SRC (proto-oncogene c-Src) is a non-receptor protein tyrosine kinase of 536 residues built from an N-terminal myristoylated SH4/unique region, an SH3 domain, an SH2 domain, a tyrosine kinase domain and a short C-terminal regulatory tail. Myristoylation anchors it to the cytoplasmic face of the plasma membrane and endosomal membranes. Its activity is controlled by two intramolecular clamps: phosphorylation of the tail tyrosine (Tyr530) by CSK lets the SH2 domain bind the tail, and the SH3 domain binds the SH2-kinase linker, holding the kinase inactive; dephosphorylation of the tail (e.g. by PTPRA), or competing SH2/SH3 ligands, release the clamps and allow activation-loop autophosphorylation (Tyr419). The SH2 domain recruits SRC to phosphotyrosine sites on activated receptor tyrosine kinases, FAK/PYK2, PTPRA and other partners, the SH3 domain binds proline-rich motifs, and the C-terminus is a PDZ-binding motif. Once recruited, SRC phosphorylates many substrates at focal adhesions, adherens and gap junctions, podosomes and receptor complexes, transducing signals from integrins, growth factor, cytokine, G protein-coupled and immune receptors to control adhesion turnover, cytoskeletal organisation, migration, survival, proliferation and, in osteoclasts, bone resorption. Src kinases with the same SH3-SH2-kinase architecture and tail phosphorylation by Csk are present in choanoflagellates, unicellular relatives of animals; in those organisms Csk phosphorylation inhibits Src only weakly or partially, and the adhesion-junction and tissue-level roles of SRC are documented only in animals.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000122 negative regulation of transcription by RNA polymerase II | IMP PMID:21531765 High-throughput RNAi screening reveals novel regulators of t... | MARK AS OVER ANNOTATED | Summary: IMP annotation to negative regulation of transcription by RNA polymerase II (GO:0000122) from PMID:21531765. From a kinome-wide RNAi screen for regulators of telomerase activity. Reason: From a kinome-wide RNAi screen for regulators of telomerase activity; any effect of SRC knockdown on TERT transcription is an indirect consequence of signalling. SRC is not a transcriptional repressor, so this process term over-states its role. |
| GO:0002102 podosome | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation to podosome (GO:0002102) from GO_REF:0000107. SRC is required for podosome formation and localises to podosomes and invadopodia, consistent with its role in adhesion-structure turnover (UniProt function text). Reason: SRC is required for podosome formation and localises to podosomes and invadopodia, consistent with its role in adhesion-structure turnover (UniProt function text). Electronic transfer from mouse Src is sound. |
| GO:0002223 stimulatory C-type lectin receptor signaling pathway | TAS Reactome:R-HSA-5621481 | KEEP AS NON CORE | Summary: TAS annotation to stimulatory C-type lectin receptor signaling pathway (GO:0002223) from Reactome:R-HSA-5621481. Reactome places SRC in Dectin/C-type lectin receptor signalling. Reason: Reactome places SRC in Dectin/C-type lectin receptor signalling; SRC-family kinases phosphorylate receptor ITAM/hemITAM motifs. A context-specific pathway rather than a core function of SRC. |
| GO:0002862 negative regulation of inflammatory response to antigenic stimulus | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation to negative regulation of inflammatory response to antigenic stimulus (GO:0002862) from GO_REF:0000117. Immune-context regulatory role inferred by ARBA / Reactome. Reason: Immune-context regulatory role inferred by ARBA / Reactome; SRC-family kinase participation in inhibitory receptor signalling is plausible but cell-type specific and not a core SRC function. |
| GO:0002862 negative regulation of inflammatory response to antigenic stimulus | TAS Reactome:R-HSA-9664323 | KEEP AS NON CORE | Summary: TAS annotation to negative regulation of inflammatory response to antigenic stimulus (GO:0002862) from Reactome:R-HSA-9664323. Immune-context regulatory role inferred by ARBA / Reactome. Reason: Immune-context regulatory role inferred by ARBA / Reactome; SRC-family kinase participation in inhibitory receptor signalling is plausible but cell-type specific and not a core SRC function. |
| GO:0004672 protein kinase activity | IDA PMID:18616680 TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1... | MODIFY | Summary: IDA annotation to protein kinase activity (GO:0004672) from PMID:18616680. SRC is a tyrosine-specific kinase. Reason: SRC is a tyrosine-specific kinase; the measured activity in this paper is tyrosine phosphorylation of the substrate, so the more specific protein tyrosine kinase activity (GO:0004713) is appropriate. Proposed replacements: protein tyrosine kinase activity |
| GO:0004672 protein kinase activity | IDA PMID:25501895 c-Src mediated tyrosine phosphorylation of plakophilin 3 as ... | MODIFY | Summary: IDA annotation to protein kinase activity (GO:0004672) from PMID:25501895. SRC is a tyrosine-specific kinase. Reason: SRC is a tyrosine-specific kinase; the measured activity in this paper is tyrosine phosphorylation of the substrate, so the more specific protein tyrosine kinase activity (GO:0004713) is appropriate. Proposed replacements: protein tyrosine kinase activity |
| GO:0004672 protein kinase activity | IEA GO_REF:0000120 | MODIFY | Summary: IEA annotation to protein kinase activity (GO:0004672) from GO_REF:0000120. Broad electronic protein kinase activity annotation. Reason: Broad electronic protein kinase activity annotation; correct but SRC is tyrosine-specific, so protein tyrosine kinase activity (GO:0004713) is the precise term, consistent with the IDA rows for this term. Proposed replacements: protein tyrosine kinase activity |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:10861086 Differential involvement of Src family kinases in Fc gamma r... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:10861086. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:11448999 Vav2 is required for cell spreading. | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:11448999. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:12923167 Tyrosyl phosphorylation of Shp2 is required for normal ERK a... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:12923167. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:1381360 Steel factor stimulates the tyrosine phosphorylation of the ... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:1381360. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:14632929 Development and characterization of potent and specific pept... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:14632929. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:15735019 Identification of Src-specific phosphorylation site on focal... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:15735019. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:16921024 Differential kinase requirements in human and mouse Fc-gamma... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:16921024. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:17030621 Loss of Hsp90 association up-regulates Src-dependent ErbB2 a... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:17030621. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:18697750 Gab2 is involved in differential phosphoinositide 3-kinase s... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:18697750. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:20100835 Src kinase phosphorylates RUNX3 at tyrosine residues and loc... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:20100835. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:21036157 Heme controls the regulation of protein tyrosine kinases Jak... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:21036157. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:25501895 c-Src mediated tyrosine phosphorylation of plakophilin 3 as ... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:25501895. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:7929427 Cdc2-mediated modulation of pp60c-src activity. | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:7929427. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:8759729 Physical and functional association of Fc mu receptor on hum... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:8759729. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:9571170 Butein, a specific protein tyrosine kinase inhibitor. | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:9571170. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:9799234 Kit signaling through PI 3-kinase and Src kinase pathways: a... | ACCEPT | Summary: EXP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:9799234. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:16441665 Crosstalk between Src and major vault protein in epidermal g... | ACCEPT | Summary: IDA annotation to protein tyrosine kinase activity (GO:0004713) from PMID:16441665. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:19059439 PKCdelta-dependent functional switch of rpS3 between transla... | ACCEPT | Summary: IDA annotation to protein tyrosine kinase activity (GO:0004713) from PMID:19059439. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:19307596 Reversion-induced LIM interaction with Src reveals a novel S... | ACCEPT | Summary: IDA annotation to protein tyrosine kinase activity (GO:0004713) from PMID:19307596. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:34234773 The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling... | ACCEPT | Summary: IDA annotation to protein tyrosine kinase activity (GO:0004713) from PMID:34234773. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:35927303 Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 com... | ACCEPT | Summary: IDA annotation to protein tyrosine kinase activity (GO:0004713) from PMID:35927303. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: IEA annotation to protein tyrosine kinase activity (GO:0004713) from GO_REF:0000120. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:20624904 Tarp regulates early Chlamydia-induced host cell survival th... | ACCEPT | Summary: IMP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:20624904. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:25425738 Lipid raft-associated Ξ²-adducin is required for PSGL-1-media... | ACCEPT | Summary: IMP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:25425738. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:26598555 VE-cadherin facilitates BMP-induced endothelial cell permeab... | ACCEPT | Summary: IMP annotation to protein tyrosine kinase activity (GO:0004713) from PMID:26598555. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation to protein tyrosine kinase activity (GO:0004713) from GO_REF:0000024. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | NAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: NAS annotation to protein tyrosine kinase activity (GO:0004713) from PMID:28386764. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS PMID:9020193 Gbetagamma subunits mediate Src-dependent phosphorylation of... | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from PMID:9020193. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-112333 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-112333. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-1295609 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-1295609. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-1433506 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-1433506. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-1472121 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-1472121. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-177937 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-177937. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-191636 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-191636. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-210291 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-210291. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-354124 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-354124. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-377640 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-377640. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-380780 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-380780. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-388831 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-388831. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-388833 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-388833. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-418163 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-418163. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-429441 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-429441. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-4420121 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-4420121. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-4420128 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-4420128. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-445084 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-445084. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-5607750 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-5607750. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-8874080 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-8874080. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-8876948 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-8876948. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-8948143 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-8948143. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9021609 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-9021609. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9603420 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-9603420. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9664261 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-9664261. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9934751 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-9934751. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9958889 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-9958889. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9958892 | ACCEPT | Summary: TAS annotation to protein tyrosine kinase activity (GO:0004713) from Reactome:R-HSA-9958892. Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors. Reason: Protein tyrosine kinase activity is the defining catalytic activity of SRC (EC 2.7.10.2), demonstrated with many substrates and inhibitors; this row is consistent with that core function. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation to non-membrane spanning protein tyrosine kinase activity (GO:0004715) from GO_REF:0000033. SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase. Reason: SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase; non-membrane spanning protein tyrosine kinase activity is the most precise MF term for its core activity. The activity and the SH3-SH2-kinase architecture are conserved in choanoflagellate Src (PMID:18390552). Supporting Evidence: PMID:18390552 The kinase has the same domain arrangement as mammalian Src kinases, and we find that the individual Src homology 3 (SH3), SH2, and catalytic domains have similar functions to their mammalian counterparts. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:11606584 Tyrosine residues in phospholipase Cgamma 2 essential for th... | ACCEPT | Summary: IDA annotation to non-membrane spanning protein tyrosine kinase activity (GO:0004715) from PMID:11606584. SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase. Reason: SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase; non-membrane spanning protein tyrosine kinase activity is the most precise MF term for its core activity. The activity and the SH3-SH2-kinase architecture are conserved in choanoflagellate Src (PMID:18390552). Supporting Evidence: PMID:18390552 The kinase has the same domain arrangement as mammalian Src kinases, and we find that the individual Src homology 3 (SH3), SH2, and catalytic domains have similar functions to their mammalian counterparts. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:33963050 The Integrin Signaling Network Promotes Axon Regeneration vi... | ACCEPT | Summary: IDA annotation to non-membrane spanning protein tyrosine kinase activity (GO:0004715) from PMID:33963050. SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase. Reason: SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase; non-membrane spanning protein tyrosine kinase activity is the most precise MF term for its core activity. The activity and the SH3-SH2-kinase architecture are conserved in choanoflagellate Src (PMID:18390552). Supporting Evidence: PMID:18390552 The kinase has the same domain arrangement as mammalian Src kinases, and we find that the individual Src homology 3 (SH3), SH2, and catalytic domains have similar functions to their mammalian counterparts. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000003 | ACCEPT | Summary: IEA annotation to non-membrane spanning protein tyrosine kinase activity (GO:0004715) from GO_REF:0000003. SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase. Reason: SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase; non-membrane spanning protein tyrosine kinase activity is the most precise MF term for its core activity. The activity and the SH3-SH2-kinase architecture are conserved in choanoflagellate Src (PMID:18390552). Supporting Evidence: PMID:18390552 The kinase has the same domain arrangement as mammalian Src kinases, and we find that the individual Src homology 3 (SH3), SH2, and catalytic domains have similar functions to their mammalian counterparts. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | NAS PMID:20018849 JNK pathway-associated phosphatase dephosphorylates focal ad... | ACCEPT | Summary: NAS annotation to non-membrane spanning protein tyrosine kinase activity (GO:0004715) from PMID:20018849. SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase. Reason: SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase; non-membrane spanning protein tyrosine kinase activity is the most precise MF term for its core activity. The activity and the SH3-SH2-kinase architecture are conserved in choanoflagellate Src (PMID:18390552). Supporting Evidence: PMID:18390552 The kinase has the same domain arrangement as mammalian Src kinases, and we find that the individual Src homology 3 (SH3), SH2, and catalytic domains have similar functions to their mammalian counterparts. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | TAS PMID:19267251 Cooperation between integrin alphavbeta3 and VEGFR2 in angio... | ACCEPT | Summary: TAS annotation to non-membrane spanning protein tyrosine kinase activity (GO:0004715) from PMID:19267251. SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase. Reason: SRC is a cytoplasmic, membrane-anchored (myristoylated) but non-transmembrane tyrosine kinase; non-membrane spanning protein tyrosine kinase activity is the most precise MF term for its core activity. The activity and the SH3-SH2-kinase architecture are conserved in choanoflagellate Src (PMID:18390552). Supporting Evidence: PMID:18390552 The kinase has the same domain arrangement as mammalian Src kinases, and we find that the individual Src homology 3 (SH3), SH2, and catalytic domains have similar functions to their mammalian counterparts. |
| GO:0005102 signaling receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation to signaling receptor binding (GO:0005102) from GO_REF:0000033. SRC is recruited to and binds many activated cell-surface receptors (RTKs, integrins, cytokine and GPCR complexes) through its SH2 and SH3 domains. Reason: SRC is recruited to and binds many activated cell-surface receptors (RTKs, integrins, cytokine and GPCR complexes) through its SH2 and SH3 domains. The IBA placement over the Src family is phylogenetically reasonable. |
| GO:0005102 signaling receptor binding | IPI PMID:19332538 Density-enhanced phosphatase 1 regulates phosphorylation of ... | ACCEPT | Summary: IPI annotation to signaling receptor binding (GO:0005102) from PMID:19332538. PMID:19332538 concerns the receptor-like phosphatase DEP-1 at tight junctions. Reason: PMID:19332538 concerns the receptor-like phosphatase DEP-1 at tight junctions; SRC associates with this receptor-type phosphatase, one of many cell-surface receptors SRC binds. Consistent with the IBA for this term. |
