RUNX3

UniProt ID: Q13761
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for RUNX3

Existing Annotations Review

GO Term Evidence Action Reason
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001503 ossification
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030097 hemopoiesis
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030182 neuron differentiation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045595 regulation of cell differentiation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006357 regulation of transcription by RNA polymerase II
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002062 chondrocyte differentiation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003677 DNA binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003700 DNA-binding transcription factor activity
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005524 ATP binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006355 regulation of DNA-templated transcription
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990837 sequence-specific double-stranded DNA binding
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18772112
RUNX3 attenuates beta-catenin/T cell factors in intestinal t... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18772112
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.
GO:0005515 protein binding
IPI
PMID:24229708
Runx3 inactivation is a crucial early event in the developme... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:24229708
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:33961781
2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GO:0005515 protein binding
IPI
PMID:38424632
Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:38424632
Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma.
GO:0005515 protein binding
IPI
PMID:9751710
Transcriptional repression by AML1 and LEF-1 is mediated by ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9751710
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.
GO:0005654 nucleoplasm
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006357 regulation of transcription by RNA polymerase II
IDA
PMID:20591170
The Runx transcriptional co-activator, CBFbeta, is essential... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20591170
The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells.
GO:0001222 transcription corepressor binding
IPI
PMID:9751710
Transcriptional repression by AML1 and LEF-1 is mediated by ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9751710
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.
GO:1990837 sequence-specific double-stranded DNA binding
IDA
PMID:28473536
Impact of cytosine methylation on DNA binding specificities ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:28473536
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
GO:0000785 chromatin
ISA
GO_REF:0000113 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
ISA
GO_REF:0000113 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016513 core-binding factor complex
TAS
PMID:18258917
Repression of the transcription factor Th-POK by Runx comple... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18258917
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952419 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8952399 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8952408 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952382 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952399 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8951966 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8951977 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952058 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952062 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952069 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8937792 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8937807 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8937814 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8865454 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8878117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8878143 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8878178 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8878193 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8878220 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8878237 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8937814 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8949335 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8951428 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8951676 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8951910 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8951951 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952128 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952226 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-8952371 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
GO:0005634 nucleus
IDA
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
GO:0005737 cytoplasm
IDA
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
GO:0045893 positive regulation of DNA-templated transcription
IDA
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
GO:0071559 response to transforming growth factor beta
IDA
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
GO:0005515 protein binding
IPI
PMID:17377532
Foxp3 controls regulatory T-cell function by interacting wit... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17377532
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.
GO:0000785 chromatin
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048935 peripheral nervous system neuron development
TAS
PMID:20096094
Brn3a regulates neuronal subtype specification in the trigem... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20096094
Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.
GO:0005634 nucleus
IDA
PMID:20100835
Src kinase phosphorylates RUNX3 at tyrosine residues and loc... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20100835
Epub 2010 Jan 25. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
GO:0006468 protein phosphorylation
IDA
PMID:20100835
Src kinase phosphorylates RUNX3 at tyrosine residues and loc... 		REMOVE
Summary: MISANNOTATION: RUNX3 is a Runt-domain transcription factor that is extensively PHOSPHORYLATED by kinases. PMID:20100835 title is "Src kinase phosphorylates RUNX3 at tyrosine residues" - RUNX3 is the SUBSTRATE of Src kinase, not an enzyme. The paper states "overexpression of Src results in the tyrosine phosphorylation... of RUNX3" and shows Src phosphorylates RUNX3 in vitro. RUNX3 has DNA-binding and transcription factor activity, not kinase activity. Phosphorylation of RUNX3 by Src leads to its cytoplasmic mislocalization.
Supporting Evidence:
PMID:20100835
Epub 2010 Jan 25. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
GO:0005515 protein binding
IPI
PMID:20100835
Src kinase phosphorylates RUNX3 at tyrosine residues and loc... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20100835
Epub 2010 Jan 25. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
GO:0005737 cytoplasm
IDA
PMID:20100835
Src kinase phosphorylates RUNX3 at tyrosine residues and loc... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20100835
Epub 2010 Jan 25. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
GO:0045786 negative regulation of cell cycle
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050680 negative regulation of epithelial cell proliferation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003700 DNA-binding transcription factor activity
TAS
PMID:7607690
Identification of a new murine runt domain-containing gene, ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7607690
Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter.
