RPS3

id: P23396
gene_symbol: RPS3
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for RPS3'
alternative_products:
- name: '1'
  id: P23396-1
- name: '2'
  id: P23396-2
  sequence_note: VSP_046667
existing_annotations:
- term:
    id: GO:0003735
    label: structural constituent of ribosome
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0022627
    label: cytosolic small ribosomal subunit
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001235
    label: positive regulation of apoptotic signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003677
    label: DNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003735
    label: structural constituent of ribosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005819
    label: spindle
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005840
    label: ribosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006281
    label: DNA repair
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006412
    label: translation
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006417
    label: regulation of translation
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006915
    label: apoptotic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006974
    label: DNA damage response
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0015935
    label: small ribosomal subunit
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016829
    label: lyase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0022626
    label: cytosolic ribosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051301
    label: cell division
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140078
    label: class I DNA-(apurinic or apyrimidinic site) endonuclease activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1990904
    label: ribonucleoprotein complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15161933
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18045535
  review:
    summary: >-
      This annotation captures RPS3's interaction with RELA (p65) of the NF-kappaB complex.
      While 'protein binding' is a very general term, the specific interaction with RELA
      is functionally significant for RPS3's role as a transcription coactivator in NF-kappaB
      signaling. A more informative annotation would specify the binding partner (RELA).
    action: MODIFY
    reason: >-
      The generic 'protein binding' term is too vague. PMID:18045535 specifically demonstrates
      interaction with RELA/p65 subunit of NF-kappaB. A more appropriate annotation would be
      to a more specific binding term that captures the functionally relevant interaction
      with a transcription factor. GO:0140297 (DNA-binding transcription factor binding) or
      GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding)
      would be more informative.
    proposed_replacement_terms:
      - id: GO:0140297
        label: DNA-binding transcription factor binding
      - id: GO:0061629
        label: RNA polymerase II-specific DNA-binding transcription factor binding
    supported_by:
      - reference_id: PMID:18045535
        supporting_text: >-
          We identified ribosomal protein S3 (RPS3), a KH domain protein, as a non-Rel subunit
          of p65 homodimer and p65-p50 heterodimer DNA-binding complexes that synergistically
          enhances DNA binding.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18274552
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19656744
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20618440
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21145461
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21146485
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21399639
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22113938
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24457201
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24725412
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25609649
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26526615
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:30021884
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31046837
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32296183
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32814053
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35271311
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:39251607
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:40205054
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003906
    label: DNA-(apurinic or apyrimidinic site) endonuclease activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0022627
    label: cytosolic small ribosomal subunit
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045202
    label: synapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001228
    label: DNA-binding transcription activator activity, RNA polymerase II-specific
  evidence_type: IMP
  original_reference_id: PMID:18045535
  review:
    summary: >-
      This annotation is an over-annotation. PMID:18045535 demonstrates that RPS3 acts as a
      non-Rel subunit of NF-kappaB complexes that synergistically enhances DNA binding of
      p65 homodimer and p65-p50 heterodimer complexes. RPS3 contains a KH domain (an RNA-binding
      domain, not a DNA-binding transcription factor domain) and interacts with the NF-kappaB
      complex via protein-protein interactions with RELA/p65. The study shows RPS3 forms part
      of the NF-kappaB complex bound to regulatory DNA sites, but RPS3 itself does not directly
      bind DNA with sequence specificity. This is transcription coactivator activity, not
      DNA-binding transcription factor activity. The term GO:0001228 requires intrinsic
      sequence-specific DNA binding, which RPS3 lacks.
    action: MODIFY
    reason: >-
      The annotation to GO:0001228 (DNA-binding transcription activator activity, RNA polymerase
      II-specific) is incorrect because this term requires the protein to directly bind DNA in
      a sequence-specific manner to modulate transcription. RPS3 does not possess a canonical
      DNA-binding domain for transcriptional regulation - its KH domain is an RNA-binding motif.
