SOS1 (Son of sevenless homolog 1) is a large multidomain cytoplasmic guanine-nucleotide exchange factor (GEF) that activates RAS-family small GTPases. Through its central REM-CDC25 (Ras-GEF) module it catalyzes release of GDP from H-, N- and K-RAS, allowing GTP to load and switch RAS into its active signaling state; it does not hydrolyze or transfer nucleotide itself. SOS1 is recruited from the cytosol to the inner face of the plasma membrane downstream of activated receptor tyrosine kinases, where its proline-rich C-terminal tail binds the SH3 domains of the adaptor GRB2 (docked on phosphorylated receptors or SHC), positioning SOS1 next to lipid-anchored RAS. Its activity is tightly regulated: an N-terminal histone-fold/DH-PH region autoinhibits the catalytic module, and this is relieved by membrane lipids and by RAS-GTP binding an allosteric REM-CDC25 site that drives positive feedback. SOS1 thereby acts as a key activating node of the RAS-RAF-MEK-ERK (MAPK) cascade controlling proliferation, differentiation, survival and migration downstream of many growth-factor, cytokine and antigen receptors. In addition to RAS-GEF activity, its Dbl-homology (DH) domain, acting in complexes such as EPS8-ABI1, links RAS signaling to activation of the RHO-family GTPase RAC1 and cytoskeletal/JNK signaling, and SOS1 can act as a scaffold within phase-separated receptor signalosomes. Germline gain-of-function variants dysregulate RAS-MAPK signaling and cause Noonan syndrome and hereditary gingival fibromatosis.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0002931 response to ischemia | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Response to ischemia (IEA from rat ortholog). Reason: Pleiotropic stress-response context downstream of RAS signaling; non-core. |
| GO:0005085 guanyl-nucleotide exchange factor activity | EXP PMID:1371879 p21ras activation via hemopoietin receptors and c-kit requir... | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | EXP PMID:16483568 Stem cell factor and its receptor c-Kit as targets for infla... | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | EXP PMID:7731718 The motogenic and mitogenic responses to HGF are amplified b... | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | IBA GO_REF:0000033 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | IDA PMID:8479536 Association of Sos Ras exchange protein with Grb2 is implica... | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | IEA GO_REF:0000120 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS PMID:8493579 Human Sos1: a guanine nucleotide exchange factor for Ras tha... | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. Supporting Evidence: PMID:8493579 This hSos1 domain specifically stimulated guanine nucleotide exchange on mammalian Ras proteins in vitro |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS PMID:9790532 Crystal structure of the Dbl and pleckstrin homology domains... | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-177938 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-177945 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-186834 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-210977 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-2424477 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-392054 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-9607304 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-9670436 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-9672170 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-9695853 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005085 guanyl-nucleotide exchange factor activity | TAS Reactome:R-HSA-9703441 | ACCEPT | Summary: SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein. Reason: Core, well-established molecular function demonstrated biochemically and structurally; the founding study showed the CDC25-related domain stimulates nucleotide exchange on Ras [PMID:8493579]. Applies across evidence codes (EXP/IDA/IBA/IEA/TAS); the IBA (PANTHER:PTN000560991) sits on the RasGEF/CDC25 clade and is well grounded, with Q07889 legitimately among its experimental descendant evidences. |
| GO:0005096 GTPase activator activity | TAS PMID:9790532 Crystal structure of the Dbl and pleckstrin homology domains... | MODIFY | Summary: Annotated as GTPase activator (GAP) activity, but SOS1 is a guanine-nucleotide exchange factor, not a GAP. Reason: GO:0005096 (GTPase activator activity) denotes stimulation of GTP hydrolysis (GAP function). SOS1 does the opposite regulatory chemistry: it accelerates GDP release/nucleotide exchange to activate RAS. This is a legacy ProtInc term-choice error; replace with guanyl-nucleotide exchange factor activity. Proposed replacements: guanyl-nucleotide exchange factor activity |
| GO:0005154 epidermal growth factor receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Epidermal growth factor receptor binding (IEA from rat ortholog). Reason: SOS1 co-precipitates with EGFR (IntAct Q07889;P00533) and functions downstream of EGFR, but receptor coupling is chiefly GRB2/SH3-mediated. A real but non-core interaction. |
| GO:0005515 protein binding | IPI PMID:10026169 Identification of Grb4/Nckbeta, a src homology 2 and 3 domai... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:10026169 Identification of Grb4/Nckbeta, a src homology 2 and 3 domai... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:10206341 Characterization of interactions of Nck with Sos and dynamin... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:12029088 Identification of novel SH3 domain ligands for the Src famil... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:12482578 Interaction of nebulin SH3 domain with titin PEVK and myopal... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:12628188 Structural evidence for feedback activation by Ras.GTP of th... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:14679214 A novel proteomic screen for peptide-protein interactions. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:14679214 A novel proteomic screen for peptide-protein interactions. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:14679214 A novel proteomic screen for peptide-protein interactions. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:15507210 Structural analysis of autoinhibition in the Ras activator S... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:16520382 Sos-mediated activation of rac1 by p66shc. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:17084389 Catalytic competence of the Ras-GEF domain of hSos1 requires... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:17141806 Solution structure of a Hck SH3 domain ligand complex reveal... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:17515907 Structural basis for the transforming activity of human canc... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:18454158 Membrane-dependent signal integration by the Ras activator S... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:19141281 Differences in flexibility underlie functional differences i... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:19323566 SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within t... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:19464300 Isoform-selective interaction of the adaptor protein Tks5/FI... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:20133692 Role of the histone domain in the autoinhibition and activat... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:20473329 SIRPalpha1 receptors interfere with the EGFRvIII signalosome... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:20473329 SIRPalpha1 receptors interfere with the EGFRvIII signalosome... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:23397142 Analysis of protein-protein interactions in cross-talk pathw... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:26005835 RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and rest... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:30631038 The CSN3 subunit of the COP9 signalosome interacts with the ... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:31820037 Elucidation of protein interactions necessary for the mainte... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:34591642 A protein network map of head and neck cancer reveals PIK3CA... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:7527391 Independent binding of peptide ligands to the SH2 and SH3 do... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:7629138 Differential interactions of human Sos1 and Sos2 with Grb2. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:7773779 NMR structure of the N-terminal SH3 domain of GRB2 and its c... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:9020117 Subsets of epidermal growth factor receptors during activati... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:9447984 Regulation of Sos activity by intramolecular interactions. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:9447984 Regulation of Sos activity by intramolecular interactions. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:9544989 Shc phosphotyrosine-binding domain dominantly interacts with... | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:9569023 Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005515 protein binding | IPI PMID:9690470 The structural basis of the activation of Ras by Sos. | REMOVE | Summary: Generic 'protein binding' with no functional information. Reason: GO:0005515 conveys no specific molecular function. The functionally informative interactions of SOS1 are captured by specific terms (SH3 domain binding for GRB2, EGFR binding, and guanyl-nucleotide exchange factor activity / GTPase complex for RAS). Removal does not assert the reported interaction is false; many of these are also high-throughput interactome screens. |
| GO:0005737 cytoplasm | IDA PMID:17515907 Structural basis for the transforming activity of human canc... | ACCEPT | Summary: Cytoplasmic localization. Reason: Inactive SOS1 is a soluble cytoplasmic protein; consistent with its biology. |
| GO:0005829 cytosol | IEA GO_REF:0000117 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-109813 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-109822 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-109823 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1225950 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1225951 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1225957 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1225961 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1250380 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1250383 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1306969 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1306972 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433471 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177936 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177938 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177943 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177945 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-186826 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-186834 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205039 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205244 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205286 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-210974 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-210977 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2179407 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2179415 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2396561 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2396594 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2396599 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2396606 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424476 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424477 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424481 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424484 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424485 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424486 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424487 