SNORD116-1 is one paralogous box C/D small nucleolar RNA copy within the paternally expressed SNORD116 tandem repeat cluster in the imprinted SNHG14 / SNURF-SNRPN locus on chromosome 15q11-q13. The strongest per-copy evidence is class-based snoRNA biology: intron-derived snoRNA processing, snoRNP association, and nucleolar localization. Prader-Willi syndrome and neurodevelopmental phenotypes are supported mainly at the SNORD116 cluster/locus level, so they should not be treated as direct, copy-specific core functions of SNORD116-1.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0006396 RNA processing | IEA GO_REF:0000115 | ACCEPT | Summary: Standard snoRNA annotation - all SNORD116 copies function in RNA processing as C/D box snoRNAs Supporting Evidence: GO_REF:0000115 Rfam classification as C/D box snoRNA (RF00108) file:human/SNORD116-1/SNORD116-1-deep-research-falcon.md SNORD116 family members behave as bona fide box C/D snoRNAs that assemble with core snoRNP proteins. |
| GO:0005730 nucleolus | IEA GO_REF:0000115 | ACCEPT | Summary: Standard localization for C/D box snoRNAs - nucleolar localization expected for all cluster members Supporting Evidence: GO_REF:0000115 Rfam classification indicates nucleolar localization file:human/SNORD116-1/SNORD116-1-deep-research-falcon.md Box C/D snoRNAs are described as concentrating mainly in the nucleolus, and SNORD116 snoRNAs are described as localizing to nucleoli. |
| GO:0003723 RNA binding | NAS | NEW | Summary: Added to align core_functions with existing annotations. Reason: Core function term not present in existing_annotations. Supporting Evidence: file:human/SNORD116-1/SNORD116-1-deep-research-falcon.md Fibrillarin RIP-seq enrichment over the first third of the SNORD116 cluster supports snoRNP association for that region, aligning with SNOG1, which includes SNORD116-1. |
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Download this section (compressed HTML)Q: What is the complete set of mRNA targets regulated by the SNORD116 cluster in different tissues?
Suggested experts: RNA biologists, Prader-Willi syndrome researchers
Q: Do individual SNORD116 copies have redundant or specialized functions within the cluster?
Suggested experts: snoRNA biologists, geneticists
Q: How does SNORD116 cluster dosage affect hypothalamic neuron development and function?
Suggested experts: neurodevelopmental biologists, neuroendocrinologists
Experiment: CLIP-seq analysis of SNORD116 interactions with mRNAs in hypothalamic neurons
Hypothesis: SNORD116 cluster binds to a specific set of mRNAs critical for hypothalamic function
Type: high-throughput sequencing
Experiment: Single-cell RNA-seq of hypothalamic development in SNORD116 cluster knockout models
Hypothesis: SNORD116 cluster loss affects specific neuronal subtypes in the hypothalamus
Type: single-cell analysis
Experiment: Functional analysis of individual SNORD116 copies to test redundancy vs. specialization
Hypothesis: Individual copies within the cluster may have partially redundant functions
Type: molecular genetics
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