      Per PMID:18045535, RPS3 functions as "a non-Rel subunit of p65 homodimer and p65-p50
      heterodimer DNA-binding complexes that synergistically enhances DNA binding." RPS3 acts
      through protein-protein interactions with the NF-kappaB transcription factors, enhancing
      their activity. This is the definition of transcription coactivator activity (GO:0003713),
      not DNA-binding transcription factor activity. The appropriate annotation should be to
      GO:0003713 (transcription coactivator activity) or potentially GO:0061629 (RNA polymerase
      II-specific DNA-binding transcription factor binding) to reflect that RPS3 binds to and
      modulates the activity of DNA-binding transcription factors without itself being a dbTF.
    proposed_replacement_terms:
      - id: GO:0003713
        label: transcription coactivator activity
      - id: GO:0061629
        label: RNA polymerase II-specific DNA-binding transcription factor binding
    additional_reference_ids:
      - PMID:18045535
    supported_by:
      - reference_id: PMID:18045535
        supporting_text: >-
          We identified ribosomal protein S3 (RPS3), a KH domain protein, as a non-Rel subunit
          of p65 homodimer and p65-p50 heterodimer DNA-binding complexes that synergistically
          enhances DNA binding.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0002181
    label: cytoplasmic translation
  evidence_type: NAS
  original_reference_id: PMID:25901680
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: NAS
  original_reference_id: PMID:25901680
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0002181
    label: cytoplasmic translation
  evidence_type: NAS
  original_reference_id: PMID:1712897
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0002181
    label: cytoplasmic translation
  evidence_type: IC
  original_reference_id: PMID:8706699
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0002183
    label: cytoplasmic translational initiation
  evidence_type: NAS
  original_reference_id: PMID:15883184
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000144
    label: positive regulation of DNA-templated transcription initiation
  evidence_type: IMP
  original_reference_id: PMID:18045535
  review:
    summary: >-
      This annotation reflects RPS3's role in enhancing NF-kappaB-mediated transcription as
      demonstrated in PMID:18045535. The study showed that RPS3 knockdown impaired NF-kappaB-mediated
      transcription of selected p65 target genes, and lymphocyte-activating stimuli caused nuclear
      translocation of RPS3 to form part of NF-kappaB bound to specific regulatory sites in chromatin.
      While this is a biological process annotation that could be retained, it should be noted that
      RPS3's effect on transcription is indirect - through its role as a coactivator of NF-kappaB
      rather than as a direct transcription factor.
    action: ACCEPT
    reason: >-
      The biological process annotation to positive regulation of DNA-templated transcription
      initiation is appropriate because RPS3 does positively regulate transcription through its
      role in the NF-kappaB complex, even though this regulation is through protein-protein
      interactions rather than direct DNA binding. PMID:18045535 demonstrates that RPS3 is
      "an essential but previously unknown subunit of NF-kappaB involved in the regulation of
      key genes in rapid cellular activation responses."
    supported_by:
      - reference_id: PMID:18045535
        supporting_text: >-
          RPS3 knockdown impaired NF-kappaB-mediated transcription of selected p65 target genes
          but not nuclear shuttling or global protein translation. Rather, lymphocyte-activating
          stimuli caused nuclear translocation of RPS3, parallel to p65, to form part of NF-kappaB
          bound to specific regulatory sites in chromatin.
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: EXP
  original_reference_id: PMID:21170055
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: IDA
  original_reference_id: PMID:21170055
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0022626
    label: cytosolic ribosome
  evidence_type: IDA
  original_reference_id: PMID:23636399
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003684
    label: damaged DNA binding
  evidence_type: IDA
  original_reference_id: PMID:15518571
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006284
    label: base-excision repair
  evidence_type: IDA
  original_reference_id: PMID:15518571
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19059439
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006281
    label: DNA repair
  evidence_type: IMP
  original_reference_id: PMID:19059439
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007059
    label: chromosome segregation
  evidence_type: IMP
  original_reference_id: PMID:23131551
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010628
    label: positive regulation of gene expression
  evidence_type: IMP
  original_reference_id: PMID:20605787
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005743
    label: mitochondrial inner membrane
  evidence_type: IDA
  original_reference_id: PMID:23911537
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005759
    label: mitochondrial matrix
  evidence_type: IDA
  original_reference_id: PMID:23911537
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22510408
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20041225
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140297
    label: DNA-binding transcription factor binding
  evidence_type: IPI
  original_reference_id: PMID:20605787
  review:
    summary: >-
      Well-supported annotation. PMID:20605787 demonstrates that RPS3 binds to the E2F1
      transcription factor and acts synergistically with E2F1 to up-regulate proapoptotic
      proteins Dp5/Hrk and Bim. This interaction is regulated by Akt-mediated phosphorylation
      of RPS3, which perturbs its interaction with E2F1. This annotation is appropriate and
      supports the role of RPS3 as a transcriptional coregulator that binds transcription
      factors rather than DNA directly.
