SNCA encodes alpha-synuclein, a small (140-residue), highly conserved, intrinsically disordered neuronal protein that is abundant at presynaptic nerve terminals and also present in the neuronal cytosol and nucleus. Its N-terminal region contains imperfect 11-residue KTKEGV repeats that fold into an amphipathic alpha-helix upon binding curved, negatively charged phospholipid membranes, while the acidic C-terminal tail remains unstructured and binds calcium and other ligands; a high-affinity N-terminal copper site (Met1, Asp2, His50) is a robust biochemical feature. At the presynapse, membrane-bound multimeric alpha-synuclein acts as a nonclassical chaperone that binds the v-SNARE VAMP2/synaptobrevin-2 and promotes assembly of the SNARE complex, cooperating with CSPalpha/DNAJC5; synuclein triple-knockout mice show age-dependent neurological decline and reduced SNARE assembly. Alpha-synuclein modulates synaptic vesicle trafficking, priming, exocytotic fusion-pore dilation and endocytic recycling, and regulates dopaminergic neurotransmission, in part by modulating the dopamine transporter and other monoamine transporters. It binds tubulin and influences microtubule dynamics, and interacts with tau. Alpha-synuclein is the principal component of Lewy bodies and glial cytoplasmic inclusions: it self-associates into oligomers and amyloid fibrils, and point mutations (A30P, E46K, H50Q, A53T) or SNCA multiplication cause familial Parkinson disease, with aggregated forms central to Parkinson disease, dementia with Lewy bodies and multiple system atrophy.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000122 negative regulation of transcription by RNA polymerase II | TAS PMID:24252804 The role of oxidative stress in Parkinson's disease. | MARK AS OVER ANNOTATED | Summary: TAS from a review of oxidative stress in PD; the review mentions stress-induced nuclear alpha-synuclein binding the PGC1alpha promoter. Reason: Repression of RNA polymerase II transcription rests on a stress-induced nuclear pool of alpha-synuclein reported in a few studies and summarized in this review; alpha-synuclein has no DNA-binding domain and its established physiological activities are presynaptic membrane and SNARE chaperone functions. Nuclear effects on gene expression are a disease-context observation, so the process claim exceeds the evidence. Supporting Evidence: PMID:24252804 PD causing gene products including DJ-1, PINK1, parkin, alpha-synuclein and LRRK2 also impact in complex ways mitochondrial function leading to exacerbation of ROS generation and susceptibility to oxidative stress. PMID:16959795 alpha-synuclein localizes to the nucleus and presynaptic nerve terminals |
| GO:0000149 SNARE binding | IDA PMID:20798282 Alpha-synuclein promotes SNARE-complex assembly in vivo and ... | ACCEPT | Summary: Burre et al. showed direct binding of alpha-synuclein to the SNARE protein VAMP2 (synaptobrevin-2) and promotion of SNARE-complex assembly. Reason: Direct binding to VAMP2 via the C-terminal tail is the molecular basis of the best-supported physiological activity of alpha-synuclein, the nonclassical SNARE-chaperone function. SNARE binding is a core molecular function. Supporting Evidence: PMID:20798282 Ξ±-synuclein directly bound to the SNARE-protein synaptobrevin-2/vesicle-associated membrane protein 2 (VAMP2) and promoted SNARE-complex assembly |
| GO:0000287 magnesium ion binding | IDA PMID:11850416 Magnesium inhibits spontaneous and iron-induced aggregation ... | KEEP AS NON CORE | Summary: Golts et al. used tyrosine fluorescence to show Mg2+-induced conformational change and Mg2+ inhibition of aggregation in vitro. Reason: Binding of Mg2+ is shown only indirectly (fluorescence change at sub-mM to mM concentrations) and relates to aggregation in vitro. The binding claim is acceptable but peripheral to function. Supporting Evidence: PMID:11850416 we show that iron and magnesium both interact with alpha-synuclein PMID:11850416 These data suggest that the conformation of alpha-synuclein can be modulated by metals, with iron promoting aggregation and magnesium inhibiting aggregation. |
| GO:0000976 transcription cis-regulatory region binding | TAS PMID:24252804 The role of oxidative stress in Parkinson's disease. | MARK AS OVER ANNOTATED | Summary: TAS from a review of oxidative stress in PD; sequence-specific DNA binding by alpha-synuclein is reported only for stress-induced nuclear protein binding the PGC1alpha promoter. Reason: alpha-synuclein lacks a recognised DNA-binding domain; reported promoter occupancy comes from single studies of stressed or overexpressing cells. The molecular-function claim exceeds what has been established. Supporting Evidence: PMID:24252804 PD causing gene products including DJ-1, PINK1, parkin, alpha-synuclein and LRRK2 also impact in complex ways mitochondrial function leading to exacerbation of ROS generation and susceptibility to oxidative stress. |
| GO:0001774 microglial cell activation | TAS PMID:24252804 The role of oxidative stress in Parkinson's disease. | MARK AS OVER ANNOTATED | Summary: TAS from a review: extracellular aggregated, nitrated or mutant alpha-synuclein released from neurons activates microglia. Reason: Microglial activation is a response of microglia to pathological extracellular alpha-synuclein species (e.g. as a TLR2 agonist); it is a disease mechanism rather than a normal function of the neuronal protein, so the process annotation is an over-annotation. Supporting Evidence: PMID:24252804 PD causing gene products including DJ-1, PINK1, parkin, alpha-synuclein and LRRK2 also impact in complex ways mitochondrial function leading to exacerbation of ROS generation and susceptibility to oxidative stress. |
| GO:0001921 positive regulation of receptor recycling | IDA PMID:18980610 Alpha-synuclein and polyunsaturated fatty acids promote clat... | MARK AS OVER ANNOTATED | Summary: Ben Gedalya et al. showed that alpha-synuclein with PUFAs enhances clathrin-mediated endocytosis and transferrin internalization. Reason: The paper measures internalization (FM1-43, transferrin) rather than receptor recycling back to the surface; the endocytosis-related terms (receptor internalization, positive regulation of endocytosis) capture the finding. Positive regulation of receptor recycling goes beyond what was measured. Supporting Evidence: PMID:18980610 alphaS expression coupled with exposure to physiological levels of certain PUFAs enhanced clathrin-mediated endocytosis in neuronal and non-neuronal cultured cells PMID:18980610 We suggest that alphaS and PUFAs normally function in endocytic mechanisms and are specifically involved in SV recycling upon neuronal stimulation. |
| GO:0001963 synaptic transmission, dopaminergic | IBA GO_REF:0000033 | ACCEPT | Summary: IBA from PANTHER node PTN009013518 with mouse Snca as experimental donor; Snca-null mice show altered activity-dependent dopamine release. Reason: Knockout mice show altered paired-pulse dopamine release in nigrostriatal terminals, and the protein modulates the DAT and dopamine release; the phylogenetic placement within the alpha-synuclein clade is sound. Supporting Evidence: PMID:10707987 alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission |
| GO:0003779 actin binding | IPI PMID:18331289 Regulated interactions of the norepineprhine transporter by ... | KEEP AS NON CORE | Summary: Jeannotte and Sidhu reported NET, beta-actin and alpha-synuclein co-association that is modified by actin depolymerization. Reason: Association with actin is reported (also by FRET in PMID:17408955) and may be indirect; it is not central to the presynaptic function. Supporting Evidence: PMID:18331289 Protein interactions between NET, beta-actin, and alpha-Syn were modified, along with levels of surface transporters. PMID:17408955 alpha-synuclein associates with the actin cytoskeleton and interacts with tau |
| GO:0004857 enzyme inhibitor activity | IDA PMID:11943812 A role for alpha-synuclein in the regulation of dopamine bio... | KEEP AS NON CORE | Summary: Perez et al. showed dose-dependent inhibition of tyrosine hydroxylase by recombinant alpha-synuclein in a cell-free assay. Reason: Inhibition of TH activity in vitro is direct evidence for an enzyme inhibitor activity, but the physiological significance is uncertain and it is peripheral to the synaptic vesicle function. Supporting Evidence: PMID:11943812 observed a dose-dependent inhibition of tyrosine hydroxylase by alpha-synuclein |
| GO:0004860 protein kinase inhibitor activity | TAS PMID:30194957 Ξ±-synuclein expression from a single copy transgene increase... | MARK AS OVER ANNOTATED | Summary: TAS from a C. elegans single-copy-transgene study that mentions, as background, earlier yeast work showing alpha-synuclein inhibits Cdc5/Plk2 signalling. Reason: The cited paper does not test kinase inhibition; the statement refers to a yeast study. In mammalian neurons PLK2 phosphorylates alpha-synuclein (PMID:23983262), i.e. alpha-synuclein is a kinase substrate, and direct kinase inhibitor activity has not been established. Supporting Evidence: PMID:30194957 previous work has shown that Ξ±-synuclein can disrupt stress signaling through the inhibition of the kinase Cdc5/Plk2 PMID:23983262 PLK2 overexpression reduces intraneuronal human Ξ±-synuclein accumulation |
| GO:0004869 cysteine-type endopeptidase inhibitor activity | IDA PMID:10818098 Wild-type but not Parkinson's disease-related ala-53 --> Thr... | MARK AS OVER ANNOTATED | Summary: da Costa et al. found lower caspase activation in TSM1 neurons overexpressing wild-type alpha-synuclein after apoptotic stimuli. Reason: The abstract reports reduced cellular caspase activation, an indirect readout of an anti-apoptotic effect, not direct inhibition of a cysteine-type endopeptidase by alpha-synuclein. The full text is not available in the cache, so this rests on the abstract; without direct enzyme-inhibition data the molecular-function term exceeds the evidence. Supporting Evidence: PMID:10818098 wt alpha-synuclein drastically reduces the caspase activation of TSM1 neurons upon three distinct apoptotic stimuli PMID:10818098 wild-type alpha-synuclein exerts an antiapoptotic effect in neurons |
| GO:0005504 fatty acid binding | IDA NOT PMID:16687662 Interactions between fatty acids and alpha-synuclein. | KEEP AS NON CORE | Summary: NOT annotation: Lucke et al. found no high-affinity specific fatty-acid binding sites in alpha-synuclein by NMR. Reason: The paper excludes FABP-like specific fatty acid binding and concludes alpha-synuclein is not an intracellular FA carrier, while showing interaction with negatively charged FA aggregates as membranes. The negative statement is supported; peripheral to core function. Supporting Evidence: PMID:16687662 We conclude that alphaS is not likely to act as an intracellular FA carrier. PMID:16687662 Binding to negatively charged membranes, however, appears to be an intrinsic property of alphaS that is most likely related to its physiological role(s) in the cell. |
| GO:0005507 copper ion binding | IDA PMID:21319811 Coordination features and affinity of the CuΒ²+ site in the Ξ±... | KEEP AS NON CORE | Summary: Dudzik et al. measured by EPR a 1:1 Cu(II) complex at the N-terminus/Asp2/His50 with Kd about 0.1 nM. Reason: High-affinity Cu(II) binding is robust biochemistry, but its physiological role (copper sequestration, redox modulation) is not established. Keep as non-core. Supporting Evidence: PMID:21319811 Ξ±-syn binds Cu(2+) with a K(d) of β0.10 nM PMID:21319811 suggests that copper uptake and sequestration may be a part of Ξ±-syn's natural function |
| GO:0005507 copper ion binding | IDA PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | KEEP AS NON CORE | Summary: Meloni and Vasak studied the alpha-Syn-Cu(II) complex; copper binding is implied by the redox-chemistry assay. Reason: This bioinorganic study assays Cu(II) bound to alpha-synuclein; copper binding is well supported but peripheral to the physiological presynaptic function. One of two copper-binding rows. Supporting Evidence: PMID:21320589 The observed metal-centered redox chemistry significantly promotes the production of hydroxyl radicals and Ξ±-Syn oxidation and oligomerization PMID:21320589 These studies provide new insights into the bioinorganic chemistry of PD. |
| GO:0005509 calcium ion binding | IDA PMID:11312271 Ca2+ binding to alpha-synuclein regulates ligand binding and... | KEEP AS NON CORE | Summary: Nielsen et al. mapped Ca2+ binding to a C-terminal acidic 32-aa domain by microdialysis. Reason: Ca2+ binding to the acidic C-terminal tail is directly demonstrated and modulates oligomerization/ligand binding; it is a genuine but peripheral biochemical property. Supporting Evidence: PMID:11312271 The Ca(2+)-binding site consists of a novel C-terminally localized acidic 32-amino acid domain |
| GO:0005509 calcium ion binding | IDA PMID:11850416 Magnesium inhibits spontaneous and iron-induced aggregation ... | KEEP AS NON CORE | Summary: Golts et al. inferred metal binding, including calcium context, from tyrosine-fluorescence conformational changes. Reason: A second calcium-binding row; the fluorescence study mainly addresses Fe/Mg effects on aggregation, so this is weaker support for Ca2+ binding than PMID:11312271. Non-core. Supporting Evidence: PMID:11850416 we show that iron and magnesium both interact with alpha-synuclein |
