RPTOR (Raptor) is the defining substrate-presenting subunit of mTOR complex 1 (mTORC1). It is a non-catalytic molecular adaptor with two roles within the complex: it mediates recruitment of mTORC1 to the lysosomal surface by binding the Rag GTPases, and it confers substrate specificity by binding TOS-motif-containing substrates (e.g. EIF4EBP1/4E-BP1 and RPS6KB1/S6K1) and directing them to the active site of the MTOR kinase. Through mTORC1 it couples nutrient, growth-factor and energy signals to the control of cell growth, protein synthesis, autophagy and metabolism.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001558 regulation of cell growth | IMP PMID:20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surfac... | KEEP AS NON CORE | Summary: Downstream growth regulation; non-core. Reason: Regulation of cell growth is a downstream output of mTORC1 signalling; true but peripheral to RPTOR's core adaptor MF. Non-core. |
| GO:0001938 positive regulation of endothelial cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Distal proliferation output; non-core. Reason: Positive regulation of endothelial cell proliferation (IEA) is a distal, tissue-level consequence of mTORC1 activity; non-core. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:18372248 Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) ... | ACCEPT | Summary: contributes_to the mTORC1 kinase activity (subunit); keep. Reason: RPTOR is non-catalytic but is annotated with the contributes_to qualifier to the mTORC1 serine/threonine kinase activity, the correct way to credit a complex subunit for the complex's catalytic activity. Keep. |
| GO:0005515 protein binding | IPI PMID:12150925 mTOR interacts with raptor to form a nutrient-sensitive comp... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | MODIFY | Summary: Interactor is RPS6KB1/S6K1, a protein kinase; recast as protein kinase binding. Reason: The interaction partner is RPS6KB1 (S6K1, UniProtKB:P23443), a protein kinase that RPTOR binds via its TOS motif as an mTORC1 substrate. A binary interaction evidences binding, so the supported refinement is protein kinase binding; the bridging enzyme-substrate adaptor activity itself is already asserted by IDA (GO:0140767). Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | REMOVE | Summary: Bare interactome binding to the TOS-motif substrate EIF4EBP1/4E-BP1 (UniProtKB:Q13541); removed per policy. Reason: The partner is EIF4EBP1/4E-BP1 (UniProtKB:Q13541), a TOS-motif mTORC1 substrate. This is a binary protein-binding (IPI) hit; it evidences binding, not the enzyme-substrate adaptor (bridging) activity, which is already asserted by IDA (GO:0140767). A binding term for this partner would be uninformative, so the bare protein-binding row is removed under the protein-binding policy. |
| GO:0005515 protein binding | IPI PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:12408816 Two TOR complexes, only one of which is rapamycin sensitive,... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:12408816 Two TOR complexes, only one of which is rapamycin sensitive,... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:17386266 PRAS40 is an insulin-regulated inhibitor of the mTORC1 prote... | REMOVE | Summary: Bare interactome binding to the TOS-motif substrate AKT1S1/PRAS40 (UniProtKB:Q96B36); removed per policy. Reason: The partner is AKT1S1/PRAS40 (UniProtKB:Q96B36), a TOS-motif mTORC1 substrate. This is a binary protein-binding (IPI) hit; it evidences binding, not the enzyme-substrate adaptor (bridging) activity, which is already asserted by IDA (GO:0140767). A binding term for this partner would be uninformative, so the bare protein-binding row is removed under the protein-binding policy. |
| GO:0005515 protein binding | IPI PMID:17461779 Identification of Protor as a novel Rictor-binding component... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:17565979 P-Rex1 links mammalian target of rapamycin signaling to Rac ... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:17565979 P-Rex1 links mammalian target of rapamycin signaling to Rac ... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:18337751 cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle... | REMOVE | Summary: Bare interactome binding to the TOS-motif substrate EIF4EBP1/4E-BP1 (UniProtKB:Q13541); removed per policy. Reason: The partner is EIF4EBP1/4E-BP1 (UniProtKB:Q13541), a TOS-motif mTORC1 substrate. This is a binary protein-binding (IPI) hit; it evidences binding, not the enzyme-substrate adaptor (bridging) activity, which is already asserted by IDA (GO:0140767). A binding term for this partner would be uninformative, so the bare protein-binding row is removed under the protein-binding policy. |
