMID:28273161 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20210907 UniProtKB Q96GF1 RNF185 involved_in GO:0060340 positive regulation of type I interferon-mediated signaling pathway biological_process ECO:0000314 IDA PMID:28273161 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20210907 UniProtKB Q96GF1 RNF185 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000314 IDA PMID:28273161 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20210907 UniProtKB Q96GF1 RNF185 enables GO:0044877 protein-containing complex binding molecular_function ECO:0000353 IPI PMID:24019521 UniProtKB:Q9BUN8 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20190422 UniProtKB Q96GF1 RNF185 located_in GO:0005783 endoplasmic reticulum cellular_component ECO:0000314 IDA PMID:27485036 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20181114 UniProtKB Q96GF1 RNF185 enables GO:0043130 ubiquitin binding molecular_function ECO:0000314 IDA PMID:27485036 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20181114 UniProtKB Q96GF1 RNF185 involved_in GO:0051865 protein autoubiquitination biological_process ECO:0000314 IDA PMID:27485036 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20181114 UniProtKB Q96GF1 RNF185 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000314 IDA PMID:27485036 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20181114 UniProtKB Q96GF1 RNF185 involved_in GO:1904294 positive regulation of ERAD pathway biological_process ECO:0000315 IMP PMID:27485036 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20181114 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21931693 UniProtKB:Q12981 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase RNF185 20180711 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866542 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866546 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866551 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866854 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866856 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866857 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8867288 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9931264 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9931298 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9931313 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase RNF185 20160519 UniProtKB Q96GF1 RNF185 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:24019521 UniProtKB:O94905 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20150521 UniProtKB Q96GF1 RNF185 located_in GO:0005783 endoplasmic reticulum cellular_component ECO:0000314 IDA PMID:24019521 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20150521 UniProtKB Q96GF1 RNF185 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000303 NAS PMID:24019521 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20150521 UniProtKB Q96GF1 RNF185 involved_in GO:0036503 ERAD pathway biological_process ECO:0000316 IGI PMID:24019521 UniProtKB:Q99942 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20150521 UniProtKB Q96GF1 RNF185 enables GO:0044390 ubiquitin-like protein conjugating enzyme binding molecular_function ECO:0000353 IPI PMID:24019521 UniProtKB:Q8N2K1 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20150521 UniProtKB Q96GF1 RNF185 enables GO:0044390 ubiquitin-like protein conjugating enzyme binding molecular_function ECO:0000353 IPI PMID:24019521 UniProtKB:Q9Y385 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20150521 UniProtKB Q96GF1 RNF185 involved_in GO:0051865 protein autoubiquitination biological_process ECO:0000314 IDA PMID:24019521 9606 Homo sapiens ParkinsonsUK-UCL E3 ubiquitin-protein ligase RNF185 20150521