GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q96JI7 SPG11 is_active_in GO:0005737 cytoplasm cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:2444989|PANTHER:PTN000342072|UniProtKB:Q96JI7 9606 Homo sapiens GO_Central Spatacsin 20251219 UniProtKB Q96JI7 SPG11 involved_in GO:0007409 axonogenesis biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:2444989|PANTHER:PTN000342074|ZFIN:ZDB-GENE-101017-1 9606 Homo sapiens GO_Central Spatacsin 20231212 UniProtKB Q96JI7 SPG11 involved_in GO:0007268 chemical synaptic transmission biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000342074|UniProtKB:Q96JI7 9606 Homo sapiens GO_Central Spatacsin 20200129 UniProtKB Q96JI7 SPG11 involved_in GO:0008088 axo-dendritic transport biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:2444989|PANTHER:PTN000342074|UniProtKB:Q96JI7 9606 Homo sapiens GO_Central Spatacsin 20200129 UniProtKB Q96JI7 SPG11 is_active_in GO:0030424 axon cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:2444989|PANTHER:PTN000342074 9606 Homo sapiens GO_Central Spatacsin 20200129 UniProtKB Q96JI7 SPG11 is_active_in GO:0030425 dendrite cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:2444989|PANTHER:PTN000342074 9606 Homo sapiens GO_Central Spatacsin 20200129 UniProtKB Q96JI7 SPG11 is_active_in GO:0045202 synapse cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:2444989|PANTHER:PTN000342074|UniProtKB:Q96JI7 9606 Homo sapiens GO_Central Spatacsin 20200129 UniProtKB Q96JI7 SPG11 involved_in GO:0048489 synaptic vesicle transport biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000342074|UniProtKB:Q96JI7 9606 Homo sapiens GO_Central Spatacsin 20200129 UniProtKB Q96JI7 SPG11 located_in GO:0005634 nucleus cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0191 9606 Homo sapiens UniProt Spatacsin 20260428 UniProtKB Q96JI7 SPG11 located_in GO:0005829 cytosol cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q3UHA3|ensembl:ENSMUSP00000037543|UniProtKB-SubCell:SL-0091 9606 Homo sapiens UniProt Spatacsin 20260428 UniProtKB Q96JI7 SPG11 located_in GO:0030424 axon cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q3UHA3|ensembl:ENSMUSP00000037543|UniProtKB-SubCell:SL-0279 9606 Homo sapiens UniProt Spatacsin 20260428 UniProtKB Q96JI7 SPG11 located_in GO:0030425 dendrite cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q3UHA3|ensembl:ENSMUSP00000037543|UniProtKB-SubCell:SL-0283 9606 Homo sapiens UniProt Spatacsin 20260428 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23825025 UniProtKB:O43299 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23825025 UniProtKB:Q2VPB7 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23825025 UniProtKB:Q68DK2 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UJW9 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:29949766 UniProtKB:Q05193 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:O43299 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:Q2VPB7 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:36096339 UniProtKB:P27348 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:36096339 UniProtKB:P31946 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:36096339 UniProtKB:P61981 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:36096339 UniProtKB:P62258 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:36096339 UniProtKB:P63104 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:36096339 UniProtKB:Q04917 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:37871017 UniProtKB:Q04917 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:37871017 UniProtKB:Q05193 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:37871017 UniProtKB:Q3U829 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:37871017 UniProtKB:Q68DK2 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:40175557 UniProtKB:Q2VPB7 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:40175557 UniProtKB:Q3U829 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:40175557 UniProtKB:Q68DK2 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:40175557 UniProtKB:Q96JI7 9606 Homo sapiens IntAct Spatacsin 20260425 UniProtKB Q96JI7 SPG11 located_in GO:0005737 cytoplasm cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:A0A0G2JZP7|ensembl:ENSRNOP00000071131 9606 Homo sapiens Ensembl Spatacsin 20260422 UniProtKB Q96JI7 SPG11 is_active_in GO:0005783 endoplasmic reticulum cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q3UHA3|ensembl:ENSMUSP00000037543 9606 Homo sapiens Ensembl Spatacsin 20260422 UniProtKB Q96JI7 SPG11 located_in GO:0045202 synapse cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q3UHA3|ensembl:ENSMUSP00000037543 9606 Homo sapiens Ensembl Spatacsin 20260422 UniProtKB Q96JI7 SPG11 located_in GO:0005730 nucleolus cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Spatacsin 20251115 UniProtKB Q96JI7 SPG11 located_in GO:0005829 cytosol cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Spatacsin 20251115 UniProtKB Q96JI7 SPG11 located_in GO:0005886 plasma membrane cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Spatacsin 20251115 UniProtKB Q96JI7 SPG11 located_in GO:0005634 nucleus cellular_component ECO:0000269 EXP PMID:17322883 9606 Homo sapiens UniProt Spatacsin 20251027 UniProtKB Q96JI7 SPG11 located_in GO:0005764 lysosome cellular_component ECO:0000353 IPI PMID:25365221 9606 Homo sapiens ComplexPortal Spatacsin 20250905 UniProtKB Q96JI7 SPG11 located_in GO:0005770 late endosome cellular_component ECO:0000353 IPI PMID:40175557 9606 Homo sapiens ComplexPortal Spatacsin 20250905 UniProtKB Q96JI7 SPG11 involved_in GO:0097212 lysosomal membrane organization biological_process ECO:0005547 NAS PMID:40175557 9606 Homo sapiens ComplexPortal Spatacsin 20250905 UniProtKB Q96JI7 SPG11 involved_in GO:0097753 membrane bending biological_process ECO:0005547 NAS PMID:40175557 9606 Homo sapiens ComplexPortal Spatacsin 20250905 UniProtKB Q96JI7 SPG11 located_in GO:0005764 lysosome cellular_component ECO:0005547 NAS PMID:40175557 9606 Homo sapiens ComplexPortal Spatacsin 20250828 UniProtKB Q96JI7 SPG11 located_in GO:0005770 late endosome cellular_component ECO:0005547 NAS PMID:40175557 9606 Homo sapiens ComplexPortal Spatacsin 20250828 UniProtKB Q96JI7 SPG11 involved_in GO:0007040 lysosome organization biological_process ECO:0005547 NAS PMID:40175557 9606 Homo sapiens ComplexPortal Spatacsin 20250828 UniProtKB Q96JI7 SPG11 acts_upstream_of_or_within GO:0007040 lysosome organization biological_process ECO:0000314 IDA PMID:25365221 9606 Homo sapiens MGI Spatacsin 20211111 UniProtKB Q96JI7 SPG11 acts_upstream_of_or_within GO:0007040 lysosome organization biological_process ECO:0000315 IMP PMID:25365221 9606 Homo sapiens MGI Spatacsin 20211111 UniProtKB Q96JI7 SPG11 enables GO:0019901 protein kinase binding molecular_function ECO:0000314 IDA PMID:25365221 9606 Homo sapiens MGI Spatacsin 20211111 UniProtKB Q96JI7 SPG11 acts_upstream_of_or_within GO:1905037 autophagosome organization biological_process ECO:0000314 IDA PMID:25365221 9606 Homo sapiens MGI Spatacsin 20211111 UniProtKB Q96JI7 SPG11 acts_upstream_of_or_within GO:0007040 lysosome organization biological_process ECO:0006052 IMP PMID:25365221 9606 Homo sapiens MGI Spatacsin 20211110 UniProtKB Q96JI7 SPG11 acts_upstream_of_or_within GO:1905037 autophagosome organization biological_process ECO:0006052 IMP PMID:25365221 9606 Homo sapiens MGI Spatacsin 20211110 UniProtKB Q96JI7 SPG11 located_in GO:0005829 cytosol cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q3UHA3 9606 Homo sapiens UniProt Spatacsin 20160421 UniProtKB Q96JI7 SPG11 located_in GO:0045202 synapse cellular_component ECO:0000314 IDA PMID:24794856 9606 Homo sapiens UniProt Spatacsin 20160421 UniProtKB Q96JI7 SPG11 involved_in GO:0008088 axo-dendritic transport biological_process ECO:0000315 IMP PMID:24794856 9606 Homo sapiens UniProt Spatacsin 20160413 UniProtKB Q96JI7 SPG11 involved_in GO:0007268 chemical synaptic transmission biological_process ECO:0000315 IMP PMID:24794856 9606 Homo sapiens UniProt Spatacsin 20160412 UniProtKB Q96JI7 SPG11 involved_in GO:0048489 synaptic vesicle transport biological_process ECO:0000315 IMP PMID:24794856 9606 Homo sapiens UniProt Spatacsin 20160412 UniProtKB Q96JI7 SPG11 located_in GO:0005765 lysosomal membrane cellular_component ECO:0007005 HDA PMID:17897319 9606 Homo sapiens UniProt Spatacsin 20130924 UniProtKB Q96JI7 SPG11 located_in GO:0005737 cytoplasm cellular_component ECO:0000314 IDA PMID:21545838 9606 Homo sapiens MGI Spatacsin 20120903 UniProtKB Q96JI7 SPG11 located_in GO:0031410 cytoplasmic vesicle cellular_component ECO:0000314 IDA PMID:21545838 9606 Homo sapiens MGI Spatacsin 20120903 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20613862 UniProtKB:O43299 9606 Homo sapiens UniProt Spatacsin 20110401 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20613862 UniProtKB:Q2VPB7 9606 Homo sapiens UniProt Spatacsin 20110401 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20613862 UniProtKB:Q68DK2 9606 Homo sapiens UniProt Spatacsin 20110401 UniProtKB Q96JI7 SPG11 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20613862 UniProtKB:Q9NUS5 9606 Homo sapiens UniProt Spatacsin 20110401