| GO:0005515 protein binding | IPI PMID:18955708 Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:19446321 DEPTOR is an mTOR inhibitor frequently overexpressed in mult... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:19446321 DEPTOR is an mTOR inhibitor frequently overexpressed in mult... | REMOVE | Summary: Bare interactome binding to the TOS-motif substrate AKT1S1/PRAS40 (UniProtKB:Q96B36); removed per policy. Reason: The partner is AKT1S1/PRAS40 (UniProtKB:Q96B36), a TOS-motif mTORC1 substrate. This is a binary protein-binding (IPI) hit; it evidences binding, not the enzyme-substrate adaptor (bridging) activity, which is already asserted by IDA (GO:0140767). A binding term for this partner would be uninformative, so the bare protein-binding row is removed under the protein-binding policy. |
| GO:0005515 protein binding | IPI PMID:19619545 Ribavirin enhances interferon signaling via stimulation of m... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:19875983 The target of rapamycin complex 2 controls dendritic tiling ... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:20347422 Postnatal deamidation of 4E-BP2 in brain enhances its associ... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:20543138 mTOR associates with TFIIIC, is found at tRNA and 5S rRNA ge... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:21045808 mTORC2 can associate with ribosomes to promote cotranslation... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:21339740 Selective activation of Akt1 by mammalian target of rapamyci... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:21471201 Cancer cell survival following DNA damage-mediated premature... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:21614075 Probing cellular protein complexes using single-molecule pul... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:22424946 Leucyl-tRNA synthetase is an intracellular leucine sensor fo... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:22424946 Leucyl-tRNA synthetase is an intracellular leucine sensor fo... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:23027611 5-HT(6) receptor recruitment of mTOR as a mechanism for pert... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:23263282 SCFFbxo9 and CK2 direct the cellular response to growth fact... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:23953116 Inhibition of mTORC1 by astrin and stress granules prevents ... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:23953116 Inhibition of mTORC1 by astrin and stress granules prevents ... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:23953116 Inhibition of mTORC1 by astrin and stress granules prevents ... | REMOVE | Summary: Bare interactome binding to the TOS-motif substrate AKT1S1/PRAS40 (UniProtKB:Q96B36); removed per policy. Reason: The partner is AKT1S1/PRAS40 (UniProtKB:Q96B36), a TOS-motif mTORC1 substrate. This is a binary protein-binding (IPI) hit; it evidences binding, not the enzyme-substrate adaptor (bridging) activity, which is already asserted by IDA (GO:0140767). A binding term for this partner would be uninformative, so the bare protein-binding row is removed under the protein-binding policy. |
| GO:0005515 protein binding | IPI PMID:23953116 Inhibition of mTORC1 by astrin and stress granules prevents ... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:24036451 PIH1D1 interacts with mTOR complex 1 and enhances ribosome R... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:24036451 PIH1D1 interacts with mTOR complex 1 and enhances ribosome R... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:24036451 PIH1D1 interacts with mTOR complex 1 and enhances ribosome R... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:24036451 PIH1D1 interacts with mTOR complex 1 and enhances ribosome R... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:24375676 mTORC2 phosphorylates protein kinase CΞΆ to regulate its stab... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:25446900 Rab1A is an mTORC1 activator and a colorectal oncogene. | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:25446900 Rab1A is an mTORC1 activator and a colorectal oncogene. | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:25657994 The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:25686248 Huntingtin functions as a scaffold for selective macroautoph... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:25940091 La-related Protein 1 (LARP1) Represses Terminal Oligopyrimid... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:26348909 GSK3-mediated raptor phosphorylation supports amino-acid-dep... | MODIFY | Summary: Interactor is RPS6KB1/S6K1, a protein kinase; recast as protein kinase binding. Reason: The interaction partner is RPS6KB1 (S6K1, UniProtKB:P23443), a protein kinase that RPTOR binds via its TOS motif as an mTORC1 substrate. A binary interaction evidences binding, so the supported refinement is protein kinase binding; the bridging enzyme-substrate adaptor activity itself is already asserted by IDA (GO:0140767). Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:26348909 GSK3-mediated raptor phosphorylation supports amino-acid-dep... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:26678875 Architecture of human mTOR complex 1. | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:26787466 The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and supp... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:27043084 HSF1 critically attunes proteotoxic stress sensing by mTORC1... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:27043084 HSF1 critically attunes proteotoxic stress sensing by mTORC1... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:29236692 Mechanisms of mTORC1 activation by RHEB and inhibition by PR... | MODIFY | Summary: Interactor is RPS6KB1/S6K1, a protein kinase; recast as protein kinase binding. Reason: The interaction partner is RPS6KB1 (S6K1, UniProtKB:P23443), a protein kinase that RPTOR binds via its TOS motif as an mTORC1 substrate. A binary interaction evidences binding, so the supported refinement is protein kinase binding; the bridging enzyme-substrate adaptor activity itself is already asserted by IDA (GO:0140767). Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:29236692 Mechanisms of mTORC1 activation by RHEB and inhibition by PR... | REMOVE | Summary: Bare interactome binding to the TOS-motif substrate EIF4EBP1/4E-BP1 (UniProtKB:Q13541); removed per policy. Reason: The partner is EIF4EBP1/4E-BP1 (UniProtKB:Q13541), a TOS-motif mTORC1 substrate. This is a binary protein-binding (IPI) hit; it evidences binding, not the enzyme-substrate adaptor (bridging) activity, which is already asserted by IDA (GO:0140767). A binding term for this partner would be uninformative, so the bare protein-binding row is removed under the protein-binding policy. |
| GO:0005515 protein binding | IPI PMID:29236692 Mechanisms of mTORC1 activation by RHEB and inhibition by PR... | REMOVE | Summary: Bare interactome binding to the TOS-motif substrate AKT1S1/PRAS40 (UniProtKB:Q96B36); removed per policy. Reason: The partner is AKT1S1/PRAS40 (UniProtKB:Q96B36), a TOS-motif mTORC1 substrate. This is a binary protein-binding (IPI) hit; it evidences binding, not the enzyme-substrate adaptor (bridging) activity, which is already asserted by IDA (GO:0140767). A binding term for this partner would be uninformative, so the bare protein-binding row is removed under the protein-binding policy. |
| GO:0005515 protein binding | IPI PMID:30232230 The PTH/PTHrP-SIK3 pathway affects skeletogenesis through al... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | MODIFY | Summary: Partner is the MTOR kinase; recast as protein kinase binding. Reason: Interaction partner is the MTOR kinase (UniProtKB:P42345 / mouse ortholog); binding the catalytic subunit of mTORC1 is informatively protein kinase binding, not bare protein binding. This contact is the enzyme side of RPTOR's enzyme-substrate adaptor role. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Bare interactome binding to the TOS-motif substrate AKT1S1/PRAS40 (UniProtKB:Q96B36); removed per policy. Reason: The partner is AKT1S1/PRAS40 (UniProtKB:Q96B36), a TOS-motif mTORC1 substrate. This is a binary protein-binding (IPI) hit; it evidences binding, not the enzyme-substrate adaptor (bridging) activity, which is already asserted by IDA (GO:0140767). A binding term for this partner would be uninformative, so the bare protein-binding row is removed under the protein-binding policy. |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005515 protein binding | IPI PMID:35561222 SNAT7 regulates mTORC1 via macropinocytosis. | REMOVE | Summary: Uninformative interactome protein-binding row; removed per policy. Reason: Bare protein binding (GO:0005515) from a high-throughput/interactome study; uninformative about RPTOR's molecular function and removed under the protein-binding policy. The functionally meaningful contacts (MTOR, TOS-motif substrates, Rag GTPases, MLST8/complex) are captured by specific terms elsewhere in this review. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5082405 | KEEP AS NON CORE | Summary: Minor nucleoplasm location; non-core. Reason: Nucleoplasm (Reactome TAS) is a minor/condition-specific location; non-core relative to the cytosolic and lysosomal pools. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | MODIFY | Summary: Refine cytoplasm to the supported cytosol term. Reason: Cytoplasm is correct but less specific than the cytosol (GO:0005829) that RPTOR carries by direct assay (20 rows); refine to the specific supported location. Propagation Review Root cause: TERM SCOPING PROBLEM Proposed replacements: cytosol |