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730833 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730837 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730840 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730841 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730842 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730844 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730847 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730851 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730856 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730858 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730870 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730889 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730892 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-354165 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-392053 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-392054 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-419166 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453111 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637770 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637798 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637806 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637808 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654392 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654402 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654406 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654413 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654416 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654423 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654426 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654586 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654597 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654600 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654615 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654618 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654646 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654647 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654663 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654664 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655233 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655241 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655266 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655277 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655295 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655326 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655347 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655348 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5685366 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5686073 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5686074 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5686315 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-74736 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-74746 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851804 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851827 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851859 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851877 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851899 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851900 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8853734 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854899 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9032073 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9607301 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9607304 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9634402 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9634418 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664983 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664991 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665000 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665009 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665404 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665408 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665409 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665413 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665698 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665699 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665700 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665707 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670428 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670436 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672158 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672163 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672164 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672170 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9695845 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9695853 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9703430 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9703441 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-983703 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9842669 | ACCEPT | Summary: Cytosolic localization. Reason: SOS1 is predominantly cytosolic when inactive; consistent across the ARBA IEA and Reactome TAS records for the GRB2:SOS1 signaling reactions. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange. Reason: SOS1 performs its catalytic work at the cytoplasmic face of the plasma membrane where lipid-anchored RAS resides; the IBA (is_active_in) correctly places the active location there. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1112666 | ACCEPT | Summary: Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange. Reason: SOS1 performs its catalytic work at the cytoplasmic face of the plasma membrane where lipid-anchored RAS resides; the IBA (is_active_in) correctly places the active location there. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9606151 | ACCEPT | Summary: Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange. Reason: SOS1 performs its catalytic work at the cytoplasmic face of the plasma membrane where lipid-anchored RAS resides; the IBA (is_active_in) correctly places the active location there. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9691421 | ACCEPT | Summary: Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange. Reason: SOS1 performs its catalytic work at the cytoplasmic face of the plasma membrane where lipid-anchored RAS resides; the IBA (is_active_in) correctly places the active location there. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-983703 | ACCEPT | Summary: Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange. Reason: SOS1 performs its catalytic work at the cytoplasmic face of the plasma membrane where lipid-anchored RAS resides; the IBA (is_active_in) correctly places the active location there. |
| GO:0006357 regulation of transcription by RNA polymerase II | IDA PMID:23027131 Wnt4 inhibits cell motility induced by oncogenic Ras. | MARK AS OVER ANNOTATED | Summary: Regulation of transcription by RNA polymerase II. Reason: SOS1 is a cytoplasmic RasGEF and performs no step of RNA Pol II transcription; any transcriptional effect is indirect via RAS-MAPK. The cited paper [PMID:23027131] concerns Wnt4/Ras control of cell motility, not SOS1 acting on transcription. Over-annotation of an indirect downstream effect. |
| GO:0007165 signal transduction | NAS PMID:8493579 Human Sos1: a guanine nucleotide exchange factor for Ras tha... | MODIFY | Summary: Signal transduction (NAS) is too general for SOS1's role. Reason: The specific process is RAS protein signal transduction, already present in the annotation set; generalize this uninformative parent term to the specific one. Proposed replacements: Ras protein signal transduction |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:8663461 Insulin and epidermal growth factor receptors regulate disti... | ACCEPT | Summary: Epidermal growth factor receptor signaling pathway. Reason: Core process: SOS1 is the GRB2-recruited RasGEF that activates RAS downstream of EGFR [PMID:8663461]. Supporting Evidence: PMID:8663461 Insulin and epidermal growth factor (EGF) stimulate a rapid but transient increase in the amount of GTP bound to Ras |
| GO:0007173 epidermal growth factor receptor signaling pathway | TAS Reactome:R-HSA-177929 | ACCEPT | Summary: Epidermal growth factor receptor signaling pathway. Reason: Core process: SOS1 is the GRB2-recruited RasGEF that activates RAS downstream of EGFR [PMID:8663461]. |
| GO:0007264 small GTPase-mediated signal transduction | IEA GO_REF:0000002 | ACCEPT | Summary: Small GTPase mediated signal transduction. Reason: Correct, if general (parent of Ras protein signal transduction); consistent with the GEF function. |
| GO:0007265 Ras protein signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: Ras protein signal transduction. Reason: Core process directly enabled by SOS1's RAS-GEF activity; SOS1 loads RAS with GTP to drive RAS signaling [PMID:38188543]. |
| GO:0007265 Ras protein signal transduction | IDA PMID:23027131 Wnt4 inhibits cell motility induced by oncogenic Ras. | ACCEPT | Summary: Ras protein signal transduction. Reason: Core process directly enabled by SOS1's RAS-GEF activity; SOS1 loads RAS with GTP to drive RAS signaling [PMID:38188543]. |
| GO:0007265 Ras protein signal transduction | IDA PMID:38188543 Studying early structural changes in SOS1 mediated KRAS acti... | ACCEPT | Summary: Ras protein signal transduction. Reason: Core process directly enabled by SOS1's RAS-GEF activity; SOS1 loads RAS with GTP to drive RAS signaling [PMID:38188543]. Supporting Evidence: PMID:38188543 SOS1 facilitates the exchange of GDP to GTP thereby leading to activation of KRAS |
| GO:0007265 Ras protein signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: Ras protein signal transduction. Reason: Core process directly enabled by SOS1's RAS-GEF activity; SOS1 loads RAS with GTP to drive RAS signaling [PMID:38188543]. |
| GO:0007265 Ras protein signal transduction | TAS PMID:8493579 Human Sos1: a guanine nucleotide exchange factor for Ras tha... | ACCEPT | Summary: Ras protein signal transduction. Reason: Core process directly enabled by SOS1's RAS-GEF activity; SOS1 loads RAS with GTP to drive RAS signaling [PMID:38188543]. |
| GO:0007411 axon guidance | TAS Reactome:R-HSA-422475 | KEEP AS NON CORE | Summary: Axon guidance (Reactome pathway context). Reason: SOS1 participates as the GRB2/RasGEF node downstream of guidance receptors; context-specific, non-core. |
| GO:0008286 insulin receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Insulin receptor signaling pathway. Reason: SOS1 acts downstream of the insulin receptor via GRB2; real but a context-specific application of the core GEF role. |
| GO:0014044 Schwann cell development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Schwann cell development (IEA from mouse ortholog). Reason: Developmental/pleiotropic consequence of RAS-MAPK signaling; not a core SOS1 function. |
| GO:0014069 postsynaptic density | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Postsynaptic density (IEA from rat ortholog). Reason: Tissue-specific neuronal localization; not the general site of SOS1 action. |
| GO:0017124 SH3 domain binding | IEA GO_REF:0000107 | ACCEPT | Summary: SH3 domain binding: the SOS1 proline-rich tail binds GRB2 SH3 domains. Reason: Mechanistically central, informative molecular function underlying SOS1 recruitment to activated receptors via GRB2 [PMID:8493579]. |
| GO:0019221 cytokine-mediated signaling pathway | TAS Reactome:R-HSA-9607240 | KEEP AS NON CORE | Summary: Cytokine-mediated signaling pathway. Reason: SOS1 acts as the GRB2/RasGEF node downstream of cytokine receptors; context-specific, non-core. |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Protein kinase binding (IEA from mouse ortholog). Reason: SOS1 associates with kinases and is phosphorylated by ERK/RSK; a genuine but non-core, relatively generic binding annotation. |