    action: ACCEPT
    reason: >-
      The annotation to DNA-binding transcription factor binding is correct based on the
      evidence in PMID:20605787 showing RPS3 physically interacts with E2F1, a DNA-binding
      transcription factor. This is consistent with RPS3's role as a transcriptional
      coregulator that modulates transcription through protein-protein interactions with
      transcription factors (both E2F1 and NF-kappaB/RELA).
    supported_by:
      - reference_id: PMID:20605787
        supporting_text: >-
          RPS3 induced neuronal apoptosis, up-regulating proapoptotic proteins Dp5/Hrk and Bim
          by binding to E2F1 and acting synergistically with it. Akt-dependent phosphorylation
          of RPS3 inhibited its proapoptotic function and perturbed its interaction with E2F1.
- term:
    id: GO:0002181
    label: cytoplasmic translation
  evidence_type: IC
  original_reference_id: PMID:23636399
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003735
    label: structural constituent of ribosome
  evidence_type: IDA
  original_reference_id: PMID:23636399
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030544
    label: Hsp70 protein binding
  evidence_type: IDA
  original_reference_id: PMID:23911537
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034614
    label: cellular response to reactive oxygen species
  evidence_type: IDA
  original_reference_id: PMID:23911537
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: IPI
  original_reference_id: PMID:18973764
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28065601
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28132843
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:17560175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IMP
  original_reference_id: PMID:21399639
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: HDA
  original_reference_id: PMID:21423176
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071159
    label: NF-kappaB complex
  evidence_type: IDA
  original_reference_id: PMID:18045535
  review:
    summary: >-
      Well-supported annotation. PMID:18045535 used tandem affinity purification and mass
      spectrometry to identify RPS3 as a component of the NF-kappaB complex. The study clearly
      shows that RPS3 is "a non-Rel subunit of p65 homodimer and p65-p50 heterodimer DNA-binding
      complexes." RPS3 interacts with RELA (p65) and forms part of the NF-kappaB transcription
      factor complex bound to chromatin in response to activating stimuli.
    action: ACCEPT
    reason: >-
      The proteomic approach in PMID:18045535 directly demonstrates RPS3 is a component of
      NF-kappaB complexes. This was validated by co-IP experiments and functional studies showing
      RPS3 is essential for NF-kappaB function in gene regulation.
    supported_by:
      - reference_id: PMID:18045535
        supporting_text: >-
          We identified ribosomal protein S3 (RPS3), a KH domain protein, as a non-Rel subunit
          of p65 homodimer and p65-p50 heterodimer DNA-binding complexes that synergistically
          enhances DNA binding.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:18045535
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1905053
    label: positive regulation of base-excision repair
  evidence_type: IDA
  original_reference_id: PMID:18973764
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24965446
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0017148
    label: negative regulation of translation
  evidence_type: IDA
  original_reference_id: PMID:20217897
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061481
    label: response to TNF agonist
  evidence_type: IDA
  original_reference_id: PMID:20041225
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:20041225
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1901224
    label: positive regulation of non-canonical NF-kappaB signal transduction
  evidence_type: IDA
  original_reference_id: PMID:20041225
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23911537
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045739
    label: positive regulation of DNA repair
  evidence_type: IDA
  original_reference_id: PMID:23911537
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051879
    label: Hsp90 protein binding
  evidence_type: IDA
  original_reference_id: PMID:23911537
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070301
    label: cellular response to hydrogen peroxide
  evidence_type: IDA
  original_reference_id: PMID:23911537
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:22510408
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008017
    label: microtubule binding
  evidence_type: IDA
  original_reference_id: PMID:23131551
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0015631
    label: tubulin binding
  evidence_type: IDA
  original_reference_id: PMID:23131551
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031116
    label: positive regulation of microtubule polymerization
  evidence_type: IMP
  original_reference_id: PMID:23131551
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051225
    label: spindle assembly
  evidence_type: IMP
  original_reference_id: PMID:23131551
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0072686
    label: mitotic spindle
  evidence_type: IDA
  original_reference_id: PMID:23131551
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902231
    label: positive regulation of intrinsic apoptotic signaling pathway in response
      to DNA damage
  evidence_type: IMP
  original_reference_id: PMID:22510408
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: IDA
  original_reference_id: PMID:20217897
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004520
    label: DNA endonuclease activity
  evidence_type: IDA
  original_reference_id: PMID:20605787
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IMP
  original_reference_id: PMID:21871177
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:20217897
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IMP