| GO:0005737 cytoplasm | IDA PMID:20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surfac... | MODIFY | Summary: Refine cytoplasm to the supported cytosol term. Reason: Cytoplasm is correct but less specific than the cytosol (GO:0005829) that RPTOR carries by direct assay (20 rows); refine to the specific supported location. Proposed replacements: cytosol |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | MODIFY | Summary: Refine cytoplasm to the supported cytosol term. Reason: Cytoplasm is correct but less specific than the cytosol (GO:0005829) that RPTOR carries by direct assay (20 rows); refine to the specific supported location. Proposed replacements: cytosol |
| GO:0005764 lysosome | IDA GO_REF:0000052 | ACCEPT | Summary: Lysosome; site of mTORC1 activation. Reason: Lysosome localisation reflects Rag-GTPase-mediated recruitment of mTORC1 to the lysosome, where it is activated; core location. |
| GO:0005764 lysosome | IDA PMID:20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surfac... | ACCEPT | Summary: Lysosome; site of mTORC1 activation. Reason: Lysosome localisation reflects Rag-GTPase-mediated recruitment of mTORC1 to the lysosome, where it is activated; core location. |
| GO:0005764 lysosome | IMP PMID:22424946 Leucyl-tRNA synthetase is an intracellular leucine sensor fo... | ACCEPT | Summary: Lysosome; site of mTORC1 activation. Reason: Lysosome localisation reflects Rag-GTPase-mediated recruitment of mTORC1 to the lysosome, where it is activated; core location. |
| GO:0005765 lysosomal membrane | EXP PMID:31601708 Structural basis for the docking of mTORC1 on the lysosomal ... | ACCEPT | Summary: Lysosomal membrane; core. Reason: Lysosomal membrane is where RPTOR docks mTORC1 via the Rag GTPases; core functional location. |
| GO:0005765 lysosomal membrane | HDA PMID:17897319 Integral and associated lysosomal membrane proteins. | ACCEPT | Summary: Lysosomal membrane; core. Reason: Lysosomal membrane is where RPTOR docks mTORC1 via the Rag GTPases; core functional location. |
| GO:0005765 lysosomal membrane | IDA PMID:31601764 Architecture of human Rag GTPase heterodimers and their comp... | ACCEPT | Summary: Lysosomal membrane; core. Reason: Lysosomal membrane is where RPTOR docks mTORC1 via the Rag GTPases; core functional location. |
| GO:0005765 lysosomal membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Lysosomal membrane; core. Reason: Lysosomal membrane is where RPTOR docks mTORC1 via the Rag GTPases; core functional location. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-165680 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-165692 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-165718 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-377186 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-380979 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-447074 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5653968 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672010 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672017 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672817 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672828 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672843 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5673768 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5675790 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8944454 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9640195 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9645608 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9646468 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9947739 | ACCEPT | Summary: Cytosol; core location. Reason: Cytosol is the principal localisation of mTORC1 components; core location. |
| GO:0006974 DNA damage response | NAS PMID:17041623 Stress and mTORture signaling. | KEEP AS NON CORE | Summary: Distal DNA-damage process; non-core. Reason: DNA damage response (NAS) is a distal process linked to mTORC1; non-core. |