| GO:0005178 integrin binding | IPI PMID:19141530 Integrin alpha(v)beta(3) is a pleiotrophin receptor required... | ACCEPT | Summary: IPI annotation to integrin binding (GO:0005178) from PMID:19141530. PMID:19141530 shows integrin alphavbeta3-dependent beta3 phosphorylation requiring c-src downstream of pleiotrophin. Reason: PMID:19141530 shows integrin alphavbeta3-dependent beta3 phosphorylation requiring c-src downstream of pleiotrophin; the SRC-integrin association is real (SH3 to beta3 tail) and underlies integrin outside-in signalling. Supporting Evidence: PMID:16115959 One exception is in platelets, in which a constitutive association between integrin Ξ±IIbΞ²3 and c-Src is mediated by direct interaction of the Ξ²3 cytoplasmic domain with the c-Src SH3 domain |
| GO:0005178 integrin binding | TAS PMID:19267251 Cooperation between integrin alphavbeta3 and VEGFR2 in angio... | ACCEPT | Summary: TAS annotation to integrin binding (GO:0005178) from PMID:19267251. SRC binds integrin beta cytoplasmic tails (notably beta3) through its SH3 domain, which underlies integrin outside-in signalling. Reason: SRC binds integrin beta cytoplasmic tails (notably beta3) through its SH3 domain, which underlies integrin outside-in signalling. Supporting Evidence: PMID:16115959 One exception is in platelets, in which a constitutive association between integrin Ξ±IIbΞ²3 and c-Src is mediated by direct interaction of the Ξ²3 cytoplasmic domain with the c-Src SH3 domain |
| GO:0005515 protein binding | IPI PMID:10521452 Negative regulation of PYK2/related adhesion focal tyrosine ... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PTK2B (Q14289) from PMID:10521452. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:10521452 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:10521452 overexpression of wild-type SHPTP1 blocks interaction of RAFTK with the SH2-domain of c-Src |
| GO:0005515 protein binding | IPI PMID:10542110 Simultaneous assay of Src SH3 and SH2 domain binding using d... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and BCAR1 (P56945) from PMID:10542110. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:10542110 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:10698938 A phosphotyrosine displacement mechanism for activation of S... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PTPRA (P18433) from PMID:10698938. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:10698938 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:10698938 We suggest that pTyr789 enables pTyr527 dephosphorylation by a pilot binding with the Src SH2 domain that displaces the intramolecular pTyr527-SH2 binding. |
| GO:0005515 protein binding | IPI PMID:10801826 Platelet-endothelial cell adhesion molecule-1 (CD31), a scaf... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PECAM1 (P16284) from PMID:10801826. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:10801826 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:11007774 Identification of protein-tyrosine phosphatase 1B as the maj... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPN1 (P18031) from PMID:11007774. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:11007774 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). PTP1B is a phosphatase acting on SRC (and SRC phosphorylates PTP1B); the enzyme-substrate relationship is captured by kinase activity terms. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:11149930 Cbl associates with Pyk2 and Src to regulate Src kinase acti... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PTK2B (Q14289) from PMID:11149930. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:11149930 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:11149930 In this complex, autophosphorylated Pyk2 binds to Src's SH2 domain, while Cbl interacts with Src's SH3 domain. |
| GO:0005515 protein binding | IPI PMID:11741929 Phosphorylation-dependent interactions between ADAM15 cytopl... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ADAM15 (Q13444) from PMID:11741929. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:11741929 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:11741929 Dephosphorylation of cell extracts resulted in decreased association of ADAM15 with Src family PTK SH3 domains |
| GO:0005515 protein binding | IPI PMID:11923305 Mitotic activation of protein-tyrosine phosphatase alpha and... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PTPRA (P18433) from PMID:11923305. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:11923305 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:11923305 This involves serine phosphorylation-dependent differential modulation of the affinity of Tyr(P)789 for the Src and Grb2 SH2 domains. |
| GO:0005515 protein binding | IPI PMID:11940572 ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent ma... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ERBB2 (P04626) from PMID:11940572. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:11940572 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:12509223 Src kinase becomes preferentially associated with the VEGFR,... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and KDR (P35968) from PMID:12509223. The cited work defines the binding mode as association with an activated receptor tyrosine kinase. Reason: Generic protein binding is uninformative. PMID:12509223 specifies the interaction mode (association with an activated receptor tyrosine kinase), so the row is replaced by receptor tyrosine kinase binding (GO:0030971). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: receptor tyrosine kinase binding Supporting Evidence: PMID:12509223 The results indicated that VEGF-stimulated KDR/Flk-1 was able to bind strongly to constructs containing both the Src SH3 and SH2 domains |
| GO:0005515 protein binding | IPI PMID:12857726 The tyrosine phosphatase 1B regulates linker for activation ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPN1 (P18031) from PMID:12857726. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:12857726 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). PTP1B is a phosphatase acting on SRC (and SRC phosphorylates PTP1B); the enzyme-substrate relationship is captured by kinase activity terms. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:14963108 Characterization of the interactions of estrogen receptor an... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ESR1 (P03372) from PMID:14963108. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:14963108 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:14963108 ER interacts with Src's SH2 domain using phosphotyrosine 537, and this complex was further stabilized by MNAR-ER interaction. |
| GO:0005515 protein binding | IPI PMID:15143158 Mitochondrial AKAP121 binds and targets protein tyrosine pho... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPN21 (Q16825) from PMID:15143158. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:15143158 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:15546919 ARAP3 is transiently tyrosine phosphorylated in cells attach... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and Arap3 (Q8R5G7) from PMID:15546919. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:15546919 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:15735685 The rat tyrosine phosphatase eta increases cell adhesion by ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and Ptprj (Q62884) from PMID:15735685. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:15735685 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:15749833 Functional role of c-Src in IL-1-induced NF-kappa B activati... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and IKBKG (Q9Y6K9) from PMID:15749833. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:15749833 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:15866871 The role of protein-tyrosine phosphatase 1B in integrin sign... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PTPN1 (P18031) from PMID:15866871. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:15866871 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:15866871 We also show that PTP1B forms a complex with Src and p130(Cas), and that the proline-rich motif PPRPPK (residues 309-314) in PTP1B is essential for the complex formation. |
| GO:0005515 protein binding | IPI PMID:16115959 PTP-1B is an essential positive regulator of platelet integr... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPN1 (P18031) from PMID:16115959. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16115959 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). PTP1B is a phosphatase acting on SRC (and SRC phosphorylates PTP1B); the enzyme-substrate relationship is captured by kinase activity terms. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16169070 A human protein-protein interaction network: a resource for ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and KHDRBS1 (Q07666) from PMID:16169070. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16169070 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16273093 A quantitative protein interaction network for the ErbB rece... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ERBB3 (P21860) from PMID:16273093. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:16273093 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:16273093 Here we use protein microarrays comprising virtually every Src homology 2 (SH2) and phosphotyrosine binding (PTB) domain encoded in the human genome to measure the equilibrium dissociation constant of each domain for 61 peptides representing physiological sites of tyrosine phosphorylation on the four ErbB receptors. |
| GO:0005515 protein binding | IPI PMID:16291744 Phosphorylated alpha-actinin and protein-tyrosine phosphatas... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ACTN1 (P12814) from PMID:16291744. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16291744 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16291744 Phosphorylated alpha-actinin and protein-tyrosine phosphatas... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:16291744. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16291744 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16374509 Identification of preferred protein interactions by phage-di... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PAK2 (Q13177) from PMID:16374509. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:16374509 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:16374509 Studies involving three ligand proteins, human immunodeficiency virus-1 Nef, p21-activated kinase (PAK)2 and ADAM15, showed previously reported as well as novel SH3 partners with nanomolar affinities specific for them. |
| GO:0005515 protein binding | IPI PMID:16374509 Identification of preferred protein interactions by phage-di... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ADAM15 (Q13444) from PMID:16374509. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:16374509 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:16374509 Studies involving three ligand proteins, human immunodeficiency virus-1 Nef, p21-activated kinase (PAK)2 and ADAM15, showed previously reported as well as novel SH3 partners with nanomolar affinities specific for them. |
| GO:0005515 protein binding | IPI PMID:16432186 Role of beta-arrestin 1 in the metastatic progression of col... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ARRB1 (P49407) from PMID:16432186. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16432186 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16479011 The adaptor protein Tom1L1 is a negative regulator of Src mi... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PDGFRB (P09619) from PMID:16479011. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16479011 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16479011 The adaptor protein Tom1L1 is a negative regulator of Src mi... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and TOM1L2 (Q6ZVM7) from PMID:16479011. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16479011 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16511561 Metalloproteinase/Presenilin1 processing of ephrinB regulate... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and Efnb2 (P52800) from PMID:16511561. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16511561 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16537444 Structural characterization of autoinhibited c-Met kinase pr... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPN1 (P18031) from PMID:16537444. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16537444 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). PTP1B is a phosphatase acting on SRC (and SRC phosphorylates PTP1B); the enzyme-substrate relationship is captured by kinase activity terms. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16636290 Targeting AMAP1 and cortactin binding bearing an atypical sr... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and CBL (P22681) from PMID:16636290. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:16636290 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:16636290 the GST-Src SH3 domain and c-Cbl |
| GO:0005515 protein binding | IPI PMID:16636290 Targeting AMAP1 and cortactin binding bearing an atypical sr... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ASAP1 (Q9ULH1) from PMID:16636290. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16636290 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16741966 Ribosomal protein L10 interacts with the SH3 domain and regu... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and RPL10 (P27635) from PMID:16741966. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:16741966 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:16741966 The RP-L10 was associated with the SH3 domains of Src and Yes. |
| GO:0005515 protein binding | IPI PMID:16844778 Hsp90 inhibition transiently activates Src kinase and promot... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and HSP90AA1 (P07900) from PMID:16844778. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16844778 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). HSP90/CDC37 association reflects SRC being a chaperone client kinase, not a SRC molecular function. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16899217 Magicin associates with the Src-family kinases and is phosph... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and MED28 (Q9H204) from PMID:16899217. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16899217 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16964398 EG-1 interacts with c-Src and activates its signaling pathwa... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and MED28 (Q9H204) from PMID:16964398. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16964398 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16966330 Phosphorylation of Tyr1214 within VEGFR-2 triggers the recru... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and FYN (P06241) from PMID:16966330. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16966330 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:16966330 Phosphorylation of Tyr1214 within VEGFR-2 triggers the recru... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:16966330. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:16966330 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17038317 Ack1 mediates Cdc42-dependent cell migration and signaling t... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and BCAR1 (P56945) from PMID:17038317. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17038317 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17043237 An inherent role of microtubule network in the action of nuc... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ESR1 (P03372) from PMID:17043237. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17043237 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17092689 Direct interaction between ER membrane-bound PTP1B and its p... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPN1 (P18031) from PMID:17092689. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17092689 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). PTP1B is a phosphatase acting on SRC (and SRC phosphorylates PTP1B); the enzyme-substrate relationship is captured by kinase activity terms. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17094785 Identification and functional characterization of an Src hom... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and CBL (P22681) from PMID:17094785. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:17094785 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:17094785 We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl. |
| GO:0005515 protein binding | IPI PMID:17141222 PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CBL (P22681) from PMID:17141222. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17141222 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17170700 Dosage-dependent switch from G protein-coupled to G protein-... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ADRB2 (P07550) from PMID:17170700. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17170700 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17178840 Deciphering the cross talk between hnRNP K and c-Src: the c-... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and HNRNPK (P61978) from PMID:17178840. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:17178840 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:17178840 It has been shown earlier that the isolated proline-rich motifs of hnRNP K interact with the isolated SH3 domain of the Src kinase family members c-Src, Lyn, and Fyn in vitro |
| GO:0005515 protein binding | IPI PMID:17284441 Epidermal growth factor directs sex-specific steroid signali... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and EGFR (P00533) from PMID:17284441. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17284441 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17284441 Epidermal growth factor directs sex-specific steroid signali... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ESR1 (P03372) from PMID:17284441. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17284441 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ABL1 (P00519) from PMID:17318191. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17318191 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17412687 XB130, a novel adaptor protein for signal transduction. | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and AFAP1L2 (Q8N4X5) from PMID:17412687. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17412687 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ABL1 (P00519) from PMID:17474147. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:17474147 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:17474147 A group of 12 Src homology (SH) 3 domains from eight human proteins (Swiss-Prot ID: SRC, PLCG1, P85A, NCK1, GRB2, FYN, CRK) were used to screen a peptide target array composed of 1536 potential ligands |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ABL2 (P42684) from PMID:17474147. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:17474147 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:17474147 A group of 12 Src homology (SH) 3 domains from eight human proteins (Swiss-Prot ID: SRC, PLCG1, P85A, NCK1, GRB2, FYN, CRK) were used to screen a peptide target array composed of 1536 potential ligands |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and RAPGEF1 (Q13905) from PMID:17474147. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:17474147 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:17474147 A group of 12 Src homology (SH) 3 domains from eight human proteins (Swiss-Prot ID: SRC, PLCG1, P85A, NCK1, GRB2, FYN, CRK) were used to screen a peptide target array composed of 1536 potential ligands |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ASAP1 (Q9ULH1) from PMID:17474147. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:17474147 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:17474147 A group of 12 Src homology (SH) 3 domains from eight human proteins (Swiss-Prot ID: SRC, PLCG1, P85A, NCK1, GRB2, FYN, CRK) were used to screen a peptide target array composed of 1536 potential ligands |