  original_reference_id: PMID:21871177
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005840
    label: ribosome
  evidence_type: IDA
  original_reference_id: PMID:20217897
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019900
    label: kinase binding
  evidence_type: IPI
  original_reference_id: PMID:20605787
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019901
    label: protein kinase binding
  evidence_type: IPI
  original_reference_id: PMID:21871177
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042981
    label: regulation of apoptotic process
  evidence_type: IMP
  original_reference_id: PMID:20605787
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044390
    label: ubiquitin-like protein conjugating enzyme binding
  evidence_type: IPI
  original_reference_id: PMID:21968017
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6791223
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031397
    label: negative regulation of protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:19656744
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032358
    label: oxidized pyrimidine DNA binding
  evidence_type: IDA
  original_reference_id: PMID:19656744
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003906
    label: DNA-(apurinic or apyrimidinic site) endonuclease activity
  evidence_type: IDA
  original_reference_id: PMID:19059439
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:19059439
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:19059439
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005840
    label: ribosome
  evidence_type: IDA
  original_reference_id: PMID:19059439
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003677
    label: DNA binding
  evidence_type: IDA
  original_reference_id: PMID:18610840
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003684
    label: damaged DNA binding
  evidence_type: IDA
  original_reference_id: PMID:18610840
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003906
    label: DNA-(apurinic or apyrimidinic site) endonuclease activity
  evidence_type: IDA
  original_reference_id: PMID:18610840
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:19460357
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: IDA
  original_reference_id: PMID:19460357
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005840
    label: ribosome
  evidence_type: IDA
  original_reference_id: PMID:19460357
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019104
    label: DNA N-glycosylase activity
  evidence_type: IDA
  original_reference_id: PMID:18610840
  negated: true
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: IPI
  original_reference_id: PMID:19460357
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070181
    label: small ribosomal subunit rRNA binding
  evidence_type: IDA
  original_reference_id: PMID:18610840
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003906
    label: DNA-(apurinic or apyrimidinic site) endonuclease activity
  evidence_type: IDA
  original_reference_id: PMID:15707971
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004520
    label: DNA endonuclease activity
  evidence_type: IDA
  original_reference_id: PMID:15707971
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019104
    label: DNA N-glycosylase activity
  evidence_type: TAS
  original_reference_id: PMID:15707971
  negated: true
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097100
    label: supercoiled DNA binding
  evidence_type: IDA
  original_reference_id: PMID:15707971
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003684
    label: damaged DNA binding
  evidence_type: IDA
  original_reference_id: PMID:14706345
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032357
    label: oxidized purine DNA binding
  evidence_type: IDA
  original_reference_id: PMID:14706345
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003906
    label: DNA-(apurinic or apyrimidinic site) endonuclease activity
  evidence_type: IDA
  original_reference_id: PMID:7775413
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016020
    label: membrane
  evidence_type: HDA
  original_reference_id: PMID:19946888
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24423872
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001235
    label: positive regulation of apoptotic signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:14988002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: HDA
  original_reference_id: PMID:22658674
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: HDA
  original_reference_id: PMID:22681889
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003684
    label: damaged DNA binding
  evidence_type: IDA
  original_reference_id: PMID:17560175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:16814409
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:17560175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: IPI
  original_reference_id: PMID:15518571
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: HDA
  original_reference_id: PMID:20458337
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-156808
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-156823
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-157849
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1799332
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1799335
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-192704
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-192841
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6791223
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-72619
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-72621
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-72671
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-72672
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-72673
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-72676
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-72691
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-72697
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-927789