| GO:0008361 regulation of cell size | IMP PMID:12150925 mTOR interacts with raptor to form a nutrient-sensitive comp... | KEEP AS NON CORE | Summary: Cell-size regulation output; non-core. Reason: Regulation of cell size is a classic mTORC1 output; true but downstream of the adaptor MF. Non-core. |
| GO:0009267 cellular response to starvation | IBA GO_REF:0000033 | ACCEPT | Summary: Nutrient/starvation sensing; core. Reason: Cellular response to starvation is central to mTORC1's nutrient-sensing role, in which RPTOR participates as the adaptor. Core nutrient-sensing process. |
| GO:0009410 response to xenobiotic stimulus | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS xenobiotic response; over-annotated. Reason: Response to xenobiotic stimulus (ISS, GO_REF:0000024) is a distal, automatically-propagated process not characteristic of RPTOR; over-annotation. |
| GO:0010494 cytoplasmic stress granule | IDA PMID:25940091 La-related Protein 1 (LARP1) Represses Terminal Oligopyrimid... | ACCEPT | Summary: Stress granule localisation (IDA). Reason: RPTOR/mTORC1 localises to cytoplasmic stress granules under stress (IDA); accurate conditional localisation. |
| GO:0010506 regulation of autophagy | IBA GO_REF:0000033 | ACCEPT | Summary: Regulation of autophagy; core. Reason: Regulation of autophagy is a core mTORC1 output executed through RPTOR-dependent substrate control (e.g. ULK1). Core. |
| GO:0010507 negative regulation of autophagy | IDA PMID:32561715 Leucine regulates autophagy via acetylation of the mTORC1 co... | ACCEPT | Summary: Negative regulation of autophagy; core. Reason: mTORC1 negatively regulates autophagy; RPTOR participates as the substrate-presenting adaptor. Core. |
| GO:0010507 negative regulation of autophagy | NAS PMID:28283069 mTOR Signaling in Growth, Metabolism, and Disease. | ACCEPT | Summary: Negative regulation of autophagy; core. Reason: mTORC1 negatively regulates autophagy; RPTOR participates as the substrate-presenting adaptor. Core. |
| GO:0010646 regulation of cell communication | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Generic signalling-regulation term; non-core. Reason: Regulation of cell communication (IEA) is a generic high-level process; non-core. |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | ACCEPT | Summary: Protein kinase binding (MTOR); core. Reason: Protein kinase binding reflects the direct RPTOR-MTOR interaction; consistent with the MTOR partner rows recast to this term. Core contact. |
| GO:0019901 protein kinase binding | IPI PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoi... | ACCEPT | Summary: Protein kinase binding (MTOR), IPI; core. Reason: Direct binding to the MTOR kinase (IPI); core contact underpinning complex assembly. |
| GO:0019901 protein kinase binding | IPI PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoi... | ACCEPT | Summary: Protein kinase binding (MTOR), IPI; core. Reason: Direct binding to the MTOR kinase (IPI); core contact underpinning complex assembly. |
| GO:0023051 regulation of signaling | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Generic signalling-regulation; non-core. Reason: Regulation of signaling (IEA) is a generic high-level term; non-core. |
| GO:0030291 protein serine/threonine kinase inhibitor activity | IDA PMID:12718876 GbetaL, a positive regulator of the rapamycin-sensitive path... | KEEP AS NON CORE | Summary: Conditional kinase-inhibitor activity; non-core. Reason: Protein serine/threonine kinase inhibitor activity (IDA, PMID:12718876) reflects RPTOR's conditional negative regulation of mTOR under nutrient-poor conditions; a documented secondary MF, retained as non-core relative to the substrate-presenting adaptor role. |
| GO:0030295 protein kinase activator activity | IDA PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | KEEP AS NON CORE | Summary: Kinase-activator framing of the adaptor role; non-core. Reason: Protein kinase activator activity (IDA) is the positive-regulation framing of RPTOR's substrate-presentation role; retained as non-core because enzyme-substrate adaptor activity is the precise core MF. |
| GO:0030307 positive regulation of cell growth | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Growth-promotion output; non-core. Reason: Positive regulation of cell growth is the canonical mTORC1 output; downstream of the adaptor MF. Non-core. |
| GO:0030307 positive regulation of cell growth | IMP PMID:18426977 eIF4GI links nutrient sensing by mTOR to cell proliferation ... | KEEP AS NON CORE | Summary: Growth-promotion output; non-core. Reason: Positive regulation of cell growth is the canonical mTORC1 output; downstream of the adaptor MF. Non-core. |
