ID   SERP2_HUMAN             Reviewed;          65 AA.
AC   Q8N6R1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   10-JUN-2026, entry version 142.
DE   RecName: Full=Stress-associated endoplasmic reticulum protein 2;
DE   AltName: Full=Ribosome-associated membrane protein RAMP4-2;
GN   Name=SERP2; Synonyms=C13orf21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Interacts with target proteins during their translocation
CC       into the lumen of the endoplasmic reticulum. Protects unfolded target
CC       proteins against degradation during ER stress. May facilitate
CC       glycosylation of target proteins after termination of ER stress. May
CC       modulate the use of N-glycosylation sites on target proteins.
CC       {ECO:0000250|UniProtKB:Q9R2C1}.
CC   -!- SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex.
CC       Interacts with CANX. {ECO:0000250|UniProtKB:Q9R2C1}.
CC   -!- INTERACTION:
CC       Q8N6R1; Q5BKT4: ALG10; NbExp=3; IntAct=EBI-749270, EBI-13064220;
CC       Q8N6R1; Q13520: AQP6; NbExp=3; IntAct=EBI-749270, EBI-13059134;
CC       Q8N6R1; Q13323: BIK; NbExp=3; IntAct=EBI-749270, EBI-700794;
CC       Q8N6R1; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-749270, EBI-11532900;
CC       Q8N6R1; Q9HA82: CERS4; NbExp=3; IntAct=EBI-749270, EBI-2622997;
CC       Q8N6R1; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-749270, EBI-1045797;
CC       Q8N6R1; P49447: CYB561; NbExp=3; IntAct=EBI-749270, EBI-8646596;
CC       Q8N6R1; Q53TN4: CYBRD1; NbExp=3; IntAct=EBI-749270, EBI-8637742;
CC       Q8N6R1; Q15125: EBP; NbExp=3; IntAct=EBI-749270, EBI-3915253;
CC       Q8N6R1; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-749270, EBI-18535450;
CC       Q8N6R1; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-749270, EBI-781551;
CC       Q8N6R1; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-749270, EBI-18938272;
CC       Q8N6R1; P12318-2: FCGR2A; NbExp=3; IntAct=EBI-749270, EBI-17187481;
CC       Q8N6R1; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-749270, EBI-12142257;
CC       Q8N6R1; A2A2Y4: FRMD3; NbExp=3; IntAct=EBI-749270, EBI-6911547;
CC       Q8N6R1; O00258: GET1; NbExp=3; IntAct=EBI-749270, EBI-18908258;
CC       Q8N6R1; Q9NS71: GKN1; NbExp=3; IntAct=EBI-749270, EBI-3933251;
CC       Q8N6R1; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-749270, EBI-13345167;
CC       Q8N6R1; O15529: GPR42; NbExp=3; IntAct=EBI-749270, EBI-18076404;
CC       Q8N6R1; Q8N6L0: KASH5; NbExp=6; IntAct=EBI-749270, EBI-749265;
CC       Q8N6R1; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-749270, EBI-2820517;
CC       Q8N6R1; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-749270, EBI-10329546;
CC       Q8N6R1; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-749270, EBI-373355;
CC       Q8N6R1; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-749270, EBI-3923617;
CC       Q8N6R1; P15941-11: MUC1; NbExp=3; IntAct=EBI-749270, EBI-17263240;
CC       Q8N6R1; O14524-2: NEMP1; NbExp=3; IntAct=EBI-749270, EBI-10969203;
CC       Q8N6R1; P35372-10: OPRM1; NbExp=3; IntAct=EBI-749270, EBI-12807478;
CC       Q8N6R1; O14684: PTGES; NbExp=3; IntAct=EBI-749270, EBI-11161398;
CC       Q8N6R1; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-749270, EBI-10192441;
CC       Q8N6R1; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-749270, EBI-18397230;
CC       Q8N6R1; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-749270, EBI-17247926;
CC       Q8N6R1; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-749270, EBI-18159983;
CC       Q8N6R1; O14863: SLC30A4; NbExp=3; IntAct=EBI-749270, EBI-13918058;
CC       Q8N6R1; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-749270, EBI-9978441;
CC       Q8N6R1; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-749270, EBI-10314552;
CC       Q8N6R1; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-749270, EBI-17498703;
CC       Q8N6R1; P27105: STOM; NbExp=3; IntAct=EBI-749270, EBI-1211440;
CC       Q8N6R1; Q16623: STX1A; NbExp=3; IntAct=EBI-749270, EBI-712466;
CC       Q8N6R1; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-749270, EBI-6268651;
CC       Q8N6R1; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-749270, EBI-13351685;
CC       Q8N6R1; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-749270, EBI-6448756;
CC       Q8N6R1; Q6PL24: TMED8; NbExp=3; IntAct=EBI-749270, EBI-11603430;
CC       Q8N6R1; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-749270, EBI-2821497;
CC       Q8N6R1; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-749270, EBI-8638294;
CC       Q8N6R1; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-749270, EBI-11724423;
CC       Q8N6R1; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-749270, EBI-10982110;
CC       Q8N6R1; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-749270, EBI-11742770;
CC       Q8N6R1; Q9Y320: TMX2; NbExp=3; IntAct=EBI-749270, EBI-6447886;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9R2C1}; Single-
CC       pass membrane protein {ECO:0000250|UniProtKB:Q9R2C1}. Endoplasmic
CC       reticulum membrane {ECO:0000250|UniProtKB:Q9R2C1}; Single-pass membrane
CC       protein {ECO:0000250|UniProtKB:Q9R2C1}.