| GO:0005515 protein binding | IPI PMID:10319874 Synphilin-1 associates with alpha-synuclein and promotes the... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:11943812 A role for alpha-synuclein in the regulation of dopamine bio... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:11956199 Synphilin-1 is developmentally localized to synaptic termina... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:12044636 Analysis of synphilin-1 and synuclein interactions by yeast ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:12059041 Mutant and wild-type alpha-synuclein interact with mitochond... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:12958153 Modulation of dopamine transporter function by alpha-synucle... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:15207266 Abnormal alpha-synuclein interactions with rab3a and rabphil... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:15207266 Abnormal alpha-synuclein interactions with rab3a and rabphil... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:15207266 Abnormal alpha-synuclein interactions with rab3a and rabphil... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:15207266 Abnormal alpha-synuclein interactions with rab3a and rabphil... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:15590652 p25alpha Stimulates alpha-synuclein aggregation and is co-lo... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:15671022 Heat shock protein 70 inhibits alpha-synuclein fibril format... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:15671022 Heat shock protein 70 inhibits alpha-synuclein fibril format... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:16595633 Synphilin-1A: an aggregation-prone isoform of synphilin-1 th... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:16882008 Modulation of the trafficking of the human serotonin transpo... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:17027006 Interaction of TPPP/p25 protein with glyceraldehyde-3-phosph... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:17156375 Attenuation of the norepinephrine transporter activity and t... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:18331289 Regulated interactions of the norepineprhine transporter by ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:19549071 Functional dissection of the alpha-synuclein promoter: trans... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:19549071 Functional dissection of the alpha-synuclein promoter: trans... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:19549071 Functional dissection of the alpha-synuclein promoter: trans... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:19762560 Interaction with synphilin-1 promotes inclusion formation of... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:20798282 Alpha-synuclein promotes SNARE-complex assembly in vivo and ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:20798282 Alpha-synuclein promotes SNARE-complex assembly in vivo and ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:21798244 Human Ξ±-synuclein modulates vesicle trafficking through its ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:21985244 Stimulatory effect of Ξ±-synuclein on the tau-phosphorylation... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:21985244 Stimulatory effect of Ξ±-synuclein on the tau-phosphorylation... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:22119730 Ξ±-Synuclein modifies huntingtin aggregation in living cells. | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:22163275 Redistribution of DAT/Ξ±-synuclein complexes visualized by "i... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:22163275 Redistribution of DAT/Ξ±-synuclein complexes visualized by "i... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:22854022 SERF protein is a direct modifier of amyloid fiber assembly. | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:22854022 SERF protein is a direct modifier of amyloid fiber assembly. | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:23183827 LRRK2 interactions with Ξ±-synuclein in Parkinson's disease b... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:24412932 c-Abl phosphorylates Ξ±-synuclein and regulates its degradati... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:24412932 c-Abl phosphorylates Ξ±-synuclein and regulates its degradati... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:24895406 The chaperone-like protein 14-3-3Ξ· interacts with human Ξ±-sy... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:26643113 Ξ±-synuclein interacts with SOD1 and promotes its oligomeriza... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:26921451 Effects of different isoforms of apoE on aggregation of the ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:27348587 Activation of tyrosine kinase c-Abl contributes to Ξ±-synucle... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:27671864 Challenging drug target for Parkinson's disease: Pathologica... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:28887769 Ξ±-Synuclein Interacts with Lipoproteins in Plasma. | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:28887769 Ξ±-Synuclein Interacts with Lipoproteins in Plasma. | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:28887769 Ξ±-Synuclein Interacts with Lipoproteins in Plasma. | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:31034892 Increased Aggregation Tendency of Alpha-Synuclein in a Fully... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:31270237 Ξ±-synuclein-lipoprotein interactions and elevated ApoE level... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:31270237 Ξ±-synuclein-lipoprotein interactions and elevated ApoE level... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:31270237 Ξ±-synuclein-lipoprotein interactions and elevated ApoE level... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:34860005 Interactions between SARS-CoV-2 N-Protein and Ξ±-Synuclein Ac... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005515 protein binding | IPI PMID:35063084 Tau interactome maps synaptic and mitochondrial processes as... | REMOVE | Summary: Generic protein binding (GO:0005515) from an interaction assay; most are from a single large yeast two-hybrid / interactome screen (PMID:32814053). Reason: Per the protein-binding policy, bare GO:0005515 carries no functional information and is removed (removal does not assert the interaction is false). alpha-synuclein's informative binding activities are captured by specific terms retained in this review: SNARE binding (GO:0000149), lipid/phospholipid binding (GO:0008289/GO:0005543), tubulin/microtubule binding, histone binding, tau binding, Hsp70 binding, metal-ion binding, and identical-protein binding. |
| GO:0005543 phospholipid binding | IDA PMID:17222866 Relationships between the sequence of alpha-synuclein and it... | ACCEPT | Summary: Volles and Lansbury; many non-toxic mutants have membrane-binding defects, confirming phospholipid/membrane binding as an intrinsic property. Reason: Phospholipid binding by the N-terminal amphipathic helix is a core molecular function underlying the SNARE-chaperone and vesicle roles. IDA supported. Supporting Evidence: PMID:11286556 The N-terminal region of alphaS binds to synthetic lipid vesicles and detergent micelles in vitro and adopts a highly helical conformation PMID:17222866 Most of these contained a mutation to either proline or glutamic acid that caused a defect in membrane binding. |
| GO:0005543 phospholipid binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (GO_REF:0000107, Ensembl Compara from rat P37377) for phospholipid binding. Reason: Consistent with the experimentally supported phospholipid binding; the electronic transfer from the rat ortholog is correct. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat alpha-synuclein ortholog; phospholipid binding is a conserved intrinsic property of the amphipathic N-terminus. |
| GO:0005576 extracellular region | IDA PMID:15863497 Proteolytic cleavage of extracellular secreted {alpha}-synuc... | KEEP AS NON CORE | Summary: Sung et al. showed transfected alpha-synuclein is secreted into culture medium and cleaved extracellularly by MMP-3. Reason: A secreted/extracellular pool exists and is relevant to intercellular propagation, but the protein is predominantly intracellular/presynaptic. Location is non-core. One of several extracellular-region rows. Supporting Evidence: PMID:15863497 When SK-N-BE cells were transiently transfected with alpha-synuclein, it was secreted into the extracellular culture media |
| GO:0005576 extracellular region | IDA PMID:24936070 The H50Q mutation enhances Ξ±-synuclein aggregation, secretio... | KEEP AS NON CORE | Summary: Khalaf et al.: the H50Q mutation increased secretion of alpha-synuclein into culture medium. Reason: Supports an extracellular pool (secretion), consistent with PMID:15863497; non-core location. Supporting Evidence: PMID:24936070 H50Q increased Ξ±-Syn secretion from SHSY5Y cells into culture medium |
| GO:0005576 extracellular region | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA from the UniProt subcellular-location keyword 'Secreted' (SL-0243). Reason: Consistent with the experimentally observed secreted pool; keep as non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB-SubCell:SL-0243 SUPPORTS TRANSFER UniProt Secreted keyword, grounded in experimental secretion (PMID:15863497, PMID:24936070). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-976734 | KEEP AS NON CORE | Summary: Reactome TAS (amyloid fibrils have additional components) places alpha-synuclein fibrils in the extracellular region. Reason: Reactome models extracellular amyloid-fibril biology; an extracellular pool is supported, peripheral to the core presynaptic function. Supporting Evidence: Reactome:R-HSA-976734 additional components |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-977136 | KEEP AS NON CORE | Summary: Reactome TAS (amyloid precursor proteins form ordered fibrils). Reason: As above; extracellular localization in the amyloid context, non-core. Supporting Evidence: Reactome:R-HSA-977136 fibril formation |
| GO:0005634 nucleus | EXP PMID:12859192 Nuclear localization of alpha-synuclein and its interaction ... | KEEP AS NON CORE | Summary: Goers et al.: EXP nuclear localization of alpha-synuclein with histone co-localization in nigral neurons. Reason: A nuclear pool is observed experimentally (also PMID:16959795, PMID:24936070). It is a genuine minor localization but peripheral to the presynaptic core function and largely studied in stress/disease contexts. Non-core. Supporting Evidence: PMID:12859192 We also describe the presence of alpha-synuclein and its co-localization with histones in the nuclei of nigral neurons |
| GO:0005634 nucleus | IDA PMID:12406186 Upregulation of alpha-synuclein by lipopolysaccharide and in... | KEEP AS NON CORE | Summary: Kontopoulos et al.: IDA nuclear localization; alpha-synuclein binds histones in the nucleus. Reason: Nuclear pool directly observed; non-core location. Supporting Evidence: PMID:16959795 alpha-synuclein localizes to the nucleus and presynaptic nerve terminals |
| GO:0005634 nucleus | IDA PMID:16959795 Alpha-synuclein acts in the nucleus to inhibit histone acety... | KEEP AS NON CORE | Summary: Kontopoulos et al.: IDA nuclear localization (same study as histone binding). Reason: Duplicate nuclear-localization support; non-core. Supporting Evidence: PMID:16959795 alpha-synuclein localizes to the nucleus and presynaptic nerve terminals |
| GO:0005634 nucleus | IDA PMID:17408955 alpha-Synuclein and its disease-related mutants interact dif... | KEEP AS NON CORE | Summary: Esposito et al.: IDA; alpha-synuclein associates with nuclear/cytoskeletal compartments. Reason: Supports the minor nuclear pool; non-core. Supporting Evidence: PMID:17408955 alpha-synuclein associates with the actin cytoskeleton and interacts with tau |
| GO:0005634 nucleus | IDA PMID:24936070 The H50Q mutation enhances Ξ±-synuclein aggregation, secretio... | KEEP AS NON CORE | Summary: Khalaf et al.: IDA; alpha-synuclein nuclear localization unaffected by H50Q. Reason: Consistent nuclear pool; non-core. Supporting Evidence: PMID:24936070 In cell-based models, H50Q mutation did not affect Ξ±-Syn subcellular localization |
| GO:0005634 nucleus | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA from UniProt subcellular-location keyword Nucleus (SL-0191). Reason: Consistent with the experimentally observed nuclear pool; non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB-SubCell:SL-0191 SUPPORTS TRANSFER UniProt Nucleus keyword, grounded in experimental nuclear localization (PMID:12859192, PMID:24936070). |
| GO:0005640 nuclear outer membrane | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA (Ensembl Compara from rat P37377) placing alpha-synuclein at the nuclear outer membrane. Reason: The specific nuclear outer membrane localization is an electronic transfer from the rat ortholog with no experimental support for this sub-compartment in human; nuclear localization is captured by GO:0005634. Over-annotated at this granularity. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: UniProtKB:P37377 SUPPORTS SOURCE BUT NOT TARGET Rat ortholog transfer to nuclear outer membrane; no sub-compartment evidence supports this granularity for alpha-synuclein. |