GO:0005524 ATP binding
NAS
PMID:7835892
AML1, AML2, and AML3, the human members of the runt domain g... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7835892
AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.
GO:0006355 regulation of DNA-templated transcription
NAS
PMID:7622058
Cloning, mapping and expression of PEBP2 alpha C, a third ge... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7622058
Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000113
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:17377532
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.
PMID:18258917
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.
PMID:18772112
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.
PMID:20096094
Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.
PMID:20100835
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
PMID:20591170
The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells.
PMID:20599712
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
PMID:24229708
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
PMID:28473536
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:38424632
Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma.
PMID:7607690
Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter.
PMID:7622058
Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain.
PMID:7835892
AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.
PMID:9751710
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.
Reactome:R-HSA-8865454
CBFB binds RUNX3
Reactome:R-HSA-8878117
RUNX3 binds ZFHX3
Reactome:R-HSA-8878143
RUNX3 binds SMAD3 and SMAD4
Reactome:R-HSA-8878178
The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter
Reactome:R-HSA-8878193
RUNX3 binds the JAG1 gene promoter
Reactome:R-HSA-8878220
RUNX3 binds the NOTCH1 coactivator complex
Reactome:R-HSA-8878237
RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
Reactome:R-HSA-8937792
RUNX3 binds SRC
Reactome:R-HSA-8937807
SRC phosphorylates RUNX3
Reactome:R-HSA-8937814
RUNX3 translocates to the nucleus
Reactome:R-HSA-8949335
RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter
Reactome:R-HSA-8951428
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)
Reactome:R-HSA-8951676
RUNX3 binds TEADs and YAP1
Reactome:R-HSA-8951910
RUNX3 binds the RUNX1 promoter
Reactome:R-HSA-8951951
RUNX3 binds EP300
Reactome:R-HSA-8951966
EP300 acetylates RUNX3
Reactome:R-HSA-8951977
Acetylated RUNX3 binds to BRD2
Reactome:R-HSA-8952058
CCND1 binds RUNX3 and displaces EP300
Reactome:R-HSA-8952062
CCND1 recruits HDAC4 to RUNX3
Reactome:R-HSA-8952069
HDAC4 deacetylates RUNX3
Reactome:R-HSA-8952128
RUNX3 binds TP53
Reactome:R-HSA-8952226
RUNX3 binds the BCL2L11 (BIM) gene
Reactome:R-HSA-8952371
MDM2 binds RUNX3
Reactome:R-HSA-8952382
MDM2 polyubiquitinates RUNX3
Reactome:R-HSA-8952399
Polyubiquitinated RUNX3 translocates to the cytosol
Reactome:R-HSA-8952408
Polyubiquitinated RUNX3 is degraded by the proteasome
Reactome:R-HSA-8952419
SMURFs ubiquitinate RUNX3

📄 View Raw YAML

 
id: Q13761
gene_symbol: RUNX3
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for RUNX3'
existing_annotations:
  - term:
      id: GO:0000978
      label: RNA polymerase II cis-regulatory region sequence-specific DNA 
        binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001503
      label: ossification
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030097
      label: hemopoiesis
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030182
      label: neuron differentiation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045595
      label: regulation of cell differentiation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006357
      label: regulation of transcription by RNA polymerase II
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000981
      label: DNA-binding transcription factor activity, RNA polymerase 
        II-specific
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002062
      label: chondrocyte differentiation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003677
      label: DNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003700
      label: DNA-binding transcription factor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005524
      label: ATP binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006355
      label: regulation of DNA-templated transcription
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990837
      label: sequence-specific double-stranded DNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18772112
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18772112
          supporting_text: RUNX3 attenuates beta-catenin/T cell factors in 
            intestinal tumorigenesis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24229708
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24229708
          supporting_text: Runx3 inactivation is a crucial early event in the 
            development of lung adenocarcinoma.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:38424632
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:38424632
          supporting_text: Ubiquitylation of RUNX3 by RNA-binding ubiquitin 
            ligase MEX3C promotes tumorigenesis in lung adenocarcinoma.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9751710
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9751710
          supporting_text: Transcriptional repression by AML1 and LEF-1 is 
            mediated by the TLE/Groucho corepressors.
