GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q8IUQ4 SIAH1 involved_in GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process ECO:0000318 IBA GO_REF:0000033 FB:FBgn0003410|MGI:MGI:108064|PANTHER:PTN000817023|UniProtKB:Q8IUQ4 9606 Homo sapiens GO_Central E3 ubiquitin-protein ligase SIAH1 20241121 UniProtKB Q8IUQ4 SIAH1 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000318 IBA GO_REF:0000033 FB:FBgn0003410|MGI:MGI:108062|MGI:MGI:108064|PANTHER:PTN000817023|UniProtKB:Q8IUQ4 9606 Homo sapiens GO_Central E3 ubiquitin-protein ligase SIAH1 20241121 UniProtKB Q8IUQ4 SIAH1 is_active_in GO:0005737 cytoplasm cellular_component ECO:0000318 IBA GO_REF:0000033 FB:FBgn0003410|PANTHER:PTN000817023|RGD:620449|RGD:620778|UniProtKB:O43255|UniProtKB:Q8IW03 9606 Homo sapiens GO_Central E3 ubiquitin-protein ligase SIAH1 20230604 UniProtKB Q8IUQ4 SIAH1 enables GO:0031624 ubiquitin conjugating enzyme binding molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000817023|RGD:620778 9606 Homo sapiens GO_Central E3 ubiquitin-protein ligase SIAH1 20180216 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005634 nucleus cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q920M9|ensembl:ENSRNOP00000088384|UniProtKB-SubCell:SL-0191 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20260601 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005737 cytoplasm cellular_component ECO:0000501 IEA GO_REF:0000120 InterPro:IPR018121|UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20260601 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0006511 ubiquitin-dependent protein catabolic process biological_process ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q920M9|ensembl:ENSRNOP00000088384|InterPro:IPR004162|InterPro:IPR018121 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20260601 UniProtKB Q8IUQ4 SIAH1 enables GO:0008270 zinc ion binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR013010 9606 Homo sapiens InterPro E3 ubiquitin-protein ligase SIAH1 20260601 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0060070 canonical Wnt signaling pathway biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00026624 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20260601 UniProtKB Q8IUQ4 SIAH1 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000501 IEA GO_REF:0000003 EC:2.3.2.27 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20260601 UniProtKB Q8IUQ4 SIAH1 involved_in GO:1990000 amyloid fibril formation biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00087261 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20260601 UniProtKB Q8IUQ4 SIAH1 involved_in GO:2001233 regulation of apoptotic signaling pathway biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00027033 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20260601 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:11483518 UniProtKB:Q16633 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:11483518 UniProtKB:Q64693 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:16230351 UniProtKB:Q69ZI1 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19549727 UniProtKB:P61086 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21078624 UniProtKB:O15265 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21185211 UniProtKB:O43236-6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21185211 UniProtKB:P98170 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21516116 UniProtKB:Q8IXK0 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21516116 UniProtKB:Q9UHX1 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21878328 UniProtKB:P69713 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21988832 UniProtKB:P29692 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21988832 UniProtKB:Q8IXK0 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21988832 UniProtKB:Q99836 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21988832 UniProtKB:Q9UHX1 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23840749 UniProtKB:P35372 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:A2RRL9 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O00560 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O14645 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O43581 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O60333 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O60336 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O95045 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P05111 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P08237 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P11216 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P14373 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P20591 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P29692 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P29972 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P36406 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P40121 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P41182 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P49427 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P53778 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P61086 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P62805 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P78508 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P86479 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q01543 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q13394 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q13625-3 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q14088 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q2TAL8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q53H82 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q59GP6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q5T5P2-6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q6FIE9 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q70IA8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q7Z3E5-2 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q86TG7 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q86WX3 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q86YD7 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8IXK0 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8IZA0 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8N2X6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8N619 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8NEY3 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8TAM4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8TAN2 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8TBK6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8WTR4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8WUK0 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8WW36 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8WWY3 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q92692 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q96B01 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q96B01-2 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q96DC9 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q96HA8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q96KM6 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9BQ24 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9BTV4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9BVG8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9BW62 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9C029 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9H0A9 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9H0B3 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9H2K0 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9H3P2 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9H6R4-4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9NRN7 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9NU19 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9NVL8 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UBK9 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UHB7 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UHB7-2 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UHX1 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UJV9 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UJX2 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UQR1 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9Y4B4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9Y5T4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:21988832 