| GO:0005737 cytoplasm | EXP PMID:19762560 Interaction with synphilin-1 promotes inclusion formation of... | ACCEPT | Summary: EXP cytoplasm localization (Falsone group and others). Reason: alpha-synuclein is an abundant soluble cytoplasmic/cytosolic protein; cytoplasmic localization is well established by multiple EXP/IDA rows. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | EXP PMID:24936070 The H50Q mutation enhances Ξ±-synuclein aggregation, secretio... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | EXP PMID:26442590 Dopamine Transporter Activity Is Modulated by Ξ±-Synuclein. | ACCEPT | Summary: EXP cytoplasm localization. Reason: Reinforces the well-supported cytoplasmic localization. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | EXP PMID:31034892 Increased Aggregation Tendency of Alpha-Synuclein in a Fully... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | EXP PMID:33657088 DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of Ξ±-synucle... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: IBA (PANTHER PTN000352385) is_active_in cytoplasm, with the gene's own experimental annotation among the seeds. Reason: The cytoplasmic/cytosolic location of alpha-synuclein where it acts as a soluble protein is phylogenetically conserved and experimentally grounded. The target appearing among WITH/FROM is expected, not circular. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000352385 SUPPORTS TRANSFER Synuclein ancestral node; soluble cytoplasmic localization is conserved and experimentally grounded in mouse/rat and human. |
| GO:0005737 cytoplasm | IDA PMID:12406186 Upregulation of alpha-synuclein by lipopolysaccharide and in... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IDA PMID:12958153 Modulation of dopamine transporter function by alpha-synucle... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IDA PMID:15863497 Proteolytic cleavage of extracellular secreted {alpha}-synuc... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IDA PMID:16959795 Alpha-synuclein acts in the nucleus to inhibit histone acety... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IDA PMID:17408955 alpha-Synuclein and its disease-related mutants interact dif... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IDA PMID:23983262 Polo-like kinase 2 regulates selective autophagic Ξ±-synuclei... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IDA PMID:24403142 Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IDA PMID:25561023 Molecular determinants of Ξ±-synuclein mutants' oligomerizati... | ACCEPT | Summary: One of many EXP/IDA rows placing alpha-synuclein in the cytoplasm. Reason: Cytoplasmic localization is a robustly supported core location of the soluble protein; these rows reinforce one claim. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: IEA (combined automated methods) cytoplasm, with the synuclein InterPro signature. Reason: Consistent with experimental cytoplasmic localization. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: InterPro:IPR002460 SUPPORTS TRANSFER Synuclein-alpha family signature; cytoplasmic localization is correct. |
| GO:0005739 mitochondrion | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA (Ensembl Compara from rat P37377) mitochondrion. Reason: Mitochondrial association of alpha-synuclein is reported mainly under pathological/overexpression conditions (binding complex I on the inner membrane). For a predominantly cytosolic/presynaptic protein, an electronic whole-organelle transfer from rat is better treated as over-annotation pending sub-compartment evidence in human. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: UniProtKB:P37377 SUPPORTS SOURCE BUT NOT TARGET Rat ortholog electronic transfer; mitochondrial association is largely a disease/overexpression phenomenon, not a constitutive location. |
| GO:0005739 mitochondrion | TAS PMID:24252804 The role of oxidative stress in Parkinson's disease. | MARK AS OVER ANNOTATED | Summary: TAS from an oxidative-stress review that describes alpha-synuclein binding the inner mitochondrial membrane and complex I. Reason: The review summarizes disease-context mitochondrial binding (complex I inhibition); this is not an established constitutive location of the normal protein. Over-annotation for the cellular-component claim. Supporting Evidence: PMID:24252804 PD causing gene products including DJ-1, PINK1, parkin, alpha-synuclein and LRRK2 also impact in complex ways mitochondrial function leading to exacerbation of ROS generation and susceptibility to oxidative stress. |
| GO:0005741 mitochondrial outer membrane | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA (Ensembl Compara from rat) mitochondrial outer membrane. Reason: Sub-organelle electronic transfer with no human experimental support; alpha-synuclein's reported mitochondrial contacts are mainly disease-associated and have been placed at the inner membrane/complex I. Over-annotated. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: UniProtKB:P37377 SUPPORTS SOURCE BUT NOT TARGET Rat ortholog transfer to the mitochondrial outer membrane; no sub-compartment evidence supports this for alpha-synuclein. |
| GO:0005743 mitochondrial inner membrane | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA (Ensembl Compara from rat) mitochondrial inner membrane. Reason: As for the outer-membrane row: a sub-organelle electronic transfer without human experimental grounding; disease-context only. Over-annotated. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: UniProtKB:P37377 SUPPORTS SOURCE BUT NOT TARGET Rat ortholog transfer; inner-membrane localization is a disease-context observation. |
| GO:0005759 mitochondrial matrix | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA (Ensembl Compara from rat) mitochondrial matrix. Reason: Matrix localization has no support for alpha-synuclein; an electronic transfer artifact at fine granularity. Over-annotated. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: UniProtKB:P37377 SUPPORTS SOURCE BUT NOT TARGET Rat ortholog transfer to matrix; no evidence places alpha-synuclein in the mitochondrial matrix. |
| GO:0005764 lysosome | TAS PMID:24477431 Reduced glucocerebrosidase is associated with increased Ξ±-sy... | KEEP AS NON CORE | Summary: Murphy et al. (TAS): GBA deficiency raises alpha-synuclein via reduced lysosomal chaperone-mediated autophagy. Reason: alpha-synuclein is a substrate degraded in lysosomes (CMA), so a lysosomal pool exists in the degradative context. Non-core location. Supporting Evidence: PMID:24477431 The selective loss of lysosomal glucocerebrosidase was directly related to reduced lysosomal chaperone-mediated autophagy, increased Ξ±-synuclein and decreased ceramide. |
| GO:0005829 cytosol | IDA PMID:24936070 The H50Q mutation enhances Ξ±-synuclein aggregation, secretio... | ACCEPT | Summary: Khalaf et al.: IDA cytosol. Reason: Cytosolic localization of the soluble protein is a core location. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005829 cytosol | IDA PMID:31034892 Increased Aggregation Tendency of Alpha-Synuclein in a Fully... | ACCEPT | Summary: Falsone group: IDA cytosol. Reason: Reinforces cytosolic localization. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005829 cytosol | IDA PMID:8248242 Molecular cloning of cDNA encoding an unrecognized component... | ACCEPT | Summary: Ueda et al. (NACP cloning): NACP detected in the cytosolic fraction of brain homogenates. Reason: Original identification of the protein in the brain cytosolic fraction; core location. Supporting Evidence: PMID:8248242 NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5658104 | ACCEPT | Summary: Reactome TAS cytosol (alpha-synuclein ubiquitination / processing reactions). Reason: Reactome places the soluble protein in the cytosol for its ubiquitination and turnover reactions, consistent with the experimental cytosolic localization. Supporting Evidence: Reactome:R-HSA-5658104 SNCAIP |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5658496 | ACCEPT | Summary: Reactome TAS cytosol (alpha-synuclein ubiquitination / processing reactions). Reason: Reactome places the soluble protein in the cytosol for its ubiquitination and turnover reactions, consistent with the experimental cytosolic localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5660752 | ACCEPT | Summary: Reactome TAS cytosol (alpha-synuclein ubiquitination / processing reactions). Reason: Reactome places the soluble protein in the cytosol for its ubiquitination and turnover reactions, consistent with the experimental cytosolic localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5660753 | ACCEPT | Summary: Reactome TAS cytosol (alpha-synuclein ubiquitination / processing reactions). Reason: Reactome places the soluble protein in the cytosol for its ubiquitination and turnover reactions, consistent with the experimental cytosolic localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5660757 | ACCEPT | Summary: Reactome TAS cytosol (alpha-synuclein ubiquitination / processing reactions). Reason: Reactome places the soluble protein in the cytosol for its ubiquitination and turnover reactions, consistent with the experimental cytosolic localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5661157 | ACCEPT | Summary: Reactome TAS cytosol (alpha-synuclein ubiquitination / processing reactions). Reason: Reactome places the soluble protein in the cytosol for its ubiquitination and turnover reactions, consistent with the experimental cytosolic localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5661161 | ACCEPT | Summary: Reactome TAS cytosol (alpha-synuclein ubiquitination / processing reactions). Reason: Reactome places the soluble protein in the cytosol for its ubiquitination and turnover reactions, consistent with the experimental cytosolic localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9836435 | ACCEPT | Summary: Reactome TAS cytosol (alpha-synuclein ubiquitination / processing reactions). Reason: Reactome places the soluble protein in the cytosol for its ubiquitination and turnover reactions, consistent with the experimental cytosolic localization. |
| GO:0005840 ribosome | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Ribosome (IEA), from an annotation citing an immunolocalization study of alpha-synuclein in Schwann cells (PMID:11810180); alpha-synuclein is not a ribosomal component. Reason: The row is transferred from an ortholog annotation recorded as a direct assay from a study of alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells (PMID:11810180), so an immunolocalization observation lies behind it; only the abstract is available. Immunoreactivity near ribosomes does not make alpha-synuclein a component of the ribosome, and no biochemical study shows it as one. The term over-reads a localization result; the observation is not refuted, so the row is marked as an over-annotation rather than removed. Propagation Review Root cause: PROPAGATION BAD Failure modes: COMPARTMENT OR COMPLEX MISMATCH Sources checked: UniProtKB:P37377 SOURCE BAD Rat ortholog electronic transfer to ribosome; no experimental basis. alpha-synuclein is not a ribosomal protein. Supporting Evidence: PMID:33657088 We discovered that Ξ±-synuclein interacts with Dbp4 or its human ortholog DDX10, sequesters the protein outside the nucleolus in yeast and in human cells |
| GO:0005886 plasma membrane | IDA PMID:12958153 Modulation of dopamine transporter function by alpha-synucle... | ACCEPT | Summary: Wersinger et al.: IDA plasma-membrane localization (DAT co-expression). Reason: Membrane-bound alpha-synuclein associates with the plasma membrane via its amphipathic helix; a genuine functional location for the SNARE-chaperone and transporter-modulating roles. Supporting Evidence: PMID:26442590 the majority of DATΒ·Ξ±-synuclein protein complexes are found at the plasma membrane of dopaminergic neurons or mammalian cells |
| GO:0005886 plasma membrane | IDA PMID:15641770 Fluorescence studies suggest a role for alpha-synuclein in t... | ACCEPT | Summary: Narayanan et al.: IDA; PI(4,5)P2/Ca2+-enhanced plasma-membrane association. Reason: Supports plasma-membrane association. Supporting Evidence: PMID:15641770 the membrane association of alpha-synuclein is enhanced by the presence of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] and Ca(2+) |
| GO:0005886 plasma membrane | IDA PMID:17222866 Relationships between the sequence of alpha-synuclein and it... | ACCEPT | Summary: Volles and Lansbury: IDA membrane/plasma-membrane binding. Reason: Supports plasma-membrane/membrane localization via the amphipathic helix. Supporting Evidence: PMID:17222866 Most of these contained a mutation to either proline or glutamic acid that caused a defect in membrane binding. |