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-927813
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-927832
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-927836
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-927889
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9729232
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9729849
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9948291
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9948300
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9948301
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9948317
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9954730
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9954919
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9955731
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051018
    label: protein kinase A binding
  evidence_type: IPI
  original_reference_id: PMID:16814409
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22244329
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1990904
    label: ribonucleoprotein complex
  evidence_type: IDA
  original_reference_id: PMID:17289661
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0022627
    label: cytosolic small ribosomal subunit
  evidence_type: IDA
  original_reference_id: PMID:8706699
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003729
    label: mRNA binding
  evidence_type: IDA
  original_reference_id: PMID:18464793
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003735
    label: structural constituent of ribosome
  evidence_type: NAS
  original_reference_id: PMID:1712897
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:14988002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:14988002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:16814409
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019901
    label: protein kinase binding
  evidence_type: IPI
  original_reference_id: PMID:15950189
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032587
    label: ruffle membrane
  evidence_type: IDA
  original_reference_id: PMID:16814409
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051536
    label: iron-sulfur cluster binding
  evidence_type: NAS
  original_reference_id: PMID:11911468
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003684
    label: damaged DNA binding
  evidence_type: IDA
  original_reference_id: PMID:16737853
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003906
    label: DNA-(apurinic or apyrimidinic site) endonuclease activity
  evidence_type: IDA
  original_reference_id: PMID:16737853
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:18045535
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006974
    label: DNA damage response
  evidence_type: IEP
  original_reference_id: PMID:17560175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045738
    label: negative regulation of DNA repair
  evidence_type: IMP
  original_reference_id: PMID:17049931
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003735
    label: structural constituent of ribosome
  evidence_type: HDA
  original_reference_id: PMID:15883184
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0022627
    label: cytosolic small ribosomal subunit
  evidence_type: HDA
  original_reference_id: PMID:15883184
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
    vocabulary mapping, accompanied by conservative changes to GO terms applied by
    UniProt
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to
    orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000108
  title: Automatic assignment of GO terms using logical inference, based on on inter-ontology
    links
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:11911468
  title: Electron paramagnetic resonance study reveals a putative iron-sulfur cluster
    in human rpS3 protein.
  findings: []
- id: PMID:14706345
  title: Characterization of human ribosomal protein S3 binding to 7,8-dihydro-8-oxoguanine
    and abasic sites by surface plasmon resonance.
  findings: []
- id: PMID:14988002
  title: RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis.
  findings: []
- id: PMID:15161933
  title: Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding
    proteins.
  findings: []
- id: PMID:15518571
  title: Human ribosomal protein S3 interacts with DNA base excision repair proteins
    hAPE/Ref-1 and hOGG1.
  findings: []
- id: PMID:15707971
  title: Characterization of a wide range base-damage-endonuclease activity of mammalian
    rpS3.
  findings: []
- id: PMID:15883184
  title: 'Mass spectrometric analysis of the human 40S ribosomal subunit: native and
    HCV IRES-bound complexes.'
  findings: []
- id: PMID:15950189
  title: Erk phosphorylates threonine 42 residue of ribosomal protein S3.
  findings: []
- id: PMID:16737853
  title: The high binding affinity of human ribosomal protein S3 to 7,8-dihydro-8-oxoguanine
    is abrogated by a single amino acid change.
  findings: []
- id: PMID:16814409
  title: Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3
    in conjunction with Nm23-H1 and ERK.
  findings: []
- id: PMID:17049931
  title: Knockdown of ribosomal protein S3 protects human cells from genotoxic stress.
  findings: []
- id: PMID:1712897
  title: 'Ribosomal protein genes are overexpressed in colorectal cancer: isolation
    of a cDNA clone encoding the human S3 ribosomal protein.'
  findings: []
- id: PMID:17289661
  title: Molecular composition of IMP1 ribonucleoprotein granules.
  findings: []
- id: PMID:17560175
  title: Translocation of human ribosomal protein S3 to sites of DNA damage is dependant
    on ERK-mediated phosphorylation following genotoxic stress.
  findings: []
- id: PMID:18045535
  title: 'Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates
    selective gene regulation.'
  findings: []
- id: PMID:18274552
  title: Ribosomal proteins are targets for the NEDD8 pathway.
  findings: []
- id: PMID:18464793
  title: Ribosomal position and contacts of mRNA in eukaryotic translation initiation
    complexes.