| GO:0005515 protein binding | IPI PMID:17491594 Regulation of c-Src by binding to the PDZ domain of AF-6. | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and AFDN (P55196) from PMID:17491594. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:17491594 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17491594 We describe the C-terminus of c-Src as a ligand for a PDZ (postsynaptic density 95, PSD-95; discs large, Dlg; zonula occludens-1, ZO-1) domain. |
| GO:0005515 protein binding | IPI PMID:17525734 p140Cap protein suppresses tumour cell properties, regulatin... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:17525734. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17525734 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:17525734 p140Cap protein suppresses tumour cell properties, regulatin... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and SRCIN1 (Q9C0H9) from PMID:17525734. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:17525734 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:17525734 indicating that p140Cap and Src directly interact through the binding of the Src SH3 domain with the most carboxy-terminal proline-rich region of p140Cap |
| GO:0005515 protein binding | IPI PMID:17921256 Variant estrogen receptor-c-Src molecular interdependence an... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ESR1 (P03372) from PMID:17921256. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:17921256 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:17921256 c-Src kinase can phosphorylate ERΞ± at Y537 in resting cells, and, in turn, the c-Src SH2 domain can directly bind to ERΞ± phospho-Y537 |
| GO:0005515 protein binding | IPI PMID:17936276 c-Src is a PDZ interaction partner and substrate of the E3 u... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and LNX1 (Q8TBB1) from PMID:17936276. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:17936276 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17936276 We demonstrate that the interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src. |
| GO:0005515 protein binding | IPI PMID:17974954 PTP1B contributes to the oncogenic properties of colon cance... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPN1 (P18031) from PMID:17974954. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:17974954 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). PTP1B is a phosphatase acting on SRC (and SRC phosphorylates PTP1B); the enzyme-substrate relationship is captured by kinase activity terms. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:18070987 Oncogenic association of the Cbp/PAG adaptor protein with th... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and LYN (P07948) from PMID:18070987. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:18070987 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:18155796 Small proline-rich proteins (SPRR) function as SH3 domain li... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and SPRR2A (P35326) from PMID:18155796. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:18155796 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:18155796 Molecular studies show that non-coordinate BEC expression makes SPRR2A available for binding to SH3 domain-containing proteins |
| GO:0005515 protein binding | IPI PMID:18273061 Structural basis for a novel intrapeptidyl H-bond and revers... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CBL (P22681) from PMID:18273061. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:18273061 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:18328427 Yes and PI3K bind CD95 to signal invasion of glioblastoma. | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and FAS (P25445) from PMID:18328427. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:18328427 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:18377662 Src homology 2 (SH2) domain containing protein tyrosine phos... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and KDR (P35968) from PMID:18377662. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:18377662 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:18464795 FAK-MAPK-dependent adhesion disassembly downstream of L1 con... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and Ptk2 (P34152) from PMID:18464795. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:18464795 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:18662404 The neurotransmitter dopamine modulates vascular permeabilit... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and KDR (P35968) from PMID:18662404. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:18662404 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:18832467 mda-9/Syntenin promotes metastasis in human melanoma cells b... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and SDCBP (O00560) from PMID:18832467. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:18832467 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:18832467 We presently show that mda -9/syntenin interacts with c-Src through its PDZ domain |
| GO:0005515 protein binding | IPI PMID:19059439 PKCdelta-dependent functional switch of rpS3 between transla... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PRKCD (Q05655) from PMID:19059439. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19059439 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19122674 Deficiency of a beta-arrestin-2 signal complex contributes t... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ARRB2 (P32121) from PMID:19122674. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19122674 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19202075 Beta-arrestin links endothelin A receptor to beta-catenin si... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ARRB2 (P32121) from PMID:19202075. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19202075 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19202075 Beta-arrestin links endothelin A receptor to beta-catenin si... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ARRB1 (P49407) from PMID:19202075. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19202075 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19262695 c-Src regulates Akt signaling in response to ghrelin via bet... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and AKT1 (P31749) from PMID:19262695. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:19262695 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:19262695 Akt is phosphorylated at Y by the membrane bound Src via the interaction between its C-terminal proline-rich motif and the SH3 domain of Src. |
| GO:0005515 protein binding | IPI PMID:19307596 Reversion-induced LIM interaction with Src reveals a novel S... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PDLIM4 (P50479) from PMID:19307596. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19307596 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19372587 ErbB2-mediated Src and signal transducer and activator of tr... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ERBB2 (P04626) from PMID:19372587. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19372587 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19419966 The tyrosine kinase c-Src enhances RIG-I (retinoic acid-indu... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and RIGI (O95786) from PMID:19419966. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19419966 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19419966 The tyrosine kinase c-Src enhances RIG-I (retinoic acid-indu... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and TRAF3 (Q13114) from PMID:19419966. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19419966 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19419966 The tyrosine kinase c-Src enhances RIG-I (retinoic acid-indu... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and MAVS (Q7Z434) from PMID:19419966. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19419966 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19419966 The tyrosine kinase c-Src enhances RIG-I (retinoic acid-indu... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and TBK1 (Q9UHD2) from PMID:19419966. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19419966 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19661922 Beta-arrestin1 phosphorylation by GRK5 regulates G protein-i... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and Htr4 (P97288) from PMID:19661922. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19661922 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19665017 The PDZ protein MPP2 interacts with c-Src in epithelial cell... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and MPP2 (Q14168) from PMID:19665017. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:19665017 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:19665017 By PDZ domain array screen, we identified the interaction of c-Src with the PDZ protein Membrane Protein Palmitoylated 2 (MPP2) |
| GO:0005515 protein binding | IPI PMID:19732724 The Tensin-3 protein, including its SH2 domain, is phosphory... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and TNS3 (Q68CZ2) from PMID:19732724. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19732724 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19903481 Involvement of Src tyrosine kinase in Escherichia coli invas... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PIK3R1 (P27986) from PMID:19903481. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19903481 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:19910644 Leptin enhances the potency of circulating angiogenic cells ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ITGB5 (P18084), LEPR (P48357) from PMID:19910644. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:19910644 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:20100835 Src kinase phosphorylates RUNX3 at tyrosine residues and loc... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and RUNX3 (Q13761) from PMID:20100835. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:20100835 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:20158519 Catalytically active membrane-distal phosphatase domain of r... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and Ptpra (P18052) from PMID:20158519. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:20158519 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:20624308 EGFR/Met association regulates EGFR TKI resistance in breast... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and EGFR (P00533) from PMID:20624308. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:20624308 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:20624308 EGFR/Met association regulates EGFR TKI resistance in breast... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and MET (P08581) from PMID:20624308. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:20624308 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:20935677 A positive feedback loop of ER-Ξ±36/EGFR promotes malignant g... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and EGFR (P00533) from PMID:20935677. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:20935677 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:20935677 A positive feedback loop of ER-Ξ±36/EGFR promotes malignant g... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ESR1 (P03372) from PMID:20935677. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:20935677 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21034468 Cyanidin-3-glucoside inhibits ethanol-induced invasion of br... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and BCAR1 (P56945) from PMID:21034468. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21034468 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21034468 Cyanidin-3-glucoside inhibits ethanol-induced invasion of br... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:21034468. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21034468 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21075308 Recombinant human erythropoietin antagonizes trastuzumab tre... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ERBB2 (P04626) from PMID:21075308. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21075308 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21075308 Recombinant human erythropoietin antagonizes trastuzumab tre... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CSNK2A1 (P68400) from PMID:21075308. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21075308 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21233420 VHL loss in renal cell carcinoma leads to up-regulation of C... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CDCP1 (Q9H5V8) from PMID:21233420. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21233420 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21278788 Translationally controlled tumor protein induces human breas... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and EGFR (P00533) from PMID:21278788. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21278788 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21460222 PRR7 is a transmembrane adaptor protein expressed in activat... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PRR7 (Q8TB68) from PMID:21460222. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21460222 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21685945 Rack1 promotes epithelial cell-cell adhesion by regulating E... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CDH1 (P12830) from PMID:21685945. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21685945 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:21725358 The SRC-associated protein CUB Domain-Containing Protein-1 r... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CDCP1 (Q9H5V8) from PMID:21725358. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:21725358 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:22056988 Nuclear PKM2 regulates Ξ²-catenin transactivation upon EGFR a... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CTNNB1 (P35222) from PMID:22056988. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:22056988 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:22402981 Integrin/Fak/Src-mediated regulation of cell survival and an... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:22402981. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:22402981 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:22402981 Integrin/Fak/Src-mediated regulation of cell survival and an... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PIK3R3 (Q92569) from PMID:22402981. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:22402981 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:22439932 NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ROR1 (Q01973) from PMID:22439932. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:22439932 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:22581261 DOCK8 functions as an adaptor that links TLR-MyD88 signaling... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and LYN (P07948) from PMID:22581261. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:22581261 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:23065768 Activation of rapid oestrogen signalling in aggressive human... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ESR1 (P03372) from PMID:23065768. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:23065768 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:23065768 a six-amino acid peptide (pYpep) that mimics the sequence around the phosphotyrosine residue in position 537 of the human ERΞ± disrupts ERΞ±/Src interaction |
| GO:0005515 protein binding | IPI PMID:23065768 Activation of rapid oestrogen signalling in aggressive human... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PIK3R1 (P27986) from PMID:23065768. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:23065768 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:23065768 Activation of rapid oestrogen signalling in aggressive human... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:23065768. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:23065768 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:23397142 Analysis of protein-protein interactions in cross-talk pathw... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PIK3R1 (P27986) from PMID:23397142. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:23397142 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:23564345 Molecular chaperone TRAP1 regulates a metabolic switch betwe... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and TRAP1 (Q12931) from PMID:23564345. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:23564345 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:23585225 LPS induces pp60c-src-mediated tyrosine phosphorylation of H... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and HSP90AB1 (P08238) from PMID:23585225. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:23585225 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). HSP90/CDC37 association reflects SRC being a chaperone client kinase (and HSP90 being a SRC substrate), not a SRC molecular function. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:23954233 Cysteine mutations cause defective tyrosine phosphorylation ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and FBH1 (Q8NFZ0) from PMID:23954233. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:23954233 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:24034250 EGFR-mediated Beclin 1 phosphorylation in autophagy suppress... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and MET (P08581) from PMID:24034250. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:24034250 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:24498420 JMJD6 regulates ERΞ± methylation on arginine. | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ESR1 (P03372) from PMID:24498420. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:24498420 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:24498420 JMJD6 regulates ERΞ± methylation on arginine. | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PIK3R1 (P27986) from PMID:24498420. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:24498420 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and EGFR (P00533) from PMID:24658140. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:24658140 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and MET (P08581) from PMID:24728074. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:24728074 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and AR (P10275) from PMID:24728074. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:24728074 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and KIT (P10721) from PMID:24728074. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:24728074 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and GAB1 (Q13480) from PMID:24728074. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:24728074 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. |
| GO:0005515 protein binding | IPI PMID:25036101 Identification of SH3 domain proteins interacting with the c... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ADAM10 (O14672) from PMID:25036101. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:25036101 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:25036101 In addition, most ADAM proteases contain one or more proline-rich stretches, that potentially enable interactions with Src homology 3 (SH3) domain-containing signaling molecules. |
| GO:0005515 protein binding | IPI PMID:25117710 Phosphorylation of ETS1 by Src family kinases prevents its r... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ETS1 (P14921) from PMID:25117710. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:25117710 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PIK3R1 (P27986) from PMID:25241761. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:25241761 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:25241761. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:25241761 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:25425738 Lipid raft-associated Ξ²-adducin is required for PSGL-1-media... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ADD2 (P35612) from PMID:25425738. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:25425738 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and IL6ST (P40189), YAP1 (P46937) from PMID:25731159. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:25731159 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. The row also lists YAP1, which is a SRC substrate in this paper rather than a defined binding mode. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:25731159 Deletion of gp130 AA 812-827, which contain a phosphotyrosine motif, reduced binding to Src and attenuated activation of Src, YAP and Notch, but not STAT3 |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:25814554. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:25814554 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PIK3R3 (Q92569) from PMID:25814554. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:25814554 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:25825872 Preferred SH3 domain partners of ADAM metalloproteases inclu... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ADAM12 (O43184) from PMID:25825872. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:25825872 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:25825872 For example binding of the SH3 domain of Src tyrosine kinases or p85Ξ± to ADAM12 activates PI3K signaling |