| GO:0005938 cell cortex | IDA PMID:19157893 Fluorescence microscopy and 3D image reconstruction of cytok... | KEEP AS NON CORE | Summary: Dihanich group (IFN study): alpha-synuclein at the tips of cellular processes / cell cortex in glioblastoma cells. Reason: Cortical/process-tip localization is reported in a cytokine-stimulation cell study; peripheral and context-specific. Non-core. Supporting Evidence: PMID:19157893 alpha-synuclein occupying the tips of cellular processes |
| GO:0006749 glutathione metabolic process | IDA PMID:23507046 Ξ±-Synuclein-mediated defense against oxidative stress via mo... | KEEP AS NON CORE | Summary: Koo et al.: alpha-synuclein stimulates GPX-1 activity; glutathione metabolic process acts_upstream_of_positive_effect. Reason: Based on a single report that alpha-synuclein stimulates GPX-1; an indirect/non-core effect on glutathione metabolism. Supporting Evidence: PMID:23507046 Ξ±-synuclein enhanced the GPX-1 activity with Kd of 17.3nM and the enzyme in turn markedly enhanced in vitro fibrillation of Ξ±-synuclein |
| GO:0008017 microtubule binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (Ensembl Compara from rat) microtubule binding. Reason: Microtubule binding is shown directly for alpha-synuclein (PMID:27628239). GO:0008017 is a child of GO:0015631 tubulin binding, so this is the more specific of the two terms. The core function keeps the parent, tubulin binding, because the protein also binds the free tubulin alpha2beta2 tetramer. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog transfer; microtubule binding is directly supported for human alpha-synuclein. Supporting Evidence: PMID:27628239 We demonstrated that Ξ±-Synuclein binds to microtubules and tubulin Ξ±2Ξ²2 tetramer |
| GO:0008021 synaptic vesicle | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (Ensembl Compara from rat) synaptic vesicle. Reason: alpha-synuclein associates with synaptic vesicle membranes at the presynapse; a correct location. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; synaptic-vesicle association is conserved and experimentally established. |
| GO:0008047 enzyme activator activity | IDA PMID:23507046 Ξ±-Synuclein-mediated defense against oxidative stress via mo... | KEEP AS NON CORE | Summary: Koo et al.: alpha-synuclein enhances GPX-1 enzyme activity (Kd 17.3 nM). Reason: Single-report enzyme-activator activity toward GPX-1; peripheral to core function. Supporting Evidence: PMID:23507046 Ξ±-synuclein enhanced the GPX-1 activity with Kd of 17.3nM and the enzyme in turn markedly enhanced in vitro fibrillation of Ξ±-synuclein |
| GO:0008198 ferrous iron binding | IDA PMID:11850416 Magnesium inhibits spontaneous and iron-induced aggregation ... | KEEP AS NON CORE | Summary: Golts et al.: ferrous iron interacts with alpha-synuclein (tyrosine fluorescence) and promotes aggregation. Reason: Fe(II) binding inferred indirectly; relevant to metal-promoted aggregation rather than a physiological function. Non-core. Supporting Evidence: PMID:11850416 we show that iron and magnesium both interact with alpha-synuclein |
| GO:0008270 zinc ion binding | IDA PMID:11850416 Magnesium inhibits spontaneous and iron-induced aggregation ... | KEEP AS NON CORE | Summary: Golts et al.: zinc context in the same metal-aggregation study. Reason: Zinc binding is weakly supported here (the study centers on Fe/Mg). Non-core biochemical property. Supporting Evidence: PMID:11850416 we show that iron and magnesium both interact with alpha-synuclein |
| GO:0008289 lipid binding | EXP PMID:11286556 Conformational properties of alpha-synuclein in its free and... | ACCEPT | Summary: Eliezer et al.: EXP lipid binding; N-terminal region adopts helix on lipid vesicles/micelles. Reason: Lipid binding is a core molecular function; the amphipathic N-terminus binds lipid surfaces. Supporting Evidence: PMID:11286556 The N-terminal region of alphaS binds to synthetic lipid vesicles and detergent micelles in vitro and adopts a highly helical conformation |
| GO:0008289 lipid binding | EXP PMID:20524659 A combinatorial NMR and EPR approach for evaluating the stru... | ACCEPT | Summary: Bortolini/Jao et al.: EXP lipid binding (micelle-bound structural ensemble). Reason: Reinforces lipid binding. Supporting Evidence: PMID:20524659 A surprising variety of well-defined protein-micelle interactions was thus revealed in which the micelle is engulfed by two differently arranged antiparallel alphaS helices. |
| GO:0008289 lipid binding | EXP PMID:22315227 Ξ±-Synuclein in central nervous system and from erythrocytes,... | ACCEPT | Summary: Fauvet et al.: EXP; alpha-synuclein can become structured on membranes (lipid binding). Reason: Supports lipid binding in the membrane-bound state. Supporting Evidence: PMID:22315227 These results do not rule out the possibility that Ξ±-syn becomes structured upon interaction with other proteins and/or biological membranes. |
| GO:0010040 response to iron(II) ion | IDA PMID:11850416 Magnesium inhibits spontaneous and iron-induced aggregation ... | KEEP AS NON CORE | Summary: Golts et al.: response to iron(II); Fe promotes alpha-synuclein aggregation. Reason: Response to Fe(II) is an in vitro aggregation phenomenon, peripheral to physiological function. Supporting Evidence: PMID:11850416 These data suggest that the conformation of alpha-synuclein can be modulated by metals, with iron promoting aggregation and magnesium inhibiting aggregation. |
| GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway | IDA PMID:12239163 Evidence that alpha-synuclein functions as a negative regula... | MARK AS OVER ANNOTATED | Summary: Park et al.: alpha-synuclein inhibits Ca2+-dependent alpha-granule release in platelets; annotated as negative regulation of PDGF receptor signaling. Reason: The paper measures alpha-granule secretion (also inhibited by ionomycin), i.e. a late secretory step, not PDGF-receptor signal transduction. The PDGF-receptor-signaling term is a mis-chosen process. Supporting Evidence: PMID:12239163 ionomycin- or thrombin-induced alpha-granule secretion was inhibited by exogenous alpha-synuclein addition in a dose-dependent manner PMID:12239163 alpha-synuclein may function as a specific negative regulator of alpha-granule release in platelets |
| GO:0014059 regulation of dopamine secretion | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: IEA (GO_REF:0000002, InterPro IPR002460) regulation of dopamine secretion. Reason: alpha-synuclein modulates dopamine release/secretion (knockout and transporter data); the family-signature electronic row is consistent though broad. Non-core process. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: InterPro:IPR002460 SUPPORTS TRANSFER Synuclein-alpha signature; dopamine-secretion regulation is supported experimentally. |
| GO:0014059 regulation of dopamine secretion | TAS PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | KEEP AS NON CORE | Summary: TAS (Meloni and Vasak) regulation of dopamine secretion. Reason: The cited bioinorganic paper does not directly assay dopamine secretion, but dopamine-release modulation is supported elsewhere; keep the process as non-core and flag the citation. Supporting Evidence: PMID:10707987 alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission |
| GO:0015629 actin cytoskeleton | IDA PMID:17408955 alpha-Synuclein and its disease-related mutants interact dif... | KEEP AS NON CORE | Summary: Esposito et al.: IDA; alpha-synuclein associates with the actin cytoskeleton. Reason: Actin-cytoskeleton association is reported but peripheral and possibly indirect. Non-core. Supporting Evidence: PMID:17408955 alpha-synuclein associates with the actin cytoskeleton and interacts with tau |
| GO:0015631 tubulin binding | EXP PMID:27628239 Ξ±-Synuclein is a Novel Microtubule Dynamase. | ACCEPT | Summary: Cartelli et al.: EXP; alpha-synuclein binds microtubules and the tubulin alpha2beta2 tetramer. Reason: Direct tubulin binding is experimentally established and underlies the microtubule-dynamase activity. Accept as a genuine molecular function. Supporting Evidence: PMID:27628239 We demonstrated that Ξ±-Synuclein binds to microtubules and tubulin Ξ±2Ξ²2 tetramer |
| GO:0016020 membrane | IDA PMID:24936070 The H50Q mutation enhances Ξ±-synuclein aggregation, secretio... | TOO GENERAL | Summary: Khalaf et al.: IDA membrane localization. Reason: True but uninformative. The review asserts the more specific plasma membrane (GO:0005886) and synaptic vesicle membrane (GO:0030672), both descendants of membrane. Supporting Evidence: PMID:11286556 The N-terminal region of alphaS binds to synthetic lipid vesicles and detergent micelles in vitro and adopts a highly helical conformation |
| GO:0016020 membrane | IEA GO_REF:0000044 | TOO GENERAL | Summary: IEA (UniProt SL-0162 Membrane) membrane localization. Reason: True but uninformative. The UniProt Membrane keyword is entailed by the asserted plasma membrane (GO:0005886) and synaptic vesicle membrane (GO:0030672) rows. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: UniProtKB-SubCell:SL-0162 SUPPORTS TRANSFER UniProt Membrane keyword; membrane association is established, this generic term is subsumed by plasma-membrane / synaptic-vesicle-membrane rows. |
| GO:0016079 synaptic vesicle exocytosis | IDA PMID:28288128 Ξ±-Synuclein promotes dilation of the exocytotic fusion pore. | ACCEPT | Summary: Logan et al.: alpha-synuclein accelerates exocytotic fusion-pore dilation (endogenous and overexpressed). Reason: Direct demonstration that alpha-synuclein modulates synaptic/dense-core vesicle exocytosis (fusion-pore dilation); a core physiological process. Supporting Evidence: PMID:28288128 both overexpressed and endogenous synuclein accelerate the kinetics of individual exocytotic events, promoting cargo discharge and reducing pore closure |
| GO:0016082 synaptic vesicle priming | IBA GO_REF:0000033 | ACCEPT | Summary: IBA (PANTHER PTN008551824) synaptic vesicle priming, with the gene's own experimental annotation among seeds. Reason: Supported by IMP (PMID:30404828) showing alpha-synuclein involvement in vesicle priming and fusion; the phylogenetic node placement is sound. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN008551824 SUPPORTS TRANSFER Synuclein node; vesicle priming is experimentally grounded (PMID:30404828) and conserved. |
| GO:0016082 synaptic vesicle priming | IMP PMID:30404828 Soluble Ξ±-synuclein facilitates priming and fusion by releas... | ACCEPT | Summary: Liu et al.: IMP; soluble alpha-synuclein is involved in vesicle priming and fusion in PC12 cells. Reason: Direct functional evidence for a role in synaptic vesicle priming; core process. Supporting Evidence: PMID:30404828 Our results show that Ξ±-synuclein is involved in vesicle priming and fusion. PMID:30404828 overexpressed Ξ±-synuclein in PC12 cells was found to be in a monomeric form, which promotes exocytosis |
| GO:0016234 inclusion body | IDA PMID:17222866 Relationships between the sequence of alpha-synuclein and it... | KEEP AS NON CORE | Summary: Volles and Lansbury: IDA inclusion body (aggregated alpha-synuclein). Reason: Inclusion-body localization is a disease/aggregation state; non-core. Supporting Evidence: PMID:17222866 Most of these contained a mutation to either proline or glutamic acid that caused a defect in membrane binding. |
| GO:0016234 inclusion body | IDA PMID:20039155 Association of metallothionein-III with oligodendroglial cyt... | KEEP AS NON CORE | Summary: Pountney group: IDA; alpha-synuclein in glial cytoplasmic inclusion bodies (MSA). Reason: Inclusion-body localization in disease; non-core. Supporting Evidence: PMID:20039155 Immunofluorescence double labelling showed the co-localisation of alpha-synuclein and MT-III in GCIs in MSA tissue. |
| GO:0016234 inclusion body | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA (ARBA) inclusion body. Reason: Electronic ARBA row for inclusion-body localization; consistent with the disease aggregation state. Non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: ARBA:ARBA00086956 SUPPORTS TRANSFER ARBA rule; inclusion-body localization matches experimental Lewy-body/GCI data. |
| GO:0016491 oxidoreductase activity | IDA PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | MARK AS OVER ANNOTATED | Summary: Meloni and Vasak: the alpha-Syn-Cu(II) complex has oxidase activity in vitro; annotated as oxidoreductase activity. Reason: The catalytic oxidase activity is a property of the alpha-synuclein-copper complex under aerobic conditions and generates ROS; it reflects aberrant metal-centred redox chemistry, not an intrinsic enzymatic function of the apo-protein. Over-annotation of a molecular function. Supporting Evidence: PMID:21320589 under aerobic conditions Ξ±-Syn-Cu(II) possesses catalytic oxidase activity |
| GO:0019894 kinesin binding | IPI PMID:16176937 Molecular motors implicated in the axonal transport of tau a... | UNDECIDED | Summary: Utton et al.: kinesin binding (IPI); the paper carries a 2024 expression of concern. Reason: The kinesin co-immunoprecipitation underlying this row is from a paper now under an expression of concern, so the evidence cannot be relied upon. Mark UNDECIDED pending re-evaluation. Supporting Evidence: PMID:16176937 Co-immunoprecipitation experiments demonstrate that tau and alpha-synuclein are each associated with complexes containing kinesin-1, whereas only alpha-synuclein appears to interact with dynein-containing complexes. PMID:16176937 Expression of concern in |