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006357
      label: regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:20591170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20591170
          supporting_text: The Runx transcriptional co-activator, CBFbeta, is 
            essential for invasion of breast cancer cells.
  - term:
      id: GO:0001222
      label: transcription corepressor binding
    evidence_type: IPI
    original_reference_id: PMID:9751710
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9751710
          supporting_text: Transcriptional repression by AML1 and LEF-1 is 
            mediated by the TLE/Groucho corepressors.
  - term:
      id: GO:1990837
      label: sequence-specific double-stranded DNA binding
    evidence_type: IDA
    original_reference_id: PMID:28473536
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28473536
          supporting_text: Impact of cytosine methylation on DNA binding 
            specificities of human transcription factors.
  - term:
      id: GO:0000785
      label: chromatin
    evidence_type: ISA
    original_reference_id: GO_REF:0000113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000981
      label: DNA-binding transcription factor activity, RNA polymerase 
        II-specific
    evidence_type: ISA
    original_reference_id: GO_REF:0000113
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016513
      label: core-binding factor complex
    evidence_type: TAS
    original_reference_id: PMID:18258917
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18258917
          supporting_text: Repression of the transcription factor Th-POK by Runx
            complexes in cytotoxic T cell development.
  - term:
      id: GO:0043371
      label: negative regulation of CD4-positive, alpha-beta T cell 
        differentiation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043378
      label: positive regulation of CD8-positive, alpha-beta T cell 
        differentiation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952419
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952399
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952408
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952382
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952399
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8951966
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8951977
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952062
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952069
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8937792
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8937807
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8937814
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8865454
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8878117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8878143
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8878178
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8878193
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8878220
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8878237
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8937814
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8949335
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8951428
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8951676
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8951910
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8951951
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952128
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952226
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952371
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20599712
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20599712
          supporting_text: Tumor suppressor, AT motif binding factor 1 (ATBF1), 
            translocates to the nucleus with runt domain transcription factor 3 
            (RUNX3) in response to TGF-beta signal transduction.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:20599712
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20599712
          supporting_text: Tumor suppressor, AT motif binding factor 1 (ATBF1), 
            translocates to the nucleus with runt domain transcription factor 3 
            (RUNX3) in response to TGF-beta signal transduction.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:20599712
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20599712
          supporting_text: Tumor suppressor, AT motif binding factor 1 (ATBF1), 
            translocates to the nucleus with runt domain transcription factor 3 
            (RUNX3) in response to TGF-beta signal transduction.
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:20599712
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20599712
          supporting_text: Tumor suppressor, AT motif binding factor 1 (ATBF1), 
            translocates to the nucleus with runt domain transcription factor 3 
            (RUNX3) in response to TGF-beta signal transduction.
  - term:
      id: GO:0071559
      label: response to transforming growth factor beta
    evidence_type: IDA
    original_reference_id: PMID:20599712
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20599712
          supporting_text: Tumor suppressor, AT motif binding factor 1 (ATBF1), 
            translocates to the nucleus with runt domain transcription factor 3 
            (RUNX3) in response to TGF-beta signal transduction.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17377532
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17377532
          supporting_text: Foxp3 controls regulatory T-cell function by 
            interacting with AML1/Runx1.