| GO:0005515 protein binding | IPI PMID:25825872 Preferred SH3 domain partners of ADAM metalloproteases inclu... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and ADAM15 (Q13444) from PMID:25825872. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:25825872 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:25825872 Likewise, SH3-mediated interactions of ADAM15 with Src promote Src/FAK signaling |
| GO:0005515 protein binding | IPI PMID:28054552 c-Src phosphorylation and activation of hexokinase promotes ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and HK1 (P19367) from PMID:28054552. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:28054552 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:28065597 A Global Analysis of the Receptor Tyrosine Kinase-Protein Ph... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and EGFR (P00533) from PMID:28065597. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:28065597 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and EGFR (P00533) from PMID:31980649. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:31980649 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and FYN (P06241) from PMID:31980649. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:31980649 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and HSP90AA1 (P07900) from PMID:31980649. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:31980649 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). HSP90/CDC37 association reflects SRC being a chaperone client kinase, not a SRC molecular function. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CSNK2A1 (P68400) from PMID:31980649. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:31980649 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CDC37 (Q16543) from PMID:31980649. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:31980649 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). HSP90/CDC37 association reflects SRC being a chaperone client kinase, not a SRC molecular function. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CDCP1 (Q9H5V8) from PMID:31980649. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:31980649 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and HSP90AA1 (P07900) from PMID:32707033. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32707033 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). HSP90/CDC37 association reflects SRC being a chaperone client kinase, not a SRC molecular function. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and LYN (P07948) from PMID:32707033. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32707033 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CDC37 (Q16543) from PMID:32707033. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32707033 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). HSP90/CDC37 association reflects SRC being a chaperone client kinase, not a SRC molecular function. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and SH2D1B (O14796) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and SH2D1A (O60880) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PIK3R1 (P27986) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTK2 (Q05397) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). FAK-SRC association is real and central to integrin signalling, but this row does not itself define the binding mode; where the mode is defined (SH2 to FAK/PYK2 phosphotyrosine) other rows carry the MODIFY. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and GRB10 (Q13322) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and TNFAIP1 (Q13829) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and BECN1 (Q14457) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and LPIN1 (Q14693) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and RAB11B (Q15907) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ASCL4 (Q6XD76) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and KLF15 (Q9UIH9) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and ZNF232 (Q9UNY5) from PMID:32814053. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:32814053 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and FYN (P06241) from PMID:33961781. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:33961781 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPRA (P18433) from PMID:33961781. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:33961781 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CDC37 (Q16543) from PMID:33961781. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:33961781 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). HSP90/CDC37 association reflects SRC being a chaperone client kinase, not a SRC molecular function. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:35405500 Regulation of growth, invasion and metabolism of breast duct... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and MET (P08581) from PMID:35405500. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:35405500 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and EGFR (P00533) from PMID:35512704. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:35512704 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and GRID2IP (A4D2P6) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and LDB3 (O75112) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and MPDZ (O75970) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and DLG4 (P78352) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and TJP1 (Q07157) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and DLG1 (Q12959) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and IL16 (Q14005) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and DLG2 (Q15700) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PDZK1 (Q5T2W1) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and FRMPD2 (Q68DX3) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and MAGI2 (Q86UL8) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and NHERF4 (Q86UT5) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and LNX2 (Q8N448) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PATJ (Q8NI35) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and LNX1 (Q8TBB1) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and DLG3 (Q92796) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and MAGI1 (Q96QZ7) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and APBA2 (Q99767) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and GRIP2 (Q9C0E4) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and WHRN (Q9P202) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and GRIP1 (Q9Y3R0) from PMID:36115835. The cited work defines the binding mode as binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner. Reason: Generic protein binding is uninformative. PMID:36115835 specifies the interaction mode (binding of the SRC C-terminal PDZ-binding motif to a PDZ domain of the partner), so the row is replaced by PDZ domain binding (GO:0030165). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. This is a proteome-scale holdup/fragmentomics screen of PDZ domains against PDZ-binding-motif peptides; the SRC C-terminus is a known PDZ ligand (PMID:17491594, PMID:17936276). Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 Here we measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs |
| GO:0005515 protein binding | IPI PMID:39009827 Proteome-scale characterisation of motif-based interactome r... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and LDB3 (O75112) from PMID:39009827. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:39009827 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:7478590 Association of pp60c-src with biliary glycoprotein (CD66a), ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and CEACAM1 (P13688) from PMID:7478590. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:7478590 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:7537265 Functional interaction between c-Src and its mitotic target,... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and KHDRBS1 (Q07666) from PMID:7537265. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner and SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:7537265 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner and SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784) and proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding proline-rich region binding Supporting Evidence: PMID:7537265 The results suggest that the selection of Sam 68 as a mitotic target by c-Src is the result of highly specific interaction with SH2 and SH3 domains |
| GO:0005515 protein binding | IPI PMID:8070403 A novel signaling molecule, p130, forms stable complexes in ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and BCAR1 (Q6P5Z4) from PMID:8070403. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:8070403 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:8681387 Crystal structure of the conserved core of HIV-1 Nef complex... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and nef (P03406) from PMID:8681387. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:8681387 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. The crystal structure in the abstract uses an Src-family (Fyn) SH3 domain; the curator recorded the interaction for SRC and the SH3-PxxP mode is shared, so the binding mode, not the partner, is what changes. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:8681387 The conserved PxxP sequence motif of Nef, known to be important for optimal viral replication, is part of a polyproline type II helix that engages the SH3 domain |
| GO:0005515 protein binding | IPI PMID:8849729 A role for Pyk2 and Src in linking G-protein-coupled recepto... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PTK2B (Q14289) from PMID:8849729. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:8849729 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:8849729 Moreover, tyrosine phosphorylation of Pyk2 leads to binding of the SH2 domain of Src to tyrosine 402 of Pyk2 and activation of Src. |
| GO:0005515 protein binding | IPI PMID:9148935 Focal adhesion kinase overexpression enhances ras-dependent ... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and Ptk2 (P34152) from PMID:9148935. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:9148935 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:9162084 Platelet endothelial cell adhesion molecule-1 is phosphoryla... | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and PECAM1 (P16284) from PMID:9162084. The cited work defines the binding mode as SH2-domain binding to a phosphotyrosine on the partner. Reason: Generic protein binding is uninformative. PMID:9162084 specifies the interaction mode (SH2-domain binding to a phosphotyrosine on the partner), so the row is replaced by phosphotyrosine residue binding (GO:0001784). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:9162084 This association appears to be mediated by Src-SH2 domain, because PECAM-1 can be precipitated by a GST-Src-SH2 affinity matrix. |
| GO:0005515 protein binding | IPI PMID:9600099 Multiple phosphorylation of chicken protein tyrosine phospha... | REMOVE | Summary: IPI protein binding (GO:0005515) between SRC and PTPN1 (P18031) from PMID:9600099. The cached text reports the association but does not define a SRC-side binding mode for this partner. Reason: Generic protein binding is uninformative about molecular function and, for this partner, PMID:9600099 does not establish a more specific SRC activity (e.g. SH2-phosphotyrosine, SH3-proline or PDZ binding). PTP1B is a phosphatase acting on SRC (and SRC phosphorylates PTP1B); the enzyme-substrate relationship is captured by kinase activity terms. REMOVE does not mean the reported interaction is false; it means GO:0005515 conveys no function. |
| GO:0005515 protein binding | IPI PMID:9763511 Tau interacts with src-family non-receptor tyrosine kinases. | MODIFY | Summary: IPI protein binding (GO:0005515) between SRC and MAPT (P10636) from PMID:9763511. The cited work defines the binding mode as SH3-domain binding to a proline-rich (PxxP) motif on the partner. Reason: Generic protein binding is uninformative. PMID:9763511 specifies the interaction mode (SH3-domain binding to a proline-rich (PxxP) motif on the partner), so the row is replaced by proline-rich region binding (GO:0070064). The replacement records the SRC-side binding activity that recruits SRC to, or is engaged by, this partner. Proposed replacements: proline-rich region binding Supporting Evidence: PMID:9763511 Here we report that a proline rich sequence in the amino terminus of tau interacts with the SH3 domains of fyn and src non-receptor tyrosine kinases. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: IEA annotation to ATP binding (GO:0005524) from GO_REF:0000002. ATP is the phosphate donor for the kinase reaction. Reason: ATP is the phosphate donor for the kinase reaction; the InterPro-based ATP binding annotation is correct. |
| GO:0005634 nucleus | EXP PMID:7853507 Highly specific antibody to Rous sarcoma virus src gene prod... | KEEP AS NON CORE | Summary: EXP annotation to nucleus (GO:0005634) from PMID:7853507. Reports of nuclear/nucleolar SRC immunoreactivity exist, but SRC acts predominantly at membranes. Reason: Reports of nuclear/nucleolar SRC immunoreactivity exist, but SRC acts predominantly at membranes; nuclear localisation is minor and context dependent. |
| GO:0005634 nucleus | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: IEA annotation to nucleus (GO:0005634) from GO_REF:0000120. Reports of nuclear/nucleolar SRC immunoreactivity exist, but SRC acts predominantly at membranes. Reason: Reports of nuclear/nucleolar SRC immunoreactivity exist, but SRC acts predominantly at membranes; nuclear localisation is minor and context dependent. |
| GO:0005737 cytoplasm | IDA PMID:16441665 Crosstalk between Src and major vault protein in epidermal g... | ACCEPT | Summary: IDA annotation to cytoplasm (GO:0005737) from PMID:16441665. SRC is a cytoplasmic protein (largely on the cytoplasmic face of membranes). Reason: SRC is a cytoplasmic protein (largely on the cytoplasmic face of membranes); cytoplasm is correct at a general level. |
| GO:0005737 cytoplasm | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation to cytoplasm (GO:0005737) from GO_REF:0000107. SRC is a cytoplasmic protein (largely on the cytoplasmic face of membranes). Reason: SRC is a cytoplasmic protein (largely on the cytoplasmic face of membranes); cytoplasm is correct at a general level. |
| GO:0005739 mitochondrion | IDA PMID:19767770 A novel pro-apoptotic function of RACK1: suppression of Src ... | KEEP AS NON CORE | Summary: IDA annotation to mitochondrion (GO:0005739) from PMID:19767770. A pool of c-Src is present in mitochondria where it phosphorylates cytochrome c oxidase (PMID:12615910). Reason: A pool of c-Src is present in mitochondria where it phosphorylates cytochrome c oxidase (PMID:12615910); a real but minor localisation. Supporting Evidence: PMID:12615910 Here, we show that c-Src is also present within mitochondria, where it phosphorylates cytochrome c oxidase (Cox). |
| GO:0005739 mitochondrion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to mitochondrion (GO:0005739) from GO_REF:0000107. A pool of c-Src is present in mitochondria where it phosphorylates cytochrome c oxidase (PMID:12615910). Reason: A pool of c-Src is present in mitochondria where it phosphorylates cytochrome c oxidase (PMID:12615910); a real but minor localisation. Supporting Evidence: PMID:12615910 Here, we show that c-Src is also present within mitochondria, where it phosphorylates cytochrome c oxidase (Cox). |
| GO:0005743 mitochondrial inner membrane | IDA PMID:12615910 Regulation of cytochrome c oxidase activity by c-Src in oste... | KEEP AS NON CORE | Summary: IDA annotation to mitochondrial inner membrane (GO:0005743) from PMID:12615910. Mitochondrial c-Src phosphorylates cytochrome c oxidase. Reason: Mitochondrial c-Src phosphorylates cytochrome c oxidase; inner-membrane association is supported but represents a minor pool. Supporting Evidence: PMID:12615910 Here, we show that c-Src is also present within mitochondria, where it phosphorylates cytochrome c oxidase (Cox). |
| GO:0005743 mitochondrial inner membrane | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: IEA annotation to mitochondrial inner membrane (GO:0005743) from GO_REF:0000120. Mitochondrial c-Src phosphorylates cytochrome c oxidase. Reason: Mitochondrial c-Src phosphorylates cytochrome c oxidase; inner-membrane association is supported but represents a minor pool. Supporting Evidence: PMID:12615910 Here, we show that c-Src is also present within mitochondria, where it phosphorylates cytochrome c oxidase (Cox). |
| GO:0005764 lysosome | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | KEEP AS NON CORE | Summary: IDA annotation to lysosome (GO:0005764) from PMID:20605918. SRC traffics through endosomal/lysosomal membranes (inactive SRC is on endosomal membranes. Reason: SRC traffics through endosomal/lysosomal membranes (inactive SRC is on endosomal membranes; PMID:7525268). Minor localisation. Supporting Evidence: PMID:7525268 Mutation of this tyrosine dramatically redistributes c-Src from endosomal membranes to focal adhesions. |
| GO:0005770 late endosome | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | KEEP AS NON CORE | Summary: IDA annotation to late endosome (GO:0005770) from PMID:20605918. SRC traffics through late endosomal membranes before reaching the plasma membrane. Reason: SRC traffics through late endosomal membranes before reaching the plasma membrane; inactive c-Src resides on endosomal membranes (PMID:7525268). Minor localisation. Supporting Evidence: PMID:7525268 Mutation of this tyrosine dramatically redistributes c-Src from endosomal membranes to focal adhesions. |