| GO:0019899 enzyme binding | IEA GO_REF:0000107 | TOO GENERAL | Summary: IEA (Ensembl Compara from rat) enzyme binding. Reason: True but uninformative. The review asserts the more specific phospholipase binding (GO:0043274), a descendant of enzyme binding. Electronic transfer from the rat ortholog. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog electronic transfer to generic enzyme binding; true, and entailed by phospholipase binding. |
| GO:0019899 enzyme binding | IPI PMID:23507046 Ξ±-Synuclein-mediated defense against oxidative stress via mo... | TOO GENERAL | Summary: Koo et al.: IPI enzyme binding (GPX-1). Reason: Binding to the enzyme GPX-1 is reported (abstract only). The term is true but uninformative. The review asserts the more specific phospholipase binding (GO:0043274), a descendant of enzyme binding, and the GPX-1 relationship is captured by the enzyme activator activity row (PMID:23507046). Supporting Evidence: PMID:23507046 Ξ±-synuclein enhanced the GPX-1 activity with Kd of 17.3nM and the enzyme in turn markedly enhanced in vitro fibrillation of Ξ±-synuclein |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000107 | UNDECIDED | Summary: IEA (Ensembl Compara from rat) protein domain specific binding. Reason: No specific domain-binding term is asserted in this review, so the generic term is not entailed by a more specific one, and the rat ortholog's source row was not inspected to see which domain interaction it records. Left undecided rather than called over-annotated. Propagation Review Root cause: UNRESOLVED Sources checked: UniProtKB:P37377 UNRESOLVED Rat ortholog electronic transfer; the underlying domain interaction was not identified. |
| GO:0030424 axon | IDA PMID:12958153 Modulation of dopamine transporter function by alpha-synucle... | ACCEPT | Summary: Wersinger et al.: IDA axon localization. Reason: alpha-synuclein localizes to axons/presynaptic terminals; a correct location. Supporting Evidence: PMID:12958153 alpha-synuclein induced a 35% decrease in [3H]DA uptake |
| GO:0030424 axon | IEA GO_REF:0000044 | ACCEPT | Summary: IEA (UniProt SL-0279) axon. Reason: Consistent with axonal localization. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB-SubCell:SL-0279 SUPPORTS TRANSFER UniProt axon keyword; consistent with presynaptic/axonal localization. |
| GO:0030426 growth cone | IDA PMID:12958153 Modulation of dopamine transporter function by alpha-synucle... | KEEP AS NON CORE | Summary: Wersinger et al.: IDA growth cone. Reason: Growth-cone localization reported; peripheral. Non-core. Supporting Evidence: PMID:12958153 alpha-synuclein induced a 35% decrease in [3H]DA uptake |
| GO:0030426 growth cone | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) growth cone. Reason: Consistent with the growth-cone row; non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; growth-cone localization is a minor peripheral location. |
| GO:0030544 Hsp70 protein binding | IPI PMID:18975920 Interactions between Hsp70 and the hydrophobic core of alpha... | ACCEPT | Summary: Luk et al.: IPI; Hsp70 substrate-binding domain interacts with the alpha-synuclein core hydrophobic region. Reason: Direct Hsp70 binding is experimentally established and relevant to chaperone-mediated handling of alpha-synuclein. Accept this specific binding term. Supporting Evidence: PMID:18975920 interactions between the Hsp70 substrate binding domain and the alpha-Syn core hydrophobic region underlie assembly inhibition |
| GO:0030544 Hsp70 protein binding | IPI PMID:18975920 Interactions between Hsp70 and the hydrophobic core of alpha... | ACCEPT | Summary: Luk et al.: IPI Hsp70 binding (duplicate row). Reason: Duplicate of the Hsp70-binding claim; reinforces it. Supporting Evidence: PMID:18975920 interactions between the Hsp70 substrate binding domain and the alpha-Syn core hydrophobic region underlie assembly inhibition |
| GO:0030659 cytoplasmic vesicle membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) cytoplasmic vesicle membrane. Reason: Consistent with vesicle-membrane association. Kept as non-core because the core location is the synaptic vesicle membrane, a more specific vesicle membrane carried on its own rows. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; cytoplasmic-vesicle-membrane association is correct but generic. |
| GO:0030672 synaptic vesicle membrane | IBA GO_REF:0000033 | ACCEPT | Summary: IBA (PANTHER PTN009013518) is_active_in synaptic vesicle membrane. Reason: alpha-synuclein acts on synaptic vesicle membranes at the presynapse; the phylogenetic placement with the mouse experimental donor is sound. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN009013518 SUPPORTS TRANSFER Synuclein node; synaptic-vesicle-membrane activity is the conserved presynaptic function. |
| GO:0031092 platelet alpha granule membrane | IDA PMID:12239163 Evidence that alpha-synuclein functions as a negative regula... | KEEP AS NON CORE | Summary: Park et al.: colocalizes_with platelet alpha-granule membrane. Reason: In platelets alpha-synuclein is loosely associated with alpha-granule membranes; a genuine but peripheral, tissue-specific location (colocalizes_with qualifier). Non-core. Supporting Evidence: PMID:12239163 loosely associated with the membrane of the secretory alpha-granules |
| GO:0031115 negative regulation of microtubule polymerization | IDA PMID:21127069 Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydro... | KEEP AS NON CORE | Summary: Qureshi and Paudel: IDA; alpha-synuclein (with tau) destabilizes microtubules. Reason: Negative regulation of microtubule polymerization is shown in vitro/cell models and overlaps the microtubule-dynamase activity (which includes increased catastrophe). A real but context-dependent effect; non-core. Supporting Evidence: PMID:21127069 Ξ±-synuclein and its all PD-associated mutants destabilize the microtubule cytoskeleton in a similar extent |
| GO:0031623 receptor internalization | IDA PMID:18980610 Alpha-synuclein and polyunsaturated fatty acids promote clat... | ACCEPT | Summary: Ben Gedalya et al.: IDA; alpha-synuclein+PUFA enhances clathrin-mediated endocytosis / receptor internalization. Reason: Enhanced internalization (transferrin, FM1-43) in a clathrin-dependent manner is directly shown; relevant to synaptic-vesicle recycling. Accept the receptor-internalization process. Supporting Evidence: PMID:18980610 alphaS expression coupled with exposure to physiological levels of certain PUFAs enhanced clathrin-mediated endocytosis in neuronal and non-neuronal cultured cells |
| GO:0031648 protein destabilization | IDA PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | KEEP AS NON CORE | Summary: Meloni and Vasak: protein destabilization (alpha-Syn-Cu redox promotes oxidation/oligomerization). Reason: Refers to copper-redox-driven oxidation/destabilization of alpha-synuclein itself; a disease-context effect. Non-core. Supporting Evidence: PMID:21320589 The observed metal-centered redox chemistry significantly promotes the production of hydroxyl radicals and Ξ±-Syn oxidation and oligomerization |
| GO:0032026 response to magnesium ion | IDA PMID:11850416 Magnesium inhibits spontaneous and iron-induced aggregation ... | KEEP AS NON CORE | Summary: Golts et al.: response to magnesium ion (Mg2+ inhibits aggregation). Reason: An in vitro metal-response phenomenon; peripheral. Non-core. Supporting Evidence: PMID:11850416 These data suggest that the conformation of alpha-synuclein can be modulated by metals, with iron promoting aggregation and magnesium inhibiting aggregation. |
| GO:0032496 response to lipopolysaccharide | IDA PMID:12406186 Upregulation of alpha-synuclein by lipopolysaccharide and in... | KEEP AS NON CORE | Summary: Tanji et al.: IDA; LPS and IL-1beta upregulate alpha-synuclein in macrophages. Reason: Response to LPS is an expression change in macrophages, indicating inflammatory regulation of the gene rather than a presynaptic function. Non-core. Supporting Evidence: PMID:12406186 levels of alpha-synuclein protein were increased by stimulation with lipopolysaccharide and interleukin-1beta |
| GO:0032991 protein-containing complex | IMP PMID:31034892 Increased Aggregation Tendency of Alpha-Synuclein in a Fully... | ACCEPT | Summary: Falsone group: IMP; alpha-synuclein forms a protein-containing complex (with SERF1a). Reason: alpha-synuclein participates in defined protein complexes (SNARE-associated, SERF1a, homomultimers); the generic protein-containing-complex part_of is correct. Supporting Evidence: PMID:31034892 This minimal exposure was sufficient to increase the amyloidogenic tendency of SERF1a-bound aSyn. |
| GO:0034341 response to type II interferon | IDA PMID:19157893 Fluorescence microscopy and 3D image reconstruction of cytok... | KEEP AS NON CORE | Summary: Dihanich group: IDA; IFN-gamma alters peripheral alpha-synuclein distribution in glioblastoma cells. Reason: Response to type II interferon is a cytokine-induced redistribution in a non-neuronal cell model; peripheral. Non-core. Supporting Evidence: PMID:19157893 IFN caused a disruption and reduction of peripheral synuclein |
| GO:0034599 cellular response to oxidative stress | IDA PMID:23507046 Ξ±-Synuclein-mediated defense against oxidative stress via mo... | KEEP AS NON CORE | Summary: Koo et al.: IDA; alpha-synuclein modulation of GPX-1 as a defence against oxidative stress. Reason: Cellular response to oxidative stress via GPX-1 modulation from a single report; peripheral to core function. Supporting Evidence: PMID:23507046 The entrapped enzyme was demonstrated to be protected in a latent form and its activity was fully recovered as released from the matrix. |
| GO:0035493 SNARE complex assembly | IDA PMID:20798282 Alpha-synuclein promotes SNARE-complex assembly in vivo and ... | ACCEPT | Summary: Burre et al.: IDA; alpha-synuclein promotes SNARE-complex assembly. Reason: Direct demonstration that alpha-synuclein drives SNARE-complex assembly (via VAMP2 binding); this is the core chaperone process. Supporting Evidence: PMID:20798282 Ξ±-synuclein directly bound to the SNARE-protein synaptobrevin-2/vesicle-associated membrane protein 2 (VAMP2) and promoted SNARE-complex assembly PMID:20798282 triple-knockout mice lacking synucleins developed age-dependent neurological impairments, exhibited decreased SNARE-complex assembly, and died prematurely |
| GO:0035543 positive regulation of SNARE complex assembly | IDA PMID:20798282 Alpha-synuclein promotes SNARE-complex assembly in vivo and ... | ACCEPT | Summary: Burre et al.: IDA positive regulation of SNARE-complex assembly. Reason: The positive-regulation framing of the same core SNARE-chaperone activity; accept. Supporting Evidence: PMID:20798282 Ξ±-synuclein directly bound to the SNARE-protein synaptobrevin-2/vesicle-associated membrane protein 2 (VAMP2) and promoted SNARE-complex assembly |
| GO:0042220 response to cocaine | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) response to cocaine. Reason: A pharmacological/behavioural response term transferred electronically from rat; peripheral to molecular function. Non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; response-to-cocaine reflects dopaminergic-system involvement, peripheral. |
| GO:0042393 histone binding | IDA PMID:16959795 Alpha-synuclein acts in the nucleus to inhibit histone acety... | ACCEPT | Summary: Kontopoulos et al.: IDA; alpha-synuclein binds directly to histones. Reason: Direct histone binding is shown (and inhibits histone acetylation in the nuclear pool). Accept this specific binding term. Supporting Evidence: PMID:16959795 Alpha-synuclein binds directly to histones, reduces the level of acetylated histone H3 in cultured cells |
| GO:0042416 dopamine biosynthetic process | TAS PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | MARK AS OVER ANNOTATED | Summary: TAS (Meloni and Vasak) dopamine biosynthetic process. Reason: The cited paper is a bioinorganic study of the alpha-Syn-Cu complex and does not assay dopamine biosynthesis. alpha-synuclein inhibits tyrosine hydroxylase (PMID:11943812) rather than performing a biosynthetic step, so the 'biosynthetic process' involvement is a mis-chosen/over-reaching term. Supporting Evidence: PMID:11943812 observed a dose-dependent inhibition of tyrosine hydroxylase by alpha-synuclein |
| GO:0042802 identical protein binding | IDA PMID:24936070 The H50Q mutation enhances Ξ±-synuclein aggregation, secretio... | ACCEPT | Summary: IDA identical protein binding (self-oligomerization/homomultimerization). Reason: alpha-synuclein self-associates (homotetramer and higher oligomers on membranes; amyloid self-assembly). Self-association is a genuine, well-supported molecular property. Supporting Evidence: PMID:25246573 Ξ±-synuclein multimerizes into large homomeric complexes upon membrane binding |
| GO:0042802 identical protein binding | IDA PMID:25561023 Molecular determinants of Ξ±-synuclein mutants' oligomerizati... | ACCEPT | Summary: IDA identical protein binding (self-oligomerization/homomultimerization). Reason: alpha-synuclein self-associates (homotetramer and higher oligomers on membranes; amyloid self-assembly). Self-association is a genuine, well-supported molecular property. Supporting Evidence: PMID:25561023 We identified the key amino acids that can interact with the membrane |