| GO:0030307 positive regulation of cell growth | NAS PMID:25906254 mLST8 Promotes mTOR-Mediated Tumor Progression. | KEEP AS NON CORE | Summary: Growth-promotion output; non-core. Reason: Positive regulation of cell growth is the canonical mTORC1 output; downstream of the adaptor MF. Non-core. |
| GO:0030425 dendrite | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Dendrite (IEA); non-core. Reason: Dendrite localisation (IEA) is a neuron-specific annotation; plausible for neuronal mTORC1 but non-core and electronically inferred. |
| GO:0030674 protein-macromolecule adaptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: General adaptor activity; core. Reason: General protein-macromolecule adaptor activity; the parent of RPTOR's two specific adaptor roles (recruitment and substrate presentation). Core. Supporting Evidence: PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. |
| GO:0030674 protein-macromolecule adaptor activity | IDA PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | ACCEPT | Summary: Adaptor activity (IDA); core. Reason: Direct evidence that RPTOR acts as the adaptor mediating mTOR action on its substrates. Core. Supporting Evidence: PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. |
| GO:0030674 protein-macromolecule adaptor activity | IDA PMID:37541260 O-GlcNAcylation of Raptor transduces glucose signals to mTOR... | ACCEPT | Summary: Adaptor activity (recruitment); core. Reason: RPTOR mediates recruitment of mTORC1 to the lysosome via the Rag GTPases (PMID:37541260); general adaptor MF. Core. Supporting Evidence: PMID:37541260 facilitates the interactions between Raptor and Rag GTPases and promotes the translocation of mTOR to the lysosomal surface |
| GO:0031267 small GTPase binding | IDA PMID:26588989 NLK phosphorylates Raptor to mediate stress-induced mTORC1 i... | ACCEPT | Summary: Rag small-GTPase binding; core. Reason: RPTOR binds the Rag small GTPases to recruit mTORC1 to the lysosomal surface; the molecular basis of the recruitment-adaptor role. Core. Supporting Evidence: PMID:26588989 NLK phosphorylates Raptor on S863 to disrupt its interaction with the Rag GTPase, which is important for mTORC1 lysosomal recruitment. |
| GO:0031267 small GTPase binding | IDA PMID:37541260 O-GlcNAcylation of Raptor transduces glucose signals to mTOR... | ACCEPT | Summary: Rag small-GTPase binding; core. Reason: RPTOR binds the Rag small GTPases to recruit mTORC1 to the lysosomal surface; the molecular basis of the recruitment-adaptor role. Core. |
| GO:0031669 cellular response to nutrient levels | IDA PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | ACCEPT | Summary: Nutrient-level response; core. Reason: Cellular response to nutrient levels is the defining mTORC1 process; RPTOR participates as the nutrient-coupled adaptor. Core. |
| GO:0031669 cellular response to nutrient levels | IDA PMID:12747827 TOS motif-mediated raptor binding regulates 4E-BP1 multisite... | ACCEPT | Summary: Nutrient-level response; core. Reason: Cellular response to nutrient levels is the defining mTORC1 process; RPTOR participates as the nutrient-coupled adaptor. Core. |
| GO:0031669 cellular response to nutrient levels | IDA PMID:32561715 Leucine regulates autophagy via acetylation of the mTORC1 co... | ACCEPT | Summary: Nutrient-level response; core. Reason: Cellular response to nutrient levels is the defining mTORC1 process; RPTOR participates as the nutrient-coupled adaptor. Core. |
| GO:0031669 cellular response to nutrient levels | IMP PMID:12150925 mTOR interacts with raptor to form a nutrient-sensitive comp... | ACCEPT | Summary: Nutrient-level response; core. Reason: Cellular response to nutrient levels is the defining mTORC1 process; RPTOR participates as the nutrient-coupled adaptor. Core. |
| GO:0031669 cellular response to nutrient levels | NAS PMID:19299511 Specific activation of mTORC1 by Rheb G-protein in vitro inv... | ACCEPT | Summary: Nutrient-level response; core. Reason: Cellular response to nutrient levels is the defining mTORC1 process; RPTOR participates as the nutrient-coupled adaptor. Core. |
| GO:0031929 TOR signaling | IDA PMID:20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surfac... | ACCEPT | Summary: TOR signaling; core. Reason: TOR signaling is the pathway RPTOR enables as the mTORC1 adaptor subunit. Core. |
| GO:0031929 TOR signaling | IEA GO_REF:0000002 | ACCEPT | Summary: TOR signaling; core. Reason: TOR signaling is the pathway RPTOR enables as the mTORC1 adaptor subunit. Core. |