  - term:
      id: GO:0000785
      label: chromatin
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000977
      label: RNA polymerase II transcription regulatory region sequence-specific
        DNA binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000981
      label: DNA-binding transcription factor activity, RNA polymerase 
        II-specific
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048935
      label: peripheral nervous system neuron development
    evidence_type: TAS
    original_reference_id: PMID:20096094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20096094
          supporting_text: Brn3a regulates neuronal subtype specification in the
            trigeminal ganglion by promoting Runx expression during sensory 
            differentiation.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:20100835
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20100835
          supporting_text: Epub 2010 Jan 25. Src kinase phosphorylates RUNX3 at 
            tyrosine residues and localizes the protein in the cytoplasm.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:20100835
    review:
      summary: >-
        MISANNOTATION: RUNX3 is a Runt-domain transcription factor that is extensively
        PHOSPHORYLATED by kinases. PMID:20100835 title is "Src kinase phosphorylates
        RUNX3 at tyrosine residues" - RUNX3 is the SUBSTRATE of Src kinase, not an
        enzyme. The paper states "overexpression of Src results in the tyrosine
        phosphorylation... of RUNX3" and shows Src phosphorylates RUNX3 in vitro.
        RUNX3 has DNA-binding and transcription factor activity, not kinase activity.
        Phosphorylation of RUNX3 by Src leads to its cytoplasmic mislocalization.
      action: REMOVE
      supported_by:
        - reference_id: PMID:20100835
          supporting_text: Epub 2010 Jan 25. Src kinase phosphorylates RUNX3 at 
            tyrosine residues and localizes the protein in the cytoplasm.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20100835
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20100835
          supporting_text: Epub 2010 Jan 25. Src kinase phosphorylates RUNX3 at 
            tyrosine residues and localizes the protein in the cytoplasm.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:20100835
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20100835
          supporting_text: Epub 2010 Jan 25. Src kinase phosphorylates RUNX3 at 
            tyrosine residues and localizes the protein in the cytoplasm.
  - term:
      id: GO:0045786
      label: negative regulation of cell cycle
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050680
      label: negative regulation of epithelial cell proliferation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003700
      label: DNA-binding transcription factor activity
    evidence_type: TAS
    original_reference_id: PMID:7607690
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7607690
          supporting_text: Identification of a new murine runt domain-containing
            gene, Cbfa3, and localization of the human homolog, CBFA3, to 
            chromosome 1p35-pter.
  - term:
      id: GO:0005524
      label: ATP binding
    evidence_type: NAS
    original_reference_id: PMID:7835892
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7835892
          supporting_text: 'AML1, AML2, and AML3, the human members of the runt domain
            gene-family: cDNA structure, expression, and chromosomal localization.'
  - term:
      id: GO:0006355
      label: regulation of DNA-templated transcription
    evidence_type: NAS
    original_reference_id: PMID:7622058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7622058
          supporting_text: Cloning, mapping and expression of PEBP2 alpha C, a 
            third gene encoding the mammalian Runt domain.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000113
    title: Gene Ontology annotation of human sequence-specific DNA binding 
      transcription factors (DbTFs) based on the TFClass database
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:17377532
    title: Foxp3 controls regulatory T-cell function by interacting with 
      AML1/Runx1.
    findings: []
  - id: PMID:18258917
    title: Repression of the transcription factor Th-POK by Runx complexes in 
      cytotoxic T cell development.
    findings: []
  - id: PMID:18772112
    title: RUNX3 attenuates beta-catenin/T cell factors in intestinal 
      tumorigenesis.
    findings: []
  - id: PMID:20096094
    title: Brn3a regulates neuronal subtype specification in the trigeminal 
      ganglion by promoting Runx expression during sensory differentiation.
    findings: []
  - id: PMID:20100835
    title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes 
      the protein in the cytoplasm.
    findings: []
  - id: PMID:20591170
    title: The Runx transcriptional co-activator, CBFbeta, is essential for 
      invasion of breast cancer cells.
    findings: []
  - id: PMID:20599712
    title: Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to 
      the nucleus with runt domain transcription factor 3 (RUNX3) in response to
      TGF-beta signal transduction.