| GO:0042802 identical protein binding | IPI PMID:15502874 DJ-1 is a redox-dependent molecular chaperone that inhibits ... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:15502874 DJ-1 chaperone activity in vivo extends to alpha-synuclein, a protein implicated in PD pathogenesis |
| GO:0042802 identical protein binding | IPI PMID:16330551 Dequalinium-induced protofibril formation of alpha-synuclein... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:16330551 protofibril formation |
| GO:0042802 identical protein binding | IPI PMID:16764865 Acceleration of alpha-synuclein aggregation by homologous pe... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:16764865 Acceleration of alpha-synuclein aggregation by homologous peptides |
| GO:0042802 identical protein binding | IPI PMID:18614564 Proteomics analysis identifies phosphorylation-dependent alp... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:18614564 phosphorylation-dependent alpha-synuclein |
| GO:0042802 identical protein binding | IPI PMID:19745811 Pre-fibrillar alpha-synuclein variants with impaired beta-st... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:19745811 form increased amounts of soluble oligomers |
| GO:0042802 identical protein binding | IPI PMID:19875982 Chaperone proteostasis in Parkinson's disease: stabilization... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:19875982 a nucleotide-dependent interaction between Hsp70 and alphaSyn |
| GO:0042802 identical protein binding | IPI PMID:21358815 Ubiquitinylation of Ξ±-synuclein by carboxyl terminus Hsp70-i... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:21358815 Ξ±-syn can self associate into soluble oligomeric species |
| GO:0042802 identical protein binding | IPI PMID:21443877 Inhibition and disaggregation of Ξ±-synuclein oligomers by na... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:21443877 disaggregation of Ξ±-synuclein oligomers |
| GO:0042802 identical protein binding | IPI PMID:22119730 Ξ±-Synuclein modifies huntingtin aggregation in living cells. | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:22119730 Ξ±-Synuclein modifies huntingtin aggregation |
| GO:0042802 identical protein binding | IPI PMID:22854022 SERF protein is a direct modifier of amyloid fiber assembly. | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:22854022 a massive increase of soluble aSyn amyloid nucleation templates |
| GO:0042802 identical protein binding | IPI PMID:23927048 Ξ±-Synuclein as an intrinsically disordered monomer--fact or ... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:23927048 intrinsically disordered monomer |
| GO:0042802 identical protein binding | IPI PMID:24374342 The N-terminus of Ξ±-synuclein is essential for both monomeri... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:24374342 both monomeric and oligomeric |
| GO:0042802 identical protein binding | IPI PMID:24895406 The chaperone-like protein 14-3-3Ξ· interacts with human Ξ±-sy... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:24895406 interacts with human Ξ±-synuclein |
| GO:0042802 identical protein binding | IPI PMID:24983211 Ξ±-Synuclein interacts with the switch region of Rab8a in a S... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:24983211 interacts with the switch region of Rab8a |
| GO:0042802 identical protein binding | IPI PMID:25643172 Lipid vesicles trigger Ξ±-synuclein aggregation by stimulatin... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:25643172 the rate of primary nucleation can be enhanced by three orders of magnitude |
| GO:0042802 identical protein binding | IPI PMID:25732184 Direct visualization of alpha-synuclein oligomers reveals pr... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:25732184 the alpha-synuclein proximity ligation assay, which specifically recognizes alpha-synuclein oligomers |
| GO:0042802 identical protein binding | IPI PMID:31270237 Ξ±-synuclein-lipoprotein interactions and elevated ApoE level... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:31270237 numerous proteins interact with Ξ±SN species, influencing its toxicity in the brain |
| GO:0042802 identical protein binding | IPI PMID:32461689 Structures of Ξ±-synuclein filaments from multiple system atr... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:32461689 Structures of Ξ±-synuclein filaments from multiple system atrophy |
| GO:0042802 identical protein binding | IPI PMID:34860005 Interactions between SARS-CoV-2 N-Protein and Ξ±-Synuclein Ac... | ACCEPT | Summary: IPI identical protein binding (alpha-synuclein self-interaction / oligomerization). Reason: One of many rows documenting alpha-synuclein self-association from co-aggregation, oligomerization and interaction assays; these reinforce the self-association claim. Supporting Evidence: PMID:34860005 We observe the formation of multiprotein complexes and eventually amyloid fibrils |
| GO:0043014 alpha-tubulin binding | IPI PMID:11698390 Tubulin seeds alpha-synuclein fibril formation. | ACCEPT | Summary: Alim et al.: IPI alpha-tubulin binding; tubulin is an alpha-synuclein binding partner that seeds fibrils. Reason: Direct tubulin binding; underlies the microtubule-dynamase activity. Accept. Supporting Evidence: PMID:11698390 identified tubulin as an alpha-synuclein binding/associated protein |
| GO:0043025 neuronal cell body | IBA GO_REF:0000033 | ACCEPT | Summary: IBA (PANTHER PTN000352385) is_active_in neuronal cell body. Reason: alpha-synuclein is active in neuronal cell bodies and terminals; conserved neuronal localization. Sound node placement. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000352385 SUPPORTS TRANSFER Synuclein node; neuronal cell body localization is conserved. |
| GO:0043025 neuronal cell body | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (Ensembl Compara from rat) neuronal cell body. Reason: Consistent with neuronal cell-body localization. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; neuronal cell body localization is correct. |
| GO:0043065 positive regulation of apoptotic process | TAS PMID:24252804 The role of oxidative stress in Parkinson's disease. | MARK AS OVER ANNOTATED | Summary: TAS (oxidative-stress review) positive regulation of apoptotic process. Reason: Pro-apoptotic effects are a disease-context consequence of alpha-synuclein aggregation/mitochondrial stress summarized in a review, not a dedicated physiological function. Over-annotation; note this also opposes the experimental anti-apoptotic IMP row, which is context-dependent. Supporting Evidence: PMID:24252804 PD causing gene products including DJ-1, PINK1, parkin, alpha-synuclein and LRRK2 also impact in complex ways mitochondrial function leading to exacerbation of ROS generation and susceptibility to oxidative stress. |
| GO:0043066 negative regulation of apoptotic process | IMP PMID:10818098 Wild-type but not Parkinson's disease-related ala-53 --> Thr... | KEEP AS NON CORE | Summary: da Costa et al.: IMP; wild-type alpha-synuclein protects neurons from apoptotic stimuli. Reason: An anti-apoptotic effect of overexpressed wild-type protein is shown by reduced caspase activation; a context-dependent cytoprotective effect, non-core. (Opposite-sign to the review-based pro-apoptotic TAS row, reflecting genuinely different contexts.) Supporting Evidence: PMID:10818098 wild-type alpha-synuclein exerts an antiapoptotic effect in neurons |
| GO:0043195 terminal bouton | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (Ensembl Compara from rat) terminal bouton. Reason: Presynaptic terminal (bouton) localization is consistent with the established presynaptic function. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; terminal-bouton localization matches the presynaptic role. |
| GO:0043274 phospholipase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) phospholipase binding. Reason: alpha-synuclein has been reported to interact with phospholipases (PLD, PLCbeta2), though PLD inhibition was not reproduced (PMID:19146388). The binding term is plausible but peripheral and poorly resolved. Non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; phospholipase interaction reported but of uncertain physiological weight. Supporting Evidence: PMID:15641770 Binding of alpha-synuclein to PLCbeta(2) reduces its catalytic activity by 50%, but causes its level of activation by Gbetagamma subunits to increase from 4- to 24-fold. |
| GO:0043524 negative regulation of neuron apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) negative regulation of neuron apoptotic process. Reason: Consistent with the experimental anti-apoptotic/cytoprotective IMP data; a context-dependent, non-core process. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; matches cytoprotective findings (PMID:10818098). |
| GO:0043679 axon terminus | IBA GO_REF:0000033 | ACCEPT | Summary: IBA (PANTHER PTN000352385) is_active_in axon terminus. Reason: alpha-synuclein acts at axon termini/presynaptic terminals; conserved and experimentally grounded. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000352385 SUPPORTS TRANSFER Synuclein node; axon-terminus activity is the conserved presynaptic localization. |
| GO:0043679 axon terminus | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (Ensembl Compara from rat) axon terminus. Reason: Consistent with axon-terminus localization. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; axon-terminus localization correct. |
| GO:0044344 cellular response to fibroblast growth factor stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) cellular response to fibroblast growth factor stimulus. Reason: A response-to-stimulus term transferred electronically; not a core molecular function and only weakly connected to alpha-synuclein biology. Non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; FGF-response term is peripheral. |
| GO:0045202 synapse | EXP PMID:15282274 Lipid rafts mediate the synaptic localization of alpha-synuc... | ACCEPT | Summary: Fortin et al.: EXP synapse localization (lipid-raft-mediated). Reason: Synaptic localization is a core location established experimentally (raft-dependent targeting to the nerve terminal). Supporting Evidence: PMID:15282274 alpha-synuclein localizes almost exclusively to the nerve terminal |
| GO:0045202 synapse | IEA GO_REF:0000044 | ACCEPT | Summary: IEA (UniProt SL-0258 Synapse) synapse. Reason: Consistent with experimental synaptic localization. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB-SubCell:SL-0258 SUPPORTS TRANSFER UniProt Synapse keyword; matches experimental synaptic localization. |
| GO:0045807 positive regulation of endocytosis | IDA PMID:18980610 Alpha-synuclein and polyunsaturated fatty acids promote clat... | ACCEPT | Summary: Ben Gedalya et al.: IDA positive regulation of endocytosis. Reason: alpha-synuclein+PUFA enhances clathrin-mediated endocytosis and SV recycling; a core process linked to the presynaptic role. Supporting Evidence: PMID:18980610 alphaS expression coupled with exposure to physiological levels of certain PUFAs enhanced clathrin-mediated endocytosis in neuronal and non-neuronal cultured cells PMID:18980610 We suggest that alphaS and PUFAs normally function in endocytic mechanisms and are specifically involved in SV recycling upon neuronal stimulation. |
| GO:0045920 negative regulation of exocytosis | IMP PMID:12239163 Evidence that alpha-synuclein functions as a negative regula... | KEEP AS NON CORE | Summary: Park et al.: IMP negative regulation of exocytosis (alpha-granule release in platelets). Reason: alpha-synuclein inhibits Ca2+-dependent alpha-granule exocytosis in platelets; a genuine regulatory effect, though in a non-neuronal secretory context. Non-core. Supporting Evidence: PMID:12239163 ionomycin- or thrombin-induced alpha-granule secretion was inhibited by exogenous alpha-synuclein addition in a dose-dependent manner |
| GO:0045921 positive regulation of exocytosis | IMP PMID:30404828 Soluble Ξ±-synuclein facilitates priming and fusion by releas... | ACCEPT | Summary: Liu et al.: IMP positive regulation of exocytosis (vesicle priming/fusion in PC12 cells). Reason: Soluble monomeric alpha-synuclein promotes exocytosis by enhancing priming and fusion; a core process. Supporting Evidence: PMID:30404828 overexpressed Ξ±-synuclein in PC12 cells was found to be in a monomeric form, which promotes exocytosis |
| GO:0045963 negative regulation of dopamine metabolic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) negative regulation of dopamine metabolic process. Reason: Consistent with TH inhibition and dopamine-handling modulation; non-core regulatory process. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; matches TH-inhibition/dopamine-handling data. |
| GO:0048148 behavioral response to cocaine | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) behavioral response to cocaine. Reason: A behavioural term from rat; peripheral to molecular function. Non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; behavioural response reflects dopaminergic involvement. |