| GO:0031931 TORC1 complex | IBA GO_REF:0000033 | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:12718876 GbetaL, a positive regulator of the rapamycin-sensitive path... | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ... | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:24036451 PIH1D1 interacts with mTOR complex 1 and enhances ribosome R... | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:24403073 Characterization of the Raptor/4E-BP1 interaction by chemica... | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:25940091 La-related Protein 1 (LARP1) Represses Terminal Oligopyrimid... | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:27909983 4.4 Γ Resolution Cryo-EM structure of human mTOR Complex 1. | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:29236692 Mechanisms of mTORC1 activation by RHEB and inhibition by PR... | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IDA PMID:31601764 Architecture of human Rag GTPase heterodimers and their comp... | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IEA GO_REF:0000002 | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0031931 TORC1 complex | IPI PMID:26678875 Architecture of human mTOR complex 1. | ACCEPT | Summary: TORC1 complex subunit; core. Reason: RPTOR is a defining subunit of mTOR complex 1; part_of TORC1 complex is core. |
| GO:0032008 positive regulation of TOR signaling | IDA PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | ACCEPT | Summary: Positive regulation of TOR signaling; core. Reason: Positive regulation of TOR signaling by RPTOR within mTORC1; core. |
| GO:0032008 positive regulation of TOR signaling | IDA PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoi... | ACCEPT | Summary: Positive regulation of TOR signaling; core. Reason: Positive regulation of TOR signaling by RPTOR within mTORC1; core. |
| GO:0035176 social behavior | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS social-behavior term; over-annotated. Reason: Social behavior (ISS, GO_REF:0000024) is a distal, automatically-propagated organismal phenotype, not a molecular role of RPTOR; over-annotation. |
| GO:0038202 TORC1 signaling | IBA GO_REF:0000033 | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:12747827 TOS motif-mediated raptor binding regulates 4E-BP1 multisite... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:24403073 Characterization of the Raptor/4E-BP1 interaction by chemica... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:26588989 NLK phosphorylates Raptor to mediate stress-induced mTORC1 i... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:26678875 Architecture of human mTOR complex 1. | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:30197302 Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:31112131 GPCR signaling inhibits mTORC1 via PKA phosphorylation of Ra... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:32561715 Leucine regulates autophagy via acetylation of the mTORC1 co... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IDA PMID:35927303 Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 com... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IEA GO_REF:0000117 | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0038202 TORC1 signaling | IMP PMID:12718876 GbetaL, a positive regulator of the rapamycin-sensitive path... | ACCEPT | Summary: TORC1 signaling; core. Reason: TORC1 signaling is the core process RPTOR enables as the mTORC1 adaptor. Core. |
| GO:0043025 neuronal cell body | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Neuronal cell body (IEA); non-core. Reason: Neuronal cell body localisation (IEA) is a neuron-specific electronic annotation; non-core. |
| GO:0044877 protein-containing complex binding | IPI PMID:19211835 Nutrient-dependent mTORC1 association with the ULK1-Atg13-FI... | KEEP AS NON CORE | Summary: Generic complex binding; non-core. Reason: Protein-containing complex binding is accurate but generic; the specific partners (MTOR kinase, Rag GTPases) are captured by precise terms. Non-core. |
| GO:0045672 positive regulation of osteoclast differentiation | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS osteoclast differentiation; over-annotated. Reason: Positive regulation of osteoclast differentiation (ISS) is a distal tissue-level process; over-annotation of a housekeeping growth regulator. |
| GO:0045821 positive regulation of glycolysis | NAS PMID:20670887 Activation of a metabolic gene regulatory network downstream... | KEEP AS NON CORE | Summary: Glycolysis output; non-core. Reason: Positive regulation of glycolysis (NAS) is a downstream metabolic output of mTORC1; non-core. |
| GO:0045945 positive regulation of transcription by RNA polymerase III | IMP PMID:20233713 Requirement of the mTOR kinase for the regulation of Maf1 ph... | KEEP AS NON CORE | Summary: Pol III transcription output; non-core. Reason: Positive regulation of RNA polymerase III transcription is a downstream mTORC1 output; non-core. |