UniProtKB:Q8IUQ4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:22493164 UniProtKB:Q8IUQ4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8IUQ4 9606 Homo sapiens IntAct E3 ubiquitin-protein ligase SIAH1 20260530 UniProtKB Q8IUQ4 SIAH1 enables GO:0004842 ubiquitin-protein transferase activity molecular_function ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q920M9|ensembl:ENSRNOP00000088384 9606 Homo sapiens Ensembl E3 ubiquitin-protein ligase SIAH1 20260529 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005769 early endosome cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q920M9|ensembl:ENSRNOP00000088384 9606 Homo sapiens Ensembl E3 ubiquitin-protein ligase SIAH1 20260529 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q920M9|ensembl:ENSRNOP00000088384 9606 Homo sapiens Ensembl E3 ubiquitin-protein ligase SIAH1 20260529 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0031648 protein destabilization biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q920M9|ensembl:ENSRNOP00000088384 9606 Homo sapiens Ensembl E3 ubiquitin-protein ligase SIAH1 20260529 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0051402 neuron apoptotic process biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q920M9|ensembl:ENSRNOP00000088384 9606 Homo sapiens Ensembl E3 ubiquitin-protein ligase SIAH1 20260529 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0016567 protein ubiquitination biological_process ECO:0007322 IEA GO_REF:0000041 UniPathway:UPA00143 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20260227 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005654 nucleoplasm cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA E3 ubiquitin-protein ligase SIAH1 20251115 UniProtKB Q8IUQ4 SIAH1 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000269 EXP PMID:19224863 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20251027 UniProtKB Q8IUQ4 SIAH1 enables GO:0004842 ubiquitin-protein transferase activity molecular_function ECO:0000304 TAS Reactome:R-HSA-5660753 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20240514 UniProtKB Q8IUQ4 SIAH1 enables GO:0004842 ubiquitin-protein transferase activity molecular_function ECO:0000304 TAS Reactome:R-HSA-5667107 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20240514 UniProtKB Q8IUQ4 SIAH1 involved_in GO:1990000 amyloid fibril formation biological_process ECO:0000304 TAS Reactome:R-HSA-977225 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20230308 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33591310 UniProtKB:Q15038 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20220620 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process ECO:0000314 IDA PMID:33591310 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20220620 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process ECO:0000315 IMP PMID:28546513 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20211216 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0060070 canonical Wnt signaling pathway biological_process ECO:0000315 IMP PMID:28546513 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20211216 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0060070 canonical Wnt signaling pathway biological_process ECO:0000315 IMP PMID:32430360 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20211216 UniProtKB Q8IUQ4 SIAH1 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000315 IMP PMID:28546513 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20211216 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:28546513 UniProtKB:O15169 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20211207 UniProtKB Q8IUQ4 SIAH1 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000314 IDA PMID:23001567 9606 Homo sapiens MGI E3 ubiquitin-protein ligase SIAH1 20141024 UniProtKB Q8IUQ4 SIAH1 involved_in GO:2001244 positive regulation of intrinsic apoptotic signaling pathway biological_process ECO:0000315 IMP PMID:21185211 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20141009 UniProtKB Q8IUQ4 SIAH1 acts_upstream_of_or_within GO:0006511 ubiquitin-dependent protein catabolic process biological_process ECO:0000314 IDA PMID:23001567 9606 Homo sapiens MGI E3 ubiquitin-protein ligase SIAH1 20131106 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-374665 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5658092 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5658496 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5660753 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5660757 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5667107 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-983140 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-983147 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-983156 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-983157 9606 Homo sapiens Reactome E3 ubiquitin-protein ligase SIAH1 20130528 UniProtKB Q8IUQ4 SIAH1 enables GO:0004842 ubiquitin-protein transferase activity molecular_function ECO:0000315 IMP PMID:21185211 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20111220 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0043065 positive regulation of apoptotic process biological_process ECO:0000314 IDA PMID:21185211 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20110815 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005634 nucleus cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q920M9 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20101123 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0051402 neuron apoptotic process biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q920M9 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20101123 UniProtKB Q8IUQ4 SIAH1 enables GO:0004842 ubiquitin-protein transferase activity molecular_function ECO:0000250 ISS GO_REF:0000024 UniProtKB:P61092 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20100205 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0006511 ubiquitin-dependent protein catabolic process biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:P61092 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20100205 UniProtKB Q8IUQ4 SIAH1 enables GO:0008270 zinc ion binding molecular_function ECO:0000250 ISS GO_REF:0000024 UniProtKB:P61092 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20100205 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:P61092 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20100205 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:16085652 UniProtKB:Q9HB71 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20091119 UniProtKB Q8IUQ4 SIAH1 enables GO:0008270 zinc ion binding molecular_function ECO:0000314 IDA PMID:16085652 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20091119 UniProtKB Q8IUQ4 SIAH1 part_of GO:0030877 beta-catenin destruction complex cellular_component ECO:0000314 IDA PMID:16085652 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20091119 UniProtKB Q8IUQ4 SIAH1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:11389840 UniProtKB:P25054 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20070402 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0030163 protein catabolic process biological_process ECO:0000314 IDA PMID:11389840 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20070402 UniProtKB Q8IUQ4 SIAH1 located_in GO:0005737 cytoplasm cellular_component ECO:0000304 TAS PMID:9334332 9606 Homo sapiens PINC E3 ubiquitin-protein ligase SIAH1 20050308 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0006915 apoptotic process biological_process ECO:0000304 TAS PMID:9403064 9606 Homo sapiens PINC E3 ubiquitin-protein ligase SIAH1 20050308 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0007399 nervous system development biological_process ECO:0000304 TAS PMID:9334332 9606 Homo sapiens PINC E3 ubiquitin-protein ligase SIAH1 20050308 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0007411 axon guidance biological_process ECO:0000304 TAS PMID:9334332 9606 Homo sapiens PINC E3 ubiquitin-protein ligase SIAH1 20050308 UniProtKB Q8IUQ4 SIAH1 involved_in GO:0009653 anatomical structure morphogenesis biological_process ECO:0000304 TAS PMID:9403064 9606 Homo sapiens PINC E3 ubiquitin-protein ligase SIAH1 20050308 UniProtKB Q8IUQ4 SIAH1 enables GO:0008270 zinc ion binding molecular_function ECO:0000314 IDA PMID:11863358 9606 Homo sapiens UniProt E3 ubiquitin-protein ligase SIAH1 20040929