SCGB2A2

Summary: SCGB2A2 is a secreted protein; extracellular space annotation is appropriate.

Reason: Secreted secretoglobins function in the extracellular milieu.

Summary: Phylogenetic annotation seeded by the paralog SCGB2A1 (mammaglobin-B); no SCGB2A2-specific evidence for or against androgen receptor signalling was found.

Reason: The phylogenetic annotation is placed at a node whose recorded evidence is the human paralog SCGB2A1 (mammaglobin-B), so it reflects a curator's judgment that the function is shared by the two mammaglobins. The earlier removal rested on the absence of SCGB2A2-specific evidence, which does not argue against the node placement, and no target-specific evidence of loss or divergence has been examined; the paralog's own evidence was not reviewed here. An inherited annotation is not removed without such an argument, and the row is left undecided.

Summary: Secreted protein localized to the extracellular region.

Reason: Secreted localization is a core feature of mammaglobin-A.

Summary: High-throughput interactome study does not provide gene-specific evidence for SCGB2A2.

Reason: The cached PMID:25416956 text is a global interactome map without SCGB2A2-specific interaction evidence, so this annotation cannot be verified from the publication.

Summary: Secretoglobin family members are reported to bind steroid-like ligands.

Reason: Family-level evidence supports hydrophobic ligand binding as a molecular function.