| GO:0035022 positive regulation of Rac protein signal transduction | IC PMID:16475793 Binding of laminin alpha1-chain LG4-5 domain to alpha-dystro... | ACCEPT | Summary: Positive regulation of Rac protein signal transduction. Reason: SOS1's DH-PH module, acting in complexes (e.g. EPS8-ABI1) and cascades such as Grb2-Sos1-Rac1-PAK1-JNK, promotes RAC1 activation [PMID:16475793]. A genuine secondary function; autonomous DH-domain Rho-GEF activity in isolation is context-dependent. Supporting Evidence: PMID:16475793 by way of Grb2-Sos1-Rac1-PAK1-JNK ultimately results in the phosphorylation of c-jun on Ser(65) file:human/SOS1/SOS1-deep-research-falcon.md SOS1 directly performs only the RAS nucleotide-exchange step |
| GO:0038095 Fc-epsilon receptor signaling pathway | TAS Reactome:R-HSA-2454202 | KEEP AS NON CORE | Summary: Fc-epsilon receptor signaling pathway. Reason: SOS1 acts as the GRB2/RasGEF node downstream of FcΞ΅RI; context-specific, non-core. |
| GO:0042110 T cell activation | IDA PMID:7737275 T cell antigen CD28 binds to the GRB-2/SOS complex, regulato... | KEEP AS NON CORE | Summary: T cell activation. Reason: SOS1 participates in TCR/CD28 signaling, where CD28 binds the GRB2/SOS complex [PMID:7737275]; a context-specific application of the core RasGEF role. Supporting Evidence: PMID:7737275 T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras |
| GO:0042127 regulation of cell population proliferation | IDA PMID:9054499 Oncogenic ras provokes premature cell senescence associated ... | KEEP AS NON CORE | Summary: Regulation of cell population proliferation. Reason: Downstream RAS-MAPK output rather than a direct SOS1 molecular activity; pleiotropic, non-core. |
| GO:0042127 regulation of cell population proliferation | NAS PMID:38188543 Studying early structural changes in SOS1 mediated KRAS acti... | KEEP AS NON CORE | Summary: Regulation of cell population proliferation. Reason: Downstream RAS-MAPK output rather than a direct SOS1 molecular activity; pleiotropic, non-core. |
| GO:0042552 myelination | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Myelination (IEA from mouse ortholog). Reason: Developmental/pleiotropic consequence of RAS signaling; non-core. |
| GO:0043025 neuronal cell body | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Neuronal cell body (IEA from rat ortholog). Reason: Tissue-specific localization; not the general site of SOS1 action. |
| GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of epidermal growth factor receptor signaling pathway (IEA from rat ortholog). Reason: Reflects SOS1's positive role in EGFR pathway output; context-specific, non-core. |
| GO:0046982 protein heterodimerization activity | IEA GO_REF:0000002 | REMOVE | Summary: Protein heterodimerization activity mapped from the histone-fold InterPro signature. Reason: SOS1's histone folds form an intramolecular TANDEM pair that autoinhibits the catalytic module [PMID:15507210], not a heterodimerization interface with a partner protein. This InterPro2GO transfer is inappropriate for SOS1. |
| GO:0048009 insulin-like growth factor receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Insulin-like growth factor receptor signaling pathway (IEA from mouse ortholog). Reason: SOS1 acts as the GRB2/RasGEF node downstream of IGF1R; context-specific, non-core. |
| GO:0048011 neurotrophin TRK receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Neurotrophin TRK receptor signaling pathway (IEA from rat ortholog). Reason: SOS1 acts as the GRB2/RasGEF node downstream of TRK receptors; context-specific, non-core. |
| GO:0050853 B cell receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: B cell receptor signaling pathway (IEA from mouse ortholog). Reason: SOS1 acts as the GRB2/RasGEF node downstream of the BCR; context-specific, non-core. |
| GO:0050900 leukocyte migration | TAS Reactome:R-HSA-202733 | KEEP AS NON CORE | Summary: Leukocyte migration (Reactome pathway context). Reason: Downstream cellular process; SOS1 contributes via RAS/RAC signaling. Context-specific, non-core. |
| GO:0051057 positive regulation of small GTPase mediated signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: Positive regulation of small GTPase mediated signal transduction. Reason: Correct high-level process directly reflecting SOS1's GEF-driven activation of RAS (and RAC). |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Glutamatergic synapse (IEA from rat ortholog). Reason: Tissue-specific localization; not the general site of SOS1 action. |
| GO:0140693 molecular condensate scaffold activity | IDA PMID:27056844 Phase separation of signaling molecules promotes T cell rece... | ACCEPT | Summary: Molecular condensate scaffold activity in receptor signalosomes. Reason: In reconstituted TCR signaling, pLAT-GRB2-SOS1 phase-separate into clusters that promote signaling [PMID:27056844]; a documented distinct molecular function (DisProt IDA). Supporting Evidence: PMID:27056844 Upon addition of Grb2 and Sos1, submicron-sized clusters formed within 1 minute and gradually grew in size |
| GO:1905360 GTPase complex | IPI PMID:25695162 Small molecule binding sites on the Ras:SOS complex can be e... | ACCEPT | Summary: Part of the RAS:SOS1 GTPase complex. Reason: SOS1 forms a defined complex with RAS (ComplexPortal CPX-395/CPX-26660) that is a validated structural/drug-target entity [PMID:25695162]. Supporting Evidence: PMID:25695162 the discovery of three fragment binding sites on the Ras:SOS complex |
| GO:1905360 GTPase complex | IPI PMID:39043660 Allosteric nanobodies to study the interactions between SOS1... | ACCEPT | Summary: Part of the RAS:SOS1 GTPase complex. Reason: SOS1 forms a defined complex with RAS (ComplexPortal CPX-395/CPX-26660) that is a validated structural/drug-target entity [PMID:25695162]. Supporting Evidence: PMID:39043660 modulate the nucleotide exchange rate on this pivotal GTPase in vitro as well as RAS signalling in cellulo |
Loading supporting contentβ¦
Download this section (compressed HTML)Loading supporting contentβ¦
Download this section (compressed HTML)Loading supporting contentβ¦
Download this section (compressed HTML)Loading supporting contentβ¦
Download this section (compressed HTML)