SCGB2A2 (mammaglobin-A) is a small secreted secretoglobin (lipophilin subfamily) that forms disulfide-linked complexes and is highly expressed in mammary gland tissue. As a secreted secretoglobin, it is expected to bind hydrophobic ligands in extracellular fluids, although specific ligands and direct biochemical activity remain poorly defined.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005615 extracellular space | IBA GO_REF:0000033 | ACCEPT | Summary: SCGB2A2 is a secreted protein; extracellular space annotation is appropriate. Reason: Secreted secretoglobins function in the extracellular milieu. Supporting Evidence: UniProt:Q13296 SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| GO:0030521 androgen receptor signaling pathway | IBA GO_REF:0000033 | REMOVE | Summary: No direct evidence links SCGB2A2 to androgen receptor signaling. Reason: Neither UniProt nor the deep research summary provides evidence for androgen receptor pathway involvement; this appears to be an over-annotation for a secreted secretoglobin. Supporting Evidence: UniProt:Q13296 Belongs to the secretoglobin family. Lipophilin subfamily. |
| GO:0005576 extracellular region | IEA GO_REF:0000044 | ACCEPT | Summary: Secreted protein localized to the extracellular region. Reason: Secreted localization is a core feature of mammaglobin-A. Supporting Evidence: UniProt:Q13296 SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: High-throughput interactome study does not provide gene-specific evidence for SCGB2A2. Reason: The cached PMID:25416956 text is a global interactome map without SCGB2A2-specific interaction evidence, so this annotation cannot be verified from the publication. Supporting Evidence: PMID:25416956 A proteome-scale map of the human interactome network. UniProt:Q13296 Q13296; P50552: VASP; NbExp=3; IntAct=EBI-9058786, EBI-748201; |
| GO:0008289 lipid binding | IEA | NEW | Summary: Secretoglobin family members are reported to bind steroid-like ligands. Reason: Family-level evidence supports hydrophobic ligand binding as a molecular function. Supporting Evidence: file:human/SCGB2A2/SCGB2A2-deep-research-falcon.md Member of the secretoglobin/uteroglobin superfamily; literature describes steroid-like ligand binding as a shared property in the family. |
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