| GO:0048156 tau protein binding | IDA PMID:17408955 alpha-Synuclein and its disease-related mutants interact dif... | ACCEPT | Summary: IDA tau protein binding. Reason: alpha-synuclein binds tau directly (and stimulates its PKA-catalyzed phosphorylation); tau binding is a supported specific molecular function. Supporting Evidence: PMID:17408955 alpha-synuclein associates with the actin cytoskeleton and interacts with tau |
| GO:0048156 tau protein binding | IDA PMID:21127069 Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydro... | ACCEPT | Summary: IDA tau protein binding. Reason: alpha-synuclein binds tau directly (and stimulates its PKA-catalyzed phosphorylation); tau binding is a supported specific molecular function. Supporting Evidence: PMID:21127069 Ξ±-synuclein binds to phosphorylated Ser(214) of Tau and stimulates PKA-catalyzed Tau phosphorylation at Ser(262) |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:20039155 Association of metallothionein-III with oligodendroglial cyt... | KEEP AS NON CORE | Summary: Pountney group: IDA perinuclear region of cytoplasm (MSA inclusions). Reason: Perinuclear localization reported in the aggregation/inclusion context; peripheral. Non-core. Supporting Evidence: PMID:20039155 Immunofluorescence double labelling showed the co-localisation of alpha-synuclein and MT-III in GCIs in MSA tissue. |
| GO:0048487 beta-tubulin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) beta-tubulin binding. Reason: Tubulin binding is experimentally established (PMID:27628239, alpha2beta2 tetramer), so binding the beta subunit is consistent. Beta-tubulin binding is a child of tubulin binding; it is kept as non-core because the core function is stated at the tubulin level, which also covers the tetramer. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; tubulin binding is real, and this more specific sub-term is consistent with it. |
| GO:0048488 synaptic vesicle endocytosis | IBA GO_REF:0000033 | ACCEPT | Summary: IBA (PANTHER PTN000352385) synaptic vesicle endocytosis. Reason: Supported by the endocytosis/recycling data (PMID:18980610) and conserved; SV endocytosis is part of the presynaptic recycling role. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000352385 SUPPORTS TRANSFER Synuclein node; SV endocytosis grounded in mouse/rat data and PMID:18980610. |
| GO:0048488 synaptic vesicle endocytosis | ISS GO_REF:0000024 | ACCEPT | Summary: ISS (from mouse O55042) synaptic vesicle endocytosis. Reason: Sequence-similarity transfer from the mouse ortholog for SV endocytosis; consistent with experimental data. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:O55042 Β· Snca SUPPORTS TRANSFER Mouse alpha-synuclein ortholog; SV endocytosis conserved and experimentally supported. |
| GO:0048489 synaptic vesicle transport | IBA GO_REF:0000033 | ACCEPT | Summary: IBA (PANTHER PTN000352385) synaptic vesicle transport. Reason: alpha-synuclein regulates synaptic vesicle trafficking/recycling; a conserved presynaptic process. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000352385 SUPPORTS TRANSFER Synuclein node; synaptic-vesicle transport/recycling is the conserved presynaptic role. |
| GO:0050729 positive regulation of inflammatory response | IDA PMID:25533483 Parkinson's disease genes VPS35 and EIF4G1 interact genetica... | KEEP AS NON CORE | Summary: Dhungel/Gitler (VPS35/EIF4G1 study): IDA positive regulation of inflammatory response. Reason: Positive regulation of inflammatory response is a disease/model-context observation and peripheral to the presynaptic molecular function. Non-core. Supporting Evidence: PMID:25533483 We also show interactions between VPS35, EIF4G1, and Ξ±-synuclein, a protein with a key role in PD. |
| GO:0050808 synapse organization | IBA GO_REF:0000033 | ACCEPT | Summary: IBA (PANTHER PTN000352385) synapse organization. Reason: Synucleins contribute to synapse maintenance/organization (triple-knockout neurological decline); a conserved role. Sound node placement. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000352385 SUPPORTS TRANSFER Synuclein node; synapse maintenance/organization supported by triple-KO phenotype (PMID:20798282). |
| GO:0051219 phosphoprotein binding | IDA PMID:21127069 Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydro... | ACCEPT | Summary: Qureshi and Paudel: IDA phosphoprotein binding (binds phospho-Ser214 tau). Reason: Direct binding to a phosphorylated protein (phospho-tau) is shown; a supported specific binding function. Supporting Evidence: PMID:21127069 Ξ±-synuclein binds to phosphorylated Ser(214) of Tau and stimulates PKA-catalyzed Tau phosphorylation at Ser(262) |
| GO:0051262 protein tetramerization | IDA PMID:21841800 Ξ±-Synuclein occurs physiologically as a helically folded tet... | ACCEPT | Summary: Bartels et al.: IDA protein tetramerization (helical tetramer). Reason: The native helical tetramer is a reported physiological quaternary state; self-tetramerization is a genuine molecular property (though its predominance is debated, PMID:22315227). Supporting Evidence: PMID:21841800 endogenous Ξ±-synuclein isolated and analysed under non-denaturing conditions from neuronal and non-neuronal cell lines, brain tissue and living human cells occurs in large part as a folded tetramer of about 58 kDa |
| GO:0051281 positive regulation of release of sequestered calcium ion into cytosol | IDA PMID:15641770 Fluorescence studies suggest a role for alpha-synuclein in t... | KEEP AS NON CORE | Summary: Narayanan et al.: IDA; alpha-synuclein enhances release of sequestered Ca2+ into the cytosol via PLCbeta2. Reason: Enhancement of intracellular Ca2+ release is shown through a proposed PLCbeta2/PI(4,5)P2 pathway; a context-specific signalling effect. Non-core. Supporting Evidence: PMID:15641770 in cultured cells the presence of alpha-synuclein results in a 6-fold enhancement in the release of Ca(2+) from intracellular stores |
| GO:0051583 dopamine uptake involved in synaptic transmission | TAS PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | MARK AS OVER ANNOTATED | Summary: TAS (Meloni and Vasak) dopamine uptake involved in synaptic transmission. Reason: The cited bioinorganic paper does not assay dopamine uptake. alpha-synuclein modulates the dopamine transporter (PMID:12958153), i.e. negatively regulates uptake, so an 'involved_in dopamine uptake' positive framing with this citation is inappropriate. Supporting Evidence: PMID:12958153 alpha-synuclein induced a 35% decrease in [3H]DA uptake |
| GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission | IDA PMID:12958153 Modulation of dopamine transporter function by alpha-synucle... | KEEP AS NON CORE | Summary: Wersinger et al.: IDA; alpha-synuclein decreases DAT-mediated dopamine uptake. Reason: Negative regulation of dopamine uptake via DAT modulation is experimentally supported; a genuine but non-core regulatory role (largely from overexpression/co-transfection). Supporting Evidence: PMID:12958153 alpha-synuclein induced a 35% decrease in [3H]DA uptake |
| GO:0051612 negative regulation of serotonin uptake | IDA PMID:16882008 Modulation of the trafficking of the human serotonin transpo... | KEEP AS NON CORE | Summary: Wersinger et al.: IDA negative regulation of serotonin uptake (SERT). Reason: SERT modulation shown by co-transfection; a peripheral transporter-regulation role. Non-core. Supporting Evidence: PMID:16882008 Increasing expression levels of human alpha-Syn gradually decreased [(3)H]5-HT uptake by human SERT |
| GO:0051621 regulation of norepinephrine uptake | IGI PMID:18331289 Regulated interactions of the norepineprhine transporter by ... | KEEP AS NON CORE | Summary: Jeannotte and Sidhu: IGI regulation of norepinephrine uptake (actin-dependent NET interaction). Reason: NET regulation shown via genetic/pharmacological interaction with the actin cytoskeleton; peripheral transporter-regulation role. Non-core. Supporting Evidence: PMID:18331289 This is the first direct demonstration of NET activity being regulated via actin and modulated by interactions with alpha-Syn. |
| GO:0051622 negative regulation of norepinephrine uptake | IDA PMID:17156375 Attenuation of the norepinephrine transporter activity and t... | KEEP AS NON CORE | Summary: Wersinger et al.: IDA negative regulation of norepinephrine uptake (NET). Reason: NET activity/trafficking attenuated by alpha-synuclein (co-transfection); peripheral. Non-core. Supporting Evidence: PMID:17156375 observed a progressive decrease (68%) in [3H]-NE uptake in cells co-transfected with a ratio of 3:1 alpha-Syn:NET DNA |
| GO:0055074 calcium ion homeostasis | IDA NOT PMID:12239163 Evidence that alpha-synuclein functions as a negative regula... | KEEP AS NON CORE | Summary: NOT annotation: Park et al. found alpha-synuclein did not change platelet Ca2+ levels. Reason: The paper reports no change in resting/stimulated platelet Ca2+ with added alpha-synuclein, supporting the NOT (calcium ion homeostasis) in that context. Keep the negative statement; non-core. Supporting Evidence: PMID:12239163 alpha-synuclein may function as a specific negative regulator of alpha-granule release in platelets |
| GO:0060732 positive regulation of inositol phosphate biosynthetic process | IDA PMID:15641770 Fluorescence studies suggest a role for alpha-synuclein in t... | KEEP AS NON CORE | Summary: Narayanan et al.: IDA positive regulation of inositol phosphate biosynthetic process (PLCbeta2). Reason: Enhanced inositol-phosphate production via the proposed PLCbeta2 interaction; context-specific signalling effect. Non-core. Supporting Evidence: PMID:15641770 Alpha-synuclein also enhances the increase in the level of inositol phosphates seen upon G protein stimulation |
| GO:0060961 phospholipase D inhibitor activity | IDA NOT PMID:19146388 Evidence that alpha-synuclein does not inhibit phospholipase... | KEEP AS NON CORE | Summary: NOT annotation: Rappley et al. found alpha-synuclein does not inhibit PLD. Reason: The NOT (phospholipase D inhibitor activity) is directly supported: carefully controlled assays failed to reproduce PLD inhibition. Keep the negation. Supporting Evidence: PMID:19146388 we observed no significant inhibition of PLD by alphaSyn in any of these systems |
| GO:0070495 negative regulation of thrombin-activated receptor signaling pathway | IDA PMID:12239163 Evidence that alpha-synuclein functions as a negative regula... | MARK AS OVER ANNOTATED | Summary: Park et al.: IDA; annotated as negative regulation of thrombin-activated receptor signaling. Reason: The thrombin-induced readout is alpha-granule secretion (equally inhibited by ionomycin), i.e. a downstream secretory step, not thrombin-receptor (PAR) signal transduction. The receptor-signaling term is mis-chosen. Supporting Evidence: PMID:12239163 ionomycin- or thrombin-induced alpha-granule secretion was inhibited by exogenous alpha-synuclein addition in a dose-dependent manner |
| GO:0070507 regulation of microtubule cytoskeleton organization | ISS GO_REF:0000024 | ACCEPT | Summary: ISS (from mouse O55042) regulation of microtubule cytoskeleton organization. Reason: Consistent with the experimental microtubule-dynamase and microtubule-destabilization data; a supported role transferred from the mouse ortholog. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:O55042 Β· Snca SUPPORTS TRANSFER Mouse ortholog; microtubule-organization regulation matches human experimental data (PMID:27628239, PMID:21127069). |
| GO:0070555 response to interleukin-1 | IDA PMID:12406186 Upregulation of alpha-synuclein by lipopolysaccharide and in... | KEEP AS NON CORE | Summary: Tanji et al.: IDA response to interleukin-1 (IL-1beta upregulates alpha-synuclein in macrophages). Reason: An inflammatory expression response in macrophages; peripheral to presynaptic function. Non-core. Supporting Evidence: PMID:12406186 levels of alpha-synuclein protein were increased by stimulation with lipopolysaccharide and interleukin-1beta |
| GO:0070840 dynein complex binding | IPI PMID:16176937 Molecular motors implicated in the axonal transport of tau a... | UNDECIDED | Summary: Utton et al.: dynein complex binding (IPI); the paper carries a 2024 expression of concern. Reason: Dynein-complex binding comes from the same paper now under an expression of concern; the evidence cannot be relied upon. UNDECIDED pending re-evaluation. Supporting Evidence: PMID:16176937 Co-immunoprecipitation experiments demonstrate that tau and alpha-synuclein are each associated with complexes containing kinesin-1, whereas only alpha-synuclein appears to interact with dynein-containing complexes. PMID:16176937 Expression of concern in |
| GO:0071280 cellular response to copper ion | IDA PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | KEEP AS NON CORE | Summary: Meloni and Vasak: IDA cellular response to copper ion. Reason: Copper-induced redox chemistry of the alpha-Syn-Cu complex; a biochemical response relevant in the disease/metal context. Non-core. Supporting Evidence: PMID:21320589 The observed metal-centered redox chemistry significantly promotes the production of hydroxyl radicals and Ξ±-Syn oxidation and oligomerization |