  findings: []
- id: PMID:18610840
  title: '[Interactions of human ribosomal protein S3 with undamaged and damaged DNA].'
  findings: []
- id: PMID:18973764
  title: Human ribosomal protein S3 (hRpS3) interacts with uracil-DNA glycosylase
    (hUNG) and stimulates its glycosylase activity.
  findings: []
- id: PMID:19059439
  title: PKCdelta-dependent functional switch of rpS3 between translation and DNA
    repair.
  findings: []
- id: PMID:19460357
  title: Arginine methylation of ribosomal protein S3 affects ribosome assembly.
  findings: []
- id: PMID:19656744
  title: 'Ribosomal protein S3: A multi-functional protein that interacts with both
    p53 and MDM2 through its KH domain.'
  findings: []
- id: PMID:19946888
  title: Defining the membrane proteome of NK cells.
  findings: []
- id: PMID:20041225
  title: Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function.
  findings: []
- id: PMID:20217897
  title: RpS3 translation is repressed by interaction with its own mRNA.
  findings: []
- id: PMID:20458337
  title: MHC class II-associated proteins in B-cell exosomes and potential functional
    implications for exosome biogenesis.
  findings: []
- id: PMID:20605787
  title: Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator
    between neuronal apoptosis and DNA repair.
  findings: []
- id: PMID:20618440
  title: Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced
    apoptosis.
  findings: []
- id: PMID:21145461
  title: Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative
    proteomics.
  findings: []
- id: PMID:21146485
  title: Identification of cyclophilin-40-interacting proteins reveals potential cellular
    function of cyclophilin-40.
  findings: []
- id: PMID:21170055
  title: Characterization of the proteome, diseases and evolution of the human postsynaptic
    density.
  findings: []
- id: PMID:21399639
  title: IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function
    during infection with Escherichia coli strain O157:H7.
  findings: []
- id: PMID:21423176
  title: Analysis of the myosin-II-responsive focal adhesion proteome reveals a role
    for β-Pix in negative regulation of focal adhesion maturation.
  findings: []
- id: PMID:21871177
  title: Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase.
  findings: []
- id: PMID:21968017
  title: Ribosomal protein S3 is stabilized by sumoylation.
  findings: []
- id: PMID:22113938
  title: A bead-based approach for large-scale identification of in vitro kinase substrates.
  findings: []
- id: PMID:22244329
  title: Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic
    actions.
  findings: []
- id: PMID:22510408
  title: Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase
    dependent JNK activation.
  findings: []
- id: PMID:22658674
  title: Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
  findings: []
- id: PMID:22681889
  title: The mRNA-bound proteome and its global occupancy profile on protein-coding
    transcripts.
  findings: []
- id: PMID:23131551
  title: Ribosomal protein S3 localizes on the mitotic spindle and functions as a
    microtubule associated protein in mitosis.
  findings: []
- id: PMID:23636399
  title: Structures of the human and Drosophila 80S ribosome.
  findings: []
- id: PMID:23911537
  title: Cytoplasmic ribosomal protein S3 (rpS3) plays a pivotal role in mitochondrial
    DNA damage surveillance.
  findings: []
- id: PMID:24423872
  title: AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.
  findings: []
- id: PMID:24457201
  title: Ribosomal protein S3 interacts with the NF-κB inhibitor IκBα.
  findings: []
- id: PMID:24725412
  title: Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in
    Parkinson's disease.
  findings: []
- id: PMID:24965446
  title: Host factors that interact with the pestivirus N-terminal protease, Npro,
    are components of the ribonucleoprotein complex.
  findings: []
- id: PMID:25609649
  title: Proteomic analyses reveal distinct chromatin-associated and soluble transcription
    factor complexes.
  findings: []
- id: PMID:25901680
  title: Structure of the human 80S ribosome.
  findings: []
- id: PMID:26526615
  title: Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription
    by interfering with the p65/RPS3 interaction.
  findings: []
- id: PMID:28065601
  title: Initiation of Quality Control during Poly(A) Translation Requires Site-Specific
    Ribosome Ubiquitination.
  findings: []
- id: PMID:28132843
  title: ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function
    by Mediating Regulatory 40S Ribosomal Ubiquitylation.
  findings: []
- id: PMID:30021884
  title: Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry
    in Intact Cell Nuclei.