| GO:0005829 cytosol | IDA PMID:19767770 A novel pro-apoptotic function of RACK1: suppression of Src ... | ACCEPT | Summary: IDA annotation to cytosol (GO:0005829) from PMID:19767770. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | IEA GO_REF:0000117 | ACCEPT | Summary: IEA annotation to cytosol (GO:0005829) from GO_REF:0000117. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433418 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433418. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433428 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433428. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433451 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433451. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433454 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433454. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433456 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433456. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433488 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433488. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433506 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433506. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433514 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433514. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433542 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1433542. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470009 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1470009. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470010 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1470010. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470012 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1470012. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1472121 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1472121. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1562641 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-1562641. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-191654 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-191654. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2029459 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-2029459. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205234 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-205234. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205238 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-205238. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205244 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-205244. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205319 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-205319. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-210291 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-210291. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-377640 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-377640. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388829 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-388829. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388831 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-388831. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388833 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-388833. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928604 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928604. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928607 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928607. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928614 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928614. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928615 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928615. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928625 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928625. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928627 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928627. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928628 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928628. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928631 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928631. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928633 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928633. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928639 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928639. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928640 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928640. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928641 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928641. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928642 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928642. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928645 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928645. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3928651 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-3928651. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4093327 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-4093327. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4093336 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-4093336. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-418158 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-418158. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-418163 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-418163. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-418170 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-418170. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-418176 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-418176. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-418200 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-418200. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-418662 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-418662. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4420121 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-4420121. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4420128 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-4420128. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4420140 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-4420140. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4420206 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-4420206. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-443418 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-443418. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-443439 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-443439. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-445084 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-445084. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218640 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218640. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218643 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218643. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218645 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218645. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218809 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218809. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218811 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218811. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218819 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218819. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218820 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218820. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218822 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218822. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218826 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218826. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218830 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218830. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218838 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218838. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218839 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218839. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218851 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5218851. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357429 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5357429. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357432 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5357432. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357479 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5357479. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5666104 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-5666104. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8855747 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-8855747. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8948143 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-8948143. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8964242 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-8964242. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8964252 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-8964252. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8964278 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-8964278. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8964287 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-8964287. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8964329 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-8964329. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664261 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9664261. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664275 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9664275. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670412 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9670412. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670413 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9670413. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670414 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9670414. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670416 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9670416. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670417 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9670417. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670418 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9670418. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670426 | ACCEPT | Summary: TAS annotation to cytosol (GO:0005829) from Reactome:R-HSA-9670426. Reactome places SRC in the cytosol for many reactions. Reason: Reactome places SRC in the cytosol for many reactions; SRC is a peripheral protein on the cytoplasmic side of membranes and a soluble pool exists, so cytosol is acceptable. |
| GO:0005856 cytoskeleton | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: IEA annotation to cytoskeleton (GO:0005856) from GO_REF:0000120. SRC associates with actin-based structures (focal adhesions, podosomes, stress fibres) via adaptors such as AFAP1 and cortactin. Reason: SRC associates with actin-based structures (focal adhesions, podosomes, stress fibres) via adaptors such as AFAP1 and cortactin; a general cytoskeleton term is acceptable but not core. |
| GO:0005884 actin filament | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to actin filament (GO:0005884) from GO_REF:0000107. SRC is localised to actin filaments via AFAP1 binding (UniProt). Reason: SRC is localised to actin filaments via AFAP1 binding (UniProt); an indirect, adaptor-dependent association. |
| GO:0005886 plasma membrane | EXP PMID:7525268 Association of the amino-terminal half of c-Src with focal a... | ACCEPT | Summary: EXP annotation to plasma membrane (GO:0005886) from PMID:7525268. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation to plasma membrane (GO:0005886) from GO_REF:0000033. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | ACCEPT | Summary: IDA annotation to plasma membrane (GO:0005886) from GO_REF:0000052. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | IDA PMID:20605918 The Lyn kinase C-lobe mediates Golgi export of Lyn through c... | ACCEPT | Summary: IDA annotation to plasma membrane (GO:0005886) from PMID:20605918. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: IEA annotation to plasma membrane (GO:0005886) from GO_REF:0000120. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-112333 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-112333. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1295609 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-1295609. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-177923 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-177923. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-177937 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-177937. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-186819 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-186819. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-191636 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-191636. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-191654 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-191654. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-191656 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-191656. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1963586 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-1963586. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-2316434. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-2400009. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-354066 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-354066. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-354073 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-354073. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-354077 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-354077. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-354087 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-354087. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-354124 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-354124. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-354149 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-354149. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-354165 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-354165. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-372693 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-372693. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-372697 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-372697. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-372705 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-372705. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-373716 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-373716. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-374701 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-374701. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-377640 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-377640. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-377641 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-377641. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-377643 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-377643. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-377644 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-377644. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-380780 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-380780. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-418850 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-418850. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-418856 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-418856. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-418858 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-418858. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-418868 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-418868. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-418874 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-418874. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-429415 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-429415. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-429441 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-429441. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-432096 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-432096. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-443905 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-443905. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-443910 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-443910. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5607750 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-5607750. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8874080 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-8874080. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8874082 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-8874082. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8874083 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-8874083. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8876948 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-8876948. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8937792 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-8937792. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8937807 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-8937807. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9021596 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9021596. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9021609 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9021609. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9021660 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9021660. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9603419 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9603419. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9603420 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9603420. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9612219 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9612219. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9632412 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9632412. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9934751 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9934751. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9958889 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9958889. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9958892 | ACCEPT | Summary: TAS annotation to plasma membrane (GO:0005886) from Reactome:R-HSA-9958892. SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors. Reason: SRC is anchored to the cytoplasmic face of the plasma membrane by N-myristoylation and is activated there by receptors; plasma membrane is a core location. |
| GO:0005901 caveola | IDA PMID:17848177 Tissue factor induction by protease-activated receptor 1 req... | KEEP AS NON CORE | Summary: IDA annotation to caveola (GO:0005901) from PMID:17848177. SRC is found in caveolae and phosphorylates caveolin-1 (Tyr14). Reason: SRC is found in caveolae and phosphorylates caveolin-1 (Tyr14); a real but context-specific localisation. |
| GO:0005901 caveola | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: IEA annotation to caveola (GO:0005901) from GO_REF:0000120. SRC is found in caveolae and phosphorylates caveolin-1 (Tyr14). Reason: SRC is found in caveolae and phosphorylates caveolin-1 (Tyr14); a real but context-specific localisation. |
| GO:0005911 cell-cell junction | IDA PMID:22294297 Non-junctional human desmoglein 3 acts as an upstream regula... | ACCEPT | Summary: IDA annotation to cell-cell junction (GO:0005911) from PMID:22294297. SRC is active at cell-cell junctions (adherens junctions) where it phosphorylates catenins. Reason: SRC is active at cell-cell junctions (adherens junctions) where it phosphorylates catenins; supported by the desmoglein-3/E-cadherin study. Supporting Evidence: PMID:22294297 Modulation of Dsg3 levels, either by Dsg3 silencing or over-expression, alters Src activity and its association with E-cadherin. |
| GO:0005925 focal adhesion | IEA GO_REF:0000120 | ACCEPT | Summary: IEA annotation to focal adhesion (GO:0005925) from GO_REF:0000120. Focal adhesions are a principal site of SRC action. Reason: Focal adhesions are a principal site of SRC action; active SRC relocates from endosomes to focal adhesions (PMID:7525268). Supporting Evidence: PMID:7525268 Mutation of this tyrosine dramatically redistributes c-Src from endosomal membranes to focal adhesions. |
| GO:0005925 focal adhesion | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation to focal adhesion (GO:0005925) from GO_REF:0000024. Focal adhesions are a principal site of SRC action. Reason: Focal adhesions are a principal site of SRC action; active SRC relocates from endosomes to focal adhesions (PMID:7525268). Supporting Evidence: PMID:7525268 Mutation of this tyrosine dramatically redistributes c-Src from endosomal membranes to focal adhesions. |
| GO:0007155 cell adhesion | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation to cell adhesion (GO:0007155) from GO_REF:0000033. SRC-family kinases regulate integrin- and cadherin-based adhesion. Reason: SRC-family kinases regulate integrin- and cadherin-based adhesion; the IBA placement at the Src-family node is reasonable. Cell adhesion is a broad but defensible process term for SRC. |
