SMIM13

SMIM13 (formerly C6orf228) is a 91-amino-acid (about 10.4 kDa) protein of the SMIM13 family (Pfam DUF4750). It has a single predicted transmembrane helix near the N terminus (residues 10-30), and its C-terminal half (residues 47-91) is predicted to be intrinsically disordered, with basic and mixed-charge stretches; four serine/threonine residues in this tail are annotated as phosphorylation sites by similarity to the mouse protein. The transcript is detected in all tissues and is enriched in brain. Antibody staining in the Human Protein Atlas gives nucleoplasm as the main signal, with nuclear membrane and Golgi apparatus as additional locations; the membrane in which the protein actually resides has not been established by an orthogonal method. No molecular activity, interaction partner or biological process has been reported for SMIM13.