  findings: []
- id: PMID:31046837
  title: Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation
    of SERCA activity to control ER stress in astrocytes.
  findings: []
- id: PMID:32296183
  title: A reference map of the human binary protein interactome.
  findings: []
- id: PMID:32814053
  title: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins
    and Uncovers Widespread Protein Aggregation in Affected Brains.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human
    interactome.
  findings: []
- id: PMID:35271311
  title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
  findings: []
- id: PMID:39251607
  title: Systematic identification of post-transcriptional regulatory modules.
  findings: []
- id: PMID:40205054
  title: Multimodal cell maps as a foundation for structural and functional genomics.
  findings: []
- id: PMID:7775413
  title: Implication of mammalian ribosomal protein S3 in the processing of DNA damage.
  findings: []
- id: PMID:8706699
  title: Characterization of the human small-ribosomal-subunit proteins by N-terminal
    and internal sequencing, and mass spectrometry.
  findings: []
- id: Reactome:R-HSA-156808
  title: Formation of translation initiation complexes yielding circularized Ceruloplasmin
    mRNA in a  'closed-loop' conformation
  findings: []
- id: Reactome:R-HSA-156823
  title: Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
  findings: []
- id: Reactome:R-HSA-157849
  title: Formation of translation initiation complexes containing mRNA that does not
    circularize
  findings: []
- id: Reactome:R-HSA-1799332
  title: Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle
    (SRP)
  findings: []
- id: Reactome:R-HSA-1799335
  title: Synthesis of nascent polypeptide containing signal sequence
  findings: []
- id: Reactome:R-HSA-192704
  title: Synthesis of PB1-F2
  findings: []
- id: Reactome:R-HSA-192841
  title: Viral Protein Synthesis
  findings: []
- id: Reactome:R-HSA-6791223
  title: 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation
    from the nucleus to the cytosol
  findings: []
- id: Reactome:R-HSA-72619
  title: eIF2:GTP is hydrolyzed, eIFs are released
  findings: []
- id: Reactome:R-HSA-72621
  title: Ribosomal scanning
  findings: []
- id: Reactome:R-HSA-72671
  title: eIF5B:GTP is hydrolyzed and released
  findings: []
- id: Reactome:R-HSA-72672
  title: The 60S subunit joins the translation initiation complex
  findings: []
- id: Reactome:R-HSA-72673
  title: Release of 40S and 60S subunits from the 80S ribosome
  findings: []
- id: Reactome:R-HSA-72676
  title: eIF3 and eIF1A bind to the 40S subunit
  findings: []
- id: Reactome:R-HSA-72691
  title: Formation of the 43S pre-initiation complex
  findings: []
- id: Reactome:R-HSA-72697
  title: Start codon recognition
  findings: []
- id: Reactome:R-HSA-927789
  title: Formation of UPF1:eRF3 complex on mRNA with a premature termination codon
    and no Exon Junction Complex
  findings: []
- id: Reactome:R-HSA-927813
  title: p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
  findings: []
- id: Reactome:R-HSA-927832
  title: UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex
  findings: []
- id: Reactome:R-HSA-927836
  title: SMG6 hydrolyzes mRNA with premature termination codon
  findings: []
- id: Reactome:R-HSA-927889
  title: SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)
  findings: []
- id: Reactome:R-HSA-9729232
  title: SARS-CoV-1 nsp1 binds to 40S ribosomal subunit
  findings: []
- id: Reactome:R-HSA-9729849
  title: SARS-CoV-2 nsp1 binds to 40S ribosomal complex
  findings: []
- id: Reactome:R-HSA-9948291
  title: RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent
    peptide
  findings: []
- id: Reactome:R-HSA-9948300
  title: RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit
    and 60S subunit:peptidyl-tRNA with nascent peptide
  findings: []
- id: Reactome:R-HSA-9948301
  title: ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal
    subunit
  findings: []
- id: Reactome:R-HSA-9948317
  title: ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome
  findings: []
- id: Reactome:R-HSA-9954730
  title: PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent
    peptide
  findings: []
- id: Reactome:R-HSA-9954919
  title: ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA
    with nascent peptide and HBS1L-1:GDP is released
  findings: []
- id: Reactome:R-HSA-9955731
  title: ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide
    dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA
    with nascent peptide
  findings: []