| GO:0007165 signal transduction | TAS PMID:10734107 The beta(2)-adrenergic receptor mediates extracellular signa... | ACCEPT | Summary: TAS annotation to signal transduction (GO:0007165) from PMID:10734107. SRC is a signal transducer downstream of many receptors. Reason: SRC is a signal transducer downstream of many receptors; the broad signal transduction term is correct. |
| GO:0007165 signal transduction | TAS PMID:9020193 Gbetagamma subunits mediate Src-dependent phosphorylation of... | ACCEPT | Summary: TAS annotation to signal transduction (GO:0007165) from PMID:9020193. SRC is a signal transducer downstream of many receptors. Reason: SRC is a signal transducer downstream of many receptors; the broad signal transduction term is correct. |
| GO:0007172 signal complex assembly | TAS PMID:9924018 Beta-arrestin-dependent formation of beta2 adrenergic recept... | MARK AS OVER ANNOTATED | Summary: TAS annotation to signal complex assembly (GO:0007172) from PMID:9924018. SRC is recruited into beta-arrestin/beta2-adrenergic receptor complexes, but it is a component rather than an assembler of the signalling complex. Reason: SRC is recruited into beta-arrestin/beta2-adrenergic receptor complexes, but it is a component rather than an assembler of the signalling complex; signal complex assembly over-states its role. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: IBA annotation to epidermal growth factor receptor signaling pathway (GO:0007173) from GO_REF:0000033. SRC binds and phosphorylates EGFR (e.g. Reason: SRC binds and phosphorylates EGFR (e.g. Tyr845) and is required for EGF-induced signalling; a well-supported pathway role. |
| GO:0007173 epidermal growth factor receptor signaling pathway | TAS Reactome:R-HSA-177929 | ACCEPT | Summary: TAS annotation to epidermal growth factor receptor signaling pathway (GO:0007173) from Reactome:R-HSA-177929. SRC binds and phosphorylates EGFR (e.g. Reason: SRC binds and phosphorylates EGFR (e.g. Tyr845) and is required for EGF-induced signalling; a well-supported pathway role. |
| GO:0007179 transforming growth factor beta receptor signaling pathway | IMP PMID:24036928 Integrin-Ξ²5 and zyxin mediate formation of ventral stress fi... | MARK AS OVER ANNOTATED | Summary: IMP annotation to transforming growth factor beta receptor signaling pathway (GO:0007179) from PMID:24036928. In PMID:24036928 SRC kinase activity is needed for integrin-beta5-dependent ventral stress fibre formation in response to TGF-beta. Reason: In PMID:24036928 SRC kinase activity is needed for integrin-beta5-dependent ventral stress fibre formation in response to TGF-beta; SRC acts in the integrin arm, not in TGF-beta receptor signalling itself. Supporting Evidence: PMID:24036928 In addition, the integrity of actin fibers and Src kinase activity contribute to integrin-Ξ²5-mediated signaling and VSF formation. |
| GO:0007229 integrin-mediated signaling pathway | IMP PMID:24036928 Integrin-Ξ²5 and zyxin mediate formation of ventral stress fi... | ACCEPT | Summary: IMP annotation to integrin-mediated signaling pathway (GO:0007229) from PMID:24036928. SRC is a central transducer of integrin signalling (with FAK). Reason: SRC is a central transducer of integrin signalling (with FAK); PMID:24036928 shows SRC activity is needed for integrin-beta5 signalling. Core process. Supporting Evidence: PMID:24036928 In addition, the integrity of actin fibers and Src kinase activity contribute to integrin-Ξ²5-mediated signaling and VSF formation. |
| GO:0007595 lactation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to lactation (GO:0007595) from GO_REF:0000107. Transferred from mouse Src, where loss affects mammary function. Reason: Transferred from mouse Src, where loss affects mammary function; an organism-level phenotype and not a core SRC function. |
| GO:0010632 regulation of epithelial cell migration | IMP PMID:21724833 Identification of PTPN23 as a novel regulator of cell invasi... | KEEP AS NON CORE | Summary: IMP annotation to regulation of epithelial cell migration (GO:0010632) from PMID:21724833. SRC inhibition reversed the PTPN23-depletion phenotypes including increased motility (PMID:21724833). Reason: SRC inhibition reversed the PTPN23-depletion phenotypes including increased motility (PMID:21724833). SRC regulates epithelial migration through adhesion signalling; non-core context. Supporting Evidence: PMID:21724833 Inhibition of SRC with the small molecular inhibitor SU6656 blocked the effects of PTPN23 depletion. |
| GO:0010634 positive regulation of epithelial cell migration | IMP PMID:18054784 Autotaxin and lysophosphatidic acid stimulate intestinal cel... | KEEP AS NON CORE | Summary: IMP annotation to positive regulation of epithelial cell migration (GO:0010634) from PMID:18054784. LPA-induced epithelial cell migration required c-src kinase and its phosphorylation of villin (PMID:18054784). Reason: LPA-induced epithelial cell migration required c-src kinase and its phosphorylation of villin (PMID:18054784). Valid, context-specific. Supporting Evidence: PMID:18054784 The LPA-induced increase in cell migration required activation of c-src kinase and downstream tyrosine phosphorylation of villin by c-src kinase. |
| GO:0016004 phospholipase activator activity | IDA PMID:11606584 Tyrosine residues in phospholipase Cgamma 2 essential for th... | MARK AS OVER ANNOTATED | Summary: IDA annotation to phospholipase activator activity (GO:0016004) from PMID:11606584. SRC phosphorylates PLC-gamma isoforms. Reason: SRC phosphorylates PLC-gamma isoforms; activation by phosphorylation is captured by kinase activity, whereas phospholipase activator activity implies a non-catalytic activator role. The cached abstract attributes PLCgamma2 phosphorylation mainly to Btk/Syk, so this row over-states SRC function. |
| GO:0016020 membrane | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation to membrane (GO:0016020) from GO_REF:0000107. SRC is a myristoylated membrane-associated protein. Reason: SRC is a myristoylated membrane-associated protein; the general membrane term is correct. |
| GO:0016236 macroautophagy | TAS Reactome:R-HSA-8934903 | KEEP AS NON CORE | Summary: TAS annotation to macroautophagy (GO:0016236) from Reactome:R-HSA-8934903. Reactome includes SRC in mitophagy/autophagy reactions (SRC phosphorylation of a mitophagy receptor), a regulatory, context-specific role rather than core autophagy machinery. Reason: Reactome includes SRC in mitophagy/autophagy reactions (SRC phosphorylation of a mitophagy receptor), a regulatory, context-specific role rather than core autophagy machinery. |
| GO:0016301 kinase activity | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation to kinase activity (GO:0016301) from GO_REF:0000107. Broad electronic kinase activity annotation. Reason: Broad electronic kinase activity annotation; correct though less specific than protein tyrosine kinase activity. |
| GO:0018108 peptidyl-tyrosine phosphorylation | IDA PMID:22732588 Interchangeability of Themis1 and Themis2 in thymocyte devel... | ACCEPT | Summary: IDA annotation to peptidyl-tyrosine phosphorylation (GO:0018108) from PMID:22732588. Peptidyl-tyrosine phosphorylation is the process directly carried out by SRC catalytic activity. Reason: Peptidyl-tyrosine phosphorylation is the process directly carried out by SRC catalytic activity. |
| GO:0019899 enzyme binding | IPI PMID:21724833 Identification of PTPN23 as a novel regulator of cell invasi... | KEEP AS NON CORE | Summary: IPI annotation to enzyme binding (GO:0019899) from PMID:21724833. SRC is a direct substrate of the phosphatase PTPN23 (substrate-trapping interaction, PMID:21724833). Reason: SRC is a direct substrate of the phosphatase PTPN23 (substrate-trapping interaction, PMID:21724833). Enzyme binding is generic; the interaction is a regulatory enzyme-substrate relationship, kept as non-core. Supporting Evidence: PMID:21724833 Inhibition of SRC with the small molecular inhibitor SU6656 blocked the effects of PTPN23 depletion. |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to protein domain specific binding (GO:0019904) from GO_REF:0000107. SRC SH2/SH3 domains engage specific partner motifs. Reason: SRC SH2/SH3 domains engage specific partner motifs; protein domain specific binding is vague but not wrong. More specific terms (phosphotyrosine residue binding, proline-rich region binding, PDZ domain binding) are proposed elsewhere. |
| GO:0020037 heme binding | IDA PMID:21036157 Heme controls the regulation of protein tyrosine kinases Jak... | KEEP AS NON CORE | Summary: IDA annotation to heme binding (GO:0020037) from PMID:21036157. Purified SRC binds heme, and heme modulates SRC tail phosphorylation (PMID:21036157). Reason: Purified SRC binds heme, and heme modulates SRC tail phosphorylation (PMID:21036157); a regulatory ligand interaction, not a core function. Supporting Evidence: PMID:21036157 Further experiments showed that Jak2 and Src bind to heme and that the presence of heme alters the sensitivity of Jak2 and Src to trypsin digestion. |
| GO:0022407 regulation of cell-cell adhesion | IMP PMID:21724833 Identification of PTPN23 as a novel regulator of cell invasi... | KEEP AS NON CORE | Summary: IMP annotation to regulation of cell-cell adhesion (GO:0022407) from PMID:21724833. SRC activity underlies the cell-cell adhesion changes after PTPN23 loss (PMID:21724833). Reason: SRC activity underlies the cell-cell adhesion changes after PTPN23 loss (PMID:21724833); context-specific regulation. Supporting Evidence: PMID:21724833 Inhibition of SRC with the small molecular inhibitor SU6656 blocked the effects of PTPN23 depletion. |
| GO:0030054 cell junction | IDA GO_REF:0000052 | ACCEPT | Summary: IDA annotation to cell junction (GO:0030054) from GO_REF:0000052. SRC localises to cell junctions (adherens junctions, focal adhesions). Reason: SRC localises to cell junctions (adherens junctions, focal adhesions); consistent with its known sites of action. |
| GO:0030154 cell differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation to cell differentiation (GO:0030154) from GO_REF:0000033. SRC-family kinases act in many differentiation programmes. Reason: SRC-family kinases act in many differentiation programmes; the IBA is broad and pleiotropic, not a core SRC function. |
| GO:0030168 platelet activation | TAS Reactome:R-HSA-76002 | KEEP AS NON CORE | Summary: TAS annotation to platelet activation (GO:0030168) from Reactome:R-HSA-76002. SRC participates in integrin alphaIIb-beta3 and GPVI signalling in platelets (Reactome). Reason: SRC participates in integrin alphaIIb-beta3 and GPVI signalling in platelets (Reactome); valid but cell-type specific. |
| GO:0030296 protein tyrosine kinase activator activity | NAS PMID:20018849 JNK pathway-associated phosphatase dephosphorylates focal ad... | MARK AS OVER ANNOTATED | Summary: NAS annotation to protein tyrosine kinase activator activity (GO:0030296) from PMID:20018849. SRC phosphorylates FAK (Tyr576/577) and thereby increases FAK activity, but this is captured by protein tyrosine kinase activity. Reason: SRC phosphorylates FAK (Tyr576/577) and thereby increases FAK activity, but this is captured by protein tyrosine kinase activity; protein tyrosine kinase activator activity (a non-catalytic activator role) over-states it. NAS-only support. |
| GO:0030316 osteoclast differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to osteoclast differentiation (GO:0030316) from GO_REF:0000024. Transferred from mouse Src. Reason: Transferred from mouse Src. SRC is essential for osteoclast bone-resorbing function; its role in differentiation itself is less clear, so this is kept as non-core rather than as a core process. |
| GO:0030546 signaling receptor activator activity | ISS GO_REF:0000024 | REMOVE | Summary: ISS annotation to signaling receptor activator activity (GO:0030546) from GO_REF:0000024. ISS from rat Src. Reason: ISS from rat Src. SRC potentiates receptors such as NMDA receptors by phosphorylating them; signaling receptor activator activity denotes a ligand-like activator, which mistypes a kinase-mediated effect. The appropriate MF is protein tyrosine kinase activity, already annotated. |
| GO:0031295 T cell costimulation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation to T cell costimulation (GO:0031295) from GO_REF:0000117. Reactome/ARBA place SRC in CD28 costimulation. Reason: Reactome/ARBA place SRC in CD28 costimulation; in T cells LCK and FYN are the main SRC-family kinases, so this is a minor, context-specific role. |
| GO:0031295 T cell costimulation | TAS Reactome:R-HSA-388841 | KEEP AS NON CORE | Summary: TAS annotation to T cell costimulation (GO:0031295) from Reactome:R-HSA-388841. Reactome/ARBA place SRC in CD28 costimulation. Reason: Reactome/ARBA place SRC in CD28 costimulation; in T cells LCK and FYN are the main SRC-family kinases, so this is a minor, context-specific role. |
| GO:0031295 T cell costimulation | TAS Reactome:R-HSA-389356 | KEEP AS NON CORE | Summary: TAS annotation to T cell costimulation (GO:0031295) from Reactome:R-HSA-389356. Reactome/ARBA place SRC in CD28 costimulation. Reason: Reactome/ARBA place SRC in CD28 costimulation; in T cells LCK and FYN are the main SRC-family kinases, so this is a minor, context-specific role. |
| GO:0031333 negative regulation of protein-containing complex assembly | IMP PMID:19767770 A novel pro-apoptotic function of RACK1: suppression of Src ... | KEEP AS NON CORE | Summary: IMP annotation to negative regulation of protein-containing complex assembly (GO:0031333) from PMID:19767770. RACK1 promotes Bax oligomerisation partly by inhibiting SRC (PMID:19767770). Reason: RACK1 promotes Bax oligomerisation partly by inhibiting SRC (PMID:19767770); SRC thus negatively regulates this complex assembly indirectly. Context-specific. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:0031648 protein destabilization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to protein destabilization (GO:0031648) from GO_REF:0000107. SRC phosphorylation can target substrates (e.g. Reason: SRC phosphorylation can target substrates (e.g. caveolin-1, E-cadherin) for degradation; electronic transfer, non-core. |
| GO:0032205 negative regulation of telomere maintenance | IMP PMID:21531765 High-throughput RNAi screening reveals novel regulators of t... | MARK AS OVER ANNOTATED | Summary: IMP annotation to negative regulation of telomere maintenance (GO:0032205) from PMID:21531765. Kinome RNAi screen read-out (telomerase activity). Reason: Kinome RNAi screen read-out (telomerase activity); SRC acts upstream through signalling, not within telomere maintenance. Over-annotation from an indirect screen phenotype. |
| GO:0032587 ruffle membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to ruffle membrane (GO:0032587) from GO_REF:0000107. Electronic transfer from mouse Src. Reason: Electronic transfer from mouse Src; SRC localises to membrane ruffles during growth-factor-induced actin remodelling. A minor, context-dependent location. |
| GO:0033625 positive regulation of integrin activation | TAS PMID:19267251 Cooperation between integrin alphavbeta3 and VEGFR2 in angio... | KEEP AS NON CORE | Summary: TAS annotation to positive regulation of integrin activation (GO:0033625) from PMID:19267251. SRC participates in integrin inside-out/outside-in activation loops (review evidence, PMID:19267251). Reason: SRC participates in integrin inside-out/outside-in activation loops (review evidence, PMID:19267251); non-core. |
| GO:0034139 regulation of toll-like receptor 3 signaling pathway | IDA PMID:37158982 The Src-ZNRF1 axis controls TLR3 trafficking and interferon ... | KEEP AS NON CORE | Summary: IDA annotation to regulation of toll-like receptor 3 signaling pathway (GO:0034139) from PMID:37158982. SRC activated by TLR3 phosphorylates ZNRF1, driving TLR3 lysosomal trafficking and signal termination (PMID:37158982. Reason: SRC activated by TLR3 phosphorylates ZNRF1, driving TLR3 lysosomal trafficking and signal termination (PMID:37158982; also modelled in a GO-CAM). A specific downstream role, non-core. Supporting Evidence: PMID:37158982 Mechanistically, c-Src kinase activated by TLR3 engagement phosphorylates ZNRF1 at tyrosine 103, which mediates K63-linked ubiquitination of TLR3 at lysine 813 and promotes TLR3 lysosomal trafficking and degradation. |
| GO:0034614 cellular response to reactive oxygen species | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation to cellular response to reactive oxygen species (GO:0034614) from GO_REF:0000117. SRC phosphorylates plakophilin 3 in response to reactive oxygen species (PMID:25501895). Reason: SRC phosphorylates plakophilin 3 in response to reactive oxygen species (PMID:25501895); a context-specific response. |
| GO:0034614 cellular response to reactive oxygen species | IMP PMID:25501895 c-Src mediated tyrosine phosphorylation of plakophilin 3 as ... | KEEP AS NON CORE | Summary: IMP annotation to cellular response to reactive oxygen species (GO:0034614) from PMID:25501895. SRC phosphorylates plakophilin 3 in response to reactive oxygen species (PMID:25501895). Reason: SRC phosphorylates plakophilin 3 in response to reactive oxygen species (PMID:25501895); a context-specific response. |
| GO:0035022 positive regulation of Rac protein signal transduction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to positive regulation of Rac protein signal transduction (GO:0035022) from GO_REF:0000107. SRC mediates laminin-induced Rac1 activation (GO-CAM model. Reason: SRC mediates laminin-induced Rac1 activation (GO-CAM model; UniProt). Context-specific signalling role. |
| GO:0035022 positive regulation of Rac protein signal transduction | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to positive regulation of Rac protein signal transduction (GO:0035022) from GO_REF:0000024. SRC mediates laminin-induced Rac1 activation (GO-CAM model. Reason: SRC mediates laminin-induced Rac1 activation (GO-CAM model; UniProt). Context-specific signalling role. |
| GO:0035255 ionotropic glutamate receptor binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to ionotropic glutamate receptor binding (GO:0035255) from GO_REF:0000024. ISS from rat Src, which associates with NMDA receptor complexes in neurons. Reason: ISS from rat Src, which associates with NMDA receptor complexes in neurons; a valid neuronal partner-class binding term, non-core. |
| GO:0035306 positive regulation of dephosphorylation | IDA PMID:23159740 VE-cadherin signaling induces EB3 phosphorylation to suppres... | MARK AS OVER ANNOTATED | Summary: IDA annotation to positive regulation of dephosphorylation (GO:0035306) from PMID:23159740. In PMID:23159740 loss of VE-cadherin adhesion activates SRC and PLCgamma2, releasing calcium that activates calcineurin. Reason: In PMID:23159740 loss of VE-cadherin adhesion activates SRC and PLCgamma2, releasing calcium that activates calcineurin; SRC acts several steps upstream of the dephosphorylation. Over-annotation of an indirect effect. |
| GO:0035331 negative regulation of hippo signaling | IMP PMID:33162394 CORO7 functions as a scaffold protein for the core kinase co... | KEEP AS NON CORE | Summary: IMP annotation to negative regulation of hippo signaling (GO:0035331) from PMID:33162394. PMID:33162394 identifies SRC as a candidate regulator of the CORO7 Hippo scaffold. Reason: PMID:33162394 identifies SRC as a candidate regulator of the CORO7 Hippo scaffold. SRC-family kinases inhibit Hippo signalling in several contexts; kept as non-core regulatory role. |
| GO:0035556 intracellular signal transduction | IDA PMID:15248232 Expression and function of RANK in human monocyte chemotaxis... | ACCEPT | Summary: IDA annotation to intracellular signal transduction (GO:0035556) from PMID:15248232. SRC is an intracellular transducer of receptor signals. Reason: SRC is an intracellular transducer of receptor signals; this broad process is correct. |
| GO:0035556 intracellular signal transduction | IDA PMID:26598555 VE-cadherin facilitates BMP-induced endothelial cell permeab... | ACCEPT | Summary: IDA annotation to intracellular signal transduction (GO:0035556) from PMID:26598555. SRC is an intracellular transducer of receptor signals. Reason: SRC is an intracellular transducer of receptor signals; this broad process is correct. |
| GO:0035556 intracellular signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation to intracellular signal transduction (GO:0035556) from GO_REF:0000107. SRC is an intracellular transducer of receptor signals. Reason: SRC is an intracellular transducer of receptor signals; this broad process is correct. |