    findings: []
  - id: PMID:24229708
    title: Runx3 inactivation is a crucial early event in the development of 
      lung adenocarcinoma.
    findings: []
  - id: PMID:28473536
    title: Impact of cytosine methylation on DNA binding specificities of human 
      transcription factors.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:38424632
    title: Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C 
      promotes tumorigenesis in lung adenocarcinoma.
    findings: []
  - id: PMID:7607690
    title: Identification of a new murine runt domain-containing gene, Cbfa3, 
      and localization of the human homolog, CBFA3, to chromosome 1p35-pter.
    findings: []
  - id: PMID:7622058
    title: Cloning, mapping and expression of PEBP2 alpha C, a third gene 
      encoding the mammalian Runt domain.
    findings: []
  - id: PMID:7835892
    title: 'AML1, AML2, and AML3, the human members of the runt domain gene-family:
      cDNA structure, expression, and chromosomal localization.'
    findings: []
  - id: PMID:9751710
    title: Transcriptional repression by AML1 and LEF-1 is mediated by the 
      TLE/Groucho corepressors.
    findings: []
  - id: Reactome:R-HSA-8865454
    title: CBFB binds RUNX3
    findings: []
  - id: Reactome:R-HSA-8878117
    title: RUNX3 binds ZFHX3
    findings: []
  - id: Reactome:R-HSA-8878143
    title: RUNX3 binds SMAD3 and SMAD4
    findings: []
  - id: Reactome:R-HSA-8878178
    title: The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter
    findings: []
  - id: Reactome:R-HSA-8878193
    title: RUNX3 binds the JAG1 gene promoter
    findings: []
  - id: Reactome:R-HSA-8878220
    title: RUNX3 binds the NOTCH1 coactivator complex
    findings: []
  - id: Reactome:R-HSA-8878237
    title: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
    findings: []
  - id: Reactome:R-HSA-8937792
    title: RUNX3 binds SRC
    findings: []
  - id: Reactome:R-HSA-8937807
    title: SRC phosphorylates RUNX3
    findings: []
  - id: Reactome:R-HSA-8937814
    title: RUNX3 translocates to the nucleus
    findings: []
  - id: Reactome:R-HSA-8949335
    title: RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter
    findings: []
  - id: Reactome:R-HSA-8951428
    title: RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)
    findings: []
  - id: Reactome:R-HSA-8951676
    title: RUNX3 binds TEADs and YAP1
    findings: []
  - id: Reactome:R-HSA-8951910
    title: RUNX3 binds the RUNX1 promoter
    findings: []
  - id: Reactome:R-HSA-8951951
    title: RUNX3 binds EP300
    findings: []
  - id: Reactome:R-HSA-8951966
    title: EP300 acetylates RUNX3
    findings: []
  - id: Reactome:R-HSA-8951977
    title: Acetylated RUNX3 binds to BRD2
    findings: []
  - id: Reactome:R-HSA-8952058
    title: CCND1 binds RUNX3 and displaces EP300
    findings: []
  - id: Reactome:R-HSA-8952062
    title: CCND1 recruits HDAC4 to RUNX3
    findings: []
  - id: Reactome:R-HSA-8952069
    title: HDAC4 deacetylates RUNX3
    findings: []
  - id: Reactome:R-HSA-8952128
    title: RUNX3 binds TP53
    findings: []
  - id: Reactome:R-HSA-8952226
    title: RUNX3 binds the BCL2L11 (BIM) gene
    findings: []
  - id: Reactome:R-HSA-8952371
    title: MDM2 binds RUNX3
    findings: []
  - id: Reactome:R-HSA-8952382
    title: MDM2 polyubiquitinates RUNX3
    findings: []
  - id: Reactome:R-HSA-8952399
    title: Polyubiquitinated RUNX3 translocates to the cytosol
    findings: []
  - id: Reactome:R-HSA-8952408
    title: Polyubiquitinated RUNX3 is degraded by the proteasome
    findings: []
  - id: Reactome:R-HSA-8952419
    title: SMURFs ubiquitinate RUNX3
    findings: []