| GO:0071872 cellular response to epinephrine stimulus | TAS PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | MARK AS OVER ANNOTATED | Summary: TAS (Meloni and Vasak) cellular response to epinephrine stimulus. Reason: The cited bioinorganic paper does not assay an epinephrine response. The term is not supported by this citation and is not an established alpha-synuclein function. Supporting Evidence: PMID:21320589 These studies provide new insights into the bioinorganic chemistry of PD. |
| GO:0097413 Lewy body | IDA PMID:27273569 Ubiqutination via K27 and K29 chains signals aggregation and... | KEEP AS NON CORE | Summary: Ross group (WSB1 study): IDA; alpha-synuclein in Lewy bodies. Reason: Lewy-body localization is a disease aggregation state; non-core. Supporting Evidence: PMID:27273569 we found that WSB1 co-localizes with two markers (alpha-synuclein and ubiquitin) in Lewy bodies |
| GO:0097435 supramolecular fiber organization | TAS PMID:21320589 Redox activity of Ξ±-synuclein-Cu is silenced by Znβ-metallot... | MARK AS OVER ANNOTATED | Summary: TAS (Meloni and Vasak) supramolecular fiber organization. Reason: The cited bioinorganic paper addresses copper-promoted oligomerization/aggregation; fibril self-assembly is a disease process and this citation is not a dedicated study of fiber organization. The supramolecular-fiber (fibril) rows already capture aggregation. Over-annotation. Supporting Evidence: PMID:21320589 The observed metal-centered redox chemistry significantly promotes the production of hydroxyl radicals and Ξ±-Syn oxidation and oligomerization |
| GO:0098793 presynapse | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (Ensembl Compara from rat) presynapse. Reason: Presynaptic localization is the hallmark location of alpha-synuclein. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; presynapse localization is the core experimentally established location. |
| GO:0099512 supramolecular fiber | IDA PMID:17222866 Relationships between the sequence of alpha-synuclein and it... | KEEP AS NON CORE | Summary: IDA supramolecular fiber (amyloid fibrils). Reason: alpha-synuclein self-assembles into amyloid fibrils (supramolecular fibers); this is the disease aggregation state rather than the physiological function. Non-core. Supporting Evidence: PMID:17222866 Most of these contained a mutation to either proline or glutamic acid that caused a defect in membrane binding. |
| GO:0099512 supramolecular fiber | IDA PMID:18346205 FK506 binding protein 12 differentially accelerates fibril f... | KEEP AS NON CORE | Summary: IDA supramolecular fiber (amyloid fibrils). Reason: alpha-synuclein self-assembles into amyloid fibrils (supramolecular fibers); this is the disease aggregation state rather than the physiological function. Non-core. Supporting Evidence: PMID:18346205 fibril formation |
| GO:0099512 supramolecular fiber | IDA PMID:23507046 Ξ±-Synuclein-mediated defense against oxidative stress via mo... | KEEP AS NON CORE | Summary: IDA supramolecular fiber (amyloid fibrils). Reason: alpha-synuclein self-assembles into amyloid fibrils (supramolecular fibers); this is the disease aggregation state rather than the physiological function. Non-core. Supporting Evidence: PMID:23507046 The entrapped enzyme was demonstrated to be protected in a latent form and its activity was fully recovered as released from the matrix. |
| GO:0140311 protein sequestering activity | IDA PMID:23507046 Ξ±-Synuclein-mediated defense against oxidative stress via mo... | KEEP AS NON CORE | Summary: Koo et al.: IDA protein sequestering activity (fibrils act as an active depot for GPX-1). Reason: alpha-synuclein fibrils sequester/protect GPX-1 as a latent depot; a property of the fibrillar state. Non-core. Supporting Evidence: PMID:23507046 The entrapped enzyme was demonstrated to be protected in a latent form and its activity was fully recovered as released from the matrix. |
| GO:0141108 transporter regulator activity | IGI PMID:18331289 Regulated interactions of the norepineprhine transporter by ... | KEEP AS NON CORE | Summary: Jeannotte and Sidhu: IGI transporter regulator activity (NET). Reason: Captures the transporter-modulation role (NET, DAT, SERT) as a molecular function; genuine but peripheral and largely from overexpression. Non-core. Supporting Evidence: PMID:18331289 This is the first direct demonstration of NET activity being regulated via actin and modulated by interactions with alpha-Syn. |
| GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone | TAS PMID:24252804 The role of oxidative stress in Parkinson's disease. | MARK AS OVER ANNOTATED | Summary: TAS (oxidative-stress review) negative regulation of mitochondrial electron transport (NADH to ubiquinone / complex I). Reason: Complex-I inhibition by alpha-synuclein binding the inner mitochondrial membrane is a disease/overexpression phenomenon summarized in a review; not an established physiological function. Over-annotation. Supporting Evidence: PMID:24252804 PD causing gene products including DJ-1, PINK1, parkin, alpha-synuclein and LRRK2 also impact in complex ways mitochondrial function leading to exacerbation of ROS generation and susceptibility to oxidative stress. |
| GO:1903136 cuprous ion binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA (PANTHER PTN000352385) cuprous ion binding, with the gene's own experimental annotation among seeds. Reason: Cu(I) binding is experimentally supported (PMID:25495902) and conserved; peripheral to the presynaptic core. The target appearing in WITH/FROM is expected. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000352385 SUPPORTS TRANSFER Synuclein node; Cu(I) binding grounded on the target's own IMP (PMID:25495902) and the beta-synuclein donor. |
| GO:1903136 cuprous ion binding | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA (ARBA) cuprous ion binding. Reason: Electronic ARBA row consistent with experimental Cu(I) binding; non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: ARBA:ARBA00090020 SUPPORTS TRANSFER ARBA rule; Cu(I) binding matches experimental data (PMID:25495902). |
| GO:1903136 cuprous ion binding | IMP PMID:25495902 Differences in the binding of copper(I) to Ξ±- and Ξ²-synuclei... | KEEP AS NON CORE | Summary: D'Angelo et al.: IMP cuprous ion binding (Cu(I) coordination by the N-terminus). Reason: Direct Cu(I) binding established by NMR/CD/XAS; a genuine biochemical property, peripheral to core function. Supporting Evidence: PMID:25495902 Coordination modes 3S1O and 2S2O were identified for Ξ²S and Ξ±S, respectively. |
| GO:1903285 positive regulation of hydrogen peroxide catabolic process | IDA PMID:23507046 Ξ±-Synuclein-mediated defense against oxidative stress via mo... | KEEP AS NON CORE | Summary: Koo et al.: IDA positive regulation of hydrogen peroxide catabolic process (via GPX-1). Reason: Through stimulating GPX-1, alpha-synuclein could promote H2O2 catabolism; single-report, non-core. Supporting Evidence: PMID:23507046 Ξ±-synuclein enhanced the GPX-1 activity with Kd of 17.3nM and the enzyme in turn markedly enhanced in vitro fibrillation of Ξ±-synuclein |
| GO:1903421 regulation of synaptic vesicle recycling | TAS PMID:23983262 Polo-like kinase 2 regulates selective autophagic Ξ±-synuclei... | ACCEPT | Summary: Oueslati et al. (TAS): alpha-synuclein regulates synaptic vesicle recycling. Reason: Regulation of synaptic vesicle recycling is a well-supported presynaptic process (also PMID:18980610). Accept. Supporting Evidence: PMID:23983262 Ξ±-syn is rather considered to regulate synaptic transmission at the presynaptic level, by modulating the recycling of synaptic vesicles |
| GO:1903426 regulation of reactive oxygen species biosynthetic process | TAS PMID:24252804 The role of oxidative stress in Parkinson's disease. | MARK AS OVER ANNOTATED | Summary: TAS (oxidative-stress review) regulation of reactive oxygen species biosynthetic process. Reason: ROS generation linked to alpha-synuclein is a disease-context consequence (mitochondrial dysfunction, Cu redox, microglial activation) summarized in a review, not a dedicated physiological regulatory function. Over-annotation. Supporting Evidence: PMID:24252804 PD causing gene products including DJ-1, PINK1, parkin, alpha-synuclein and LRRK2 also impact in complex ways mitochondrial function leading to exacerbation of ROS generation and susceptibility to oxidative stress. |
| GO:1904307 response to desipramine | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (Ensembl Compara from rat) response to desipramine. Reason: A pharmacological-response term (desipramine is an NET inhibitor) transferred from rat; peripheral, consistent with the transporter-modulation role. Non-core. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:P37377 SUPPORTS TRANSFER Rat ortholog; desipramine-response reflects noradrenergic transporter involvement, peripheral. |
| GO:1904377 positive regulation of protein localization to cell periphery | IGI PMID:25533483 Parkinson's disease genes VPS35 and EIF4G1 interact genetica... | KEEP AS NON CORE | Summary: Dhungel/Gitler: IGI positive regulation of protein localization to cell periphery. Reason: From the VPS35/EIF4G1 genetic-interaction study (yeast/model); a context-specific trafficking effect. Non-core. Supporting Evidence: PMID:25533483 We also show interactions between VPS35, EIF4G1, and Ξ±-synuclein, a protein with a key role in PD. |
| GO:1904715 negative regulation of chaperone-mediated autophagy | IMP PMID:20697033 Chaperone-mediated autophagy markers in Parkinson disease br... | KEEP AS NON CORE | Summary: Alvarez-Erviti et al.: IMP; reduced CMA increases alpha-synuclein half-life. Reason: alpha-synuclein is a CMA substrate whose degradation is impaired by post-translational modification; the IMP shows that reduced LAMP2A increases its half-life, consistent with alpha-synuclein (especially modified forms) negatively affecting CMA. A disease-context regulatory effect; non-core. Supporting Evidence: PMID:20697033 decreased LAMP2A levels in dopaminergic cell lines reduced chaperone-mediated autophagy activity and increased the half-life of Ξ±-synuclein |
| GO:1905606 regulation of presynapse assembly | IGI PMID:25533483 Parkinson's disease genes VPS35 and EIF4G1 interact genetica... | KEEP AS NON CORE | Summary: Dhungel/Gitler: IGI regulation of presynapse assembly. Reason: A genetic-interaction-based presynapse-assembly regulation; consistent with synapse-maintenance roles but context-specific. Non-core. Supporting Evidence: PMID:25533483 We also show interactions between VPS35, EIF4G1, and Ξ±-synuclein, a protein with a key role in PD. |
| GO:1990000 amyloid fibril formation | EXP PMID:8901511 NACP, a protein implicated in Alzheimer's disease and learni... | ACCEPT | Summary: Weinreb et al.: EXP amyloid fibril formation (natively unfolded NACP). Reason: alpha-synuclein (NACP) self-assembles into amyloid fibrils; this is the defining aggregation process underlying synucleinopathies. Accept as a (pathological) process the protein directly performs. Supporting Evidence: PMID:8901511 NACP exists as a mixture of rapidly equilibrating extended conformers and is representative of a class of "natively unfolded" proteins |
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Download this section (compressed HTML)Q: What is the physiological stoichiometry and functional role of the proposed helical alpha-synuclein tetramer versus the disordered monomer, and how does the monomer/multimer equilibrium control SNARE chaperoning versus aggregation?
Suggested experts: alpha-synuclein structural biologist, presynaptic biology expert
Q: Does the high-affinity N-terminal copper site have a defined physiological role (copper buffering or redox modulation) distinct from its contribution to metal-promoted aggregation?
Suggested experts: metalloprotein biochemist, Parkinson disease neurochemist
Q: Which of the many reported monoamine-transporter and enzyme modulations (DAT, SERT, NET, tyrosine hydroxylase) reflect direct endogenous presynaptic functions rather than overexpression artifacts?
Suggested experts: dopaminergic neurotransmission expert, membrane transporter biochemist
Q: Is nuclear alpha-synuclein a regulated physiological pool with a defined function (e.g. histone binding) or primarily a stress/disease redistribution?
Suggested experts: chromatin biology expert, neurodegeneration cell biologist
Experiment: Use endogenous-locus, fragment- and multimer-selective alpha-synuclein alleles (and synuclein triple-knockout rescue) in neurons to separate SNARE-chaperone, vesicle-priming, fusion-pore and endocytic-recycling functions of the monomer versus the membrane-bound multimer.
Hypothesis: The membrane-bound multimer performs SNARE chaperoning while soluble monomer promotes priming/fusion; these are separable physiological activities.
Type: endogenous allele engineering and presynaptic physiology
Experiment: Quantify copper occupancy of endogenous alpha-synuclein in neurons and test copper-binding-site mutants for effects on redox state, aggregation kinetics and neuronal survival.
Hypothesis: Physiological copper binding buffers or redox-modulates alpha-synuclein independently of its role in metal-promoted aggregation.
Type: metalloprotein biochemistry and cell-based copper-handling assays
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