CC   -!- SIMILARITY: Belongs to the RAMP4 family. {ECO:0000305}.
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DR   EMBL; BC029067; AAH29067.1; -; mRNA.
DR   EMBL; AL138960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS31965.1; -.
DR   RefSeq; NP_001010897.1; NM_001010897.3.
DR   RefSeq; NP_001333909.1; NM_001346980.2.
DR   AlphaFoldDB; Q8N6R1; -.
DR   SMR; Q8N6R1; -.
DR   BioGRID; 132508; 62.
DR   FunCoup; Q8N6R1; 204.
DR   IntAct; Q8N6R1; 55.
DR   STRING; 9606.ENSP00000368477; -.
DR   iPTMnet; Q8N6R1; -.
DR   PhosphoSitePlus; Q8N6R1; -.
DR   BioMuta; SERP2; -.
DR   DMDM; 74751068; -.
DR   jPOST; Q8N6R1; -.
DR   MassIVE; Q8N6R1; -.
DR   PaxDb; 9606-ENSP00000368477; -.
DR   PeptideAtlas; Q8N6R1; -.
DR   ProteomicsDB; 72221; -.
DR   TopDownProteomics; Q8N6R1; -.
DR   Antibodypedia; 77372; 2 antibodies from 2 providers.
DR   DNASU; 387923; -.
DR   Ensembl; ENST00000379179.8; ENSP00000368477.3; ENSG00000151778.12.
DR   Ensembl; ENST00000885982.1; ENSP00000556041.1; ENSG00000151778.12.
DR   GeneID; 387923; -.
DR   KEGG; hsa:387923; -.
DR   MANE-Select; ENST00000379179.8; ENSP00000368477.3; NM_001010897.3; NP_001010897.1.
DR   UCSC; uc001uzj.3; human.
DR   AGR; HGNC:20607; -.
DR   ClinPGx; PA162402953; -.
DR   CTD; 387923; -.
DR   DisGeNET; 387923; -.
DR   GeneCards; SERP2; -.
DR   HGNC; HGNC:20607; SERP2.
DR   HPA; ENSG00000151778; Tissue enhanced (brain, testis).
DR   MalaCards; SERP2; -.
DR   OpenTargets; ENSG00000151778; -.
DR   VEuPathDB; HostDB:ENSG00000151778; -.
DR   eggNOG; KOG3491; Eukaryota.
DR   GeneTree; ENSGT00940000162467; -.
DR   HOGENOM; CLU_160944_3_0_1; -.
DR   InParanoid; Q8N6R1; -.
DR   OMA; KYATTPW; -.
DR   OrthoDB; 16679at2759; -.
DR   PAN-GO; Q8N6R1; 2 GO annotations based on evolutionary models.
DR   PhylomeDB; Q8N6R1; -.
DR   PathwayCommons; Q8N6R1; -.
DR   SignaLink; Q8N6R1; -.
DR   Agora; ENSG00000151778; -.
DR   BioGRID-ORCS; 387923; 18 hits in 1144 CRISPR screens.
DR   ChiTaRS; SERP2; human.
DR   GenomeRNAi; 387923; -.
DR   Pharos; Q8N6R1; Tdark.
DR   PRO; PR:Q8N6R1; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; Q8N6R1; protein.
DR   Bgee; ENSG00000151778; Expressed in Brodmann (1909) area 9 and 130 other cell types or tissues.
DR   ExpressionAtlas; Q8N6R1; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   InterPro; IPR010580; ER_stress-assoc.
DR   PANTHER; PTHR15601; STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4; 1.
DR   PANTHER; PTHR15601:SF20; STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 2; 1.
DR   Pfam; PF06624; RAMP4; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Unfolded protein response.
FT   CHAIN           1..65
FT                   /note="Stress-associated endoplasmic reticulum protein 2"
FT                   /id="PRO_0000274799"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   65 AA;  7431 MW;  4CA89CEF04336C06 CRC64;
     MVAKQRIRMA NEKHSKNITQ RGNVAKTLRP QEEKYPVGPW LLALFVFVVC GSAIFQIIQS
     IRMGM
//