| GO:0046889 positive regulation of lipid biosynthetic process | NAS PMID:20670887 Activation of a metabolic gene regulatory network downstream... | KEEP AS NON CORE | Summary: Lipid-biosynthesis output; non-core. Reason: Positive regulation of lipid biosynthesis (NAS) is a downstream mTORC1 output; non-core. |
| GO:0071230 cellular response to amino acid stimulus | IBA GO_REF:0000033 | ACCEPT | Summary: Amino-acid response; core. Reason: Cellular response to amino acid stimulus is central to mTORC1 nutrient sensing; core. |
| GO:0071230 cellular response to amino acid stimulus | IMP PMID:20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surfac... | ACCEPT | Summary: Amino-acid response; core. Reason: Cellular response to amino acid stimulus is central to mTORC1 nutrient sensing; core. |
| GO:0071233 cellular response to L-leucine | IDA PMID:22424946 Leucyl-tRNA synthetase is an intracellular leucine sensor fo... | ACCEPT | Summary: Leucine response; core. Reason: Cellular response to L-leucine (IDA) is a specific, well-documented mTORC1 nutrient input; core. |
| GO:0071333 cellular response to glucose stimulus | IDA PMID:37541260 O-GlcNAcylation of Raptor transduces glucose signals to mTOR... | ACCEPT | Summary: Glucose response; core. Reason: Cellular response to glucose (IDA, PMID:37541260) couples glucose signals to mTORC1 via RPTOR O-GlcNAcylation; core nutrient sensing. |
| GO:0071456 cellular response to hypoxia | NAS PMID:17041623 Stress and mTORture signaling. | KEEP AS NON CORE | Summary: Hypoxia response; non-core. Reason: Cellular response to hypoxia (NAS) is a distal stress input to mTORC1; non-core. |
| GO:0071470 cellular response to osmotic stress | NAS PMID:17041623 Stress and mTORture signaling. | KEEP AS NON CORE | Summary: Osmotic-stress response; non-core. Reason: Cellular response to osmotic stress (NAS) is a distal stress input; non-core. |
| GO:0071889 14-3-3 protein binding | IDA PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoi... | ACCEPT | Summary: 14-3-3 binding (regulatory); accept. Reason: 14-3-3 protein binding (IDA) mediates phosphorylation-dependent regulation of RPTOR; a specific, documented direct binding. Accept (regulatory, near-core). |
| GO:0140767 enzyme-substrate adaptor activity | IDA PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi... | ACCEPT | Summary: Enzyme-substrate adaptor activity; core. Reason: Enzyme-substrate adaptor activity is RPTOR's defining molecular function: it binds TOS-motif substrates (4E-BP1, S6K1) and presents them to the MTOR kinase. Core. |
| GO:0140767 enzyme-substrate adaptor activity | IDA PMID:12747827 TOS motif-mediated raptor binding regulates 4E-BP1 multisite... | ACCEPT | Summary: Enzyme-substrate adaptor activity; core. Reason: Enzyme-substrate adaptor activity is RPTOR's defining molecular function: it binds TOS-motif substrates (4E-BP1, S6K1) and presents them to the MTOR kinase. Core. Supporting Evidence: PMID:12747827 TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation |
| GO:0140767 enzyme-substrate adaptor activity | IDA PMID:24403073 Characterization of the Raptor/4E-BP1 interaction by chemica... | ACCEPT | Summary: Enzyme-substrate adaptor activity; core. Reason: Enzyme-substrate adaptor activity is RPTOR's defining molecular function: it binds TOS-motif substrates (4E-BP1, S6K1) and presents them to the MTOR kinase. Core. Supporting Evidence: PMID:24403073 Raptor in mTOR complex 1 is believed to recruit 4E-BP1, facilitating phosphorylation of 4E-BP1 by the kinase mTOR. |
| GO:1900087 positive regulation of G1/S transition of mitotic cell cycle | IMP PMID:18426977 eIF4GI links nutrient sensing by mTOR to cell proliferation ... | KEEP AS NON CORE | Summary: G1/S output; non-core. Reason: Positive regulation of G1/S transition is a downstream cell-cycle output of mTORC1; non-core. |
| GO:1901331 positive regulation of odontoblast differentiation | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS odontoblast differentiation; over-annotated. Reason: Positive regulation of odontoblast differentiation (ISS) is a distal tissue-specific process; over-annotation. |
| GO:1905857 positive regulation of pentose-phosphate shunt | NAS PMID:20670887 Activation of a metabolic gene regulatory network downstream... | KEEP AS NON CORE | Summary: Pentose-phosphate output; non-core. Reason: Positive regulation of pentose-phosphate shunt (NAS) is a downstream metabolic output; non-core. |
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