| GO:0035556 intracellular signal transduction | IMP PMID:11606584 Tyrosine residues in phospholipase Cgamma 2 essential for th... | ACCEPT | Summary: IMP annotation to intracellular signal transduction (GO:0035556) from PMID:11606584. B-cell PLCgamma2 signalling study. Reason: B-cell PLCgamma2 signalling study; SRC acts as an intracellular transducer of receptor signals, so this broad process is correct, as for the other rows for this term. |
| GO:0035556 intracellular signal transduction | IMP PMID:26706435 PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation... | ACCEPT | Summary: IMP annotation to intracellular signal transduction (GO:0035556) from PMID:26706435. SRC is an intracellular transducer of receptor signals. Reason: SRC is an intracellular transducer of receptor signals; this broad process is correct. |
| GO:0035556 intracellular signal transduction | TAS PMID:9020193 Gbetagamma subunits mediate Src-dependent phosphorylation of... | ACCEPT | Summary: TAS annotation to intracellular signal transduction (GO:0035556) from PMID:9020193. SRC is an intracellular transducer of receptor signals. Reason: SRC is an intracellular transducer of receptor signals; this broad process is correct. |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation to Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) from GO_REF:0000117. SRC-family kinases phosphorylate Fc-gamma receptor ITAMs during phagocytosis (Reactome). Reason: SRC-family kinases phosphorylate Fc-gamma receptor ITAMs during phagocytosis (Reactome); a context-specific immune role. |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | TAS Reactome:R-HSA-2029480 | KEEP AS NON CORE | Summary: TAS annotation to Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) from Reactome:R-HSA-2029480. SRC-family kinases phosphorylate Fc-gamma receptor ITAMs during phagocytosis (Reactome). Reason: SRC-family kinases phosphorylate Fc-gamma receptor ITAMs during phagocytosis (Reactome); a context-specific immune role. |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | TAS Reactome:R-HSA-9664422 | KEEP AS NON CORE | Summary: TAS annotation to Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) from Reactome:R-HSA-9664422. SRC-family kinases phosphorylate Fc-gamma receptor ITAMs during phagocytosis (Reactome). Reason: SRC-family kinases phosphorylate Fc-gamma receptor ITAMs during phagocytosis (Reactome); a context-specific immune role. |
| GO:0038128 ERBB2 signaling pathway | TAS Reactome:R-HSA-1227986 | KEEP AS NON CORE | Summary: TAS annotation to ERBB2 signaling pathway (GO:0038128) from Reactome:R-HSA-1227986. SRC associates with and amplifies ERBB2 signalling (Reactome). Reason: SRC associates with and amplifies ERBB2 signalling (Reactome); context-specific. |
| GO:0038166 angiotensin-activated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to angiotensin-activated signaling pathway (GO:0038166) from GO_REF:0000107. SRC is activated downstream of the AT1 angiotensin receptor (transferred from mouse Src). Reason: SRC is activated downstream of the AT1 angiotensin receptor (transferred from mouse Src); context-specific. |
| GO:0038166 angiotensin-activated signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to angiotensin-activated signaling pathway (GO:0038166) from GO_REF:0000024. SRC is activated downstream of the AT1 angiotensin receptor (transferred from mouse Src). Reason: SRC is activated downstream of the AT1 angiotensin receptor (transferred from mouse Src); context-specific. |
| GO:0042169 SH2 domain binding | IPI PMID:8070403 A novel signaling molecule, p130, forms stable complexes in ... | UNDECIDED | Summary: IPI annotation to SH2 domain binding (GO:0042169) from PMID:8070403. SH2 domain binding means SRC binds the SH2 domain of a partner. Reason: SH2 domain binding means SRC binds the SH2 domain of a partner. The partner given (p130Cas) has no SH2 domain; the cached abstract reports stable p130Cas/v-Crk/v-Src complexes but not SRC binding an SH2 domain. Without the full text the specific claim cannot be verified. |
| GO:0042311 vasodilation | IMP PMID:26706435 PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation... | MARK AS OVER ANNOTATED | Summary: IMP annotation to vasodilation (GO:0042311) from PMID:26706435. siRNA/ex vivo endothelial signalling (PECAM1-Gab1-eNOS) does not establish SRC as acting within the organism-level process of vasodilation. Reason: siRNA/ex vivo endothelial signalling (PECAM1-Gab1-eNOS) does not establish SRC as acting within the organism-level process of vasodilation; over-annotation. |
| GO:0043066 negative regulation of apoptotic process | IMP PMID:19767770 A novel pro-apoptotic function of RACK1: suppression of Src ... | KEEP AS NON CORE | Summary: IMP annotation to negative regulation of apoptotic process (GO:0043066) from PMID:19767770. RACK1 induces apoptosis partly by inhibiting SRC, implying SRC supports survival (PMID:19767770). Reason: RACK1 induces apoptosis partly by inhibiting SRC, implying SRC supports survival (PMID:19767770); a downstream, context-specific role. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:0043114 regulation of vascular permeability | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation to regulation of vascular permeability (GO:0043114) from GO_REF:0000117. SRC phosphorylation of VE-cadherin and other junctional proteins increases vascular permeability (review and ARBA evidence). Reason: SRC phosphorylation of VE-cadherin and other junctional proteins increases vascular permeability (review and ARBA evidence); non-core tissue-level role. |
| GO:0043114 regulation of vascular permeability | TAS PMID:19267251 Cooperation between integrin alphavbeta3 and VEGFR2 in angio... | KEEP AS NON CORE | Summary: TAS annotation to regulation of vascular permeability (GO:0043114) from PMID:19267251. SRC phosphorylation of VE-cadherin and other junctional proteins increases vascular permeability (review and ARBA evidence). Reason: SRC phosphorylation of VE-cadherin and other junctional proteins increases vascular permeability (review and ARBA evidence); non-core tissue-level role. |
| GO:0043149 stress fiber assembly | IMP PMID:24036928 Integrin-Ξ²5 and zyxin mediate formation of ventral stress fi... | KEEP AS NON CORE | Summary: IMP annotation to stress fiber assembly (GO:0043149) from PMID:24036928. SRC kinase activity contributes to TGF-beta/integrin-beta5-induced ventral stress fibre formation (PMID:24036928). Reason: SRC kinase activity contributes to TGF-beta/integrin-beta5-induced ventral stress fibre formation (PMID:24036928); context-specific. Supporting Evidence: PMID:24036928 In addition, the integrity of actin fibers and Src kinase activity contribute to integrin-Ξ²5-mediated signaling and VSF formation. |
| GO:0043274 phospholipase binding | IPI PMID:11606584 Tyrosine residues in phospholipase Cgamma 2 essential for th... | KEEP AS NON CORE | Summary: IPI annotation to phospholipase binding (GO:0043274) from PMID:11606584. SRC associates with phospholipase C-gamma as kinase and substrate. Reason: SRC associates with phospholipase C-gamma as kinase and substrate; partner-class binding term, non-core. |
| GO:0044325 transmembrane transporter binding | IPI PMID:12538589 Regulation of a transient receptor potential (TRP) channel b... | KEEP AS NON CORE | Summary: IPI annotation to transmembrane transporter binding (GO:0044325) from PMID:12538589. TRPV4 associates with SRC-family kinases in an SH2-dependent manner (PMID:12538589). Reason: TRPV4 associates with SRC-family kinases in an SH2-dependent manner (PMID:12538589); partner-class binding, non-core. Supporting Evidence: PMID:12538589 TRPV4 associated with Src family kinases by co-immunoprecipitation studies and confocal immunofluorescence microscopy, and this interaction required an intact Src family kinase SH2 domain. |
| GO:0044325 transmembrane transporter binding | IPI PMID:8953041 Association of Src tyrosine kinase with a human potassium ch... | KEEP AS NON CORE | Summary: IPI annotation to transmembrane transporter binding (GO:0044325) from PMID:8953041. Direct association of SRC with the Kv1.5 potassium channel via its SH3 domain and the channel proline-rich motif (PMID:8953041). Reason: Direct association of SRC with the Kv1.5 potassium channel via its SH3 domain and the channel proline-rich motif (PMID:8953041); partner-class binding, non-core. Supporting Evidence: PMID:8953041 This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src. |
| GO:0045121 membrane raft | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation to membrane raft (GO:0045121) from GO_REF:0000024. SRC partitions into membrane rafts (lipid-modified, myristoylated). Reason: SRC partitions into membrane rafts (lipid-modified, myristoylated); rafts are a well-documented site of SRC-family signalling. |
| GO:0045124 regulation of bone resorption | TAS PMID:19267251 Cooperation between integrin alphavbeta3 and VEGFR2 in angio... | KEEP AS NON CORE | Summary: TAS annotation to regulation of bone resorption (GO:0045124) from PMID:19267251. SRC is required for osteoclast bone resorption (review evidence). Reason: SRC is required for osteoclast bone resorption (review evidence); tissue-level, non-core. |
| GO:0045296 cadherin binding | HDA PMID:25468996 E-cadherin interactome complexity and robustness resolved by... | KEEP AS NON CORE | Summary: HDA annotation to cadherin binding (GO:0045296) from PMID:25468996. SRC was identified in a proteomic E-cadherin interactome (HDA). Reason: SRC was identified in a proteomic E-cadherin interactome (HDA); SRC is active at cadherin junctions, but the high-throughput association is non-core. |
| GO:0045453 bone resorption | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to bone resorption (GO:0045453) from GO_REF:0000107. SRC is essential for osteoclast-mediated bone resorption in mouse (transferred annotation). Reason: SRC is essential for osteoclast-mediated bone resorption in mouse (transferred annotation); a tissue-level role, non-core. |
| GO:0045453 bone resorption | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to bone resorption (GO:0045453) from GO_REF:0000024. SRC is essential for osteoclast-mediated bone resorption in mouse (transferred annotation). Reason: SRC is essential for osteoclast-mediated bone resorption in mouse (transferred annotation); a tissue-level role, non-core. |
| GO:0045747 positive regulation of Notch signaling pathway | IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege... | KEEP AS NON CORE | Summary: IDA annotation to positive regulation of Notch signaling pathway (GO:0045747) from PMID:25731159. gp130 activates SRC, which drives YAP and Notch activation during epithelial regeneration (PMID:25731159). Reason: gp130 activates SRC, which drives YAP and Notch activation during epithelial regeneration (PMID:25731159); context-specific. Supporting Evidence: PMID:25731159 Receptor binding by IL-6 and related cytokines engages gp130, which in addition to its well established effectors, the SHP-2-ERK, PI3K-Akt-mTORC1 and JAK-STAT3 modules, interacts with and activates Src and Yes. |
| GO:0045747 positive regulation of Notch signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to positive regulation of Notch signaling pathway (GO:0045747) from GO_REF:0000107. gp130 activates SRC, which drives YAP and Notch activation during epithelial regeneration (PMID:25731159). Reason: gp130 activates SRC, which drives YAP and Notch activation during epithelial regeneration (PMID:25731159); context-specific. Supporting Evidence: PMID:25731159 Receptor binding by IL-6 and related cytokines engages gp130, which in addition to its well established effectors, the SHP-2-ERK, PI3K-Akt-mTORC1 and JAK-STAT3 modules, interacts with and activates Src and Yes. |
| GO:0045821 positive regulation of glycolysis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to positive regulation of glycolysis (GO:0045821) from GO_REF:0000107. SRC phosphorylates and activates hexokinase (PMID:28054552). Reason: SRC phosphorylates and activates hexokinase (PMID:28054552); electronic transfer of a metabolic regulatory role, non-core. |
| GO:0045937 positive regulation of phosphate metabolic process | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: IEA annotation to positive regulation of phosphate metabolic process (GO:0045937) from GO_REF:0000117. ARBA prediction. Reason: ARBA prediction; positive regulation of phosphate metabolic process is too vague to describe SRC function and adds nothing beyond its kinase activity. |
| GO:0046718 symbiont entry into host cell | TAS Reactome:R-HSA-8876493 | KEEP AS NON CORE | Summary: TAS annotation to symbiont entry into host cell (GO:0046718) from Reactome:R-HSA-8876493. Host SRC participates in pathogen entry reactions in Reactome (host factor). Reason: Host SRC participates in pathogen entry reactions in Reactome (host factor). Non-core. |
| GO:0046875 ephrin receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to ephrin receptor binding (GO:0046875) from GO_REF:0000107. SRC binds activated EphB1 through phosphotyrosines Y600/Y778 (PMID:12925710). Reason: SRC binds activated EphB1 through phosphotyrosines Y600/Y778 (PMID:12925710); a partner-class binding term, non-core. Supporting Evidence: PMID:12925710 Site-directed mutagenesis experiments demonstrate that tyrosines 600 and 778 of EphB1 are required for its interaction with c-Src and p52Shc. |
| GO:0046875 ephrin receptor binding | IPI PMID:12925710 EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and pro... | KEEP AS NON CORE | Summary: IPI annotation to ephrin receptor binding (GO:0046875) from PMID:12925710. SRC binds activated EphB1 through phosphotyrosines Y600/Y778 (PMID:12925710). Reason: SRC binds activated EphB1 through phosphotyrosines Y600/Y778 (PMID:12925710); a partner-class binding term, non-core. Supporting Evidence: PMID:12925710 Site-directed mutagenesis experiments demonstrate that tyrosines 600 and 778 of EphB1 are required for its interaction with c-Src and p52Shc. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | TAS Reactome:R-HSA-194138 | KEEP AS NON CORE | Summary: TAS annotation to vascular endothelial growth factor receptor signaling pathway (GO:0048010) from Reactome:R-HSA-194138. SRC is activated downstream of VEGFR2 and mediates endothelial permeability signalling (Reactome). Reason: SRC is activated downstream of VEGFR2 and mediates endothelial permeability signalling (Reactome); context-specific. |
| GO:0048013 ephrin receptor signaling pathway | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation to ephrin receptor signaling pathway (GO:0048013) from GO_REF:0000117. SRC is recruited to Eph receptors and participates in ephrin signalling (Reactome, ARBA). Reason: SRC is recruited to Eph receptors and participates in ephrin signalling (Reactome, ARBA); context-specific. Supporting Evidence: PMID:12925710 Site-directed mutagenesis experiments demonstrate that tyrosines 600 and 778 of EphB1 are required for its interaction with c-Src and p52Shc. |
| GO:0048013 ephrin receptor signaling pathway | TAS Reactome:R-HSA-2682334 | KEEP AS NON CORE | Summary: TAS annotation to ephrin receptor signaling pathway (GO:0048013) from Reactome:R-HSA-2682334. SRC is recruited to Eph receptors and participates in ephrin signalling (Reactome, ARBA). Reason: SRC is recruited to Eph receptors and participates in ephrin signalling (Reactome, ARBA); context-specific. Supporting Evidence: PMID:12925710 Site-directed mutagenesis experiments demonstrate that tyrosines 600 and 778 of EphB1 are required for its interaction with c-Src and p52Shc. |
| GO:0048041 focal adhesion assembly | IMP PMID:21411625 A direct interaction between the large GTPase dynamin-2 and ... | MODIFY | Summary: IMP annotation to focal adhesion assembly (GO:0048041) from PMID:21411625. PMID:21411625 shows that the SRC-FAK-dynamin-2 complex is required for focal adhesion turnover and disassembly, not assembly. Reason: PMID:21411625 shows that the SRC-FAK-dynamin-2 complex is required for focal adhesion turnover and disassembly, not assembly. Replace with focal adhesion disassembly (GO:0120181). Proposed replacements: focal adhesion disassembly Supporting Evidence: PMID:21411625 This Src-FAK-Dyn2 trimeric complex is essential for FA turnover, as mutants disrupting the formation of this complex inhibit FA disassembly. |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:19307596 Reversion-induced LIM interaction with Src reveals a novel S... | KEEP AS NON CORE | Summary: IDA annotation to perinuclear region of cytoplasm (GO:0048471) from PMID:19307596. SRC colocalises with partners in the perinuclear region (e.g. Reason: SRC colocalises with partners in the perinuclear region (e.g. RIL, MVP) as part of its trafficking; minor localisation. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: IEA annotation to perinuclear region of cytoplasm (GO:0048471) from GO_REF:0000120. SRC colocalises with partners in the perinuclear region (e.g. Reason: SRC colocalises with partners in the perinuclear region (e.g. RIL, MVP) as part of its trafficking; minor localisation. |
| GO:0050847 progesterone receptor signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation to progesterone receptor signaling pathway (GO:0050847) from GO_REF:0000033. SRC is activated by ligand-bound progesterone receptor in non-genomic signalling. Reason: SRC is activated by ligand-bound progesterone receptor in non-genomic signalling; the IBA/ISS is plausible but represents a context-specific pathway. |
| GO:0050847 progesterone receptor signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to progesterone receptor signaling pathway (GO:0050847) from GO_REF:0000024. SRC is activated by ligand-bound progesterone receptor in non-genomic signalling. Reason: SRC is activated by ligand-bound progesterone receptor in non-genomic signalling; the IBA/ISS is plausible but represents a context-specific pathway. |
| GO:0050900 leukocyte migration | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation to leukocyte migration (GO:0050900) from GO_REF:0000117. SRC-family kinases act in leukocyte adhesion/migration signalling (Reactome, ARBA). Reason: SRC-family kinases act in leukocyte adhesion/migration signalling (Reactome, ARBA); cell-type specific. |
| GO:0050900 leukocyte migration | TAS Reactome:R-HSA-202733 | KEEP AS NON CORE | Summary: TAS annotation to leukocyte migration (GO:0050900) from Reactome:R-HSA-202733. SRC-family kinases act in leukocyte adhesion/migration signalling (Reactome, ARBA). Reason: SRC-family kinases act in leukocyte adhesion/migration signalling (Reactome, ARBA); cell-type specific. |
| GO:0051057 positive regulation of small GTPase mediated signal transduction | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: IEA annotation to positive regulation of small GTPase mediated signal transduction (GO:0051057) from GO_REF:0000117. PACAP38-induced Rin GTPase activation is SRC-dependent (PMID:18541665). Reason: PACAP38-induced Rin GTPase activation is SRC-dependent (PMID:18541665); a context-specific regulatory role. |
| GO:0051057 positive regulation of small GTPase mediated signal transduction | IMP PMID:18541665 Pituitary adenylate cyclase-activating polypeptide 38-mediat... | KEEP AS NON CORE | Summary: IMP annotation to positive regulation of small GTPase mediated signal transduction (GO:0051057) from PMID:18541665. PACAP38-induced Rin GTPase activation is SRC-dependent (PMID:18541665). Reason: PACAP38-induced Rin GTPase activation is SRC-dependent (PMID:18541665); a context-specific regulatory role. |
| GO:0051117 ATPase binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to ATPase binding (GO:0051117) from GO_REF:0000024. ISS from bovine Src. Reason: ISS from bovine Src; SRC associates with the Na+/K+-ATPase in a signalling complex. Partner-class binding, non-core. |
| GO:0051219 phosphoprotein binding | IPI PMID:16441665 Crosstalk between Src and major vault protein in epidermal g... | MODIFY | Summary: IPI annotation to phosphoprotein binding (GO:0051219) from PMID:16441665. The interaction with major vault protein requires MVP tyrosine phosphorylation and is mediated by the SRC SH2 domain. Reason: The interaction with major vault protein requires MVP tyrosine phosphorylation and is mediated by the SRC SH2 domain; phosphotyrosine residue binding (GO:0001784) states the actual binding activity. Proposed replacements: phosphotyrosine residue binding Supporting Evidence: PMID:16441665 We found MVP as a Src-SH2 binding protein in human stomach tissue. PMID:16441665 We found that the interaction between Src and MVP is critically dependent on Src activity and protein (MVP) tyrosyl phosphorylation |
| GO:0051895 negative regulation of focal adhesion assembly | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to negative regulation of focal adhesion assembly (GO:0051895) from GO_REF:0000024. SRC promotes focal adhesion turnover. Reason: SRC promotes focal adhesion turnover; ISS from rat. Kept as non-core regulatory role. Supporting Evidence: PMID:21411625 This Src-FAK-Dyn2 trimeric complex is essential for FA turnover, as mutants disrupting the formation of this complex inhibit FA disassembly. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:19767770 A novel pro-apoptotic function of RACK1: suppression of Src ... | KEEP AS NON CORE | Summary: IMP annotation to positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897) from PMID:19767770. SRC activates PI3K/AKT signalling (RACK1 study, Reactome). Reason: SRC activates PI3K/AKT signalling (RACK1 study, Reactome); downstream context-specific role. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | TAS Reactome:R-HSA-9603381 | KEEP AS NON CORE | Summary: TAS annotation to positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897) from Reactome:R-HSA-9603381. SRC activates PI3K/AKT signalling (RACK1 study, Reactome). Reason: SRC activates PI3K/AKT signalling (RACK1 study, Reactome); downstream context-specific role. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:0051902 negative regulation of mitochondrial depolarization | IMP PMID:19767770 A novel pro-apoptotic function of RACK1: suppression of Src ... | KEEP AS NON CORE | Summary: IMP annotation to negative regulation of mitochondrial depolarization (GO:0051902) from PMID:19767770. RACK1-induced mitochondrial depolarisation depends partly on SRC inhibition (PMID:19767770). Reason: RACK1-induced mitochondrial depolarisation depends partly on SRC inhibition (PMID:19767770); indirect, non-core. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:0060576 intestinal epithelial cell development | IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege... | MARK AS OVER ANNOTATED | Summary: IDA annotation to intestinal epithelial cell development (GO:0060576) from PMID:25731159. PMID:25731159 describes a gp130-SRC-YAP module in inflammation-induced epithelial regeneration. Reason: PMID:25731159 describes a gp130-SRC-YAP module in inflammation-induced epithelial regeneration; that is tissue repair signalling rather than development of intestinal epithelial cells. Over-annotation. Supporting Evidence: PMID:25731159 Receptor binding by IL-6 and related cytokines engages gp130, which in addition to its well established effectors, the SHP-2-ERK, PI3K-Akt-mTORC1 and JAK-STAT3 modules, interacts with and activates Src and Yes. |
| GO:0060576 intestinal epithelial cell development | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA annotation to intestinal epithelial cell development (GO:0060576) from GO_REF:0000107. PMID:25731159 describes a gp130-SRC-YAP module in inflammation-induced epithelial regeneration. Reason: PMID:25731159 describes a gp130-SRC-YAP module in inflammation-induced epithelial regeneration; that is tissue repair signalling rather than development of intestinal epithelial cells. Over-annotation. Supporting Evidence: PMID:25731159 Receptor binding by IL-6 and related cytokines engages gp130, which in addition to its well established effectors, the SHP-2-ERK, PI3K-Akt-mTORC1 and JAK-STAT3 modules, interacts with and activates Src and Yes. |
| GO:0070062 extracellular exosome | HDA PMID:19056867 Large-scale proteomics and phosphoproteomics of urinary exos... | KEEP AS NON CORE | Summary: HDA annotation to extracellular exosome (GO:0070062) from PMID:19056867. SRC was detected in exosome proteomics. Reason: SRC was detected in exosome proteomics; this reflects packaging of a membrane-associated protein rather than a functional location. |
| GO:0070062 extracellular exosome | HDA PMID:20458337 MHC class II-associated proteins in B-cell exosomes and pote... | KEEP AS NON CORE | Summary: HDA annotation to extracellular exosome (GO:0070062) from PMID:20458337. SRC was detected in exosome proteomics. Reason: SRC was detected in exosome proteomics; this reflects packaging of a membrane-associated protein rather than a functional location. |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:25731159 A gp130-Src-YAP module links inflammation to epithelial rege... | KEEP AS NON CORE | Summary: IDA annotation to interleukin-6-mediated signaling pathway (GO:0070102) from PMID:25731159. gp130 engages and activates SRC in IL-6 signalling (PMID:25731159). Reason: gp130 engages and activates SRC in IL-6 signalling (PMID:25731159); context-specific pathway role. Supporting Evidence: PMID:25731159 Receptor binding by IL-6 and related cytokines engages gp130, which in addition to its well established effectors, the SHP-2-ERK, PI3K-Akt-mTORC1 and JAK-STAT3 modules, interacts with and activates Src and Yes. |
| GO:0070102 interleukin-6-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to interleukin-6-mediated signaling pathway (GO:0070102) from GO_REF:0000107. gp130 engages and activates SRC in IL-6 signalling (PMID:25731159). Reason: gp130 engages and activates SRC in IL-6 signalling (PMID:25731159); context-specific pathway role. Supporting Evidence: PMID:25731159 Receptor binding by IL-6 and related cytokines engages gp130, which in addition to its well established effectors, the SHP-2-ERK, PI3K-Akt-mTORC1 and JAK-STAT3 modules, interacts with and activates Src and Yes. |
| GO:0070161 anchoring junction | EXP PMID:22294297 Non-junctional human desmoglein 3 acts as an upstream regula... | ACCEPT | Summary: EXP annotation to anchoring junction (GO:0070161) from PMID:22294297. SRC is present at anchoring junctions (adherens junctions, focal adhesions). Reason: SRC is present at anchoring junctions (adherens junctions, focal adhesions). Supporting Evidence: PMID:22294297 Modulation of Dsg3 levels, either by Dsg3 silencing or over-expression, alters Src activity and its association with E-cadherin. |
| GO:0070161 anchoring junction | IEA GO_REF:0000044 | ACCEPT | Summary: IEA annotation to anchoring junction (GO:0070161) from GO_REF:0000044. SRC is present at anchoring junctions (adherens junctions, focal adhesions). Reason: SRC is present at anchoring junctions (adherens junctions, focal adhesions). Supporting Evidence: PMID:22294297 Modulation of Dsg3 levels, either by Dsg3 silencing or over-expression, alters Src activity and its association with E-cadherin. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to positive regulation of ERK1 and ERK2 cascade (GO:0070374) from GO_REF:0000107. SRC promotes ERK activation downstream of several receptors. Reason: SRC promotes ERK activation downstream of several receptors; electronic transfer, non-core. |
| GO:0070555 response to interleukin-1 | IMP PMID:19281832 Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are neces... | KEEP AS NON CORE | Summary: IMP annotation to response to interleukin-1 (GO:0070555) from PMID:19281832. SRC siRNA/inhibitor reduced IL-1beta-induced VCAM-1 expression (PMID:19281832). Reason: SRC siRNA/inhibitor reduced IL-1beta-induced VCAM-1 expression (PMID:19281832); context-specific signalling. |
| GO:0070700 BMP receptor binding | IPI PMID:26598555 VE-cadherin facilitates BMP-induced endothelial cell permeab... | KEEP AS NON CORE | Summary: IPI annotation to BMP receptor binding (GO:0070700) from PMID:26598555. SRC was found in BMP receptor/VE-cadherin complexes and mediates BMP6-induced VE-cadherin phosphorylation (PMID:26598555). Reason: SRC was found in BMP receptor/VE-cadherin complexes and mediates BMP6-induced VE-cadherin phosphorylation (PMID:26598555); a partner-class binding term, non-core. |
| GO:0070700 BMP receptor binding | IPI PMID:26598555 VE-cadherin facilitates BMP-induced endothelial cell permeab... | KEEP AS NON CORE | Summary: IPI annotation to BMP receptor binding (GO:0070700) from PMID:26598555. SRC was found in BMP receptor/VE-cadherin complexes and mediates BMP6-induced VE-cadherin phosphorylation (PMID:26598555). Reason: SRC was found in BMP receptor/VE-cadherin complexes and mediates BMP6-induced VE-cadherin phosphorylation (PMID:26598555); a partner-class binding term, non-core. |
| GO:0071253 connexin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to connexin binding (GO:0071253) from GO_REF:0000107. SRC binds and phosphorylates connexin-43 at gap junctions (UniProt). Reason: SRC binds and phosphorylates connexin-43 at gap junctions (UniProt); partner-class binding, non-core. |
| GO:0071375 cellular response to peptide hormone stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to cellular response to peptide hormone stimulus (GO:0071375) from GO_REF:0000107. Electronic/ISS transfer of responses to peptide hormones (e.g. Reason: Electronic/ISS transfer of responses to peptide hormones (e.g. angiotensin); context-specific. |
| GO:0071375 cellular response to peptide hormone stimulus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to cellular response to peptide hormone stimulus (GO:0071375) from GO_REF:0000024. Electronic/ISS transfer of responses to peptide hormones (e.g. Reason: Electronic/ISS transfer of responses to peptide hormones (e.g. angiotensin); context-specific. |
| GO:0071393 cellular response to progesterone stimulus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS annotation to cellular response to progesterone stimulus (GO:0071393) from GO_REF:0000024. SRC is activated in non-genomic progesterone signalling (ISS from rat). Reason: SRC is activated in non-genomic progesterone signalling (ISS from rat); context-specific. |
| GO:0086091 regulation of heart rate by cardiac conduction | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: IEA annotation to regulation of heart rate by cardiac conduction (GO:0086091) from GO_REF:0000107. Transferred from mouse/rat Src. Reason: Transferred from mouse/rat Src; cardiac conduction phenotypes arise from SRC regulation of channels and junctions and do not show SRC acting in heart-rate regulation per se. Over-annotation of an organism-level process. |
| GO:0086091 regulation of heart rate by cardiac conduction | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS annotation to regulation of heart rate by cardiac conduction (GO:0086091) from GO_REF:0000024. Transferred from mouse/rat Src. Reason: Transferred from mouse/rat Src; cardiac conduction phenotypes arise from SRC regulation of channels and junctions and do not show SRC acting in heart-rate regulation per se. Over-annotation of an organism-level process. |
| GO:0097110 scaffold protein binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA annotation to scaffold protein binding (GO:0097110) from GO_REF:0000107. SRC binds caveolin-1 and phosphorylates it on Tyr14 (PMID:25006397). Reason: SRC binds caveolin-1 and phosphorylates it on Tyr14 (PMID:25006397); partner-class binding, non-core. |
| GO:0097110 scaffold protein binding | IPI PMID:25006397 Nitrosation-dependent caveolin 1 phosphorylation, ubiquitina... | KEEP AS NON CORE | Summary: IPI annotation to scaffold protein binding (GO:0097110) from PMID:25006397. SRC binds caveolin-1 and phosphorylates it on Tyr14 (PMID:25006397). Reason: SRC binds caveolin-1 and phosphorylates it on Tyr14 (PMID:25006397); partner-class binding, non-core. |
| GO:1902564 negative regulation of neutrophil activation | IDA PMID:34234773 The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling... | KEEP AS NON CORE | Summary: IDA annotation to negative regulation of neutrophil activation (GO:1902564) from PMID:34234773. SRC phosphorylates the CLEC12A ITIM, initiating inhibitory signalling in neutrophils (PMID:34234773. Reason: SRC phosphorylates the CLEC12A ITIM, initiating inhibitory signalling in neutrophils (PMID:34234773; also a GO-CAM). A specific immune role, non-core. Supporting Evidence: PMID:34234773 CLEC12A cross-linking induced its translocation to flotillin-rich membrane domains where its ITIM was phosphorylated in a Src-dependent manner. |
| GO:1904263 positive regulation of TORC1 signaling | IDA PMID:35927303 Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 com... | KEEP AS NON CORE | Summary: IDA annotation to positive regulation of TORC1 signaling (GO:1904263) from PMID:35927303. SRC phosphorylates OTUB1 Tyr26, stabilising Raptor and supporting mTORC1 signalling (PMID:35927303. Reason: SRC phosphorylates OTUB1 Tyr26, stabilising Raptor and supporting mTORC1 signalling (PMID:35927303; also a GO-CAM). Context-specific. Supporting Evidence: PMID:35927303 Furthermore, non-receptor tyrosine kinases (Src and SRMS kinases) induced phosphorylation of OTUB1 at Y26, which stabilized Raptor. |
| GO:2000394 positive regulation of lamellipodium morphogenesis | IMP PMID:18054784 Autotaxin and lysophosphatidic acid stimulate intestinal cel... | KEEP AS NON CORE | Summary: IMP annotation to positive regulation of lamellipodium morphogenesis (GO:2000394) from PMID:18054784. LPA-induced lamellipodia formation requires c-src and villin phosphorylation (PMID:18054784). Reason: LPA-induced lamellipodia formation requires c-src and villin phosphorylation (PMID:18054784); context-specific. Supporting Evidence: PMID:18054784 The LPA-induced increase in cell migration required activation of c-src kinase and downstream tyrosine phosphorylation of villin by c-src kinase. |
| GO:2000641 regulation of early endosome to late endosome transport | IMP PMID:21724833 Identification of PTPN23 as a novel regulator of cell invasi... | KEEP AS NON CORE | Summary: IMP annotation to regulation of early endosome to late endosome transport (GO:2000641) from PMID:21724833. SRC inhibition reverses altered E-cadherin endosomal trafficking after PTPN23 loss (PMID:21724833). Reason: SRC inhibition reverses altered E-cadherin endosomal trafficking after PTPN23 loss (PMID:21724833); indirect, non-core. Supporting Evidence: PMID:21724833 Inhibition of SRC with the small molecular inhibitor SU6656 blocked the effects of PTPN23 depletion. |
| GO:2000811 negative regulation of anoikis | IMP PMID:22402981 Integrin/Fak/Src-mediated regulation of cell survival and an... | KEEP AS NON CORE | Summary: IMP annotation to negative regulation of anoikis (GO:2000811) from PMID:22402981. Integrin/FAK/SRC signalling suppresses anoikis in intestinal crypt cells (PMID:22402981). Reason: Integrin/FAK/SRC signalling suppresses anoikis in intestinal crypt cells (PMID:22402981); context-specific survival role. |
| GO:2001237 negative regulation of extrinsic apoptotic signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation to negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) from GO_REF:0000033. SRC phosphorylates caspase-8 (Tyr380), restraining extrinsic apoptosis. Reason: SRC phosphorylates caspase-8 (Tyr380), restraining extrinsic apoptosis; the IBA and IMP are plausible but describe a downstream survival role, non-core. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:2001237 negative regulation of extrinsic apoptotic signaling pathway | IMP PMID:19767770 A novel pro-apoptotic function of RACK1: suppression of Src ... | KEEP AS NON CORE | Summary: IMP annotation to negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) from PMID:19767770. SRC phosphorylates caspase-8 (Tyr380), restraining extrinsic apoptosis. Reason: SRC phosphorylates caspase-8 (Tyr380), restraining extrinsic apoptosis; the IBA and IMP are plausible but describe a downstream survival role, non-core. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:2001243 negative regulation of intrinsic apoptotic signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA annotation to negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) from GO_REF:0000033. SRC supports survival by restraining intrinsic (mitochondrial) apoptosis (PMID:19767770). Reason: SRC supports survival by restraining intrinsic (mitochondrial) apoptosis (PMID:19767770); non-core. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:2001243 negative regulation of intrinsic apoptotic signaling pathway | IMP PMID:19767770 A novel pro-apoptotic function of RACK1: suppression of Src ... | KEEP AS NON CORE | Summary: IMP annotation to negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) from PMID:19767770. SRC supports survival by restraining intrinsic (mitochondrial) apoptosis (PMID:19767770). Reason: SRC supports survival by restraining intrinsic (mitochondrial) apoptosis (PMID:19767770); non-core. Supporting Evidence: PMID:19767770 Collectively, our results show that RACK1, partly by inhibiting Src, promotes mitochondrial cell death and blocks Akt-mediated cell survival. |
| GO:2001286 regulation of caveolin-mediated endocytosis | IMP PMID:21724833 Identification of PTPN23 as a novel regulator of cell invasi... | KEEP AS NON CORE | Summary: IMP annotation to regulation of caveolin-mediated endocytosis (GO:2001286) from PMID:21724833. SRC activity underlies altered caveolin-mediated endocytosis after PTPN23 loss (PMID:21724833). Reason: SRC activity underlies altered caveolin-mediated endocytosis after PTPN23 loss (PMID:21724833); indirect, non-core. Supporting Evidence: PMID:21724833 Inhibition of SRC with the small molecular inhibitor SU6656 blocked the effects of PTPN23 depletion. |
| GO:0046777 protein autophosphorylation | IDA PMID:17491594 Regulation of c-Src by binding to the PDZ domain of AF-6. | NEW | Summary: SRC autophosphorylates its activation-loop tyrosine (Tyr419 in human, Tyr416 in chicken numbering), the step that fully activates the kinase once the SH2-tail and SH3-linker clamps are released. Reason: Participation test: SRC itself catalyses the step (it phosphorylates its own activation loop). Comparator check: LYN carries GO:0046777 (IDA) whereas LCK and FYN do not, so there is no convention against the term for Src-family kinases. Not an ancestor or descendant of any term SRC already carries. Activation-loop autophosphorylation is also predicted for choanoflagellate Src (MbSrc1 phosphorylates a Tyr419-site peptide; PMID:18390552). Supporting Evidence: PMID:17491594 Binding of c-Src to the AF-6 PDZ domain interferes with phosphorylation of c-Src at Tyr527 by the C-terminal kinase, and reduces c-Src autophosphorylation at Tyr416, resulting in a moderately activated c-Src kinase. PMID:18390552 MbSrc1 phosphorylated a peptide modeled on the Tyr-419 autophosphorylation sequence of mammalian Src, suggesting that MbSrc1 might also be capable of autophosphorylation. |
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Download this section (compressed HTML)Q: Was Csk phosphorylation of the Src tail already strongly inhibitory before animals? Monosiga ovata and M. brevicollis studies (PMID:16873552, PMID:18390552) found partial or weak inhibition, whereas a later yeast/in vitro study (PMID:28939764) reported Csk-mediated inhibition for Capsaspora and M. brevicollis proteins. Which assay conditions explain the difference? (The CSK review in this repository records the same dispute.)
Q: Which tyrosine-phosphorylated proteins does Src phosphorylate or bind in choanoflagellates and Capsaspora, and do any correspond to the animal focal-adhesion substrates (FAK, p130Cas, paxillin)? Capsaspora phosphoproteomics shows life-stage-specific tyrosine kinase phosphorylation (PMID:27746046) but not Src substrates specifically.
Q: Is the SRC C-terminal PDZ-binding motif conserved outside vertebrates, and does PDZ binding (AF-6, LNX1, MPP2, syntenin) represent a general SRC regulatory mechanism or a vertebrate addition?
Q: Should GO:0042169 SH2 domain binding (IPI, PMID:8070403, partner p130Cas) be retained, given that p130Cas lacks an SH2 domain and the cached abstract does not describe SRC binding an SH2 domain?
Experiment: Side-by-side kinetic and cellular comparison of human SRC, Monosiga and Capsaspora Src with their cognate Csk, using identical purified proteins and SYF-cell rescue, to settle whether tail phosphorylation was inhibitory before animals.
Experiment: Src knockout or knockdown in Capsaspora owczarzaki or Salpingoeca rosetta, followed by phosphotyrosine proteomics and imaging of adhesion structures (filopodia, substrate contacts, aggregates or rosettes), to test whether Src controls cell-substrate adhesion in unicellular holozoans.
Experiment: Swap experiments placing choanoflagellate Src SH2 or SH2-kinase linker into human SRC to map which residues couple SH2 engagement to catalytic regulation in animal SRC (PMID:18390552 found this coupling absent in MbSrc1).
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